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https://www.readbyqxmd.com/read/29675292/linear-array-based-real-time-photoacoustic-imaging-system-with-a-compact-coaxial-excitation-handheld-probe-for-noninvasive-sentinel-lymph-node-mapping
#1
Mucong Li, Chengbo Liu, Xiaojing Gong, Rongqin Zheng, Yuanyuan Bai, Muyue Xing, Xuemin Du, Xiaoyang Liu, Jing Zeng, Riqiang Lin, Huichao Zhou, Shouju Wang, Guangming Lu, Wen Zhu, Chihua Fang, Liang Song
We developed a linear ultrasound array-based real-time photoacoustic imaging system with a compact coaxial excitation handheld photoacoustic imaging probe for guiding sentinel lymph node (SLN) needle biopsy. Compared with previous studies, our system and probe have the following advantages: (1) the imaging probe is quite compact and user-friendly; (2) laser illumination and ultrasonic detection are achieved coaxially, enabling high signal-to-noise ratio; and (3) GPU-based image reconstruction enables real-time imaging and displaying at a frame rate of 20 Hz...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29673774/clinical-features-and-prognosis-of-asian-patients-with-acral-lentiginous-melanoma-who-have-nodal-nevi-in-their-sentinel-lymph-node-biopsy-specimen
#2
Ho-Jin Kim, Jeong-Wan Seo, Mee-Sook Roh, Ji-Hyun Lee, Ki-Hoon Song
BACKGROUND: Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations. OBJECTIVE: To investigate the clinical characteristics and significance of NN in SLBs from ALM patients. METHODS: We retrospectively analyzed 84 patients with ALM who underwent SLB between June 2010 and July 2017...
April 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29673015/analysis-of-246-sentinel-lymph-node-biopsies-of-patients-with-clinical-primary-breast-cancer-by-application-of-carbon-nanoparticle-suspension
#3
Shi-Xin Yang, Wen-Song Wei, Qi-Hua Jiang, Yu-Feng Zhou, Wei Qu, Jian-Hong Tu, Qian-Wen Ou-Yang, Zhi-Bing Zhou, Hao-Long Ding, Chun-Wei Xie
AIM: This study aims to explore the accuracy, specificity and laws of axillary lymph node metastasis predicted by sentinel lymph node biopsy (SLNB) by comparing axillary lymph node status via SLNB and axillary lymph node dissection (ALND) with nanocarbon as the tracer. METHODS: Forty six patients were retrospectively analyzed. These patients underwent SLNB with nanocarbon as the tracer from March 2013 to April 2014. RESULTS: Two hundred and forty six patients of sentinel lymph node (SLN) were successfully detected...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29670364/-99m-tc-labeled-sodium-phytate-and-stannous-chloride-injection-accurately-detects-sentinel-lymph-node-in-axillary-of-early-stage-breast-cancer-a-randomized-controlled-study
#4
Suisheng Yang, Weiyu Bao, Xiaorong Bai, Chen Gao, Binming Zhang, Zhuanji Jiang
Aim: The aim of this study was to assess the sentinel lymph node (SLN) detection rate and accuracy of 99m Tc-labeled sodium phytate and stannous chloride (99m Tc-PHY) injection versus 99m Tc-labeled sulfur colloid (99m Tc-SC) injection in sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer. Methods: A total of 146 consecutive female patients with early stage breast cancer were recruited in this open-labeled, randomized, controlled study...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29668599/which-is-better-for-predicting-pelvic-lymph-node-metastases-in-patients-with-cervical-cancer-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-or-a-sentinel-node-biopsy-a-retrospective-observational-study
#5
Tomohito Tanaka, Shun Sasaki, Hiromitsu Tsuchihashi, Yoshito Terai, Kazuhiro Yamamoto, Takashi Yamada, Masahide Ohmichi
Systematic pelvic lymph node resection may not be needed for patients with cervical cancer, especially in the early stage, if the pre- or intraoperative diagnosis of lymph node status is correct. The aim of this study was to evaluate the diagnostic accuracy of pelvic lymph node metastasis for fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) and sentinel node biopsy (SNB) of cervical cancer patients.Forty-eight patients with cervical cancer were imaged with FDG PET/CT before radical hysterectomy and underwent an SNB followed by systematic pelvic lymph node dissection...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665799/the-great-debate-at-melanoma-bridge-napoli-december-2nd-2017
#6
Paolo A Ascierto, Corrado Caracò, Jeffrey E Gershenwald, Omid Hamid, Merrick Ross, Ryan J Sullivan, Igor Puzanov
As part of the 2017 Melanoma Bridge congress (November 30-December 2, 2017, Napoli, Italy), the great debate session featured counterpoint views from leading experts on three contemporary controversial clinical issues in the care of the melanoma patient. These were: (1) whether complete lymph node dissection should be routinely offered to all melanoma patients with sentinel lymph node-positive disease; (2) whether first-line treatment of BRAF-mutated melanoma should consist of BRAF-targeted therapy or immunotherapy with checkpoint inhibitors; and (3) whether combined or sequential administration of treatments should be the preferred option in the management of patients with advanced melanoma...
