keyword
MENU ▼
Read by QxMD icon Read
search

Corona virus

keyword
https://www.readbyqxmd.com/read/28918638/a-rapid-blood-test-to-determine-the-active-status-and-duration-of-acute-viral-infection
#1
Tianyu Zheng, Caroline Finn, Christopher Parrett, Kunal Dhume, Ji Hae Hwang, David Sidhom, Tara Strutt, Yuen Yee Li Sip, Karl McKinstry, Qun Huo
The ability to rapidly detect and diagnose acute viral infections is crucial for infectious disease control and management. Serology testing for the presence of virus-elicited antibodies in blood is one of the methods used commonly for clinical diagnosis of viral infections. However, standard serology-based tests have a significant limitation: they cannot easily distinguish active from past, historical infections. As a result, it is difficult to determine whether a patient is currently infected with a virus or not, and on an optimal course of action, based off of positive serology testing responses...
September 17, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28859311/design-synthesis-and-antiviral-evaluation-of-novel-heteroarylcarbothioamide-derivatives-as-dual-inhibitors-of-hiv-1-reverse-transcriptase-associated-rnase-h-and-rddp-functions
#2
Angela Corona, Valentina Onnis, Alessandro Deplano, Giulia Bianco, Monica Demurtas, Simona Distinto, Yung-Chi Cheng, Stefano Alcaro, Francesca Esposito, Enzo Tramontano
In the continuous effort to identify new HIV-1 inhibitors endowed with innovative mechanisms, the dual inhibition of different viral functions would provide a significant advantage against drug-resistant variants. The HIV-1 reverse transcriptase (RT)-associated ribonuclease H (RNase H) is the only viral-encoded enzymatic activity that still lacks an efficient inhibitor. We synthesized a library of 3,5-diamino-N-aryl-1H-pyrazole-4-carbothioamide and 4-amino-5-benzoyl-N-phenyl-2-(substituted-amino)-1H-pyrrole-3-carbothioamide derivatives and tested them against RNase H activity...
August 31, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28794876/the-history-and-epidemiology-of-middle-east-respiratory-syndrome-corona-virus
#3
REVIEW
Aisha M Al-Osail, Marwan J Al-Wazzah
Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred worldwide; however, most cases of mortality have occurred in the Middle East. Owing to the predominance of outbreaks in the Middle Eastern countries, the virus was renamed a Middle East respiratory syndrome corona virus (MERS-CoV) by the Corona virus Study Group...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28774161/suggestions-on-improvement-of-infectious-disease-law-and-regulations
#4
Mijeong Park
Purpose: The study's perspective is through examining an enactment for the New amendment for legislation, to make proposals for a more rational and concrete basis in the interpretation and application of the Korean legal regime in global infectious disease emergency situations. Methods: The Republic of Korea reported its first laboratory-confirmed case of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) on 20 May 2015. Since the first index case, Korean public health authorities enforced many public health measures that were not authorized in the law...
July 25, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28763472/infectious-bronchitis%C3%A2-corona%C3%A2-virus%C3%A2-establishes-productive-infection-in-avian-macrophages-interfering-with-selected-antimicrobial-functions
#5
Aruna Amarasinghe, Mohamed Sarjoon Abdul-Cader, Sadiya Nazir, Upasama De Silva Senapathi, Frank van der Meer, Susan Catherine Cork, Susantha Gomis, Mohamed Faizal Abdul-Careem
Infectious bronchitis virus (IBV) causes respiratory disease leading to loss of egg and meat production in chickens. Although it is known that macrophage numbers are elevated in the respiratory tract of IBV infected chickens, the role played by macrophages in IBV infection, particularly as a target cell for viral replication, is unknown. In this study, first, we investigated the ability of IBV to establish productive replication in macrophages in lungs and trachea in vivo and in macrophage cell cultures in vitro using two pathogenic IBV strains...
