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Biosafety

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https://www.readbyqxmd.com/read/29236469/synthetic-phenolic-antioxidants-cause-perturbation-in-steroidogenesis-in-vitro-and-in-vivo
#1
Xiaoxi Yang, Wenting Song, Na Liu, Zhendong Sun, Ruirui Liu, Qian S Liu, Qunfang Zhou, Guibin Jiang
Synthetic phenolic antioxidants (SPAs) are closely correlated with human life due to their extensive usages, and increasing concerns have been raised on their biosafety. The previous controversial findings caused continuous debates on their potential endocrine disrupting effects. In the present study, four commonly used SPAs, including butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tert-butyl hydroquinone (TBHQ) and 2,2'-methylenebis(6-tert-butyl-4-methylphenol) (AO2246), were investigated for their estrogenic effects, and the results from in vitro screening assays showed SPAs themselves had negligible estrogen receptor binding affinities...
December 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29234061/evaluation-of-promoting-effect-of-a-novel-cu-bearing-metal-stent-on-endothelialization-process-from-in-vitro-and-in-vivo-studies
#2
Shujing Jin, Xun Qi, Bin Zhang, Ziqing Sun, Bingchun Zhang, Hui Yang, Tongmin Wang, Bo Zheng, Xingang Wang, Qiuping Shi, Ming Chen, Ling Ren, Ke Yang, Hongshan Zhong
Drug eluting stents (DES) have been extensively applied nowadays and reduce the incidence of in-stent restenosis (ISR) greatly as compared with bare metal stents (BMS). However, the development of DES is hindered by the risk of late stent thrombosis (LST) due to delayed re-endothelialization, while endothelialization is an important process related to ISR and LST after implantation. 316L is a traditional stent material without bioactivity and have a high risk of ISR. Cu is recognized for angiogenesis stimulation in these years...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229433/establishment-of-integration-free-induced-pluripotent-stem-cells-from-human-recessive-dystrophic-epidermolysis-bullosa-keratinocytes
#3
Wakana Matsumura, Yasuyuki Fujita, Chihiro Nakayama, Satoru Shinkuma, Shotaro Suzuki, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu
BACKGROUND: Induced pluripotent stem cell (iPSC) technology enables patient-specific pluripotent stem cells to be derived from adult somatic cells without the use of an embryonic cell source. To date, recessive dystrophic epidermolysis bullosa (RDEB)-specific iPSCs have been generated from patients using integrating retroviral vectors. However, vector integration into the host genome can endanger the biosafety and differentiation propensities of iPSCs. Although various integration-free reprogramming systems have been reported, their utility in reprogramming somatic cells from patients remains largely undetermined...
December 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29224715/ebola-virus-disease-biological-and-diagnostic-evolution-from-2014-to-2017
#4
A Mérens, C Bigaillon, D Delaune
The Ebola virus disease outbreak observed in West Africa from March 2014 to June 2016 has led to many fundamental and applied research works. Knowledge of this virus has substantially increased. Treatment of many patients in epidemic countries and a few imported cases in developed countries led to developing new diagnostic methods and to adapt laboratory organization and biosafety precautions to perform conventional biological analyses. Clinical and biological monitoring of patients infected with Ebola virus disease helped to determine severity criteria and bad prognosis markers...
December 7, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29222105/the-emergency-medical-service-microbiome
#5
Andrew J Hudson, Graeme D Glaister, Hans-Joachim Wieden
Emergency medical services (EMS) personnel are an integral component of the healthcare framework and function to transport patients from various locations to and between care facilities. In addition to physical injury, EMS personnel are expected to be at high risk to acquire and transmit healthcare associated infections (HAIs) in the workplace. However, currently little is known about EMS biosafety risk factors and the epidemiological contribution of EMS to pathogen transmission within and outside of the healthcare sector...
December 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29220758/interaction-of-a-digestive-protease-candida-rugosa-lipase-with-three-surfactants-investigated-by-spectroscopy-molecular-docking-and-enzyme-activity-assay
#6
Rui Zhang, Yang Liu, Xinran Huang, Mengchen Xu, Rutao Liu, Wansong Zong
The extensive use of surfactants in food, laundry products and agriculture has caused concern about their biosafety. However, few studies have been done on their potential effect on the lipase which has always been used with surfactants in food and laundry industry. Herein, we investigated the interaction of three surfactants (sodium dodecyl sulfate (SDS), sodium dodecyl benzene sulfonate (SDBS), sodium lauryl sulfonate (SLS)) with Candida rugosa lipase (CRL), which is a popular biocatalyst used regularly with surfactants...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29218769/current-status-on-the-development-of-pseudoviruses-for-enveloped-viruses
#7
REVIEW
Qianqian Li, Qiang Liu, Weijin Huang, Xuguang Li, Youchun Wang
Emerging and reemerging infectious diseases have a strong negative impact on public health. However, because many of these pathogens must be handled in biosafety level, 3 or 4 containment laboratories, research and development of antivirals or vaccines against these diseases are often impeded. Alternative approaches to address this issue have been vigorously pursued, particularly the use of pseudoviruses in place of wild-type viruses. As pseudoviruses have been deprived of certain gene sequences of the virulent virus, they can be handled in biosafety level 2 laboratories...
