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https://www.readbyqxmd.com/read/29141700/can-a-customer-relationship-management-program-improve-recruitment-for-primary-care-research-studies
#1
Sharon Johnston, Sabrina T Wong, Stephanie Blackman, Leena W Chau, Anne M Grool, William Hogg
BACKGROUND: Recruiting family physicians into primary care research studies requires researchers to continually manage information coming in, going out, and coming in again. In many research groups, Microsoft Excel and Access are the usual data management tools, but they are very basic and do not support any automation, linking, or reminder systems to manage and integrate recruitment information and processes. OBJECTIVE: We explored whether a commercial customer relationship management (CRM) software program - designed for sales people in businesses to improve customer relations and communications - could be used to make the research recruitment system faster, more effective, and more efficient...
November 16, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29140414/dose-finding-designs-for-cumulative-toxicities-using-multiple-constraints
#2
Shing M Lee, Moreno Ursino, Ying Kuen Cheung, Sarah Zohar
This article addresses the concern regarding late-onset dose-limiting toxicities (DLT), moderate toxicities below the threshold of a DLT and cumulative toxicities that may lead to a DLT, which are mostly disregarded or handled in an ad hoc manner when determining the maximum tolerated dose (MTD) in dose-finding cancer clinical trials. An extension of the Time-to-Event Continual Reassessment Method (TITE-CRM) which allows for the specification of toxicity constraints on both DLT and moderate toxicities, and can account for partial information is proposed...
November 13, 2017: Biostatistics
https://www.readbyqxmd.com/read/29139541/characterization-of-the-autophagy-related-gene-8a-atg8a-promoter-in-drosophila-melanogaster
#3
Arundhati Bali, Bhupendra V Shravage
Autophagy is an evolutionarily conserved process which is upregulated under various stress conditions, including nutrient stress and oxidative stress. Amongst autophagy related genes (Atgs), Atg8a (LC3 in mammals) is induced several-fold during nutrient limitation in Drosophila. The minimal Atg8a cis-regulatory module (CRM) which mediates transcriptional upregulation under various stress conditions is not known. Here, we describe the generation and analyses of a series of Atg8a promoter deletions which drive the expression of an mCherry-Atg8a fusion cassette...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29136903/multivariate-optimization-of-a-procedure-employing-microwave-assisted-digestion-for-the-determination-of-nickel-and-vanadium-in-crude-oil-by-icp-oes
#4
Shirlei L Dos Anjos, Jeferson C Alves, Sarah A Rocha Soares, Rennan G O Araujo, Olivia M C de Oliveira, Antonio F S Queiroz, Sergio L C Ferreira
This work presents the optimization of a sample preparation procedure using microwave-assisted digestion for the determination of nickel and vanadium in crude oil employing inductively coupled plasma optical emission spectrometry (ICP OES). The optimization step was performed utilizing a two-level full factorial design involving the following factors: concentrated nitric acid and hydrogen peroxide volumes, and microwave-assisted digestion temperature. Nickel and vanadium concentrations were used as responses...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136867/deep-eutectic-solvent-based-advance-microextraction-method-for-determination-of-aluminum-in-water-and-food-samples-multivariate-study
#5
Abdul Haleem Panhwar, Mustafa Tuzen, Tasneem Gul Kazi
Preconcentration of aluminum Al(3+) was carried out by a novel deep eutectic solvent based ultrasound-assisted liquid phase microextraction (DES-UALPME) method. The deep eutectic solvents (DESs), a green solvent was first time used for enrichment and quantification of very low concentration of Al(3+) in water and food samples, prior to analysed by electrothermal atomic absorption spectrometry (ETAAS). In present method it was observed that % recovery of Al-8-hydroxyquinoline chelates efficiently extracted by DES solvent...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136454/immediate-label-free-ex-vivo-evaluation-of-human-brain-tumor-biopsies-with-confocal-reflectance-microscopy
#6
Jennifer M Eschbacher, Joseph F Georges, Evgenii Belykh, Mohammedhassan Izady Yazdanabadi, Nikolay L Martirosyan, Emily Szeto, Catherine Y Seiler, Michael A Mooney, Jessica K Daniels, Katherine Y Goehring, Kendall R Van Keuren-Jensen, Mark C Preul, Stephen W Coons, Shwetal Mehta, Peter Nakaji
Confocal microscopy utilizing fluorescent dyes is widely gaining use in the clinical setting as a diagnostic tool. Reflectance confocal microscopy is a method of visualizing tissue specimens without fluorescent dyes while relying on the natural refractile properties of cellular and subcellular structures. We prospectively evaluated 76 CNS lesions with confocal reflectance microscopy (CRM) to determine cellularity, architecture, and morphological characteristics. A neuropathologist found that all cases showed similar histopathological features when compared to matched hematoxylin and eosin-stained sections...