2017: PloS One
https://www.readbyqxmd.com/read/28712204/middle-east-respiratory-syndrome-corona-virus-alert-verification-in-mirpur-azad-kashmir
#6
Mumtaz Ali Khan, Muhammad Ishaq, Mujeeb Ur Rehman, Asim Altaf, Mirza Aamir Baig, Safdar Rana, Jaleel Kamran, Muazam Abbas Ranjha, Jawad Asgher Rana
BACKGROUND: Middle East Respiratory-Corona virus (MERS-CoV), SARS like virus, identified in September 2012 in Middle-East. February 2013, an elderly man, who visited Pakistan and KSA, was confirmed as MRS-CoV in UK. A team visited Mirpur to assess current and past SARI trends in major indoor facilities, to explore possible contact of the patient with known or suspected SARI case during his stay in Pakistan and enlist close contacts. METHODS: Review of indoor records in hospitals, interviews with relatives & physicians and active contact tracing using operational case definition...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28703921/estimating-and-modelling-the-transmissibility-of-middle-east-respiratory-syndrome-coronavirus-during-the-2015-outbreak-in-the-republic-of-korea
#7
Xu-Sheng Zhang, Richard Pebody, Andre Charlett, Daniela de Angelis, Paul Birrell, Hunseok Kang, Marc Baguelin, Yoon Hong Choi
BACKGROUND: Emerging respiratory infections represent a significant public health threat. Because of their novelty, there are limited measures available to control their early spread. Learning from past outbreaks is important for future preparation. The Middle Eastern Respiratory Syndrome CoronaVirus (MERS-CoV ) 2015 outbreak in the Republic of Korea (ROK) provides one such opportunity. OBJECTIVES: We demonstrated through quantitative methodologies how to estimate MERS-CoV's transmissibility and identified the effective countermeasures that stopped its spread...
September 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28628450/zika-virus-screening-among-spanish-team-members-after-2016-rio-de-janeiro-brazil-olympic-games
#8
Natalia Rodriguez-Valero, Alberto M Borobia, Mar Lago, Maria Paz Sánchez-Seco, Fernando de Ory, Ana Vázquez, Jose Luis Pérez-Arellano, Cristina Carranza Rodríguez, Miguel J Martínez, Alicia Capón, Elias Cañas, Joaquin Salas-Coronas, Arkaitz Azcune Galparsoro, Jose Muñoz
We evaluated the risk for the Spanish Olympic Team acquiring Zika virus in Rio de Janeiro, Brazil, during 2016. We recruited 117 team members, and all tested negative for Zika virus. Lack of cases in this cohort supports the minimum risk estimates made before the Games.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28583856/a-field-based-detection-method-for-rose-rosette-virus-using-isothermal-probe-based-reverse-transcription-recombinase-polymerase-amplification-assay
#9
Binoy Babu, Brian K Washburn, Tülin Sarigül Ertek, Steven H Miller, Charles B Riddle, Gary W Knox, Francisco M Ochoa-Corona, Jennifer Olson, Yakup Zekai Katırcıoğlu, Mathews L Paret
Rose rosette disease, caused by Rose rosette virus (RRV; genus Emaravirus) is a major threat to the rose industry in the U.S. The only strategy currently available for disease management is early detection and eradication of the infected plants, thereby limiting its potential spread. Current RT-PCR based diagnostic methods for RRV are time consuming and are inconsistent in detecting the virus from symptomatic plants. Real-time RT-qPCR assay is highly sensitive for detection of RRV, but it is expensive and requires well-equipped laboratories...
June 2, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28560632/improvements-in-brain-and-behavior-following-eradication-of-hepatitis-c
#10
Taylor Kuhn, Philip Sayegh, Jacob D Jones, Jason Smith, Manoj K Sarma, A Ragin, Elyse J Singer, M Albert Thomas, April D Thames, Steven A Castellon, Charles H Hinkin
Despite recent advances in treatment, hepatitis C remains a significant public health problem. The hepatitis C virus (HCV) is known to infiltrate the brain, yet findings from studies on associated neurocognitive and neuropathological changes are mixed. Furthermore, it remains unclear if HCV eradication improves HCV-associated neurological compromise. This study examined the longitudinal relationship between neurocognitive and neurophysiologic markers among healthy HCV- controls and HCV+ adults following successful HCV eradication...
May 30, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28542235/environmental-persistence-of-porcine-coronaviruses-in-feed-and-feed-ingredients
#11
Michaela P Trudeau, Harsha Verma, Fernando Sampedro, Pedro E Urriola, Gerald C Shurson, Sagar M Goyal
Porcine Epidemic Diarrhea Virus (PEDV), Porcine Delta Corona Virus (PDCoV), and Transmissible Gastroenteritis Virus (TGEV) are major threats to swine health and contaminated feed plays a role in virus transmission. The objective of our study was to characterize inactivation of PEDV, PDCoV, and TGEV in various feed ingredient matrices. Samples of complete feed, spray dried porcine plasma, meat meal, meat and bone meal, blood meal, corn, soybean meal, and corn dried distillers grains with solubles were weighed (5 g/sample) into scintillation vials and inoculated with 1 mL of PEDV, PDCoV, or TGEV...
