keyword
MENU ▼
Read by QxMD icon Read
search

CRM

keyword
https://www.readbyqxmd.com/read/28213229/fast-method-to-quantify-pahs-in-contaminated-soils-by-direct-thermodesorption-using-analytical-pyrolysis
#1
C Biache, C Lorgeoux, A Saada, S Colombano, P Faure
A method for polycyclic aromatic hydrocarbon (PAH) quantification, based on pyrolysis at 450°C combined with gas chromatography coupled with mass spectrometry and flame ionization detection (Py-GC-MS/FID), was developed and compared to a conventional PAH quantification method using accelerated solvent extraction and GC-MS analyses. The PAH contents of three coking plant soils, one gas plant soil, two wood-treating facility soils and one certified reference material (CRM - BCR 524) were determined using both methods...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28210760/-risk-management-in-anesthesia-and-critical-care-medicine
#2
C Eisold, A R Heller
Throughout its history, anesthesia and critical care medicine has experienced vast improvements to increase patient safety. Consequently, anesthesia has never been performed on such a high level as it is being performed today. As a result, we do not always fully perceive the risks involved in our daily activity. A survey performed in Swiss hospitals identified a total of 169 hot spots which endanger patient safety. It turned out that there is a complex variety of possible errors that can only be tackled through consistent implementation of a safety culture...
February 16, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28196217/pathologic-outcomes-of-laparoscopic-vs-open-mesorectal-excision-for-rectal-cancer-a-systematic-review-and-meta-analysis
#3
Aleix Martínez-Pérez, Maria Clotilde Carra, Francesco Brunetti, Nicola de'Angelis
Importance: Rectal resection with mesorectal excision is the mainstay treatment for rectal cancer. Objective: To review and analyze the evidence concerning the pathologic outcomes of laparoscopic (LRR) vs open (ORR) rectal resection for rectal cancer. Data Sources: The Cochrane Central Register of Controlled Trials, MEDLINE (through PubMed), EMBASE, Scopus databases, and clinicaltrials.gov were searched for randomized clinical trials (RCTs) comparing LRR vs ORR...
February 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28183282/enhanced-and-long-term-immunogenicity-of-a-her-2-neu-multi-epitope-vaccine-conjugated-to-the-carrier-crm197-in-conjunction-with-the-adjuvant-montanide
#4
Joshua Tobias, Joanna Jasinska, Karin Baier, Michael Kundi, Nicholas Ede, Christoph Zielinski, Ursula Wiedermann
BACKGROUND: We previously identified three short single peptides (P4, P6 and P7) representing different B-cell epitopes on the extracellular domain of Her-2/neu for a vaccine that was tested in a phase-I clinical trial. Here we describe the improvement of the multi peptide vaccine by fusing the single peptides to a hybrid peptide P467. METHODS: After coupling to either virosomes or to diphtheria toxoid CRM197 (CRM), the hybrid peptide was tested in different concentrations in combination with either Montanide or Aluminium hydroxide (Alum) in preclinical studies...
