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https://www.readbyqxmd.com/read/29777608/osteocalcin-value-to-identify-subclinical-atherosclerosis-over-atherosclerotic-cardiovascular-disease-ascvd-risk-score-in-middle-aged-and-elderly-chinese-asymptomatic-men
#1
Yiting Xu, Xiaojing Ma, Qin Xiong, Xueli Zhang, Yun Shen, Yuqian Bao
BACKGROUND: Our study examined whether osteocalcin contributed to identifying carotid intima-media thickness (C-IMT) over the atherosclerotic cardiovascular disease (ASCVD) risk score. METHODS: We recruited 618 middle-aged and elderly men from communities in Shanghai. Serum osteocalcin levels were determined using an electrochemiluminescence immunoassay. C-IMT was measured by ultrasonography. RESULTS: The study included 245 men with low ASCVD risk and 373 men with moderate-to-high ASCVD risk...
May 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29773421/r46l-polymorphism-in-the-pcsk9-gene-relationship-to-lipid-levels-subclinical-vascular-disease-and-erectile-dysfunction
#2
Jose M Mostaza, Carlos Lahoz, Miguel A Salinero-Fort, Olaya de Dios, Elisa Castillo, Teresa González-Alegre, Francisca García-Iglesias, Eva Estirado, Fernando Laguna, Concesa Sabín, Silvia López, Victor Cornejo, Carmen de Burgos, Vanesa Sanchez, Carmen Garcés
BACKGROUND: The R46L variant of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has been related to lipid levels and cardiovascular disease. OBJECTIVE: To evaluate the influence of this polymorphism on subclinical vascular disease and erectile dysfunction (ED). METHODS: We analyzed the association of the PCSK9 rs11591147 single-nucleotide polymorphism with lipid levels, intima-media thickness (IMT), and the ankle-brachial index, in 1188 adults free of cardiovascular disease, randomly selected from the population...
April 21, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29770339/red-blood-cell-distribution-width-is-associated-with-carotid-atherosclerosis-in-people-with-type-2-diabetes
#3
J S Nam, C W Ahn, S Kang, K R Kim, J S Park
Aims: Red cell distribution width (RDW) has been shown to be associated with cardiovascular diseases (CVD). The relationship between RDW and carotid intima-media thickness (C-IMT), a marker of subclinical atherosclerosis, has been inconsistent in subjects with cardiovascular risk factors. In this study, we investigated the relationship between RDW and carotid atherosclerosis in people with type 2 diabetes. Methods: Four hundred sixty-nine people with type 2 diabetes without history of cardiovascular or cerebrovascular diseases were enrolled...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29767544/the-aerobic-resistance-inspiratory-muscle-training-hypothesis-in-heart-failure
#4
Ioannis D Laoutaris
Evidence from large multicentre exercise intervention trials in heart failure patients, investigating both moderate continuous aerobic training and high intensity interval training, indicates that the 'crème de la crème' exercise programme for this population remains to be found. The 'aerobic/resistance/inspiratory (ARIS) muscle training hypothesis in heart failure' is introduced, suggesting that combined ARIS muscle training may result in maximal exercise pathophysiological and functional benefits in heart failure patients...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29763709/fenofibrate-effects-on-carotid-artery-intima-media-thickness-in-adults-with-type-2-diabetes-mellitus-a-field-substudy
#5
Jason A Harmer, Anthony C Keech, Anne-Sophie Veillard, Michael R Skilton, Gerald F Watts, David S Celermajer
AIM: Dyslipidemia in type 2 diabetes contributes to an increased risk of cardiovascular disease. Fenofibrate, a lipid-regulating peroxisome proliferator-activated receptor-α (PPARα) agonist, has been shown to reduce vascular complications in adults with type 2 diabetes. The mechanisms for such benefit, however, are not yet well understood. We examined the effects of fenofibrate on carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in adults with type 2 diabetes...
