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https://www.readbyqxmd.com/read/28530566/in-situ-quantification-of-%C3%AE-carotene-partitioning-in-oil-in-water-emulsions-by-confocal-raman-microscopy
#1
W A Fahmi Wan Mohamad, Roman Buckow, MaryAnn Augustin, Don McNaughton
Confocal Raman microscopy (CRM) was able to quantify the β-carotene concentration in oil droplets and determine the partitioning characteristics of β-carotene within the emulsion system in situ. The results were validated by a conventional method involving solvent extraction of β-carotene separately from the total emulsion as well as the aqueous phase separated by centrifugation, and quantification by absorption spectrophotometry. CRM also enabled the localization of β-carotene in an emulsion. From the Raman image, the β-carotene partitioning between the aqueous and oil phases of palm olein-in-water emulsions stabilized by whey protein isolate (WPI) was observed...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28522139/in-vivo-confocal-raman-microscopic-determination-of-depth-profiles-of-the-stratum-corneum-lipid-organization-influenced-by-application-of-various-oils
#2
ChunSik Choe, Johannes Schleusener, Jürgen Lademann, Maxim E Darvin
BACKGROUND: The intercellular lipids (ICL) of stratum corneum (SC) play an important role in maintaining the skin barrier function. The lateral and lamellar packing order of ICL in SC is not homogenous, but rather depth-dependent. OBJECTIVE: This study aimed to analyze the influence of the topically applied mineral-derived (paraffin and petrolatum) and plant-derived (almond oil and jojoba oil) oils on the depth-dependent ICL profile ordering of the SC in vivo. METHOD: Confocal Raman microscopy (CRM), a unique tool to analyze the depth profile of the ICL structure non-invasively, is employed to investigate the interaction between oils and human SC in vivo...
May 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28514891/synergistic-effect-of-rapamycin-and-metformin-against-age-dependent-oxidative-stress-in-rat-erythrocyte
#3
Abhishek Kumar Singh, Geetika Garg, Sandeep Singh, Syed Ibrahim Rizvi
Erythrocytes are particularly vulnerable towards age-dependent oxidative stress mediated damage. Caloric restriction mimetics (CRMs) may provide a novel strategy for the maintenance of redox balance as well as effective treatment of age associated diseases. Herein, we have investigated the beneficial effect of co-treatment of CRM-candidate drugs, rapamycin (an immunosuppressant drug and inhibitor of mammalian target of rapamycin) and metformin (an anti-diabetic biguanide and activator of adenosine monophosphate kinase) against aging-induced oxidative stress in erythrocytes and plasma of aging rats...
May 17, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28513561/the-effect-of-physicochemical-modification-on-the-function-of-antibodies-induced-by-anti-nicotine-vaccine-in-mice
#4
Jennifer M Thorn, Keshab Bhattacharya, Renata Crutcher, Justin Sperry, Colleen Isele, Barbara Kelly, Libbey Yates, James Zobel, Ningli Zhang, Heather L Davis, Michael J McCluskie
Smoking remains one of the major causes of morbidity and mortality worldwide. One approach to assisting smoking cessation is via anti-nicotine vaccines, composed of nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). We have previously shown that the carrier, hapten, linker, hapten load, degree of conjugate aggregation, and presence of adducts can each influence the function (nicotine-binding capacity) of the antibody (Ab) induced. Herein, we extend those findings and show that tertiary structure is also critical to the induction of functional immune responses and that this can be influenced by conjugation conditions...
May 17, 2017: Vaccines
https://www.readbyqxmd.com/read/28503808/a-pilot-randomized-study-comparing-extralevator-with-conventional-abdominoperineal-excision-for-low-rectal-cancer-after-neoadjuvant-chemoradiation
#5
Ramakrishnan Ayloor Seshadri, Nicholas P West, Shirley Sundersingh
AIMS: The aims of this study were to assess the feasibility of performing an extralevator abdominoperineal excision (ELAPE) after neoadjuvant chemoradiation, to compare the rates of circumferential resection margin (CRM) involvement and intra-operative perforation (IOP) of the specimen, and to assess the amount of tissue removed around the muscularis propria (MP)/internal sphincter (IS) of the lower rectum in patients with low rectal cancer undergoing ELAPE as compared to conventional abdominoperineal excision (CAPE) after NCRT...
