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https://www.readbyqxmd.com/read/29907432/sensitivity-and-specificity-of-sentinel-lymph-node-biopsy-in-patients-with-oral-squamous-cell-carcinomas-using-indocyanine-green-fluorescence-imaging
#1
Ahmed Al-Dam, Clarissa Precht, Armelle Barbe, Carsten Kohlmeier, Henning Hanken, Johannes Wikner, Gerhard Schön, Max Heiland, Alexandre T Assaf
PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer. PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection...
May 23, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29907233/indocyanine-green-fluorescence-imaging-with-lymphoscintigraphy-for-sentinel-node-biopsy-in-head-and-neck-melanoma
#2
Rebecca W Knackstedt, Rafael A Couto, Brian Gastman
BACKGROUND: Head and neck melanoma is associated with a high false negative (FN) sentinel lymph node biopsy (SLNB) rate. If techniques are developed that can decrease FN SLNBs, better prognostic information will be obtained, and it may be possible to improve overall survival as patients are assigned to the appropriate adjuvant management. Our group previously demonstrated that the combination of lymphoscintigraphy and indocyanine green (ICG) fluorescence-based technology was feasible for SLNB in primary melanoma...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29905036/feasibility-of-using-negative-ultrasonography-results-of-axillary-lymph-nodes-to-predict-sentinel-lymph-node-metastasis-in-breast-cancer-patients
#3
Xue Chen, Yingjian He, Jiwei Wang, Ling Huo, Zhaoqing Fan, Jinfeng Li, Yuntao Xie, Tianfeng Wang, Tao Ouyang
Knowledge of the pathology of axillary lymph nodes (ALN) in breast cancer patients is critical for determining their treatment. Ultrasound is the best noninvasive evaluation for the ALN status. However, the correlation between negative ultrasound results and the sentinel lymph nodes (SLN) pathology remains unknown. To test the hypothesis that negative ultrasound results of ALN predict the negative pathology results of SLN in breast cancer patients, we assessed the association between ALN ultrasonography-negative results and the SLN pathology in 3115 patients with breast cancer recruited between October 2010 and April 2016 from a single cancer center, prospective database...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29896279/trends-and-outcomes-of-sentinel-lymph-node-biopsy-in-early-stage-vulvar-squamous-cell-carcinoma-a-population-based-study
#4
Juan Zhou, Wen-Wen Zhang, Xue-Ting Chen, San-Gang Wu, Jia-Yuan Sun, Qiong-Hua Chen, Zhen-Yu He
Purpose: To compare trends and outcomes between lymphadenectomy and sentinel lymph node biopsy (SLNB) in node-negative early-stage vulvar squamous cell carcinoma (SCC) using a population-based cancer registry. Methods: Patients with vulvar SCC registered on the Surveillance, Epidemiology, and End Results program between 2003 and 2013 were identified. Statistical analysis was performed using Cox regression proportional hazards to calculate hazard ratio (HR) and 95% confidence interval (CI). A 1:1 propensity score matching (PSM) method was performed to minimize selection bias...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29890814/the-lymphatic-drainage-pattern-of-internal-mammary-sentinel-lymph-node-identified-by-small-particle-radiotracer-99mtc-dextran-40-in-breast
#5
Xiao-Shan Cao, Guo-Ren Yang, Bin-Bin Cong, Peng-Fei Qiu, Yong-Sheng Wang
Purpose: The purpose of this study was to detect the lymphatic drainage pattern of internal mammary area and verify the concept of internal mammary sentinel lymph node (IM-SLN) in breast. Materials and Methods: A small particle radiotracer (99mTc-Dextran 40) was prepared and tested. 99mTc-Dextran 40 was injected into intraparenchyma at the sound breast by a modified radiotracer injection technique. Subsequently, dynamic single-photon emission computed tomography (SPECT), computed tomography (CT), and SPECT/CT combination images were performed to identify the radioactive lymph vessels and internal mammary lymph nodes (IMLNs)...
