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https://www.readbyqxmd.com/read/28749471/pre-synaptic-trkb-in-basolateral-amygdala-neurons-mediates-bdnf-signaling-transmission-in-memory-extinction
#1
Yuan Li, Dongdong Wang, Yang Li, Hongxia Chu, Lining Zhang, Ming Hou, Xingyu Jiang, Zheyu Chen, Bo Su, Tao Sun
Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, TrkB, play an essential role in memory extinction. Our previous work has shown that JIP3 (JNK interacted protein 3) mediates anterograde axonal transport of TrkB through the direct binding of its coiled-coil domain 1 (CC1) with TrkB. Here, we constructed a fluorescent CC1 and enhanced green fluorescent protein (EGFP) fused protein, CC1-EGFP, and found that CC1-EGFP could specifically interrupt TrkB anterograde axonal transport and its localization at the pre-synaptic site...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749455/primary-biliary-cholangitis-alters-functional-connections-of-the-brain-s-deep-gray-matter
#2
Victoria A L Mosher, Mark G Swain, Jack X Q Pang, Gilaad G Kaplan, Keith A Sharkey, Glenda M MacQueen, Bradley G Goodyear
OBJECTIVES: Fatigue, itch, depressed mood, and cognitive impairment significantly impact the quality of life of many patients with primary biliary cholangitis (PBC). Previous neuroimaging studies of non-hepatic diseases suggest that these symptoms are often associated with dysfunction of deep gray matter brain regions. We used resting-state functional magnetic resonance imaging (rsfMRI) to determine whether PBC patients exhibit altered functional connections of deep gray matter. METHODS: Twenty female non-cirrhotic PBC patients and 21 age/gender-matched controls underwent rsfMRI...
July 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28747683/failure-in-cognitive-suppression-of-negative-affect-in-adolescents-with-generalized-anxiety-disorder
#3
Dazhi Yin, Wenjing Liu, Kristina Zeljic, Qian Lv, Zhiwei Wang, Meina You, Weiwei Men, Mingxia Fan, Wenhong Cheng, Zheng Wang
Hyperactivity of limbic (e.g., amygdalar) responses to negative stimuli has been implicated in the pathophysiology of generalized anxiety disorder (GAD). Evidence has also suggested that even a simple cognitive task involving emotionally salient stimuli can modulate limbic and prefrontal neural activation. However, whether neural modulation of emotional stimulus processing in a cognitive task is defective in adolescents with GAD has not yet been investigated. In this study, 20 adolescents with GAD and 14 comparable healthy controls underwent event-related functional magnetic resonance imaging (fMRI) coupled with an emotional valence evaluation task...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747086/menthol-enhances-nicotine-induced-locomotor-sensitization-and-in-vivo-functional-connectivity-in-adolescence
#4
Matthew F Thompson, Guillaume L Poirier, Martha I Dávila-García, Wei Huang, Kelly Tam, Maxwell Robidoux, Michelle L Dubuke, Scott A Shaffer, Luis Colon-Perez, Marcelo Febo, Joseph R DiFranza, Jean A King
Mentholated cigarettes capture a quarter of the US market, and are disproportionately smoked by adolescents. Menthol allosterically modulates nicotinic acetylcholine receptor function, but its effects on the brain and nicotine addiction are unclear. To determine if menthol is psychoactive, we assessed locomotor sensitization and brain functional connectivity. Adolescent male Sprague Dawley rats were administered nicotine (0.4 mg/kg) daily with or without menthol (0.05 mg/kg or 5.38 mg/kg) for nine days. Following each injection, distance traveled in an open field was recorded...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28746840/quantitative-assessments-of-extracellular-eeg-to-classify-specific-features-of-main-phases-of-seizure-acquisition-based-on-kindling-model-in-rat
#5
Mostafa Jalilifar, Ali Yadollahpour, Ahmad Ali Moazedi, Zohreh Ghotbeddin
OBJECTIVE: Quantitative assessments of extracellular EEG to identify specific features of three main phases of seizure acquisition based on kindling model in Rat. METHODS: Male rats were divided into 2 groups including kindled (n=10) and sham (n=7) and respectively underwent an amygdala rapid kindling and placebo kindling. EEG signals in stages 1-2 (initial seizure stages (ISSs)), 3 (localized seizure stage (LSS)), and 4-5 generalized seizure stages (GSSs) were divided into 5 bands: delta (0-4Hz), theta (4-8Hz), alpha (8-12Hz), beta (12-28Hz), and gamma (28-40Hz)...
