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Immune globulin treatment

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https://www.readbyqxmd.com/read/27913549/second-line-therapies-in-immune-thrombocytopenia
#1
Rachael F Grace, Cindy Neunert
Immune thrombocytopenia (ITP) is a rare, acquired autoimmune condition characterized by a low platelet count and an increased risk of bleeding. Although many children and adults with ITP will not need therapy beyond historic first-line treatments of observation, steroids, intravenous immunoglobulin (IVIG), and anti-D globulin, others will have an indication for second-line treatment. Selecting a second-line therapy depends on the reason for treatment, which can vary from bleeding to implications for health-related quality of life (HRQoL) to likelihood of remission and patient preference with regard to adverse effects, route of administration, and cost...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27817784/-unexpected-cutaneous-purpura-in-an-infant
#2
Yang-Yang Luo, Zhu Wei, Ying-Hong Zeng, Bin Zhou, Jian-Ping Tang
A two-month-old boy visited the hospital due to unexpected cutaneous purpura and thrombocytopenia for 2 days. The physical examination revealed a purple mass on the back. The soft tissue color Doppler ultrasound showed rich blood signals in the tissue, and the results of bone marrow puncture indicated an increased number of megakaryocytes. After the treatment with hormone and gamma globulin, the platelet count rapidly increased and maintained at a normal level. Meanwhile, the boy was given oral administration of propranolol...
November 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27807853/aseptic-meningitis-following-therapy-with-immune-globulins-a-combination-of-product-features-and-patient-characteristics
#3
Roger Berg, Elisabeth Fuellenhals
BACKGROUND: Aseptic meningitis (AM) represents a recognized side effect of immune globulin (IG) therapy and may warrant additional diagnostic procedures and therapy with anti-infective drugs until a definite diagnosis can be established. Although, to date, only small case series have been published, the objective of the current study was to investigate a large case series of patients with AM. STUDY DESIGN AND METHODS: The pharmacovigilance safety database of a 10% liquid IG (Gammagard Liquid) was queried for all reports of AM...
November 2, 2016: Transfusion
https://www.readbyqxmd.com/read/27801824/rabies-control-and-treatment-from-prophylaxis-to-strategies-with-curative-potential
#4
REVIEW
Shimao Zhu, Caiping Guo
Rabies is an acute, fatal, neurological disease that affects almost all kinds of mammals. Vaccination (using an inactivated rabies vaccine), combined with administration of rabies immune globulin, is the only approved, effective method for post-exposure prophylaxis against rabies in humans. In the search for novel rabies control and treatment strategies, live-attenuated viruses have recently emerged as a practical and promising approach for immunizing and controlling rabies. Unlike the conventional, inactivated rabies vaccine, live-attenuated viruses are genetically modified viruses that are able to replicate in an inoculated recipient without causing adverse effects, while still eliciting robust and effective immune responses against rabies virus infection...
October 28, 2016: Viruses
https://www.readbyqxmd.com/read/27779572/age-and-early-graft-function-relate-with-risk-benefit-ratio-of-allogenic-islet-transplantation-under-anti-thymocyte-globulin-mycophenolate-mofetil-tacrolimus-immune-suppression
#5
Da Hae Lee, Bart Keymeulen, Robert Hilbrands, Zhidong Ling, Ursule Van de Velde, Daniel Jacobs-Tulleneers-Thevissen, Geert Maleux, Bruno Lapauw, Laurent Crenier, Christophe De Block, Chantal Mathieu, Daniel Pipeleers, Pieter Gillard
BACKGROUND: Induction therapy with a T cell depleting agent followed by mycophenolate mofetil (MMF) and tacrolimus (Tac) is presently the most frequently used immune suppression (IS) regimen in islet transplantation. This study assesses its safety and tolerability in nonuremic type 1 diabetic recipients. METHODS: Fifty-one patients (ages between 29-63 years) with high glycemic variability and problematic hypoglycemia received intraportal islet grafts under anti-thymocyte globulin (ATG)-MMF-Tac protocol...
