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https://www.readbyqxmd.com/read/29691272/immune-mediated-necrotising-myopathy-a-rare-cause-of-hyperckaemia
#1
Emily Liang, Mandana Rastegar
Immune-mediated necrotising myopathy (IMNM) is a type of inflammatory myopathy characterised by acute or subacute severe proximal muscle weakness, significantly elevated creatine kinase levels, and prominent myofibre necrosis and regeneration with little or no inflammation. A subtype of IMNM identified by anti-HMG-CoA reductase (HMGCR)antibodies has been shown to be associated with statin exposure. Treatment of IMNM consists of immunosuppression with steroids, steroid-sparing agents, intravenous immune globulin and/or biologics...
April 24, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29684566/eltrombopag-for-the-treatment-of-of-refractory-pure-red-cell-aplasia-after-major-abo-incompatible-hematopoietic-stem-cell-transplantation
#2
Alessandro Busca, Chiara Dellacasa, Luisa Giaccone, Sara Manetta, Lucia Biale, Laura Godio, Semra Aydin, Moreno Festuccia, Lucia Brunello, Benedetto Bruno
Pure red cell aplasia (PRCS) is a well-recognized complication after allogeneic hematopoietic stem cell transplantation (HSCT). Many therapeutic options are available to treat this condition, including erythropoietin, rituximab, bortezomib, plasma exchange, immunoadsorption, donor lymphocyte infusion, mesenchymal stem cells, anti-thymocyte globulin and high-dose steroids; however treatment outcomes are often variable and can sometimes lead to disappointing results. In this brief article we report our experience with two patients with PRCA after major AB0-incompatible HSCT who were resistant to multiple therapeutic interventions and who eventually benefited from treatment with eltrombopag, a thrombopoietin mimetic approved by the Food and Drug Administration for the treatment of patients with immune thrombocytopenic purpura or severe aplastic anemia (SAA), refractory to immunosuppressive agents or not eligible to HSCT...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29668540/aplastic-anemia-as-an-immune-mediated-complication-of-thymoma-a-case-report
#3
Ersin Toret, Bengü Demirag, Sultan A Köker, Onur Doyurgan, Malik Ergin, Sinan Genc, Tuba H Karapinar, Yilmaz Ay, Yeşim Oymak, Canan Vergin
Thymomas are the most common masses located in the anterior mediastinum, and they are often associated with autoimmune disorders including myasthenia gravis, polymyositis, and aplastic anemia (AA). Autoreactive T-cell clones generated by the thymoma may lead to autoimmune disorders. We report the case of a 14-year-old boy who was examined for AA, and the underlying cause was determined to be an immune-mediated complication of thymoma. He had no matched sibling donors. He underwent thymectomy, and 3 months later he was treated with immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A...
April 17, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29603406/metaphylactic-effect-of-minerals-on-the-immune-response-biochemical-variables-and-antioxidant-status-of-newborn-calves
#4
T Tomasi, A Volpato, W A B Pereira, L H Debastiani, N B Bottari, V M Morsch, M R C Schetinger, M L R Leal, G Machado, A S Da Silva
The aim of this study was to evaluate whether injectable zinc and copper affect host immune responses and antioxidant status of newborn calves. For this study, 19 newborn calves were divided into two groups. The control group consisted of 10 animals; and the treated group consisted of nine animals that received copper edetate (Cu-ed) and zinc edetate (Zn-ed) subcutaneously at the first day of life at doses of 0.3 mg/kg and 1.0 mg/kg respectively. Blood and faecal samples were collected for laboratory analyses (seric biochemistry, proteinogram, antioxidant enzymes and parasitological examination) on days 10, 20 and 30 after birth...
March 30, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29582477/immune-molecular-profiling-of-whole-blood-drawn-from-a-non-human-primate-cardiac-xenograft-model-treated-with-anti-cd154-monoclonal-antibodies
#5
Sun A Ock, Keon Bong Oh, Seongsoo Hwang, Ik Jin Yun, Curie Ahn, Hyun Ken Chee, Hwajung Kim, Imran Ullah, Gi-Sun Im, Eung Woo Park
Most studies of xenografts have been carried out with complex immunosuppressive regimens to prevent immune rejection; however, such treatments may be fatal owing to unknown causes. Here, we performed immune molecular profiling following anti-CD154 monoclonal antibody (mAb) treatment in heterotopic abdominal cardiac xenografts from α-1,3-galactosyltransferase-knockout pigs into cynomolgus monkeys to elucidate the mechanisms mediating the undesirable fatal side effects of immunosuppressive agents. Blood samples were collected from healthy monkeys as control and then at 2 days after xenograft transplantation and just before humane euthanasia; 94 genes related to the immune system were analyzed...
