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https://www.readbyqxmd.com/read/29788185/cyclophosphamide-induced-disruptions-to-appetitive-qualities-and-detection-thresholds-of-nacl-comparison-of-single-dose-and-dose-fractionation-effects
#1
Benjamin C Jewkes, Michael G Gomella, Evan T Lowry, Joy A Benner, Eugene R Delay
Chemotherapy is one of the most common treatments for cancer, however a side effect is often altered taste. This study examined how cyclophosphamide, a chemotherapy drug, affects salt taste in mice. Based on previous findings, it was predicted that cyclophosphamide-induced disruptions in salt taste would be observed near days 2-4, 8-12, and 22-24 days post treatment, and that multiple, smaller doses would cause more severe disruptions to taste. To test these predictions, two experiments were performed, one using brief access testing to measure appetitive qualities, and another using operant conditioning to measure detection thresholds...
May 19, 2018: Chemical Senses
https://www.readbyqxmd.com/read/29786652/consumer-perception-of-the-quality-of-lamb-and-lamb-confit
#2
Guillermo Ripoll, Margalida Joy, Begoña Panea
The patterns of food consumption in general and those of meat, in particular, are constantly changing. These changes are due not only to socioeconomic and cultural trends that affect the whole society but also to the specific lifestyles of consumer groups. Due to the importance of consumer lifestyle, the objectives of this study were (i) to identify the profiles of lamb meat consumers according to their orientation toward convenience, as defined by their eating and cooking habits; (ii) to characterize these profiles according to their socioeconomic characteristics and their preferences regarding the intrinsic and extrinsic quality signals of lamb meat; and (iii) to analyze the willingness to pay for lamb confit...
May 22, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29785787/expanding-systems-thinking-incorporating-tools-from-medical-sociology-into-mft-education-and-research
#3
Joy Heafner, Laura Mauldin
The field of marriage and family therapy has historically focused on dynamics within family systems, and at times the role of social and cultural factors external to the family. To date, however, little scholarship has examined how therapists themselves are embedded within a mental healthcare system. The purpose of this article is to demonstrate how structural components of the mental healthcare system shape the practice of therapy. We draw from the field of medical sociology to illustrate how three dominant structures-managed care, diagnosis, and evidence-based models-are intertwining and mutually reinforcing systems that have significant and long-term implications for systemic therapists and researchers...
May 21, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29784646/latest-developments-in-muc1-immunotherapy
#4
REVIEW
Joyce Taylor-Papadimitriou, Joy M Burchell, Rosalind Graham, Richard Beatson
Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas. Moreover, MUC1 is expressed by some haematopoietic cancers, including acute myeloid leukaemia and myeloma. Although multiple clinical trials have been initiated and immune responses have been documented, effective clinical benefit worthy of approval for general application has not as yet been achieved...
May 21, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29782309/in-memoriam-assistant-professor-kre%C3%A5-imir-kostovi%C3%A4-md-phd-16-october-1969-15-october-2017
#5
Branka Marinović
On a Sunday afternoon almost six months ago, we were deeply moved by the news that our Krešimir is no longer with us. The sad news spread from Sarajevo with the speed only most horrible and saddest news can achieve. And everybody who was reached by these news wondered whether it was possible and whether it was true. Because our professor Kostović left us a day before his 48th birthday. Krešimir Kostović was born on the 16th October 1969 in Zagreb, where he completed primary and secondary education. He enrolled at the University of Zagreb School of Medicine in 1988, and got his medical degree in 1995...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781858/axillary-lymphadenectomy-and-wound-complications-in-implant-based-breast-reconstruction
#6
Matthew T Joy, Matthew D Rich, Kurtis E Moyer
BACKGROUND: The most common method of breast reconstruction in the United States today is implant-based reconstruction. However, reported complication rates are high, from 30% to 50%. Thus, it is important for reconstructive surgeons to identify factors associated with or contributing to wound complications after breast reconstruction. This study sought to identify associations between axillary lymph node dissection and postoperative wound complications in implant-based breast reconstruction...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29780819/a-comprehensive-review-of-the-pharmacologic-management-of-uterine-leiomyoma
#7
REVIEW
Terrence D Lewis, Minnie Malik, Joy Britten, Angelo Macapagal San Pablo, William H Catherino
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29779732/music-dance-and-other-art-forms-new-insights-into-the-links-between-hedonia-pleasure-and-eudaimonia-well-being
#8
Eloise A Stark, Peter Vuust, Morten L Kringelbach
For Aristotle, the goal of human life was to live well, to flourish, and to ultimately have a good life. These goals can be conceptualized as "eudaimonia," a concept distinct from "hedonia" (pleasure). Many people would argue that the arts play a large role in their well-being and eudaimonia. Music in particular is a culturally ubiquitous phenomenon which brings joy and social bonding to listeners. Research has given insights into how the "sweet anticipation" of music and other art forms can lead to pleasure, but a full understanding of eudaimonia from the arts is still missing...
