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https://www.readbyqxmd.com/read/29050459/third-party-regulatory-t-cells-prevent-murine-acute-graft-versus-host-disease
#1
Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used in these models, third-party-derived Treg cells are a promising alternative for cell-based immunotherapy, as they can be screened for pathogens and cell activity, and banked for GVHD prevention...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29050430/extraction-and-physicochemical-characterization-of-broiler-gallus-gallus-domesticus-skin-gelatin-compared-to-commercial-bovine-gelatin
#2
E Aykin-Dinçer, A Koç, M Erbas
Gelatin was extracted from broiler (Gallus gallus domesticus) skins and analyzed to compare its physicochemical properties with those of commercial bovine gelatin. The average yield of broiler skin gelatin was 6.5% on a wet weight basis. Broiler skin gelatin had more α1-and α2-chains than β-chain and contained high molecular weight (γ-chain) polymers. Glycine was the dominant amino acid in broiler skin gelatin (20.26%), followed by proline (Pro) (15.12%) then hydroxyproline (Hyp) (11.36%). Compared to commercial bovine gelatin, broiler skin gelatin had less total imino acids (Pro and Hyp) but a higher (33...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050427/brazil-nut-meal-and-spray-dried-egg-powders-as-alternatives-to-synthetic-methionine-in-organic-laying-hen-diets
#3
H K Burley, P H Patterson
The United States organic poultry industry is currently facing a limitation on dietary inclusion of synthetic methionine (Met). This study investigated Brazil nut protein powder (BNPP), spray-dried egg white (SDEW), and spray-dried egg blend (70:30 albumen: yolk) (SDEB) as alternatives to synthetic Met in organic laying hen diets. A total of 270 Hy-Line Brown laying hens was fed 5 diets from 22 to 38 wk of age, with 6 replicates of 3 adjacent cages per diet and 3 hens per cage. Diets included a commercial control (COM) (non-organic with standard CP and synthetic Met), an organic control (ORG) (with no synthetic Met, but higher CP to meet Met requirements), and 3 organic treatment diets with no synthetic Met, but including BNPP, SDEW, or SDEB at levels to meet Met requirements...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050413/laying-hens-in-aviaries-with-different-litter-substrates-behavior-across-the-flock-cycle-and-feather-lipid-content
#4
D L M Campbell, A B A Ali, D M Karcher, J M Siegford
The tiered aviary for laying hens includes a floor litter area to promote foraging and dust bathing. Data are needed on hens' use of different litter substrates and effectiveness of substrates in removing excess feather lipids to ensure a suitable litter area. Bovans White hens were housed in commercial-style aviaries with access to one of 3 litter substrates (wood shavings, straw, or plastic turf mats-AstroTurf®, n = 4 aviary pens per substrate, 144 cage-reared hens populated per pen). Litter areas were videoed across 2 d each at 4 ages: immediately following first aviary opening (25 wk), then at 28, 50, and 68 weeks...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050407/layer-chicken-embryo-survival-to-hatch-when-administered-an-in-ovo-vaccination-of-strain-f-mycoplasma-gallisepticum-and-locations-of-bacteria-prevalence-in-the-newly-hatched-chick
#5
K E C Elliott, S L Branton, J D Evans, P D Gerard, E D Peebles
Mycoplasma gallisepticum (MG) is a bacterial pathogen that causes production losses in layer chickens. To combat MG, multiage layer facilities vaccinate pullets by either spray or eye-drop vaccination. The objective in this study was to evaluate the use of in ovo vaccination as a potential alternative for MG vaccination. Layer embryos at 18 d of incubation were either not-injected (control), or were hand-injected with either commercial Marek's disease vaccine diluent alone or with a high, medium, low, or very low dosage of a live attenuated strain F (FMG) vaccine suspended in the commercial diluent...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050366/the-resistance-mechanisms-and-treatment-strategies-for-egfr-mutant-advanced-non-small-cell-lung-cancer
#6
REVIEW
Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) have been established as the standard therapy for EGFR-sensitizing mutant advanced non-small-cell lung cancer (NSCLC). However, patients ultimately develop resistance to these drugs. There are several mechanisms of both primary and secondary resistance to EGFR-TKIs. The primary resistance mechanisms include point mutations in exon 18, deletions or insertions in exon 19, insertions, duplications and point mutations in exon 20 and point mutation in exon 21 of EGFR gene...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050061/-perioperative-anaphylaxia-on-drugs
#7
Wolfgang Pfützner, Hinnerk Wulf
The diagnostic evaluation of perioperative anaphylaxia is of great importance for the medical care of the affected persons in the context of renewed interventions in general anesthesia. The most frequent triggers include muscle relaxants, antibiotics, latex and analgesics of the type of the cyclooxygenase inhibitors, but other perioperatively administered drugs such as opioids, anesthetics, benzodiazepines, dyes, disinfectants and even corticosteroids or drug additives may also be the cause in rare cases. The most important aim is therefore the identification of the responsible drug, for which a near-time allergological diagnosis should be carried out within the first 4 weeks to 6 months after the reaction...