December 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29122553/fisetin-as-a-caloric-restriction-mimetic-protects-rat-brain-against-aging-induced-oxidative-stress-apoptosis-and-neurodegeneration
#7
Sandeep Singh, Abhishek Kumar Singh, Geetika Garg, Syed Ibrahim Rizvi
AIM: In the present study, attempts have been made to evaluate the potential role of fisetin, a caloric restriction mimetic (CRM), for neuroprotection in D-galactose (D-gal) induced accelerated and natural aging models of rat. MAIN METHODS: Fisetin was supplemented (15mg/kg b.w., orally) to young, D-gal induced aged (D-gal 500mg/kg b.w subcutaneously) and naturally aged rats for 6weeks. Standard protocols were employed to measure pro-oxidants, antioxidants and mitochondrial membrane potential in brain tissues...
November 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/29120515/the-effects-of-crew-resource-management-on-teamwork-and-safety-climate-at-veterans-health-administration-facilities
#8
Miriam E Schwartz, Deborah E Welsh, Douglas E Paull, Regina S Knowles, Lori D DeLeeuw, Robin R Hemphill, Keith E Essen, Gary L Sculli
Communication failure is a significant source of adverse events in health care and a leading root cause of sentinel events reported to the Joint Commission. The Veterans Health Administration National Center for Patient Safety established Clinical Team Training (CTT) as a comprehensive program to enhance patient safety and to improve communication and teamwork among health care professionals. CTT is based on techniques used in aviation's Crew Resource Management (CRM) training. The aviation industry has reached a significant safety record in large part related to the culture change generated by CRM and sustained by its recurrent implementation...
November 9, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29101570/transanal-total-mesorectal-excision-pathological-results-of-186-patients-with-mid-and-low-rectal-cancer
#9
F Borja de Lacy, Jacqueline J E M van Laarhoven, Romina Pena, María Clara Arroyave, Raquel Bravo, Miriam Cuatrecasas, Antonio M Lacy
BACKGROUND: Transanal total mesorectal excision (TaTME) seems to be a valid alternative to the open or laparoscopic TME. Quality of the TME specimen is the most important prognostic factor in rectal cancer. This study shows the pathological results of the largest single-institution series published on TaTME in patients with mid and low rectal cancer. METHODS: We conducted a retrospective cohort study of all consecutive patients with rectal cancer, treated by TaTME between November 2011 and June 2016...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29100742/outcome-of-neoadjuvant-chemoradiation-in-mri-staged-locally-advanced-rectal-cancer-retrospective-analysis-of-123-chinese-patients
#10
Shing Fung Lee, Chi Leung Chiang, Francis Ann Shing Lee, Yiu Wah Wong, Chi Ming Poon, Frank Chi Sing Wong, Stewart Yuk Tung
BACKGROUND: For advanced rectal cancer with involved or threatened mesorectal fascia (MRF), current standard is pre-operative long course chemoradiotherapy (PLCRT) with either capecitabine or 5-fluorouracil (5-FU). However, few Chinese data on its clinical outcome are available, especially for those with pelvic MRI staging. METHODS: Between Jan-2009 and Oct-2014, 123 consecutive patients with biopsy proven adenocarcinoma of rectum, all with pelvic MRI staging, selected for PLCRT after multi-disciplinary team discussion were recruited...