July 23, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28745263/externalizing-behavior-severity-in-youths-with-callous-unemotional-traits-corresponds-to-patterns-of-amygdala-activity-and-connectivity-during-judgments-of-causing-fear-corrigendum
#6
Elise M Cardinale, Andrew L Breeden, Emily L Robertson, Leah M Lozier, John W Vanmeter, Abigail A Marsh
No abstract text is available yet for this article.
July 26, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28744939/neural-substrates-of-context-and-person-dependent-altruistic-punishment
#7
Lili Wang, Xiaping Lu, Ruolei Gu, Ruida Zhu, Rui Xu, Lucas S Broster, Chunliang Feng
Human altruistic behaviors are heterogeneous across both contexts and people, whereas the neural signatures underlying the heterogeneity remain to be elucidated. To address this issue, we examined the neural signatures underlying the context- and person-dependent altruistic punishment, conjoining event-related fMRI with both task-based and resting-state functional connectivity (RSFC). Acting as an impartial third party, participants decided how to punish norm violators either alone or in the presence of putative others...
July 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28744913/aggression-related-brain-function-assessed-with-the-point-subtraction-aggression-paradigm-in-fmri
#8
Anine P Skibsted, Sofi da Cunha-Bang, Justin M Carré, Adam E Hansen, Vincent Beliveau, Gitte M Knudsen, Patrick M Fisher
The Point Subtraction Aggression Paradigm (PSAP) measures aggressive behavior in response to provocations. The aim of the study was to implement the PSAP in a functional neuroimaging environment (fMRI) and evaluate aggression-related brain reactivity including response to provocations and associations with aggression within the paradigm. Twenty healthy participants completed two 12-min PSAP sessions within the scanner. We evaluated brain responses to aggressive behavior (removing points from an opponent), provocations (point subtractions by the opponent), and winning points...
July 25, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28743727/basolateral-amygdala-to-orbitofrontal-cortex-projections-enable-cue-triggered-reward-expectations
#9
Nina T Lichtenberg, Zachary T Pennington, Sandra M Holley, Venuz Y Greenfield, Carlos Cepeda, Michael S Levine, Kate M Wassum
To make an appropriate decision one must anticipate potential future rewarding events, even when they are not readily observable. These expectations are generated by using observable information (e.g., stimuli or available actions) to retrieve often quite detailed memories of available rewards. The basolateral amygdala (BLA) and orbitofrontal cortex (OFC) are two reciprocally-connected key nodes in the circuitry supporting such outcome-guided behaviors. But there is much unknown about the contribution of this circuit to decision making, and almost nothing known about the whether any contribution is via direct, monosynaptic projections, or the direction of information transfer...
July 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28742077/mediation-by-anxiety-of-the-relationship-between-amygdala-activity-during-emotion-processing-and-poor-quality-of-life-in-young-adults
#10
T Greenberg, M A Bertocci, H W Chase, R Stiffler, H A Aslam, S Graur, G Bebko, J C Lockovich, M L Phillips
Young adults often experience psychological distress and poor quality of life (QoL). Yet, there are no objective neural markers to accurately guide interventions to help improve these measures. We thus aimed to identify directional relationships between frontoamygdala emotional regulation circuitry activity during emotion processing, personality traits, and symptoms associated with psychological distress, and QoL. One hundred twenty 18-25-year olds, n=51 psychologically distressed and n=69 healthy individuals, completed a face emotion-processing task during functional magnetic resonance imaging, clinical and behavioral measures, and QoL assessment...
