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https://www.readbyqxmd.com/read/27923923/antiviral-innate-immune-response-interferes-with-the-formation-of-replication-associated-membrane-structures-induced-by-a-positive-strand-rna-virus
#1
Diede Oudshoorn, Barbara van der Hoeven, Ronald W A L Limpens, Corrine Beugeling, Eric J Snijder, Montserrat Bárcena, Marjolein Kikkert
: Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived double-membrane vesicles (DMVs) and other membrane structures. This network is thought to accommodate the viral replication machinery and protect it from innate immune detection. We hypothesized that the innate immune response has tools to counteract the formation of these virus-induced replication organelles in order to inhibit virus replication...
December 6, 2016: MBio
https://www.readbyqxmd.com/read/27915036/a-rapid-assay-for-detection-of-rose-rosette-virus-using-reverse-transcription-recombinase-polymerase-amplification-using-multiple-gene-targets
#2
Binoy Babu, Brian K Washburn, Steven H Miller, Kristina Poduch, Tulin Sarigul, Gary W Knox, Francisco M Ochoa-Corona, Mathews L Paret
Rose rosette disease caused by Rose rosette virus (RRV; genus Emaravirus) is the most economically relevant disease of Knock Out(®) series roses in the U.S. As there are no effective chemical control options for the disease, the most critical disease management strategies include the use of virus free clean plants for propagation and early detection and destruction of infected plants. The current diagnostic techniques for RRV including end-point reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR (RT-qPCR) are highly sensitive, but limited to diagnostic labs with the equipment and expertise; and is time consuming...
November 30, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27864902/quantitative-structure-activity-relationship-and-molecular-docking-revealed-a-potency-of-anti-hepatitis-c-virus-drugs-against-human-corona-viruses
#3
Abdo A Elfiky, Samah M Mahdy, Wael M Elshemey
A number of human coronaviruses (HCoVs) were reported in the last and present centuries. Some outbreaks of which (e.g. SARS and MERS CoVs) caused the mortality of hundreds of people worldwide. The problem of finding a potent drug against HCoV strains lies in the inability of finding a drug that stops the viral replication through inhibiting its important proteins. In spite of its limited efficacy and potential side effects, Ribavirin is extensively used as a first choice against HCoVs. Therefore, scientists reverted towards the investigation of different drugs that can more specifically target proteins...
November 19, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27766892/isatin-thiazoline-hybrids-as-dual-inhibitors-of-hiv-1-reverse-transcriptase
#4
Rita Meleddu, Simona Distinto, Angela Corona, Enzo Tramontano, Giulia Bianco, Claudia Melis, Filippo Cottiglia, Elias Maccioni
A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to study their activity on both HIV-1 (Human Immunodeficiency Virus type 1) RT (Reverse Transcriptase) associated functions. These derivatives are analogs of previously reported series whose biological activity and mode of action have been investigated. In this work we investigated the influence of the introduction of a methyl group in the position 3 of the dihydrothiazole ring and of a chlorine atom in the position 5 of the isatin nucleus...
October 21, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27753796/etiology-of-acute-respiratory-infections-in-infants-a-prospective-birth-cohort-study
#5
Prawin Kumar, Guruprasad R Medigeshi, Vishnu S Mishra, Mojahidul Islam, Shivani Randev, Aparna Mukherjee, Rama Chaudhry, Arti Kapil, Kana Ram Jat, Rakesh Lodha, Sushil K Kabra
BACKGROUND: There is paucity of studies on etiology of acute respiratory infections (ARI) in infants. OBJECTIVE: To document incidence and etiology of ARI in infants, their seasonal variability and association of clinical profile with etiology. MATERIAL AND METHODS: A birth cohort was followed for the first year of life; for each episode of ARI, nasopharyngeal aspirates were collected to identify the causative respiratory virus/es using multiplex real time PCR assay...