June 11, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29890463/hpv-infection-and-breast-cancer-results-of-a-microarray-approach
#6
Andriana Kouloura, Electra Nicolaidou, Ioannis Misitzis, Euaggelia Panotopoulou, Vasilios Smyrniotis, Giovanni Corso, Paolo Veroneci, Nikolaos Arkadopoulos
OBJECTIVES: Human papilloma virus (HPV) has been implicated in several types of epithelial cancer. The role of HPV in breast carcinogenesis has been a matter of debate fueled by conflicting reports in recent years. The aim of this study is to identify the prevalence of breast and cervical HPV infection in cancer patients by using a modern microarray approach. MATERIALS AND METHODS: In the present prospective study, 201 breast cancer patients were included. For each patient a detailed medical history was taken and during the operation, under sterile conditions, samples were collected, from the tumour, the healthy adjacent breast tissue and any positive sentinel lymph nodes...
June 4, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29889752/three-lymphadenectomy-strategies-in-low-risk-endometrial-carcinoma-a-cost-effectiveness-analysis
#7
Rudy S Suidan, Charlotte C Sun, Scott B Cantor, Andrea Mariani, Pamela T Soliman, Shannon N Westin, Karen H Lu, Sharon H Giordano, Larissa A Meyer
OBJECTIVE: To evaluate the cost-utility of three lymphadenectomy strategies in the management of low-risk endometrial carcinoma. METHODS: A decision analysis model compared three lymphadenectomy strategies in women undergoing minimally invasive surgery for low-risk endometrial carcinoma: 1) routine lymphadenectomy in all patients, 2) selective lymphadenectomy based on intraoperative frozen section criteria, and 3) sentinel lymph node mapping. Costs and outcomes were obtained from published literature and Medicare reimbursement rates...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29889028/usefulness-of-18-f-fdg-pet-ct-in-cutaneous-melanoma-patients-with-negative-sentinel-lymph-nodes-and-high-clark-levels
#8
Özge Vural Topuz, Fatma Arzu Görtan, Zübeyde Rana Kaya Döner, Çetin Önsel, Haluk Burçak Sayman
OBJECTIVE: We investigated the utility of PET/CT in cutaneous melanoma (CM) patients with pathological negative sentinel lymph nodes (SLN), within the first year. METHODS: The results of PET/CTs and SLN biopsy (SLNB) in 65 patients (39 male and 26 female, mean age 53.8) with a PET/CT in the first postoperative year were evaluated. Within this cohort, the utility of early PET/CT imaging was assessed in patients with negative SLNB. McNemar test was used to compare PET/CT findings with SLNB results...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29887702/the-futility-of-systematic-lymphadenectomy-in-early-stage-low-grade-endometrial-cancer
#9
Nidhi Nayyar, Prerna Lakhwani, Ashish Goel, Pankaj Kr Pande, Kapil Kumar
Lymphadenectomy is considered an integral part of comprehensive surgical staging of endometrial cancer but debate on the value of lymphadenectomy continues in early-stage endometrial cancer. The aim of our study was to determine the number of node positive patients in clinically early-stage low-grade (G1-G2) endometrioid endometrial cancer. We retro-prospectively analyzed the medical records of 155 women with endometrial pathology coming to the BLK cancer center between January 2015 and December 2017 and studied 60 patients of FIGO grade 1-2 endometrioid endometrial cancer confined to the uterus to determine the nodal positivity...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29887483/lymph-node-evaluation-in-high-risk-early-stage-endometrial-cancer-a-multi-institutional-retrospective-analysis-comparing-the-sentinel-lymph-node-sln-algorithm-and-sln-with-selective-lymphadenectomy
#10
Alessandro Buda, Maria Luisa Gasparri, Andrea Puppo, Liliana Mereu, Elena De Ponti, Giampaolo Di Martino, Antonia Novelli, Saverio Tateo, Michael Muller, Fabio Landoni, Andrea Papadia
OBJECTIVE: The aim of this study was to determine the impact of the sentinel lymph node mapping algorithm (SLN-A) on the staging in high-risk endometrial cancer (EC) compared to SLN plus selective lymphadenectomy (S-LND). METHODS: We retrospectively analyzed the database from a multicenter collaboration that included women with high risk features who underwent primary surgical staging. RESULTS: One-hundred and seventy-one women were identified (171), 66 in the SLN-A and 105 in the S-LND group, respectively...