2018: Progress in Brain Research
https://www.readbyqxmd.com/read/29778784/food-choice-considerations-among-american-indians-living-in-rural-oklahoma-the-thrive-study
#9
Marianna S Wetherill, Mary B Williams, Micah L Hartwell, Alicia L Salvatore, Tvli Jacob, Tamela K Cannady, Joy Standridge, Jill Fox, Jennifer Spiegel, Natia Anderson, Valarie Blue Bird Jernigan
In rural American Indian (AI) communities, access to affordable, healthy foods is often limited. Understanding AI food choice considerations when selecting foods, such as sensory appeal, cost, or health, is an important yet understudied topic for eliminating persistent AI health disparities. In partnership with the Chickasaw Nation and Choctaw Nation of Oklahoma, we administered a modified version of the Food Choice Values (FCV) Questionnaire to a cross-sectional sample of 83 AI patrons shopping at tribally-owned convenience stores ≥3 times per week...
May 17, 2018: Appetite
https://www.readbyqxmd.com/read/29777659/adopting-the-quadruple-aim-the-university-of-rochester-medical-center-experience-%C3%A2-%C3%A2-%C3%A2-moving-from-physician-burnout-to-physician-resilience
#10
Allen P Anandarajah, Timothy E Quill, Michael R Privitera
BACKGROUND: The high rates of burnout among medical professionals in the US are well documented. The reasons for burnout and the factors that contribute to physician resilience among healthcare providers in academic centers however are less well studied. METHODS: Healthcare providers at a large academic center were surveyed to measure degree of burnout and callousness and identify associated factors. Additional questions evaluated the features linked to resilience...
May 16, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29773938/correlations-between-a1c-and-diabetes-knowledge-diabetes-numeracy-and-food-security-in-a-vulnerable-type-2-diabetes-population
#11
Clipper F Young, Kenneth Yun, Edward Kang, Jay H Shubrook, Joy A Dugan
Type 2 diabetes is over-represented in vulnerable populations. Vulnerable patients managing diabetes are challenged with less-than-optimal processes and outcomes of care; thus, Healthy People 2020 and the American Diabetes Association have renewed the focus on social determinants of health with regard to the management of chronic diseases such as diabetes. This study explored the correlations between A1C and social and personal factors, including diabetes knowledge, diabetes numeracy, and food security. The Diabetes Numeracy Test-15, the Spoken Knowledge in Low Literacy Diabetes Scale, and the U...
May 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29771599/clinical-characterization-of-children-with-resistant-airflow-obstruction-a-multicenter-study
#12
Sankaran Krishnan, Allen J Dozor, Leonard Bacharier, Jason E Lang, Charles G Irvin, David Kaminsky, Harold J Farber, Lynn Gerald, Mark Brown, Janet T Holbrook, Robert A Wise, Julie Ryu, Sonali Bose, Yasin Razan, Joy Saams, Robert J Henderson, William G Teague
OBJECTIVE: To characterize a cohort of children with airflow limitation resistant to bronchodilator (BD) therapy. METHODS: Pulmonary function tests performed in children 6-17 years of age at 15 centers in a clinical research consortium were screened for resistant airflow limitation, defined as a post-BD FEV1 and/or an FEV1 /FVC less than the lower limits of normal. Demographic and clinical data were analyzed for associations with pulmonary function. RESULTS: 582 children were identified...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29771557/distress-tolerance-associations-with-trauma-and-substance-cue-reactivity-in-low-income-inner-city-adults-with-substance-use-disorders-and-posttraumatic-stress
#13
Anka A Vujanovic, Margaret C Wardle, Jafar Bakhshaie, Lia J Smith, Charles E Green, Scott D Lane, Joy M Schmitz
Cue reactivity has great potential to advance our understanding of posttraumatic stress disorder (PTSD), substance use disorder (SUD), and PTSD/SUD comorbidity. The present investigation examined distress tolerance (DT) with regard to trauma and substance cue reactivity. Participants included 58 low-income, inner-city adults (49.1% women; Mage = 45.73, SD = 10.00) with substance dependence and at least 4 symptoms of PTSD. A script-driven cue reactivity paradigm was utilized. Four DT measures were administered, including the Distress Tolerance Scale (DTS), Mirror-Tracing Persistence Task (MTPT), Breath-Holding Task (BH), and Paced Auditory Serial Addition Task (PASAT)...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29767568/the-relationship-between-intuitive-action-choices-and-moral-reasoning-on-animal-ethics-issues-in-students-of-veterinary-medicine-and-other-relevant-professions
#14
Joy M Verrinder, Clive J C Phillips
With growing understanding of animals' capabilities, and public and organizational pressures to improve animal welfare, moral action by veterinarians and other relevant professionals to address animal issues is increasingly important. Little is known about how their action choices relate to their moral reasoning on animal ethics issues. A moral judgment measure, the VetDIT, with three animal and three non-animal scenarios, was used to investigate the action choices of 619 students in five animal- and two non-animal-related professional programs in one Australian university, and how these related to their moral reasoning based on Personal Interest (PI), Maintaining Norms (MN), or Universal Principles (UP) schemas...
