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https://www.readbyqxmd.com/read/29909581/switch-maintenance-therapy-with-docetaxel-and-bevacizumab-after-induction-therapy-with-cisplatin-pemetrexed-and-bevacizumab-in-advanced-non-squamous-non-small-cell-lung-cancer-a-phase-ii-study
#1
Koji Nishimoto, Masato Karayama, Naoki Inui, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Nao Inami, Shun Matsuura, Yusuke Kaida, Takashi Matsui, Kazuhiro Asada, Hiroyuki Matsuda, Masato Fujii, Mikio Toyoshima, Shiro Imokawa, Takafumi Suda
Switch maintenance therapy, using alternative agents that were not administered during induction chemotherapy, is a treatment option for advanced non-squamous non-small cell lung cancer (NSCLC). Bevacizumab is known to increase the efficacy of other chemotherapeutic agents; however, switch maintenance therapy with docetaxel and bevacizumab has not been adequately studied. The goal of this study was to evaluate the efficacy and safety of switch maintenance therapy with docetaxel and bevacizumab following induction therapy with cisplatin, pemetrexed, and bevacizumab...
June 16, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29909522/why-don-t-segregated-roma-do-more-for-their-health-an-explanatory-framework-from-an-ethnographic-study-in-slovakia
#2
Andrej Belak, Andrea Madarasova Geckova, Jitse P van Dijk, Sijmen A Reijneveld
OBJECTIVES: The health status of segregated Roma is poor. To understand why segregated Roma engage in health-endangering practices, we explored their nonadherence to clinical and public health recommendations. METHODS: We examined one segregated Roma settlement of 260 inhabitants in Slovakia. To obtain qualitative data on local-level mechanisms supporting Roma nonadherence, we combined ethnography and systematic interviewing over 10 years. We then performed a qualitative content analysis based on sociological and public health theories...
June 16, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29909512/the-effectiveness-of-endoscopic-gastroplasty-for-obesity-treatment-according-to-fda-thresholds-systematic-review-and-meta-analysis-based-on-randomized-controlled-trials
#3
REVIEW
Antonio Coutinho Madruga-Neto, Wanderley Marques Bernardo, Diogo Turiani Hourneaux de Moura, Vitor Ottoboni Brunaldi, Rafael Krieger Martins, Iatagan Rocha Josino, Eduardo Turiani Hourneaux de Moura, Thiago Ferreira de Souza, Marco Aurélio Santo, Eduardo Guimarães Hourneaux de Moura
Endoscopic bariatric therapies (EBTs) are promising alternatives to conventional surgery for obesity. The aim of this study is to compare efficacy and safety through a systematic review and meta-analysis of the endoscopic gastroplasty techniques versus conservative treatment. We searched MEDLINE, EMBASE, Cochrane CENTRAL, Lilacs/Bireme. Randomized controlled trials (RCTs) enrolling obese patients comparing endoscopic gastroplasty to sham or diet/exercise were considered eligible. Among 6014 records, three RCTs were selected for meta-analysis...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29909465/anteromedial-femoral-neck-plate-with-cannulated-screws-for-the-treatment-of-irreducible-displaced-femoral-neck-fracture-in-young-patients-a-preliminary-study
#4
Linbo Zhuang, Lisheng Wang, Dongming Xu, Zhiyong Wang
BACKGROUNDS: Although most displaced femoral neck fractures of young patients can be repositioned successfully by closed reduction, there are still some can not repositioned successfully by this way and open reductions are required. This type of fracture was defined as irreducible displaced femoral neck fracture in this study. The purpose of this study was to introduce a new technique using anteromedial femoral neck plate with cannulated screws fixation by open reduction for the treatment of irreducible displaced femoral neck fractures in young patients...
June 16, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29909458/what-about-the-herb-a-new-metabolomics-approach-for-synthetic-cannabinoid-drug-testing
#5
Lubertus Bijlsma, Rubén Gil-Solsona, Félix Hernández, Juan Vicente Sancho
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, creates a scenario with constantly moving analytical targets, making their monitoring and identification challenging. The development of fast screening strategies for SCs, not directly focused on their chemical structure, as an alternative to the commonly applied target acquisition methods, would be highly appreciated in forensic and public health laboratories...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29909433/pharmacokinetics-of-fentanyl-sublingual-spray-in-opioid-na%C3%A3-ve-participants-results-of-a-phase-1-multiple-ascending-dose-study
#6
Richard L Rauck, D Alexander Oh, Neil Singla, Christian Koch, Neha Parikh, Srinivas Nalamachu, Jin Yu, Steven James
BACKGROUND AND OBJECTIVES: Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may include those who have limited prior exposure to opioids, this phase 1, open-label, randomized, multiple ascending-dose study was conducted to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple doses of fentanyl sublingual spray in opioid-naïve participants. This article primarily reports the pharmacokinetics results...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909432/pharmacokinetics-of-a-novel-sildenafil-orodispersible-film-administered-by-the-supralingual-and-the-sublingual-route-to-healthy-men
#7
Luca Loprete, Chiara Leuratti, Valeria Frangione, Milko Radicioni
BACKGROUND: Sildenafil was the first selective drug available on the market as oral therapy for erectile dysfunction (ED). A novel sildenafil orodispersible film (ODF) for ED treatment, containing sildenafil citrate, has recently been marketed. OBJECTIVES: Study objective was to investigate sildenafil bioavailability of the novel ODF formulation after sublingual and supralingual administration. METHODS: In this randomised, two-way cross-over study, 12 healthy male volunteers received a single 50 mg sildenafil dose by the sublingual and supralingual administration routes...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909429/task-set-control-chunking-and-hierarchical-timing-in-rhythm-production
#8
Lars D Hestermann, Johan Wagemans, Ralf T Krampe
We investigated task-set control processes and chunking in 16 novices and 16 amateur musicians, who produced unimanual rhythms in three experimental conditions: low-level timing tasks required isochronous tapping at constant target durations; sequencing tasks consisted of individual rhythmic patterns comprising multiple target durations; the task-set control condition required alternations between two rhythmic patterns. According to our hierarchical timing control model conditions differed in their task-set control demands necessary to provide rhythm programs for the sequencing of individual intervals...