July 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28741626/dopamine-and-stress-system-modulation-of-sex-differences-in-decision-making
#11
Polymnia Georgiou, Panos Zanos, Shambhu Bhat, J Kathleen Tracy, Istvan J Merchenthaler, Margaret M McCarthy, Todd D Gould
Maladaptive decision making is associated with several neuropsychiatric disorders, including problem gambling and suicidal behavior. The prevalence of these disorders is higher in men versus women, suggesting gender-dependent regulation of their pathophysiology underpinnings. We assessed sex differences in decision making using the rat version of the Iowa gambling task. Female rats identified the most optimal choice from session 1, while male rats from session 5. Male, but not female rats, progressively improved their advantageous option responding and surpassed females...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28741624/hormonal-cycle-and-contraceptive-effects-on-amygdala-and-salience-resting-state-networks-in-women-with-previous-affective-side-effects-on-the-pill
#12
Jonas Engman, Inger Sundström Poromaa, Lena Moby, Johan Wikström, Mats Fredrikson, Malin Gingnell
The mechanisms linking ovarian hormones to negative affect are poorly characterized, but important clues may come from the examination of the brain's intrinsic organization. Here, we studied the effects of both the menstrual cycle and oral contraceptives (OCs) on amygdala and salience network resting-state functional connectivity using a double-blind, randomized, and placebo-controlled design. Hormone levels, depressive symptoms, and resting-state functional connectivity were measured in 35 healthy women (24...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28740423/antinociceptive-tolerance-to-nsaids-in-the-agranular-insular-cortex-is-mediated-by-opioid-mechanism
#13
Natia Pirkulashvili, Nana Tsiklauri, Marina Nebieridze, Merab G Tsagareli
Several lines of investigations have shown that in some brain areas, in particular, in the midbrain periaqueductal gray matter, rostral ventromedial medulla, central nucleus of amygdala, nucleus raphe magnus, and dorsal hippocampus, microinjections of nonsteroidal anti-inflammatory drugs (NSAIDs) induce antinociception with distinct development of tolerance. The agranular insular cortex (AIC) is a small region of the cerebral cortex located on the lateral area of the rat's cerebral hemisphere that is involved in the perception and response to pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28740086/novel-molecule-exhibiting-selective-affinity-for-gabaa-receptor-subtypes
#14
Cecilia M Borghese, Melissa Herman, Lawrence D Snell, Keri J Lawrence, Hyun-Young Lee, Donald S Backos, Lauren A Vanderlinden, R Adron Harris, Marisa Roberto, Paula L Hoffman, Boris Tabakoff
Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABAA) receptors. DCUK-OEt was shown to be a positive allosteric modulator (PAM) of GABA currents with α1β2γ2, α1β3γ2, α5β3γ2 and α1β3δ GABAA receptors, while having no significant PAM effect on αβ receptors or α1β1γ2, α1β2γ1, α4β3γ2 or α4β3δ receptors...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739584/distinct-trajectories-of-cortisol-response-to-prolonged-acute-stress-are-linked-to-affective-responses-and-hippocampal-gray-matter-volume-in-healthy-females
#15
Roee Admon, Michael T Treadway, Linda Valeri, Malavika Mehta, Samuel Douglas, Diego A Pizzagalli
The development of robust laboratory procedures for acute stress induction over the last decades has greatly advanced our understanding of stress responses in humans and their underlying neurobiological mechanisms. Nevertheless, attempts to uncover linear relationships between endocrine, neural, and affective responses to stress have generally yielded inconsistent results. Here, 79 healthy females completed a well-established laboratory procedure of acute stress induction that was modified in order to prolong its effect...