May 15, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28502421/is-neoadjuvant-chemoradiotherapy-always-necessary-for-mid-high-local-advanced-rectal-cancer-a-comparative-analysis-after-propensity-score-matching
#6
Y Zhang, Y Sun, Z Xu, P Chi, X Lu
AIM: This study was aimed to compare perioperative and oncological outcomes of mid/high locally advanced midrectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (NCRT) vs. surgery alone, and to identify risk factors for local recurrence in mid/high LARC. METHOD: A total of 471 mid/high LARC patients treated with surgery alone or NCRT (50.4 Gy in 28 fractions) with concurrent FOLFOX/XELOX followed by TME in 6-8 weeks from 2008 to 2014 were matched 1:1 by using propensity score analysis...
May 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28501208/evaluation-of-a-quechers-like-extraction-approach-for-the-determination-of-pbdes-in-mussels-by-immuno-assay-based-screening-methods
#7
Sara Romanelli, Francesca Bettazzi, Tania Martellini, Weilin L Shelver, Alessandra Cincinelli, Roberta Galarini, Ilaria Palchetti
A sample preparation method was evaluated for the determination of polybrominated diphenyl ethers (PBDEs) in mussel samples, by using colorimetric and electrochemical immunoassay-based screening methods. Herein, a rapid procedure based on QuEChERS-like extraction approach followed by solid phase purification was optimized for PBDE extraction from mussel samples. The detection limits for colorimetric and electrochemical immunoassays, calculated as BDE-47 equivalent concentration, were 0.6ngg(-1) and 1.1ngg(-1), respectively...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28501200/a-new-approach-to-calibration-and-determination-of-selected-trace-elements-in-food-contact-polymers-by-la-icp-ms
#8
Monica Voss, Matheus A G Nunes, Gabriela Corazza, Erico M M Flores, Edson I Müller, Valderi L Dressler
A calibration strategy using porous nylon disks and reference solutions is proposed for the first time for matrix matching and determination of As, Ba, Cd, Cr, Pb, Sr and Zn in polymers by laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS). Polymer samples commonly used in contact with food were analyzed. The procedure consists on the use of porous nylon disks as support for a dried droplet reference solution. Calibration in the range of 0.50-190μgg(-1) for Ba, Cd, Cr, Pb, Sr and Zn and from 0...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28497059/a-new-algorithm-for-identifying-cis-regulatory-modules-based-on-hidden-markov-model
#9
Haitao Guo, Hongwei Huo
The discovery of cis-regulatory modules (CRMs) is the key to understanding mechanisms of transcription regulation. Since CRMs have specific regulatory structures that are the basis for the regulation of gene expression, how to model the regulatory structure of CRMs has a considerable impact on the performance of CRM identification. The paper proposes a CRM discovery algorithm called ComSPS. ComSPS builds a regulatory structure model of CRMs based on HMM by exploring the rules of CRM transcriptional grammar that governs the internal motif site arrangement of CRMs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28487056/polysaccharide-conjugate-vaccine-protein-carriers-as-a-neglected-valency-potential-and-limitations
#10
REVIEW
Michael Bröker, Francesco Berti, Joerg Schneider, Ivo Vojtek
The development of vaccines against polysaccharide-encapsulated pathogens (e.g. Haemophilus influenzae type b, pneumococci, meningococci) is challenging because polysaccharides do not elicit a strong and long-lasting immune response (i.e. T-cell independent). This can be overcome by conjugating the polysaccharide to a protein carrier (e.g. tetanus toxoid, cross-reacting material 197 [CRM]), which vastly improves the immune response and induces memory to the polysaccharide (T-cell dependent). Although it is well documented that protein carriers additionally induce an immune response against themselves, this potential "additional valency" has so far not been recognized...
