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https://www.readbyqxmd.com/read/29232171/sentinel-lymph-node-biopsy-and-management-of-regional-lymph-nodes-in-melanoma-american-society-of-clinical-oncology-and-society-of-surgical-oncology-clinical-practice-guideline-update
#1
Sandra L Wong, Mark B Faries, Erin B Kennedy, Sanjiv S Agarwala, Timothy J Akhurst, Charlotte Ariyan, Charles M Balch, Barry S Berman, Alistair Cochran, Keith A Delman, Mark Gorman, John M Kirkwood, Marc D Moncrieff, Jonathan S Zager, Gary H Lyman
Purpose To update the American Society of Clinical Oncology (ASCO)-Society of Surgical Oncology (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma. Methods An ASCO-SSO panel was formed, and a systematic review of the literature was conducted regarding SLN biopsy and completion lymph node dissection (CLND) after a positive sentinel node in patients with melanoma. Results Nine new observational studies, two systematic reviews, and an updated randomized controlled trial of SLN biopsy, as well as two randomized controlled trials of CLND after positive SLN biopsy, were included...
December 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29232158/sentinel-lymph-node-biopsy-and-management-of-regional-lymph-nodes-in-melanoma-american-society-of-clinical-oncology-and-society-of-surgical-oncology-clinical-practice-guideline-update-summary
#2
Sandra L Wong, Erin B Kennedy, Gary H Lyman
No abstract text is available yet for this article.
December 12, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29228459/axillary-reverse-mapping-with-indocyanine-green-or-isosulfan-blue-demonstrate-similar-crossover-rates-to-radiotracer-identified-sentinel-nodes
#3
Deshka Foster, Nicole Choy, Catherine Porter, Shushmita Ahmed, Irene Wapnir
BACKGROUND: Sentinel lymph node (SLN) resection is imperative for breast cancer staging. Axillary reverse mapping (ARM) can preserve arm draining nodes and lymphatics during surgery. ARM is generally performed with isosulfan blue (ISB), restricting its use for concurrent SLN biopsy. Indocyanine green (ICG) could serve as an alternative to ISB for ARM procedures. METHODS: SLN mapping and biopsy was performed via periareolar injection of 99 technetium-sulfur colloid (99m TcSc, TSC)...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29227250/oncoplastic-surgery-of-multicentric-multifocal-breast-cancer-case-report
#4
I Kokhreidze
The multicentric/multifocal form of breast cancer has been considered as relative contraindicationfor breast conserving surgery. According to the results of the studies conducted in the last century, the local recurrence rate of the disease after breast conserving surgeries of multicentric/multifocal breast cancer exceeds 40%. Thus these data were considered as main argument for mastectomy advocates, as non-alternative surgical treatment in these cases. Wide clinical application of oncoplastic surgical techniques gave us possibilities to resolve dilemma: excise tumor - containing quadrant with achieving clear margins and satisfactory cosmetic outcome, without increasing risk of disease-related complications...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29225690/do-we-need-regional-guidelines-for-breast-cancer-management-in-the-mena-region-mena-breast-cancer-guidelines-project
#5
Reham Fayed, Dina Hamza, Heba Abdallah, Mohamed Kelany, Amira Tahseen, Adel T Aref
Purpose: Breast cancer is the most common cancer among females worldwide in general and in the Middle East and the North African region (MENA region) in particular. Management of breast cancer in the MENA region faces a lot of challenges, which include younger age at presentation, aggressive behaviour, lack of national breast screening programmes and lack of reliable data registries as well as socioeconomic factors. These factors make applying the international guidelines for breast cancer management very challenging...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29223564/indocyanine-green-assisted-parametrial-dissection-during-type-c1-radical-hysterectomy-after-sentinel-lymph-node-biopsy-in-early-stage-cervical-cancer
#6
Nicolò Bizzarri, Valentina Ghirardi, Ali Kucukmetin
OBJECTIVES: The standard treatment for FIGO stage 1B1 cervical cancer is radical hysterectomy (RH) [1]. Indocyanine-green (ICG) is a drug injected within the cervical stroma to detect the sentinel lymph node (SLN) in cervical cancer [2,3]. ICG travels through the lymphatic channels in the lateral parametrium, which results enhanced with green, before reaching the SLNs. This could help identifying the surgical landmarks. The aim of this video is to propose a new approach to perform parametrial dissection as part of RH under the guidance of ICG...
December 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29218428/spect-ct-looking-beyond-sentinel-lymph-node-identification-for-improving-patient-outcomes
#7
EDITORIAL
Robert Sibley, Rathan M Subramaniam
No abstract text is available yet for this article.
