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Immune globulin treatment

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https://www.readbyqxmd.com/read/29231470/-impacts-of-mild-moxibustion-on-immune-indices-and-nailfold-microcirculation-in-the-subhealthy-group
#1
Lu He, Chunhua Wang, Ling Hu, Feng Hao, Zijian Wu, Ronglin Cai, Jie Wang
OBJECTIVE: To compare the difference in the clinical therapeutic effects of the regulation of subhealthy condition between the mild moxibustion on alternate days and Chinese herbal medicine. METHODS: Seventy-two participants of subhealthy condition were assigned into a mild moxibustion group (36 cases) and a medication group (36 cases) according to random number table. In the mild moxibustion group, the intervention of mild moxibustion with moxa stick was applied to Guanyuan (CV 4), Zusanli (ST 36) and Sanyinjiao (SP 6), once every other day...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29229452/efficacy-of-human-botulism-immune-globulin-for-the-treatment-of-infant-botulism-the-first-12-years-post-licensure
#2
Jessica R Payne, Jessica M Khouri, Nicholas P Jewell, Stephen S Arnon
OBJECTIVES: To report the efficacy of Human Botulism Immune Globulin Intravenous (BIG-IV) in the first 12 years following its licensure in 2003 and to characterize its use nationwide in treating patients with infant botulism. STUDY DESIGN: Medical records and billing information were collected for US patients treated with BIG-IV from 2003 to 2015. Length of hospital stay (LOS) and hospital charge information for treated patients were compared with the BIG-IV Pivotal Clinical Trial Placebo Group to quantify decreases in LOS and hospital charges...
December 8, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29187875/prognostic-effect-of-albumin-to-globulin-ratio-in-patients-with-solid-tumors-a-systematic-review-and-meta-analysis
#3
Jiaxi He, Hui Pan, Wenhua Liang, Dakai Xiao, Xuewei Chen, Minzhang Guo, Jianxing He
Background: Albumin and globulin are main components of serum protein. The level of albumin and globulin partially represents the nutrition status and immune system. Albumin-to-globulin ratio (AGR) has been reported as a prognostic factor in various cancers. We therefore performed a meta-analysis to elucidate the prognosis effect of AGR on survival outcomes in solid tumors. Method: Six electronic database were searched for the relevant articles that assessing the prognostic value of pre-treatment AGR in solid tumor patients...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29186076/the-role-of-anti-thymocyte-globulin-or-alemtuzumab-based-serotherapy-in-the-prophylaxis-and-management-of-graft-versus-host-disease
#4
REVIEW
Robert Ali, Jeremy Ramdial, Sandra Algaze, Amer Beitinjaneh
Allogeneic hematopoietic stem cell transplant is an established treatment modality for hematologic and non-hematologic diseases. However, it is associated with acute and long-term sequelae which can translate into mortality. Graft-versus-host disease (GVHD) remains a glaring obstacle, especially with the advent of reduced-intensity conditioning. Serotherapy capitalizes on antibodies which target T cells and other immune cells to mitigate this effect. This article focuses on the utility of two such agents: anti-thymocyte globulin (ATG) and alemtuzumab...
November 29, 2017: Biomedicines
https://www.readbyqxmd.com/read/29183643/selective-targeting-of-pro-inflammatory-th1-cells-by-microrna-148a-specific-antagomirs-in%C3%A2-vivo
#5
Patrick Maschmeyer, Georg Petkau, Francesco Siracusa, Jakob Zimmermann, Franziska Zügel, Anja Andrea Kühl, Katrin Lehmann, Sarah Schimmelpfennig, Melanie Weber, Claudia Haftmann, René Riedel, Markus Bardua, Gitta Anne Heinz, Cam Loan Tran, Bimba Franziska Hoyer, Falk Hiepe, Sebastian Herzog, Jürgen Wittmann, Nikolaus Rajewsky, Fritz Georg Melchers, Hyun-Dong Chang, Andreas Radbruch, Mir-Farzin Mashreghi
In T lymphocytes, expression of miR-148a is induced by T-bet and Twist1, and is specific for pro-inflammatory Th1 cells. In these cells, miR-148a inhibits the expression of the pro-apoptotic protein Bim and promotes their survival. Here we use sequence-specific cholesterol-modified oligonucleotides against miR-148a (antagomir-148a) for the selective elimination of pro-inflammatory Th1 cells in vivo. In the murine model of transfer colitis, antagomir-148a treatment reduced the number of pro-inflammatory Th1 cells in the colon of colitic mice by 50% and inhibited miR-148a expression by 71% in the remaining Th1 cells...