April 17, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29660597/risk-stratification-of-sentinel-node-positive-melanoma-patients-defines-surgical-management-and-adjuvant-therapy-treatment-considerations
#7
Daniëlle Verver, David van Klaveren, Alexander C J van Akkooi, Piotr Rutkowski, Barry W E M Powell, Caroline Robert, Alessandro Testori, Barbara L van Leeuwen, Astrid A M van der Veldt, Ulrich Keilholz, Alexander M M Eggermont, Cornelis Verhoef, Dirk J Grünhagen
BACKGROUND: In light of the evolving landscape of adjuvant therapy in melanoma and the recently confirmed absent survival benefit of completion lymph node dissection (CLND), it becomes important to explore possible consequences of omitting CLND, and whether it is possible to adequately stratify positive sentinel node (SN) patients solely based on information retrieved from the melanoma up to the sentinel lymph node biopsy (SLNB). METHODS: A retrospective cohort from nine European Organization for Research and Treatment of Cancer Melanoma Group centres was used...
April 13, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29660577/value-and-best-way-for-detection-of-sentinel-lymph-node-in-early-stage-endometrial-cancer-selective-lymphadenectomy-algorithm
#8
Ahmed Samy El-Agwany, Mahmoud Hanafy Meleis
INTRODUCTION: The cornerstone of treatment for endometrial carcinoma is total abdominal hysterectomy and bilateral salpingo-oophoprectomy. Pelvic lymphadenectomy, with or without para-aortic lymphadenectomy, plays an important role in the surgical staging of endometrial carcinoma, and provides more accurate prognostic information. AIMS: We aimed to evaluate the value and techniques for SLN mapping in early stage endometrial cancer with low risk for lymph node metastasis and whether selective or systematic lymphadenectomy is needed according to the results of proposed algorithm...
March 23, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29658338/chyle-leak-following-an-axillary-sentinel-lymph-node-biopsy-for-breast-cancer-in-a-patient-with-superior-vena-caval-thrombosis-a-case-report-and-review-of-the-literature
#9
Z Al-Ishaq, S Gupta, M A Collins, T Sircar
Chyle leak is a very rare complication following an axillary lymph node dissection. We report a case of chyle leak following sentinel lymph node biopsy in a patient with breast cancer with superior vena caval thrombosis. To our knowledge, this is the first case report of chyle leakage following axillary sentinel lymph node biopsy. We describe the aetiology, prevention and treatment strategy that can be adopted in these patients.
April 16, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29651855/surgical-treatment-of-melanoma
#10
K Novotná, M Arenbergerová, J Miletín, J Kníže, V Šandera, K Schwarzmannová, J Bayer, A Sukop
Malignant melanoma is a serious disease, the incidence of which rises. Since the most important treatment method is sufficient wide skin and subcutaneous tissue excision, plastic surgeon is often the only specialist who is able to close the resulting defect. This paper deals with recommendations and treatment options for malignant melanoma from the point of a plastic surgeon. The primary width of excised safety rim of healthy tissue with regards to the depth of melanoma invasion differs. Safety margin is 0...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29651594/prospective-study-of-shoulder-strength-shoulder-range-of-motion-and-lymphedema-in-breast-cancer-patients-from-pre-surgery-to-5-years-after-alnd-or-slnb
#11
Roser Belmonte, Monique Messaggi-Sartor, Montse Ferrer, Angels Pont, Ferran Escalada
OBJECTIVE: Determine the changes in shoulder strength, shoulder range of motion, and arm volume in breast cancer patients treated with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) METHOD: Sixty-eight SLNB and 44 ALND patients were followed up from pre-surgery to 5 years after surgery. Primary outcomes were the differences between affected and non-affected sides for the following: shoulder strength measured by dynamometry, shoulder range of motion measured by goniometry, and lymphedema measured by volume...