December 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29217399/feasibility-of-breast-mri-after-sentinel-procedure-for-breast-cancer-with-superparamagnetic-tracers
#8
Benedict Krischer, Serafino Forte, Tilo Niemann, Rahel A Kubik-Huch, Cornelia Leo
RATIONALE: The gold standard for detection of axillary sentinel lymph nodes uses injection of a radioisotope (99Tc Nanocoll). As an alternative to this method, a magnetometer detecting the superparamagnetic tracer Sienna+® can be applied for detection of sentinel lymph nodes. The goal of this study was to determine whether interpretation of breast MRI is impaired by Sienna+® tracer residues in the operated breast and axillary lymph nodes after a sentinel procedure using this tracer...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29217356/improved-stratification-of-pt1-melanoma-according-to-the-8th-american-joint-committee-on-cancer-staging-edition-criteria-a-dutch-population-based-study
#9
D Verver, W J Louwman, S Koljenović, C Verhoef, D J Grünhagen, A C J van Akkooi
INTRODUCTION: The 8th American Joint Committee on Cancer (AJCC) staging edition includes revisions regarding pT1 melanomas. We aimed to evaluate the expected impact of this edition on staging and survival in the Dutch pT1 melanoma population. METHODS: In total, 32,935 pT1 melanoma patients, whose data were retrieved from the Netherlands Cancer Registry between 2003 and 2015, were included in the study. Patients were stratified by the 6th AJCC edition (cohort 1: 2003-2009) and 7th edition (cohort 2: 2010-2015) and all reclassified according to the 8th edition...
December 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29214646/endoscopic-sentinel-lymph-node-biopsy-using-indocyanine-green-neomannosyl-human-serum-albumin
#10
Young Min Park, Yu Hua Quan, Ki Hyeok Kwon, Jae-Gu Cho, Jeong-Soo Woo, Beop-Min Kim, Yun-Sang Lee, Jae Min Jeong, Hyun Koo Kim, Jae-Jun Song
OBJECTIVE: The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green-neomannosyl human serum albumin (ICG:MSA) and a custom-made intraoperative color-and-fluorescence-merged imaging system (ICFIS). METHODS: Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom imaging system equipped with an endoscope. RESULTS: ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n = 3, IGC:MSA n = 3)...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29213225/role-of-blue-dye-for-sentinel-lymph-node-detection-in-early-endometrial-cancer
#11
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani
Background: Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye's cervical injection is a valid and "low-cost" method to obtain mapping of lymphatic drainage in patient with early endometrial cancer...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29209873/99mtc-rituximab-as-a-tracer-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-a-single-center-analysis
#12
Jiwei Wang, Tie Fan, Yingjian He, Xue Chen, Zhaoqing Fan, Yuntao Xie, Tianfeng Wang, Jinfeng Li, Tao Ouyang
PURPOSE: This study aimed to determine the long-term prognosis of breast cancer patients with 99mTc-rituximab for sentinel lymph node biopsy (SLNB). METHODS: A total of 2947 patients with negative sentinel lymph nodes (SLNs) omitting axillary lymph node dissection (ALND), treated between June 2005 and December 2013, were retrospectively analyzed. SLNB was performed prior to adjuvant therapy. RESULTS: After a median follow-up of 62 months, 22 cases of axillary recurrence (AR) were observed...
December 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29209551/synchronous-occurrence-of-primary-breast-carcinoma-and-primary-colon-adenocarcinoma
#13
Gurkan Yetkin, Fevzi Celayir, Ismail Ethem Akgun, Ramazan Ucak
A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29205451/subdermal-ultrasound-contrast-agent-injection-for-sentinel-lymph-node-identification-an-analysis-of-safety-and-contrast-agent-dose-in-healthy-volunteers
#14
Priscilla Machado, Maria Stanczak, Ji-Bin Liu, Jason N Moore, John R Eisenbrey, Laurence Needleman, Walter K Kraft, Flemming Forsberg
OBJECTIVES: Mapping of the lymphatic chain for identification of the sentinel lymph node (SLN) is an important aspect of predicting outcomes for patients with breast cancer, and it is usually performed as an intraoperative procedure using blue dye and/or radiopharmaceutical agents. Recently, the use of contrast-enhanced ultrasound (CEUS) has been proposed as an alternative imaging technique for this mapping. The objective of this study was to evaluate the use of subdermal administration of the ultrasound (US) contrast agent Sonazoid (GE Healthcare, Oslo, Norway) in terms of patient safety and to select the dose to be used for lymphatic applications in humans...