November 25, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29180294/homeopathic-treatment-as-an-alternative-prophylactic-to-minimize-bacterial-infection-and-prevent-neonatal-diarrhea-in-calves
#6
Bruno F Fortuoso, Andreia Volpato, Luana Rampazzo, Patrícia Glombowsky, Luiz Gustavo Griss, Gabriela M Galli, Lenita M Stefani, Matheus D Baldissera, Emanuel B Ferreira, Gustavo Machado, Aleksandro S da Silva
Bovine neonatal diarrhea is common due low immunity in newborn calves, poor management (or absence) of sanitary barriers, and other factors. Newborn calves with diarrhea in the first days of life suffer failure to thrive and may die if left untreated. The aim of this study was to evaluate whether prophylactic administration of a homeopathic product (Dia 100®) can control bovine neonatal diarrhea in calves born on a farm with substantial sanitary challenges. We counted total bacteria and protozoan parasites in fecal samples...
November 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29172399/methylprednisolone-versus-intravenous-immune-globulin-as-an-initial-therapy-in-adult-primary-immune-thrombocytopenia
#7
Chul Hee Kim, Yoon Seok Choi, Ji Young Moon, Duck Yong Kim, So Yeon Lee, Hyo Jin Lee, Hwan Jung Yun, Samyong Kim, Deog Yeon Jo, Ik Chan Song
Background/Aims: Few studies have addressed whether there are differences in clinical efficacy between intravenous methylprednisolone (methyl-Pd) and intravenous immunoglobulin (IVIg) use. Methods: We retrospectively compared platelet responses and toxicities associated with these two treatments in adult patients with immune thrombocytopenia. Patients received intravenous methyl-Pd therapy followed by oral prednisolone (Pd) from 1993 to 2002 and IVIg together with oral Pd from 2003 to 2008...
November 27, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29147612/low-dose-post-transplant-cyclophosphamide-can-mitigate-gvhd-and-enhance-the-g-csf-atg-induced-gvhd-protective-activity-and-improve-haploidentical-transplant-outcomes
#8
Yu Wang, Ying-Jun Chang, Lu Chen, Lan-Ping Xu, Zhi-Lei Bian, Xiao-Hui Zhang, Chen-Hua Yan, Kai-Yan Liu, Xiao-Jun Huang
Use of high-dose, post-transplant cyclophosphamide (PTCy) results in low rates of graft-versus-host-disease (GVHD) and favorable immune reconstitution, although with higher rates of relapse and somewhat high rates of graft failure. We hypothesized that permissible dose reduction of PTCy might be feasible. The current study attempts to establish a murine model and focus on regulatory T cells (Tregs) to clarify the immunological mechanisms for GVHD prevention by low-dose PTCy. In addition, a prospective, clinical cohort study in haploidentical, T-cell replete transplantation is initiated to support the rational...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29062199/immunological-and-histopathological-changes-in-sheep-affected-with-cutaneous-squamous-cell-carcinoma-and-treated-immunotherapeutically
#9
Faten A M Abo-Aziza, A A Zaki, A El-Shemy, Sahar S Abd Elhalem, Amany S Amer
BACKGROUND AND AIM: Recently, it has been recorded unexpected percentage of cutaneous squamous cell carcinoma (cSCC) in sheep. Despite the improvement in surgical treatment, the outcome of animals remains limited by metastatic relapse. Although antibodies for cancer treatment have been practiced for many decades, the use of this methodology in animals is deficient. This study aimed to establish cSCC therapy by tumor cell protein antibody (Ab1) or secondary antibody (Ab2) raised by two series of immunization in the same strain of rabbits...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29058092/anthrax-immune-globulin-improves-hemodynamics-and-survival-during-b-anthracis-toxin-induced-shock-in-canines-receiving-titrated-fluid-and-vasopressor-support
#10
Dante A Suffredini, Xizhong Cui, Dharmvir Jaswal, Kenneth E Remy, Yan Li, Junfeng Sun, Steven B Solomon, Yvonne Fitz, Mahtab Moayeri, Stephen Leppla, Peter Q Eichacker
BACKGROUND: Although anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for B. anthracis toxin-associated shock is unknown. METHODS: We therefore tested AIG in sedated, mechanically ventilated canines challenged with 24-h B. anthracis lethal and edema toxin infusions and supported for 96 h with a previously demonstrated protective regimen of titrated normal saline and norepinephrine...
