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https://www.readbyqxmd.com/read/28222526/the-impact-of-alzheimer-s-disease-on-the-resting-state-functional-connectivity-of-brain-regions-modulating-pain-a-cross-sectional-study
#1
Todd B Monroe, Paul A Beach, Stephen P Bruehl, Mary S Dietrich, Baxter P Rogers, John C Gore, Sebastian W Atalla, Ronald L Cowan
BACKGROUND: It is currently unknown why people with Alzheimer's disease (AD) receive less pain medication and report pain less frequently. OBJECTIVE: The purpose of this study was to determine the impact of AD on thermal psychophysics and resting-state functional connectivity (RSFC) among sensory, affective, descending modulatory, and default mode structures. METHODS: Controls (n = 23, 13 = female) and age-matched people with AD (n = 23, 13 = females) underwent psychophysical testing to rate perceptions of warmth, mild, and moderate pain and then completed resting-state fMRI...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28220377/altered-functional-connectivity-architecture-of-the-brain-in-medication-overuse-headache-using-resting-state-fmri
#2
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Zhao Dong, Lin Ma, Shengyuan Yu
BACKGROUND: Functional connectivity density (FCD) could identify the abnormal intrinsic and spontaneous activity over the whole brain, and a seed-based resting-state functional connectivity (RSFC) could further reveal the altered functional network with the identified brain regions. This may be an effective assessment strategy for headache research. This study is to investigate the RSFC architecture changes of the brain in the patients with medication overuse headache (MOH) using FCD and RSFC methods...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28220069/effects-of-selective-serotonin-reuptake-inhibitors-on-interregional-relation-of-serotonin-transporter-availability-in-major-depression
#3
Gregory M James, Pia Baldinger-Melich, Cecile Philippe, Georg S Kranz, Thomas Vanicek, Andreas Hahn, Gregor Gryglewski, Marius Hienert, Marie Spies, Tatjana Traub-Weidinger, Markus Mitterhauser, Wolfgang Wadsak, Marcus Hacker, Siegfried Kasper, Rupert Lanzenberger
Selective serotonin reuptake inhibitors (SSRIs) modulate serotonergic neurotransmission by blocking reuptake of serotonin from the extracellular space. Up to now, it remains unclear how SSRIs achieve their antidepressant effect. However, task-based and resting state functional magnetic resonance imaging studies, have demonstrated connectivity changes between brain regions. Here, we use positron emission tomography (PET) to quantify SSRI's main target, the serotonin transporter (SERT), and assess treatment-induced molecular changes in the interregional relation of SERT binding potential (BPND)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28219620/brain-structural-correlates-of-executive-and-social-cognition-profiles-in-behavioral-variant-frontotemporal-dementia-and-elderly-bipolar-disorder
#4
Sandra Baez, Clara Pinasco, María Roca, Jesica Ferrari, Blas Couto, Indira García-Cordero, Agustín Ibañez, Francy Cruz, Pablo Reyes, Diana Matallana, Facundo Manes, Marcelo Cetcovich, Teresa Torralva
An early stage of behavioral variant frontotemporal dementia (bvFTD) often displays a mix of behavioral disturbances and personality changes hindering a differential diagnosis from elderly bipolar disorder (BD), making this process a big challenge. However, no studies have compared these pathologies from neuropsychological and neuroanatomical perspectives. The aim of the present study was to compare the executive functions (EF) and social cognition profiles as well as the structural neuroimaging of bvFTD and elderly patients with BD...
