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https://www.readbyqxmd.com/read/27918383/etiology-of-acute-otitis-media-in-children-less-than-5-years-of-age-a-pooled-analysis-of-10-similarly-designed-observational-studies
#1
Melissa K Van Dyke, Jean-Yves Pirçon, Robert Cohen, Shabir A Madhi, Andrés Rosenblüt, Mercedes Macias Parra, Khalid Al-Mazrou, Gerhard Grevers, Pio Lopez, Laura Naranjo, Felix Pumarola, Nuntigar Sonsuwan, William P Hausdorff
BACKGROUND: Acute otitis media (AOM) is an important cause of childhood morbidity and antibiotic prescriptions. However, the relative importance of the well-known otopathogens, Streptococcus pneumoniae (Spn) and Haemophilus influenzae (Hflu), remains unclear due to a limited number of tympanocentesis-based studies that vary significantly in populations sampled, case definitions, and heptavalent pneumococcal conjugate vaccine (PCV7-CRM) use. METHODS: We conducted a pooled analysis of results from ten AOM etiology studies of similar design the protocols of which were derived from a common protocol and conducted in children 3 months to 5 years of age in different countries...
November 30, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27914031/a-simple-spectrofluorimetric-method-for-iron-determination-with-a-chalcone-based-schiff-base
#2
Nurhayat Özbek, Hakan Alp, Gonca Çelik, Tuğba Ak, Osman Can Çağılcı, Nurettin Yaylı, Ümmühan Ocak, Miraç Ocak
A chalcone-based Schiff base (5), capable of detecting iron (III) in partially aqueous media, has been designed, then synthesized by the condensation of 3-formyl-2-hydroxyquinoline and acetophenone. To determine iron (III) ion, a simple spectrofluorimetric method was developed by using the synthesized Schiff base. The developed method was validated by analyzing the certified reference material (CRM-SA-C Sandy Soil C). During the process of the determination of iron in food samples, satisfactory accuracy was obtained for spinach and rocket...
December 2, 2016: Journal of Fluorescence
https://www.readbyqxmd.com/read/27912986/a-phase-iii-observer-blind-randomized-controlled-study-to-evaluate-the-immune-response-and-the-correlation-with-nasopharyngeal-carriage-after-immunization-of-university-students-with-a-quadrivalent-meningococcal-acwy-glycoconjugate-or-serogroup-b-meningococcal
#3
Robert C Read, Peter Dull, Xilian Bai, Kate Nolan, Jamie Findlow, Rohit Bazaz, Annett Kleinschmidt, Maggie McCarthy, Huajun Wang, Daniela Toneatto, Ray Borrow
BACKGROUND: University students have high rates of pharyngeal carriage of Neisseria meningitidis. Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal serogroups B and ACWY respectively in younger age groups, and also to elicit a modest impact on meningococcal carriage in vaccinated students. However, vaccine responses in university students and the impact of serum bactericidal antibody (SBA) titers on meningococcal carriage are undetermined...
November 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27910581/spectral-survey-of-helium-lines-in-a-linear-plasma-device-for-use-in-helios-imaging
#4
H B Ray, T M Biewer, D T Fehling, R C Isler, E A Unterberg
Fast visible cameras and a filterscope are used to examine the visible light emission from Oak Ridge National Laboratory's Proto-MPEX. The filterscope has been configured to perform helium line ratio measurements using emission lines at 667.9, 728.1, and 706.5 nm. The measured lines should be mathematically inverted and the ratios compared to a collisional radiative model (CRM) to determine Te and ne. Increasing the number of measurement chords through the plasma improves the inversion calculation and subsequent Te and ne localization...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27896813/transcriptional-and-post-transcriptional-regulation-of-histone-variant-h2a-z-during-sea-urchin-development
#5
Mihai Hajdu, Jasmine Calle, Andrea Puno, Aminat Haruna, César Arenas-Mena
Histone variant H2A.Z promotes chromatin accessibility at transcriptional regulatory elements and is developmentally regulated in metazoans. We characterize the transcriptional and post-transcriptional regulation of H2A.Z in the purple sea urchin Strongylocentrotus purpuratus. H2A.Z depletion by antisense translation-blocking morpholino oligonucleotides during early development causes developmental collapse, in agreement with its previously demonstrated general role in transcriptional multipotency. During H2A...
