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https://www.readbyqxmd.com/read/28230491/subcellular-localization-of-m-tuberculosis-in-vivo-and-effect-of-the-adaptive-immunity
#1
Maaike van Zon, Karin de Punder, Astrid van der Sar, Roland Brosch, Rogelio Hernandez Pando, Anita Grootemaat, Wikky Tigchelaar-Gutter, Nicole van der Wel
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28228228/molecular-hybridization-conceded-exceptionally-potent-quinolinyl-oxadiazole-hybrids-through-phenyl-linked-thiosemicarbazide-antileishmanial-scaffolds-in-silico-validation-and-sar-studies
#2
Muhammad Taha, Nor Hadiani Ismail, Muhammad Ali, Umer Rashid, Syarul Imran, Nizam Uddin, Khalid Mohammed Khan
The high potential of quinoline containing natural products and their derivatives in medicinal chemistry led us to discover a novel series of compounds 6-23 based on the concept of molecular hybridization. Most of the synthesized analogues exhibited potent leishmanicidal potential. The most potent compound (23, IC50=0.10±0.001μM) among the series was found ∼70 times more lethal than the standard drug. The current series 6-23 conceded in the development of fourteen (14) extraordinarily active compounds against leishmaniasis...
February 19, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28227586/inductive-power-transmission-to-millimeter-sized-biomedical-implants-using-printed-spiral-coils
#3
Ahmed Ibrahim, Mehdi Kiani, Ahmed Ibrahim, Mehdi Kiani, Ahmed Ibrahim, Mehdi Kiani
The operation frequency (f) has been a key parameter in optimizing wireless power transmission links for biomedical implants with millimeter (mm) dimensions. This paper studies the feasibility of using printed spiral coils (PSCs) for powering mm-sized implants with high power transmission efficiency (PTE) at different fps. Compared to wire-wound coils (WWCs), using a PSC in the implant side allows batch fabrication on rigid or flexible substrates, which can also be used as a platform for integrating implant components...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226730/rf-induced-energy-for-partially-implanted-catheters-a-computational-study
#4
Elena Lucano, Micaela Liberti, Tom Lloyd, Francesca Apollonio, Steve Wedan, Wolfgang Kainz, Leonardo M Angelone, Elena Lucano, Micaela Liberti, Tom Lloyd, Francesca Apollonio, Steve Wedan, Wolfgang Kainz, Leonardo M Angelone, Elena Lucano, Leonardo M Angelone, Tom Lloyd, Steve Wedan, Francesca Apollonio, Wolfgang Kainz, Micaela Liberti
Magnetic Resonance Imaging (MRI) is a radiological imaging technique widely used in clinical practice. MRI has been proposed to guide the catheters for interventional procedures, such as cardiac ablation. However, there are risks associated with this procedure, such as RF-induced heating of tissue near the catheters. The aim of this study is to develop a quantitative RF-safety method for patients with partially implanted leads at 64 MHz. RF-induced heating is related to the electric field incident along the catheter, which in turns depends on several variables, including the position of the RF feeding sources and the orientation of the polarization, which are however often unknown...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226683/preliminary-imaging-results-and-sar-analysis-of-a-microwave-imaging-system-for-early-breast-cancer-detection
#5
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ali Molaei, Ashkan Ghanbarzadeh Dagheyan, Jose Martinez-Lorenzo, Richard Obermeier
Currently X-ray-based imaging systems suffer from low contrast between malignant and healthy fibrous tissues in breast. Microwave Near-field Radar Imaging (NRI) shows a higher contrast between the aforementioned tissues and therefore can enhance tumor detection and diagnosis accuracy. In this work, we present the first imaging results of our developed NRI system that is equipped with a pair of Antipodal Vivaldi Antennas. We used a metal bearing ball immersed in oil as our object of interest, to keep the first measurement configuration simple...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225301/book-reviewlifting-the-impenetrable-veil-from-yellow-fever-to-ebola-hemorrhagic-fever-and-sars-charles-h-calisher-rock-pile-press-red-feather-lakes-colorado-2013-540-pp-isbn-13-978-0-615-82773-5-35-00
#6
https://www.readbyqxmd.com/read/28225197/prediction-on-dielectric-strength-and-boiling-point-of-gaseous-molecules-for-replacement-of-sf6
#7
Xiaojuan Yu, Hua Hou, Baoshan Wang
Developing the environment-friendly insulation gases to replace sulfur hexafluoride (SF6 ) has attracted considerable experimental and theoretical attentions but without success. A computational methodology was presented herein for prediction on dielectric strength and boiling point of arbitrary gaseous molecules in the purpose of molecular design and screening. New structure-activity relationship (SAR) models have been established by combining the density-dependent properties of the electrostatic potential surface, including surface area and the statistical variance of the surface potentials, with the molecular properties including polarizability, electronegativity, and hardness...
April 15, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28224459/effect-of-hallucinogens-on-unconditioned-behavior
#8
Adam L Halberstadt, Mark A Geyer
Because of the ethical and regulatory hurdles associated with human studies, much of what is known about the psychopharmacology of hallucinogens has been derived from animal models. However, developing reliable animal models has proven to be a challenging task due to the complexity and variability of hallucinogen effects in humans. This chapter focuses on three animal models that are frequently used to test the effects of hallucinogens on unconditioned behavior: head twitch response (HTR), prepulse inhibition of startle (PPI), and exploratory behavior...
