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https://www.readbyqxmd.com/read/28333723/managing-medication-errors
#1
Joy Satorre
No abstract text is available yet for this article.
April 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28332616/long-acting-protein-drugs-for-the-treatment-of-ocular-diseases
#2
Joy G Ghosh, Andrew A Nguyen, Chad E Bigelow, Stephen Poor, Yubin Qiu, Nalini Rangaswamy, Richard Ornberg, Brittany Jackson, Howard Mak, Tucker Ezell, Vania Kenanova, Elisa de la Cruz, Ana Carrion, Bijan Etemad-Gilbertson, Roxana Garcia Caro, Kan Zhu, Vinney George, Jirong Bai, Radhika Sharma-Nahar, Siyuan Shen, Yiqin Wang, Kulandayan K Subramanian, Elizabeth Fassbender, Michael Maker, Shawn Hanks, Joanna Vrouvlianis, Barrett Leehy, Debby Long, Melissa Prentiss, Viral Kansara, Bruce Jaffee, Thaddeus P Dryja, Michael Roguska
Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal vascular diseases. Nonetheless, optimal visual outcomes require intraocular injections as frequently as every month. Here we report a method to extend the intravitreal half-life of protein drugs as an alternative to either encapsulation or chemical modifications with polymers. We combine a 97-amino-acid peptide of human origin that binds hyaluronan, a major macromolecular component of the eye's vitreous, with therapeutic antibodies and proteins...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28332036/the-committed-intimate-partnerships-of-incarcerated-african-american-men-implications-for-sexual-hiv-transmission-risk-and-prevention-opportunities
#3
Maria R Khan, Nabila El-Bassel, Carol E Golin, Joy D Scheidell, Adaora A Adimora, Ashley M Coatsworth, Hui Hu, Selena Judon-Monk, Katie P Medina, David A Wohl
Incarceration is thought to influence HIV transmission by disrupting partnerships that provide support and protect against sex risk-taking. Current correctional facility-based family-strengthening programs focus on marital partnerships, a minority of inmates' partnerships. Research on the sex partnerships of incarcerated African-American men and the types of partnerships most likely to protect against HIV-related sex risk is limited. Improved understanding can inform expansion of correctional facility-based family-strengthening programs to a greater proportion of protective partnerships and HIV risk reduction programs to partnerships vulnerable to sex risk...
March 22, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28331249/effectiveness-of-mind-mapping-technique-in-information-retrieval-among-medical-college-students-in-puducherry-a-pilot-study
#4
Madhanraj Kalyanasundaram, Sherin Billy Abraham, Divija Ramachandran, Venkatachalam Jayaseelan, Joy Bazroy, Zile Singh, Anil Jacob Purty
BACKGROUND: The traditional teaching learning methods involve a one way process of transmission of knowledge leaving the students lacking behind in creative abilities. Medical schools need to change their teaching strategies to keep the interest of students and empower them for future self- learning and critical thinking. OBJECTIVE: To assess the impact of mind mapping technique in information retrieval among medical college students in Puducherry. METHODS: A pilot study was conducted using experimental study design among sixth semester MBBS students (n = 64) at a medical college in Puducherry, India...
January 2017: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/28331061/an-intracellular-matrix-metalloproteinase-2-isoform-induces-tubular-regulated-necrosis-implications-for-acute-kidney-injury
#5
Carla S Ceron, Celine Baligand, Sunil K Joshi, Shaynah Wanga, Patrick M Cowley, Joy P Walker, Sang Heon Song, Rajeev Mahimkar, Anthony J Baker, Robert L Raffai, Zhen J Wang, David H Lovett
Acute kidney injury (AKI) causes severe morbidity, mortality, and chronic kidney disease (CKD). Mortality is particularly marked in the elderly and with pre-existing CKD. Oxidative stress is a common theme in models of AKI induced by ischemia/reperfusion (I/R) injury. We recently characterized an intracellular isoform of matrix metalloproteinase-2 (MMP-2) induced by oxidative stress-mediated activation of an alternate promoter in the first intron of the MMP-2 gene. This generates an N-terminal truncated MMP-2 isoform (NTT-MMP-2) that is intracellular and associated with mitochondria...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28330198/pretreatment-and-enzymatic-process-modification-strategies-to-improve-efficiency-of-sugar-production-from-sugarcane-bagasse
#6
Siddhartha Pal, Shereena Joy, Kalpana D Trimukhe, Pramod S Kumbhar, Anjani J Varma, Sasisanker Padmanabhan
Pretreatment and enzymatic hydrolysis play a critical role in the economic production of sugars and fuels from lignocellulosic biomass. In this study, we evaluated diverse pilot-scale pretreatments and different post-pretreatment strategies for the production of fermentable sugars from sugarcane bagasse. For the pretreatment of bagasse at pilot-scale level, steam explosion without catalyst and combination of sulfuric and oxalic acids at low and high loadings were used. Subsequently, to enhance the efficiency of enzymatic hydrolysis of the pretreated bagasse, three different post-pretreatment process schemes were investigated...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329857/-play-and-people-living-with-dementia-a-humanities-based-inquiry-of-timeslips-and-the-alzheimer-s-poetry-project
#7
Aagje Swinnen, Kate de Medeiros
This paper is a humanities-based inquiry, applying Huizinga's framework of homo ludens ("man the player") to consider "play" in the context of two participatory arts programs (TimeSlips and the Alzheimer's Poetry Project) for people living with dementia. "Play," according to this Dutch historian, is at the heart of human activity and what gives meaning to life. Despite empirical research on play across the life course, play in dementia care is a relatively new idea. In addition, there is a dearth of reports based on humanistic inquiry which has slightly different goals than the growing body of qualitative and quantitative studies of participatory arts interventions...
