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https://www.readbyqxmd.com/read/28105657/a-nomogram-to-predict-distant-metastasis-after-neoadjuvant-chemoradiotherapy-and-radical-surgery-in-patients-with-locally-advanced-rectal-cancer
#1
Yanwu Sun, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Xiaojie Wang, Pan Chi
PURPOSE: To compare distant metastasis (DM) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery alone, and to develop a predictive nomogram for DM following nCRT. METHODS: Propensity-scoring match analysis was performed to compare DM in LARC treated with nCRT (n = 375) and surgery alone (n = 375). Cox regression was performed to identify predictors of DM following nCRT. A nomogram was developed and validated by internal (n = 425) and external validation (n = 97)...
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28105170/expression-of-chromosomal-regional-maintenance-protein-1-may-be-associated-with-subcellular-survivin-expression-in-human-gastric-and-colorectal-carcinoma
#2
Michiko Shintani, Akito Tashiro, Akiko Sangawa, Naoki Yamao, Shingo Kamoshida
Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and subcellular localization of CRM-1 in human gastric and colorectal carcinomas and to assess the association between CRM-1 and survivin expression in these tumor types. The nuclear and cytoplasmic CRM-1 expression rates in gastric carcinoma were 61% (42/69) and 29% (20/69), respectively, while the nuclear and cytoplasmic CRM-1 expression rates in colorectal carcinoma were 55% (43/78) and 37% (29/78), respectively...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28099870/single-embryo-resolution-quantitative-analysis-of-reporters-permits-multiplex-spatial-cis-regulatory-analysis
#3
Catherine L Guay, Sean T McQuade, Jongmin Nam
Cis-regulatory modules (CRMs) control spatiotemporal gene expression patterns in embryos. While measurement of quantitative CRM activities has become efficient, measurement of spatial CRM activities still relies on slow, one-by-one methods. To overcome this bottleneck, we have developed a high-throughput method that can simultaneously measure quantitative and spatial CRM activities. The new method builds profiles of quantitative CRM activities measured at single-embryo resolution in many mosaic embryos and uses these profiles as a 'fingerprint' of spatial patterns...
January 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28094415/outcome-of-nonunion-fractures-in-dogs-treated-with-fixation-compression-resistant-matrix-and-recombinant-human-bone-morphogenetic-protein-2
#4
Anna M Massie, Amy S Kapatkin, Mark C Fuller, Frank J M Verstraete, Boaz Arzi
OBJECTIVES: To report the use of compression resistant matrix (CRM) infused with recombinant human bone morphogenetic protein (rhBMP-2) prospectively in the healing of nonunion long-bone fractures in dogs. METHODS: A longitudinal cohort of dogs that were presented with nonunion fractures were classified and treated with CRM soaked with rhBMP-2 and fracture fixation. They were followed with serial radiographs and evaluated for healing times and complications according to the time frame and definitions previously established for orthopaedic clinical cases...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28087370/laparoscopic-versus-open-surgery-for-rectal-cancer-a-meta-analysis-of-classic-randomized-controlled-trials-and-high-quality-nonrandomized-studies-in-the-last-5-years
#5
REVIEW
Ke Chen, Guodong Cao, Bo Chen, Mingqing Wang, Xingyu Xu, Wenwen Cai, Yicheng Xu, Maoming Xiong
OBJECTIVE: To present a meta-analysis of high-quality published reports comparing laparoscopic rectal resection (LRR) and open rectal resection (ORR) for rectal cancer. METHODS: Studies that compared LRR and ORR and were published within the last 5 years were identified. All eligible randomized controlled trials (RCTs) and non-randomized comparative trials (NRCTs) were evaluated based on the Jadad score, the Cochrane risk of bias assessment tool and modified Methodological Indices for Nonrandomized Studies (MINORS)...