2017: PloS One
https://www.readbyqxmd.com/read/28500421/seasonal-fluctuations-of-astrovirus-but-not-coronavirus-shedding-in-bats-inhabiting-human-modified-tropical-forests
#12
Anne Seltmann, Victor M Corman, Andrea Rasche, Christian Drosten, Gábor Á Czirják, Henry Bernard, Matthew J Struebig, Christian C Voigt
Emerging infectious diseases (EIDs) are considered a major threat to global health. Most EIDs appear to result from increased contact between wildlife and humans, especially when humans encroach into formerly pristine habitats. Habitat deterioration may also negatively affect the physiology and health of wildlife species, which may eventually lead to a higher susceptibility to infectious agents and/or increased shedding of the pathogens causing EIDs. Bats are known to host viruses closely related to important EIDs...
May 12, 2017: EcoHealth
https://www.readbyqxmd.com/read/28498951/single-target-and-multiplex-discrimination-of-whiteflies-hemiptera-aleyrodidae-bemisia-tabaci-and-trialeurodes-vaporariorum-with-modified-priming-oligonucleotide-thermodynamics
#13
Sharon A Andreason, Mohammad Arif, Judith K Brown, Francisco Ochoa-Corona, Jacqueline Fletcher, Astri Wayadande
The whitefly species Bemisia tabaci (Gennadius) and Trialeurodes vaporariorum (Westwood) are worldwide agricultural pests and virus vectors. Bemisia tabaci, in particular, is often transported internationally via trade routes leading to potential introductions of exotic whiteflies or plant viruses. Quick identification of agriculturally important whiteflies can facilitate interventions that prevent these cross-border introductions. Polymerase chain reaction (PCR) primers were designed to amplify the mitochondrial cytochrome oxidase I gene (mtCOI) sequence of members of the B...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28373864/chelation-motifs-affecting-metal-dependent-viral-enzymes-n-acylhydrazone-ligands-as-dual-target-inhibitors-of-hiv-1-integrase-and-reverse-transcriptase-ribonuclease-h-domain
#14
Mauro Carcelli, Dominga Rogolino, Anna Gatti, Nicolino Pala, Angela Corona, Alessia Caredda, Enzo Tramontano, Christophe Pannecouque, Lieve Naesens, Francesca Esposito
Human immunodeficiency virus type 1 (HIV-1) infection, still represent a serious global health emergency. The chronic toxicity derived from the current anti-retroviral therapy limits the prolonged use of several antiretroviral agents, continuously requiring the discovery of new antiviral agents with innovative strategies of action. In particular, the development of single molecules targeting two proteins (dual inhibitors) is one of the current main goals in drug discovery. In this contest, metal-chelating molecules have been extensively explored as potential inhibitors of viral metal-dependent enzymes, resulting in some important classes of antiviral agents...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28329739/peptides-derived-from-glycoproteins-h-and-b-of-herpes-simplex-virus-type-1-and-herpes-simplex-virus-type-2-are-capable-of-blocking-herpetic-infection-in-vitro
#15
Abraham Cetina-Corona, Uriel López-Sánchez, Juana Salinas-Trujano, Alfonso Méndez-Tenorio, Blanca Lilia Barrón, Jesus Torres-Flores
AIMS: The aim of this study was to design peptides derived from glycoproteins H (gH) and B (gB) of herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) with the potential to block herpetic infection and to evaluate their ability to inhibit HSV-1 and HSV-2 infection in vitro. METHODS: A library of continuous 15-25 residue stretches (CRSs) located at the surface of gH and gB from HSV-1 and HSV-2 was created. These CRSs were analyzed, and only those that were highly flexible and rich in charged residues were selected for the design of the antiviral peptides (AVPs)...
2016: Intervirology
https://www.readbyqxmd.com/read/28270191/isolation-and-molecular-characterisation-of-halicephalobus-gingivalis-in-the-brain-of-a-horse-in-piedmont-italy
#16
Maria Domenica Pintore, Francesco Cerutti, Antonio D'Angelo, Cristiano Corona, Paola Gazzuola, Loretta Masoero, Corrado Colombo, Roberto Bona, Carlo Cantile, Simone Peletto, Cristina Casalone, Barbara Iulini
BACKGROUND: A fatal case of meningoencephalitis was reported in a 13-year-old Koninklijk Warmbloed Paard Nederland stallion, suspected of West Nile virus (WNV) infection, in the Piedmont region of Italy. Clinical signs included right head tilt and circling, depression alternated with excitability, fever and lateral strabismus. Combined treatment consisting of dimethylsulfoxide, dexamethasone, sulphonamides and sedative was administered, but because of the poor conditions the horse was euthanatized and submitted for necropsy...