October 6, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27729119/the-ubiquity-of-asymptomatic-respiratory-viral-infections-in-the-tonsils-and-adenoids-of-children-and-their-impact-on-airway-obstruction
#6
Howard Faden, Vincent Callanan, Michael Pizzuto, Mark Nagy, Mark Wilby, Daryl Lamson, Brian Wrotniak, Stefan Juretschko, Kirsten St George
BACKGROUND: Airway obstruction due to enlargement of tonsils and adenoids is a common pediatric problem resulting in sleep disordered breathing. The cause for the relatively abnormal growth of tonsils and adenoids is poorly understood. METHODS: Non-acutely ill children undergoing tonsillectomy and adenoidectomy (T&A) for various reasons were enrolled prospectively in a study to determine the frequency of asymptomatic respiratory viral infections in each lymphoid tissue and to relate the number and types of virus to the degree of airway obstruction...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27712621/supramolecular-architecture-of-the-coronavirus-particle
#7
B W Neuman, M J Buchmeier
Coronavirus particles serve three fundamentally important functions in infection. The virion provides the means to deliver the viral genome across the plasma membrane of a host cell. The virion is also a means of escape for newly synthesized genomes. Lastly, the virion is a durable vessel that protects the genome on its journey between cells. This review summarizes the available X-ray crystallography, NMR, and cryoelectron microscopy structural data for coronavirus structural proteins, and looks at the role of each of the major structural proteins in virus entry and assembly...
2016: Advances in Virus Research
https://www.readbyqxmd.com/read/27703605/awareness-of-droplet-and-airborne-isolation-precautions-among-dental-health-professionals-during-the-outbreak-of-corona-virus-infection-in-riyadh-city-saudi-arabia
#8
Mohammad-Abdul Baseer, Shahzeb-Hasan Ansari, Sultan-Saleh AlShamrani, Abdul-Rahman Alakras, Raif Mahrous, Abdul-Majeed Alenazi
BACKGROUND: This study aimed to determine knowledge, attitude and practice of airborne and droplet isolation precautions among Dental Health Professionals (DHPs) (dental students, interns, practitioners and auxiliaries) during the outbreak of MERS (Middle East Respiratory Syndrome), corona virus infection in Riyadh city, Saudi Arabia. MATERIAL AND METHODS: A cross-sectional survey was conducted among 406 dental health professionals (DHPs) working in selected dental facilities in Riyadh city, Saudi Arabia during the outbreak of MERS (April-June 2013)...
October 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27660213/viral-diversity-prey-preference-and-bartonella-prevalence-in-desmodus-rotundus-in-guatemala
#9
Amy K Wray, Kevin J Olival, David Morán, Maria Renee Lopez, Danilo Alvarez, Isamara Navarrete-Macias, Eliza Liang, Nancy B Simmons, W Ian Lipkin, Peter Daszak, Simon J Anthony
Certain bat species serve as natural reservoirs for pathogens in several key viral families including henipa-, lyssa-, corona-, and filoviruses, which may pose serious threats to human health. The Common Vampire Bat (Desmodus rotundus), due to its abundance, sanguivorous feeding habit involving humans and domestic animals, and highly social behavioral ecology, may have an unusually high potential for interspecies disease transmission. Previous studies have investigated rabies dynamics in D. rotundus, yet the diversity of other viruses, bacteria, and other microbes that these bats may carry remains largely unknown...
September 22, 2016: EcoHealth
https://www.readbyqxmd.com/read/27623039/chronic-hepatitis-c-treatment-with-direct-acting-antiviral-agents-in-a-real-life-setting
#10
Ruby Ann Chirino-Sprung, Margarita Dehesa, Enrique Wolpert, Clara Corona-Lau, Ignacio García-Juarez, José Francisco Sánchez-Ávila, Carlos Moctezuma-Velázquez, David Kershenobich
BACKGROUND: In clinical trials, new oral direct-acting antiviral agent therapies have demonstrated a high sustained virological response rate in patients with hepatitis C virus infection. We aimed to analyze the efficacy and safety data from direct-acting antiviral agent interferon-free therapy in hepatitis C virus infection in a study performed in five different clinical settings in Mexico City; four private practice sites and one academic medical center in a real-world scenario. METHODS: Eighty-one patients were treated with seven different direct-acting antiviral agent regimens, in which the end of treatment, sustained virological response at 12 weeks post-treatment, and adverse effects were evaluated...