November 1, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29100110/feedback-of-the-third-interlaboratory-exercise-organised-on-wheat-in-the-framework-of-the-obt-working-group
#11
N Baglan, C Cossonnet, E Roche, S B Kim, I Croudace, P Warwick
Organically bound tritium (OBT) has become of increasing interest within the last decade, with a focus on its behaviour and also its analysis, which are both important to assess tritium distribution in the environment and dose consequences. After the first OBT International Workshop which was held in France in May 2012, an international working group was created. The expected benefits are the following: remove or reduce uncertainty in OBT analysis results, provide better OBT model validation data and better public dose results, increase the number of potential measuring OBT laboratories, validate all of the stages of the procedures based on a larger population and more statistically significant results, and investigate the feasibility of CRM's and RM's production...
October 31, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29098536/performance-and-meat-quality-characteristics-of-broilers-fed-fermented-mixture-of-grated-cassava-roots-and-palm-kernel-cake-as-replacement-for-maize
#12
A K Chukwukaelo, N O Aladi, N J Okeudo, H O Obikaonu, I P Ogbuewu, I C Okoli
Performance and meat quality characteristics of broilers fed fermented mixture of grated cassava roots and palm kernel cake (FCP-mix) as a replacement for maize were studied. One hundred and eighty (180), 7-day-old broiler chickens were divided into six groups of 30 birds, and each group replicated thrice. Six experimental diets were formulated for both starter and finisher stages with diets 1 and 6 as controls. Diet 1 contained maize whereas diet 6 contained a 1:1 mixture of cassava root meal (CRM) and palm kernel cake (PKC)...
November 2, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29098433/effect-of-transanal-total-mesorectal-excision-for-rectal-cancer-comparison-of-short-term-outcomes-with-laparoscopic-and-open-surgeries
#13
Sharaf Karim Perdawood, Benjamin Sejr Thinggaard, Maya Xania Bjoern
OBJECTIVE: To compare short-term results of total mesorectal excision (TME) for mid and low rectal cancer, achieved by transanal (TaTME), laparoscopic (LaTME), and open (OpTME) approaches. BACKGROUND: The impact of TaTME on the surgical treatment of mid and low rectal cancer has yet to be clarified. METHODS: This is a case-matched study, based on data from a prospectively maintained database of patients who underwent TaTME from May 2015 to March 2017, and a retrospective chart review of patients who underwent LaTME and OpTME in the previous period...
November 2, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29095657/redispersible-spray-dried-lipid-core-nanocapsules-intended-for-oral-delivery-the-influence-of-the-particle-number-on-redispersibility
#14
Diego Fontana de Andrade, Branko Vukosavljevic, Edilson Valmir Benvenutti, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Maike Windbergs, Ruy Carlos Ruver Beck
This study proposes a new approach to produce easily redispersible spray-dried lipid-core nanocapsules (LNC) intended for oral administration, evaluating the influence of the particle number density of the fed sample. The proposed approach to develop redispersible spray-dried LNC formulations intended for oral route is innovative, evidencing the needing of an optimization of the initial particle number density in the liquid suspension of nanocapsules. A mixture of maltodextrin and L-leucine (90:10 w/w) was used as drying adjuvant...
November 2, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29084394/metastatic-malignancy-to-the-colon-and-rectum-a-report-of-14-cases-from-one-single-institute
#15
Chi-Chun Lin, Chun-Chi Lin, Wei-Shone Chen, Tzu-Chen Lin, Jen-Kou Lin, Jeng-Kai Jiang
BACKGROUND: Metastatic malignancy occurs rarely in the colon or rectum. We presented 14 patients with colorectal metastasis (CRM). METHODS: A retrospective review was conducted on a computerized colorectal tumor database at the Taipei Veterans General Hospital from January 2000 to June 2013. RESULTS: The incidence of CRM was 0.19% (14 in 7,524 patients). There were 6 males and 8 females with a mean age of 66.9 ± 13.6 years. Origins of the CRM included lung cancers (n = 3), prostate cancers (n = 2), and others (n = 1, respectively)...