October 25, 2016: Transplantation
https://www.readbyqxmd.com/read/27735024/the-effect-of-immunoglobulin-treatment-for-hemolysis-on-the-incidence-of-necrotizing-enterocolitis-a-meta-analysis
#6
Y Yang, J-J Pan, X-G Zhou, X-Y Zhou, R Cheng, Y-H Hu
OBJECTIVE: The application of intravenous immune globulin (IVIG) has been recommended for treating hemolysis in neonates for several years. But in clinical work, more than one study reported that IVIG treatment maybe increased the risk of NEC in hemolytic patients. In light of this situation, we performed this meta-analysis. MATERIALS AND METHODS: We searched in PubMed, Embase, Cochrane databases for English references, and in Wanfang, VIP, Cnki databases for Chinese references (all last launched on 2015/12/18)...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27692322/tlr-2-and-tlr-4-transcriptions-in-unstimulated-blood-from-dogs-with-leishmaniosis-due-to-leishmania-infantum-at-the-time-of-diagnosis-and-during-follow-up-treatment
#7
Sara Montserrat-Sangrà, Lorena Alborch, Laura Ordeix, Laia Solano-Gallego
Innate immunity, in particular, the role of toll-like receptors (TLRs), has not been extensively studied in canine L. infantum infection. The main aim of this study was to determine the transcription of TLR2 and TLR4 in the blood of dogs with natural clinical leishmaniosis at the time of diagnosis and during treatment follow-up and subsequently correlate these findings with clinical, serological and parasitological data. Forty-six Leishmania-seropositive sick dogs with a high antibody level at the time of diagnosis were studied and compared with 34 healthy seronegative dogs...
September 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27681743/the-clinical-diagnosis-and-management-of-kawasaki-disease-a-review-and-update
#8
REVIEW
Frank H Zhu, Jocelyn Y Ang
Kawasaki disease is an acute, self-limited vasculitis of childhood and has become the leading cause of acquired pediatric heart disease in the USA. Prompt treatment is essential in reducing cardiac-related morbidity and mortality. The underlying etiology remains unknown. The disease itself may be the characteristic manifestation of a common pathway of immune-mediated vascular inflammation in susceptible hosts. The characteristic clinical features of fever for at least 5 days with bilateral nonpurulent conjunctivitis, rash, changes in lips and oral cavity, changes in peripheral extremities, and cervical lymphadenopathy remain the mainstay of diagnosis...
September 2016: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/27677760/serum-igg-levels-and-mortality-in-patients-with-severe-sepsis-and-septic-shock-the-sbits-data
#9
S Dietz, C Lautenschläger, U Müller-Werdan, G Pilz, P Fraunberger, M Päsler, H Ebelt, A K Walli, K Werdan, S Nuding
BACKGROUND: The role of intravenous immune globulin (Ig) therapy in patients with severe sepsis and septic shock is discussed controversially. Low initial IgG levels could help to identify those patients who might benefit from an adjunctive Ig treatment. OBJECTIVES: To investigate the effect of initial serum IgG levels on 28-day mortality in patients with severe sepsis and septic shock. MATERIALS AND METHODS: In this retrospective analysis of the SBITS trial data, 543 patients were allocated to four groups (quartiles) depending on their initial serum IgG levels (1: IgG ≤ 6...
September 27, 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/27670085/feeding-pyridoxine-prevents-saprolegnia-parasitica-infection-in-fish-labeo-rohita
#10
Himadri Saha, Asim Kumar Pal, Narottam Prasad Sahu, Ratan Kumar Saha
A 60-day experiment was carried out to delineate the role of dietary pyridoxine (DP) in Labeo rohita fingerlings in modulating immunity and prevention of fungal infection. Two hundred and seventy fingerlings were randomly distributed into three treatments in triplicates. Three iso-caloric and iso-nitrogenous purified diets were prepared with graded levels of pyridoxine. Three experimental groups were C (0.0% DP), T1 (0.01% DP) and T2 (0.02% DP). The role of dietary pyridoxine in modulating immunity and prevention of fungal infection was assessed by haemato-immunological parameters like erythrocyte counts (EC), leucocyte counts (LC), haemoglobulin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), nitro-blue tetrazolium (NBT), phagocytic activity, albumin, globulin, total plasma protein, albumin/globulin and by challenge study with Saprolegnia parasitica, where relative percentage survival (RPS) were recorded...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27666192/effects-of-medicinal-herbs-plantago-asiatica-houttuynia-cordata-and-mentha-haplocalyx-on-non-specific-immune-responses-of-cobia-rachycentron-canadum
#11
Yu-Sheng Wu, Yin-Yu Chen, Pien-Sheng Ueng, Fan-Hua Nan
This study investigated the effects of orally administered Plantago asiatica, Houttuynia cordata, and Mentha haplocalyx on the growth and nonspecific immune responses of cobia (Rachycentron canadum). The nonspecific immune parameters assessed were weight gain, feed conversion ratio, superoxide anion (O2(-)) production, superoxide dismutase (SOD) activity, phagocytic rate, phagocytic index, lysozyme activity, serum albumin and globulin, and albumin:globulin (A/G) ratio. The growth experiment indicated that 6-week dietary treatments did not significantly affect on the growth of cobia...