April 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29650917/-a-case-of-primary-spinddle-cell-carcinoma-of-the-breast
#12
Hiroshi Kawai, Chihiro Yoshikawa, Kento Kawasaki, Norichika Iga, Ryosuke Yoshida, Naohisa Waki, Futoshi Uno, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita, Shinichiro Miyoshi
A 76-year-old female underwent breast-conserving surgery of the right breast and sentinel lymph node biopsy for primary breast cancer. Three years later, mammography and ultrasonography showed a small nodule in the right breast. There was nothing abnormal in the left breast. Three months later, she complained of a huge and rapid growing mass in the left breast. Malignant cells were obtained on fine needle aspiration biopsy in the right breast tumor. But it was not possible to diagnose whether the left breast tumor was benign or malignant on fine needle aspiration biopsy and needle biopsy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650835/-diagnosis-of-a-non-invasive-ductal-carcinoma-assisted-by-long-term-follow-up-of-spontaneous-nipple-discharge-a-case-report
#13
Tomohiro Hirano, Shuhei Suzuki, Keita Adachi, Hitomi Kubota, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai
We report a case of a non-invasive ductal carcinoma revealed on long-term follow-up of spontaneous nipple discharge. The patient, a 36-year-old woman, had noticed spontaneous nipple discharge from both breasts over a 3-year period. Mammography and ultrasonography did not reveal any lesions in the breasts. The nipple discharge from her left breast stopped 36 months after initial clinical assessment. However, the nipple discharges from her right breast transformed into a bloody discharge from a single duct. Ultrasonography showed a tumor, 6mm in diameter, in the upper-outer quadrant of her right breast...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650221/lymph-node-dissection-in-patients-with-melanoma-and-sentinel-lymph-node-metastasis-an-updated-evidence-based-decision-algorithm
#14
D Moreno-Ramírez, A Boada, L Ferrándiz, E Samaniego, G Carretero, E Nagore, P Redondo, P Ortiz-Romero, J Malvehy, R Botella-Estrada
Recent publication of the results of clinical trials in which lymph node dissection was not associated with any survival benefit in patients with sentinel node metastasis makes it necessary to reconsider the treatment of patients with melanoma. This article provides an update on the available evidence on the diverse factors (routes of metastatic spread, predictors, adjuvant therapy, etc.) that must be considered when treating patients with sentinel node-positive melanoma. The authors propose a decision-making algorithm for use in this clinical setting...
April 9, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29649327/evaluation-of-intraoperative-touch-imprint-cytology-on-axillary-sentinel-lymph-nodes-in-invasive-breast-carcinomas-a-retrospective-study-of-1227-patients-comparing-sensitivity-in-the-different-tumor-subtypes
#15
Hafsteinn Ingi Pétursson, Anikó Kovács, Jan Mattsson, Roger Olofsson Bagge
BACKGROUND: Intraoperative evaluation of the axillary sentinel lymph node (SLN) in patients with breast carcinoma reduces the need of re-operations in cases where an axillary completion lymph node dissection (CLND) is indicated. Different methods have been used to determine the SLN status intraoperatively, e.g. frozen section histology (FS) and touch imprint cytology (TIC). The sensitivity of intraoperative TIC examination on SLN is not consistent between different studies and varies according to different tumor histologic subtypes, tumor size and the age of the patient...