June 7, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29880292/efficacy-and-safety-of-abp-980-compared-with-reference-trastuzumab-in-women-with-her2-positive-early-breast-cancer-lilac-study-a-randomised-double-blind-phase-3-trial
#11
Gunter von Minckwitz, Marco Colleoni, Hans-Christian Kolberg, Serafin Morales, Patricia Santi, Zorica Tomasevic, Nan Zhang, Vladimir Hanes
BACKGROUND: ABP 980 (Amgen Inc, Thousand Oaks, CA, USA) is a biosimilar of trastuzumab, with analytical, functional, and pharmacokinetic similarities. We compared the clinical safety and efficacy of ABP 980 with that of trastuzumab in women with HER2-positive early breast cancer. METHODS: We did a randomised, multicentre, double-blind, active-controlled equivalence trial at 97 study centres in 20 countries, mainly in Europe and South America. Eligible women were aged 18 years or older, had histologically confirmed HER2-positive invasive early breast cancer, an Eastern Cooperative Oncology Group performance status score of 0 or 1, and were planning to have surgical resection of the breast tumour with sentinel or axillary lymph node dissection and neoadjuvant chemotherapy...
June 4, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29879027/primary-ovarian-small-cell-carcinoma-of-pulmonary-type-with-coexisting-endometrial-carcinoma-in-a-breast-cancer-patient-receiving-tamoxifen-a-case-report-and-literature-review
#12
Lei Yin, Jianning Li, Yunhai Wei, Dejian Ma, Yamei Sun, Yanlai Sun
RATIONALE: Small cell carcinoma of the ovary (SCCO) is a rare and aggressive extra-pulmonary variant of small cell tumors of uncertain histogenesis. The pathogenesis and optimal treatment of SCCO is unclear. We present a very rare case of a synchronous primary ovarian small cell carcinoma and endometrioid adenocarcinoma of the uterus in a patient after 2 years of tamoxifen treatment for breast cancer. This is the first such report in the English literature. PATIENT CONCERNS: A 46-year-old woman had a history of left breast cancer that was treated with a simple mastectomy and sentinel lymph node biopsy in 2013...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29878361/association-between-ki-67-expression-and-clinical-outcomes-among-patients-with-clinically-node-negative-thick-primary-melanoma-who-underwent-nodal-staging
#13
Eric M Robinson, Brooke E Rosenbaum, Yilong Zhang, Robert Rogers, Jeremy Tchack, Russell S Berman, Farbod Darvishian, Iman Osman, Richard L Shapiro, Yongzhao Shao, David Polsky
BACKGROUND: Patients with thick primary melanomas (≥4 mm) have highly variable survival outcomes. Cell proliferation marker Ki-67 has been identified as promising biomarker in thick melanoma but has not been evaluated since the wide spread adoption of sentinel lymph node biopsy. We revisit its prognostic relevance in the sentinel node era. METHODS: We studied patients with thick (≥4 mm) primary melanoma prospectively enrolled in a clinicopathological biospecimen database from 2002 to 2015, and evaluated the prognostic value of Ki-67 expression while controlling for features included in the existing staging criteria...
June 7, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29876618/can-integrated-18f-fdg-pet-mr-replace-sentinel-lymph-node-resection-in-malignant-melanoma
#14
Benedikt Michael Schaarschmidt, Johannes Grueneisen, Vanessa Stebner, Joachim Klode, Ingo Stoffels, Lale Umutlu, Dirk Schadendorf, Philipp Heusch, Gerald Antoch, Thorsten Dirk Pöppel
PURPOSE: To compare the sensitivity and specificity of 18F-fluordesoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), 18F-FDG PET/magnetic resonance (18F-FDG PET/MR) and 18F-FDG PET/MR including diffusion weighted imaging (DWI) in the detection of sentinel lymph node metastases in patients suffering from malignant melanoma. MATERIAL & METHODS: Fifty-two patients with malignant melanoma (female: n = 30, male: n = 22, mean age 50...
June 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29876188/a-systematic-review-of-surgical-management-of-melanoma-of-the-external-ear
#15
Justin D Sawyer, Morgan L Wilson, Michael W Neumeister
Background: Historically, external ear melanomas have been treated aggressively, due to early perceptions suggesting they had poor prognosis and aggressive biological behavior. More recent evidence has not supported these notions. Methods: We completed a complete review of the literature involving malignant melanoma of the external ear. We then completed a quantitative analysis on seventy-three cases from 8 reports that contained case-level data, assessing factors that influence recurrence, and assessing characteristics of the melanomas based on histological subtype...
