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https://www.readbyqxmd.com/read/28798688/establishment-and-characterization-of-a-novel-rat-model-of-mechanical-low-back-pain-using-behavioral-pharmacologic-and-histologic-methods
#1
Arjun Muralidharan, Thomas S W Park, John T Mackie, Luiz G S Gimenez, Andy Kuo, Janet R Nicholson, Laura Corradini, Maree T Smith
Chronic low back pain (LBP), the leading cause of disability globally, is notoriously difficult to treat. Most rodent models of LBP mimic lumbar radicular pain rather than mechanical LBP. Here, we describe establishment of a new rat model of mechanical LBP that is devoid of a neuropathic component. Groups of adult male Sprague Dawley rats were anesthetized and their lumbar L4/L5 and L5/L6 intervertebral disks (IVDs) were punctured (0.5 mm outer diameter, 2mm-deep) 5 (LPB-5X), or 10 (LBP-10X) times per disk...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28796075/muscle-gap-approach-under-a-minimally-invasive-channel-technique-for-treating-long-segmental-lumbar-spinal-stenosis-a-retrospective-study
#2
Yang Bin, Wang De Cheng, Wang Zong Wei, Li Hui
This study aimed to compare the efficacy of muscle gap approach under a minimally invasive channel surgical technique with the traditional median approach.In the Orthopedics Department of Traditional Chinese and Western Medicine Hospital, Tongzhou District, Beijing, 68 cases of lumbar spinal canal stenosis underwent surgery using the muscle gap approach under a minimally invasive channel technique and a median approach between September 2013 and February 2016. Both approaches adopted lumbar spinal canal decompression, intervertebral disk removal, cage implantation, and pedicle screw fixation...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766519/-the-possibilities-for-diagnostics-of-prescription-of-death-coming-based-on-the-changes-in-the-lumbar-intervertebral-disks-the-comparison-of-the-morphological-immunohistochemical-and-topographical-findings
#3
V A Byval'tsev, I A Stepanov, A V Semenov, D V Perfil'ev, E G Belykh, L A Bardonova, S B Nikiforov, N P Sudakov, I V Bespyatykh, S L Antipina
The objective of the present study was the comprehensive analysis of the postmortem changes in the lumbar intervertebral disks within different periods after death. A total of seven vertebromotor segments were distinguished in the lumbosacral region of the vertebral column based on the examination of 7 corpses. All these segments were divided into three groups in accordance with the prescription of death coming as follows: up to 12 hours (group 1), between 12 and 24 hours (group 2), and between 24 and 36 hours (group 3) after death...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28765807/the-influence-of-lordotic-cages-on-creating-sagittal-balance-in-the-cmis-treatment-of-adult-spinal-deformity
#4
Neel Anand, Ryan B Cohen, Jason Cohen, Babak Kahndehroo, Sheila Kahwaty, Eli Baron
BACKGROUND: CMIS techniques are heavily dependent on placement of lateral interbody cages. Cages with an increased lordotic angle are being advocated to improve segmental lordosis and SVA. We assessed the segmental lordosis achieved with the individual cages. We further studied three variables and the effect each had on segmental lordosis: the lordosis angle of the cage, the position of the cage in the intervertebral space, and the level that it has been placed. METHODS: This is a retrospective study of 66 consecutive patients who underwent lateral interbody fusion using lordotic cages as part of CMIS correction of scoliosis from June 2012 to January 2016...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28765673/laser-biostimulation-effects-on-invertebral-disks-histological-evidence-on-intra-observer-samples-retrospective-double-blind-study
#5
Alfonso Tramontana, Roberto Sorge, Juan Carlos Miangolarra Page
Background and aims: The intervertebral disk degeneration is a pathological process determined by a decrease of mucopolysaccharides in the nucleus pulposus with the consequent dehydration and degeneration of the elastic fibers in the annulus fibrosus of the disk. The laser is a therapeutic tool that has, on the treated tissues, biostimulation effects with an increase of oxidative phosphorylation and production of ATP with an acceleration of the mucopolysaccharides synthesis with a consequent rehydration, biostimulation and production of new elastic fibers...
December 30, 2016: Laser Therapy
https://www.readbyqxmd.com/read/28757523/operative-techniques-of-percutaneous-endoscopic-mini-hemilaminectomy-using-a-uniportal-approach-in-dogs
#6
Hee-Sup Moon, Yong-Hyun Hwang, Hee-Chun Lee, Jae-Hoon Lee
The present study aimed to investigate the technical feasibility of percutaneous endoscopic mini-hemilaminectomy via a uniportal approach, and to evaluate the possibility of decompression and endoscopic examination of the thoracic and lumbar spinal canals in small dogs during such procedures. Fresh canine cadavers of mixed-breed dogs (n=7) were used in this study. Following injection of a barium and agarose mixture (BA-gel) to stimulate intervertebral disc herniation, percutaneous endoscopic mini-hemilaminectomy was performed using a lateral approach to the thoracic and lumbar vertebrae...