June 16, 2018: Psychological Research
https://www.readbyqxmd.com/read/29909425/binge-like-acquisition-of-%C3%AE-pyrrolidinopentiophenone-%C3%AE-pvp-self-administration-in-female-rats
#9
Mehrak Javadi-Paydar, Eric L Harvey, Yanabel Grant, Sophia A Vandewater, Kevin M Creehan, Jacques D Nguyen, Tobin J Dickerson, Michael A Taffe
RATIONALE: The synthetic cathinone α-pyrrolidinopentiophenone (α-PVP) has been associated with bizarre public behavior in users. Association of such behavior with extended binges of drug use motivates additional investigation, particularly since a prior study found that half of male rats experience a binge of exceptionally high intake, followed by sustained lower levels of self-administration during the acquisition of intravenous self-administration (IVSA) of a related drug, 3,4-methylenedioxypyrovalerone...
June 16, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29909405/long-story-short-an-introduction-to-the-short-term-and-long-term-six-sigma-quality-and-its-importance-in-the-laboratory-medicine-for-the-management-of-extra-analytical-processes
#10
Cristiano Ialongo, Sergio Bernardini
There is a compelling need for quality tools that enable effective control of the extra-analytical phase. In this regard, Six Sigma seems to offer a valid methodological and conceptual opportunity, and in recent times, the International Federation of Clinical Chemistry and Laboratory Medicine has adopted it for indicating the performance requirements for non-analytical laboratory processes. However, the Six Sigma implies a distinction between short-term and long-term quality that is based on the dynamics of the processes...
June 18, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29909400/effects-of-electroacupuncture-on-bladder-and-bowel-function-in-patients-with-transverse-myelitis-a-prospective-observational-study
#11
Jiani Wu, Yanjun Cheng, Zongshi Qin, Xiaoxu Liu, Zhishun Liu
OBJECTIVE: To preliminarily explore the effect of electroacupuncture (EA) on bladder and bowel dysfunction in patients with transverse myelitis. METHODS: Sixteen participants were treated with EA at bilateral BL32, BL33, and BL35 once a day, five times a week for the first 4 weeks, and once every other day, three times a week for the following 4 weeks. Patients were then followed up for 6 months. Bladder and bowel function, and the safety of EA, were assessed...
June 16, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29909366/identification-of-complement-inhibitory-activities-of-two-chemotherapeutic-agents-using-a-high-throughput-cell-imaging-based-screening-assay
#12
Lingjun Zhang, Yuriy Fedorov, Drew Adams, Feng Lin
Excessive complement activation contributes significantly to the pathogeneses of various diseases. Currently, significant developmental research efforts aim to identify complement inhibitors with therapeutic uses have led to the approval of one inhibitor for clinical use. However, most existing complement inhibitors are based on monoclonal antibodies, which have many drawbacks such as high costs and limited administration options. With this report, we establish an inexpensive, cell imaging-based high-throughput assay for the large-scale screening of potential small molecule complement inhibitors...
June 14, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29909335/selecting-sustainable-alternatives-for-cruise-ships-in-venice-using-multi-criteria-decision-analysis
#13
Marco Pesce, Stefano Terzi, Raid Issa Mahmoud Al-Jawasreh, Claudia Bommarito, Loris Calgaro, Stefano Fogarin, Elisabetta Russo, Antonio Marcomini, Igor Linkov
The rapid growth of cruise ship tourism increases the use of historic port cities as strategic hubs for cruise ship operators. Benefits derived from increased tourism for the municipality and cruise ships are often at odds with the environmental and social impacts associated with continued historical port use. This study illustrates the use of Multi-Criteria Decision Analysis (MCDA) for weighing of various criteria and metrics related to the environment, economy, and social sustainability for the selection of a sustainable cruise line route...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29909280/the-influence-of-articulation-dynamics-on-recognition-memory
#14
Berit Lindau, Sascha Topolinski
Previous research has demonstrated an effect of consonantal direction on preference, showing that words following inward articulation dynamics (e.g., EMOK or OPIK) are generally liked more than words following outward dynamics (e.g., EKOM or OKIP). The present studies extended this line of research by hypothesizing an effect of consonantal direction on recognition memory, specifically familiarity. In a total of 7 experimental studies (N = 1043), we tested and confirmed this hypothesis, consistently finding increased hits and false alarms for inward compared to outward pseudo-words...