October 31, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29083461/development-of-a-virtual-crew-resource-management-training-program-to-improve-communication
#16
Dana Tschannen
Crew Resource Management (CRM), a method focused on the management of human error and risk reduction, has shown promise in reducing communication failure in health care. The purpose of this project was to develop a virtual training program in CRM principles of effective leadership and followership, and evaluate the applicability to nurses working in the hospital setting. The intervention included the development of a virtual CRM training program consisting of a self-learning module and virtual simulation. Beta testing of the module was conducted by six nurses, followed by an evaluation of the training program by nurses (n = 5) in a general medicine department...
November 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/29072610/spectrum-effect-relationships-between-fingerprints-of-caulophyllum-robustum-maxim-and-inhabited-pro-inflammation-cytokine-effects
#17
Shaowa Lü, Shuyu Dong, Dan Xu, Jixin Duan, Guoyu Li, Yuyan Guo, Haixue Kuang, Qiuhong Wang
Caulophyllum robustum Maxim (CRM) is a Chinese folk medicine with significant effect on treatment of rheumatoid arthritis (RA). This study was designed to explore the spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and the anti-inflammatory effects of CRM. Seventeen common peaks were detected by fingerprint similarity evaluation software. Among them, 15 peaks were identified by Liquid Chromatography-Mass Spectrometry (LC-MS). Pharmacodynamics experiments were conducted in collagen-induced arthritis (CIA) mice to obtain the anti-inflammatory effects of different batches of CRM with four pro-inflammation cytokines (TNF-α, IL-β, IL-6, and IL-17) as indicators...
October 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29068989/outcomes-of-patients-with-abdominoperineal-resection-apr-and-low-anterior-resection-lar-who-had-very-low-rectal-cancer
#18
Seung-Seop Yeom, In Ja Park, Sung Woo Jung, Se Heon Oh, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Nayoung Kim, Chang Sik Yu, Jin Cheon Kim
We compared the oncological outcomes of sphincter-saving resection (SSR) and abdominoperineal resection (APR) in 409 consecutive patients with very low rectal cancer (i.e., tumors within 3 cm from the anal verge); 335 (81.9%) patients underwent APR and 74 (18.1%) underwent SSR. The APR group comprised higher proportions of men (67.5% vs 55.4%, P = .049) and advanced-stage patients (P < .001). Preoperative chemoradiotherapy (PCRT) was more frequently administered in the SSR group (83.8% vs 52.8%, P < ...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29067578/transanal-versus-abdominal-low-rectal-dissection-for-rectal-cancer-long-term-results-of-the-bordeaux-randomized-trial
#19
Quentin Denost, Paula Loughlin, Remy Chevalier, Bertrand Celerier, Romain Didailler, Eric Rullier
AIM: The aim of the current study is to report long-term outcomes after transanal low rectal dissection compared with the conventional laparoscopic approach within the context of the Bordeaux' randomized trial. Results from this randomized trial have indicated that transanal approach was more effective than laparoscopic dissection regarding the rate of negative circumferential resection margin (CRM). Despite a high number of publications regarding the transanal approach for TME, there were no long-term data on survival and local recurrence which are now required...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29067426/effect-of-robotic-assisted-vs-conventional-laparoscopic-surgery-on-risk-of-conversion-to-open-laparotomy-among-patients-undergoing-resection-for-rectal-cancer-the-rolarr-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
David Jayne, Alessio Pigazzi, Helen Marshall, Julie Croft, Neil Corrigan, Joanne Copeland, Phil Quirke, Nick West, Tero Rautio, Niels Thomassen, Henry Tilney, Mark Gudgeon, Paolo Pietro Bianchi, Richard Edlin, Claire Hulme, Julia Brown
Importance: Robotic rectal cancer surgery is gaining popularity, but limited data are available regarding safety and efficacy. Objective: To compare robotic-assisted vs conventional laparoscopic surgery for risk of conversion to open laparotomy among patients undergoing resection for rectal cancer. Design, Setting, and Participants: Randomized clinical trial comparing robotic-assisted vs conventional laparoscopic surgery among 471 patients with rectal adenocarcinoma suitable for curative resection conducted at 29 sites across 10 countries, including 40 surgeons...
October 24, 2017: JAMA: the Journal of the American Medical Association
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