February 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28153266/optimization-of-high-resolution-continuum-source-graphite-furnace-atomic-absorption-spectrometry-for-direct-analysis-of-selected-trace-elements-in-whole-blood-samples
#5
Magdalena Wójciak-Kosior, Wojciech Szwerc, Maciej Strzemski, Zoltan Wichłacz, Jan Sawicki, Ryszard Kocjan, Michał Latalski, Ireneusz Sowa
Trace analysis plays an important role in medicine for diagnosis of various disorders; however, the appropriate sample preparation is required mostly including mineralization. Although graphite furnace atomic absorption spectrometry (GF AAS) allows the investigation of biological samples such as blood, serum, and plasma without this step, it is rarely used for direct analysis because the residues of the rich organic matrix inside the furnace are difficult to remove and this may cause spectral/matrix interferences and decrease the lifetime of the graphite tube...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28153251/selective-and-sensitive-determination-of-as-iii-and-tas-in-chinese-herbal-medicine-samples-using-l-cysteine-modified-carbon-paste-electrode-based-electrolytic-hydride-generation-and-afs-analysis
#6
Xiao-Ping Lu, Xin-An Yang, Lin Liu, Hui-Hui Hu, Wang-Bing Zhang
A novel non-chromatographic speciation technique for ultra-trace arsenite [As(III)] and total arsenic (tAs) in Chinese herbal medicine (CHM) is developed and validated by electrolytic hydride generation (EHG) coupled with atomic fluorescence spectrometry (AFS). The studies show that As(III) can be converted efficiently to AsH3 on an L-cysteine modified carbon paste electrode (CMCPE), which has never been reported before. Significantly, other arsenic species such as arsenate [As(V)], monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) do not form any or only less volatile hydrides at low applied current mode (<1...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28118954/does-circumferential-tumor-location-affect-the-circumferential-resection-margin-status-in-mid-and-low-rectal-cancer
#7
Byung Mo Kang, Yong-Koo Park, Sun Jin Park, Kil Yeon Lee, Chang Woo Kim, Suk-Hwan Lee
BACKGROUND/OBJECTIVE: The purpose of this study was to assess the impact of circumferential tumor location on circumferential resection margin (CRM) status and the depth of tumor invasion in mid and low rectal cancer. METHODS: We retrospectively analyzed whole-mount slides of 58 patients who underwent total mesorectal excision for mid and low rectal cancer. The rate of tumor-positive CRM was compared according to the circumferential tumor location. In 31 patients, morphometric analyses of whole-mount specimens were performed to measure the depth of tumor invasion according to circumferential tumor location...
January 21, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28117813/setting-up-a-stroke-team-algorithm-and-conducting-simulation-based-training-in-the-emergency-department-a-practical-guide
#8
Damla Tahtali, Ferdinand Bohmann, Peter Rostek, Marlies Wagner, Helmuth Steinmetz, Waltraud Pfeilschifter
Time is of the essence when caring for an acute stroke patient. The ultimate goal is to restore blood flow to the ischemic brain. This can be achieved by either thrombolysis with recombinant tissue-plasminogen activator (rt-PA), the standard therapy for stroke patients who present within the first hours of symptom onset without contraindications, or by an endovascular approach, if a proximal brain vessel occlusion is detected. As the efficacy of both therapies declines over time, every minute saved along the way will improve the patient's outcome...
January 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28105657/a-nomogram-to-predict-distant-metastasis-after-neoadjuvant-chemoradiotherapy-and-radical-surgery-in-patients-with-locally-advanced-rectal-cancer
#9
Yanwu Sun, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
PURPOSE: To compare distant metastasis (DM) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery alone, and to develop a predictive nomogram for DM following nCRT. METHODS: Propensity-scoring match analysis was performed to compare DM in LARC treated with nCRT (n = 375) and surgery alone (n = 375). Cox regression was performed to identify predictors of DM following nCRT. A nomogram was developed and validated by internal (n = 425) and external validation (n = 97)...
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28105170/expression-of-chromosomal-regional-maintenance-protein-1-may-be-associated-with-subcellular-survivin-expression-in-human-gastric-and-colorectal-carcinoma
#10
Michiko Shintani, Akito Tashiro, Akiko Sangawa, Naoki Yamao, Shingo Kamoshida
Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and subcellular localization of CRM-1 in human gastric and colorectal carcinomas and to assess the association between CRM-1 and survivin expression in these tumor types. The nuclear and cytoplasmic CRM-1 expression rates in gastric carcinoma were 61% (42/69) and 29% (20/69), respectively, while the nuclear and cytoplasmic CRM-1 expression rates in colorectal carcinoma were 55% (43/78) and 37% (29/78), respectively...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28099870/single-embryo-resolution-quantitative-analysis-of-reporters-permits-multiplex-spatial-cis-regulatory-analysis
#11
Catherine L Guay, Sean T McQuade, Jongmin Nam
Cis-regulatory modules (CRMs) control spatiotemporal gene expression patterns in embryos. While measurement of quantitative CRM activities has become efficient, measurement of spatial CRM activities still relies on slow, one-by-one methods. To overcome this bottleneck, we have developed a high-throughput method that can simultaneously measure quantitative and spatial CRM activities. The new method builds profiles of quantitative CRM activities measured at single-embryo resolution in many mosaic embryos and uses these profiles as a 'fingerprint' of spatial patterns...
