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https://www.readbyqxmd.com/read/29329168/immune-responses-to-booster-vaccination-with-meningococcal-abcwy-vaccine-following-primary-vaccination-with-either-investigational-or-licensed-vaccines-a-phase-2-randomized-study
#1
Leszek Szenborn, Stan L Block, Teresa Jackowska, Ryszard Konior, Diego DʼAgostino, Igor Smolenov, Daniela Toneatto, Jo Anne Welsch
BACKGROUND: Current meningococcal prime-boost vaccination schedules include separate vaccines for serogroups ACWY and B. An investigational combined serogroups ABCWY vaccine (MenABCWY) was developed to protect against clinically important Neisseria meningitidis serogroups. METHODS: In this phase 2, randomized, observer-blind, extension study (NCT01272180), participants aged 10-25 years received 1 booster dose of MenABCWY vaccine at 24 months (M) post-primary series of either MenABCWY (2 doses), 4CMenB (2 doses) or MenACWY-CRM vaccine (1 dose)...
January 11, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29321920/impact-of-medial-to-lateral-vs-lateral-to-medial-approach-on-short-term-and-cancer-related-outcomes-in-laparoscopic-colorectal-surgery-a-retrospective-cohort-study
#2
Anwar Hussain, Fahad Mahmood, Andrew W Torrance, Achilleas Tsiamis
Background: Laparoscopic surgery is the favoured method of colorectal cancer resections. It is surgeon expertise and discretion to choose whether to mobilize colon lateral-to-medial or medial-to-lateral. We aim to identify the advantage of one approach over the other in short-term and cancerrelated outcomes. Methods: A retrospective review of a prospectively maintained database of all laparoscopic colorectal resections with curative-intent, in a single unit, from March 2013 to October 2014...
February 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29310314/determination-of-silicon-in-biomass-and-products-of-pyrolysis-process-via-high-resolution-continuum-source-atomic-absorption-spectrometry
#3
Flávio V Nakadi, Caroline Prodanov, Wiliam Boschetti, Maria Goreti R Vale, Bernhard Welz, Jailson B de Andrade
Thermochemical processes can convert the biomass into fuels, such as bio-oil. The biomass submitted to pyrolysis process, such as fibers, are generally rich in silicon, an element that can lead to damages in an engine when there is high concentration in a fuel. High-resolution continuum source atomic absorption spectrometry (HR-CS AAS) is an interesting alternative for Si determination in the products and byproducts of the pyrolysis process because, besides the flame (F) and graphite furnace (GF) atomizers, it has enhanced the application of direct analysis of solid samples (SS) within GF...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29298348/computational-exploration-of-cis-regulatory-modules-in-rhythmic-expression-data-using-the-exploration-of-distinctive-cres-and-crms-edcc-and-crm-network-generator-cng-programs
#4
Pavlos Stephanos Bekiaris, Tobias Tekath, Dorothee Staiger, Selahattin Danisman
Understanding the effect of cis-regulatory elements (CRE) and clusters of CREs, which are called cis-regulatory modules (CRM), in eukaryotic gene expression is a challenge of computational biology. We developed two programs that allow simple, fast and reliable analysis of candidate CREs and CRMs that may affect specific gene expression and that determine positional features between individual CREs within a CRM. The first program, "Exploration of Distinctive CREs and CRMs" (EDCC), correlates candidate CREs and CRMs with specific gene expression patterns...
