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https://www.readbyqxmd.com/read/29332196/bioelectronic-modulation-of-carotid-sinus-nerve-activity-in-the-rat-a-potential-therapeutic-approach-for-type-2-diabetes
#1
Joana F Sacramento, Daniel J Chew, Bernardete F Melo, Matteo Donegá, Wesley Dopson, Maria P Guarino, Alison Robinson, Jesus Prieto-Lloret, Sonal Patel, Bradley J Holinski, Nishan Ramnarain, Victor Pikov, Kristoffer Famm, Silvia V Conde
AIMS/HYPOTHESIS: A new class of treatments termed bioelectronic medicines are now emerging that aim to target individual nerve fibres or specific brain circuits in pathological conditions to repair lost function and reinstate a healthy balance. Carotid sinus nerve (CSN) denervation has been shown to improve glucose homeostasis in insulin-resistant and glucose-intolerant rats; however, these positive effects from surgery appear to diminish over time and are heavily caveated by the severe adverse effects associated with permanent loss of chemosensory function...
January 14, 2018: Diabetologia
https://www.readbyqxmd.com/read/29331613/internal-carotid-artery-web-as-the-cause-of-recurrent-cryptogenic-ischemic-stroke
#2
Jon Antigüedad-Muñoz, Patricia de la Riva, Gorka Arenaza Choperena, Amaia Muñoz Lopetegi, Naiara Andrés Marín, Gorka Fernández-Eulate, Manuel Moreno Valladares, Maite Martínez Zabaleta
Carotid artery web is considered an exceptional cause of recurrent ischemic strokes in the affected arterial territory. The underlying pathology proposed for this entity is an atypical fibromuscular dysplasia. We present the case of a 43-year-old woman with no cardiovascular risk factors who had experienced 2 cryptogenic ischemic strokes in the same arterial territory within an 11-month period. Although all diagnostic tests initially yielded normal results, detailed analysis of the computed tomography angiography images revealed a carotid web; catheter angiography subsequently confirmed the diagnosis...
January 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29328847/an-anaesthesia-perspective-on-carotid-body-tumour-cbt-excision-a-twenty-year-case-series-at-the-singapore-general-hospital
#3
Deanna Wj Ng, Chris I Yam, Loong T Wong, Darren Lk Koh
Carotid body tumours (CBT) are extremely rare neoplasms that arise from chemoreceptor cells at the bifurcation of the carotid artery. This rarity poses a challenge for the anaesthetist when dealing with surgeries for the removal of CBT. Reports of associated perioperative morbidity range from twenty to forty percent. This paper reviews the perioperative anaesthetic management of CBT patients and challenges in our institution's 20 year experience on 13 surgical CBT resections.
October 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29325963/surgical-anatomy-of-the-eustachian-tube-for-endoscopic-transnasal-skull-base-surgery-a-cadaveric-and-radiological-study
#4
Noritaka Komune, Satoshi Matsuo, Koichi Miki, Yojiro Akagi, Ryota Kurogi, Koji Iihara, Takashi Nakagawa
OBJECTIVE: The endoscopic endonasal approach to the anatomically complex lateral skull base presents technical challenges. The use of the Eustachian tube as a landmark to identify the petrous internal carotid artery has recently been reported, and this study aims to define the anatomical relationship between the Eustachian tube and its surrounding structures using cadaveric dissection and radiologic analysis. METHODS: To clarify the relationship of the Eustachian tube with its surrounding structures, we performed endoscopic and microscopic dissection of four adult cadaveric heads, and analyzed computed topography scans from 20 patients...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29322480/intra-operative-video-characterization-of-carotid-artery-pulsation-patterns-in-case-series-with-post-endarterectomy-hypertension-and-hyperperfusion-syndrome
#5
Yiming Xiao, Hassan Rivaz, Hidetoshi Kasuya, Suguru Yokosako, Cristina Mindru, Jeanne Teitelbaum, Denis Sirhan, David Sinclair, Mark Angle, Benjamin W Y Lo
Cerebral hyperperfusion syndrome (CHS) is a complication that can occur after carotid endarterectomy (CEA), the treatment of choice to decrease the subsequent risk of fatal or disabling stroke for patients with symptomatic severe stenosis of the carotid artery. Because of its rarity and complexity, the mechanism of the condition is still unclear, making its prevention via prediction and monitoring challenging. This is especially true during surgery, when multiple factors can induce physiological changes, including blood pressure and baroreceptor functions, which are crucial factors for post-CEA hypertension and CHS...