September 22, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27646125/changes-in-serum-proteins-after-endotoxin-administration-in-healthy-and-choline-treated-calves
#12
Z Yilmaz, O Eralp Inan, M Kocaturk, A T Baykal, O Hacariz, I Hatipoglu, A Tvarijonaviciute, M Cansev, J Ceron, I H Ulus
BACKGROUND: This study aimed to investigate the possible serum protein changes after endotoxin administration in healthy and choline-treated calves using proteomics. These results are expected to contribute to the understanding of the pathophysiological mechanisms of endotoxemia and the beneficial effect of choline administration in this clinical situation. METHODS: Healthy-calves (n = 20) were divided into 4 groups: Control, Choline treated (C), Lipopolysaccharide administered (LPS), and LPS + C...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27623619/treatment-with-high-dose-recombinant-human-hyaluronidase-facilitated-subcutaneous-immune-globulins-in-patients-with-juvenile-dermatomyositis-who-are-intolerant-to-intravenous-immune-globulins-a-report-of-5-cases
#13
Fabian Speth, Johannes-Peter Haas, Claas H Hinze
BACKGROUND: High-dose intravenous immune globulins (IVIg) are frequently used in refractory juvenile dermatomyositis (JDM) but are often poorly tolerated. High-dose recombinant human hyaluronidase-facilitated subcutaneous immune globulins (fSCIg) allow the administration of much higher doses of immune globulins than conventional subcutaneous immune globulin therapy and may be an alternative to IVIg. The safety and efficacy of fSCIg therapy in JDM is unknown. CASE PRESENTATION: In this retrospective case series, five patients with steroid-refractory severe JDM were treated with high-dose fSCIg due to IVIg adverse effects (severe headaches, nausea, vomiting, difficult venous access)...
2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27613250/efficacy-safety-tolerability-and-pharmacokinetics-of-a-novel-human-immune-globulin-subcutaneous-20-a-phase-2-3-study-in-europe-in-patients-with-primary-immunodeficiencies
#14
M Borte, G Kriván, B Derfalvi, L Maródi, T Harrer, S Jolles, C Bourgeois, W Engl, H Leibl, B McCoy, D Gelmont, L Yel
A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospective trial in Europe in 49 patients with PIDD aged 2-67 years. Over a median of 358 days, patients received 2349 IGSC 20% infusions at monthly doses equivalent to those administered for previous intravenous or subcutaneous IgG treatment...
September 10, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27608635/nutrient-intake-digestibility-and-performance-of-gaddi-kids-supplemented-with-tea-seed-or-tea-seed-saponin-extract
#15
Manjeet Kumar, Alagarsamy Kannan, Rasbehari Bhar, Ashu Gulati, Alok Gaurav, Vijay Kumar Sharma
The present study determined the nutrient intake, digestibility, nitrogen balance, microbial protein synthesis, haemato-biochemical attributes, immune response and growth performance of Gaddi kids fed with oat fodder based basal diet supplemented with either tea seed or tea seed saponin extract. Eighteen male kids, 7.03 ± 0.16 months of age and 19.72 ± 0.64 kg body weight (BW) , were distributed into three groups, T0 (control), T1 and T2, consisting of 6 animals each in a completely randomised design. The kids were fed a basal diet consisting of concentrate mixture and oat fodder (50:50) to meet the maintenance requirement and for growth rate of 40 g/day...