January 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28043865/investigation-of-the-cutaneous-penetration-behavior-of-dexamethasone-loaded-to-nano-sized-lipid-particles-by-epr-spectroscopy-and-confocal-raman-and-laser-scanning-microscopy
#6
Silke B Lohan, Siavash Saeidpour, Agnieszka Solik, Sabine Schanzer, Heike Richter, Pin Dong, Maxim E Darvin, Roland Bodmeier, Alexa Patzelt, Gaith Zoubari, Michael Unbehauen, Rainer Haag, Jürgen Lademann, Christian Teutloff, Robert Bittl, Martina C Meinke
An improvement of the penetration efficiency combined with the controlled release of actives in the skin can facilitate the medical treatment of skin diseases immensely. Dexamethasone (Dx), a synthetic glucocorticoid, is frequently used for the treatment of inflammatory skin diseases. To investigate the penetration of nano-sized lipid particles (NLP) loaded with Dx in comparison to a commercially available base cream, different techniques were applied. Electron paramagnetic resonance (EPR) spectroscopy was used to monitor the penetration of Dx, which was covalently labeled with the spin probe 3-(Carboxy)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (PCA)...
December 30, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28040561/development-and-characterization-of-anti-inflammatory-activity-of-curcumin-loaded-biodegradable-microspheres-with-potential-use-in-intestinal-inflammatory-disorders
#7
E Blanco-García, F J Otero-Espinar, J Blanco-Méndez, J M Leiro-Vidal, A Luzardo-Álvarez
This research addresses the development and in vitro evaluation of a microparticulate system intended for intestine-targeted delivery of curcumin (CRM), a natural polyphenol with anti-inflammatory properties. Microspheres (Ms) based on zein (ZN) and Gantrez(®) AN119 (PVMMA) were prepared by spray-drying and coated with a pH-sensitive polymer (Eudragit(®) FS30D). An experimental design was performed to optimize the microparticulate formulation. A detailed characterization of systems was carried out by SEM, DSC, FTIR, particle size, ζ potential measurements and in vitro CRM release...
December 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28038460/the-comprehensive-therapeutic-effects-of-rectal-surgery-are-better-in-laparoscopy-a-systematic-review-and-meta-analysis
#8
Jiabin Zheng, Xingyu Feng, Zifeng Yang, Weixian Hu, Yuwen Luo, Yong Li
BACKGROUND: Laparoscopic-assisted radical resection of rectal cancer was reported as advantageous compared to laparotomy resection. However, this finding remains controversial, especially given the two recent randomized controlled trials published on The Journal of the American Medical Association (JAMA). OBJECTIVE: To perform a meta-analysis that compares the short-term and long-term outcomes of laparoscopic and open surgery for rectal cancer. DATA SOURCE: To identify clinical trials comparing laparoscopic and open surgery for rectal cancer published by August 2016, we searched the PubMed, Cochrane Library, Springer Link and Clinicaltrials...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035252/signet-ring-colorectal-carcinoma-do-we-need-to-improve-the-treatment-algorithm
#9
Anup Sunil Tamhankar, Parag Ingle, Reena Engineer, Munita Bal, Vikas Ostwal, Avanish Saklani
AIM: To elaborate about this peculiar variant from a tertiary cancer center from India. METHODS: It's a retrospective study (2011-2014) of all patients diagnosed with signet ring colo-rectal cancer (SRCC). Various clinico-pathological variables were studied. RESULTS: One hundred and seventy consecutive patients with SRCC were diagnosed (11.4% of all colorectal cancers). Median Age of the cohort was 41 years. Most common location was recto-sigmoid area (54...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28029540/use-of-a-booster-dose-of-capsular-group-c-meningococcal-glycoconjugate-vaccine-to-demonstrate-immunologic-memory-in-children-primed-with-one-or-two-vaccine-doses-in-infancy
#10
David Pace, Ameneh Khatami, Simon Attard-Montalto, Merryn Voysey, Adam Finn, Saul N Faust, Paul T Heath, Ray Borrow, Matthew D Snape, Andrew J Pollard
BACKGROUND: Use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group C meningococcal conjugate vaccines (MenCC) risks induction of immunologic hyporesponsiveness. For this reason, MenCC vaccines are now used as probes of immunologic memory, however, no studies have demonstrated their ability to distinguish primed from unprimed children. METHODS: This study was part of a randomised controlled trial investigating the immunogenicity of a booster dose of the combined Haemophilus influenzae type b and MenC-tetanus toxoid vaccine (Hib-MenC-TT) in infants receiving reduced dose MenCC vaccine priming schedules (one MenC-CRM/MenC-TT or two MenC-CRM vaccine doses) compared with an unprimed group...
