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https://www.readbyqxmd.com/read/29786037/preliminary-outcome-of-individualized-abdominoperineal-excision-for-locally-advanced-low-rectal-cancer
#1
Yi Zheng, Jia-Gang Han, Zhen-Jun Wang, Zhi-Gang Gao, Guang-Hui Wei, Zhi-Wei Zhai, Bao-Cheng Zhao
Background: The introduction of individualized abdominoperineal excision (APE) may minimize operative trauma and reduce the rate of complications. The purpose of this study was to evaluate the safety and efficacy of individualized APE for low rectal cancer. Methods: Fifty-six patients who underwent individualized APE from June 2011 to June 2015 were evaluated retrospectively in Beijing Chaoyang Hospital, Capital Medical University. The main outcome measures were circumferential resection margin (CRM) involvement, intraoperative perforation, postoperative complications, and local recurrence...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29775655/confocal-raman-microspectroscopy-as-an-alternative-to-differential-scanning-calorimetry-to-detect-the-impact-of-emulsifiers-and-formulations-on-stratum-corneum-lipid-conformation
#2
Ziwei Zhang, Dominique Jasmin Lunter
The purpose of this study was to investigate the impact of emulsifiers and formulations on stratum corneum (SC) lipid conformation and evaluate confocal Raman microspectroscopy (CRM) as an alternative method to differential scanning calorimetry (DSC) in this research context. To this end, four different formulations were used: three conventional creams that contained ionic and/or non-ionic emulsifiers and one surfactants-free emulsion stabilized by a polymeric emulsifier. Additionally, all emulsifiers were tested in aqueous solutions/dispersions in the respective concentrations as present in the formulations...
May 15, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29769209/time-to-event-bayesian-optimal-interval-design-to-accelerate-phase-i-trials
#3
Ying Yuan, Ruitao Lin, Daniel Li, Lei Nie, Katherine E Warren
Late-onset toxicity is common for novel molecularly targeted agents and immunotherapy. It causes major logistic difficulty for existing adaptive phase I trial designs, which require the observance of toxicity early enough to apply dose escalation rules for new patients. The same logistic difficulty arises when the accrual is rapid. We propose the time-to-event Bayesian optimal interval (TITE-BOIN) design to accelerate phase I trials by allowing for real-time dose assignment decisions for new patients while some enrolled patients' toxicity data are still pending...
May 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#4
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29753141/a-lead-analysis-based-on-amine-functionalized-bimodal-mesoporous-silica-nanoparticles-in-human-biological-samples-by-ultrasound-assisted-ionic-liquid-trap-micro-solid-phase-extraction
#5
Hamid Shirkhanloo, Sara Davari Ahranjani
A simple and applied method based on ultrasound assisted-Ionic liquid trap-micro solid phase extraction (USA-ILT-μSPE) was demonstrated for preconcentration/separation of lead (Pb) in human blood and urine samples. By proposed method, the amine-functionalized bimodal mesoporous silica nanoparticles (NH2 -UVM7 ) as solid phase sorbent was used for lead analysis in human biological samples at pH ≈ 7.0. After shaking/centrifuging of sample, the Pb (II) was extracted with NH2 -UVM7 without any chelating agents, trapped in ionic liquid phase and settled down in conical centrifuge tube as a residual solution [Pb→:NH2 -UVM7 ]...
May 4, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29748929/toxicological-aspect-of-some-selected-medicinal-plant-samples-collected-from-djelfa-algeria-region
#6
Samir Begaa, Mohammed Messaoudi
Instrumental neutron activation analysis (INAA) has been used to determine the concentration of some toxic chemical elements in a variety of aromatic plants samples collected from Djelfa region. In the present work, eight medicinal plants were examined, such as Artemisia herba-alba Asso., Artemisia compestris L., Laurus nobilis L., Origanum vulgare L., Mentha spicata L., Rosmarinus officinalis L., Mentha pulegium L., and Pistacia lentiscus L. The levels of toxic elements were compared to their daily total intake; Arsenic was present in all plant species examined, with a concentration ranging from 0...