March 26, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29570917/kinetic-of-the-cmv-specific-t-cell-immune-response-and-cmv-infection-in-cmv-seropositive-kidney-transplant-recipients-receiving-rabbit-anti-thymocyte-globulin-induction-therapy-a-pilot-study
#6
Cecilia Martín-Gandul, Pilar Pérez-Romero, Damián Mena-Romo, Alejandro Molina-Ortega, Francisco M González-Roncero, Marta Suñer, Gabriel Bernal, Elisa Cordero
BACKGROUND: Some studies have suggested that rATG treatment may be associated with an increased incidence of CMV infection and delayed CMV immune response. However, the evidences supporting this matter are scarce. This study aims to characterize the kinetic of the CMV-specific T-cell immune response before and after rATG induction therapy and the relationship with the development of CMV infection in CMV-seropositive kidney transplant recipients. METHODS: An observational prospective study of CMV-seropositive kidney transplant patients that received rATG induction therapy was performed...
March 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29554313/effect-of-direct-fed-microbial-addition-in-guinea-fowl-numida-meleagris-diets-on-performance-and-health-responses
#7
G K Sarfo, A Larbi, J A Hamidu, A Donkoh
The present study was conducted to investigate the effect of intermittent use of direct-fed microbial addition (DFM-"RE3®") on growth performance and health status of indigenous guinea fowls in northern Ghana. One-hundred and eighty day-old guinea keets were randomly assigned to 4 direct-fed microbial (DFM) treatments that included: control, daily, 3 consecutive days per wk (3CDW), and 7 days repeated every other wk (7DREOW) at 1.5 ml/L through water from day 1 to 56 days. Feed intake, body weight gain, and blood hematological and serum biochemical properties were recorded...
March 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/29535105/filgrastim-enhances-t-cell-clearance-by-antithymocyte-globulin-exposure-after-unrelated-cord-blood-transplantation
#8
Coco de Koning, Julie-Anne Gabelich, Jurgen Langenhorst, Rick Admiraal, Jurgen Kuball, Jaap Jan Boelens, Stefan Nierkens
Residual antithymocyte globulin (ATG; Thymoglobulin) exposure after allogeneic hematopoietic (stem) cell transplantation (HCT) delays CD4+ T-cell immune reconstitution (CD4+ IR), subsequently increasing morbidity and mortality. This effect seems particularly present after cord blood transplantation (CBT) compared to bone marrow transplantation (BMT). The reason for this is currently unknown. We investigated the effect of active-ATG exposure on CD4+ IR after BMT and CBT in 275 patients (CBT n = 155, BMT n = 120; median age, 7...
March 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/29523211/pediatric-rheumatology-infusion-center-report-on-therapeutic-protocols-and-infusions-given-over-4-years-with-focus-on-adverse-events-over-1-year
#9
Surabhi S Vinod, Annelle B Reed, Jamelle Maxwell, Randy Q Cron, Matthew L Stoll
BACKGROUND: Children with chronic rheumatic disease often require intravenous (IV) therapy. Our center has instituted standardized protocols for use of IV medications in rheumatology patients. Herein, we introduce the therapeutic protocols and report on their short-term safety. METHODS: This was an institutional review board (IRB) approved retrospective chart review of all patients who had received IV infusions between the years 2012 and 2015 at a single center, prescribed by a pediatric rheumatologist...
