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Asymptomatic bacteriuria

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https://www.readbyqxmd.com/read/29340148/reducing-unnecessary-culturing-a-systems-approach-to-evaluating-urine-culture-ordering-and-collection-practices-among-nurses-in-two-acute-care-settings
#1
Robert Redwood, Mary Jo Knobloch, Daniela C Pellegrini, Matthew J Ziegler, Michael Pulia, Nasia Safdar
Background: Inappropriate ordering and acquisition of urine cultures leads to unnecessary treatment of asymptomatic bacteriuria (ASB). Treatment of ASB contributes to antimicrobial resistance particularly among hospital-acquired organisms. Our objective was to investigate urine culture ordering and collection practices among nurses to identify key system-level and human factor barriers and facilitators that affect optimal ordering and collection practices. Methods: We conducted two focus groups, one with ED nurses and the other with ICU nurses...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29338897/asymptomatic-bacteriuria-and-urinary-tract-infection-in-pregnant-women-with-and-without-diabetes-cohort-study
#2
Caroline Schneeberger, Jan Jaap H M Erwich, Edwin R van den Heuvel, Ben W J Mol, Alewijn Ott, Suzanne E Geerlings
OBJECTIVE: To compare the prevalence of asymptomatic bacteriuria (ASB) and the incidence of urinary tract infection (UTI) in pregnant women with and without diabetes mellitus (DM) or gestational DM (GDM). STUDY DESIGN: We performed a cohort study in five hospitals and two midwifery clinics in the Netherlands. Pregnant women with and without DM or GDM were screened for the presence of ASB around 12 and 32 weeks' gestation. Characteristics of participants as well as outcome data were collected from questionnaires and medical records...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29331548/effect-of-outpatient-antibiotics-for-urinary-tract-infections-on-antimicrobial-resistance-among-commensal-enterobacteriaceae-a-multinational-prospective-cohort-study
#3
Andrew J Stewardson, Jascha Vervoort, Niels Adriaenssens, Samuel Coenen, Maciek Godycki-Cwirko, Anna Kowalczyk, Benedikt Huttner, Christine Lammens, Surbhi Malhotra-Kumar, Herman Goossens, Stephan Harbarth
OBJECTIVES: We quantified the impact of antibiotics prescribed in primary care for urinary tract infections (UTIs) on intestinal colonisation by ciprofloxacin-resistant (CIP-RE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE), while accounting for household clustering. METHODS: Prospective cohort study from January 2011 to August 2013 at primary care sites in Belgium, Poland and Switzerland. We recruited outpatients requiring antibiotics for suspected UTIs or asymptomatic bacteriuria (exposed patients), outpatients not requiring antibiotics (non-exposed patients), and 1-3 household contacts for each patient...
January 10, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29326206/whole-genome-draft-sequences-of-nine-asymptomatic-escherichia-coli-bacteriuria-isolates-from-diabetic-patients
#4
Christoph Stork, Beáta Kovács, Eva Trost, Tamás Kovács, György Schneider, Barnabás Rózsai, Monika Kerényi, Levente Emődy, Ulrich Dobrindt
Escherichia coli can colonize the urinary bladder without causing a disease response in the host. This asymptomatic bacteriuria (ABU) can protect against recurrent symptomatic urinary tract infection by virulent bacteria. Here, we report the whole-genome sequences of nine E. coli ABU isolates from diabetic patients.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29319624/long-term-outcome-of-one-step-kidney-transplantation-and-bladder-augmentation-procedure-in-pediatric-patients
#5
R Cleper, D Ben Meir, I Krause, P Livne, E Mor, M Davidovits, A Dagan
BACKGROUND: Guidelines for bladder augmentation (BA) in kidney transplant (KT) recipients are not well-defined. In our center, simultaneous BA with KT (BA-KT) is performed. We assessed transplantation outcomes of this unique extensive procedure. METHODS: A case-control single center retrospective study. Transplantation outcomes were compared with those of KT recipients who did not need BA. RESULTS: Compared to 22 patients who underwent KT only, for 9 who underwent BA-KT, surgical complications and the need for revision in the early posttransplantation period were similar; early graft function was better: estimated glomerular filtration rate (eGFR): 96...
January 10, 2018: Transplantation
https://www.readbyqxmd.com/read/29305250/diagnosis-and-treatment-of-urinary-tract-infections-across-age-groups
#6
REVIEW
Christine M Chu, Jerry L Lowder
Urinary tract infections (UTI) are the most common outpatient infections, but predicting the probability of UTI through symptoms and test results can be complex. The most diagnostic symptoms of UTI include change in frequency, dysuria, urgency, and presence or absence of vaginal discharge, but UTIs may present differently in older women. Dipstick urinalysis is popular for its availability and usefulness, but results must be interpreted in context of the patient's pretest probability based on symptoms and characteristics...