January 10, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29314768/medium-and-long-chain-acylcarnitines-are-associated-with-osteoarthritis-severity-and-arterial-stiffness-in-end-stage-osteoarthritis-patients-a-case-control-study
#6
Kaspar Tootsi, Jaak Kals, Mihkel Zilmer, Kaido Paapstel, Aigar Ottas, Aare Märtson
AIM: Arterial pathology has been suggested to be involved in osteoarthritis (OA). Metabolic profiling enables the determination of low-molecular-weight molecules, which might further explain the pathogenesis of OA and its relationship with cardiovascular diseases (CVD). The aim of this study was to compare the metabolic profile of lipid metabolism-related compounds and arterial stiffness in OA patients and in controls. METHOD: The serum of 70 end-stage OA patients prior to joint replacement surgery and 82 age-matched controls were analyzed by the AbsoluteIDQ™ p180 kit (BIOCRATES Life Sciences AG, Innsbruck, Austria) using the targeted metabolomic approach...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29314596/multiplate%C3%A2-evaluation-of-acetylsalicylic-acid-efficacy-in-carotid-surgery-routine-and-genetic-influencing-factors
#7
S Roullet, S Labrouche, C Carrie, H Auque, X Berard, G Freyburger
BACKGROUND: Acetylsalicylic acid (ASA) is recommended before, during and after carotid endarterectomy (CEA). Efficacy of ASA is influenced by numerous biological and genotypic factors. OBJECTIVES: To determine the biological efficacy of ASA by using the Multiplate® method and to explore the biological parameters and genomic factors influencing this efficacy. METHODS: This descriptive cross-sectional study included all patients scheduled for CEA between January 2012 and April 2013...
January 3, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29310495/outcome-of-carotid-and-subclavian-blowout-syndrome-in-patients-with-pharynx-and-larynx-carcinoma-passing-a-standardized-multidisciplinary-treatment
#8
Constanze Gahleitner, Benedikt Hofauer, Katharina Storck, Andreas Knopf
BACKGROUND: Carotid blowout syndrome (CBS) is one of the most feared emergencies in the head and neck surgery and tends to occur in patients with head and neck cancer, wound complications, pharyngocutaneous fistulas, or after radio(chemo)therapy. CBS is always life threatening and associated with a 50% mortality/morbidity rate. METHODS: Between 2007 and 2015, a total of 51 patients who developed CBS caused by the tumour masses or after radio(chemo)therapy were included...
January 8, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29309707/safety-and-effectiveness-of-selective-carotid-angioplasty-prior-to-cardiac-surgery-a-single-centre-matched-case-control-study
#9
Zahra Hasani, Rudolf W M Keunen, Dénes L J Tavy, Arne Mosch, Barry B Mook-Kanamori, Sebastiaan F T M De Bruijn, Ali M Keyhan-Falsafi, Gerard J F Hoohenkerk, Gayleen Stephens, Eric Teeuws, Jan van Alphen, Hans van Overhagen, Frank E E Treurniet, Lucas van Dijk, Paulien M van Kampen
OBJECTIVES: Reducing the rate of postoperative stroke after cardiac surgery remains challenging, especially in patients with occlusive cerebrovascular disease. Angioplasty in all patients with high-grade carotid artery stenosis has not been shown to be effective in reducing the post-surgical stroke rate. In this study, we present the initial results of a different approach using selective carotid angioplasty only in patients with poor intracranial collaterals. METHODS: We conducted a single-centre study to assess the safety of this procedure...
January 3, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29306627/favourable-outcomes-of-endovascular-total-aortic-arch-repair-via-needle-based-in-situ-fenestration-at-a-mean-follow-up-of-5-4%C3%A2-months
#10
Tao Shang, Lu Tian, Dong-Lin Li, Zi-Heng Wu, Hong-Kun Zhang
OBJECTIVES: Endovascular repair of aortic arch pathologies remains challenging. Recently, needle based in situ fenestration (ISF) has shown great potential in endovascular total aortic arch repair (ETAAR). This study aimed to evaluate the feasibility, effectiveness, and safety of ETAAR via needle based ISF, and to present initial experience with this technique. DESIGN AND METHODS: Patients who met the inclusion criteria were enrolled in this prospective study. The supra-arch branches were manually punctured in a retrograde manner using liver biopsy needles (18 gauge/30 cm) in the left common carotid artery (LCCA) and brachiocephalic trunk (BCT), and endo-puncture system or aspiration biopsy needles (21-gauge) in the left subclavian artery (LSA)...
