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https://www.readbyqxmd.com/read/28629570/the-association-between-multiple-sclerosis-and-spondylosis-when-and-why
#1
Vasileios G Xydis, Anastasia K Zikou, Vassiliki Kostadima, Loukas G Astrakas, Paraskevi Kosta, Maria I Argyropoulou
OBJECTIVES: To evaluate risk factors for the development of cervical spine spondylosis (CSS) in patients with multiple sclerosis (MS) and to propose a pathogenetic mechanism. METHODS: Forty-two consecutive patients aged 23-66 years with MS and 42 age and sex matched controls were evaluated retrospectively; Clinical disability was evaluated with the expanded disability status scale (EDSS) and spasticity with the Asworth score. Total brain lesion volume (BLV), total grey matter (GM) volume and deep GM volume were assessed...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622016/endoplasmic-reticulum-stress-is-involved-in-nucleus-pulposus-degeneration-and-attenuates-low-ph-induced-apoptosis-of-rat-nucleus-pulposus-cells
#2
Zhi-Yang Xie, Lu Chen, Feng Wang, Lei Liu, Cong Zhang, Kun Wang, Feng Cai, Arjun Sinkemanni, Xin Hong, Xiao-Tao Wu
The microenvironment of degenerative intervertebral disk (IVD) is characteristic of a high concentration of lactic acid and low pH levels, whereas the underlying mechanism has not been clearly defined. Endoplasmic reticulum (ER) is the hub of interactions between environmental signals and cellular biological functions, the malfunction of which is closely involved in the pathogenesis of multiple disorders, including IVD degeneration (IVDD). This research mainly aims at exploring what role ER stress plays in the natural process of IVDD and pH-induced apoptosis of rat nucleus pulposus (NP) cells (NPCs)...
June 16, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28604508/symptomatic-adjacent-segment-disease-after-anterior-cervical-discectomy-for-single-level-degenerative-disk-disease
#3
Roland D Donk, Wim I M Verhagen, Allard J F Hosman, Andre Verbeek, Ronald H M A Bartels
STUDY DESIGN: A prospective cohort of 142 patients underwent either anterior cervical discectomy alone, anterior cervical discectomy with fusion by cage stand-alone, or anterior cervical discectomy with arthroplasty. We then followed up on their condition for a mean of 9.1±1.9 years (5.6-12.2 y) later. OBJECTIVE: We aimed to evaluate the annual rate of clinically symptomatic adjacent segment disease (ASD) and to analyze predictive factors. SUMMARY OF BACKGROUND DATA: Until recent, ASD has been predominantly evaluated radiologically...
June 9, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28580360/complete-cranial-iliac-osteotomy-to-approach-the-lumbosacral-foramen
#4
Barbara Dyall, Hugo Schmökel
An approach using a complete cranial iliac osteotomy (CCIO) to access the lumbosacral (LS) foramen in dogs from lateral was developed using cadavers and applied in a clinical patient with degenerative lumbosacral stenosis (DLSS). The foraminal enlargement in the cadavers and the patient was documented on postoperative CT scans. The preoperative CT scan of the patient showed moderate cranial telescoping of the sacral roof and a moderate central disk protrusion, leading to moderate to severe compression of the cauda equina...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28560045/correlation-of-neuter-status-and-expression-of-heritable-disorders
#5
Janelle M Belanger, Thomas P Bellumori, Danika L Bannasch, Thomas R Famula, Anita M Oberbauer
BACKGROUND: Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28525483/development-of-a-remodeled-caspar-retractor-and-its-application-in-the-measurement-of-distractive-resistance-in-an-in-vitro-anterior-cervical-distraction-model
#6
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of the cervical intervertebral distraction using a remodeled Caspar retractor. OBJECTIVE: To investigate the torques required for distraction to different heights in an in vitro C3-C4 anterior cervical distraction model using a remodeled Caspar retractor, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the torques required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525476/magnetic-resonance-classification-system-of-cervical-intervertebral-disk-degeneration-its-validity-and-meaning
#7
Akinobu Suzuki, Michael D Daubs, Tetsuo Hayashi, Monchai Ruangchainikom, Chenjie Xiong, Kevin Phan, Trevor P Scott, Jeffery C Wang
