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https://www.readbyqxmd.com/read/29668138/-molecular-typing-of-leishmania-leishmania-amazonensis-and-species-of-the-subgenus-viannia-associated-with-cutaneous-and-mucosal-leishmaniasis-in-colombia-a-concordance-study
#1
Clemencia Ovalle-Bracho, Carolina Camargo, Yira Díaz-Toro, Marcela Parra-Muñoz
INTRODUCTION: Multilocus enzyme electrophoresis (MLEE) is the reference standard for the characterization of Leishmania species. The test is restricted to specialized laboratories due to its technical complexity, cost, and time required to obtain results. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is used to identify Leishmania species. OBJECTIVE: To establish the concordance between the two tests as identifying methods for circulating species in Colombia...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668072/a-unique-telomere-dna-expansion-phenotype-in-human-retinal-rod-photoreceptors-associated-with-aging-and-disease
#2
W Robert Bell, Alan K Meeker, Anthony Rizzo, Sumit Rajpara, Ian M Rosenthal, Miguel Flores Bellver, Silvia Aparicio Domingo, Xiufeng Zhong, John R Barber, Corinne E Joshu, M Valeria Canto-Soler, Charles G Eberhart, Christopher M Heaphy
We have identified a discrete, focal telomere DNA expansion phenotype in the photoreceptor cell layer of normal, non-neoplastic human retinas. This phenotype is similar to that observed in a subset of human cancers, including a large fraction of tumors of the central nervous system, which maintain their telomeres via the non-telomerase-mediated alternative lengthening of telomeres (ALT) mechanism. We observed that these large, ultra-bright telomere DNA foci are restricted to the rod photoreceptors and are not observed in other cell types...
April 18, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29668056/ii-the-proper-realms-of-medicines-and-their-alternatives-what-count-as-cures
#3
Kristi L Lockhart, Frank C Keil
No abstract text is available yet for this article.
June 2018: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/29668030/uv-c-irradiation-on-the-quality-of-green-tea-effect-on-catechins-antioxidant-activity-and-cytotoxicity
#4
Matthew J Vergne, Ankit Patras, Manreet S Bhullar, Lincoln M Shade, Michael Sasges, Kanyasiri Rakariyatham, Che Pan, Hang Xiao
Short-wavelength ultraviolet (UV-C) irradiation is a nonthermal processing technique that is a possible alternative to the heat-pasteurization of tea beverages. This study investigated the effect of UV-C irradiation on the polyphenolic and total phenolic contents of a green tea beverage and analyzed cytotoxicity of irradiated green tea using a novel continuous flow-through UV system. UV-C fluence levels ranging from 0 to 240 mJ/cm2 were delivered to green tea, and polyphenols were chemically profiled. Continuous-flow UV-C irradiation of the green tea beverage at a fluence of 68 mJ/cm2  induced a minor reduction in the concentration of the most abundant catechin in green tea, (-)-epigallocatechin gallate (EGCG), from 145 to 131...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29667935/one-step-synthesis-of-sno-hierarchical-architectures-under-room-temperature-and-their-photocatalytic-properties
#5
Wenxiu Liu, Lili Yin, Rui Zhang, Hailian Yang, Jing Ma, Wenbin Cao
3D hierarchical SnO architectures were synthesized via a one-step dissolution-precipitation route under room temperature using SnCl22H2O and Na2CO3 as initial reagents. The morphology and size of the prepared SnO structures could be easily tailored by alternating the solvent from deionized water with absolute ethanol. The SEM observation shows that the prepared 3D SnO hierarchical architectures were consisted of nanosheets. And the size of the SnO hierarchical architectures could be effectively reduced from 4 - 10 μm to 1 - 2 μm when the solvent was changed from water to ethanol while the thickness of the assembling nanosheets will be reduced from 200 - 500 nm to 20 - 30 nm at the same time...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667830/dynamics-of-contact-line-pinning-and-depinning-of-droplets-evaporating-on-micro-ribs
#6
Ali Mazloomi Moqaddam, Dominique Derome, Jan Carmeliet
The contact line dynamics of evaporating droplets deposited on a set of parallel micro-ribs is analyzed with the use of a recently developed entropic lattice Boltzmann model for two-phase flow. Upon deposition, part of the droplet penetrates into the space between ribs due to capillary action, while the remaining liquid of the droplet remains pinned on top of the micro-ribs. In a first stage, evaporation continues until the droplet undergoes a series of pinning-depinning events, showing alternatively constant contact radius and constant contact angle modes...
April 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29667777/induced-pluripotent-stem-cell-derived-conditional-medium-promotes-leydig-cell-anti-apoptosis-and-proliferation-via-autophagy-and-wnt-%C3%AE-catenin-pathway
#7
Xiaoling Guo, Yong Chen, Tingting Hong, Xianwu Chen, Yue Duan, Chao Li, Renshan Ge
Leydig cell transplantation is a better alternative in the treatment of androgen-deficient males. The main purpose of this study was to investigate the effects of induced pluripotent stem cell-derived conditioned medium (iPS-CM) on the anti-apoptosis, proliferation and function of immature Leydig cells (ILCs), and illuminate the underlying mechanisms. ILCs were exposed to 200 μmol/L hydrogen peroxide (H2 O2 ) for 24 hours with or without iPS-CM treatments. Cell apoptosis was detected by flow cytometric analysis...