January 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29301628/platelet-derived-mrp-14-induces-monocyte-activation-in-patients-with-symptomatic-peripheral-artery-disease
#11
Rebecca Dann, Tarik Hadi, Emilie Montenont, Ludovic Boytard, Dornaszadat Alebrahim, Jordyn Feinstein, Nicole Allen, Russell Simon, Krista Barone, Kunihiro Uryu, Yu Guo, Caron Rockman, Bhama Ramkhelawon, Jeffrey S Berger
BACKGROUND: Peripheral artery disease (PAD), a diffuse manifestation of atherothrombosis, is a major cardiovascular threat. Although platelets are primary mediators of atherothrombosis, their role in the pathogenesis of PAD remains unclear. OBJECTIVES: The authors sought to investigate the role of platelets in a cohort of symptomatic PAD. METHODS: The authors profiled platelet activity, mRNA, and effector roles in patients with symptomatic PAD and in healthy controls...
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29301059/objective-validation-of-perfusion-based-human-cadaveric-simulation-training-model-for-management-of-internal-carotid-artery-injury-in-endoscopic-endonasal-sinus-and-skull-base-surgery
#12
Jasper Shen, Kevin Hur, Zhipeng Zhang, Michael Minneti, Martin Pham, Bozena Wrobel, Gabriel Zada
BACKGROUND: The emergence of minimally invasive endoscopic endonasal skull base surgery has necessitated reproducible and realistic simulators of rare vascular injuries. OBJECTIVE: To assess the face and content validity of an innovative perfusion-based cadaveric model developed to simulate internal carotid artery (ICA) injury during endoscopic surgery. METHODS: Otolaryngology and neurosurgery trainees attempted 3 consecutive trials of endoscopic control of a parasellar ICA injury, with standardized technical feedback...
December 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29290519/reduced-intercarotid-artery-distance-in-syndromic-and-isolated-brachycephaly
#13
Reza Assadsangabi, Mehrdad Hajmomenian, Seyed Ali Nabavizadeh, James Eric Schmitt, Arastoo Vossough
INTRODUCTION: The morphology of the skull base can be altered in craniosynostoses. The objective of this study is to evaluate the reduced intercarotid artery distance in the lacerum segment in patients with syndromic and isolated brachycephaly. MATERIALS AND METHODS: The distances between the inner walls of the carotid canal at the lacerum segment were measured on high-resolution CT scans in children with Crouzon (25), Pfeiffer (21), Apert (26), Saethre-Chotzen (7) syndromes, isolated bicoronal synostosis (9), and compared to an age-matched control group (30)...
October 9, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29288397/a-cadaveric-study-of-aortic-arch-variation-in-an-irish-population
#14
Aisling M O'Malley, Walid H El Kininy, Helina Debebe, Azreena B Burukan, Shane W Davy
AIM: The aim of this study is to investigate the incidence of variation in the branching pattern of aortic arch (AA) vessels in an Irish population. METHOD: A cadaveric study of 24 subjects was conducted. The vessels of the AA were identified, their branching patterns were noted and photographed and the following measurements were recorded: the angle of the AA to the coronal plane, the distance from the midline to the brachiocephalic trunk (BCT); the left common carotid artery (LCC) ; the left subclavian artery (LSC), the distance between the BCT and the right subclavian artery (RSC); the RSC and the right vertebral artery (RVA), and between the LSC and left vertebral artery (LVA)...