July 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27609728/in-the-era-of-corona-virus-health-care-professionals-knowledge-attitudes-and-practice-of-hand-hygiene-in-saudi-primary-care-centers-a-cross-sectional-study
#11
Ali Alfahan, Samia Alhabib, Imad Abdulmajeed, Saeed Rahman, Samira Bamuhair
BACKGROUND: Hand hygiene is one of the essential means to prevent the spread of infections. The aim of this study was to assess the knowledge, attitudes, and practice (KAP) of hand hygiene in primary care settings. METHODS: A cross-sectional study using a self-reported questionnaire was conducted in primary care settings located in Riyadh, Kingdom of Saudi Arabia, under the service of King Abdulaziz Medical City (KAMC). The Institutional Review Board of KAMC Research Centre approved the study...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27552321/synthetic-virus-like-particles-prepared-via-protein-corona-formation-enable-effective-vaccination-in-an-avian-model-of-coronavirus-infection
#12
Hui-Wen Chen, Chen-Yu Huang, Shu-Yi Lin, Zih-Syun Fang, Chen-Hsuan Hsu, Jung-Chen Lin, Yuan-I Chen, Bing-Yu Yao, Che-Ming J Hu
The ongoing battle against current and rising viral infectious threats has prompted increasing effort in the development of vaccine technology. A major thrust in vaccine research focuses on developing formulations with virus-like features towards enhancing antigen presentation and immune processing. Herein, a facile approach to formulate synthetic virus-like particles (sVLPs) is demonstrated by exploiting the phenomenon of protein corona formation induced by the high-energy surfaces of synthetic nanoparticles...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27550352/identification-of-nafamostat-as-a-potent-inhibitor-of-middle-east-respiratory-syndrome-mers-corona-virus-s-mediated-membrane-fusion-using-the-split-protein-based-cell-cell-fusion-assay
#13
Mizuki Yamamoto, Shutoku Matsuyama, Xiao Li, Makoto Takeda, Yasushi Kawaguchi, Jun-Ichiro Inoue, Zene Matsuda
Middle East respiratory syndrome (MERS) is an emerging infectious disease associated with a relatively high mortality rate of approximately 40%. MERS is caused by MERS corona virus (MERS-CoV) infection, and no specific drugs or vaccines are currently available to prevent MERS-CoV infection. MERS-CoV is an enveloped virus and its envelope protein (S protein) mediates membrane fusion at the plasma membrane or endosomal membrane. Multiple proteolysis by host proteases, such as furin, transmembrane protease serine 2 (TMPRSS2), and cathepsins, causes the S protein to become fusion competent...
August 22, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27437361/knowledge-and-apprehension-of-dental-patients-about-mers-a-questionnaire-survey
#14
Nipun Ashok, Jean Clare Rodrigues, Khalid Azouni, Shorouk Darwish, Abdulwahab Abuderman, Abdul Aziz Fahad Alkaabba, Bassel Tarakji
INTRODUCTION: Middle East Respiratory Syndrome (MERS) is a disease caused by beta corona virus. From April 11(th) to 9(th) June 2014, World Health Organization (WHO) reported a total of 402 laboratory confirmed cases of MERS from KSA, out of which 132 cases were reported from Riyadh alone. AIM: The aim of this study was to assess the knowledge and apprehension of patients about MERS visiting Al Farabi College of Dentistry, Riyadh, Saudi Arabia. MATERIALS AND METHODS: A cross-sectional questionnaire based survey was conducted which consisted of 10 self-prepared questions...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27433376/collaborative-intervention-of-middle-east-respiratory-syndrome-rapid-response-team
#15
REVIEW
Jacob Lee, Woo Joo Kim
On May 20th 2015, a 68 year old man was the first to be diagnosed with Middle East Respiratory Syndrome-Corona Virus (MERS-CoV) in Korea. He travelled to Bahrain, Saudi Arabia, and Qatar for 16 days. On May 4th 2015, the patient entered Korea, with febrile sense and respiratory symptoms that appeared on May 11th. The MERS-CoV Outbreak became worse and several patients had to be admitted throughout various hospitals starting at the beginning of June. This situation led to a nationwide chaos. The Rapid Response Team (RRT) was organized after the Korean government's calling for specialists that were composed of 15 Infectious disease Doctors and 2 Infection Control professionals on the 8th of June 2015...