February 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28094415/outcome-of-nonunion-fractures-in-dogs-treated-with-fixation-compression-resistant-matrix-and-recombinant-human-bone-morphogenetic-protein-2
#12
Anna M Massie, Amy S Kapatkin, Mark C Fuller, Frank J M Verstraete, Boaz Arzi
OBJECTIVES: To report the use of compression resistant matrix (CRM) infused with recombinant human bone morphogenetic protein (rhBMP-2) prospectively in the healing of nonunion long-bone fractures in dogs. METHODS: A longitudinal cohort of dogs that were presented with nonunion fractures were classified and treated with CRM soaked with rhBMP-2 and fracture fixation. They were followed with serial radiographs and evaluated for healing times and complications according to the time frame and definitions previously established for orthopaedic clinical cases...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28087370/laparoscopic-versus-open-surgery-for-rectal-cancer-a-meta-analysis-of-classic-randomized-controlled-trials-and-high-quality-nonrandomized-studies-in-the-last-5-years
#13
REVIEW
Ke Chen, Guodong Cao, Bo Chen, Mingqing Wang, Xingyu Xu, Wenwen Cai, Yicheng Xu, Maoming Xiong
OBJECTIVE: To present a meta-analysis of high-quality published reports comparing laparoscopic rectal resection (LRR) and open rectal resection (ORR) for rectal cancer. METHODS: Studies that compared LRR and ORR and were published within the last 5 years were identified. All eligible randomized controlled trials (RCTs) and non-randomized comparative trials (NRCTs) were evaluated based on the Jadad score, the Cochrane risk of bias assessment tool and modified Methodological Indices for Nonrandomized Studies (MINORS)...
January 11, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28043865/investigation-of-the-cutaneous-penetration-behavior-of-dexamethasone-loaded-to-nano-sized-lipid-particles-by-epr-spectroscopy-and-confocal-raman-and-laser-scanning-microscopy
#14
Silke B Lohan, Siavash Saeidpour, Agnieszka Solik, Sabine Schanzer, Heike Richter, Pin Dong, Maxim E Darvin, Roland Bodmeier, Alexa Patzelt, Gaith Zoubari, Michael Unbehauen, Rainer Haag, Jürgen Lademann, Christian Teutloff, Robert Bittl, Martina C Meinke
An improvement of the penetration efficiency combined with the controlled release of actives in the skin can facilitate the medical treatment of skin diseases immensely. Dexamethasone (Dx), a synthetic glucocorticoid, is frequently used for the treatment of inflammatory skin diseases. To investigate the penetration of nano-sized lipid particles (NLP) loaded with Dx in comparison to a commercially available base cream, different techniques were applied. Electron paramagnetic resonance (EPR) spectroscopy was used to monitor the penetration of Dx, which was covalently labeled with the spin probe 3-(Carboxy)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (PCA)...
December 30, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28040561/development-and-characterization-of-anti-inflammatory-activity-of-curcumin-loaded-biodegradable-microspheres-with-potential-use-in-intestinal-inflammatory-disorders
#15
E Blanco-García, F J Otero-Espinar, J Blanco-Méndez, J M Leiro-Vidal, A Luzardo-Álvarez
This research addresses the development and in vitro evaluation of a microparticulate system intended for intestine-targeted delivery of curcumin (CRM), a natural polyphenol with anti-inflammatory properties. Microspheres (Ms) based on zein (ZN) and Gantrez(®) AN119 (PVMMA) were prepared by spray-drying and coated with a pH-sensitive polymer (Eudragit(®) FS30D). An experimental design was performed to optimize the microparticulate formulation. A detailed characterization of systems was carried out by SEM, DSC, FTIR, particle size, ζ potential measurements and in vitro CRM release...