February 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28211813/classification-of-depression-cognitive-disorders-and-co-morbid-depression-and-cognitive-disorders-with-perfusion-spect-neuroimaging
#5
Daniel G Amen, Pavitra Krishnamani, Somayeh Meysami, Andrew Newberg, Cyrus A Raji
BACKGROUND: Depression and cognitive disorders (CDs) are two common co-morbid afflictions that commonly present with overlapping symptoms. OBJECTIVE: To evaluate if perfusion neuroimaging with brain SPECT can distinguish persons with depression from those with CDs or both conditions. METHODS: Inclusion criteria were DSM-IV defined depression or CDs (Alzheimer's disease, vascular dementia, dementia not otherwise specified, and amnestic disorders not otherwise specified) including persons with both (total n = 4,541; 847 CDs, 3,269 depression, 425 with both)...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28210930/emotion-specific-nocebo-effects-an-fmri-study
#6
Anne Schienle, Carina Höfler, Sonja Übel, Albert Wabnegger
The neurobiological mechanisms of nocebos are still poorly understood. Thirty-eight women participated in a 'smell study' using functional magnetic resonance imaging. They were presented with an odorless stimulus (distilled water) together with the verbal suggestion that this fluid has an aversive odor which enhances disgust feelings. The nocebo was presented while the participants viewed disgusting, fear-inducing, and neutral images. Participants' affective and neuronal responses during nocebo administration were compared with those in a control condition without nocebo...
February 16, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28209520/deconstructing-empathy-neuroanatomical-dissociations-between-affect-sharing-and-prosocial-motivation-using-a-patient-lesion-model
#7
Suzanne M Shdo, Kamalini G Ranasinghe, Kelly A Gola, Clinton J Mielke, Paul V Sukhanov, Bruce L Miller, Katherine P Rankin
Affect sharing and prosocial motivation are integral parts of empathy that are conceptually and mechanistically distinct. We used a neurodegenerative disease (NDG) lesion model to more directly examine the neural correlates of these two aspects of real-world empathic responding. The study enrolled 275 participants, including 44 healthy older controls and 231 patients diagnosed with one of five neurodegenerative diseases (75 Alzheimer's disease, 58 behavioral variant frontotemporal dementia (bvFTD), 42 semantic variant primary progressive aphasia (svPPA), 28 progressive supranuclear palsy, and 28 non-fluent variant (nfvPPA)...
February 13, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28208068/altered-olfactory-processing-and-increased-insula-activity-in-patients-with-obsessive-compulsive-disorder-an-fmri-study
#8
Heather A Berlin, Emily R Stern, Johnny Ng, Sam Zhang, David Rosenthal, Rachel Turetzky, Cheuk Tang, Wayne Goodman
Obsessive-compulsive disorder (OCD) patients show increased insula activation to disgust-inducing images compared to healthy controls (HC). We explored whether this disgust reactivity was also present in the olfactory domain by conducting the first fMRI study of olfaction in OCD. Neural activation in response to pleasant and unpleasant odors (vs. unscented air) was investigated in 15 OCD and 15 HC participants using fMRI. OCD participants (vs. HC) had increased left anterior insula activation to unpleasant odors (vs...
February 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28207751/flavor-pleasantness-processing-in-the-ventral-emotion-network
#9
Jelle R Dalenberg, Liselore Weitkamp, Remco J Renken, Luca Nanetti, Gert J Ter Horst
The ventral emotion network-encompassing the amygdala, insula, ventral striatum, and ventral regions of the prefrontal cortex-has been associated with the identification of emotional significance of perceived external stimuli and the production of affective states. Functional magnetic resonance imaging (fMRI) studies investigating chemosensory stimuli have associated parts of this network with pleasantness coding. In the current study, we independently analyzed two datasets in which we measured brain responses to flavor stimuli in young adult men...