STUDY DESIGN: Retrospective analysis of kinetic magnetic resonance images (kMRIs). OBJECTIVE: (1) To analyze the changes seen on MRI related to disk degeneration and to develop a new grading system for cervical disk degeneration. (2) To evaluate the reliability and validity of the grading system. SUMMARY OF BACKGROUND DATA: Few have studied the relationship between changes seen on MRI with cervical disk degeneration and the chronological order of disk degeneration...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525470/factors-affecting-the-nonlinear-force-versus-distraction-height-curves-in-an-in-vitro-c5-c6-anterior-cervical-distraction-model
#8
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of cervical intervertebral distraction. OBJECTIVE: To investigate the forces required for distraction to different heights in an in vitro C5-C6 anterior cervical distraction model, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the forces required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28511287/generation-and-characterization-of-highly-purified-canine-schwann-cells-from-spinal-nerve-dorsal-roots-as-potential-new-candidates-for-transplantation-strategies
#9
Nicole Steffensen, Annika Lehmbecker, Ingo Gerhauser, Yimin Wang, Regina Carlson, Andrea Tipold, Wolfgang Baumgärtner, Veronika M Stein
Schwann cells (SCs) are promising candidates for transplantation-strategies in the central nervous system by promoting axonal regeneration. The dog represents a translational model for human spinal cord injury (SCI) for studies with new repair strategies after intervertebral disk herniation (IVDH). To overcome the necessity for an additional surgical procedure, for the first time a protocol for isolation, and purification of canine SCs from spinal-nerve-biopsies during standard hemilaminectomy in IVDH affected paraplegic dogs for potential transplantation was developed...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28468504/dynamic-mechanical-response-of-polyvinyl-alcohol-gelatin-theta-gels-for-nucleus-pulposus-tissue-replacement
#10
Patrick N Charron, Sarah E Blatt, Canaan McKenzie, Rachael A Oldinski
Intervertebral disk degeneration is one of the most significant contributors to low back pain. Thus, there is significant interest in designing new treatments and nucleus pulposus (NP) tissue replacements. Herein, the authors propose a biosynthetic material, comprised of a polyvinyl alcohol (PVA) and gelatin theta-gel, as an acellular NP tissue replacement. Theta-gels form during the solidification of PVA and gelatin (phase I), and the phase separation of a disklike short-chain polyethylene glycol (PEG, phase II)...
May 3, 2017: Biointerphases
https://www.readbyqxmd.com/read/28455212/cardiovascular-effects-and-intraoperative-pharmacokinetics-of-tramadol-in-sheep-undergoing-spinal-surgery
#11
Giulia Maria De Benedictis, Mario Giorgi, Alice Depase, Virginia De Vito, Giorgia Della Rocca, Luca Bellini
OBJECTIVE: To evaluate the pharmacokinetics of two doses of tramadol during isoflurane anaesthesia in sheep and their ability to prevent the cardiovascular response induced by surgical stimulation. STUDY DESIGN: Prospective randomized controlled study. ANIMALS: A total of 12 healthy sheep (mean weight, 47.5±7.9 kg) undergoing lumbar transpedicular intervertebral disk nucleotomy. METHODS: Sheep were sedated with medetomidine, anaesthesia was induced with propofol and maintained with isoflurane at 1...
February 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28451842/anterior-cervical-discectomy-without-fusion-for-a-symptomatic-cervical-disk-herniation
#12
Judith D de Rooij, Pravesh S Gadjradj, John S Soria van Hoeve, Biswadjiet S Harhangi
BACKGROUND: Cervical radiculopathy is characterized by dysfunction of the nerve root usually caused by a cervical disk herniation. The most important symptom is pain, radiating from the neck to the arm. When conservative treatment fails, surgical treatment is indicated to relieve symptoms. During the last decades, multiple fusion techniques have been developed, although without clinical evidence for added value of fusion over non-fusion. METHODS: The surgical procedure of anterior cervical discectomy without fusion is performed step by step, leading to removal of the entire intervertebral disk...