September 9, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27606347/paraneoplastic-cerebellar-degeneration-with-anti-yo-antibodies-a-review
#16
REVIEW
Anand Venkatraman, Puneet Opal
The ataxic syndrome associated with Anti-Yo antibody, or Purkinje cell cytoplasmic antibody type 1 (PCA1), is the most common variant of paraneoplastic cerebellar degeneration (PCD). The typical presentation involves the subacute development of pancerebellar deficits with a clinical plateau within 6 months. The vast majority of cases have been reported in women with pelvic or breast tumors. Magnetic resonance imaging of the brain is often normal in the early stages, with cerebellar atrophy seen later. The underlying mechanism is believed to be an immunological reaction to cerebellar degeneration-related protein 2 (CDR2), a protein usually found in the cerebellum that is ectopically produced by tumor cells...
August 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/27585863/seroprevalence-and-risk-factors-of-toxoplasma-gondii-infection-in-pregnant-women-following-antenatal-care-at-mizan-aman-general-hospital-bench-maji-zone-bmz-ethiopia
#17
Fira Abamecha, Hasen Awel
BACKGROUND: The intracellular parasite, Toxoplasma gondii (T.gondii) is found worldwide. Infection with T. gondii during pregnancy can result in fetal and neonatal death or various congenital defects. A serological survey during pregnancy represents a valuable tool for the effective diagnosis and treatment of infected neonates. The aim of this study was to assess the sero-prevalence and risk factors of T.gondii in pregnant women following ante natal care (ANC) services at Mizan Aman General Hospital, Bench Maji zone (BMZ), Ethiopia...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27582171/efficacy-safety-and-pharmacokinetics-of-a-novel-human-immune-globulin-subcutaneous-20%C3%A2-in-patients-with-primary-immunodeficiency-diseases-in-north-america
#18
Daniel Suez, Mark Stein, Sudhir Gupta, Iftikhar Hussain, Isaac Melamed, Kenneth Paris, Amy Darter, Christelle Bourgeois, Sandor Fritsch, Heinz Leibl, Barbara McCoy, David Gelmont, Leman Yel
Patients with primary immunodeficiency disease (PIDD) typically require life-long intravenous (IV) or subcutaneous (SC) immunoglobulin (Ig) replacement therapy to prevent recurrent infections. The efficacy, safety, and pharmacokinetics of a highly concentrated (20 %) Ig preparation for SC administration (IGSC 20 %) were evaluated in a prospective trial in patients with PIDD. A total of 74 patients (aged 3-83 years) received 4327 IGSC 20 % infusions over a median of 380.5 days. The rate of validated serious bacterial infections was 0...
October 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27563813/potent-in-vitro-and-in-vivo-effects-of-polyclonal-anti-human-myeloma-globulins
#19
Aneta Schieferdecker, Ofer Shoshani, Benedikt Westner, Dov Zipori, Boris Fehse, Nicolaus Kröger, Francis Ayuk
INTRODUCTION: Multiple myeloma is still incurable in most cases. Polyclonal anti T lymphocyte globulins (ATG) have been reported to kill human myeloma cells in vitro and in mouse models. METHODS: Anti-human-myeloma globulins (AMG) were produced by immunizing rabbits with human myeloma cell lines RPMI-8226 (AMG-8226) or KMS-12-BM (AMG-12-BM). Cytotoxicity of the polyclonal antibodies was analyzed in vitro and in a xenograft NOD-SCID mouse model. RESULTS: Both AMG had stronger cytotoxicity against myeloma cells compared to ATG...
August 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27483431/post-exposure-treatment-with-anti-rabies-vhh-and-vaccine-significantly-improves-protection-of-mice-from-lethal-rabies-infection
#20
Sanne Terryn, Aurélie Francart, Heidi Rommelaere, Catelijne Stortelers, Steven Van Gucht
Post-exposure prophylaxis (PEP) against rabies infection consists of a combination of passive immunisation with plasma-derived human or equine immune globulins and active immunisation with vaccine delivered shortly after exposure. Since anti-rabies immune globulins are expensive and scarce, there is a need for cheaper alternatives that can be produced more consistently. Previously, we generated potent virus-neutralising VHH, also called Nanobodies, against the rabies glycoprotein that are effectively preventing lethal disease in an in vivo mouse model...
August 2016: PLoS Neglected Tropical Diseases
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