January 18, 2017: Gerontologist
https://www.readbyqxmd.com/read/28327403/calculation-of-age-and-gender-related-non-hdl-c-centiles-from-the-2003-and-2013-health-survey-for-england-data-implications-for-diagnosis-of-fh
#8
A Joy Allen, Michael Power, Julie Day, Jennifer S Mindell, Shaun Scholes, R Dermot G Neely
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28326868/a-longitudinal-study-assessing-the-maintenance-condition-of-cadres-of-four-types-of-wheelchairs-provided-in-low-resource-areas
#9
Karen Rispin, Kristofer Riseling, Joy Wee
Wheelchair breakdowns increase the risk of injury and limit the mobility of wheelchair users. In the endeavour to meet the enormous global need for wheelchairs, manufacturers of wheelchairs for low-resource settings face a cost-benefit tension between affordability and durability. Field studies are needed to provide feedback on durability. Four manufacturers provided cadres of wheelchairs to the organization providing rehabilitation to students at a boarding school for children with disabilities in a low-resource area...
March 22, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28325403/infraorbital-cutaneous-horn
#10
Divya Shenoy, Joy King, Julie P Wyatt, Robert T Brodell
No abstract text is available yet for this article.
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28325245/south-east-asia-differing-socioeconomic-factors-differing-access-to-radiotherapy-the-philippines-a-microcosm
#11
REVIEW
Miriam Joy C Calaguas, Johannes A Gubat
The accessibility of radiotherapy in Southeast Asia, a region characterized by diversity in both economy and culture, differ widely among its member countries. In most countries, access is not universal and is generally limited by radiotherapy resources and the health-seeking behavior of patients. This in turn relates to the current health policy in place, the practice of radiation oncology, and cultural factors such as religion and family dynamics. Although it is clear that radiotherapy access parallel economic development, it is also affected by different social factors that work to facilitate or impede its improvement...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28320784/mechanisms-to-mitigate-the-tradeoff-between-growth-and-defense
#12
Talia Karasov, Eunyoung Chae, Jacob Herman, Joy Bergelson
Plants have evolved an array of defenses against pathogens. However, mounting a defense response frequently comes with the cost of a reduction in growth and reproduction, carrying critical implications for natural and agricultural populations. How costs are generated, and whether and how they can be mitigated is the focus of this review. Most well-characterized growth-defense tradeoffs stem from antagonistic crosstalk among hormones rather than an identified metabolic expenditure. A primary way plants mitigate such costs is through restricted expression of resistance; this can be achieved through inducible expression of defense genes or by the concentration of defense to particular times or tissues...
March 20, 2017: Plant Cell
https://www.readbyqxmd.com/read/28320590/multitep-platform-based-dna-epitope-vaccine-targeting-n-terminus-of-tau-induces-strong-immune-responses-and-reduces-tau-pathology-in-thy-tau22-mice
#13
Hayk Davtyan, Wesley W Chen, Karen Zagorski, Joy Davis, Irina Petrushina, Konstantin Kazarian, David H Cribbs, Michael G Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan
BACKGROUND: By the time clinical symptoms of Alzheimer's disease (AD) manifest in patients there is already substantial tau pathology in the brain. Recent evidence also suggests that tau pathology can become self-propagating, further accelerating disease progression. Over the last decade several groups have tested the efficacy of protein-based anti-tau immunotherapeutics in various animal models of tauopathy. Here we report on the immunological and therapeutic potency of the first anti-tau DNA vaccine based on the MultiTEP platform, AV-1980D, in THY-Tau22 transgenic mice...
March 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28319475/advances-in-obstetric-anesthesia
#14
Joy L Hawkins
No abstract text is available yet for this article.
March 17, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28319354/when-joy-turns-to-anxiety-parental-experience-with-counselling-after-prenatal-diagnosis-of-congenital-anomaly
#15
EDITORIAL
Nathalie R Webb
No abstract text is available yet for this article.