2018: PloS One
https://www.readbyqxmd.com/read/29287413/extraction-and-preconcentration-of-trace-al-and-cr-from-vegetable-samples-by-vortex-assisted-ionic-liquid-based-dispersive-liquid-liquid-microextraction-prior-to-atomic-absorption-spectrometric-determination
#5
Nail Altunay, Emre Yıldırım, Ramazan Gürkan
In the study, a simple, and efficient microextraction approach, which is termed as vortex-assisted ionic liquid-based dispersive liquid-liquid microextraction (VA-IL-DLLME), was developed for flame atomic absorption spectrometric analysis of aluminum (Al) and chromium (Cr) in vegetables. The method is based on the formation of anionic chelate complexes of Al(III) and Cr(VI) with o-hydroxy azo dye, at pH 6.5, and then extraction of the hydrophobic ternary complexes formed in presence of cetyltrimethylammonium bromide (CTAB) into a 125 μL volume of 1-butyl-3-methylimidazolium bis(trifluorosulfonyl)imide [C4mim][Tf2N]) as extraction solvent...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29274420/multi-analysis-of-chemical-transformations-of-lignin-macromolecules-from-waterlogged-archaeological-wood
#6
Yan Xia, Tian-Ying Chen, Jia-Long Wen, Yi-Li Zhao, Jian Qiu, Run-Cang Sun
A large number of archaeological wooden building poles have been excavated from the Hai Menkou site (Yunnan province, China). Lignin can be transformed and altered accompanied with significant loss of carbohydrates during this process. Elucidation of chemical and structural transformations of lignin is of primary importance for understanding both the nature of degradation processes and the structure of waterlogged archaeological wood, and crucial for developing proper consolidation technology and restoring artifacts of historical and cultural value...
December 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29274230/crispr-cas9-and-active-genetics-based-trans-species-replacement-of-the-endogenous-drosophilakni-l2-crm-reveals-unexpected-complexity
#7
Xiang-Ru Shannon Xu, Valentino Matteo Gantz, Natalia Siomava, Ethan Bier
The knirps (kni) locus encodes transcription factors required for induction of the L2 wing vein in Drosophila. Here, we employ diverse CRISPR/Cas9 genome editing tools to generate a series of targeted lesions within the endogenous cis-regulatory module (CRM) required for kni expression in the L2 vein primordium. Phenotypic analysis of these 'in locus' mutations based on both expression of Kni protein and adult wing phenotypes, reveals novel unexpected features of L2-CRM function including evidence for a chromosome pairing-dependent process that promotes transcription...
December 23, 2017: ELife
https://www.readbyqxmd.com/read/29260109/a-case-of-congenital-retinal-macrovessel-in-an-otherwise-normal-eye
#8
Margaret R Strampe, William J Wirostko, Joseph Carroll
Purpose: To present the case of a 37-year-old female with a foveal macrovessel. Observations: The patient had an incidental finding of congenital retinal macrovessel (CRM) in the left eye on optical coherence tomography (OCT). Visual acuity was normal, and slit lamp and dilated fundus examinations were otherwise unremarkable. OCT angiography (OCTA) imaging allowed for visualization of the depth profile of the vessel as well as the foveal avascular zone (FAZ). The FAZ and foveal pit were both smaller in the affected eye compared to the fellow eye...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29232537/laparoscopic-versus-conventional-open-surgery-in-intersphincteric-resection-for-low-rectal-cancer-a-systematic-review-and-meta-analysis
#9
Xubing Zhang, Qingbin Wu, Tao Hu, Chaoyang Gu, Liang Bi, Ziqiang Wang
AIM: This meta-analysis aims at comparing laparoscopic intersphincteric resection (LISR) with conventional open ISR (OISR) for low rectal cancer (LRC) in terms of intraoperative, postoperative, pathological, and survival outcomes. MATERIALS AND METHODS: A systematic literature search with no limits was performed in PubMed and Ovid. The last search was performed on May 27, 2017. The outcomes of interests included intraoperative outcomes: operative time and blood loss; postoperative outcomes: hospital day, postoperative hospital day, time to first flatus, time to normal diet, ileus, intra-abdominal abscess, anastomotic leakage, anastomotic stricture, wound infection, pneumonia, urinary complication, morbidity, and mortality; pathological outcomes: lymph node harvested, R0 resection rate, distance of proximal resection margin, distal resection margin and circumferential resection margin (CRM), and positive CRM; survival outcomes: 3-year overall survival (OS), 3-year disease-free survival (DFS), 5-year OS, and 5-year DFS...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29228455/prognostic-significance-of-neoadjuvant-rectal-score-in-locally-advanced-rectal-cancer-after-neoadjuvant-chemoradiotherapy-and-construction-of-a-prediction-model
#10
Yanwu Sun, Yiyi Zhang, Xuejing Wu, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
AIM: To evaluate the prognostic significance of neoadjuvant rectal (NAR) score after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC), and to develop a nomogram predicting disease-free survival (DFS). METHOD: A total of 522 LARC patients undergoing nCRT and surgery were included. NAR scores were calculated using the equation [5pN-3(cT-pT) + 12]^2/9.61, and classified as low (<8), intermediate (8-16), and high (>16). Clinicopathological and survival outcomes were compared...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29225023/origins-and-specification-of-the-drosophila-wing
#11
David Requena, Jose Andres Álvarez, Hugo Gabilondo, Ryan Loker, Richard S Mann, Carlos Estella
The insect wing is a key evolutionary innovation that was essential for insect diversification. Yet despite its importance, there is still debate about its evolutionary origins. Two main hypotheses have been proposed: the paranotal hypothesis, which suggests that wings evolved as an extension of the dorsal thorax, and the gill-exite hypothesis, which proposes that wings were derived from a modification of a pre-existing branch at the dorsal base (subcoxa) of the leg. Here, we address this question by studying how wing fates are initially specified during Drosophila embryogenesis, by characterizing a cis-regulatory module (CRM) from the snail (sna) gene, sna-DP (for dorsal primordia)...