May 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29761089/association-of-haemodynamic-indices-of-central-and-peripheral-pressure-with-subclinical-target-organ-damage
#6
Junli Zuo, Shaoli Chu, Isabella Tan, Mark Butlin, Jiehui Zhao, Alberto Avolio
Background: Central aortic pressure has often been shown to be more closely associated with markers of vascular function and incidence of cardiovascular events compared to peripheral pressure. However, the potential clinical use of central aortic or peripheral haemodynamic indices as markers of target organ damage (TOD) has not been fully established. Methods: We evaluated associations of TOD with central aortic and peripheral haemodynamic indices (central aortic [cPP] and peripheral pulse pressure [pPP], central aortic augmentation index, and central and peripheral waveform factor) in 770 hospital inpatients (age 60 ± 10 years, 473 males) with primary hypertension...
March 2018: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/29760679/hematocrit-values-predict-carotid-intimal-media-thickness-in-obese-patients-with-non-alcoholic-fatty-liver-disease-a-cross-sectional-study
#7
Giovanni Tarantino, Luigi Barrea, Domenico Capone, Vincenzo Citro, Teresa Mosca, Silvia Savastano
Background: Literature data suggest with some criticism that full-fledged cardiovascular (CV) events (acute or chronic) are likely predicted by blood components, which are reported to be associated with the presence/severity of non-alcoholic fatty liver disease (NAFLD). This study was aimed at determining which marker(s) derived from blood count, such as white blood cells, neutrophils, neutrophil/lymphocyte ratio, platelet count, hemoglobin, mean corpuscular volume, hematocrit values were associated with ear or subclinical atherosclerosis, in obese patients of various classes suffering from NAFLD...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29758320/neoadjuvant-crizotinib-in-alk-rearranged-inflammatory-myofibroblastic-tumor-of-the-urinary-bladder-a-case-report
#8
Yoshiyuki Nagumo, Aiko Maejima, Yuta Toyoshima, Motokiyo Komiyama, Kan Yonemori, Akihiko Yoshida, Hiroyuki Fujimoto
INTRODUCTION: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that involves various organs, but has a predilection for the urinary bladder in the genitourinary tract. Given that approximately half of all IMT cases have anaplastic lymphoma kinase (ALK) rearrangements, the ALK inhibitor crizotinib is suggested as a promising treatment for unresectable cases. No reports on neoadjuvant crizotinib therapy for locally advanced IMT of the bladder are available. PRESENTATION OF CASE: We report a case of a 17-year-old Japanese boy referred to our institution for painful urination and increased urinary frequency...
May 1, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29757253/association-of-cardiovascular-health-with-epicardial-adipose-tissue-and-intima-media-thickness-the-kardiovize-study
#9
Jana Hruskova, Andrea Maugeri, Helena Podroužková, Tatiana Štípalová, Juraj Jakubík, Martina Barchitta, Jose R Medina-Inojosa, Martin Homolka, Antonella Agodi, Sarka Kunzova, Ondrej Sochor, Francisco Lopez-Jimenez, Manlio Vinciguerra
Background: Intima-media thickness (IMT) has been proposed as a measurement of subclinical atherosclerosis and has been associated with cardiovascular disease (CVD). Epicardial adipose tissue (EAT) is a fat depot between the pericardium and myocardium and has been associated with coronary atherosclerosis. The relationship between IMT and EAT thickness has not been reported before. We investigated the relationship between EAT thickness, IMT, CVD risk factors, and ideal cardiovascular health (CVH) metrics using subjects from the Kardiovize Brno 2030 cohort study, a random urban sample population in Central Europe...