June 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27332622/a-highly-sensitive-molecular-detection-platform-for-robust-and-facile-diagnosis-of-middle-east-respiratory-syndrome-mers-corona-virus
#16
Il Young Jung, Jae Bem You, Bo Ram Choi, Ji Su Kim, Hyun Kyung Lee, Bora Jang, Han Saem Jeong, Kyuri Lee, Sung Gap Im, Hyukjin Lee
Trail polymerization enables a significant enhancement of the DhITACT system. DhITACT-Trail (DNA hydrogel formation by isothermal amplification of complementary targets trail polymerization) offers a robust diagnosis of target RNA strands in pseudo-serum specimen. This system requires minimum liquid handling as compared to conventional analysis. In addition, a definitive diagnostic result can be achieved within 30 min by an optical detection.
September 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27298584/challenges-presented-by-mers-corona-virus-and-sars-corona-virus-to-global-health
#17
REVIEW
Ali Al-Hazmi
Numerous viral infections have arisen and affected global healthcare facilities. Millions of people are at severe risk of acquiring several evolving viral infections through several factors. In the present article we have described about risk factors, chance of infection, and prevention methods of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and severe acute respiratory syndrome (SARS-CoV), human coronaviruses (CoVs) frequently cause a normal cold which is mild and self-restricting. Zoonotic transmission of CoVs such as the newly discovered MERS-CoV and SARS-CoV, may be associated with severe lower respiratory tract infection...
July 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27210549/development-of-a-rapid-sensitive-taqman-real-time-rt-pcr-assay-for-the-detection-of-rose-rosette-virus-using-multiple-gene-targets
#18
Binoy Babu, Ayyamperumal Jeyaprakash, Debra Jones, Timothy S Schubert, Carlye Baker, Brian K Washburn, Steven H Miller, Kristina Poduch, Gary W Knox, Francisco M Ochoa-Corona, Mathews L Paret
Rose rosette virus (RRV), belonging to the genus Emaravirus, is a highly destructive pathogen that causes rose rosette disease. The disease is a major concern for the rose industry in the U.S. due to the lack of highly sensitive methods for early detection of RRV. This is critical, as early identification of the infected plants and eradication is necessary in minimizing the risks associated with the spread of the disease. A highly reliable, specific and sensitive detection assay is thus required to test and confirm the presence of RRV in suspected plant samples...
September 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27161176/a-combined-in-silico-in%C3%A2-vitro-approach-unveils-common-molecular-requirements-for-efficient-bvdv-rdrp-binding-of-linear-aromatic-n-polycyclic-systems
#19
A Carta, I Briguglio, S Piras, P Corona, R Ibba, E Laurini, M Fermeglia, S Pricl, N Desideri, E M Atzori, P La Colla, G Collu, I Delogu, R Loddo
In this work, we present and discuss a comprehensive set of both newly and previously synthesized compounds belonging to 5 distinct molecular classes of linear aromatic N-polycyclic systems that efficiently inhibits bovine viral diarrhea virus (BVDV) infection. A coupled in silico/in vitro investigation was employed to formulate a molecular rationale explaining the notable affinity of all molecules to BVDV RNA dependent RNA polymerase (RdRp) NS5B. We initially developed a three-dimensional common-feature pharmacophore model according to which two hydrogen bond acceptors and one hydrophobic aromatic feature are shared by all molecular series in binding the viral polymerase...
July 19, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27158557/clinical-and-epidemiological-characterization-of-laboratory-confirmed-autochthonous-cases-of-zika-virus-disease-in-mexico
#20
Maria Eugenia Jimenez Corona, Ana Lucía De la Garza Barroso, Jose Cruz Rodriguez Martínez, Norma Irene Luna Guzmán, Cuitláhuac Ruiz Matus, José Alberto Díaz Quiñonez, Irma Lopez Martinez, Pablo A Kuri Morales
INTRODUCTION: Since 2014, autochthonous circulation of Zika virus (ZIKV) in the Americas was detected (Easter Island, Chile). In May 2015, Brazil confirmed autochthonous --transmission and in October of that year Colombia reported their first  cases. Now more than 52 countries have reported cases, including Mexico. To deal with this contingency in Mexico, several surveillance systems, in addition to systems for vector-borne diseases were strengthened with the participation of all health institutions...
2016: PLoS Currents
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