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https://www.readbyqxmd.com/read/28061487/thermal-induced-osteonecrosis-of-adjacent-vertebra-after-intradiscal-electrothermal-therapy
#1
Soonjoon Kim, Sun-Ho Lee, Eun-Sang Kim, Whan Eoh
A 42-year-old man was admitted to our hospital with complaints of low back pain and intermittent right thigh pain. Twelve weeks before admission, the patient received intradiscal electrothermal therapy (IDET) at a local hospital. The patient still reported low back pain after the procedure that was managed with narcotic analgesics. Follow-up magnetic resonance imaging (MRI) was performed, and his referring physician thought the likely diagnosis was spondylodiscitis at the L4-5 spinal segment with a small epidural abscess...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28050750/a-novel-modality-for-functional-imaging-in-acute-intervertebral-disk-herniation-via-tracking-leukocyte-infiltration
#2
Li Xiao, Mengmeng Ding, Yi Zhang, Mahendra Chordia, Dongfeng Pan, Adam Shimer, Francis Shen, David Glover, Li Jin, Xudong Li
PURPOSE: Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk herniation via the formyl peptide receptor 1 (FPR1)-mediated molecular imaging in a disk puncture mouse model to elucidate pathophysiological process of disk herniation...
January 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28050544/influence-of-mononuclear-cell-therapy-on-disc-degeneration-in-rabbits
#3
Rodrigo Caldonazzo Fávaro, André de Oliveira Arruda, Luiz Roberto Gomes Vialle, Emiliano Neves Vialle
OBJECTIVE: The objective of this research was to evaluate the influence of autologous mononuclear stem cells injections on histological changes of collagen in the fibrous annulus of the intervertebral disk after experimental injury. METHODS: 32 New Zealand rabbits were submitted to intervertebral disk puncture, followed by intradiscal injection of mononuclear cells from the iliac crest versus saline injection in the following time periods: two months after the injury (SC2M and SS2M), two weeks (SC2W and SS2W) immediately after injury (SCCP and SSCP), and without inducing degeneration (SCSP and SSSP)...
November 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28025450/application-of-fiber-tractography-and-diffusion-tensor-imaging-to-evaluate-spinal-cord-diseases-in-dogs
#4
Yuko Konishi, Hiroyuki Satoh, Yasuyoshi Kuroiwa, Mizuki Kusaka, Atsushi Yamashita, Yujiro Asada, Taketoshi Asanuma
Fiber tractography is a technique capable of depicting the three-dimensional structure and connectivity of nerve fibers using serial magnetic resonance diffusion tensor imaging (DTI). To establish fiber tractography and DTI methods in veterinary clinical medicine, we evaluated fiber tractography and DTI parameters: apparent diffusion coefficient (ADC) values and fractional anisotropy (FA) values, in various spinal cord diseases. Spinal cord DTI was examined in 28 dogs with spinal cord diseases. The ADC and FA values were measured at lesion sites and cranial normal sites on spinal cords, and both values of lesion sites were compared with normal sites...
December 23, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28017166/comparison-of-transforaminal-and-interlaminar-epidural-steroid-injections-for-the-treatment-of-chronic-lumbar-pain
#5
Serbülent Gökhan Beyaz
STUDY DESIGN: A cross-sectional study. OBJECTIVE: We compared the 12 month outcomes of fluoroscopically guided transforaminal epidural steroid injections with interlaminar epidural steroid injections for the treatment of chronic lumbar spinal pain. Chronic lower back pain is a multifactorial disorder with many possible etiologies. The lifetime prevalence of spinal pain is reportedly 65-80% in the neck and lower back. Epidural injection of corticosteroids is a commonly used intervention for managing chronic spinal pain...