January 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29290000/evaluation-of-perioperative-prophylaxis-with-fosfomycin-tromethamine-in-ureteroscopic-stone-removal-an-investigator-driven-prospective-multicenter-randomized-controlled-study
#7
Lu-Dong Qiao, Shan Chen, Yun-Hua Lin, Jian-Xing Li, Wei-Guo Hu, Jian-Ping Hou, Liang Cui
PURPOSE: To compare efficacy, safety, and cost-effectiveness of fosfomycin tromethamine with other standard-of-care antibiotics in patients undergoing ureteroscopic lithotripsy. METHODS: This study was a prospective, multicenter, randomized, controlled trial. Eligible patients scheduled for ureteroscopic lithotripsy were randomly assigned to receive either fosfomycin (fosfomycin group, N = 101 patients) or standard-of-care antibiotic therapy as prophylaxis (control group, N = 115 patients)...
December 30, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29246012/characterization-of-the-urinary-microbiota-of-elderly-women-and-the-effects-of-type-2-diabetes-and-urinary-tract-infections-on-the-microbiota
#8
Fengping Liu, Zongxin Ling, Yonghong Xiao, Qing Yang, Li Zheng, Ping Jiang, Lanjuan Li, Wei Wang
Evidence shows that urine has complex bacterial profiles with considerable variation between individuals. Aging and age-related conditions can lead to the changes to the composition of urine, which means that the available nutrition for bacteria in the bladder changes with age. We explored the characteristics of the urinary microbiota of elderly women and whether these are associated with age-related conditions such as diabetes and urinary tract infections. An elderly and a non-elderly cohort of women were included...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243301/evaluation-of-the-live-biotherapeutic-product-asymptomatic-bacteriuria-escherichia-coli-2-12-in-healthy-dogs-and-dogs-with-clinical-recurrent-uti
#9
G Segev, J E Sykes, D J Klumpp, A J Schaeffer, E M Antaki, B A Byrne, R E Yaggie, J L Westropp
BACKGROUND: Antimicrobial resistance is an emerging problem. HYPOTHESIS/OBJECTIVE: To investigate the safety and efficacy of a live biotherapeutic product, ASB E. coli 2-12 for UTI treatment. ANIMALS: Six healthy research dogs; nine client-owned dogs with recurrent UTI. METHODS: Prospective noncontrolled clinical trial. For safety data, research dogs were sedated, a urinary catheter was inserted into the bladder; 1010 CFU/mL of ASB E...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29228072/an-implementation-guide-to-reducing-overtreatment-of-asymptomatic-bacteriuria
#10
Michael Daniel, Sara Keller, Mohammad Mozafarihashjin, Amit Pahwa, Christine Soong
Treatment of asymptomatic bacteriuria (ASB) frequently lacks appropriate indication, yet remains prevalent across settings. Numerous guidelines, professional societies, and campaigns such as Choosing Wisely advocate against this low-value practice. Efforts aimed at reducing unnecessary treatment of ASB demonstrate improved costs, and avoidable harm without increased risk of adverse events. We propose an evidence-based implementation guide to aid practitioners in reducing inappropriate treatment of ASB.
December 11, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29226170/inappropriate-management-of-asymptomatic-patients-with-positive-urine-cultures-a-systematic-review-and-meta-analysis
#11
Myrto Eleni Flokas, Nikolaos Andreatos, Michail Alevizakos, Alireza Kalbasi, Pelin Onur, Eleftherios Mylonakis
Background: Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods: We conducted a systematic review and meta-analysis of studies that reported on the rate of inappropriate ASB treatment published from 2004 to August 2016. The appropriateness of antimicrobial administration was based on guidelines published by the Infectious Diseases Society of America...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29224913/re-is-preoperative-assessment-and-treatment-of-asymptomatic-bacteriuria-necessary-for-reducing-the-risk-of-postoperative-symptomatic-urinary-tract-infection-after-urologic-surgical-procedures
#12
https://www.readbyqxmd.com/read/29183930/reducing-catheter-associated-urinary-tract-infections-in-hospitals-study-protocol-for-a-multi-site-randomised-controlled-study
#13
Brett G Mitchell, Oyebola Fasugba, Anne Gardner, Jane Koerner, Peter Collignon, Allen C Cheng, Nicholas Graves, Peter Morey, Victoria Gregory
INTRODUCTION: Despite advances in infection prevention and control, catheter-associated urinary tract infections (CAUTIs) are common and remain problematic. A number of measures can be taken to reduce the risk of CAUTI in hospitals. Appropriate urinary catheter insertion procedures are one such method. Reducing bacterial colonisation around the meatal or urethral area has the potential to reduce CAUTI risk. However, evidence about the best antiseptic solutions for meatal cleaning is mixed, resulting in conflicting recommendations in guidelines internationally...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29177489/disease-based-antimicrobial-stewardship-a-review-of-active-and-passive-approaches-to-patient-management
#14
Farnaz Foolad, Jerod L Nagel, Gregory Eschenauer, Twisha S Patel, Cynthia T Nguyen
Although new antimicrobial stewardship programmes (ASPs) often begin by targeting the reduction of antimicrobial use, an increasing focus of ASPs is to improve the management of specific infectious diseases. Disease-based antimicrobial stewardship emphasizes improving patient outcomes by optimizing antimicrobial use and increasing compliance with performance measures. Directing efforts towards the comprehensive management of specific infections allows ASPs to promote the shift in healthcare towards improving quality, safety and patient outcome metrics for specific diseases...