December 7, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29217339/standardization-chemical-profiling-in%C3%A2-vitro-cytotoxic-effects-in%C3%A2-vivo-anti-carcinogenic-potential-and-biosafety-profile-of-indian-propolis
#8
Harshad Kapare, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, Kakasaheb Mahadik
BACKGROUND: Propolis from apiculture is known for wide range of medicinal properties owing to its vast chemical constituents including polyphenols, flavonoids and anticancer agent Caffeic acid phenethyl ester (CAPE). OBJECTIVES: The objective of the study was to extract and standardize Indian propolis (IP) with respect to selected markers by newly developed High performance liquid chromatography (HPLC) method, to evaluate in vitro and in vivo anticancer activity and biosafety of Indian propolis...
December 4, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29214127/in-situ-synthesis-of-silver-nanoparticles-on-the-surface-of-pdms-with-high-antibacterial-activity-and-biosafety-toward-an-implantable-medical-device
#9
Joong Hyun Kim, HyeungWoo Park, Soo Won Seo
We developed a straightforward method to fabricate antibacterial silicon films via the in situ synthesis of silver nanoparticles (AgNPs) on a polydimethylsiloxane (PDMS) film. To grow AgNPs attached on the film, AgNP seeds were synthesized through the reduction of silver ions electrostatically bound to hydroxyl groups formed on the surface of the film after treatment with air plasma. In the growth reaction, silver ions were reduced on the seeds of AgNPs by sodium citrate in a solution of AgNO3, which allowed for the formation of AgNPs with sizes of up to ~ 500 nm, which The formed AgNPs on the films were characterized using UV-vis spectrophotometer, scattering electron microscope and induced coupled mass spectrometer...
2017: Nano Convergence
https://www.readbyqxmd.com/read/29212933/characterization-of-an-influenza-virus-pseudotyped-with-ebolavirus-glycoprotein
#10
Julie Xiao, Pramila Rijal, Lisa Schimanski, Arun Kumar Tharkeshwar, Edward Wright, Wim Annaert, Alain Townsend
We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green fluorescence protein as a reporter that replaces the influenza haemagglutinin. MDCK-SIAT1 cells were transduced to express Ebolavirus glycoprotein as a stable transmembrane protein for E-S-FLU production. Infection of cells by E-S-FLU was dependent on Niemann-Pick C1 protein, which is the well-characterized receptor for Ebola virus entry at the late endosome/lysosome membrane...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29211068/spontaneous-protein-desorption-from-self-assembled-monolayer-sam-coated-gold-nanoparticles
#11
Ranran Tian, Mengbo Luo, Jingyuan Li
When nanoparticles enter blood or other biological fluids, they tend to contact with a variety of proteins which may hamper their application and even bring adverse impacts. Such nonspecific protein binding is usually weak and proteins reach dynamic equilibrium between adsorption and desorption. Studies on the spontaneous desorption of weakly bound proteins should not only be helpful to enrich our understanding about such nonspecific interactions but also shed light on the strategy to avoid nonspecific binding of proteins...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29210682/advanced-treatment-of-landfill-leachate-membrane-concentrates-performance-comparison-biosafety-and-toxic-residue-analysis
#12
Mianwei Hong, Gang Lu, Changcheng Hou, Shaohua She, Lingfei Zhu
With the improvement of people's consciousness about health, more attention has been paid to the biosafety of effluent reaching conventional discharge standard. In this contribution, removal efficiency of chemical oxygen demand (COD), acute toxicity, genotoxicity and estrogenicity in landfill leachate membrane concentrates (MCs) among UV-Fenton, Fenton and activated carbon adsorption process were compared. Daphnia magna acute toxicity assay, comet assay, cytokinesis-block micronucleus and E-screen assay were performed to assess whether the effluent reaching the main parameters of Chinese Discharge Standard (GB 16889-2008) still had toxic residues...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29207531/microbial-and-plant-assisted-bioremediation-of-heavy-metal-polluted-environments-a-review
#13
REVIEW
Omena Bernard Ojuederie, Olubukola Oluranti Babalola
Environmental pollution from hazardous waste materials, organic pollutants and heavy metals, has adversely affected the natural ecosystem to the detriment of man. These pollutants arise from anthropogenic sources as well as natural disasters such as hurricanes and volcanic eruptions. Toxic metals could accumulate in agricultural soils and get into the food chain, thereby becoming a major threat to food security. Conventional and physical methods are expensive and not effective in areas with low metal toxicity...
