keyword
https://read.qxmd.com/read/38534748/use-of-collagen-in-cosmetic-products
#1
REVIEW
Barbara Jadach, Zofia Mielcarek, Tomasz Osmałek
Collagen (CLG) belongs to the family of fibrillar proteins and is composed of left-handed α polypeptide chains, which, twisting around themselves and their axis, form a right-handed superhelix. In the chemical structure, it contains mainly proline, hydroxyproline, glycine, and hydroxylysine. It occurs naturally in the dermis in the form of fibers that provide the skin with proper density and elasticity. The review aimed to present the types of collagen protein, factors affecting its structure and its unusual role in the functioning of the human body...
March 4, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38526569/the-beneficial-roles-of-sargassum-spp-in-skin-disorders
#2
JOURNAL ARTICLE
Min-Kyeong Lee, Hyeon Hak Jeong, Myeong-Jin Kim, Jae Seong Seo, Ji Young Hwang, Won-Kyo Jung, Kyoung Mi Moon, Incheol Lee, Bonggi Lee
As the body's largest organ, the skin is located at the internal and external environment interface, serving as a line of defense against various harmful stressors. Recently, marine-derived physiologically active ingredients have attracted considerable attention in the cosmeceutical industry due to their beneficial effects on skin health. Sargassum , a genus of brown macroalgae, has traditionally been consumed as food and medicine in several countries and is rich in bioactive compounds such as meroterpenoids, sulfated polysaccharides, fucoidan, fucoxanthin, flavonoids, and terpenoids...
March 22, 2024: Journal of Medicinal Food
https://read.qxmd.com/read/38522682/polysaccharides-from-shell-waste-of-shellfish-and-their-applications-in-the-cosmeceutical-industry-a-review
#3
REVIEW
Nilesh Nirmal, Didem Demir, Seda Ceylan, Sameer Ahmad, Gulden Goksen, Pankaj Koirala, Gioacchino Bono
Shell waste from shellfish processing contains valuable natural polysaccharides, including sulfated polysaccharides, acidic polysaccharides, glycosaminoglycans, chitin and their derivatives. These shellfish waste-derived polysaccharides have numerous functional and biological properties that can be applied in various industries, including the cosmeceutical industry. In keeping with global sustainability and green industry trends, the cosmeceuticals industry is transitioning from petrochemical-based ingredients to natural substitutes...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38508086/phyto-cosmeceutical-gel-containing-curcumin-and-quercetin-loaded-mixed-micelles-for-improved-anti-oxidant-and-photoprotective-activity
#4
JOURNAL ARTICLE
Monica Rp Rao, Pranjali Gaikwad, Poonam Misal, Santosh V Gandhi
Ultra Violet radiations induced skin damage and associated skin disorders are a widespread concern. The consequences of sun exposure include a plethora of dermal conditions like aging, solar urticaria, albinism and cancer. Sunscreens provide effective protection to skin from these damages. Besides FDA approved physical and chemical UV filters, phytoconstituents with their multi functionalities are emerging as frontrunners in Therapy of skin disorders. Objective of this study was to develop novel phyto-dermal gel (PDG) with dual action of sun protection and antioxidant potential using polymeric mixed micelles (PMMs) are nanocarriers...
March 12, 2024: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/38505264/profiling-of-petroselinum-sativum-mill-fuss-phytoconstituents-and-assessment-of-their-biocompatibility-antioxidant-anti-aging-wound-healing-and-antibacterial-activities
#5
JOURNAL ARTICLE
Ismail Mahdi, Paola Imbimbo, Hassan Annaz, Widad Ben Bakrim, Nihad Sahri, Asmae Alaoui, Daria Maria Monti, Mansour Sobeh
Petroselinum sativum , known as parsley, is a fragrant herb that possesses a rich heritage of utilization in traditional medicinal practices. In this study, we annotated the phytocontents of the aqueous and ethanolic extracts of P. sativum and investigated their antioxidant, cytoprotective, antiaging, wound healing, and antibacterial activities. LC-MS/MS analysis of both extracts revealed the presence of 47 compounds belonging to diverse groups including organic acids, phenolic acids, and flavonoids. By MTT assay, the extracts were fully biocompatible on immortalized human keratinocytes (HaCaT) while they inhibited intracellular ROS formation (DCFDA assay) and prevented GSH depletion (DTNB assay) upon UVA exposure...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38496272/chemical-structures-biological-activities-and-medicinal-potentials-of-amine-compounds-detected-from-aloe-species
#6
REVIEW
Adamu Tizazu Yadeta
Unrestricted interest in Aloe species has grown rapidly, and a lot of research is currently being done to learn more about the properties of the various Aloe constituents. Organic compounds containing amine as functional group are present in a vivid variety of compounds, namely, amino acids, hormones, neurotransmitters, DNA, alkaloids, dyes, etc. These compounds have amine functional groups that have various biological activities, which make them responsible for medicinal potential in the form of pharmaceutical, nutraceutical, and cosmeceutical applications...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38495545/evaluation-of-antioxidants-ability-to-enhance-hyaluronic-acid-based-topical-moisturizers
#7
JOURNAL ARTICLE
Joshua Zeichner, Tanja Bussmann, Julia M Weise, Elisabeth Maass, Andrea Krüger, Anne-Kathleen Schade, Edward Lain, Kavita Mariwalla, Frank Kirchner, Zoe D Draelos
BACKGROUND: Hyaluronic acid (HA) is a unique molecule of the extracellular matrix with multiple biological activities. In skin, HA plays an essential role as a humectant, capable of binding up to 1,000 times its mass with water, providing skin with moisture and viscoelastic properties. HA concentration and synthesis decrease significantly in aging skin, due to exogenous and endogenous factors, including photoaging and HA metabolism. A key driver for HA degradation and reduced concentration is mediated via induction of reactive oxygen species (ROS) and other free radicals...