December 29, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29286024/-subclavian-carotid-replacement-in-chronic-cerebrovascular-insufficiency-management
#15
A B Stepanenko, E R Charchyan, A P Gens, S V Fedulova, M N Seleznev, P N Shvedov
AIM: To present own experience of subclavian-carotid replacement for chronic cerebrovascular insufficiency management. MATERIAL AND METHODS: For 12 years 7 subclavian-carotid reconstructions were performed that was 1.2% of all carotid repairs during this period. Great saphenous vein was always used as a graft. Carotid endarterectomy from proximal internal carotid artery was additionally performed if it was necessary. Patients had severe advanced lesion of supra-aortic vessels including bilateral carotid lesion and significant stenosis of ipsilateral proximal common carotid artery...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29285704/direct-perfusion-of-the-carotid-artery-in-patients-with-brain-malperfusion-secondary-to-acute-aortic-dissection
#16
Yutaka Okita, Yuki Ikeno, Koki Yokawa, Yojiro Koda, Soichiro Henmi, Yasuko Gotake, Hidekazu Nakai, Takashi Matsueda, Takeshi Inoue, Hiroshi Tanaka
OBJECTIVE: Presenting our experience of direct perfusion of the carotid artery in patients with brain malperfusion secondary to acute aortic dissection. PATIENTS: Among 381 patients who underwent aortic repair for acute type A aortic dissection from October 1999 to August 2017, brain malperfusion was recognized in 50 patients. Nine patients had direct perfusion of the right carotid artery in patients with brain malperfusion secondary to acute aortic dissection. Age at surgery was 65...
December 28, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29284341/cerebral-perfusion-monitoring-in-adult-patients-following-cardiac-surgery-an-observational-study
#17
Tammy Slater, Julie Stanik-Hutt, Patricia Davidson
BACKGROUND: Strokes following adult cardiac surgery contribute to burdensome neurocognitive complications, which are often difficult to detect during the perioperative period. Fluctuations in regional cerebral perfusion and co-morbid conditions, such as hypertension, diabetes, prior stroke, symptomatic carotid stenosis, aortic atherosclerotic disease, and peripheral vascular disease are associated with perioperative strokes. Approaches to achieve optimal cerebral perfusion remain elusive and traditional strategies for perioperative monitoring are not always sufficiently sensitive to detect acute changes in cerebral perfusion...
December 28, 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/29280026/management-of-non-functioning-pituitary-adenomas-surgery
#18
REVIEW
David L Penn, William T Burke, Edward R Laws
Non-functional pituitary adenomas (NFPAs) are benign tumors of the pituitary gland that do not over-secrete hormonal products, therefore, they are generally detected through symptoms of mass effect, including headache, vision loss, or hypopituitarism. There are multiple pathological subtypes of NFPAs, such as null cell adenomas, silent gonadotrophs, silent somatotrophs, silent corticotrophs, and silent subtype 3, all of which can be classified based on immunohistochemical studies and electron microscopy. Despite these numerous pathological subtypes, surgical resection remains the first-line treatment for NFPAs...
December 26, 2017: Pituitary
https://www.readbyqxmd.com/read/29276105/grip-strength-measurement-for-frailty-assessment-in-patients-with-vascular-disease-and-associations-with-comorbidity-cardiac-risk-and-sarcopenia
#19
Thomas E Reeve, Rebecca Ur, Timothy E Craven, James H Kaan, Matthew P Goldman, Matthew S Edwards, Justin B Hurie, Gabriela Velazquez-Ramirez, Matthew A Corriere
OBJECTIVE: Frailty is associated with adverse events, length of stay, and nonhome discharge after vascular surgery. Frailty measures based on walking-based tests may be impractical or invalid for patients with walking impairment from symptoms or sequelae of vascular disease. We hypothesized that grip strength is associated with frailty, comorbidity, and cardiac risk among patients with vascular disease. METHODS: Dominant hand grip strength was measured during ambulatory clinic visits among patients with vascular disease (abdominal aortic aneurysm [AAA], carotid stenosis, and peripheral artery disease [PAD])...
December 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29262391/-ruptured-dissecting-aneurysm-of-m2-portion-of-the-middle-cerebral-artery-a-case-report
#20
Yutaka Fukushima, Tomohiro Takaki, Shinichiro Yoshino, Katsuyuki Hirakawa, Tooru Inoue
A 71-year-old woman presented with a sudden onset of headache and vomiting. Computed tomography(CT)showed diffuse subarachnoid hemorrhage(SAH)that was more severe on the right side. Three-dimensional CT angiography and right carotid angiography(CAG)demonstrated 2-mm microaneurysms at the middle cerebral artery(MCA)bifurcation and anterior communicating artery, with slight narrowing and dilatation of the M2 inferior trunk. Each microaneurysm was smooth, making it difficult to identify the bleeding source. Thus, surgery was postponed at the acute stage, and further investigation was planned...
December 2017: No Shinkei Geka. Neurological Surgery
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