April 18, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29667760/reactions-of-digallanes-with-p-and-d-block-lewis-bases-adducts-bis-gallyl-complexes-and-naked-ga-as-ligand
#8
Julia Schuster, Jonas Muessig, Rian D Dewhurst, Holger Braunschweig
A range of double carbene adducts of digallanes(4) are prepared from an existing double digallane adduct, and their halides are subsequently exchanged, establishing the feasibility of both base and halide exchange reactions from digallane adducts. Furthermore, a range of digallium species are treated with transition metal Lewis bases, leading alternatively to oxidative addition products, species with monocoordinate Ga+ ligands, and an unusual ditopic metal-only Lewis pair (MOLP). These results underline the manifold and unpredictable chemistry of halogallane species with Lewis bases...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29667710/towards-sustainable-c-h-functionalization-reactions-the-emerging-role-of-bio-based-reaction-media
#9
Stefano Santoro, Assunta Marrocchi, Daniela Lanari, Lutz Ackermann, Luigi Vaccaro
In the last decade, transition-metal catalyzed C-H functionalization reactions have progressed enourmosly, becoming a useful tool in organic synthesis and a practibable alternative to well-established methodologies. Very recently, research efforts have also been devoted to developing more sustainable C-H functionalization protocols, in order to increase their applicability. One of the most promising approaches in this sense is represented by the substitution of common reaction media with bio-based solvents...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29667683/nfsi-participated-intermolecular-aminoazidation-of-alkene-through-iron-catalysis
#10
Bowen Lei, Xiaojiao Wang, Lifang Ma, Yan Li, Ziyuan Li
An iron-catalysed intermolecular vicinal aminoazidation of alkenes, using N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl azide (TMSN3) as the imidating and azidating reagents, respectively, is described, which could potentially provide a valuable route toward diverse vicinal diamine derivatives of great significance in medicinal chemistry and organic synthesis. Such iron-catalysed aminative bisfunctionalization of alkenes with NFSI has not been reported yet. Comparing to previously employed copper or palladium catalysts, the iron catalyst, FeCl2, was demonstrated to be a good alternative for its comparable efficiency and broad alkene scope...
April 18, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29667668/synthesis-of-fused-pyrroles-containing-4-hydroxycoumarins-by-regioselective-metal-free-multicomponent-reactions
#11
Richa Mishra, Asim Jana, Anoop Kumar Panday, Lokman H Choudhury
The reaction of arylglyoxals, 4-hydroxycoumarin, and aromatic amines such as 7-amino-2-methylchromone, 6/7-aminoflavone, 7-amino-4-methylcoumarin, 1-amino-9-fluorenone, 1-aminoanthraquinone and aniline derivatives in acetic acid medium under microwave conditions provides the corresponding regioselective fused pyrroles having hydroxycoumarin and aryl substituents. Alternatively, we have developed another method using in situ arylglyoxals from acetophenone derivatives by I2/DMSO promoted C-H oxidation followed by one-pot three component cyclization reactions to provide similar fused pyrroles...
April 18, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29667561/comparative-in-vitro-efficacy-of-kefir-produced-from-camel-goat-ewe-and-cow-milk-on-haemonchus-contortus
#12
D Alimi, M Rekik, H Akkari
One of the great challenges of veterinary parasitology is the search for alternative methods for controlling gastrointestinal parasites in small ruminants. Milk kefir is a traditional source of probiotic, with great therapeutic potential. The objective of this study was to investigate the anthelmintic effects of kefir on the abomasal nematode Haemonchus contortus from sheep. The study used camel, goat, ewe and cow milk as a starting material, to produce camel, goat, cow and ewe milk kefir. All kefirs showed a significant concentration-dependent effect on H...
April 18, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29667560/can-the-tea-tree-oil-australian-native-plant-melaleuca-alternifolia-cheel-be-an-alternative-treatment-for-human-demodicosis-on-skin
#13
Nelson Siu Kei Lam, Xin Xin Long, Robert C Griffin, Mu-Kai Chen, James Cg Doery
Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Although current treatments other than TTO and T4O are relatively effective in controlling the demodex mite population and the related symptoms, more research on the efficacy and drug delivery technology is needed in order to assess its potential as an alternative treatment with minimal side-effect profile, low toxicity and low risk of demodex resistance...
