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https://www.readbyqxmd.com/read/28319182/the-viability-of-an-ecologically-valid-chronic-sleep-restriction-and-circadian-timing-protocol-an-examination-of-sample-attrition-compliance-and-effectiveness-at-impacting-sleepiness-and-mood
#1
David L Dickinson, Sean P A Drummond, Todd McElroy
Chronic sleep restriction (SR) increases sleepiness, negatively impacts mood, and impairs a variety of cognitive performance measures. The vast majority of work establishing these effects are tightly controlled in-lab experimental studies. Examining commonly-experienced levels of SR in naturalistic settings is more difficult and generally involves observational methods, rather than active manipulations of sleep. The same is true for analyzing behavioral and cognitive outcomes at circadian unfavorable times...
2017: PloS One
https://www.readbyqxmd.com/read/28314705/adolescents-daily-worry-morning-cortisol-and-health-symptoms
#2
Reout Arbel, Lauren Spies Shapiro, Adela C Timmons, Ilana Kellerman Moss, Gayla Margolin
PURPOSE: To assess short-term effects of daily worries on hypothalamic-pituitary-adrenal axis activity and later implications for adolescents' health symptoms. We hypothesized that heightened worry would be associated with stronger next-morning cortisol awakening response (CAR) to prepare the body for the demands of the upcoming day. Guided by biological adaptation to stress theories, we also hypothesized that dysregulated CAR would heighten associations between worries and later health symptoms, while also testing direct associations between worries and dysregulated CAR and health...
March 14, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28301050/addition-of-anti-leukotriene-agents-to-inhaled-corticosteroids-for-adults-and-adolescents-with-persistent-asthma
#3
REVIEW
Bhupendrasinh F Chauhan, Maya M Jeyaraman, Amrinder Singh Mann, Justin Lys, Ahmed M Abou-Setta, Ryan Zarychanski, Francine M Ducharme
BACKGROUND: Asthma management guidelines recommend low-dose inhaled corticosteroids (ICS) as first-line therapy for adults and adolescents with persistent asthma. The addition of anti-leukotriene agents to ICS offers a therapeutic option in cases of suboptimal control with daily ICS. OBJECTIVES: To assess the efficacy and safety of anti-leukotriene agents added to ICS compared with the same dose, an increased dose or a tapering dose of ICS (in both arms) for adults and adolescents 12 years of age and older with persistent asthma...
March 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28300651/sleep-fragmentation-hypersensitizes-healthy-young-women-to-deep-and-superficial-experimental-pain
#4
Stella Iacovides, Kezia George, Peter Kamerman, Fiona C Baker
The effect of sleep deprivation on pain sensitivity has typically been studied using total and partial sleep deprivation protocols. These protocols do not mimic the fragmented pattern of sleep disruption usually observed in individuals with clinical pain conditions. Therefore, we conducted a controlled-experiment to investigate the effect of sleep fragmentation on pain perception (deep pain: forearm muscle ischaemia, and superficial pain: graded pin-pricks applied to the skin) in 11 healthy young women following two consecutive nights of sleep fragmentation, compared with a normal night of sleep...
March 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28295581/pharmacokinetics-of-prolonged-release-tacrolimus-versus-immediate-release-tacrolimus-in-de-novo-liver-transplantation-a-randomized-phase-iii-sub-study
#5
Bo-Göran Ericzon, Evaristo Varo, Pavel Trunečka, Lutz Fischer, Michele Colledan, Bruno Gridelli, Andrés Valdivieso, John O'Grady, James Dickinson, Nasrullah Undre
BACKGROUND: With the same dose of tacrolimus, lower systemic exposure on the first day of dosing has been reported for prolonged-release tacrolimus compared with immediate-release tacrolimus, prompting investigation of differing initial doses. METHODS: This sub-study of a double-blind, randomized, phase III trial in de novo liver transplant recipients compared the pharmacokinetics of once-daily prolonged-release tacrolimus (initial dose: 0.2mg/kg/day) versus twice-daily immediate-release tacrolimus (initial dose: 0...
March 12, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28293474/transition-from-oxcarbazepine-to-eslicarbazepine-acetate-a-single-center-study
#6
Jussi Mäkinen, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: There is limited clinical evidence for comparison between oxcarbazepine (OXC) and eslicarbazepine acetate (ESL) in terms of tolerability, or how to execute the change from OXC to ESL. We report the process of transitioning patients with focal epilepsy from previous OXC treatment to ESL due to tolerability problems. The rationale for change from OXC is reported, and the outcome with respective to this rationale is analyzed in terms of tolerability and efficacy. MATERIALS AND METHODS: The subjects were transitioned overnight from OXC to ESL in a hospital inpatient setting...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28292254/impact-of-joint-involvement-on-patients-reported-outcomes-in-systemic-lupus-erythematosus
#7
Chiara Tani, Linda Carli, Andrea Delle Sedie, Lucrezia Riente, Sabrina Vagnani, Rosaria Talarico, Alessandra Della Rossa, Chiara Baldini, Stefano Bombardieri, Marta Mosca
OBJECTIVE: Joint involvement is common among patients with systemic lupus erythematosus (SLE). Aim of this work was to evaluate the correlation between the presence of joint involvement and patient-reported pain, perception of disease activity, general health and quality of life. METHODS: Fifty consecutive SLE patients were enrolled in the study. All patients underwent a complete clinical evaluation including a 44 joint count, in addition an ultrasound evaluation of joint involvement of hands and wrists was performed...