July 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28443163/using-magnetic-resonance-myelography-to-improve-interobserver-agreement-in-the-evaluation-of-lumbar-spinal-canal-stenosis-and-root-compression
#13
Haider Najim Al-Tameemi, Sattar Al-Essawi, Mahmud Shukri, Farah Kasim Naji
STUDY DESIGN: Cross-sectional retrospective study designed to assess interobserver agreement. PURPOSE: To investigate if interobserver agreement using magnetic resonance imaging (MRI) in the evaluation of lumbar spinal canal stenosis and root compression can be improved upon combination with magnetic resonance myelography (MRM). OVERVIEW OF LITERATURE: The interpretation of lumbar spinal MRI, which is the imaging modality of choice, often has a significant influence on the diagnosis and treatment of low back pain...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28440586/comparison-of-preoperative-quantitative-magnetic-resonance-imaging-and-clinical-assessment-of-deep-pain-perception-as-prognostic-tools-for-early-recovery-of-motor-function-in-paraplegic-dogs-with-intervertebral-disk-herniations
#14
A Wang-Leandro, J S Siedenburg, M K Hobert, P Dziallas, K Rohn, V M Stein, A Tipold
BACKGROUND: Prognostic tools to predict early postoperative motor function recovery (MFR) after thoracolumbar intervertebral disk herniation (IVDH) in paraplegic dogs represent an opportunity to timely implement novel therapies that could shorten recovery times and diminish permanent neurological dysfunctions. HYPOTHESIS: Fractional anisotropy (FA) values obtained using diffusion tensor imaging have a higher prognostic value than a lesion extension ratio in T2-weighted images (T2W-LER) and clinical assessment of deep pain perception (DPP) for MFR...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28437328/is-an-isolated-intervertebral-disk-with-significant-degeneration-magnetic-resonance-imaging-a-cause-of-low-back-pain-that-requires-no-confirmatory-diagnostic-tests
#15
George M Ghobrial, Joshua Heller, Daniel Cataldo, Christopher K Kepler
No abstract text is available yet for this article.
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28434574/50-years-ago-in-the-journal-of-pediatrics-intervertebral-disk-infection-in-children
#16
Sarah S Long
No abstract text is available yet for this article.
May 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28413773/a-m-%C3%A2-avium-complex-spondylodiscitis-in-a-middle-aged-woman-with-diabetes
#17
Irini Gerogianni, Stylianos Boutlas, Theophilos Karachalios, Eythymia Petinaki, Marianna Vlychou, K I Gourgoulianis
Spondylodiscitis, the inflammation of the vertebral bodies and the intervertebral disk space, is the reason for low back pain in a minority of cases. This is caused by various pathogens. Mycobacterium tuberculosis is responsible for 17-39% of all the cases of spondylodiscitis. On the contrast, spondylodiscitis from non tuberculous mycobacteria is extremely rare in literature. We describe a 68 -year old diabetic woman which is the first case of bone marrow involvement by M. intracellulare (member of M avium complex)with spondylodiscitis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28408266/analysis-of-clinical-results-of-three-different-routes-of-percutaneous-endoscopic-transforaminal-lumbar-discectomy-for-lumbar-herniated-disk
#18
Hyeun Sung Kim, Farid Yudoyono, Byapak Paudel, Jee Soo Jang, Jeong Hoon Choi, Sung Kyun Chung, Jeong Hoon Kim, Il Tae Jang, Seong Hoon Oh, Jae Eun Park, Sol Lee
OBJECTIVE: Percutaneous endoscopic transforaminal lumbar discectomy (PETLD) can be performed by using foraminal, intervertebral and suprapedicular routes. The aim of this study was to assess clinical results of three different routes of percutaneous endoscopic transforaminal lumbar discectomy (PETLD). METHODS: 111 patients who had undergone PETLD between January 2016 and October 2016 were included in this study. PETLD was performed by using the foraminal (group A), intervertebral (group B), and suprapedicular (group C) routes in 32, 46, and 33 patients, respectively...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28377644/finite-element-analysis-of-sagittal-balance-in-different-morphotype-forces-and-resulting-strain-in-pelvis-and-spine
#19
REVIEW
Vincenzo Filardi, Portaro Simona, Giorgio Cacciola, Salvatore Bertino, Luigi Soliera, Andrea Barbanera, Alessandro Pisani, Demetrio Milardi, Bramanti Alessia
In humans, vertical posture acquisition caused several changes in bones and muscles which can be assumed as verticalization. Pelvis, femur, and vertebral column gain an extension position which decreases muscular work by paravertebral muscles in the latter. It's widely known that six different morphological categories exist; each category differs from the others by pelvic parameters and vertebral column curvatures. Both values depend on the Pelvic Incidence, calculated as the angle between the axes passing through the rotation centre of the two femur heads and the vertical axis passing through the superior plate of the sacrum...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28350945/intervertebral-disk-degeneration-and-repair
#20
James Dowdell, Mark Erwin, Theodoe Choma, Alexander Vaccaro, James Iatridis, Samuel K Cho
Intervertebral disk (IVD) degeneration is a natural progression of the aging process. Degenerative disk disease (DDD) is a pathologic condition associated with IVD that has been associated with chronic back pain. There are a variety of different mechanisms of DDD (genetic, mechanical, exposure). Each of these pathways leads to a final common result of unbalancing the anabolic and catabolic environment of the extracellular matrix in favor of catabolism. Attempts have been made to gain an understanding of the process of IVD degeneration with in Vitro studies...
March 1, 2017: Neurosurgery
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