October 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29050033/expert-panel-statement-on-laparoscopic-living-donor-hepatectomy
#8
Ho-Seong Han, Jai Young Cho, Hironori Kaneko, Go Wakabayashi, Hideaki Okajima, Shinji Uemoto, Olivier Soubrane, Chee-Chien Yong, Chao-Long Chen, Tan To Cheung, Giulio Belli, Shoji Kubo, Yao-Ming Wu, Kuo-Hsin Chen, Roberto I Troisi, Choon Hyuck David Kwon, Kyung-Suk Suh, Arvinder S Soin, Ki-Hun Kim, Daniel Cherqui
BACKGROUND: With improvements in living donor liver transplantation (LDLT) techniques and the increased experience of surgeons in laparoscopic major liver resection, laparoscopic donor hepatectomy is performed increasingly. Therefore, expert opinion on this procedure is required. OBJECTIVE: The study aimed to report the current status and summarize the expert opinion on laparoscopic donor hepatectomy. METHODS: An expert consensus meeting was held on September 8, 2016, in Seoul, Korea...
October 20, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29050028/management-of-cavitated-root-caries-lesions-minimum-intervention-and-alternatives
#9
Michael F Burrow, Margaret A Stacey
The prevalence of root caries among the elderly is increasing. The lesion shape can vary considerably from a broad shallow saucer-shape to a deeper defined cavity. The variety of shapes poses a series of complications when considering restorative management. This is accompanied with a paucity of clinical evidence on treatment techniques and clinical outcomes. The current philosophy centered on conservative management of root caries will most likely provide patients with the greatest chance of maintaining their teeth...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29050026/new-preventive-approaches-part-i-functional-peptides-and-other-therapies-to-prevent-tooth-demineralization
#10
Marília Afonso Rabelo Buzalaf, Juliano Pelim Pessan
The limited effect of fluoride on root caries has prompted the study of new preventive therapies, which involve recently developed functional peptides, lasers, phosphate-based technologies, among several other approaches. Most of the specific peptides currently investigated have been developed based on the available information related to the protective action of salivary proteins, including statherin-derived peptides. Other peptides include 8DSS, self-assembling peptide P11-4, antimicrobial peptides, and casein phosphopeptides combined with amorphous calcium phosphate...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29049974/photolysis-study-of-octyl-p-methoxycinnamate-loaded-microemulsion-by-molecular-fluorescence-and-chemometric-approach
#11
Danielle Silva Nascimento, Matías Insausti, Beatriz Susana Fernández Band, Marcos Grünhut
Octyl p-methoxycinnamate (OMC) is one of the most widely used sunscreen agents. However, the efficiency of OMC as UV filter over time is affected due to the formation of the cis-isomer which presents a markedly lower extinction coefficient (εcis=12,600L mol(-1)cm(-1) at 291nm) than the original trans-isomer (εtrans=24,000L mol(-1)cm(-1) at 310nm). In this work, a novel carrier for OMC based on an oil-in-water microemulsion is proposed in order to improve the photostability of this sunscreen. The formulation was composed of 29...
October 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29049973/semi-analytical-representation-of-the-activation-level-in-stress-fibre-directions-as-alternative-to-the-angular-representation-in-the-bio-chemo-mechanical-model-for-cell-contractility
#12
Christian Rüdiger Bahls, Duy Truong, Ursula van Rienen
The bio-chemo-mechanical model has many applications in modelling cell contractility. In simulations this model usually is coupled to the continuum mechanics of the cell by defining a large number of directions for stress fibres at each point. In this paper, another representation for coupling the biochemical processes in the bio-chemo-mechanical model is introduced. Using a quadratic form to represent the angular dependency of the activation level, the model's number of degrees of freedom is significantly reduced...
October 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29049962/evaluation-of-methods-for-managing-censored-results-when-calculating-the-geometric-mean
#13
Hannah G Mikkonen, Bradley O Clarke, Raghava Dasika, Christian J Wallis, Suzie M Reichman
Currently, there are conflicting views on the best statistical methods for managing censored environmental data. The method commonly applied by environmental science researchers and professionals is to substitute half the limit of reporting for derivation of summary statistics. This approach has been criticised by some researchers, raising questions around the interpretation of historical scientific data. This study evaluated four complete soil datasets, at three levels of simulated censorship, to test the accuracy of a range of censored data management methods for calculation of the geometric mean...