2018: PloS One
https://www.readbyqxmd.com/read/29648676/sentinel-lymph-node-biopsy-in-cutaneous-squamous-cell-carcinoma-series-of-37-cases-and-systematic-review-of-the-literature
#16
Raphael Lhote, Jérôme Lambert, Jumie Lejeune, Jeremy Gottlieb, Antoine Badaoui, Maxime Battistella, Jennifer Roux, Cecile Pages, Laetitia Vercellino, Catherine Vilmer, Christine Le Maignan, Catherine Escande, Besma MBarek, Martine Bagot, Celeste Lebbé, Nicole Basset-Seguin
Cutaneous squamous cell carcinoma is one of the most common skin cancers and can lead to patient death. Early diagnosis of node metastasis is a major goal for dermatologists and oncologists. The sentinel lymph node procedure has been proposed to improve this issue but is still debated. To evaluate the efficacy and the impact of this technique on prognosis of cutaneous squamous cell carcinoma, 37 patients (Saint Louis Hospital, Paris - France) who underwent sentinel lymph node biopsy and 290 cases from the literature were analyzed...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29648671/effect-of-age-on-melanoma-risk-prognosis-and-treatment-response
#17
Simone Ribero, Luigia Stefania Stucci, Elena Marra, Riccardo Marconcini, Francesco Spagnolo, Laura Orgiano, Virginia Picasso, Paola Queirolo, Guiseppe Palmieri, Pietro Quaglino, Veronique Bataille
As for all types of cancer, the incidence of melanoma increases with age. However, naevus counts (the principal risk factor for melanoma) decrease with age; hence the relationship between ageing and melanoma is complex. Subjects who maintain a high naevus count after the age of 50 years are more likely to be affected by melanoma, as their lesions do not senesce. Longer telomere length, which is strongly related to age, is linked to high naevus counts/melanoma risk; thus melanoma biology is influenced by factors that slow down ageing...
April 12, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29629218/safety-of-laparoscopic-sentinel-basin-dissection-in-patients-with-gastric-cancer-an-analysis-from-the-senorita-prospective-multicenter-quality-control-trial
#18
Ji Yeong An, Jae Seok Min, Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang Uk Han, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Ji Yeon Park, Young Woo Kim, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu
Purpose: We investigated complications after laparoscopic sentinel basin dissection (SBD) for patients with gastric cancer who were enrolled in a quality control study, prior to the phase III trial of sentinel lymph node navigation surgery (SNNS). Materials and Methods: We analyzed prospective data from a Korean multicenter prerequisite quality control trial of laparoscopic SBD for gastric cancer and assessed procedure-related and surgical complications. All complications were classified according to the Clavien-Dindo Classification (CDC) system and were compared with the results of the previously published SNNS trial...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29623009/multifunctional-biomedical-imaging-in-physiological-and-pathological-conditions-using-a-nir-ii-probe
#19
Kangquan Shou, Chunrong Qu, Yao Sun, Hao Chen, Si Chen, Lei Zhang, Haibo Xu, Xuechuan Hong, Aixi Yu, Zhen Cheng
Compared with imaging in the visible (400 - 650 nm) and near-infrared window I (NIR-I, 650 - 900 nm) regions, imaging in near-infrared window II (NIR-II, 1,000-1,700 nm) is a highly promising in vivo imaging modality with improved resolution and deeper tissue penetration. In this work, a small molecule NIR-II dye,5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine), has been successfully encapsulated into phospholipid vesicles to prepare a probe CQS1000...
June 20, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29619546/clinical-application-of-photodynamic-medicine-technology-using-light-emitting-fluorescence-imaging-based-on-a-specialized-luminous-source
#20
REVIEW
Tsutomu Namikawa, Kazune Fujisawa, Eri Munekage, Jun Iwabu, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Michiya Kobayashi, Kazuhiro Hanazaki
The natural amino acid 5-aminolevulinic acid (ALA) is a protoporphyrin IX (PpIX) precursor and a new-generation photosensitive substance that accumulates specifically in cancer cells. When indocyanine green (ICG) is irradiated with near-infrared (NIR) light, it shifts to a higher energy state and emits infrared light with a longer wavelength than the irradiated NIR light. Photodynamic diagnosis (PDD) using ALA and ICG-based NIR fluorescence imaging has emerged as a new diagnostic technique. Specifically, in laparoscopic examinations for serosa-invading advanced gastric cancer, peritoneal metastases could be detected by ALA-PDD, but not by conventional visible-light imaging...
April 4, 2018: Medical Molecular Morphology
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