February 22, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28222318/design-synthesis-biological-evaluation-and-molecular-modeling-study-of-novel-macrocyclic-bisbibenzyl-analogues-as-antitubulin-agents
#9
Bin Sun, Lin Li, Qing-Wen Hu, Hong-Bo Zheng, Hui Tang, Huan-Min Niu, Hui-Qing Yuan, Hong-Xiang Lou
A series of macrocyclic bisbibenzyls with novel skeletons was designed, synthesized, and evaluated for antiproliferative activity against five anthropic cancer cell lines. Among these novel molecules, compound 47 displayed excellent anticancer activity against HeLa, k562, HCC1428, HT29 and PC-3/Doc cell lines, with IC50 values ranging from of 1.51 μM-5.51 μM, which were more potent than the parent compound, marchantin C. Compounds 44 and 55 with novel bisbibenzyl skeletons also exhibited significantly improved antiproliferative potency...
February 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28220402/the-specific-absorption-rate-of-tissues-in-rats-exposed-to-electromagnetic-plane-waves-in-the-frequency-range-of-0-05-5%C3%A2-ghz-and-sarwb-in-free-moving-rats
#10
Bingxin Chen, Jiamin Wang, Hongxin Qi, Jie Zhang, Shude Chen, Xianghui Wang
As electromagnetic exposure experiments can only be performed on small animals, usually rats, research on the characteristics of specific absorption rate (SAR) distribution in the rat has received increasing interest. A series of calculations, which simulated the SAR in a male rat anatomical model exposed to electromagnetic plane waves ranging from 0.05 to 5 GHz with different incidence and polarization, were conducted. The whole-body-averaged SAR (SARwb) and the tissue-averaged SAR (SARavg) in 20 major tissues were determined...
February 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28220326/simultaneous-detection-of-severe-acute-respiratory-syndrome-middle-east-respiratory-syndrome-and-related-bat-coronaviruses-by-real-time-reverse-transcription-pcr
#11
Ji Yeong Noh, Sun-Woo Yoon, Doo-Jin Kim, Moo-Seung Lee, Ji-Hyung Kim, Woonsung Na, Daesub Song, Dae Gwin Jeong, Hye Kwon Kim
Since severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) share similar characteristics with respect to clinical signs, etiology, and transmission, methods for a rapid and accurate differential diagnosis are important. Therefore, the aim of this study was to develop a duplex real-time reverse transcription (RT)-PCR method for the simultaneous detection of these viruses. Primers and probes that target the conserved spike S2 region of human SARS-CoV, MERS-CoV, and their related bat CoVs were designed...
February 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28220053/simulation-study-on-effects-of-order-and-step-size-of-runge-kutta-methods-that-solve-contagious-disease-and-tumor-models
#12
Wang Z, Wang Q, Klinke Dj
Biological processes such as contagious disease spread patterns and tumor growth dynamics are modelled using a set of coupled differential equations. Experimental data is usually used to calibrate models so they can be used to make future predictions. In this study, numerical methods were implemented to approximate solutions to mathematical models that were not solvable analytically, such as a SARS model. More complex models such as a tumor growth model involve high-dimensional parameter spaces; efficient numerical simulation techniques were used to search for optimal or close-to-optimal parameter values in the equations...
September 2016: Journal of Computer Science and Systems Biology
https://www.readbyqxmd.com/read/28219677/nsqip-based-quality-improvement-curriculum-for-surgical-residents
#13
Mary M Mrdutt, Claire L Isbell, Justin L Regner, Bonnie R Hodges, Yolanda Munoz Maldonado, J Scott Thomas, Harry T Papaconstantinou
BACKGROUND: General surgery training has historically lacked a standardized approach to resident Quality Improvement (QI) education aside from traditional Morbidity and Mortality conference. In 2013, the Accreditation Council for Graduate Medical Education (ACGME) formalized QI as a component of residency training. Our residency chose the National Surgical Quality Improvement Program (NSQIP) Quality In-Training Initiative (QITI) as the foundation for our QI training. We hypothesized that a focused curriculum based on outcomes would produce change in culture and improve quality of patient care...
February 17, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28219011/inhibition-of-the-aldehyde-dehydrogenase-1-2-family-by-psoralen-and-coumarin-derivatives
#14
Cameron D Buchman, Thomas D Hurley
Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD+-dependent oxidation of aldehydes to their respective carboxylic acids. In this study, we further characterized the inhibition of four psoralen and coumarin derivatives towards ALDH2 and compared them to the ALDH2 inhibitor daidzin for selectivity against five ALDH1/2 isoenzymes. Compound 2 (Ki=19 nM) binds within the aldehyde-binding site of the free enzyme species of ALDH2. Thirty-three structural analogs were examined to develop a stronger SAR profile...