November 29, 2016: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/27868209/determination-of-lithium-and-transition-metals-in-li1-ni1-3-co1-3-mn1-3-o2-ncm-cathode-material-for-lithium-ion-batteries-by-capillary-electrophoresis
#6
Britta Vortmann-Westhoven, Constantin Lürenbaum, Martin Winter, Sascha Nowak
In this work we present a novel electrophoretic method that was developed for the determination of lithium and transition metals in LiNi1/3 Co1/3 Mn1/3 O2 (NCM) cathode material after microwave digestion. The cations in the digested NCM material was separated by capillary electrophoresis (CE) and the element content was determined by UV/Vis detection. To characterize the precision of the measurements, the relative standard deviations (RSD) and concentrations were calculated and compared to those obtained with inductively coupled plasma - optical emission spectrometry (ICP-OES)...
November 21, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27853973/clinical-outcomes-and-case-volume-effect-of-transanal-total-mesorectal-excision-for-rectal-cancer-a-systematic-review
#7
REVIEW
C L Deijen, A Tsai, T W A Koedam, M Veltcamp Helbach, C Sietses, A M Lacy, H J Bonjer, J B Tuynman
Transanal total mesorectal excision (TaTME) has been developed to improve quality of TME for patients with mid and low rectal cancer. However, despite enthusiastic uptake and teaching facilities, concern exists for safe introduction. TaTME is a complex procedure and potentially a learning curve will hamper clinical outcome. With this systematic review, we aim to provide data regarding morbidity and safety of TaTME. A systematic literature search was performed in MEDLINE (PubMed), EMBASE (Ovid) and Cochrane Library...
November 16, 2016: Techniques in Coloproctology
https://www.readbyqxmd.com/read/27834823/multilevel-safety-climate-and-safety-performance-in-the-construction-industry-development-and-validation-of-a-top-down-mechanism
#8
Ran Gao, Albert P C Chan, Wahyudi P Utama, Hafiz Zahoor
The character of construction projects exposes front-line workers to dangers and accidents. Safety climate has been confirmed to be a predictor of safety performance in the construction industry. This study aims to explore the underlying mechanisms of the relationship between multilevel safety climate and safety performance. An integrated model was developed to study how particular safety climate factors of one level affect those of other levels, and then affect safety performance from the top down. A questionnaire survey was administered on six construction sites in Vietnam...
November 8, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27830316/a-mussel-tissue-certified-reference-material-for-multiple-phycotoxins-part-4-certification
#9
Pearse McCarron, Elliott Wright, Håkan Emteborg, Michael A Quilliam
A freeze-dried mussel tissue (Mytilus edulis) reference material (CRM-FDMT1) was produced containing multiple groups of shellfish toxins. Homogeneity and stability testing showed the material to be fit for purpose. The next phase of work was to assign certified values and uncertainties to 10 analytes from six different toxin groups. Efforts involved optimizing extraction procedures for the various toxin groups and performing measurements using liquid chromatography-based analytical methods. A key aspect of the work was compensating for matrix effects associated with liquid chromatography-mass spectrometry through standard addition, dilution, or matrix-matched calibration...
November 9, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27829942/safety-and-usefulness-of-needle-guided-resection-of-levator-muscles-in-laparoscopic-abdominoperineal-resection-for-low-rectal-cancer
#10
Takehito Yamamoto, Akiyoshi Kanazawa, Hiroyuki Matsubara, Takuya Okamoto
INTRODUCTION: During laparoscopic abdominoperineal resection (APR) for low rectal cancer, it is difficult to resect the levator muscles and remove a cylindrical specimen without venturing close to the rectal wall to ensure negative circumferential resection margins (CRM). To solve this problem, we developed a needle-guided, laparoscopic, abdominoperineal resection (LAPR) technique. AIM: To present the safety and superiority of our technique, "needle-guided LAPR"...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27819636/the-importance-of-preoperative-stadialization-of-rectal-cancer-using-multiparametric-mri-a-systematic-review
#11
Ferdinand Bauer
A correct preoperative stadialization of rectal carcinoma has a direct influence upon its therapeutic strategy, resulting in a significant improvement of the survival rate and life quality after the treatment. The therapeutic strategy refers to the option of undergoing or not preoperative radiochemotherapy before the total mesorectal excision (TME). The technical advances in the magnetic resonance domain makes possible the multiparametric examinations (mp MRI) with medical equipments (3T models are common) good enough to obtain images having an excellent quality, which allow a correct diagnosis of the local tumour spread...