January 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/27999827/cauda-equina-syndrome-an-emergency-some-unexpected-severe-symptoms-and-conservative-treatment
#6
Philip Grammaticos, Nikitas Papadopoulos, Labib Tarazi, Dimosthenis Katsarkas
An 83 years old physician, doing only office work and no exercise, presented with cauda equine, due to a large intervertebral disk hernia between L1-L2 vertebrae, after an unorthodox movement. He also had a facet syndrome, a muscular spasm in the gluteus, a small fracture in the periphery of the body of the L2 vertebra and pain in the L4-L5, due to a previous vertebral hernia five years ago. All L1-L5 left lateral area was painful. He felt an unbearable pain. He also had a degree of paralysis of the gastrointestinal (GI) and the genitourinary system...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27942133/effect-of-spinal-decompression-on-the-lumbar-muscle-activity-and-disk-height-in-patients-with-herniated-intervertebral-disk
#7
Jeong-Il Kang, Dae-Keun Jeong, Hyun Choi
[Purpose] This study was conducted to clarify the difference in therapeutic effects between traction and decompression therapies, and their clinical therapeutic significance. [Subjects and Methods] The subjects were 31 patients aged 35 to 50 years who had unilateral or bilateral lumbar and radicular leg pain. An intervention program was implemented in 31 patients with lumbar herniated intervertebral disks. For the experimental group, 15 subjects were randomly selected to receive decompression therapy and trunk stabilization exercise...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27933300/head-tilting-elicited-by-head-turning-in-three-dogs-with-hypoplastic-cerebellar-nodulus-and-ventral-uvula
#8
Shinji Tamura, Yuya Nakamoto, Takashi Uemura, Yumiko Tamura
The nodulus and ventral uvula (NU) of the cerebellum play a major role in vestibular function in humans and experimental animals; however, there is almost no information about NU function in the veterinary clinical literature. In this report, we describe three canine cases diagnosed with presumptive NU hypoplasia. Of them, one adult dog presented with cervical intervertebral disk disease, and two juvenile dogs presented with signs of central vestibular disease. Interestingly, an unusual and possibly overlooked neurological sign that we called "positioning head tilt" was observed in these dogs...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27925638/biomechanical-analysis-of-intervertebral-cement-extravasation-in-vertebral-motion-segments
#9
Trevor C Wahlquist, John J Lee, Alexander Brunfeldt, Geoffrey T Burns, Rakesh D Patel, Gregory P Graziano
Kyphoplasty is a therapeutic option for pain relief in the setting of compression fractures. Cement extravasation into adjacent disks is a common occurrence. The biomechanical and clinical consequences of cement in the disks currently are unknown. This study investigated the biomechanical effects of cement extravasation into the intervertebral disk in a human cadaveric model. Seven thoracolumbar and lumbar embalmed human cadaveric motion segments were evaluated in axial rotation, right and left lateral bending, and flexion and extension...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27901458/recurrence-of-disk-herniation-following-percutaneous-laser-disk-ablation-in-dogs-with-a-history-of-thoracolumbar-intervertebral-disk-herniation-303-cases-1994-2011
#10
Danielle R Dugat, Kenneth E Bartels, Mark E Payton
OBJECTIVE To determine rate of recurrence of disk herniation in dogs that underwent percutaneous laser disk ablation (PLDA) because of a previous episode of suspected or confirmed thoracolumbar intervertebral disk herniation (IVDH). DESIGN Retrospective case series. ANIMALS 303 dogs that underwent PLDA and for which a minimum of 3 years of follow-up information was available (n = 294) or for which recurrence was documented within 3 years after the procedure (9). PROCEDURES Information on signalment, previous episodes of IVDH, specifics of the PLDA procedure, and recurrence was obtained from the medical records...
December 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27875480/innovative-treatments-for-back-pain
#11
G Lorimer Moseley
Innovation involves asking new questions, or taking new approaches to old questions. For a problem as old as back pain, one might expect innovations to be rare. That back pain has been the most burdensome non-fatal health condition for over 25 years, and that the treatments that are available are not very effective, clearly points to the need for innovative approaches. The most eye-catching innovations of the last decade have taken novel approaches to the intervertebral disk, but the disconnect between back pain and structural pathology of the spine suggest that the impact of any so targeted approaches will be limited...