2017: PloS One
https://www.readbyqxmd.com/read/28205497/critical-motor-involvement-in-prediction-of-human-and-non-biological-motion-trajectories
#10
Matthieu M de Wit, Laurel J Buxbaum
OBJECTIVES: Adaptive interaction with the environment requires the ability to predict both human and non-biological motion trajectories. Prior accounts of the neurocognitive basis for prediction of these two motion classes may generally be divided into those that posit that non-biological motion trajectories are predicted using the same motor planning and/or simulation mechanisms used for human actions, and those that posit distinct mechanisms for each. Using brain lesion patients and healthy controls, this study examined critical neural substrates and behavioral correlates of human and non-biological motion prediction...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28205277/preliminary-evaluation-of-altered-brain-microstructure-in-the-emotion-cognition-region-in-children-with-haemophilia-a-a-diffusional-kurtosis-imaging-study
#11
D Hu, H Kang, Y Lv, N Zhang, L Tang, J Zhang, K Shi, R Wu, Y Peng
AIM: Using diffusional kurtosis imaging (DKI) to assess the impact of emotional disorders on microstructural changes of the brain in children with haemophilia A. MATERIALS AND METHODS: Diffusional kurtosis imaging was acquired from haemophilia A (n = 22) and controls (n = 22) using a 3T scanner. A regression analysis of frontal, cingulate, hippocampus, insula and amygdala regions of interest (ROIs) was conducted. Clinical data and results of psychological tests were collected...
February 15, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28202427/the-insula-lobe-and-sudden-unexpected-death-in-epilepsy-a-hypothesis
#12
Jia Li, Qianwen Ming, Weihong Lin
Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in patients with refractory epilepsy, particularly those with chronic epilepsy. The physiopathological mechanisms underlying SUDEP have not been elucidated. Autonomic dysregulation of cardiac or respiratory function is thought to underlie SUDEP. Here, we present a summary of available evidence on the involvement of the insular lobe in the regulation of cardiorespiratory function. Ictal discharge that originates in the cortex can, primarily or secondarily, involve the insula lobe through epileptogenic signal networks, leading to cardiorespiratory dysfunction, central apnoea, arrhythmias, and sudden death in patients with epilepsy...
February 15, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28202336/functional-connectivity-in-resting-state-as-a-phonemic-fluency-ability-measure
#13
Anna Miró-Padilla, Elisenda Bueichekú, Noelia Ventura-Campos, María-Ángeles Palomar-García, César Ávila
There is some evidence that functional connectivity (FC) measures obtained at rest may reflect individual differences in cognitive capabilities. We tested this possibility by using the FAS test as a measure of phonemic fluency. Seed regions of the main brain areas involved in this task were extracted from meta-analysis results (Wagner et al., 2014) and used for pairwise resting-state FC analysis. Ninety-three undergraduates completed the FAS test outside the scanner. A correlation analysis was conducted between the F-A-S scores (behavioral testing) and the pairwise FC pattern of verbal fluency regions of interest...
February 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28197859/imaging-the-up-s-and-down-s-of-emotion-regulation-in-lifetime-depression
#14
Sina Radke, Felix Hoffstaedter, Leonie Löffler, Lydia Kogler, Frank Schneider, Jens Blechert, Birgit Derntl
Reappraisal is a particularly effective strategy for influencing emotional experiences, specifically for reducing the impact of negative stimuli. Although depression has repeatedly been linked to dysfunctional behavioral and neural emotion regulation, prefrontal and amygdala engagement seems to vary with clinical characteristics and the specific regulation strategy used. Whereas previous neuroimaging research has focused on down-regulating reactions to emotionally evocative scenes, the current study compared up- and down-regulation in response to angry facial expressions in patients with depression and healthy individuals...
February 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28197096/resting-state-brain-anomalies-in-type-2-diabetes-a-meta-analysis
#15
REVIEW
Wenqing Xia, Yu-Chen Chen, Jianhua Ma
Resting-state functional magnetic resonance imaging (fMRI) studies have revealed abnormal neural activity in patients with type 2 diabetes mellitus (T2DM). Nonetheless, these findings are heterogeneous and have not been quantitatively reviewed. Thus, we aimed to conduct a meta-analysis that identified consistent results of existing resting-state fMRI studies to determine concordant resting-state neural brain activity alterations in T2DM patients. A systematic search was conducted for resting-state fMRI studies comparing T2DM patients with healthy controls...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28195139/altered-insula-connectivity-under-mdma
#16
Ishan C Walpola, Timothy Nest, Leor Roseman, David Erritzoe, Amanda Feilding, David J Nutt, Robin L Carhart-Harris
Recent work with noninvasive human brain imaging has started to investigate the effects of 3, 4-methylenedioxymethamphetamine (MDMA) on large-scale patterns of brain activity. MDMA, a potent monoamine-releaser with particularly pronounced serotonin- releasing properties, has unique subjective effects that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic feelings. However, the neurobiological basis for these effects is not properly understood, and the present analysis sought to address this knowledge gap...