April 2017: BJU International
https://www.readbyqxmd.com/read/28315744/cardiac-implantable-electronic-device-infections-who-is-at-greatest-risk
#16
Parijat Saurav Joy, Gagan Kumar, Jeanne E Poole, Barry London, Brian Olshansky
BACKGROUND: Cardiac Implantable Electronic Device (CIED) infections are associated with hospitalization, mortality, increased costs and adverse outcomes. OBJECTIVE: Determine the burden of infections for CIEDs based on device type, associated comorbidities and clinical characteristics over a 12-year period. METHODS: Utilizing the National Inpatient Sample database from 2000-2012, procedures for device related infection (DRI) were identified using ICD-9-CM code for CIED removal with diagnosis codes for device-related infection or systemic infection...
March 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28315742/association-of-nitric-oxide-synthase2-gene-polymorphisms-with-leprosy-reactions-in-northern-indian-population
#17
Amit Dubey, Sanjay Kumar Biswas, Ekata Sinha, Joy Kumar Chakma, Raj Kamal, Mamta Arora, Harish Sagar, Mohan Natarajan, Sameer S Bhagyawant, Keshar Kunja Mohanty
The pathogen Mycobacterium leprae causes leprosy that affects mainly skin and nerves. Polymorphisms of certain genes are substantiated to be associated with the susceptibility/resistance to leprosy. The present investigation addressed the association of Nitric Oxide Synthase2 gene polymorphisms and leprosy in a population from northern part of India. A total of 323 leprosy cases and 288 healthy controls were genotyped for four NOS2 promoter variants (rs1800482, rs2779249, rs8078340 and rs2301369) using FRET technology in Real Time PCR...
March 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28314374/hiv-1-consensus-envelope-induced-broadly-binding-antibodies
#18
R Ryan Meyerhoff, Richard M Scearce, Damon F Ogburn, Brad Lockwood, Joy Pickeral, Masa Kuraoka, Kara Anasti, Joshua Eudailey, Amanda Eaton, Melissa Cooper, Kevin Wiehe, David C Montefiori, Georgia D Tomaras, Guido Ferrari, S Munir Alam, Hua-Xin Liao, Bette Korber, Feng Gao, Barton F Haynes
Antibodies that cross-react with multiple HIV-1 envelopes (Envs) are useful reagents for characterizing Env proteins and for soluble Env capture and purification assays. We previously reported ten murine monoclonal antibodies induced by group M consensus Env, CON-6 immunization. Each demonstrated broad cross-reactivity to recombinant Envs. Here we characterized the Env epitopes to which they bind. Seven mapped to linear epitopes in gp120, five at the Env N-terminus and two at the Env C-terminus. One antibody, 13D7, bound at the gp120 N-terminus (aa 30-42), reacted with HIV-1-infected CD4+ T cells, and when expressed in a human IgG1 backbone, mediated ADCC...
March 17, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28303347/genome-wide-enrichment-of-damaging-de-novo-variants-in-patients-with-isolated-and-complex-congenital-diaphragmatic-hernia
#19
Mauro Longoni, Frances A High, Hongjian Qi, Maliackal P Joy, Regis Hila, Caroline M Coletti, Julia Wynn, Maria Loscertales, Linshan Shan, Carol J Bult, Jay M Wilson, Yufeng Shen, Wendy K Chung, Patricia K Donahoe
Congenital Diaphragmatic Hernia (CDH) is a common and often lethal birth defect characterized by diaphragmatic structural defects and pulmonary hypoplasia. CDH is isolated in 60% of newborns, but may also be part of a complex phenotype with additional anomalies. We performed whole exome sequencing (WES) on 87 individuals with isolated or complex CDH and on their unaffected parents, to assess the contribution of de novo mutations in the etiology of diaphragmatic and pulmonary defects and to identify new candidate genes...
March 16, 2017: Human Genetics
https://www.readbyqxmd.com/read/28303276/a-parameterized-ultrasound-based-finite-element-analysis-of-the-mechanical-environment-of-pregnancy
#20
Andrea R Westervelt, Michael Fernandez, Michael House, Joy Vink, Chia-Ling Nhan-Chang, Ronald Wapner, Kristin M Myers
Preterm birth is the leading cause of childhood mortality, and can lead to health risks in survivors. The mechanical function of the uterus, fetal membranes, and cervix have dynamic roles to protect the fetus during gestation. To understand their mechanical function and relation to preterm birth, we built a 3-dimensional parameterized finite element model of pregnancy. This model is generated by an automated procedure that is informed by maternal ultrasound measurements. A baseline model at 25 weeks of gestation was characterized, and to visualize the impact of cervical structural parameters on tissue stretch we evaluated the model sensitivity to: (1) anterior uterocervical angle, (2) cervical length, (3) posterior cervical offset, and (4) cervical stiffness...
March 17, 2017: Journal of Biomechanical Engineering
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