December 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28038460/the-comprehensive-therapeutic-effects-of-rectal-surgery-are-better-in-laparoscopy-a-systematic-review-and-meta-analysis
#16
Jiabin Zheng, Xingyu Feng, Zifeng Yang, Weixian Hu, Yuwen Luo, Yong Li
BACKGROUND: Laparoscopic-assisted radical resection of rectal cancer was reported as advantageous compared to laparotomy resection. However, this finding remains controversial, especially given the two recent randomized controlled trials published on The Journal of the American Medical Association (JAMA). OBJECTIVE: To perform a meta-analysis that compares the short-term and long-term outcomes of laparoscopic and open surgery for rectal cancer. DATA SOURCE: To identify clinical trials comparing laparoscopic and open surgery for rectal cancer published by August 2016, we searched the PubMed, Cochrane Library, Springer Link and Clinicaltrials...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035252/signet-ring-colorectal-carcinoma-do-we-need-to-improve-the-treatment-algorithm
#17
Anup Sunil Tamhankar, Parag Ingle, Reena Engineer, Munita Bal, Vikas Ostwal, Avanish Saklani
AIM: To elaborate about this peculiar variant from a tertiary cancer center from India. METHODS: It's a retrospective study (2011-2014) of all patients diagnosed with signet ring colo-rectal cancer (SRCC). Various clinico-pathological variables were studied. RESULTS: One hundred and seventy consecutive patients with SRCC were diagnosed (11.4% of all colorectal cancers). Median Age of the cohort was 41 years. Most common location was recto-sigmoid area (54...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28029540/use-of-a-booster-dose-of-capsular-group-c-meningococcal-glycoconjugate-vaccine-to-demonstrate-immunologic-memory-in-children-primed-with-one-or-two-vaccine-doses-in-infancy
#18
David Pace, Ameneh Khatami, Simon Attard-Montalto, Merryn Voysey, Adam Finn, Saul N Faust, Paul T Heath, Ray Borrow, Matthew D Snape, Andrew J Pollard
BACKGROUND: Use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group C meningococcal conjugate vaccines (MenCC) risks induction of immunologic hyporesponsiveness. For this reason, MenCC vaccines are now used as probes of immunologic memory, however, no studies have demonstrated their ability to distinguish primed from unprimed children. METHODS: This study was part of a randomised controlled trial investigating the immunogenicity of a booster dose of the combined Haemophilus influenzae type b and MenC-tetanus toxoid vaccine (Hib-MenC-TT) in infants receiving reduced dose MenCC vaccine priming schedules (one MenC-CRM/MenC-TT or two MenC-CRM vaccine doses) compared with an unprimed group...
October 28, 2016: Vaccine
https://www.readbyqxmd.com/read/28028288/a-cost-effectiveness-analysis-of-self-debriefing-versus-instructor-debriefing-for-simulated-crises-in-perioperative-medicine-in-canada
#19
Wanrudee Isaranuwatchai, Fahad Alam, Jeffrey Hoch, Sylvain Boet
PURPOSE: High-fidelity simulation training is effective for learning crisis resource management (CRM) skills, but cost is a major barrier to implementing high-fidelity simulation training into the curriculum. The aim of this study was to examine the cost-effectiveness of self-debriefing and traditional instructor debriefing in CRM training programs and to calculate the minimum willingness-to-pay (WTP) value when one debriefing type becomes more cost-effective than the other. METHODS: This study used previous data from a randomized controlled trial involving 50 anesthesiology residents in Canada...
2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28025240/safety-of-quadrivalent-meningococcal-conjugate-vaccine-in-11-to-21-year-olds
#20
Hung-Fu Tseng, Lina S Sy, Bradley K Ackerson, Rulin C Hechter, Sara Y Tartof, Mendel Haag, Jeffrey M Slezak, Yi Luo, Christine A Fischetti, Harp S Takhar, Yan Miao, Marianne Cunnington, Zendi Solano, Steven J Jacobsen
BACKGROUND: Meningococcal conjugate vaccination is recommended in the United States. This study evaluates the safety of quadrivalent meningococcal conjugate vaccine in a cohort aged 11 to 21 years. METHODS: This cohort study with self-controlled case-series analysis was conducted at Kaiser Permanente Southern California. Individuals receiving MenACWY-CRM, a quadrivalent meningococcal conjugate vaccine, during September 30, 2011 to June 30, 2013, were included. Twenty-six prespecified events of interest (EOIs), including neurologic, rheumatologic, hematologic, endocrine, renal, pediatric, and pediatric infectious disease EOIs, were identified through electronic health records 1 year after vaccination...
January 2017: Pediatrics
keyword
keyword
14430
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"