June 14, 2018: Cognition
https://www.readbyqxmd.com/read/29909261/temporal-relationships-of-gh-igf-i-and-fructosamine-concentrations-in-pregnant-spanish-purebred-mares-a-substantial-contribution-from-the-hormonal-standpoint
#15
K Satué, M Marcilla, P Medica, C Cravana, E Fazio
Growth hormone (GH) and insulin-like growth factor (IGF-I) exert essential functions to maintain an adequate metabolic activity for correct placental and fetal development. Although fructosamine (FRUCT) is used in clinical evaluation to assess the glycaemic state, the relationships between GH, IGF-I and FRUCT remain unknown in the mare. Therefore, the objectives of this study were to evaluate the relationships among these parameters in pregnant mares. A total of 30 healthy Spanish Purebred mares, with an age range of 9...
May 30, 2018: Theriogenology
https://www.readbyqxmd.com/read/29909237/glycosylation-as-new-pharmacological-strategies-for-diseases-associated-with-excessive-angiogenesis
#16
REVIEW
Simon Bousseau, Luisa Vergori, Raffaella Soleti, Guy Lenaers, M Carmen Martinez, Ramaroson Andriantsitohaina
Angiogenesis is a complex process describing the growth of new blood vessels from existing vasculature, and is triggered by local pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which increase the metabolism of endothelial cells (ECs). Angiogenesis takes part in various physiological conditions such as embryogenesis, placental growth, and in pathological conditions such as tumor growth, diabetic retinopathy, rheumatoid arthritis (RA) and ischemic diseases. Current therapies against excessive angiogenesis target vascular growth signaling...
June 14, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#17
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29909212/flow-diversion-via-lvis-blue-within-an-enterprise-in-patients-with-vertebral-artery-dissecting-aneurysm
#18
Yong Cheol Lim, Yong Sam Shin, Joonho Chung
A new Low-profile Visualized Intraluminal Support device (LVIS Blue) is a braided stent that provides a higher degree of metal coverage. This stent may be beneficial for complete obliteration of an aneurysm due not only to its support of a higher occlusion rate using coils inside of the aneurysm but also to its flow diverting effect. We introduce and describe a new flow diversion technique using an LVIS Blue-within-an-Enterprise for patients with vertebral artery (VA) dissecting aneurysms. A 6-Fr guiding catheter was positioned in the ipsilateral VA...
June 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29909156/high-dose-influenza-vaccine-to-reduce-clinical-outcomes-in-high-risk-cardiovascular-patients-rationale-and-design-of-the-invested-trial
#19
Orly Vardeny, Jacob A Udell, Jacob Joseph, Michael E Farkouh, Adrian F Hernandez, Alison J McGeer, H Keipp Talbot, Deepak L Bhatt, Christopher P Cannon, Shaun G Goodman, Inder Anand, David L DeMets, Jon Temte, Janet Wittes, Kristin Nichol, Clyde W Yancy, J Michael Gaziano, Lawton S Cooper, KyungMann Kim, Scott D Solomon
BACKGROUND: Influenza leads to significant cardiopulmonary morbidity and mortality-particularly in patients with cardiovascular disease-that may be prevented with a standard influenza vaccine. However, patients with cardiovascular conditions have a reduced immune response to influenza vaccine, potentially resulting in reduced effectiveness for preventing clinical events. High-dose vaccine augments immune response in cardiac patients, suggesting that a high-dose influenza vaccination strategy may further reduce morbidity and mortality...
May 23, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909154/outcomes-of-relapsed-and-refractory-primary-mediastinal-thymic-large-b-cell-lymphoma-treated-with-second-line-therapy-and-intent-to-transplant
#20
Santosha Vardhana, Paul A Hamlin, Joanna Yang, Andrew Zelenetz, Craig S Sauter, Matthew J Matasar, Andy Ni, Joachim Yahalom, Craig H Moskowitz
Primary mediastinal (thymic) large B-cell lymphoma is a subtype of diffuse large B-cell lymphoma with distinct clinical, molecular and genetic features, many of which overlap with Hodgkin's lymphoma. Increasingly, initial therapy for these patients has employed dose-dense chemotherapy with or without radiation with excellent results. In patients with relapsed and primary refractory disease, outcomes of second-line therapy followed by consolidation with high-dose therapy and autologous stem cell transplantation remains largely undefined...
June 14, 2018: Biology of Blood and Marrow Transplantation
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