D Dannehl, D Jakob, F Mergel, A Estler, T Engler, L Volmer, M-L Frevert, S Matovina, A Englisch, C M Tegeler, A Rohner, A Seller, M Hahn, K Pfister, A Fink, I Popp, S Lorenz, G Tabatabai, I Juhasz-Böss, W Janni, S Brucker, F-A Taran, A Hartkopf, H Schäffler
BACKGROUND: Fifteen to thirty percent of all patients with metastatic breast cancer (MBC) develop brain metastases (BCBMs). Recently, the antibody-drug conjugates (ADCs) sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd) have shown to be highly effective in the treatment of MBC. However, there are only limited data whether these macromolecules are also effective in patients with BCBMs. We therefore aimed to examine the efficacy of SG and T-DXd in patients with stable and active BCBMs in a multicenter real-world analysis...
April 17, 2024: ESMO Open