October 23, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29035131/ri-002-an-intravenous-immunoglobulin-containing-high-titer-neutralizing-antibody-to-rsv-and-other-respiratory-viruses-for-use-in-primary-immunodeficiency-disease-and-other-immune-compromised-populations
#11
Richard L Wasserman, Benjamin N Greener, James Mond
Novel immune globulin (IG) products (RI-002, RI-001) have been designed to provide protection against respiratory syncytial virus (RSV) mediated respiratory illness while at the same time meeting the manufacturing requirements established by FDA for antibody supplementation in immunocompromised subjects. Areas covered: This review covers the manufacture and development of both RI-001 and RI-002, including the selection of plasma donors for IG preparation with high-titers of anti-RSV antibody, in vitro, and preclinical data in the cotton rat model S...
October 16, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28978855/allogeneic-hematopoietic-stem-cell-transplantation-using-atg-prophylaxis-and-treatment
#12
Nobuhiro Nishio, Yoshiyuki Takahashi, Seiji Kojima
Graft versus host disease (GVHD) following allogeneic hematopoietic stem cell transplantation is associated with an increase in patient transplant-related morbidity and mortality and a decrease in quality of life. Adequate immune suppression is critical to prevent GVHD without increasing the risk of developing a severe infection or relapse of malignancy. Anti-T cell globulin (ATG) combined with other immunosuppressive drugs can reduce the risk of severe acute GVHD and extensive chronic GVHD without enhancing the rate of severe infection or relapse of malignancy...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28970002/immunoadsorption-for-collagen-and-rheumatic-diseases
#13
REVIEW
Ken Yamaji
The field of therapeutics has seen remarkable progress in the recent years, which has made mainstream drug treatment possible for collagen and rheumatic diseases. However, treatment of intractable cases where drug effectiveness is poor is a challenge. Furthermore, organ damage, concurrent illnesses or allergic reactions make adequate drug therapy impossible. For such cases, therapeutic apheresis is very significant, and it is important how this should be valued related to drug therapies. Therapeutic apheresis for collagen and rheumatic diseases involves the removal of factors that cause and exacerbate the disease; the aim of immunoadsorption, in particular, is to improve the clinical condition of patients with autoimmune disease by selectively removing pathogenic immune complexes and autoantibodies from their plasma...
August 30, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28948048/effect-of-prunus-armeniaca-seed-extract-on-health-survivability-antioxidant-blood-biochemical-and-immune-status-of-broiler-chickens-at-high-altitude-cold-desert
#14
Sahil Kalia, Vijay K Bharti, Arup Giri, Bhuvnesh Kumar
Extreme climatic conditions and hypobaric hypoxia at high altitude hinders the growth and productivity of chickens. The present study was carried out to examine the effect of aqueous extract of Prunus armeniaca seeds on health, survivability, antioxidants, plasma biochemical parameters, and immune status of broiler chickens at high altitude. Phytochemical analysis of extract revealed the presence of high phenolics, flavonoids, and carotenoids contents. Before the in vivo study, in vitro efficacy evaluation indicated a significant protective effect of the extract in chicken peripheral blood lymphocytes...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28941751/immune-reconstitution-with-two-different-rabbit-polyclonal-anti-thymocytes-globulins
#15
Jamal Bamoulid, Thomas Crepin, Emilie Gaiffe, Caroline Laheurte, Bruno Moulin, Luc Frimat, Philippe Rieu, Christiane Mousson, Antoine Durrbach, Anne-Elisabeth Heng, Jean-Michel Rebibou, Philippe Saas, Cécile Courivaud, Didier Ducloux
Broad T cell depletion by polyclonal anti-thymocyte globulins (ATG) has been used for many years as a part of immunosuppressive treatment in transplantation. Currently, two different ATG are used in clinical practice, Thymoglobulin and Grafalon. Due to differences in the immunization source, these products contain different specificities and quantity of antibodies. These differences may have clinical consequences. We conducted a nested study in a large prospective multicentric cohort of kidney transplant to determine whether Grafalon-treated and Thymoglobulin-treated patients experience different lymphocyte reconstitution and clinical outcomes...