December 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29174023/antibiotic-treatment-of-asymptomatic-bacteriuria-prior-to-hip-and-knee-arthroplasty-a-systematic-review-of-the-literature
#15
REVIEW
Alistair I W Mayne, Peter S E Davies, James M Simpson
BACKGROUND: There is significant debate as to whether routine antibiotic treatment of asymptomatic bacteriuria (ASB) in arthroplasty patients reduces the risk of subsequent PJI. No previous systematic reviews have been undertaken on this subject. The aim of this systematic review was to investigate whether antibiotic treatment of asymptomatic bacteriuria in arthroplasty patients reduces the risk of prosthetic joint infection and to investigate whether the organisms cultured in peri-operative urine samples are the same as those responsible for subsequent prosthetic joint infections...
November 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29170899/preoperative-urine-culture-is-unnecessary-in-asymptomatic-men-prior-to-prostate-needle-biopsy
#16
David Z Qi, Kathleen Lehman, Kalyan Dewan, Girish Kirimanjeswara, Jay D Raman
PURPOSE: To determine the clinical utility of preoperative urine cultures in asymptomatic men undergoing prostate needle biopsy (PNB). METHODS: One hundred fifty asymptomatic men had urine cultures obtained 14-days prior to PNB. As per study protocol, positive cultures were not treated. Antibiotic prophylaxis prior to PNB included ciprofloxacin 500 mg the night before and morning of the biopsy. Repeat urine cultures were obtained immediately prior to PNB with colony-forming units (CFUs) annotated...
November 23, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29149963/urinary-tract-infections-in-the-first-year-post-kidney-transplantation-potential-benefits-of-treating-asymptomatic-bacteriuria
#17
P Kotagiri, D Chembolli, J Ryan, P D Hughes, N D Toussaint
BACKGROUND: Urinary tract infections (UTIs) are the commonest infectious complication in kidney transplant recipients (KTRs). No recommendations exist regarding treatment of asymptomatic bacteriuria. We aimed to identify potential risk factors and microbiological profile for UTIs, the role of treatment of asymptomatic bacteriuria, and effects on graft outcomes of bacteriuria within the first year post-transplantation. METHODS: We performed a retrospective analysis of UTIs in KTRs transplanted between January 2012 and December 2013 in 2 transplantation centers...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29129031/evaluation-and-management-of-staphylococcus-aureus-bacteriuria-an-updated-review
#18
REVIEW
Stamatis Karakonstantis, Dimitra Kalemaki
BACKGROUND AND AIMS: There is little guidance regarding the evaluation and management of patients with Staphylococcus aureus bacteriuria (SABU). Here, we aimed to provide an up-to-date review of the literature. METHODS: We searched PubMed, Scopus, and clinical trial registries for articles evaluating the epidemiology of SABU, risk factors of SABU, the association of SABU with urinary tract infection, bacteremia and invasive S. aureus infections, and the management of patients with SABU...
November 11, 2017: Infection
https://www.readbyqxmd.com/read/29099028/post-stroke-bacteriuria-a-longitudinal-study-among-stroke-outpatients-and-inpatients-at-the-korle-bu-teaching-hospital-in-ghana
#19
Eric S Donkor, Samuel Darkwah, Albert Akpalu
Infections of the urinary tract constitute an important post-stroke complication but in Africa, little is known about such infections in relation to stroke patients. The aim of the study was to investigate the epidemiology of bacteriuria among stroke patients at the Korle-Bu Teaching Hospital (KBTH) in Ghana including the prevalence, incidence, risk factors and aetiological agents. This was a longitudinal study involving 55 outpatients and 16 inpatients of stroke from the physiotherapy clinic and stroke admission ward of KBTH respectively...
June 2, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29079155/urinary-tract-infection-and-asymptomatic-bacteriuria-in-older-adults
#20
REVIEW
Nicolas W Cortes-Penfield, Barbara W Trautner, Robin L P Jump
Urinary tract infections (UTIs) are a significant cause of morbidity among older adults. However, antibiotic prescriptions for clinically suspected UTIs are often inappropriate. Health care providers frequently struggle to differentiate UTI from asymptomatic bacteriuria, particularly in patients presenting with nonspecific symptoms. Patients with baseline cognitive impairments that limit history-taking can be particularly challenging. This article reviews the epidemiology and pathogenesis of UTI in older adults...
December 2017: Infectious Disease Clinics of North America
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