December 5, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29204531/axillary-lymph-node-coverage-with-3-dimensional-tangential-field-irradiation-and-correlation-with-heart-and-lung-dose
#15
Geraldine Jacobson, Nicole Bunda-Randall, Sijin Wen, Matthew Miller
Purpose: The American College of Surgeons Oncology Group Z0011 trial indicated no benefit from axillary lymph node (LN) dissection after a positive sentinel LN biopsy in patients receiving breast irradiation, suggesting that level I-II LNs were covered in tangential fields. Methods and materials: We evaluated 50 computed tomography-based tangential breast plans and contoured level I-III axillary LNs using the Radiation Therapy Oncology Group guidelines. The volumes of level I-III LN regions covered by 90% and 95% of the prescription dose (PD) were calculated and correlated with the V20 ipsilateral lung and mean heart dose...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29201278/axillary-nodal-staging-with-contrast-enhanced-ultrasound
#16
REVIEW
Nisha Sharma, Karina Cox
Purpose of Review: Axillary staging in the context of breast cancer is a contentious topic due to the varied practices across UK, Europe, and America. The ACOSOG Z0011 trial has questioned the role of axillary ultrasound in women with breast cancer. Published data has shown that women with ultrasound-positive lymph nodes have a worse prognosis than those with ultrasound-negative lymph nodes. Axillary ultrasound is limited as the sentinel lymph node (SLN) cannot be identified using B-mode ultrasound; however, with the advent of contrast-enhanced ultrasound (CEUS), this has now changed...
2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/29198586/metastases-of-malignant-neoplasms-historical-biological-clinical-considerations
#17
REVIEW
Mark R Wick
The metastasis of neoplastic cells from their site of origin to distant anatomic locations continues to be the principal cause of death from malignant tumors, and that fact has been recognized by physicians for over a century. After the work done by Halsted in the treatment of breast cancer in the 1880s, accepted surgical canon held that metastasis occurred in a linear fashion, with centrifugal "growth in continuity" from the primary neoplasm that first involved regional lymph nodes. Those structures were considered to then be the sources of more distant, visceral metastases...
November 24, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29197044/intraoperative-ultrasound-guided-excision-of-axillary-clip-in-patients-with-node-positive-breast-cancer-treated-with-neoadjuvant-therapy-ilina-trial-a-new-tool-to-guide-the-excision-of-the-clipped-node-after-neoadjuvant-treatment
#18
Christian Siso, Juan de Torres, Antonio Esgueva-Colmenarejo, Martin Espinosa-Bravo, Neus Rus, Octavi Cordoba, Roberto Rodriguez, Vicente Peg, Isabel T Rubio
BACKGROUND: The accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant therapy (NAT) has been improved with the placement of a clip in the positive node prior to treatment. Several methods have been described for clipped node excision during SLNB after NAT. We assessed the feasibility of intraoperative ultrasound (IOUS)-guided excision of the clipped node during SLNB and investigated whether the accuracy of SLNB is improved. METHODS: After approval by the Institutional Ethics Committee, all breast cancer patients undergoing NAT had an US-visible clip placed in the positive node...
December 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29196097/the-influence-of-tumour-derived-extracellular-vesicles-on-local-and-distal-metastatic-dissemination
#19
REVIEW
Laura Nogués, Alberto Benito-Martin, Marta Hergueta-Redondo, Héctor Peinado
Extracellular vesicles (EVs) are key mediators of intercellular communication that have been ignored for decades. Tumour cells benefit from the secretion of vesicles as they can influence the behaviour of neighbouring tumour cells within the tumour microenvironment. Several studies have shown that extracellular vesicles play an active role in pre-metastatic niche formation and importantly, they are involved in the metastatic organotropism of different tumour types. Tumour-derived EVs carry and transfer molecules to recipient cells, modifying their behaviour through a process known as "EV-driven education"...
November 28, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29194989/contralateral-neck-metastases-in-lateralised-resectable-advanced-stage-oropharyngeal-squamous-cell-carcinoma-results-of-57-patients-undergoing-bilateral-selective-neck-dissection
#20
Hannah Rosalie Fox, Andrew Robson, Helen Cocks, David Meikle, Charles Kelly, Rebecca Goranova, Josef Kovarik, Ghazia Shaikh, Vinidh Paleri, James O'Hara
This series demonstrates unique data assessing the surgical staging of the cN0 contralateral neck in lateralised oropharyngeal squamous cell carcinoma. Only 5 out of 57 patients were found to have occult nodal metastases. The rate appears higher in HPV negative disease (3/5 patients) than HPV positive patients (2/52 patients) This multi-departmental policy in the management of resectable oropharyngeal squamous cell carcinoma led to the reduction of adjuvant radiotherapy field in 52 patients, and appropriate intensification of adjuvant therapy in 5 patients...
December 1, 2017: Clinical Otolaryngology
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