March 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28290065/does-stress-result-in-you-exercising-less-or-does-exercising-result-in-you-being-less-stressed-or-is-it-both-testing-the-bi-directional-stress-exercise-association-at-the-group-and-person-n-of-1-level
#8
Matthew M Burg, Joseph E Schwartz, Ian M Kronish, Keith M Diaz, Carmela Alcantara, Joan Duer-Hefele, Karina W Davidson
BACKGROUND: Psychosocial stress contributes to heart disease in part by adversely affecting maintenance of health behaviors, while exercise can reduce stress. Assessing the bi-directional relationship between stress and exercise has been limited by lack of real-time data and theoretical and statistical models. This lack may hinder efforts to promote exercise maintenance. PURPOSE: We test the bi-directional relationship between stress and exercise using real-time data for the average person and the variability-individual differences-in this relationship...
March 13, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28289873/patient-reported-outcomes-as-predictors-of-remission-in-early-rheumatoid-arthritis-patients-treated-with-tight-control-treat-to-target-approach
#9
Laura Kuusalo, Kari Puolakka, Hannu Kautiainen, Anna Karjalainen, Timo Malmi, Timo Yli-Kerttula, Marjatta Leirisalo-Repo, Vappu Rantalaiho
Identifying prognostic factors for remission in early rheumatoid arthritis (ERA) patients is of key clinical importance. We studied patient-reported outcomes (PROs) as predictors of remission in a clinical trial. We randomized 99 untreated ERA patients to receive remission-targeted treatment with three disease-modifying antirheumatic drugs and prednisolone for 24 months, and infliximab or placebo for the initial 6 months. At baseline, we measured following PROs: eight Short Form 36 questionnaire (SF-36) dimensions, patient's global assessment [PGA, visual analogue scale (VAS)], Health Assessment Questionnaire (HAQ), and pain VAS...
March 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28281375/undergraduate-medical-students-perceptions-of-their-learning-experience-in-pediatric-rotation-at-king-abdulaziz-university-medical-college-in-jeddah-saudi-arabia
#10
Nadia M Fida, Mohammed Farouq, Dhuha Alamawi, Hayat Kamfar
AIM: This study aimed to evaluate fifth-year medical students' perception of their learning experience during pediatric rotation at the medical college of King Abdulaziz University (KAU), Jeddah, Saudi Arabia. METHOD: This cross-sectional study was conducted by distributing a questionnaire to fifth-year students who attended the pediatric rotation at KAU, during 2013-2014. RESULTS: Three hundred fifty-six out of 360 students agreed to participate, representing a response rate of 99%...
March 10, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28280561/temporally-and-spatially-partitioned-behaviours-of-spinner-dolphins-implications-for-resilience-to-human-disturbance
#11
Julian A Tyne, David W Johnston, Fredrik Christiansen, Lars Bejder
Selective forces shape the evolution of wildlife behavioural strategies and influence the spatial and temporal partitioning of behavioural activities to maximize individual fitness. Globally, wildlife is increasingly exposed to human activities which may affect their behavioural activities. The ability of wildlife to compensate for the effects of human activities may have implications for their resilience to disturbance. Resilience theory suggests that behavioural systems which are constrained in their repertoires are less resilient to disturbance than flexible systems...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28277696/morning-self-efficacy-predicts-physical-activity-throughout-the-day-in-knee-osteoarthritis
#12
Ruixue Zhaoyang, Lynn M Martire, Martin J Sliwinski
OBJECTIVE: The purpose of this study was to examine the within-day and cross-day prospective effects of knee osteoarthritis (OA) patients' self-efficacy to engage in physical activity despite the pain on their subsequent physical activity assessed objectively in their natural environment. METHOD: Over 22 days, 135 older adults with knee OA reported their morning self-efficacy for being physically active throughout the day using a handheld computer and wore an accelerometer to measure moderate activity and steps...
March 9, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28277424/comparing-performance-during-morning-vs-afternoon-training-sessions-in-intercollegiate-basketball-players
#13
Aaron D Heishman, Michael A Curtis, Ethan Saliba, Robert J Hornett, Steven K Malin, Arthur L Weltman
Time of day is a key factor that influences the optimization of athletic performance. Intercollegiate coaches oftentimes hold early morning strength training sessions for a variety of factors including convenience. However, few studies have specifically investigated the effect of early morning vs. late afternoon strength training on performance indices of fatigue. This is athletically important because circadian/ultradian rhythms and alterations in sleep patterns can impact training ability. Therefore, the purpose of the present study was to examine the effects of morning vs...