December 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29199043/evaluating-interest-in-an-influenza-a-h5n1-vaccine-among-laboratory-workers-who-work-with-highly-pathogenic-avian-influenza-viruses-in-the-united-states
#14
Kate E Russell, J S Bresee, J M Katz, S J Olsen
BACKGROUND: Highly pathogenic avian influenza A (HPAI) viruses found in poultry and wild birds occasionally infect humans and can cause serious disease. In 2014, the Advisory Committee on Immunization Practices (ACIP) reviewed data from one licensed ASO3-adjuvanted influenza A(H5N1) vaccine for consideration of use during inter-pandemic periods among persons with occupational exposure. To guide vaccine policy decisions, we conducted a survey of laboratory workers to assess demand for HPAI vaccination...
November 30, 2017: Vaccine
https://www.readbyqxmd.com/read/29195216/photo-induced-toxicity-of-tungsten-oxide-photochromic-nanoparticles
#15
A L Popov, N M Zholobak, O I Balko, O B Balko, A B Shcherbakov, N R Popova, O S Ivanova, A E Baranchikov, V K Ivanov
We synthesised a new type of photochromic tungsten oxide nanoparticles, analysed their photocatalytic activity and carried out a thorough analysis of their effect on prokaryotic and eukaryotic organisms. Ultrasmall hydrated tungsten oxide nanoparticles were prepared by means of hydrothermal treatment of tungstic acid in the presence of polyvinylpyrrolidone as a template, stabiliser and growth regulator. Tungstic acid was synthesised through an ion-exchange method using sodium tungstate solution and a strongly acidic cation exchange resin...
November 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29194780/black-phosphorus-nanosheets-as-a-neuroprotective-nanomedicine-for-neurodegenerative-disorder-therapy
#16
Wansong Chen, Jiang Ouyang, Xinyao Yi, Yan Xu, Chengcheng Niu, Weiyu Zhang, Liqiang Wang, Jianping Sheng, Liu Deng, You-Nian Liu, Shaojun Guo
Transition-metal dyshomeostasis is recognized as a critical pathogenic factor at the onset and progression of neurodegenerative disorder (ND). Excess transition-metal ions such as Cu2+ can catalyze the generation of cytotoxic reactive oxygen species and thereafter induce neuronal cell apoptosis. Exploring new chelating agents, which are not only capable of capturing excess redox-active metal, but can also cross the blood-brain barrier (BBB), are highly desired for ND therapy. Herein, it is demonstrated that 2D black phosphorus (BP) nanosheets can capture Cu2+ efficiently and selectively to protect neuronal cells from Cu2+ -induced neurotoxicity...
November 30, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29193983/characterization-of-departures-from-regulatory-requirements-identified-during-inspections-conducted-by-the-us-federal-select-agent-program-2014-15
#17
Adam Bjork, Daniel M Sosin
We studied departures from regulatory requirements identified on US Federal Select Agent Program (FSAP) inspections to increase transparency regarding biosafety and security risk at FSAP-regulated entities and identify areas for programmatic improvement. Regulatory departures from inspections led by Centers for Disease Control and Prevention inspectors during 2014-15 were grouped into "biosafety," "security," and "other" observation categories and assigned a risk level and score reflecting perceived severity...
December 1, 2017: Health Security
https://www.readbyqxmd.com/read/29193848/mesoporous-silica-and-organosilica-nanoparticles-physical-chemistry-biosafety-delivery-strategies-and-biomedical-applications
#18
REVIEW
Jonas G Croissant, Yevhen Fatieiev, Abdulaziz Almalik, Niveen M Khashab
Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles...
November 30, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29190713/operational-evaluation-of-rapid-diagnostic-testing-for-ebola-virus-disease-in-guinean-laboratories
#19
Amanda VanSteelandt, Josephine Aho, Kristyn Franklin, Jacques Likofata, Jean Baptiste Kamgang, Sakoba Keita, Lamine Koivogui, N'Faly Magassouba, Lise D Martel, Anicet George Dahourou
BACKGROUND: Rapid Diagnostic Tests (RDTs) for Ebola Virus Disease (EVD) at the point of care have the potential to increase access and acceptability of EVD testing and the speed of patient isolation and secure burials for suspect cases. A pilot program for EVD RDTs in high risk areas of Guinea was introduced in October 2015. This paper presents concordance data between EVD RDTs and PCR testing in the field as well as an assessment of the acceptability, feasibility, and quality assurance of the RDT program...
2017: PloS One
https://www.readbyqxmd.com/read/29188176/nano-sized-indocyanine-green-j-aggregate-as-a-one-component-theranostic-agent
#20
Renfa Liu, Jie Tang, Yunxue Xu, Yiming Zhou, Zhifei Dai
The development of biocompatiable efficient photothermal coupling agent (PCA) for image-guided photothermal therapy of cancer has gained increasing interests in recent years. Although various PCAs have been developed, the clinical translations of these materials have been largely hindered by the potential biosafety issues and challenges of scaling-up manufactures. In this research, we proposed nano-sized indocyanine green (ICG) J-aggregate (IJA) as a promising PCA which is fabricated by a very facile method using clinical-approved ICG as the only excipient...
2017: Nanotheranostics
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