November 21, 2016: Pain
https://www.readbyqxmd.com/read/27872724/are-magnetic-resonance-imaging-or-radiographic-findings-correlated-with-clinical-prognosis-in-spinal-cord-neuropathy
#12
Fatemeh Neshat Halati, Alireza Vajhi, Mohammad Molazem, Mohammad Mehdi Dehghan, Fereshteh Ansari
Dogs presented to the Small Animal Hospital of Veterinary Medicine, University of Tehran were included in the present study if spinal or intervertebral disc involvement was suspected. Clinical signs were recorded as well as general information of the patient such as age, breed and sex. Sixty dogs were examined radiographically and two standard orthogonal lateral and ventrodorsal projections were taken from the suspected region. Then magnetic resonance imaging (MRI) was performed for all patients. Agreement between MRI and radiographic findings, comparison of sex and breed with diagnostic imaging grades, comparison between diagnostic imaging grades and mean age, recovery rate after surgery or medical treatment, effects of diagnostic imaging severity grades on surgical or medical referrals were evaluated statistically...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27853661/cell-therapy-with-human-dermal-fibroblasts-enhances-intervertebral-disk-repair-and-decreases-inflammation-in-the-rabbit-model
#13
Ana Chee, Peng Shi, Thomas Cha, Ting-Hsien Kao, Shu-Hua Yang, Jun Zhu, Ding Chen, Yejia Zhang, Howard S An
Study Design Pilot study using the rabbit model. Objective Low back pain is often associated with disk degeneration. Cell therapy for degenerating disks may promote tissue regeneration and repair. Human dermal fibroblasts, obtained from the patient's skin tissue or donated tissue, may be a promising cell therapy option for degenerating disks. The objective of these studies is to determine the effects of intradiscal transplantation of neonatal human dermal fibroblasts (nHDFs) on intervertebral disk (IVD) degeneration by measuring disk height, magnetic resonance imaging (MRI) signal intensity, gene expression, and collagen immunostaining...
December 2016: Global Spine Journal
https://www.readbyqxmd.com/read/27826214/clinical-outcome-following-diam-implantation-for-symptomatic-lumbar-internal-disk-disruption-a-3-year-retrospective-analysis
#14
Kang Lu, Po-Chou Liliang, Hao-Kuang Wang, Jui-Sheng Chen, Te-Yuan Chen, Ruyi Huang, Han-Jung Chen
BACKGROUND/OBJECTIVE: Internal disk disruption (IDD), an early event of lumbar disk degeneration, is the most common cause of low back pain. Since increased intradiskal pressure (IDP) is associated with symptoms and progression of disk degeneration, unloading a painful disk with an interspinous process device (IPD) is a rational treatment option. The goal of this study was to evaluate the effectiveness of dynamic stabilization with an IPD in the treatment of symptomatic IDD of the lumbar spine...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27807886/the-expression-of-cytokine-and-its-significance-for-the-intervertebral-disks-of-kazakhs
#15
Miao Xiaogang, Hou Quanshan, Zhang Liping, Habaxi Kaken
BACKGROUND: Proinflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 are expressed in herniated intervertebral disks of Kazakhs, but their significance is not yet understood. METHODS: Specimens of herniated lumbar disk were collected from 30 patients with single disk herniation during lumbar discectomy. As a control, 10 specimens were collected postmortem from the cadavers of individuals who did not die from spinal disease. The clinical symptoms in all cases were evaluated preoperation by the JOA index...