July 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28739522/bimodal-odor-processing-with-a-trigeminal-component-at-sub-and-suprathreshold-levels
#16
Robert Pellegrino, Edda Drechsler, Cornelia Hummel, Johnathan Warr, Thomas Hummel
Odors are typically bimodal in nature, interacting with the olfactory and trigeminal systems. The trigeminal component may be noticed (e.g. menthol) or perceptually ignored, leading to different neural substrates being recruited during odor encoding. Therefore, the current study was designed to explore the perceptual and central-nervous activations in response to pleasant bimodal odors using functional magnetic resonance imaging (fMRI). In this study, healthy subjects were exposed to odorants alone (unimodal) or with a "cooling" trigeminal component (bimodal) at sub- and suprathreshold concentrations with a portable olfactometer in a 3 T fMRI scanner...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28738103/phobia-with-hallucinations-and-ptsd-can-amygdala-dysfunction-be-a-common-unified-lesion-in-the-rdoc-sense
#17
LaTonya Griffin, Nagy A Youssef
No abstract text is available yet for this article.
August 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28737295/towards-a-unified-analysis-of-brain-maturation-and-aging-across-the-entire-lifespan-a-mri-analysis
#18
Pierrick Coupé, Gwenaelle Catheline, Enrique Lanuza, José Vicente Manjón
There is no consensus in literature about lifespan brain maturation and senescence, mainly because previous lifespan studies have been performed on restricted age periods and/or with a limited number of scans, making results instable and their comparison very difficult. Moreover, the use of nonharmonized tools and different volumetric measurements lead to a great discrepancy in reported results. Thanks to the new paradigm of BigData sharing in neuroimaging and the last advances in image processing enabling to process baby as well as elderly scans with the same tool, new insights on brain maturation and aging can be obtained...
July 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28736521/group-level-progressive-alterations-in-brain-connectivity-patterns-revealed-by-diffusion-tensor-brain-networks-across-severity-stages-in-alzheimer-s-disease
#19
Javier Rasero, Carmen Alonso-Montes, Ibai Diez, Laiene Olabarrieta-Landa, Lakhdar Remaki, Iñaki Escudero, Beatriz Mateos, Paolo Bonifazi, Manuel Fernandez, Juan Carlos Arango-Lasprilla, Sebastiano Stramaglia, Jesus M Cortes
Alzheimer's disease (AD) is a chronically progressive neurodegenerative disease highly correlated to aging. Whether AD originates by targeting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. Here, we aim to provide an answer to this question at the group-level by looking at differences in diffusion-tensor brain networks. In particular, making use of data from Alzheimer's Disease Neuroimaging Initiative (ADNI), four different groups were defined (all of them matched by age, sex and education level): G1 (N1 = 36, healthy control subjects, Control), G2 (N2 = 36, early mild cognitive impairment, EMCI), G3 (N3 = 36, late mild cognitive impairment, LMCI) and G4 (N4 = 36, AD)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28736133/knockdown-of-zif268-in-the-posterior-dorsolateral-striatum-does-not-enduringly-disrupt-a-response-memory-of-a-rewarded-t-maze-task
#20
Emma N Cahill, George H Vousden, Marc T J Exton-McGuinness, Ian R C Beh, Casey B Swerner, Matej Macak, Sameera Abas, Cameron C Cole, Brian F Kelleher, Barry J Everitt, Amy L Milton
Under certain conditions pavlovian memories undergo reconsolidation, whereby the reactivated memory can be disrupted by manipulations such as knockdown of zif268. For instrumental memories, reconsolidation disruption is less well established. Our previous, preliminary data identified that there was an increase in Zif268 in the posterior dorsolateral striatum (pDLS) after expression of an instrumental habit-like 'response' memory, but not an instrumental goal-directed 'place' memory on a T-maze task. Here, the requirement for Zif268 in the reconsolidation of a response memory was tested by knockdown of Zif268, using antisense oligodeoxynucleotide infusion into the pDLS, at memory reactivation...
July 20, 2017: Neuroscience
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