May 13, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29755269/inflammatory-myofibroblastic-tumor-of-the-orbit-a-clinico-pathological-study-of-25-cases
#10
Diego Strianese, Fausto Tranfa, Marialuisa Finelli, Adriana Iuliano, Stefania Staibano, Giuseppe Mariniello
Background: Inflammatory myofibroblastic tumor (IMT) is a rare entity characterized by the presence of myofibroblasts and inflammatory cells within a fibrous stroma, which typically occurs in children or young adults. The IMT is considered generally a benign lesion, although about 20% of cases may experience recurrence, and most rarely develop metastasis. Herein, we present the largest series of primary orbital IMT ever reported. Patients and methods: The clinical records of 25 patients, collected between the 1995 and 2015, with biopsy-proven diagnosis of orbital IMT were retrospectively reviewed to determine demographic, clinical, radiologic and pathological features, management, and outcome...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29748187/complete-and-partial-lcat-deficiency-are-differentially-associated-with-atherosclerosis
#11
Federico Oldoni, Damiano Baldassarre, Samuala Castelnuovo, Alice Ossoli, Mauro Amato, Julian van Capelleveen, G Kees Hovingh, Eric de Groot, Andrea Bochem, Sara Simonelli, Simone Barbieri, Fabrizio Veglia, Guido Franceschini, Jan Albert Kuivenhoven, Adriaan G Holleboom, Laura Calabresi
Background -Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear since mutations in LCAT causing Fish-Eye Disease (FED) or Familial LCAT Deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein (apo) A-I (FED) or on both apoA-I and apoB-containing lipoproteins (FLD), an aspect that has thus far not been investigated...
May 10, 2018: Circulation
https://www.readbyqxmd.com/read/29747638/relations-of-lipid-parameters-other-variables-with-carotid-intima-media-thickness-and-plaque-in-the-general-chinese-adults-an-observational-study
#12
Qingtao Hou, Sheyu Li, Yun Gao, Haoming Tian
BACKGROUND: It has been reported that non-high-density lipoprotein cholesterol (non-HDL-C) and lipid ratios, including total cholesterol (TC) / high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) / HDL-C, are better predictors for atherosclerosis than conventional lipid profiles. However, there have been few studies comparing the predictive values of different lipid parameters for early atherosclerosis. The aim of this study was to determine the relevant factors of carotid intima-media thickness (IMT) and plaque in the general Chinese adults and analyze the predictive values of different lipid parameters for carotid IMT and plaque...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29747013/relationship-between-high-sodium-and-low-pufa-intake-and-carotid-atherosclerosis-in-elderly-women
#13
Elisa Mazza, Yvelise Ferro, Theodora Lamprinoudi, Carmine Gazzaruso, Patrizia Doldo, Arturo Pujia, Tiziana Montalcini
Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women...
May 7, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29743904/intima-media-thickness-and-ankle-brachial-index-are-correlated-with-the-extent-of-coronary-artery-disease-measured-by-the-syntax-score
#14
Krzysztof L Bryniarski, Tomasz Tokarek, Tomasz Bryk, Joanna Rutka, Iwona Gawlik, Anna Żabówka, Grzegorz Dębski, Beata Bobrowska, Krzysztof Żmudka, Artur Dziewierz, Zbigniew Siudak, Dariusz Dudek
Introduction: The extent of peripheral artery disease (PAD) measured by the ankle-brachial index (ABI) and intima-media thickness (IMT) is correlated with the complexity of coronary artery disease (CAD) in stable angina patients. However, data regarding patients with acute coronary syndromes are still lacking. Aim: To compare coronary complexity measured by the SYNTAX score in patients with and without PAD presenting with myocardial infarction (MI). Material and methods: Both ABI and IMT were measured in 101 consecutive patients who underwent primary diagnostic due to MI...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29741228/sle-patients-show-an-increased-arterial-stiffness-that-is-predicted-by-igm-anti-%C3%A3-2-glycoprotein-i-and-small-dense-hdl-particles
#15
Sandra Parra, Miguel Lopez-Dupla, Daiana Ibarretxe, Mercedes de Las Heras, Nuria Amigó, Alba Català, Marc Benavent, Esperanza Garcés, Alvaro Navarro, Antoni Castro
BACKGROUND: Patients with systemic lupus erythematous (SLE) show increased cardiovascular mortality and morbidity. The accelerated atherosclerosis observed in SLE patients has been measured by the carotid intima media thickness (c-IMT) and functional vascular tests, such as the arterial stiffness that occurs before plaque formation. AIMS: To investigate the metabolic and immunological factors associated with the presence of central arterial stiffness measured by the augmentation index (AIx)...