March 9, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29515582/cd4-t-cell-help-is-mandatory-for-naive-and-memory-donor-specific-antibody-responses-impact-of-therapeutic-immunosuppression
#10
Chien-Chia Chen, Alice Koenig, Carole Saison, Suzan Dahdal, Guillaume Rigault, Thomas Barba, Morgan Taillardet, Dimitri Chartoire, Michel Ovize, Emmanuel Morelon, Thierry Defrance, Olivier Thaunat
Antibody-mediated rejection is currently the leading cause of transplant failure. Prevailing dogma predicts that B cells differentiate into anti-donor-specific antibody (DSA)-producing plasma cells only with the help of CD4+ T cells. Yet, previous studies have shown that dependence on helper T cells decreases when high amounts of protein antigen are recruited to the spleen, two conditions potentially met by organ transplantation. This could explain why a significant proportion of transplant recipients develop DSA despite therapeutic immunosuppression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29478357/insights-into-thermal-stress-in-japanese-quail-coturnix-coturnix-dynamics-of-immunoendocrine-and-biochemical-responses-during-and-after-chronic-exposure
#11
Franco Nicolas Nazar, Emiliano Ariel Videla, Maria Emilia Fernandez, Maria Carla Labaque, Raul Hector Marin
Avian require comfortable temperatures for optimal development and heat stress is a high concern in warm weather countries. We aimed to assess the dynamics of immunoendocrine and biochemical variables responses of birds exposed to a heat stressor applied during daylight hours, during the chronic stress and the recovery periods. We hypothesize that variables involved in the birds response will be differentially and gradually modified during those periods. Female quail (n = 210) were housed in six rearing boxes...
February 25, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29475762/safety-and-immunogenicity-of-investigational-recombinant-botulinum-vaccine-rbv-a-b-in-volunteers-with-pre-existing-botulinum-toxoid-immunity
#12
Jessica M Khouri, Ruth N Motter, Stephen S Arnon
OBJECTIVES: We undertook an open-label, uncontrolled study of investigational recombinant botulinum vaccine for botulinum neurotoxin (BoNT) serotypes A and B (rBV A/B) to assess its safety and immunogenicity in healthy volunteers who had been previously immunized with investigational pentavalent botulinum toxoid. Study participants who wished to do so could donate their hyperimmune plasma for production of Human Botulism Immune Globulin Intravenous (BIG-IV, BabyBIG®). STUDY DESIGN: A single 0...
February 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29469742/unique-urticarial-presentation-of-minocycline-induced-lupus-erythematosus
#13
Ashley K Clark, Vivian Y Shi, Raja K Sivamani
The association between guttate psoriasis and infection with group A Streptococcus (GAS) has been well established in the medical literature. However, responses to treatments aimed at GAS eradication such as systemic antibiotics or tonsillectomy are inconsistent. Further complicating treatment recommendations for a disease with a suspected microbial trigger, the standard therapy for severe psoriasis is with systemic immunosuppressant medications. This case report illustrates the role of GAS as a trigger for acute onset severe psoriasis in a child whose skin disease initially worsened with a trial of methotrexate...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29465588/chart-validation-of-inpatient-international-classification-of-diseases-ninth-revision-clinical-modification-icd-9-cm-administrative-diagnosis-codes-for-venous-thromboembolism-vte-among-intravenous-immune-globulin-igiv-users-in-the-sentinel-distributed-database
#14
Eric M Ammann, Adam Cuker, Ryan M Carnahan, Usha S Perepu, Scott K Winiecki, Marin L Schweizer, Charles E Leonard, Candace C Fuller, Crystal Garcia, Cole Haskins, Elizabeth A Chrischilles
The Sentinel Distributed Database (SDD) is a database of patient administrative healthcare records, derived from insurance claims and electronic health records, sponsored by the US Food and Drug Administration for evaluation of medical product outcomes. There is limited information on the validity of diagnosis codes for acute venous thromboembolism (VTE) in the SDD and administrative healthcare data more generally.In this chart validation study, we report on the positive predictive value (PPV) of inpatient administrative diagnosis codes for acute VTE-pulmonary embolism (PE) or lower-extremity or site-unspecified deep vein thrombosis (DVT)-within the SDD...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29446185/chart-validation-of-inpatient-icd-9-cm-administrative-diagnosis-codes-for-acute-myocardial-infarction-ami-among-intravenous-immune-globulin-igiv-users-in-the-sentinel-distributed-database
#15
Eric M Ammann, Marin L Schweizer, Jennifer G Robinson, Jayasheel O Eschol, Rami Kafa, Saket Girotra, Scott K Winiecki, Candace C Fuller, Ryan M Carnahan, Charles E Leonard, Cole Haskins, Crystal Garcia, Elizabeth A Chrischilles
BACKGROUND: The Sentinel Distributed Database (SDD) is a large database of patient-level administrative health care records, primarily derived from insurance claims and electronic health records, and is sponsored by the US Food and Drug Administration for medical product safety evaluations. Acute myocardial infarction (AMI) is a common study endpoint for drug safety studies that rely on health records from the SDD and other administrative databases. PURPOSE: In this chart validation study, we report on the positive predictive value (PPV) of inpatient International Classification of Diseases, Ninth Revision, Clinical Modification AMI administrative diagnosis codes (410...