2016: Chirurgia
https://www.readbyqxmd.com/read/27811836/recommendations-for-use-of-meningococcal-conjugate-vaccines-in-hiv-infected-persons-advisory-committee-on-immunization-practices-2016
#12
Jessica R MacNeil, Lorry G Rubin, Monica Patton, Ismael R Ortega-Sanchez, Stacey W Martin
At its June 2016 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended routine use of meningococcal conjugate vaccine (serogroups A, C, W, and Y; including MenACWY-D [Menactra, Sanofi Pasteur] or MenACWY-CRM [Menveo, GlaxoSmithKline]) for persons aged ≥2 months with human immunodeficiency virus (HIV) infection. ACIP has previously recommended routine vaccination of persons aged ≥2 months who have certain medical conditions that increase risk for meningococcal disease (1), including persons who have persistent (e...
November 4, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27810751/concentric-ring-method-for-generating-pollen-maps-quercus-as-case-study
#13
Jose Oteros, Rosa Mª Valencia, Sara Del Río, Ana Mª Vega, Herminia García-Mozo, Carmen Galán, Pablo Gutiérrez, Paolo Mandrioli, Delia Fernández-González
Mapping pollen concentrations is of great interest to study the health impact and ecological implications or for forestry or agronomical purposes. A deep knowledge about factors affecting airborne pollen is essential for predicting and understanding its dynamics. The present work sought to predict annual Quercus pollen over the Castilla and León region (Central and Northern Spain). Also to understand the relationship between airborne pollen and landscape. Records of Quercus and Quercus pyrenaica pollen types were collected at 13 monitoring sites over a period of 8years...
October 27, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27798279/label-free-in-situ-imaging-of-oil-body-dynamics-and-chemistry-in-germination
#14
Gustav Waschatko, Nils Billecke, Sascha Schwendy, Henriette Jaurich, Mischa Bonn, Thomas A Vilgis, Sapun H Parekh
Plant oleosomes are uniquely emulsified lipid reservoirs that serve as the primary energy source during seed germination. These oil bodies undergo significant changes regarding their size, composition and structure during normal seedling development; however, a detailed characterization of these oil body dynamics, which critically affect oil body extractability and nutritional value, has remained challenging because of a limited ability to monitor oil body location and composition during germination in situ Here, we demonstrate via in situ, label-free imaging that oil bodies are highly dynamic intracellular organelles that are morphologically and biochemically remodelled extensively during germination...
October 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27789563/reduction-in-unnecessary-ventricular-pacing-fails-to-affect-hard-clinical-outcomes-in-patients-with-preserved-left-ventricular-function-a-meta-analysis
#15
Mohammed Shurrab, Jeff S Healey, Saleem Haj-Yahia, Anna Kaoutskaia, Giuseppe Boriani, Aldo Carrizo, Gianluca Botto, David Newman, Luigi Padeletti, Stuart J Connolly, Eugene Crystal
AIMS: Several pacing modalities across multiple manufacturers have been introduced to minimize unnecessary right ventricular pacing. We conducted a meta-analysis to assess whether ventricular pacing reduction modalities (VPRM) influence hard clinical outcomes in comparison to standard dual-chamber pacing (DDD). METHODS AND RESULTS: An electronic search was performed using Cochrane Central Register, PubMed, Embase, and Scopus. Only randomized controlled trials (RCT) were included in this analysis...