October 28, 2016: Vaccine
https://www.readbyqxmd.com/read/28028288/a-cost-effectiveness-analysis-of-self-debriefing-versus-instructor-debriefing-for-simulated-crises-in-perioperative-medicine-in-canada
#11
Wanrudee Isaranuwatchai, Fahad Alam, Jeffrey Hoch, Sylvain Boet
PURPOSE: High-fidelity simulation training is effective for learning crisis resource management (CRM) skills, but cost is a major barrier to implementing high-fidelity simulation training into the curriculum. The aim of this study was to examine the cost-effectiveness of self-debriefing and traditional instructor debriefing in CRM training programs and to calculate the minimum willingness-to-pay (WTP) value when one debriefing type becomes more cost-effective than the other. METHODS: This study used previous data from a randomized controlled trial involving 50 anesthesiology residents in Canada...
2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28025240/safety-of-quadrivalent-meningococcal-conjugate-vaccine-in-11-to-21-year-olds
#12
Hung-Fu Tseng, Lina S Sy, Bradley K Ackerson, Rulin C Hechter, Sara Y Tartof, Mendel Haag, Jeffrey M Slezak, Yi Luo, Christine A Fischetti, Harp S Takhar, Yan Miao, Marianne Cunnington, Zendi Solano, Steven J Jacobsen
BACKGROUND: Meningococcal conjugate vaccination is recommended in the United States. This study evaluates the safety of quadrivalent meningococcal conjugate vaccine in a cohort aged 11 to 21 years. METHODS: This cohort study with self-controlled case-series analysis was conducted at Kaiser Permanente Southern California. Individuals receiving MenACWY-CRM, a quadrivalent meningococcal conjugate vaccine, during September 30, 2011 to June 30, 2013, were included. Twenty-six prespecified events of interest (EOIs), including neurologic, rheumatologic, hematologic, endocrine, renal, pediatric, and pediatric infectious disease EOIs, were identified through electronic health records 1 year after vaccination...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/28019065/pregnancy-outcomes-in-women-with-mechanical-prosthetic-heart-valves-a-prospective-descriptive-population-based-study-using-the-united-kingdom-obstetric-surveillance-system-ukoss-data-collection-system
#13
S Vause, B Clarke, C L Tower, Crm Hay, M Knight
OBJECTIVE: To describe the incidence of mechanical prosthetic heart valves (MPHV) in pregnancy in the UK; rates of maternal and fetal complications in this group of women, and whether these vary with the anticoagulation used during pregnancy. DESIGN: Prospective descriptive population-based study. SETTING: All consultant-led maternity units in the UK. POPULATION: All women with an MPHV who were pregnant between 1 February 2013 and 31 January 2015...
December 26, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27997470/oncological-outcomes-after-robotic-proctectomy-for-rectal-cancer-analysis-of-a-prospective-database
#14
Tarik Sammour, Songphol Malakorn, Brian K Bednarski, Harmeet Kaur, Ui Sup Shin, Craig Messick, Yi-Qian Nancy You, George J Chang
OBJECTIVE: The aim of this study is to evaluate the oncological outcomes of robotic total mesorectal excision (TME) at an NCI designated cancer center. SUMMARY BACKGROUND DATA: The effectiveness of laparoscopic TME could not be established, but the robotic-assisted approach may hold some promise, with improved visualization and ergonomics for pelvic dissection. Oncological outcome data is presently lacking. METHODS: Patients who underwent total mesorectal excision or tumor-specific mesorectal excision for rectal cancer between April 2009 and April 2016 via a robotic approach were identified from a prospective single-institution database...
December 16, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27993416/phase-i-study-of-stereotactic-body-radiation-therapy-for-peripheral-t2n0m0-non-small-cell-lung-cancer-jcog0702-results-for-the-group-with-ptv%C3%A2-100cc
#15
Rikiya Onimaru, Hiroshi Onishi, Taro Shibata, Masahiro Hiraoka, Satoshi Ishikura, Katsuyuki Karasawa, Yukinori Matsuo, Masaki Kokubo, Yoshiyuki Shioyama, Haruo Matsushita, Yoshinori Ito, Hiroki Shirato
PURPOSE: A dose escalation study to determine the recommended dose (RD) with stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinomas (NSCLC) was conducted. The results of the group with PTV⩾100cc are reported in this paper. MATERIALS AND METHODS: The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the maximum tolerated dose (MTD). Dose limiting toxicity (DLT) was Grade 3 or higher radiation pneumonitis (RP), and Grade 2 or higher RP was used as a surrogate DLT...