February 15, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29399100/effect-of-hbig-combined-with-hepatitis-b-vaccine-on-blocking-hbv-transmission-between-mother-and-infant-and-its-effect-on-immune-cells
#16
Junling Gong, Xing Liu
The effect of hepatitis B immune globulin (HBIG) combined with hepatitis B vaccine on blocking hepatitis B virus (HBV) transmission between mother and infant and its effect on immune cells were studied. Ninety newborn infants confirmed to be HBV surface antigen (HBsAg)-positive were divided equally into three groups. Group A newborns received the hepatitis B vaccine at 0, 1 and 6 months after birth (10 µg/time). Group B newborns received an intramuscular injection of 100 IU HBIG 2 h after birth before the same treatment as group A...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29391076/gamunex%C3%A2-in-guillain-barr%C3%A3-syndrome-a-postmarketing-retrospective-observational-study
#17
Zaeem A Siddiqi, Kecia Courtney, Kim Hanna, Elsa Mondou, Vera Bril
BACKGROUND: The objective of this retrospective study was to evaluate the effectiveness and safety of Gamunex® (immune globulin [human] 10%; hereinafter "Gamunex") when administered intravenously in the initial treatment of Guillain-Barré syndrome (GBS). The study was conducted as a postapproval commitment for Health Canada. METHODS: A medical chart review for hospitalized patients diagnosed with GBS and treated with Gamunex (Gamunex 10% and IGIVnex® 10%; N=109; n=69 evaluable) was conducted at seven Canadian study centers in reverse chronological order...
November 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29384925/chart-validation-of-inpatient-icd-9-cm-administrative-diagnosis-codes-for-ischemic-stroke-among-igiv-users-in-the-sentinel-distributed-database
#18
Eric M Ammann, Enrique C Leira, Scott K Winiecki, Nandakumar Nagaraja, Sudeepta Dandapat, Ryan M Carnahan, Marin L Schweizer, James C Torner, Candace C Fuller, Charles E Leonard, Crystal Garcia, Madelyn Pimentel, Elizabeth A Chrischilles
The Sentinel Distributed Database (SDD) is a large database of patient-level medical and prescription records, primarily derived from insurance claims and electronic health records, and is sponsored by the U.S. Food and Drug Administration for drug safety assessments. In this chart validation study, we report on the positive predictive value (PPV) of inpatient ICD-9-CM acute ischemic stroke (AIS) administrative diagnosis codes (433.x1, 434.xx, and 436) in the SDD.As part of an assessment of the risk of thromboembolic adverse events following treatment with intravenous immune globulin (IGIV), charts were obtained for 131 potential post-IGIV AIS cases...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29330815/supplementing-dietary-rosemary-rosmarinus-officinalis-l-powder-and-vitamin-e-in-broiler-chickens-evaluation-of-humoral-immune-response-lymphoid-organs-and-blood-proteins
#19
Hossein Rostami, Alireza Seidavi, Mohammad Dadashbeiki, Yadollah Asadpour, João Simões, Assar Ali Shah, Vito Laudadio, Caterina Losacco, Antonella Perillo, Vincenzo Tufarelli
The aim of the present study was to evaluate the effect rosemary (Rosmarinus officinalis L.) powder (RP) and vitamin E (VE) at different levels on humoral immunity of broilers during a 42-day production cycle. A total of 270 1-day-old male chicks were assigned to nine groups with three replicates of ten birds each, and diets were supplemented with 0, 0.5, or 1.0% RP and 0, 100, or 200 mg/kg VE, respectively. Commercial-inactivated vaccines against avian influenza (AI) and Newcastle disease (ND) viruses, and living infectious bronchitis virus (IBV) vaccine were administered by spray method...
March 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29325970/the-role-of-adjuvant-immunomodulatory-agents-for-treatment-of-severe-influenza
#20
REVIEW
David S Hui, Nelson Lee, Paul K Chan, John H Beigel
A severe inflammatory immune response with hypercytokinemia occurs in patients hospitalized with severe influenza, such as avian influenza A(H5N1), A(H7N9), and seasonal A(H1N1)pdm09 virus infections. The role of immunomodulatory therapy is unclear as there have been limited published data based on randomized controlled trials (RCTs). Passive immunotherapy such as convalescent plasma and hyperimmune globulin have some studies demonstrating benefit when administered as an adjunctive therapy for severe influenza...
February 2018: Antiviral Research
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