February 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28218676/synthesis-and-biological-evaluation-of-novel-8-morpholinoimidazo-1-2-a-pyrazine-derivatives-bearing-phenylpyridine-phenylpyrimidine-carboxamides
#15
Shan Xu, Chengyu Sun, Chen Chen, Pengwu Zheng, Yong Zhou, Hongying Zhou, Wufu Zhu
Herein we designed and synthesized three series of novel 8-morpholinoimidazo[1,2-a]pyrazine derivatives bearing phenylpyridine/phenylpyrimidine-carboxamides (compounds 12a-g, 13a-g and 14a-g). All the compounds were evaluated for their IC50 values against three cancer cell lines (A549, PC-3 and MCF-7). Most of the target compounds exhibited moderate cytotoxicity against the three cancer cell lines. Two selected compounds 14b, 14c were further tested for their activity against PI3Kα kinase, and the results indicated that compound 14c showed inhibitory activity against PI3Kα kinase with an IC50 value of 1...
February 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28216405/design-synthesis-and-biological-evaluation-of-nonsecosteroidal-vitamin-d3-receptor-ligands-as-anti-tumor-agents
#16
Bin Wang, Meixi Hao, Can Zhang
1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3, also known as calcitriol), the active form of vitamin D3, is being increasingly recognized for cancer therapy. Our previous work showed that phenyl-pyrrolyl pentane analogs, which mimicked anti-proliferative activities against several cancer cell lines of the natural secosteroidal ligand 1,25-(OH)2D3. Here, in order to optimize the structural features and discover more potent derivative, a series of nonsecosteroidal vitamin D3 receptor (VDR) ligands bearing acetylene bond linker was designed, synthesized and evaluated...
February 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28216367/identification-and-evaluation-of-potent-middle-east-respiratory-syndrome-coronavirus-mers-cov-3cl-pro-inhibitors
#17
Vathan Kumar, Jin Soo Shin, Jiun-Jie Shie, Keun Bon Ku, Chonsaeng Kim, Yun Young Go, Kai-Fa Huang, Meehyein Kim, Po-Huang Liang
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory illness with fever, cough and shortness of breath. Up to date, it has resulted in 1826 human infections, including 649 deaths. Analogous to picornavirus 3C protease (3C(pro)), 3C-like protease (3CL(pro)) is critical for initiation of the MERS-CoV replication cycle and is thus regarded as a validated drug target. As presented here, our peptidomimetic inhibitors of enterovirus 3C(pro) (6b, 6c and 6d) inhibited 3CL(pro) of MERS-CoV and severe acute respiratory syndrome coronavirus (SARS-CoV) with IC50 values ranging from 1...
February 16, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28216251/sars-cov-encoded-small-rnas-contribute-to-infection-associated-lung-pathology
#18
Lucía Morales, Juan Carlos Oliveros, Raúl Fernandez-Delgado, Benjamin Robert tenOever, Luis Enjuanes, Isabel Sola
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes lethal disease in humans, which is characterized by exacerbated inflammatory response and extensive lung pathology. To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced RNAs from the lungs of infected mice and discovered three 18-22 nt small viral RNAs (svRNAs). The three svRNAs were derived from the nsp3 (svRNA-nsp3.1 and -nsp3.2) and N (svRNA-N) genomic regions of SARS-CoV. Biogenesis of CoV svRNAs was RNase III, cell type, and host species independent, but it was dependent on the extent of viral replication...
February 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28216045/discovery-of-2-oxopiperazine-dengue-inhibitors-by-scaffold-morphing-of-a-phenotypic-high-throughput-screening-hit
#19
Cyrille S Kounde, Hui-Quan Yeo, Qing-Yin Wang, Kah Fei Wan, Hongping Dong, Ratna Karuna, Ina Dix, Trixie Wagner, Bin Zou, Oliver Simon, Ghislain M C Bonamy, Bryan K S Yeung, Fumiaki Yokokawa
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the identification of compound (S)-29, which exhibited potent anti-dengue activity in the cell-based assay across all four dengue serotypes with EC50<0.1μM. Cross-resistant analysis confirmed that the virus NS4B protein remained the target of the new oxopiperazine analogs obtained via scaffold morphing from the HTS hit 4...
February 4, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28214231/mechanisms-of-action-and-structure-activity-relationships-of-cytotoxic-flavokawain-derivatives
#20
Charlotte Thieury, Nicolas Lebouvier, Rémy Le Guével, Yann Barguil, Gaëtan Herbette, Cyril Antheaume, Edouard Hnawia, Yoshinori Asakawa, Mohammed Nour, Thierry Guillaudeux
22 Flavokawain derivatives (FKd) were obtained by one step syntheses in order to conduct a SAR study to understand the structural requirements for optimum and selective cytotoxicity. FKd and natural flavokawains A and B found into kava, a South Pacific traditional beverage, were evaluated against nine cancer and one healthy cell lines. The targeted cell cycle phases as well as the effects on the induction of apoptosis and cell cycle protein levels were investigated. Therapeutic improvements (more activity and selectivity) were achieved with FKd compared to natural flavokawains and notably with the 2',3,4',6'-tetramethoxychalcone (FKd 19)...
February 6, 2017: Bioorganic & Medicinal Chemistry
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