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https://www.readbyqxmd.com/read/29052960/treatment-and-outcomes-of-melanoma-in-asia-results-from-the-national-cancer-centre-singapore
#1
Yi Lin Teh, Wei Lin Goh, Sze Huey Tan, Grace Yong, Alisa Noor Hidayah Sairi, Khee Chee Soo, Johnny Ong, Claramae Chia, Grace Tan, Henry Soeharno, Mann Hong Tan, Michelle Chan, Selvarajan Sathiyamoorthy, Kesavan Sittampalam, Jonathan Teh, Francis Chin, Vijay Sethi, Melissa Teo, Richard Quek, Mohamad Farid
BACKGROUND: Acral melanoma (AM) and mucosal melanoma (MM) make up more than half of melanomas in Asia but comprise only 5% of cases in Caucasians, where cutaneous melanoma (CM) predominates. AM and MM are thought to be genetically and biologically distinct from CM. We report the characteristics and outcomes of melanoma patients from the National Cancer Centre Singapore. METHODS: Case records of 210 patients treated between 2002 and 2014 were reviewed. RESULTS: Median follow-up was 2...
October 20, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29051403/axillary-treatment-of-patients-with-breast-cancer-and-micrometastatic-disease-in-the-sentinel-lymph-node-our-experience
#2
Andrea Morlino, Giuseppe La Torre, Giuseppe Patitucci, Aldo Cammarota
AIM: Since the introduction of the sentinel lymph node biopsy (SLNB) in patients with breast cancer, micrometastases are detected frequently in the sln. PATIENTS AND METHODS: Between July 2005 and June 2016, 1244 patients were submitted to surgery for breast cancer. 431 patients cT1-2 N0 underwent to sentinel lymph node (SLN) and micrometastases were found in 68 of 431 screen-detected patients. Nearly all patients with both micro and macrometastases had axillary lymph node dissection (ALND)...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29047418/primary-small-cell-carcinoma-of-the-breast-a-case-report
#3
Iman Abou Dalle, Jaber Abbas, Fouad Boulos, Ziad Salem, Hazem I Assi
BACKGROUND: Neuroendocrine breast cancer is a rare entity that was defined in 2003 by the World Health Organization as a separate breast cancer subtype. The diagnosis of neuroendocrine breast cancer requires the presence of neuroendocrine features in at least 50% of malignant cells, the exclusion of non-mammary primary tumors, as well as the presence of an in situ component in breast histology. The treatment and prognosis of neuroendocrine breast cancer are still not well established...
October 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29037421/discussion-of-the-success-of-sentinel-lymph-node-biopsy-after-neoadjuvant-therapy-a-single-institution-review
#4
Barbara Pockaj
No abstract text is available yet for this article.
September 30, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29035756/lymph-node-wire-localization-post-chemotherapy-towards-improving-the-false-negative-sentinel-lymph-node-biopsy-rate-in-breast-cancer-patients
#5
Brittany Z Dashevsky, Ashley Altman, Hiroyuki Abe, Nora Jaskowiak, Jean Bao, David V Schacht, Deepa Sheth, Kirti Kulkarni
PURPOSE: To evaluate whether the disease status of the pre-neoadjuvant chemotherapy (NAC) core biopsied lymph node (preNACBxLN) in patients with node positive breast cancer corresponds to nodal status of all surgically retrieved lymph nodes (LNs) post-NAC and whether wire localization of this LN is feasible. MATERIALS AND METHODS: HIPPA compliant IRB approved retrospective study including breast cancer patients (a.) with preNACBxLN confirmed metastases, (b.) who received NAC, and (c...