April 18, 2018: Parasitology
https://www.readbyqxmd.com/read/29667531/is-tobacco-use-associated-with-neurocognitive-dysfunction-in-individuals-with-hiv
#14
Billy Tsima, Sarah Jane Ratcliffe, Robert Schnoll, Ian Frank, Dennis Larry Kolson, Robert Gross
INTRODUCTION: The prevalence of HIV-associated neurocognitive disorders continues to rise despite the widespread use of antiretroviral therapy. We aimed to define the risk of neurocognitive dysfunction among smokers relative to nonsmokers. METHODS: We conducted a retrospective cohort study including HIV-infected adults ages 21 to 65 years. The Mental Alternation Test (MAT) was the primary outcome. The odds of cognitive impairment were compared using random-effects logistic regression to adjust for potential confounders...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29667528/speech-and-language-therapists-views-about-aac-system-acceptance-by-people-with-acquired-communication-disorders
#15
Eliada Pampoulou
OBJECTIVE: Some adults with acquired communication disorders are faced with an inability to communicate coherently through verbal speech with their communication partners. Despite the fact that a variety of augmentative and alternative communication (AAC) aided systems is available to assist them in communicating, not all adults accept them. In Cyprus, there is scant research focusing on the factors that are linked to AAC system acceptance and abandonment. METHODS: To address this gap, this research involves exploring the experiences of six speech and language therapists supporting adults with acquired communication disorders, who could benefit from the use of AAC systems...
April 18, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29667516/comparison-on-surface-properties-and-desulfurization-of-mno-2-and-pyrolusite-blended-activated-carbon-by-steam-activation
#16
Guochen Zhang, Xin Zhao, Ping Ning, Danni Yang, Xia Jiang, Wenju Jiang
In this study, MnO2 and pyrolusite were used as the catalysts to prepare modified activated carbon, i.e., AC-Mn and AC-P, respectively, from coals by blending method and steam activation. The BET results indicated that the AC-P had higher surface areas and micropore volumes than the AC-Mn with the same blending ratio. The relative contents of basic functional groups (i.e. C = O, π-π*) on AC-P were slightly lower than those on AC-Mn, while both contained the same main metal species, i.e. MnO. The desulfurization results showed that with 3 wt% of blending ratio, AC-Mn3 and AC-P3 had higher sulfur capacities at 220 and 205 mg/g, respectively, which were much higher than blank one (149...
April 18, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29667512/alternative-technique-to-transfer-jaw-relations-for-custom-mandibular-advancement-devices-a-case-report
#17
Filiz Keyf, Defne Burduroğlu, Selma Fırat Güven, Bülent Çiftçi
Background Oral appliance therapy for obstructive sleep apnea can be helpful in mild and moderate cases. This clinical report evaluates the efficacy of a protocol that predicts an optimal jaw position and describes the response of a young OSA patient to treatment. Clinical Presentation A 27-year-old woman was diagnosed with moderate OSA and had an apnea-hypopnea index (AHI) of 25.8/hr. In order to fabricate a custom device, an alternative procedure to determine the optimal protrusion and vertical positioning of the jaw was applied...
April 18, 2018: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/29667493/non-adenomatous-pituitary-tumours-mimicking-functioning-pituitary-adenomas
#18
Zize Feng, Zhigang Mao, Zongming Wang, Bing Liao, Yonghong Zhu, Haijun Wang
OBJECTIVE: Pituicytomas and granular cell tumours (GCTs) of the neurohypophysis are considered non-adenomatous neoplasms in the sellar region. The association between hormone hypersecretion and the tumours is seldom discussed and unclear. Therefore, we attempt to investigate this association based on our experience and a review of the literature. METHODS: We report three patients who presented with Cushing's syndrome- or acromegaly-like symptoms at our institution...
April 18, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29667491/optimization-of-3d-print-material-for-the-recreation-of-patient-specific-temporal-bone-models
#19
Max Haffner, Austin Quinn, Tsung-Yen Hsieh, E Bradley Strong, Toby Steele
OBJECTIVE: Identify the 3D printed material that most accurately recreates the visual, tactile, and kinesthetic properties of human temporal bone Subjects and Methods: Fifteen study participants with an average of 3.6 years of postgraduate training and 56.5 temporal bone (TB) procedures participated. Each participant performed a mastoidectomy on human cadaveric TB and five 3D printed TBs of different materials. After drilling each unique material, participants completed surveys to assess each model's appearance and physical likeness on a Likert scale from 0 to 10 (0 = poorly representative, 10 = completely life-like)...
May 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29667471/cost-effectiveness-analysis-of-suvorexant-for-the-treatment-of-japanese-elderly-patients-with-chronic-insnomnia-in-a-virtual-cohort
#20
Shinichi Nishimura, Mutsuhiro Nakao
AIMS: We assessed the cost effectiveness of the orexin receptor antagonist suvorexant against zolpidem, the most widely used hypnotic benzodiazepine receptor agonist in Japan. To this end, a model was used that factored in insomnia and the risk for hip fractures, which have devastating effects on the elderly. METHODS: Data were derived from published papers. The target population was a virtual cohort of elderly patients (≥65 years) with insomnia residing in Japan...
April 18, 2018: Journal of Medical Economics
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