February 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28193583/nicotinic-modulation-of-salience-network-connectivity-and-centrality-in-schizophrenia
#17
Jason Smucny, Korey P Wylie, Eugene Kronberg, Kristina T Legget, Jason R Tregellas
Although functional abnormalities of the salience network are associated with schizophrenia, the acute effects of nicotine on its function and network dynamics during the resting state in patients are poorly understood. In this study, the effects of a 7 mg nicotine patch (vs. placebo) on salience network connectivity were examined in 17 patients with schizophrenia and 19 healthy subjects. We hypothesized abnormal connectivity between the salience network and other major networks (e.g. executive network) in patients under placebo administration and amelioration of this difference after nicotine...
February 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28192648/mapping-of-brain-activations-to-rectal-balloon-distension-stimuli-in-male-patients-with-irritable-bowel-syndrome-using-functional-magnetic-resonance-imaging
#18
Anupam Guleria, Arun Karyampudi, Rajan Singh, Chunni L Khetrapal, Abhai Verma, Uday C Ghoshal, Dinesh Kumar
Background/Aims: Irritable bowel syndrome (IBS) is associated with exaggerated cerebral response including emotional processing following visceral stimulation; though data on this issue is available in female IBS patients, it is scanty among male. Hence, we aimed to study brain response of male IBS patients following rectal balloon distension as compared to healthy controls using functional magnetic resonance imaging (fMRI). Data between diarrhea and constipation predominant IBS (IBS-D and IBS-C) were also compared...
February 14, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28188914/connectivity-based-parcellation-reveals-distinct-cortico-striatal-connectivity-fingerprints-in-autism-spectrum-disorder
#19
Joshua H Balsters, Dante Mantini, Nicole Wenderoth
Autism Spectrum Disorder (ASD) has been associated with abnormal synaptic development causing a breakdown in functional connectivity. However, when measured at the macro scale using resting state fMRI, these alterations are subtle and often difficult to detect due to the large heterogeneity of the pathology. Recently, we outlined a novel approach for generating robust biomarkers of resting state functional magnetic resonance imaging (RS-fMRI) using connectivity based parcellation of gross morphological structures to improve single-subject reproducibility and generate more robust connectivity fingerprints...
February 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28188881/abnormal-regional-activity-and-functional-connectivity-in-resting-state-brain-networks-associated-with-etiology-confirmed-unilateral-pulsatile-tinnitus-in-the-early-stage-of-disease
#20
Han Lv, Pengfei Zhao, Zhaohui Liu, Rui Li, Ling Zhang, Peng Wang, Fei Yan, Liheng Liu, Guopeng Wang, Rong Zeng, Ting Li, Cheng Dong, Shusheng Gong, Zhenchang Wang
Abnormal neural activities can be revealed by resting-state functional magnetic resonance imaging (rs-fMRI) using analyses of the regional activity and functional connectivity (FC) of the networks in the brain. This study was designed to demonstrate the functional network alterations in the patients with pulsatile tinnitus (PT). In this study, we recruited 45 patients with unilateral PT in the early stage of disease (less than 48 months of disease duration) and 45 normal controls. We used regional homogeneity (ReHo) and seed-based FC computational methods to reveal resting-state brain activity features associated with pulsatile tinnitus...
February 7, 2017: Hearing Research
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