Stefanos Roumeliotis, Athanasios Roumeliotis, Panagiotis I Georgianos, Elias Thodis, Leon J Schurgers, Katarzyna Maresz, Theodoros Eleftheriadis, Evangelia Dounousi, Giovanni Tripepi, Francesca Mallamaci, Vassilios Liakopoulos
Vascular calcification (VC) is an active process, resulting from the disturbance of balance between inhibitors and promoters of calcification, in favor of the latter. Matrix Gla Protein, a powerful inhibitor of VC, needs vitamin K to become active. In vitamin K depletion, plasma levels of the inactive form of MGP, dephosphorylated, uncarboxylated MGP (dp-ucMGP) are increased and associated with VC and cardiovascular (CV) outcomes. End Stage Renal Disease (ESRD) patients have increased circulating dp-ucMGP levels and accelerated VC...
2022: PloS One