May 10, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29737466/clinical-features-of-haff-disease-and-myositis-after-the-consumption-of-boiled-brackish-water-crayfish-a-retrospective-study-of-96-cases-at-a-single-centre
#7
Fei He, Jun Ni, Jun-Ai Huang, Yao Liu, Chao Wu, Jun Wang
The present study describes the difference in clinical features between the patients with Haff disease and crayfish-related myositis (CRM) after crayfish consumption. This was a single-centre, retrospective analysis at the Emergency Department of the Drum Tower Hospital of Nanjing University School of Medicine from July to August of 2016. The baseline information came from the Electronic Medical Record System at the institution. Totally 96 patients were included, of whom 52 patients were confirmed to have Haff disease and 44 patients were CRM...
May 8, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29719622/glucose-transporter-1-expression-as-a-marker-of-prognosis-in-oesophageal-adenocarcinoma
#8
Jaine K Blayney, Lauren Cairns, Gerald Li, Niamh McCabe, Leanne Stevenson, Christopher J Peters, Nathan B Reid, Veronica J Spence, Chintapuza Chisambo, Damian McManus, Jacqueline James, Stephen McQuaid, Stephanie Craig, Kenneth Arthur, Darragh McArt, Chin-Ann J Ong, Pierre Lao-Sirieix, Peter Hamilton, Manuel Salto-Tellez, Martin Eatock, Helen G Coleman, Rebecca C Fitzgerald, Richard D Kennedy, Richard C Turkington
Background: The current TNM staging system for oesophageal adenocarcinoma (OAC) has limited ability to stratify patients and inform clinical management following neo-adjuvant chemotherapy and surgery. Results: Functional genomic analysis of the gene expression data using Gene Set Enrichment Analysis (GSEA) identified GLUT1 as putative prognostic marker in OAC.In the discovery cohort GLUT1 positivity was observed in 114 patients (80.9%) and was associated with poor overall survival (HR 2...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713995/full-protection-against-soman-induced-seizures-and-brain-damage-by-ly293558-and-caramiphen-combination-treatment-in-adult-rats
#9
James P Apland, Vassiliki Aroniadou-Anderjaska, Taiza H Figueiredo, Marcio De Araujo Furtado, Maria F M Braga
Acute exposure to nerve agents induces status epilepticus (SE), which causes brain damage or death. LY293558, an antagonist of AMPA and GluK1 kainate receptors is a very effective anticonvulsant and neuroprotectant against soman; however, some neuronal damage is still present after treatment of soman-exposed rats with LY293558. Here, we have tested whether combining LY293558 with an NMDA receptor antagonist can eliminate the residual damage. For this purpose, we chose caramiphen (CRM), an antimuscarinic compound with NMDA receptor antagonistic properties...
April 30, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29705082/transvenous-extraction-of-advisory-implantable-cardioverter-defibrillator-leads-with-a-relatively-long-implant-duration
#10
Masahiko Goya, Michio Nagashima, Ken-Ichi Hiroshima, Kentaro Hayashi, Yu Makihara, Masato Fukunaga, Yoshimori An, Masatsugu Ohe, Takeshi Sasaki, Shinya Shiohira, Yasuhiro Shirai, Mihoko Kawabata, Kenji Ando, Mitsuaki Isobe, Kenzo Hirao
BACKGROUND: Optimal management of advisory implantable cardioverter defibrillator (ICD) leads has not been established. Several studies were reported concerning the lead extraction of advisory ICD leads, but the implant duration of those studies was short. We estimated the efficacy of lead extractions of advisory ICD leads with a relatively longer duration in Japanese patients. METHODS: We retrospectively analyzed 28 patients who underwent a lead extraction at Kokura Memorial Hospital and Tokyo Medical and Dental University Hospital [Fidelis (Medtronic, Minneapolis, MN, USA): n=19, Riata (St...