March 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28177112/psychobehavioural-responses-to-the-2014-middle-east-respiratory-syndrome-novel-corona-virus-mers-cov-among-adults-in-two-shopping-malls-in-jeddah-western-saudi-arabia
#17
N S AlNajjar, L M Attar, F M Farahat, A AlThaqafi
Sporadic cases of Middle East respiratory syndrome caused by a novel corona virus (MERS-CoV) were first detected in Saudi Arabia in June 2012. The number of cases was highest during April and May 2014. To assess determinants of psychobehavioural responses among the general population in Jeddah, western Saudi Arabia, a cross-sectional survey was conducted at the end of June 2014. Data included sociodemographic characteristics, level of anxiety, protective measures and social avoidance responses. A total of 358 participants completed the questionnaire; 58...
February 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28144057/respiratory-viruses-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#18
Parvaiz A Koul, Hyder Mir, Shabir Akram, Varsha Potdar, Mandeep S Chadha
OBJECTIVE: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) cause significant morbidity, mortality, and an inexorable decline of lung function. Data from developed countries have shown viruses to be important causes of AECOPD, but data from developing countries like India are scant. We set out to determine the contribution of viruses in the causation of hospitalized patients with AECOPD. METHODS: Twin nasopharyngeal/oropharyngeal swabs collected from 233 patients admitted with an acute AECOPD and tested for respiratory viruses including respiratory syncytial virus A and B, parainfluenza were (PIV) 1, 2, 3, and 4, human metapneumovirus (hMPV) A and B, influenza A and B, enterovirus, corona NL65, OC43, and 229E viruses, adenovirus 2 and 4, rhinovirus, and bocavirus, by duplex real time reverse-transcription polymerase chain reaction (qRT-PCR) using CDC approved primers and probes...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28133694/spontaneous-intracranial-hemorrhage-in-a-patient-with-middle-east-respiratory-syndrome-corona-virus
#19
Fahad M Al-Hameed
The Middle East respiratory syndrome corona virus (MERS-CoV) is a novel positive sense singlestranded ribonucleic acid virus of the genus Beta corona virus. This virus was first isolated from a patient who died from severe respiratory illness in June 2012 in Jeddah, Kingdom of Saudi Arabia. We describe an unusual case of a 42 year old healthcare worker who was admitted to our Intensive Care Unit (ICU)King Abdul-Aziz Medical City, with MERS-CoV and severe acute respiratory distress Syndrome and developed a sudden-onset diabetes insipidus and spontaneous massive intracranial hemorrhage with intra-ventricular extension and tonsillar herniation...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28118607/middle-east-respiratory-syndrome-corona-virus-spike-glycoprotein-suppresses-macrophage-responses-via-dpp4-mediated-induction-of-irak-m-and-ppar%C3%AE
#20
Ahmed A Al-Qahtani, Konstantina Lyroni, Marina Aznaourova, Melpomeni Tseliou, Mashael R Al-Anazi, Mohammed N Al-Ahdal, Saad Alkahtani, George Sourvinos, Christos Tsatsanis
Middle East Respiratory Syndrome Corona Virus (MERS-CoV) is transmitted via the respiratory tract and causes severe Acute Respiratory Distress Syndrome by infecting lung epithelial cells and macrophages. Macrophages can readily recognize the virus and eliminate it. MERS-CoV infects cells via its Spike (S) glycoprotein that binds on Dipeptidyl-Peptidase 4 (DPP4) receptor present on macrophages. Whether this Spike/DPP4 association affects macrophage responses remains unknown. Herein we demonstrated that infection of macrophages with lentiviral particles pseudotyped with MERS-CoV S glycoprotein results in suppression of macrophage responses since it reduced the capacity of macrophages to produce TNFα and IL-6 in naive and LPS-activated THP-1 macrophages and augmented LPS-induced production of the immunosuppressive cytokine IL-10...
February 7, 2017: Oncotarget
keyword
keyword
14431
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"