Yu Chen, Sihan Liu, Zongyao Ren, Feiran Wang, Yi Jiang, Rujia Dai, Fangyuan Duan, Cong Han, Zhilin Ning, Yan Xia, Miao Li, Kai Yuan, Wenying Qiu, Xiao-Xin Yan, Jiapei Dai, Richard F Kopp, Jufang Huang, Shuhua Xu, Beisha Tang, Eric R Gamazon, Tim Bigdeli, Elliot Gershon, Hailiang Huang, Chao Ma, Chunyu Liu, Chao Chen
Research on brain expression quantitative trait loci (eQTLs) has illuminated the genetic underpinnings of schizophrenia (SCZ). Yet, the majority of these studies have been centered on European populations, leading to a constrained understanding of population diversities and disease risks. To address this gap, we examined genotype and RNA-seq data from African Americans (AA, n=158), Europeans (EUR, n=408), and East Asians (EAS, n=217). When comparing eQTLs between EUR and non-EUR populations, we observed concordant patterns of genetic regulatory effect, particularly in terms of the effect sizes of the eQTLs...
February 16, 2024: medRxiv