July 31, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28756059/spinenet-automated-classification-and-evidence-visualization-in-spinal-mris
#7
Amir Jamaludin, Timor Kadir, Andrew Zisserman
The objective of this work is to automatically produce radiological gradings of spinal lumbar MRIs and also localize the predicted pathologies. We show that this can be achieved via a Convolutional Neural Network (CNN) framework that takes intervertebral disc volumes as inputs and is trained only on disc-specific class labels. Our contributions are: (i) a CNN architecture that predicts multiple gradings at once, and we propose variants of the architecture including using 3D convolutions; (ii) showing that this architecture can be trained using a multi-task loss function without requiring segmentation level annotation; and (iii) a localization method that clearly shows pathological regions in the disc volumes...
July 21, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28744949/identification-of-a-new-mineralized-tissue-in-the-notochord-of-reared-siberian-sturgeon-acipenser-baerii
#8
Amandine Leprévost, Thierry Azaïs, Michael Trichet, Jean-Yves Sire
In a study aiming to improve knowledge on the mineralization of the axial skeleton in reared Siberian sturgeon (Acipenser baerii Brandt, 1869), we discovered a new mineralized tissue within the notochord. To our knowledge, such a structure has never been reported in any vertebrate species with the exception of the pathological mineralization of the notochord remains in degenerative intervertebral disks of mammals. Here, we describe this enigmatic tissue using X-ray microtomography, histological analyses and solid state NMR-spectroscopy...
July 25, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28676057/prevalence-of-neurological-disorders-in-french-bulldog-a-retrospective-study-of-343-cases-2002-2016
#9
Vincent Mayousse, Loïc Desquilbet, Aurélien Jeandel, Stéphane Blot
BACKGROUND: French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report the prevalences of neurological diseases in a large population of FB, presented with neurological signs between 2002 and 2016, and for which a definitive diagnosis was established. A secondary objective was to identify epidemiological characteristics regarding specific diseases in this singular breed...
July 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28672319/effect-of-radiofrequency-denervation-on-pain-intensity-among-patients-with-chronic-low-back-pain-the-mint-randomized-clinical-trials
#10
RANDOMIZED CONTROLLED TRIAL
Johan N S Juch, Esther T Maas, Raymond W J G Ostelo, J George Groeneweg, Jan-Willem Kallewaard, Bart W Koes, Arianne P Verhagen, Johanna M van Dongen, Frank J P M Huygen, Maurits W van Tulder
Importance: Radiofrequency denervation is a commonly used treatment for chronic low back pain, but high-quality evidence for its effectiveness is lacking. Objective: To evaluate the effectiveness of radiofrequency denervation added to a standardized exercise program for patients with chronic low back pain. Design, Setting, and Participants: Three pragmatic multicenter, nonblinded randomized clinical trials on the effectiveness of minimal interventional treatments for participants with chronic low back pain (Mint study) were conducted in 16 multidisciplinary pain clinics in the Netherlands...
July 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28670416/correlation-among-inflammatory-cytokine-expression-levels-degree-of-disk-degeneration-and-predominant-clinical-symptoms-in-patients-with-degenerated-intervertebral-discs
#11
Takeshi Sainoh, Kazuhide Inage, Sumihisa Orita, Masao Koda, Takeo Furuya, Kazuyo Yamauchi, Miyako Suzuki, Yoshihiro Sakuma, Go Kubota, Yasuhiro Oikawa, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori
STUDY DESIGN: Observational study. PURPOSE: To assess the correlation among inflammatory cytokine expression levels, degree of intervertebral disk (IVD) degeneration, and predominant clinical symptoms observed in degenerative disk disease (DDD). OVERVIEW OF LITERATURE: Low back pain (LBP) is associated with inflammatory cytokine expression levels, including those of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and nerve growth factor (NGF)...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28650880/downward-laminotomy-technique-for-hidden-zone-foraminal-disk-herniations-technical-notes-and-preliminary-results
#12
Sait Naderi, Mehmet R Onen
INTRODUCTION: Hidden zone foraminal herniations are among the more rare forms of herniations. As exploration is difficult, and there is a close relationship between the nerve root and pedicle, many surgical approaches have been proposed. The aim of this study was to describe downward laminotomy as a new approach to these herniations. MATERIALS AND METHODS: A downward laminotomy technique was used in 5 cases with hidden zone foraminal disk herniation with no extension to the intervertebral disk space...