October 7, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29033813/recurrence-of-melanoma-after-starting-apremilast-for-psoriasis
#6
Thomas G Salopek
This is a report on a 32-year-old man with a history of two previous melanomas with concurrent plaque-type psoriasis. His history dates to 2009, when he was diagnosed with his first melanoma on the right occiput, Clark's level IV, tumor thickness 1.53 mm, nonulcerated, mitotic index 1/mm(2). He subsequently developed nodal recurrence after an initial negative sentinel lymph node biopsy and was treated with complete lymph node dissection. In 2012, he was diagnosed with a second primary melanoma on the right upper chest, Clark's level IV, tumor thickness 0...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033071/secondary-node-analysis-as-an-indicator-for-axillary-lymphadenectomy-in-breast-cancer-patients
#7
Manel Cremades, Mireia Torres, Montse Solà, Jordi Navinés, Icíar Pascual, Antonio Mariscal, Albert Caballero, Eva Castellà, Miguel Ángel Luna, Joan Francesc Julián
INTRODUCTION: Currently, there is no agreement regarding if it would be necessary to perform an axillary lymph node dissection (ALND) in patients who have macrometastases in the sentinel lymph node (SLN). We studied the utility of the secondary node analysis (SN), defined as the following node after the SLN in an anatomical and lymphatic pathway, as a sign of malignant axillary involvement. METHODS: An observational, retrospective and multicentre study was designed to assess the utility of the SN as a sign of axillary involvement...
October 12, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29033068/axillary-treatment-in-breast-cancer-surgery-systematic-review-of-its-impact-on-survival
#8
Alejandra García Novoa, Benigno Acea Nebril
Sentinel lymph node biopsy and ACOSOG-Z0011 criteria have modified axillary treatment in breast cancer surgery. We performed a systematic review of studies assessing the impact of axillary treatment on survival. The search showed 6891 potentially eligible items. Of them, 23 clinical trials and 12 meta-analyses published between 1980 and 2017 met the study criteria. The review revealed that axillary lymph node dissection (ALND) can be omitted in patients pN0 and pN1mic, without compromising survival. In patients pN1 it is proposed not to treat the axilla or replace ALND for axillary radiotherapy...
October 12, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29032824/the-impact-on-survival-of-two-different-staging-strategies-in-apparent-early-stage-endometrial-cancer-comparing-sentinel-lymph-nodes-mapping-algorithm-and-selective-lymphadenectomy-an-italian-retrospective-analysis-of-two-reference-centers
#9
Alessandro Buda, Giampaolo Di Martino, Stefano Restaino, Elena De Ponti, Giorgia Monterossi, Daniela Giuliani, Alfredo Ercoli, Federica Dell'Orto, Giorgia Dinoi, Tommaso Grassi, Giovanni Scambia, Francesco Fanfani
OBJECTIVE: The role of lymphadenectomy in endometrial cancer is still uncertain. We aimed to evaluate the survival outcomes of two different strategies in apparent uterine confined disease by comparing sentinel lymph node (SLN) mapping and selective lymphadenectomy (LD). METHODS: We retrospectively reviewed women with preoperative stage I endometrial cancer underwent surgical staging with either SLN mapping, or LD in two Italian centers. RESULTS: Eight hundred and two women underwent surgical staging for preoperative stage I endometrial cancer were revised (145 Monza; 657 Rome)...
October 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29032256/real-time-fluorescent-sentinel-lymph-node-mapping-with-icg-in-women-with-previous-conization-undergoing-laparoscopic-surgery-for-early-invasive-cervical-cancer-comparison-with-radiotracer-blue-dye
#10
Alessandro Buda, Andrea Papadia, Giampaolo Di Martino, Sara Imboden, Beatrice Bussi, Luca Guerra, Elena De Ponti, Claudio Reato, Maria Luisa Gasparri, Cinzia Crivellaro, Michael Mueller
STUDY OBJECTIVE: To evaluate the added value of fluorescence dye Indocyanine Green (ICG) for sentinel lymph node (SLN) mapping in women with cervical cancer who had undergone previous conization (stage 1A-1B1), by comparing ICG versus Tc99(m) radiotracer + blue-dye (BD). DESIGN: A retrospective study by two European centers (San Gerardo Hospital, Italy and University of Berne, Switzerland). CANADIAN TASK FORCE FOR CLASSIFICATION OF THE STUDY DESIGN: II - 2 SETTING: Two academic medical centers...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29031423/the-state-of-surgical-axillary-management-and-adjuvant-radiotherapy-for-early-stage-invasive-breast-cancer-in-the-modern-era
#11
Justin M Mann, Xian Wu, Paul Christos, Himanshu Nagar
BACKGROUND: For clinical T1-2N0 breast cancer, sentinel lymph node biopsy (SLNB) has been shown in American College of Surgeons Oncology Group (ACOSOG) Z0011 to be sufficient for women with 1 to 2 positive sentinel lymph nodes with no added benefit for completion axillary lymph node dissection (ALND). Z0011 specified whole breast radiotherapy (RT) using standard tangential fields; however, later analysis showed variation in field design. We assessed nationwide practice patterns and examined factors associated with patients undergoing completion ALND and subsequent radiation field design...