March 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28274229/exposure-to-phthalates-and-bisphenol-a-are-associated-with-atopic-dermatitis-symptoms-in-children-a-time-series-analysis
#14
Eun-Hye Kim, Byoung-Hak Jeon, Jihyun Kim, Young-Min Kim, Youngshin Han, Kangmo Ahn, Hae-Kwan Cheong
BACKGROUND: Despite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children. METHODS: We surveyed 18 boys with AD (age 3-7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary...
March 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28272109/morning-blood-pressure-surge-is-associated-with-carotid-intima-media-thickness-in-prehypertensive-patients
#15
Sertac Alpaydin, Yasar Turan, Mustafa Caliskan, Zuhal Caliskan, Feyza Aksu, Serhan Ozyildirim, Zafer Buyukterzi, Osman Kostek, Haldun Muderrisoglu
OBJECTIVE: Morning blood pressure (BP) surge (MBPS) is defined as an excessive increase in the morning BP from the lowest systolic BP during sleep and is reported as a risk factor for cardiovascular events in current clinical studies. In this study, we aimed to investigate the relationship between MBPS and carotid intima-media thickness (C-IMT) in prehypertensive patients. PATIENTS AND METHODS: We evaluated the association between the rate of BP variation derived from ambulatory BP monitoring and C-IMT in patients with prehypertension...
March 7, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28271579/self-reported-sleep-quantity-quality-and-sleep-hygiene-in-elite-athletes
#16
Melanie Knufinke, Arne Nieuwenhuys, Sabine A E Geurts, Anton M L Coenen, Michiel A J Kompier
Sleep is essential for recovery and performance in elite athletes. While actigraphy-based studies revealed suboptimal sleep in athletes, information on their subjective experience of sleep is scarce. Relatively unexplored is also the extent to which athletes' sleep is adversely affected by environmental conditions and daytime behaviours, that is sleep hygiene. This study aimed to provide insight in sleep quantity, quality and its putative association with sleep hygiene. Participants were 98 elite (youth) athletes competing at the highest (inter-)national level...
March 8, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28268857/hrv4training-large-scale-longitudinal-training-load-analysis-in-unconstrained-free-living-settings-using-a-smartphone-application
#17
Marco Altini, Oliver Amft
We describe an approach to support athletes at various fitness levels in their training load analysis using heart rate (HR) and heart rate variability (HRV). A smartphone-based application (HRV4Training) was developed that captures heart activity over one to five minutes using photoplethysmography (PPG) and derives HR and HRV features. HRV4Training integrated a guide for an early morning spot measurement protocol and a questionnaire to capture self-reported training activity. The smartphone application was made publicly available for interested users to quantify training effect...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267366/eveningness-associates-with-smoking-and-sleep-problems-among-pregnant-women
#18
Ilona Merikanto, E Juulia Paavonen, Outi Saarenpää-Heikkilä, Tiina Paunio, Timo Partonen
Sleep problems during pregnancy impair maternal health and increase the risk for adverse pregnancy outcome. The circadian preference toward eveningness has been associated with sleep problems in previous studies. Here, we studied whether evening-type women had more sleep problems during their pregnancy, as compared with other chronotypes, in a sample consisting of 1653 pregnant women from the Finnish CHILD-SLEEP Birth Cohort. Chronotype was assessed with a shortened version of the morningness-eveningness questionnaire...
March 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28267364/sudden-death-circadian-rhythm-in-chagasic-patients-compared-to-non-chagasic-patients
#19
Juan Marques, Iván Mendoza, Claudia Suárez, Federico Moleiro, Iván Mendoza-Britto, Maria Marques-Mejías
Chagas disease (Ch) affects 8-10 million people in Latin America, most of them are poor. Sudden death (SD) is the major cause of death in patients with Ch. To the best of our knowledge, the present report covers the largest reported series comparing the SD of Ch versus non-Ch patients Objective: To compare the circadian rhythm of SD in Ch versus non-Ch patients. METHODS: Retrospective analysis of all the cases of SD recorded in our department, including autopsied patients from 1963 until 2011...
March 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28263676/survival-and-dna-damage-in-plant-seeds-exposed-for-558-and-682-days-outside-the-international-space-station
#20
David Tepfer, Sydney Leach
For life to survive outside the biosphere, it must be protected from UV light and other radiation by exterior shielding or through sufficient inherent resistance to survive without protection. We tested the plausibility of inherent resistance in plant seeds, reporting in a previous paper that Arabidopsis thaliana and tobacco (Nicotiana tabacum) seeds exposed for 558 days outside the International Space Station (ISS) germinated and developed into fertile plants after return to Earth. We have now measured structural genetic damage in tobacco seeds from this EXPOSE-E experiment by quantitatively amplifying a segment of an antibiotic resistance gene, nptII, inserted into the chloroplast genome...
March 2017: Astrobiology
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