September 20, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28927685/the-prevention-of-coronary-arterial-abnormalities-in-kawasaki-disease-a%C3%A2-meta-analysis-of-the-corticosteroid-effectiveness
#16
Tsung-Ju Yang, Ming-Tai Lin, Chun-Yi Lu, Jong-Min Chen, Ping-Ing Lee, Li-Min Huang, Mei-Hwan Wu, Luan-Yin Chang
OBJECTIVE: The use of corticosteroid in Kawasaki disease (KD) remains controversial among current guidelines. The objective of this study is to summarize the effectiveness and safety of corticosteroid to prevent coronary arterial lesions in Kawasaki disease, both as initial and rescue therapy. METHODS: The Medline, EMBASE, Google scholar, Cochrane Central Register of Controlled Trials databases, ClinicalTrials.gov, and Japanese Institutional Repositories Online were searched for studies up to 31 March 2017...
September 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28892919/plasma-exchange-as-a-therapeutic-modality-in-a-rare-case-of-cryptogenic-new-onset-refractory-status-epilepticus-norse
#17
Manisha Shrivastava, Smita Chouhan, Seema Navaid
Refractory Status Epilepticus (RSE) not responding to any therapy and not associated with any aetiology has been termed as New Onset Refractory Status Epilepticus (NORSE). Guidelines for optimal management of cryptogenic NORSE are not clearly defined so far in the literature. Other than common medication, use of high-dose steroids, IV immune globulins and plasma exchanges in NORSE of unknown aetiology have been scarcely described. Immunomodulatory therapy like plasmapheresis is based on the fact that a pathological substance exists in the plasma that contributes to the disease process and its symptoms, which gets removed...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28864138/comparison-of-different-rabbit-anti-thymocyte-globulin-formulations-in-allogeneic-stem-cell-transplantation-systematic-literature-review-and-network-meta-analysis
#18
Nico Gagelmann, Francis Ayuk, Christine Wolschke, Nicolaus Kröger
Since 2000, various phase III randomized controlled trials (RCTs) have investigated the efficacy of rabbit antithymocyte globulin (ATG) in patients following allogeneic stem cell transplantation (allo-SCT). Comparisons of different ATG formulations are lacking, however. Our aim was to synthesize all published efficacy evidence to enable a comparison of all available formulations of rabbit ATG in the allo-SCT setting. We performed a systematic literature review to identify all available phase III RCT evidence...
August 30, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28851379/prognosis-and-treatment-of-folfox-therapy-related-interstitial-pneumonia-a-plea-for-multimodal-immune-modulating-therapy-in-the-respiratory-insufficient-patient
#19
Annick De Weerdt, Amélie Dendooven, Annemie Snoeckx, Jan Pen, Martin Lammens, Philippe G Jorens
BACKGROUND: The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response rate, duration of response and patient survival, reports of serious toxic pulmonary side effects have progressively emerged. CASE PRESENTATION: We describe a patient who was treated with FOLFOX as an adjuvant to a rectosigmoidal resection of a rectosigmoidal carcinoma and who developed respiratory insufficiency requiring mechanical ventilation...
August 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28830712/effects-of-nanostructured-zeolite-and-aflatoxin-b1-in-growth-performance-immune-parameters-and-pathological-conditions-of-rainbow-trout-oncorhynchus-mykiss
#20
S Alinezhad, M Faridi, B Falahatkar, R Nabizadeh, D Davoodi
The reduction of Aflatoxin B1 (AF) in juvenile rainbow trout (Oncorhynchus mykiss) diet was analyzed after supplementing Nanostructured Zeolite (NZ) in a 56-day experiment. Two hundred and seventy juveniles with an average weight of 23 ± 3.7 g were placed in 6 different groups of C (control as a basal diet), NZ0.5 (basal diet + 0.5% NZ), NZ1 (basal diet + 1% NZ), AF5 (basal diet + 5 mg AFB1), AF5 NZ0.5 (basal diet + 5 mg AFB1 + 0.5% NZ), AF5 NZ1 (basal diet + 5 mg AFB1 + 1% NZ) with three replications and were fed four times a day based on their satiation...
August 19, 2017: Fish & Shellfish Immunology
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