2018: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/29767413/the-statistical-joys-and-added-complications-of-twin-studies
#15
James A Hanley
No abstract text is available yet for this article.
May 16, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29767395/behavioral-therapy-approaches-for-the-management-of-low-back-pain-an-up-to-date-systematic-review
#16
REVIEW
Kristallia Vitoula, Annalena Venneri, Giustino Varrassi, Antonella Paladini, Panagiota Sykioti, Joy Adewusi, Panagiotis Zis
Low back pain is one of the most common causes for seeking medical treatment and it is estimated that one in two people will experience low back pain at some point during their lifetimes. Management of low back pain includes pharmacological and non-pharmacological approaches. Non-pharmaceutical treatments include interventions such as acupuncture, spinal manipulation, and psychotherapy. The latter is especially important as patients who suffer from low back pain often have impaired quality of life and also suffer from depression...
May 16, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29764464/daytime-and-nighttime-casein-supplements-similarly-increase-muscle-size-and-strength-in-response-to-resistance-training-earlier-in-the-day-a-preliminary-investigation
#17
Jordan M Joy, Roxanne M Vogel, K Shane Broughton, Urszula Kudla, Nathaniel Y Kerr, Jason M Davison, Robert E C Wildman, Nancy M DiMarco
BACKGROUND: Casein protein consumed before sleep has been suggested to offer an overnight supply of exogenous amino acids for anabolic processes. The purpose of this study was to compare supplemental casein consumed earlier in the day (DayTime, DT) versus shortly before bed (NightTime, NT) on body composition, strength, and muscle hypertrophy in response to supervised resistance training. METHODS: Thirteen males participated in a 10-week exercise and dietary intervention while receiving 35 g casein daily...
May 15, 2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29764305/pregnancy-experiences-of-women-in-rural-romania-understanding-ethnic-and-socioeconomic-disparities
#18
Katherine LeMasters, Anne Baber Wallis, Razvan Chereches, Margaret Gichane, Ciprian Tehei, Andreea Varga, Katherine Tumlinson
Women in rural Romania face significant health disadvantages. This qualitative pilot study describes the structural disadvantage experienced during pregnancy by women in rural Romania, focusing on the lived experiences of Roma women. We explore how women in rural communities experience pregnancy, their interactions with the healthcare system, and the role that ethnic and social factors play in pregnancy and childbearing. We conducted 42 semi-structured interviews with health and other professionals, seven narrative interviews with Roma and non-Roma women and a focus group with Roma women...
May 15, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29763378/characterization-of-thermally-activated-metalloenediyne-cytotoxicity-in-human-melanoma-cells
#19
Eric J Keller, Meghan Porter, Joy E Garrett, Meredith Varie, Haiyan Wang, Karen E Pollok, John J Turchi, Jeffrey M Zaleski, Joseph R Dynlacht
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity. We previously demonstrated that cytotoxicity of two different metalloenediynes, including (Z)-N,N'-bis[1-pyridyl-2-yl-meth-(E)-ylidene]octa-4-ene-2,6-diyne-1,8-diamine] (PyED), is potentiated when the compounds are administered to HeLa cells during hyperthermia treatment at concentrations that are minimally or not cytotoxic at 37°C. In this study, we further characterized the concentration, time and temperature dependence of cytotoxicity of PyED on human U-1 melanoma cells...
May 15, 2018: Radiation Research
https://www.readbyqxmd.com/read/29762264/achieving-guideline-driven-high-intensity-statin-dose-in-cardiac-rehabilitation-patients-with-coronary-artery-disease
#20
Jonathan Lin, Alexandra Banathy, Carla Winters, Lars Andersen, Cindy Hudson, Heidi Testa, Joy Reardon, Peter Alagona
PURPOSE: The 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommends high-intensity statin therapy in patients aged ≤75 y with clinical coronary artery disease (CAD). The effectiveness of cardiac rehabilitation (CR) in lipid management and guideline adherence is unknown. The purpose of this study is to determine whether CR participation affects guideline-driven achievement for statin use...
May 12, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
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