December 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27979757/congenital-retinal-macrovessel-associated-with-vitreous-hemorrhage
#16
Neha Goel, Vinod Kumar, Basudeb Ghosh
A "congenital retinal macrovessel" (CRM) is an aberrant retinal vessel (frequently a vein) that traverses the central macula and supplies or drains both above and below the horizontal raphe. It is an uncommon entity that is usually disclosed on routine examination and may rarely cause a compromised visual acuity. We describe the case of an adolescent girl who underwent vitrectomy for vitreous hemorrhage and was found to have a CRM with vascular abnormalities. To our knowledge, this is the first report of vitreous hemorrhage secondary to a CRM...
December 12, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27979727/effects-of-heat-pretreatment-of-starch-on-graft-copolymerization-reaction-and-performance-of-resulting-starch-based-wood-adhesive
#17
Xianyu Zheng, Li Cheng, Zhengbiao Gu, Yan Hong, Zhaofeng Li, Caiming Li
In this study, effects of starch heat pretreatment at 70, 80 and 90°C on graft copolymerization reaction with vinyl acetate (VAc) and the performance of the resulting starch-based wood adhesive (SWA) were investigated. It was shown that SWA pretreated at 90°C achieved the best performance. At this temperature, the bonding capacity improved by 17.84% compared to the adhesive synthesized without heat pretreatment and the viscosity increased by 18.16% after 7 free-thaw cycles, much better than other samples...
December 12, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27973777/synthetic-core-promoters-as-universal-parts-for-fine-tuning-expression-in-different-yeast-species
#18
Rui M C Portela, Thomas Vogl, Claudia Kniely, Jasmin E Fischer, Rui Oliveira, Anton Glieder
Synthetic biology and metabolic engineering experiments frequently require the fine-tuning of gene expression to balance and optimize protein levels of regulators or metabolic enzymes. A key concept of synthetic biology is the development of modular parts that can be used in different contexts. Here, we have applied a computational multifactor design approach to generate de novo synthetic core promoters and 5' untranslated regions (UTRs) for yeast cells. In contrast to upstream cis-regulatory modules (CRMs), core promoters are typically not subject to specific regulation, making them ideal engineering targets for gene expression fine-tuning...
December 14, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27941239/the-influence-of-circumferential-resection-margins-on-survival-following-rectal-cancer-surgery
#19
Emil Mois, Florin Graur, Nadim Al Hajjar, Cosmin Puia, Adrian Cote, Florin Zaharie, Adrian Bartos, Noemi Al Momani, Flaviu Pop, Horatiu Neagos, George Ciorogar, Cornel Iancu
BACKGROUND AND AIMS: A negative (R0) circumferential resection margin (CRM) is described as one of the most important factor that decrease the rate of local recurrence in rectal cancer. The primary outcome of the study was the status of the CRM, while the secondary outcomes were local recurrence and overall survival. METHODS: Study includes 192 patients with rectal cancer operated between January 2012 and December 2013 in our Institute. The incidence of positive CRM and its impact on the survival rates after oncologic surgical resection were investigated along with factors that determine positive CRM...
December 20, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27918383/etiology-of-acute-otitis-media-in-children-less-than-5-years-of-age-a-pooled-analysis-of-10-similarly-designed-observational-studies
#20
Melissa K Van Dyke, Jean-Yves Pirçon, Robert Cohen, Shabir A Madhi, Andrés Rosenblüt, Mercedes Macias Parra, Khalid Al-Mazrou, Gerhard Grevers, Pio Lopez, Laura Naranjo, Felix Pumarola, Nuntigar Sonsuwan, William P Hausdorff
BACKGROUND: Acute otitis media (AOM) is an important cause of childhood morbidity and antibiotic prescriptions. However, the relative importance of the well-known otopathogens, Streptococcus pneumoniae (Spn) and Haemophilus influenzae (Hflu), remains unclear due to a limited number of tympanocentesis-based studies that vary significantly in populations sampled, case definitions, and heptavalent pneumococcal conjugate vaccine (PCV7-CRM) use. METHODS: We conducted a pooled analysis of results from ten AOM etiology studies of similar design the protocols of which were derived from a common protocol and conducted in children 3 months to 5 years of age in different countries...
November 30, 2016: Pediatric Infectious Disease Journal
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