November 30, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29221296/prognostic-role-of-initial-pan-endoscopic-tumor-length-at-diagnosis-in-operable-esophageal-squamous-cell-carcinoma-undergoing-esophagectomy-with-or-without-neoadjuvant-concurrent-chemoradiotherapy
#12
Chen-Sung Lin, Chao-Yu Liu, Chih-Tao Cheng, Yu-Chen Tsai, Lun-Wei Chiou, Ming-Yuan Lee, Chia-Chuan Liu, Chih-Hsun Shih
Background: The objective of this study was to appraise the prognostic role of initial pan-endoscopic tumor length at diagnosis within or between operable esophageal squamous cell carcinoma (ESCC) undergoing upfront esophagectomy or neoadjuvant concurrent chemoradiotherapy (nCCRT) followed by esophagectomy. Methods: Between Jan 2001 and Dec 2013 in Koo-Foundation Sun Yat-sen Cancer Center in Taiwan, 101 ESCC patients who underwent upfront esophagectomy (surgery group) and 128 nCCRT followed by esophagectomy (nCCRT-surgery group) were retrospectively collected...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29208528/heterochromatin-protein-hp-1%C3%AE-is-not-only-in-the-nucleus-but-also-in-the-cytoplasm-interacting-with-actin-in-both-cell-compartments
#13
Nancy L Charó, Natalia M Galigniana, Graciela Piwien-Pilipuk
Confocal and electron microscopy images, and WB analysis of cellular fractions revealed that HP1γ is in the nucleus but also in the cytoplasm of C2C12 myoblasts, myotubes, skeletal and cardiac muscles, N2a, HeLa and HEK293T cells. Signal specificity was tested with different antibodies and by HP1γ knockdown. Leptomycin B treatment of myoblasts increased nuclear HP1γ, suggesting that its nuclear export is Crm-1-dependent. HP1γ exhibited a filamentous pattern of staining partially co-localizing with actin in the cytoplasm of myotubes and myofibrils...
February 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29208050/robotic-assisted-total-mesorectal-excision-with-the-single-docking-technique-for-patients-with-rectal-cancer
#14
Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Wei-Chih Su, Ming-Yii Huang, Chun-Ming Huang, Yu-Tang Chang, Jaw-Yuan Wang
BACKGROUND: The robotic system has advantages of high-definition three-dimensional vision and articular instruments with high dexterity, allowing more precise dissection in the deep and narrow pelvic cavity. METHODS: We enrolled 95 patients with stage I-III rectal cancer (adenocarcinoma) who underwent totally robotic-assisted total mesorectal excision (TME) with single-docking technique at a single institution between September 2013 and December 2016. RESULTS: Of the 95 patients, 48 (50...