June 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28481748/lessons-from-crew-resource-management-for-cardiac-surgeons
#11
Patrick Marvil, Curt Tribble
Crew resource management (CRM) describes a system developed in the late 1970s in response to a series of deadly commercial aviation crashes. This system has been universally adopted in commercial and military aviation and is now an integral part of aviation culture. CRM is an error mitigation strategy developed to reduce human error in situations in which teams operate in complex, high-stakes environments. Over time, the principles of this system have been applied and utilized in other environments, particularly in medical areas dealing with high-stakes outcomes requiring optimal teamwork and communication...
April 30, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28481086/nontargeted-identification-of-reactive-metabolite-protein-adducts
#12
Michael G Leeming, William A Donald, Richard A J O'Hair
Metabolic bioactivation of many different chemicals results in the formation of highly reactive compounds (chemically reactive metabolites, CRMs) that can lead to toxicity via binding to macromolecular targets (e.g., proteins or DNA). There is a need to develop robust, rapid, and nontargeted analytical techniques to determine the identity of the protein targets of CRMs and their sites of modification. Here, we introduce a nontargeted methodology capable of determining both the identity of a CRM formed from an administered compound as well as the protein targets modified by the reactive metabolite in a single experiment without prior information...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28477432/laparoscopic-abdominoperineal-resection-with-trans-abdominal-individualized-levator-transection-interim-analysis-of-a-randomized-controlled-trial
#13
Bo Feng, Jiaoyang Lu, Sen Zhang, Xialin Yan, Jianwen Li, Pei Xue, Mingliang Wang, Aiguo Lu, Junjun Ma, Lu Zang, Feng Dong, Zirui He, Fei Yue, Jing Sun, Xizhou Hong, Minhua Zheng
AIM: Extralevator abdominoperineal resection) (ELAPR) is challenging "conventional" adbominoperineal resection (APR) yet the safety and efficacy of ELAPR is still under debate. We therefore developed a laparoscopic APR with transabdominal individualized levator transection (LAPR-TILT) approach and compared the outcome with a conventional laparoscopic APR (CLAPR). METHOD: All eligible patients were entered a single center randomized controlled trial to compare CLAPR and LAPR-TILT...
May 6, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28463042/defining-components-of-team-leadership-and-membership-in-prehospital-emergency-medical-services
#14
Remle P Crowe, Robert L Wagoner, Severo A Rodriguez, Melissa A Bentley, David Page
BACKGROUND: Teamwork is critical for patient and provider safety in high-stakes environments, including the setting of prehospital emergency medical services (EMS). OBJECTIVE: We sought to describe the components of team leadership and team membership on a single patient call where multiple EMS providers are present. METHODS: We conducted a two-day focus group with nine subject matter experts in crew resource management (CRM) and EMS using a structured nominal group technique (NGT)...
May 2, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28452901/effect-of-pain-and-analgesia-on-compensatory-reserve
#15
Carmen Hinojosa-Laborde, Jessie Renee D Fernandez, Gary W Muniz, Corinne D Nawn, Rebecca K Burns, Thuan H Le, Kathy B Porter, John T Hardy, Victor A Convertino
BACKGROUND: The measurement of the body's capacity to compensate for reduced blood volume can be assessed with a Compensatory Reserve Measurement (CRM). The CRM, which is calculated from changes in features of the arterial waveform, represents the integration of compensatory mechanisms during states of low tissue perfusion and oxygenation such as hemorrhage. This study was designed to test the hypothesis that pain which activates compensatory mechanisms and analgesia that result in reduced blood pressure are associated with lower compensatory reserve...