April 25, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29687427/ceria-nanoparticles-deposited-on-graphene-nanosheets-for-adsorption-of-copper-ii-and-lead-ii-ions-and-of-anionic-species-of-arsenic-and-selenium
#11
Anna Baranik, Anna Gagor, Ignasi Queralt, Eva Marguí, Rafal Sitko, Beata Zawisza
A nanocomposite prepared from graphene nanosheets and cerium nanoparticles (G/CeO2 ) was applied to the extraction of Se(IV), As(V), As(III), Cu(II) and Pb(II). The structure of G/CeO2 was investigated by scanning electron microscopy, X-ray diffraction and Raman spectroscopy. The optimal pH values for extraction are 4.0 for As(V), 3.0 for Se(IV), and 6.0 for both Cu(II) and Pb(II). The maximum adsorption capacity of G/CeO2 (expressed as mg·g-1 ) were calculated by the Langmuir model and are found to be 8.4 for As(V), 14...
April 23, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29685594/safety-tolerability-and-immunogenicity-of-intramuscular-administration-of-prp-crm-197-hib-vaccine-to-healthy-japanese-children-an-open-label-trial
#12
Takehiro Togashi, Nodoka Mitsuya, Shuji Sumino, Yohei Takanami
BACKGROUND: Japan licensed the conjugate Haemophilus influenzae type b vaccine, Vaxem™ Hib, based on clinical studies using subcutaneous injection. The present study was performed to ensure this vaccine is suitable for intramuscular injection in Japanese children. METHODS: Thirty-one healthy 2-6-month-old infants received three doses of Vaxem™ Hib by intramuscular injection at 4-week intervals and a booster dose 1 year later, concomitant with routine infant (DTaP-IPV and pneumococcal) and toddler (measles-rubella) vaccines...
April 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29680811/does-the-age-of-acute-care-physicians-impact-their-1-crisis-management-performance-and-2-learning-after-simulation-based-education-a-protocol-for-a-multicentre-prospective-cohort-study-in-toronto-and-ottawa-canada
#13
Fahad Alam, Vicki R LeBlanc, Alan Baxter, Jordan Tarshis, Dominique Piquette, Yuqi Gu, Caroline Filipkowska, Ashley Krywenky, Nicole Kester-Greene, Pierre Cardinal, Shelly Au, Sandy Lam, Sylvain Boet, Perioperative Anesthesia Clinical Trials Group
INTRODUCTION: The proportion of older acute care physicians (ACPs) has been steadily increasing. Ageing is associated with physiological changes and prospective research investigating how such age-related physiological changes affect clinical performance, including crisis resource management (CRM) skills, is lacking. There is a gap in the literature on whether physician's age influences baseline CRM performance and also learning from simulation. We aim to investigate whether ageing is associated with baseline CRM skills of ACPs (emergency, critical care and anaesthesia) using simulated crisis scenarios and to assess whether ageing influences learning from simulation-based education...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29676343/histopathological-report-of-colorectal-carcinoma-resections-a-5-year-audit-in-lagos
#14
Kabir Bolarinwa Badmos, Olorunda Rotimi, Abdulrazzaq Oluwagbemiga Lawal, Adedapo O Osinowo, Mohammed Y Habeebu, Fatimah Biade Abdulkareem
Background: Complete and accurate pathology reporting of colorectal carcinoma (CRC) resection specimen is critical to clinical management of individual patients. The study aims to audit colorectal cancer histopathology reporting in Lagos between 2011 and 2015 before the adoption of the Society for Gastroenterology and Hepatology in Nigeria pro forma in 2016. Materials and Methods: All resected CRC cases were identified from the Histopathology record of our Department and that of a private Laboratory in Lagos over a 5-year from 2011 to 2015...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29668252/multielement-determination-of-trace-heavy-metals-in-water-by-microwave-induced-plasma-atomic-emission-spectrometry-after-extraction-in-unconventional-single-salt-aqueous-biphasic-system
#15
Svetlana Smirnova, Tatiana Samarina, Dmitry Ilin, Igor V Pletnev
For the first time liquid-liquid extraction was used for the preconcentration of heavy metals prior to their determination in water by microwave-induced plasma atomic emission spectrometry (MP-AES). Extraction of Pb(II), Cd(II), Co(II), Ni(II), Zn(II), and Cu(II) was performed in unconventional aqueous biphasic system (ABS) formed by addition of hydrophobic solid salt, namely, tetrahexylammonium bromide, to aqueous sample, with neither organic solvents nor salting-out agents being used. The metal ions were quantitatively recovered with 4-(2-pyridylazo)-resorcinol (PAR)...