May 9, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29740075/preclinical-outcomes-of-intratumoral-modulation-therapy-for-glioblastoma
#16
Andrea R Di Sebastiano, Andrew Deweyert, Simon Benoit, Erin Iredale, Hu Xu, Cleusa De Oliveira, Eugene Wong, Susanne Schmid, Matthew O Hebb
Glioblastoma (GBM) is the leading cause of high fatality cancer arising within the adult brain. Electrotherapeutic approaches offer new promise for GBM treatment by exploiting innate vulnerabilities of cancer cells to low intensity electric fields. This report describes the preclinical outcomes of a novel electrotherapeutic strategy called Intratumoral Modulation Therapy (IMT) that uses an implanted stimulation system to deliver sustained, titratable, low intensity electric fields directly across GBM-affected brain regions...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740051/the-polymorphism-rs6918289-located-in-the-downstream-region-of-the-trem2-gene-is-associated-with-tnf-%C3%AE-levels-and-imt-f
#17
Vesna Gorenjak, Alex-Ander Aldasoro Arguinano, Sébastien Dadé, Maria G Stathopoulou, Dwaine R Vance, Christine Masson, Sophie Visvikis-Siest
Triggering receptor expressed on myeloid cells 2 (TREM2) is known for its anti-inflammatory properties during the immune response, and influences negatively on TNF-α expression levels. Genetic epidemiology studies have identified polymorphisms located in the TREM2 gene associated with neurodegenerative and chronic inflammatory diseases. TREM2 levels have been observed to affect plasma levels of TNF-α and plaque stability in symptomatic and asymptomatic patients with carotid stenosis. In this study, we investigated polymorphisms located in the TREM2 gene region and association with TNF-α levels and the intima media thickness of the femoral artery...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739898/eml4-alk-rearrangement-and-its-therapeutic-implications-in-inflammatory-myofibroblastic-tumors
#18
Fernando Vargas-Madueno, Edwin Gould, Raul Valor, Nhu Ngo, Linsheng Zhang, Miguel A Villalona-Calero
With the advent of precision medicine, medical oncology is undergoing a transcendental change. These molecular studies have allowed us to learn about potential targeted therapies for patients with advanced cancers. Perhaps the best-known example of success in precision medicine is chronic myeloid leukemia and its response to tyrosine kinase inhibitors targeting the BCR-ABL kinase. Since that original discovery, the role of molecular therapeutics has expanded, and it now presents us with treatment options for common malignancies and rare atypical tumors...
May 8, 2018: Oncologist
https://www.readbyqxmd.com/read/29737302/drug-effect-of-atorvastatin-on-middle-cerebral-atherosclerotic-stenosis-and-high-resolution-nmr-diagnosis
#19
Xingchi Chen, Sainan Wang, Lulu Lin, Yu Li, Hui Zhang
Atherosclerosis (AS) is a chronic inflammatory reaction with the pathological changes in the lipid deposition of arterial intima. The disorder of blood lipid metabolism is the main factor of the occurrence and development of AS, and the inflammatory reaction and autoimmune reaction also run through the development of AS. In this study, we compared the efficacy and safety of atorvastatin, simvastatin, pravastatin and rosuvastatin in the treatment of AS. At the same time, we used high resolution magnetic resonance imaging (MRI) to assess the changes in plaque area in the middle cerebral artery and the patch area before and after drug treatment...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735469/drug-effect-of-atorvastatin-on-middle-cerebral-atherosclerotic-stenosis-and-high-resolution-nmr-diagnosis
#20
Xingchi Chen, Sainan Wang, Lulu Lin, Yu Li, Hui Zhang
Atherosclerosis (AS) is a chronic inflammatory reaction with the pathological changes in the lipid deposition of arterial intima. The disorder of blood lipid metabolism is the main factor of the occurrence and development of AS, and the inflammatory reaction and autoimmune reaction also run through the development of AS. In this study, we compared the efficacy and safety of atorvastatin, simvastatin, pravastatin and rosuvastatin in the treatment of AS. At the same time, we used high resolution magnetic resonance imaging (MRI) to assess the changes in plaque area in the middle cerebral artery and the patch area before and after drug treatment...
May 2018: Pakistan Journal of Pharmaceutical Sciences
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