September 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29030106/the-shift-from-sentinel-lymph-node-biopsy-performed-either-before-or-after-neoadjuvant-systemic-therapy-in-the-clinical-negative-nodes-of-breast-cancer-patients-results-and-the-advantages-and-disadvantages-of-both-procedures
#12
Sergi Fernandez-Gonzalez, Catalina Falo, Maria Jesus Pla, Sonia Pernas, Maite Bajen, Teresa Soler, Raul Ortega, Cecilia Quetglas, Xavier Perez-Martin, Maria Eulalia Fernandez Montoli, Miriam Campos, Mar Varela-Rodriguez, Jordi Ponce, Amparo Garcia-Tejedor
BACKGROUND: In patients with breast cancer who are candidates for neoadjuvant therapy (NAT), the timing of when to perform sentinel lymph node biopsy (SLNB) remains under discussion. The aim of this study was to compare the advantages and disadvantages of SLNB performed before and after NAT. PATIENTS AND METHODS: One hundred seventy-two patients, T1c to T3 and N0 (clinically and according to ultrasound) candidates for NAT were included. We compared the outcomes of 2 groups: (1) 122 patients of whom SLNB was performed before NAT (pre-NAT) from December 2006 to April 2014; and (2) 50 patients with SLNB performed after NAT (post-NAT) from May 2014 to July 2016...
September 4, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29029002/infrared-intraoperative-fluorescence-imaging-using-indocyanine-green-in-thoracic-surgery
#13
Olugbenga T Okusanya, Nicholas R Hess, James D Luketich, Inderpal S Sarkaria
Thoracic surgery faces many unique challenges that require innovative solutions. The increase in utilization of minimally invasive practices, poor overall cancer survival and significant morbidity of key operations remain key obstacles to overcome. Intraoperative fluorescence imaging is a process by which fluorescent dyes and imaging systems are used as adjuncts for surgeons in the operating room. Other surgical subspecialists have shown that intraoperative fluorescence imaging can be applied as a practical adjunct to their practices...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29028122/atypical-alk-positive-spitz-tumors-with-9p21-homozygous-deletion-report-of-two-cases-and-review-of-the-literature
#14
Andrew J Rand, Wendy L Flejter, Christopher A Dowling, Linda M Brooke, Genevieve M Boland, Daniela Kroshinsky, Isaac R Rosenblum, Marier Hernandez-Perez, Julie D R Reimann
ALK rearrangements occur in up to 10% of spitzoid melanocytic neoplasms. No reported cases have shown homozygous deletion of 9p21 (CDKN2A) or gains of 6p25 (RREB1) or 11q13 (CCND1), which have been associated with aggressive clinical behavior. Here we report two unique cases. Case 1 occurred in a 9-year-old male with a 14-mm nodule on the anterior left thigh. Biopsy revealed an ALK-positive Spitz tumor containing an irregular nodule of densely packed melanocytes with increased mitoses and loss of p16 immunoreactivity...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29024796/comparative-analysis-of-clinics-pathologies-and-immune-responses-in-balb-c-and-c57bl-6j-mice-infected-with-streptobacillus-moniliformis
#15
Juliane Fornefett, Jaqueline Krause, Kristin Klose, Felix Fingas, Rayk Hassert, Tobias Eisenberg, Wieland Schrödl, Thomas Grunwald, Uwe Müller, Christoph G Baums
Streptobacillus (S.) moniliformis is a rat-associated zoonotic pathogen that occasionally causes disease in other species. We investigated the working hypothesis that intranasal infection might lead to different immune responses in C57BL/6 and BALB/c mice associated with distinct pathologies. This study confirmed with 75% mortality the known high susceptibility of C57BL/6 mice to Streptobacillus moniliformis infection in comparison to BALB/c mice which did not develop signs of disease. Main pathologies in C57BL/6 mice were purulent to necrotizing lymphadenitis and pneumonia...