October 26, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27789088/sewage-sludge-ash-ssa-from-large-and-small-incineration-plants-as-a-potential-source-of-phosphorus-polish-case-study
#16
REVIEW
Marzena Smol, Joanna Kulczycka, Zygmunt Kowalski
The aim of this research is to present the possibility of using the sewage sludge ash (SSA) generated in incineration plants as a secondary source of phosphorus (P). The importance of issues related to P recovery from waste materials results from European Union (UE) legislation, which indicated phosphorus as a critical raw material (CRM). Due to the risks of a shortage of supply and its impact on the economy, which is greater than other raw materials, the proper management of phosphorus resources is required in order to achieve global P security...
October 24, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27782396/phenyl-glycolipids-with-different-glycosyl-groups-exhibit-marked-differences-in-murine-and-human-inkt-cell-activation
#17
Tai-Na Wu, Kun-Hsien Lin, Ying-Ta Wu, Jing-Rong Huang, Jung-Tung Hung, Jen-Chine Wu, Chien-Yu Chen, Kuo-Ching Chu, Nan-Horng Lin, Alice L Yu, Chi-Huey Wong
Glycosphingolipids (GSLs) bearing the α-galactosyl head group and the acyl chain terminated with a phenyl derivative were found to be more potent than α-galactosyl ceramide (αGalCer) to stimulate both murine and human invariant natural killer T (iNKT) cells and to induce antibody isotope switch to IgG. In this study, we replaced the galactosyl group with glucose (αGlc) and its fluoro-analogs, and found that phenyl GSLs with αGlc (C34-Glc) and its fluoro-analog 6F-C34-Glc were stronger than those with αGal in stimulating human iNKT cells but weaker in mice...
October 26, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27779871/elemental-quantification-and-residues-characterisation-of-wet-digested-certified-and-commercial-carbon-materials
#18
Filipa R Fernandes Simoes, Nitin Kumar Batra, Bashir H Warsama, Christian G Canlas, Shashikant Pandurang Patole, Tahir F Yapici, Pedro M F J Costa
Inductively coupled plasma optical emission spectroscopy (ICP-OES) is a common, relatively low cost and straightforward analytical technique for the study of trace quantities of metals in solid materials but its applicability to nanocarbons (e.g. graphene and nanotubes) has suffered from the lack of efficient digestion steps and certified reference materials (CRM). Here, various commercial and certified graphitic carbon materials were subjected to a "two-steps" microwave-assisted acid digestion procedure and the concentration of up to 18 elements was analysed by ICP-OES...
October 25, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27769418/calibration-of-handheld-x-ray-fluorescence-xrf-equipment-for-optimum-determination-of-elemental-concentrations-in-sediment-samples
#19
K Gabriela Mejía-Piña, Miguel Angel Huerta-Diaz, O González-Yajimovich
Handheld X-ray fluorescence spectrometers (XRFs) represent a more practical, efficient and economic tool to determine the elemental composition of solid inorganic and organic samples than conventional analytical techniques. The objective of this work was to demonstrate that handheld XRFs could be a precise, accurate and reliable tool to analyze up to 27 different elements. This objective was accomplished through the optimization of an empirical calibration curve that, in addition to include certified reference materials (CRM), it also introduced new approaches, such as the use of solid CRM mixtures and combinations of organic and inorganic matrices...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27769375/species-specific-isotope-dilution-for-the-accurate-and-si-traceable-determination-of-arsenobetaine-and-methylmercury-in-cuttlefish-and-prawn
#20
Paramee Kumkrong, Benjaporn Thiensong, Phuong Mai Le, Garnet McRae, Anthony Windust, Suladda Deawtong, Juris Meija, Paulette Maxwell, Lu Yang, Zoltán Mester
Methods based on species specific isotope dilution were developed for the accurate and SI traceable determination of arsenobetaine (AsBet) and methylmercury (MeHg) in prawn and cuttlefish tissues by LC-MS/MS and SPME GC-ICPMS. Quantitation of AsBet and MeHg were achieved by using a (13)C-enriched AsBet spike (NRC CRM CBET-1) and an enriched spike of Me(198)Hg (NRC CRM EMMS-1), respectively, wherein analyte mass fractions in enriched spikes were determined by reverse isotope dilution using natural abundance AsBet and MeHg primary standards...
November 2, 2016: Analytica Chimica Acta
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