April 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29661774/accuracy-safety-and-reliability-of-novel-phase-i-trial-designs
#16
Heng Zhou, Ying Yuan, Lei Nie
A number of novel model-based and model-assisted designs have been proposed to find the maximum tolerated dose (MTD) in phase I clinical trials, but their differences and relative pros and cons are not clear to many practitioners. We review three model-based designs, including the continual reassessment method (CRM), dose escalation with overdose control (EWOC), and Bayesian logistic regression model (BLRM), and three model-assisted designs, including the modified toxicity probability interval (mTPI), Bayesian optimal interval (BOIN), and keyboard designs...
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29660666/on-line-supercritical-fluid-extraction-supercritical-fluid-chromatography-mass-spectrometry-of-polycyclic-aromatic-hydrocarbons-in-soil
#17
A Paige Wicker, Doug D Carlton, Kenichiro Tanaka, Masayuki Nishimura, Vivian Chen, Tairo Ogura, William Hedgepeth, Kevin A Schug
On-line supercritical fluid extraction - supercritical fluid chromatography - mass spectrometry (SFE-SFC-MS) has been applied for the determination of polycyclic aromatic hydrocarbons (PAHs) in soil. The purpose of this study was to develop and validate the first on-line SFE-SFC-MS method for the quantification of PAHs in various types of soil. By coupling the sample extraction on-line with chromatography and detection, sample preparation is minimized, diminishing sample loss and contamination, and significantly decreasing the required extraction time...
April 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29650404/stereotactic-ablative-radiotherapy-after-concomitant-chemoradiotherapy-in-non-small-cell-lung-cancer-a-tite-crm-phase-1-trial
#18
Jérôme Doyen, Michel Poudenx, Jocelyn Gal, Josiane Otto, Caroline Guerder, Arash O Naghavi, Anais Gérard, Axel Leysalle, Charlotte Cohen, Bernard Padovani, Antoine Ianessi, Renaud Schiappa, Emmanuel Chamorey, Pierre-Yves Bondiau
BACKGROUND AND PURPOSE: Platinum based chemoradiotherapy is the standard of care for inoperable non-small cell lung cancer (NSCLC). With evidence that NSCLC can have a dose dependent response with stereotactic ablative radiotherapy (SABR), we hypothesize that a SABR boost on residual tumor treated with chemoradiotherapy could increase treatment efficacy. The purpose of this study was to determine feasibility of such an approach. MATERIAL AND METHODS: A prospective phase I trial was performed including 26 patients...
April 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29644605/a-new-marine-sediment-certified-reference-material-crm-for-the-determination-of-persistent-organic-contaminants-iaea-459
#19
Imma Tolosa, Roberto Cassi, David Huertas
A new marine sediment certified reference material (IAEA 459) with very low concentrations (μg kg-1 ) for a variety of persistent organic contaminants (POPs) listed by the Stockholm Convention, as well as other POPs and priority substances (PSs) listed in many environmental monitoring programs was developed by the IAEA. The sediment material was collected from the Ham River estuary in South Korea, and the assigned final values were derived from robust statistics on the results provided by selected laboratories which demonstrated technical and quality competence, following the guidance given in ISO Guide 35...
April 11, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29643222/-in-vivo-characterization-of-bivalve-larval-shells-a-confocal-raman-microscopy-study
#20
Kirti Ramesh, Frank Melzner, Andrew W Griffith, Christopher J Gobler, Caroline Rouger, Deniz Tasdemir, Gernot Nehrke
In vivo confocal Raman microscopy (CRM), polarized light microscopy and Fourier transform infrared spectroscopy (FTIR) were used to determine if a significant amount of amorphous calcium carbonate (ACC) exists within larval shells of Baltic mytilid mussels ( Mytilus edulis -like) and whether the amount of ACC varies during larval development. No evidence for ACC was found from the onset of shell deposition at 21 h post-fertilization (hpf) until 48 hpf. Larval Mytilus shells were crystalline from 21 hpf onwards and exhibited CRM and FTIR peaks characteristic of aragonite...
April 2018: Journal of the Royal Society, Interface
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