April 27, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28445849/a-reference-measurement-procedure-for-amino-acids-in-blood-using-isotope-dilution-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#16
Juok Kim, Thi Thanh Huong Tran, Seon-Pyo Hong, Ji-Seon Jeong
We described a reference measurement procedure for amino acid (AA) quantification in blood samples based on deproteinization with 5-sulfosalicylic acid (SSA) and an isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry (LC-MS) method. The serum was deproteinized with 15% v/v SSA and the supernatant was injected directly into the LC-MS system without further processing. Compared with the use of other precipitants and water as a control, five model AAs-valine, isoleucine, leucine, tyrosine, and phenylalanine-in the SSA-treated samples showed ionization enhancement as well as stable background signals without significant ion suppression effects...
April 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28441505/error-detection-based-model-to-assess-educational-outcomes-in-crisis-resource-management-training-a-pilot-study
#17
Sarah Bouhabel, Emily Kay-Rivest, Carol Nhan, Ilana Bank, Peter Nugus, Rachel Fisher, Lily Hp Nguyen
Otolaryngology-head and neck surgery (OTL-HNS) residents face a variety of difficult, high-stress situations, which may occur early in their training. Since these events occur infrequently, simulation-based learning has become an important part of residents' training and is already well established in fields such as anesthesia and emergency medicine. In the domain of OTL-HNS, it is gradually gaining in popularity. Crisis Resource Management (CRM), a program adapted from the aviation industry, aims to improve outcomes of crisis situations by attempting to mitigate human errors...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28436197/magnetic-resonance-imaging-following-neoadjuvant-chemoradiation-and-transanal-endoscopic-microsurgery-for-rectal-cancer
#18
Guilherme P São Julião, Cinthia Denise Ortega, Bruna Borba Vailati, Angelita Habr-Gama, Laura Melina Fernandez, Joaquim Gama-Rodrigues, Sergio Eduardo Araujo, Rodrigo O Perez
AIM: Full thickness local excision after neoadjuvant chemoradiotherapy (CRT) for patients with rectal cancer and incomplete clinical response has been a treatment strategy for organ preservation. Follow up of these patients is challenging since anatomic distortion and postoperative changes may be clinically indistinguishable from tumor recurrence. Magnetic resonance imaging (MRI) may have a role in detecting recurrence. The aim of this study is to describe the MRI findings during follow-up in patients having local excision following CRT with and without local recurrence...
April 24, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28429295/idiopathic-benign-paroxysmal-positional-vertigo-in-the-elderly-a-long-term-follow-up-study
#19
Seong-Chul Yeo, Seong-Ki Ahn, Ho Joong Lee, Hyun-Jin Cho, Sang-Wook Kim, Seung Hoon Woo, Sea-Yuong Jeon, Yeon-Hee Joo, Dong Gu Hur, Jung Je Park
BACKGROUND: Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral-type vertigo in the elderly. While some studies have investigated BPPV among the elderly, no study has focused on the isolated idiopathic BPPV (iBPPV) in the elderly. AIMS: To investigate the clinical features and recurrence rate in elderly patients diagnosed with iBPPV. METHODS: The authors prospectively reviewed the medical records of 627 patients diagnosed with BPPV, and a total of 370 patients fulfilled the inclusion criteria...
April 20, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28427628/ultrasonic-energy-enhanced-the-efficiency-of-advance-extraction-methodology-for-enrichment-of-trace-level-of-copper-in-serum-samples-of-patients-having-neurological-disorders
#20
Mariam S Arain, Tasneem G Kazi, Hassan I Afridi, Jamshed Ali, Asma Akhtar
An innovative dual dispersive ionic liquid based on ultrasound assisted microextraction (UDIL-μE), for the enrichment of trace levels of copper ion (Cu(2+)), in serum (blood) of patients suffering from different neurological disorders. The enriched metal ions were subjected to flame atomic absorption spectrometry (FAAS). In the UDIL-μE method, the extraction solvent, ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate [C4mim][PF6], was dispersed into the aqueous samples using an ultrasonic bath...
July 2017: Ultrasonics Sonochemistry
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