April 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29872687/pregnancy-and-melanoma-recommendations-for-clinical-scenarios
#16
Juliana Berk-Krauss, Tracey N Liebman, Jennifer A Stein
Managing pregnant patients with a history of melanoma or with a melanoma diagnosis can be daunting and confusing for dermatologists. We present three clinical scenarios that raise questions about the safety of pregnancy in patients with a history of melanoma, skin biopsies during pregnancy, and excisions and sentinel lymph node biopsies during pregnancy. Our recommendations incorporate the most up-to-date clinical data to help guide clinicians when faced with pigmented lesions and melanoma in a pregnant patient...
June 2018: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29871010/diagnostic-and-prognostic-value-of-additional-spect-ct-in-sentinel-lymph-node-mapping-in-breast-cancer-patients
#17
Susanne Stanzel, Birgit Pernthaler, Thomas Schwarz, Vesna Bjelic-Radisic, Stefan Kerschbaumer, Reingard M Aigner
THE AIM: of the study was to demonstrate the diagnostic and prognostic value of SPECT/CT in sentinel lymph node mapping (SLNM) in patients with invasive breast cancer. METHODS: 114 patients with invasive breast cancer with clinically negative lymph nodes were included in this retrospective study as they were referred for SLNM with 99m Tc-nanocolloid. Planar image acquisition was accomplished in a one-day or two-day protocol depending on the schedule of the surgical procedure...
June 2018: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/29869773/extent-of-regional-lymph-node-surgery-and-impact-on-outcomes-in-patients-with-early-stage-breast-cancer-and-limited-axillary-disease-undergoing-mastectomy
#18
Omar Picado, Kristina Khazeni, Casey Allen, Danny Yakoub, Eli Avisar, Susan B Kesmodel
PURPOSE: Management of the axilla in patients with early-stage breast cancer (ESBC) has evolved. Recent trials support less extensive axillary surgery in patients undergoing mastectomy. We examine factors affecting regional lymph node (RLN) surgery and outcomes in patients with ESBC undergoing mastectomy. METHODS: Women with clinical T1/2 N0 M0 invasive BC who underwent mastectomy with 1-2 positive nodes were selected from the National Cancer Database (2004-2015)...
June 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29868979/multidisciplinary-management-of-the-axilla-in-patients-with-ct1-t2-n0-breast-cancer-undergoing-primary-mastectomy-results-from-a-prospective-single-institution-series
#19
Samantha Grossmith, Anvy Nguyen, Jiani Hu, Jennifer K Plichta, Faina Nakhlis, Linda Cutone, Laura Dominici, Mehra Golshan, Margaret Duggan, Katharine Carter, Esther Rhei, Thanh Barbie, Katherina Calvillo, Suniti Nimbkar, Jennifer Bellon, Julia Wong, Rinaa Punglia, William Barry, Tari A King
BACKGROUND: The after mapping of the axilla: radiotherapy or surgery (AMAROS) trial concluded that for patients with cT1-2 N0 breast cancer and one or two positive sentinel lymph nodes (SLNs), axillary radiotherapy (AxRT) provides equivalent locoregional control and a lower incidence of lymphedema compared with axillary lymph node dissection (ALND). The study prospectively assessed how often ALND could be replaced by AxRT in a consecutive cohort of patients undergoing mastectomy for cT1-2 N0 breast cancer...
June 4, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29868976/routine-axillary-ultrasound-for-patients-with-t1-t2-breast-cancer-does-not-increase-the-rate-of-axillary-lymph-node-dissection-based-on-predictive-modeling
#20
Jennifer Wellington, Thomas Sanders, Charles Mylander, Ashley Alden, Christine Harris, Robert Buras, Lorraine Tafra, Wen Liang, Lacey Stelle, Martin Rosman, Rubie Sue Jackson
BACKGROUND: Since publication of the American College of Surgeons Oncology Group Z0011 trial results, demonstrating that many patients with nonpalpable axillary lymph nodes and one or two positive sentinel nodes do not require axillary lymph node dissection (ALND), preoperative axillary ultrasound (AUS) has become controversial. Clinicians are concerned that AUS may lead to unnecessary ALND. The authors developed an algorithm (Algorithm 1) in which the number of AUS-suspicious nodes and tumor biology direct management...
June 4, 2018: Annals of Surgical Oncology
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