November 3, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27769098/expression-of-noggin-and-gremlin1-and-its-implications-in-fine-tuning-bmp-activities-in-mouse-cartilage-tissues
#16
Xiaodan Yu, Hiroko Kawakami, Naoyuki Tahara, Merissa Olmer, Shinichi Hayashi, Ryutaro Akiyama, Anindya Bagchi, Martin Lotz, Yasuhiko Kawakami
Increasing evidence supports the idea that bone morphogenetic proteins (BMPs) regulate cartilage maintenance in the adult skeleton. The aim of this study is to obtain insight into the regulation of BMP activities in the adult skeletal system. We analyzed expression of Noggin and Gremlin1, BMP antagonists that are known to regulate embryonic skeletal development, in the adult skeletal system by Noggin-LacZ and Gremlin1-LacZ knockin reporter mouse lines. Both reporters are expressed in the adult skeleton in a largely overlapping manner with some distinct patterns...
October 21, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27761804/the-presence-of-the-neuronal-nitric-oxide-synthase-isoform-in-the-intervertebral-disk
#17
Vitor Castania, Ana Carolina Issy, João Walter Silveira, Frederico Rogério Ferreira, Simoneide S Titze-de-Almeida, Fernando F B Resende, Nádia Rubia Ferreira, Ricardo Titze-de-Almeida, Helton L A Defino, Elaine Del Bel
Intervertebral disk degeneration is a progressive and debilitating disease with multifactorial causes. Nitric oxide (NO) might contribute to the cell death pathway. We evaluated the presence of the constitutive form of the neuronal NOS (nNOS) in both health and degenerated intervertebral disk through qPCR and immunohistochemistry. We also analyzed the potential role of nNOS modulation in the tail needle puncture model of intervertebral disk degeneration. Male Wistar rats were submitted to percutaneous disk puncture with a 21-gauge needle of coccygeal vertebras...
January 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/27755207/imaging-evaluation-and-relative-significance-in-cases-of-cervical-disk-allografting-radiographic-character-after-total-disk-transplantation
#18
Yu Ding, Di-Ke Ruan, Qing He, Li Sheng Hou, Jian Ning Lin, Hong Peng Cui
STUDY DESIGN: The clinical and radiologic data of total disk allografting (TDA) cases were collected and analyzed to explore the correlation between neurological function improvements and imaging changes. OBJECTIVE: The aim of the study was to assess the medium-term and long-term outcome and radiographic character after TDA, and, furthermore, to explore the significance of the changes of imaging signs after the transplantation. SUMMARY OF BACKGROUND DATA: Spinal fusion may result in the adjacent segment degeneration...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27755203/novel-hemi-staple-for-the-fusionless-correction-of-pediatric-scoliosis-influence-on-intervertebral-disks-and-growth-plates-in-a-porcine-model
#19
Mark Driscoll, Carl-Éric Aubin, Alain Moreau, Yaroslav Wakula, Samira Amini, Stefan Parent
STUDY DESIGN: In vivo porcine model utilized to evaluate the influence of an intravertebral fusionless growth modulating device (hemi-staple) on intervertebral disks and growth plates. OBJECTIVE: To evaluate the radiographic and histologic changes in disks and growth plates with the purpose of measuring influence of the explored hemi-staple. SUMMARY OF BACKGROUND DATA: Fusionless growth modulation for the early treatment of scoliosis should insure the long-term viability of the intervertebral disk and successfully reduce or arrest local growth...
November 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27755201/radiographic-adjacent-segment-degeneration-at-5-years-after-l4-5-posterior-lumbar-interbody-fusion-with-pedicle-screw-instrumentation-evaluation-by-computed-tomography-and-annual-screening-with-magnetic-resonance-imaging
#20
Shiro Imagama, Noriaki Kawakami, Yuji Matsubara, Taichi Tsuji, Tetsuya Ohara, Yoshito Katayama, Naoki Ishiguro, Tokumi Kanemura
STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To investigate adjacent segment degeneration (ASD) at 5 years after L4/5 posterior lumbar interbody fusion with pedicle screw instrumentation and L4/5 decompression surgery using plain radiographs, computed tomography (CT), and magnetic resonance imaging (MRI), with the evaluation of annual changes on MRI. SUMMARY OF BACKGROUND DATA: Methods of evaluation have been inconsistent among studies of ASD...
November 2016: Clinical Spine Surgery
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