Janelle Liu, Jessica B Girault, Tomoyuki Nishino, Mark D Shen, Sun Hyung Kim, Catherine A Burrows, Jed T Elison, Natasha Marrus, Jason J Wolff, Kelly N Botteron, Annette M Estes, Stephen R Dager, Heather C Hazlett, Robert C McKinstry, Robert T Schultz, Abraham Z Snyder, Martin Styner, Lonnie Zwaigenbaum, John R Pruett, Joseph Piven, Wei Gao
The amygdala undergoes a period of overgrowth in the first year of life, resulting in enlarged volume by 12 months in infants later diagnosed with ASD. The overgrowth of the amygdala may have functional consequences during infancy. We investigated whether amygdala connectivity differs in 12-month-olds at high likelihood (HL) for ASD (defined by having an older sibling with autism), compared to those at low likelihood (LL). We examined seed-based connectivity of left and right amygdalae, hypothesizing that the HL and LL groups would differ in amygdala connectivity, especially with the visual cortex, based on our prior reports demonstrating that components of visual circuitry develop atypically and are linked to genetic liability for autism...
May 2, 2024: Cerebral Cortex