October 10, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29024241/sentinel-node-biopsy-in-ductal-carcinoma-in-situ-of-the-breast-never-justified
#16
Luca Sorrentino, Alessandra Sartani, Daniela Bossi, Rosella Amadori, Manuela Nebuloni, Marta Truffi, Matteo Bonzini, Eliana Riggio, Diego Foschi, Fabio Corsi
Sentinel lymph node biopsy for ductal carcinoma in situ (DCIS) of the breast is not standard of care. However, nodal involvement for DCIS patients is reported. Aim of our study was to identify preoperative features predictive of nodal involvement in DCIS patients. We have retrospectively reviewed 175 patients with a preoperative diagnosis of DCIS following a vacuum-assisted breast biopsy, and undergoing surgery with sentinel node biopsy. Variables distribution was compared between patients upstaged to invasive cancer at final pathology and patients with a confirmed DCIS, and between positive vs negative sentinel node patients...
October 11, 2017: Breast Journal
https://www.readbyqxmd.com/read/29019543/predictive-factors-of-axillary-metastasis-in-patients-with-breast-cancer-and-positive-sentinel-lymph-node-biopsy
#17
Olívio Feitosa Costa, Rafael Bustamante Castro, Cibele Vasconcelos Oliveira, Thais Vieira Nogueira Feitosa, Josualdo Justino Alves, Francisco Pimentel Cavalcante, Marcos Venício Alves Lima
OBJECTIVE: to evaluate the risk factors for the presence of non-sentinel axillary metastatic disease in patients with breast cancer and positive sentinel node biopsy. Methods: retrospective cross-sectional study of women with breast cancer operated at the Cancer Institute of Ceará between 2002 and 2012 and submitted to sentinel lymph node biopsy. RESULTS: Among 946 breast cancer patients, 331 underwent sentinel lymph node biopsy, which was positive in 83. These patients underwent axillary lymphadenectomy and 39 (46%) had metastases in other axillary lymph nodes...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29016707/minimal-clinical-impact-of-intraoperative-examination-of-sentinel-lymph-nodes-in-patients-with-ductal-carcinoma-in-situ-an-opportunity-for-improved-resource-utilization
#18
Eugene T Shin, Amy S Joehlin-Price, Doreen M Agnese, Debra L Zynger
Objectives: There is little information regarding sentinel lymph node (SLN) frozen-section examination in patients with a history of ductal carcinoma in situ (DCIS). We evaluated the usage, clinical impact, and pathology resources used for SLN cryosectioning in mastectomy cases with a DCIS history. Methods: Mastectomies with SLNs submitted from 2012 to 2013 at a tertiary care center were analyzed. Medicare reimbursement was used to estimate pathology health care expenditures of intraoperative frozen sections...
September 18, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28991362/axillary-tumour-burden-in-women-with-a-fine-needle-aspiration-core-biopsy-proven-positive-node-on-ultrasonography-compared-to-women-with-a-positive-sentinel-node
#19
P Lloyd, E Theophilidou, R G Newcombe, L Pugh, A Goyal
BACKGROUND: The sensitivity of axillary ultrasonography (AUS) has increased in recent years, enabling detection of even low-volume axillary nodal metastases. The aim here was to evaluate the axillary tumour burden in women with a fine-needle aspiration/core biopsy-proven positive node on AUS and in those with a positive sentinel node biopsy (SNB). METHODS: This retrospective cohort study included all patients with early breast cancer who had AUS and axillary lymph node dissection (ALND) between 2011 and 2014...
October 9, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28990127/patterns-of-axillary-evaluation-in-older-patients-with-breast-cancer-and-associations-with-adjuvant-therapy-receipt
#20
Laura S Dominici, Helmneh M Sineshaw, Ahmedin Jemal, Chun Chieh Lin, Tari A King, Rachel A Freedman
PURPOSE: Although axillary lymph node status has traditionally been a key factor in informing adjuvant breast cancer therapy recommendations, this information may be less relevant as our focus shifts more towards tumor biology, particularly in older patients where comorbidity influences treatment decisions and nodal staging and/or surgery may not improve outcomes. We examined patterns of axillary surgery and associations between axillary surgery and receipt of adjuvant treatment in older breast cancer patients...
October 9, 2017: Breast Cancer Research and Treatment
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