June 23, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28629570/the-association-between-multiple-sclerosis-and-spondylosis-when-and-why
#13
Vasileios G Xydis, Anastasia K Zikou, Vassiliki Kostadima, Loukas G Astrakas, Paraskevi Kosta, Maria I Argyropoulou
OBJECTIVES: To evaluate risk factors for the development of cervical spine spondylosis (CSS) in patients with multiple sclerosis (MS) and to propose a pathogenetic mechanism. METHODS: Forty-two consecutive patients aged 23-66 years with MS and 42 age and sex matched controls were evaluated retrospectively; Clinical disability was evaluated with the expanded disability status scale (EDSS) and spasticity with the Asworth score. Total brain lesion volume (BLV), total grey matter (GM) volume and deep GM volume were assessed...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28622016/endoplasmic-reticulum-stress-is-involved-in-nucleus-pulposus-degeneration-and-attenuates-low-ph-induced-apoptosis-of-rat-nucleus-pulposus-cells
#14
Zhi-Yang Xie, Lu Chen, Feng Wang, Lei Liu, Cong Zhang, Kun Wang, Feng Cai, Arjun Sinkemanni, Xin Hong, Xiao-Tao Wu
The microenvironment of degenerative intervertebral disk (IVD) is characteristic of a high concentration of lactic acid and low pH levels, whereas the underlying mechanism has not been clearly defined. Endoplasmic reticulum (ER) is the hub of interactions between environmental signals and cellular biological functions, the malfunction of which is closely involved in the pathogenesis of multiple disorders, including IVD degeneration (IVDD). This research mainly aims at exploring what role ER stress plays in the natural process of IVDD and pH-induced apoptosis of rat nucleus pulposus (NP) cells (NPCs)...
August 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28604508/symptomatic-adjacent-segment-disease-after-anterior-cervical-discectomy-for-single-level-degenerative-disk-disease
#15
Roland D Donk, Wim I M Verhagen, Allard J F Hosman, Andre Verbeek, Ronald H M A Bartels
STUDY DESIGN: A prospective cohort of 142 patients underwent either anterior cervical discectomy alone, anterior cervical discectomy with fusion by cage stand-alone, or anterior cervical discectomy with arthroplasty. We then followed up on their condition for a mean of 9.1±1.9 years (5.6-12.2 y) later. OBJECTIVE: We aimed to evaluate the annual rate of clinically symptomatic adjacent segment disease (ASD) and to analyze predictive factors. SUMMARY OF BACKGROUND DATA: Until recent, ASD has been predominantly evaluated radiologically...
June 9, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28580360/complete-cranial-iliac-osteotomy-to-approach-the-lumbosacral-foramen
#16
Barbara Dyall, Hugo Schmökel
An approach using a complete cranial iliac osteotomy (CCIO) to access the lumbosacral (LS) foramen in dogs from lateral was developed using cadavers and applied in a clinical patient with degenerative lumbosacral stenosis (DLSS). The foraminal enlargement in the cadavers and the patient was documented on postoperative CT scans. The preoperative CT scan of the patient showed moderate cranial telescoping of the sacral roof and a moderate central disk protrusion, leading to moderate to severe compression of the cauda equina...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28560045/correlation-of-neuter-status-and-expression-of-heritable-disorders
#17
Janelle M Belanger, Thomas P Bellumori, Danika L Bannasch, Thomas R Famula, Anita M Oberbauer
BACKGROUND: Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of orthopedic conditions, cognitive decline, and a predisposition to some neoplasias. This study was designed specifically to identify if a correlation exists between neuter status and inherited conditions in a large aggregate cohort of dogs representing many different breeds...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28525483/development-of-a-remodeled-caspar-retractor-and-its-application-in-the-measurement-of-distractive-resistance-in-an-in-vitro-anterior-cervical-distraction-model
#18
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of the cervical intervertebral distraction using a remodeled Caspar retractor. OBJECTIVE: To investigate the torques required for distraction to different heights in an in vitro C3-C4 anterior cervical distraction model using a remodeled Caspar retractor, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the torques required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525476/magnetic-resonance-classification-system-of-cervical-intervertebral-disk-degeneration-its-validity-and-meaning
#19
Akinobu Suzuki, Michael D Daubs, Tetsuo Hayashi, Monchai Ruangchainikom, Chenjie Xiong, Kevin Phan, Trevor P Scott, Jeffery C Wang
STUDY DESIGN: Retrospective analysis of kinetic magnetic resonance images (kMRIs). OBJECTIVE: (1) To analyze the changes seen on MRI related to disk degeneration and to develop a new grading system for cervical disk degeneration. (2) To evaluate the reliability and validity of the grading system. SUMMARY OF BACKGROUND DATA: Few have studied the relationship between changes seen on MRI with cervical disk degeneration and the chronological order of disk degeneration...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525470/factors-affecting-the-nonlinear-force-versus-distraction-height-curves-in-an-in-vitro-c5-c6-anterior-cervical-distraction-model
#20
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of cervical intervertebral distraction. OBJECTIVE: To investigate the forces required for distraction to different heights in an in vitro C5-C6 anterior cervical distraction model, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the forces required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
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