October 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/29049944/bioaccumulation-and-effects-of-novel-chlorinated-polyfluorinated-ether-sulfonate-in-freshwater-alga-scenedesmus-obliquus
#14
Wei Liu, Jingwen Li, Lichen Gao, Zhou Zhang, Jing Zhao, Xin He, Xin Zhang
Chlorinated polyfluorinated ether sulfonate (Cl-PFESA) is a novel alternative compound for perfluorooctane sulfonate (PFOS), with its environmental risk not well known. The bioaccumulation and toxic effects of Cl-PFESA in the freshwater alga is crucial for the understanding of its potential hazards to the aquatic environment. Scenedesmus obliquus was exposed to Cl-PFESA at ng L(-1) to mg L(-1), with the exposure regime beginning at the environmentally relevant level. The total log BAF of Cl-PFESA in S. obliquus was 4...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049912/globular-chitosan-treatment-of-bovine-jugular-veins-evidence-of-anticalcification-efficacy-in-the-subcutaneous-rat-model
#15
Anna A Krasilnikova, David S Sergeevichev, Vladislav V Fomenko, Alexander A Korobeynikov, Maria B Vasilyeva, Alexander S Yunoshev, Alexander M Karaskov, Evgeny A Pokushalov
Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate due to its versatility, natural origin, and biocompatibility. We investigated the anticalcification efficacy of globular chitosan ("Chitozol") as it demonstrated the improved rate of water solubility as compared with conventional linear macromolecules of chitosan...
September 14, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29049878/unifying-exchange-sensitivity-in-transition-metal-spin-state-ordering-and-catalysis-through-bond-valence-metrics
#16
Terry Z H Gani, Heather J Kulik
Accurate predictions of spin-state ordering, reaction energetics and barrier heights are critical for the computational discovery of open-shell transition metal (TM) catalysts. Semilocal approximations in density functional theory, such as the generalized gradient approximation (GGA), suffer from delocalization error that causes them to overstabilize strongly bonded states. Descriptions of energetics and bonding are often improved by introducing a fraction of exact exchange (e.g., erroneous low-spin GGA ground states instead correctly predicted as high-spin with a hybrid functional)...
October 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29049870/dendrimers-breaking-the-paradigm-of-current-musculoskeletal-autoimmune-therapies
#17
REVIEW
Daniel B Rodrigues, Joaquim M Oliveira, Tírcia C Santos, Rui L Reis
The advances achieved by cell-based therapies to treat autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS), despite promising, are still insufficient for the current demands. RA and MS therapeutic approaches follow world guidelines to use disease modifying drugs and biological agents which, regardless of some good results in clinical outcomes, are well known for several systemic secondary side effects. Dendrimers are custom-made nanoparticles with proved clinical potential, displaying proper size, chemistries, immunomodulatory and anti-inflammatory properties...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29049856/is-left-upper-lobectomy-always-worthwhile-for-early-stage-lung-cancer-a-comparison-between-left-upper-lobectomy-trisegmentectomy-and-lingulectomy
#18
Vittorio Aprile, Pietro Bertoglio, Paolo Dini, Gerardo Palmiero, Alfredo Mussi, Marcello Carlo Ambrogi, Marco Lucchi
BACKGROUND AND OBJECTIVES: Lobectomy is the gold standard treatment for resectable Non-Small Cell Lung Cancer (NSCLC). We compared oncological outcomes of patients undergoing a "multi-segmentectomy" (trisegmentectomy or lingulectomy) and left upper lobectomy for early stage (T1-2, N0) NSCLC of the left upper lobe. METHODS: We retrospectively analyzed all patients with pathological early stage (T1-T2 N0) NSCLC located in left upper lobe who underwent a lobectomy, a trisegmentectomy, or a lingulectomy between 2006 and 2013, focusing on surgical and oncological outcomes...
October 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29049819/treatment-of-a-degenerated-sutureless-sorin-perceval%C3%A2-valve-using-an-edwards-sapien-3
#19
Norman Mangner, David Holzhey, Martin Misfeld, Axel Linke
Valve-in-valve implantation is an alternative to reoperation for patients with degenerated bioprostheses. This case report presents a 75-year-old woman presenting with worsening dyspnoea according New York Heart Association (NYHA) Class III after she had received a Sorin Perceval® S sutureless valve due to severe aortic valve stenosis 5 years ago. Echocardiography revealed a degenerated Perceval valve with severe valvular aortic regurgitation and stenosis. After exclusion of acute infective endocarditis, an Edwards SAPIEN 3 was implanted leading to an immediate haemodynamic improvement...
October 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049810/the-use-of-ultrasound-in-the-management-of-a-life-threatening-malignant-laryngotracheal-obstruction
#20
Alfonso Fiorelli, Gaetana Messina, Antonio Raucci, Mario Santini
Ultrasound is becoming a valuable diagnostic tool in the armamentarium of thoracic surgeons. We report its use to follow stent placement in the laryngotracheal position for management of life-threatening neoplastic obstruction. For this purpose, a 15-MHz linear probe was placed in the midline at the level of the cricoid cartilage. Ultrasound performed daily at bedside showed normal movement of vocal folds and no stent dislocation. This strategy may be an alternative to computed tomography scan or endoscopy to follow stent placement in extrathoracic airways...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
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