December 5, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29203979/young-vs-old-colorectal-cancer-in-indian-subcontinent-a-tertiary-care-center-experience
#15
Ashish B Pokharkar, Manish Bhandare, Prachi Patil, Shaesta Mehta, Reena Engineer, Avanish P Saklani
This study aims to compare patient, tumor, treatment-related factors and survival between young (<45 years) and old (>45 years) Indian colorectal cancer (CRC) patients. Total 778 patients of CRC were registered at tertiary cancer center in India between 1 August 2013 and 31 July 2014. Patients were followed up for median period of 27.73 months. Data regarding patient, tumor, treatment and survival-related factors were collected. Patients were divided in young (≤45 years) and old (>45 years) age groups...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203976/laparoscopic-versus-open-approach-for-intersphincteric-resection-results-from-a-tertiary-cancer-center-in-india
#16
Vishwas D Pai, Pavan Sugoor, Prachi S Patil, Vikas Ostwal, Reena Engineer, Supreeta Arya, Ashwin Desouza, Avanish P Saklani
The study aims to compare open intersphincteric resection (OISR) with laparoscopic intersphincteric resection (LISR) in terms of short-term oncological and clinical outcomes. This is a retrospective review of a prospectively maintained database including all the patients of rectal cancer who underwent intersphincteric resection (ISR) at Tata Memorial Centre between 1st July 2013 and 30th November 2015. Short-term oncological parameters evaluated included circumferential resection margin involvement (CRM), distal resection margin involvement, and number of nodes harvested...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203975/a-prospective-study-of-distal-microscopic-spread-in-rectal-cancer-after-neoadjuvant-chemoradiation-in-pinned-and-unpinned-specimen
#17
Aravind S Kapali, K Chandramohan, A V Jayasudha
The most important margin in determining the prognosis of rectal cancer is circumferential resection margin (CRM). But, the type of surgery is determined by distal rectal margin (DRM), whether sphincter saving procedure is possible or patient needs an abdominoperineal resection. There are no standardized uniform guidelines for measurement of DRM. The purpose of this study is to assess the distal microscopic spread beyond gross margin after neoadjuvant concurrent chemoradiation (CCRT) in rectal cancers, the factors influencing the distal microscopic spread, the shrinkage of the distal margin in pinned and unpinned fresh and fixed specimen, and to find out the best method of measurement of distal rectal margin...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29201476/multimodal-imaging-analysis-in-a-case-with-congenital-fovea-involving-retinal-macrovessel-and-excellent-visual-acuity
#18
Vishal Shah, M Ashwin Reddy, Vasilios P Papastefanou
Purpose: Congenital retinal macrovessels (CRM) represent rare aberrant vasculature of the retinal vessels that can supply or drain the macula. In this report, the optical coherence tomography angiography features of a congenital retinal macrovessel are discussed. Methods: The history and examination findings are presented alongside swept-source OCT angiography with corresponding B scan and en face OCT imaging. Patients: The case is a 12-year-old female patient with excellent best-corrected visual acuity in both eyes...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29200934/sparse-graphs-using-exchangeable-random-measures
#19
François Caron, Emily B Fox
Statistical network modelling has focused on representing the graph as a discrete structure, namely the adjacency matrix. When assuming exchangeability of this array-which can aid in modelling, computations and theoretical analysis-the Aldous-Hoover theorem informs us that the graph is necessarily either dense or empty. We instead consider representing the graph as an exchangeable random measure and appeal to the Kallenberg representation theorem for this object. We explore using completely random measures (CRMs) to define the exchangeable random measure, and we show how our CRM construction enables us to achieve sparse graphs while maintaining the attractive properties of exchangeability...
November 2017: Journal of the Royal Statistical Society. Series B, Statistical Methodology
https://www.readbyqxmd.com/read/29191924/both-autocrine-signaling-and-paracrine-signaling-of-hb-egf-enhance-ocular-neovascularization
#20
Yuki Inoue, Masamitsu Shimazawa, Shinsuke Nakamura, Shinsuke Takata, Yuhei Hashimoto, Hiroshi Izawa, Tomomi Masuda, Kazuhiro Tsuruma, Tomohisa Sakaue, Hironao Nakayama, Shigeki Higashiyama, Hideaki Hara
OBJECTIVE: The incidence of blindness is increasing because of the increase in abnormal ocular neovascularization. Anti-VEGF (vascular endothelial growth factor) therapies have led to good results, although they are not a cure for the blindness. The purpose of this study was to determine what role HB-EGF (heparin-binding epidermal growth factor-like growth factor) plays in ocular angiogenesis. APPROACH AND RESULTS: We examined the role played by HB-EGF in ocular neovascularization in 2 animal models of neovascularization: laser-induced choroidal neovascularization (CNV) and oxygen-induced retinopathy...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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