March 2024: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/38494875/in-vitro-evaluation-of-skin-related-enzyme-inhibitory-effect-and-emulgel-formulation-development-studies-of-onobrychis-argyrea-subsp-argyrea-with-phytochemical-analysis
#8
JOURNAL ARTICLE
Tuğba Buse Şentürk, Timur Hakan Barak, Emre Şefik Çağlar, Ebru Özdemir Nath, Zafer Ömer Özdemir
Species of Onobrychis have been used to treat skin disorders such as wounds and cuts in folk medicine and Onobrychis argyrea subsp. argyrea (OA) commonly known as 'silvery sainfoin', is a member of this genus. In this study, it was aimed to investigate the skin-related biological activities and phytochemical characterization of OA. Moreover, an emulgel formulation was developed from the main methanolic extract of the plant (OAM). Initially, to identifiy of the active fractions, aerial parts of the plant material was extracted with methanol and fractionated by n-hexane, chloroform, ethyl acetate and n-butanol, respectively...
March 17, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38478847/3d-bioprinted-human-skin-model-recapitulating-native-like-tissue-maturation-and-immunocompetence-as-an-advanced-platform-for-skin-sensitization-assessment
#9
JOURNAL ARTICLE
Bibrita Bhar, Eshani Das, Kodieswaran Manikumar, Biman B Mandal
Physiologically-relevant in vitro skin models hold utmost importance for efficacy assessments of pharmaceutical and cosmeceutical formulations, offering valuable alternatives to animal testing. Here, we present an advanced immunocompetent three-dimensional (3D) bioprinted human skin model to assess skin sensitization. Initially, a photopolymerizable bioink is formulated using silk fibroin methacrylate, gelatin methacrylate, and photoactivated human platelet releasate. The developed bioink shows desirable physicochemical and rheological attributes for microextrusion bioprinting...
March 13, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38475901/eyelash-serums-a-comprehensive-review
#10
REVIEW
Maya Baiyasi, Kayla St Claire, Meredith Hengy, Komal Tur, Fatima Fahs, Geoffrey Potts
BACKGROUND: Eyelash serums, both prescription and over-the-counter, are gaining popularity for enhancing the appearance of eyelashes through various biologically active molecules. Categorized into prostaglandin analogs and non-prostaglandin analogs, these serums claim increased strength, length, luster, and thickness. Current United States law also requires no efficacy or safety assessments by the Food and Drug Administration before approving products for consumer use, potentially posing health risks for patients seeking over-the-counter eyelash enhancements...
March 12, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38470817/retro-inverso-collagen-modulator-peptide-derived-from-serpin-a1-with-enhanced-stability-and-activity-in-vitro
#11
JOURNAL ARTICLE
Fosca Errante, Marco Pallecchi, Gianluca Bartolucci, Elena Frediani, Francesca Margheri, Lisa Giovannelli, Anna M Papini, Paolo Rovero
The rising demand for novel cosmeceutical ingredients has highlighted peptides as a significant category. Based on the collagen turnover modulation properties of SA1-III, a decapeptide derived from a serine protease inhibitor (serpin A1), this study focused on designing shorter, second-generation peptides endowed with improved properties. A tetrapeptide candidate was further modified employing the retro-inverso approach that uses d-amino acids aiming to enhance peptide stability against dermal enzymes. Surprisingly, the modified peptide AAT11RI displayed notably high activity in vitro, as compared to its precursors, and suggested a mode of action based on the inhibition of collagen degradation...
March 12, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38465749/microneedles-a-novel-clinical-technology-for-evaluating-skin-characteristics
#12
JOURNAL ARTICLE
Seo Hyeong Kim, Ji Hye Kim, Yoon Mi Choi, Su Min Seo, Eun Young Jang, Sung Jae Lee, Suhyun Cho, Do Hyeon Jeong, Kwang Hoon Lee
BACKGROUND: Current methods for evaluating efficacy of cosmetics have limitations because they cannot accurately measure changes in the dermis. Skin sampling using microneedles allows identification of skin-type biomarkers, monitoring treatment for skin inflammatory diseases, and evaluating efficacy of anti-aging and anti-pigmentation products. MATERIALS AND METHODS: Two studies were conducted: First, 20 participants received anti-aging treatment; second, 20 participants received anti-pigmentation treatment...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38465216/ginseng-root-derived-exosome-like-nanoparticles-protect-skin-from-uv-irradiation-and-oxidative-stress-by-suppressing-activator-protein-1-signaling-and-limiting-the-generation-of-reactive-oxygen-species
#13
JOURNAL ARTICLE
Wooram Choi, Jeong Hun Cho, Sang Hee Park, Dong Seon Kim, Hwa Pyoung Lee, Donghyun Kim, Hyun Soo Kim, Ji Hye Kim, Jae Youl Cho
BACKGROUND: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. METHODS: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 109 particles/mL), and followed by UVB irradiation or H2 O2 exposure...
March 2024: Journal of Ginseng Research
https://read.qxmd.com/read/38456790/unlocking-the-potential-of-olive-residues-for-functional-purposes-update-on-human-intervention-trials-with-health-and-cosmetic-products
#14
REVIEW
Emily P Laveriano-Santos, Anna Vallverdú-Queralt, Rajeev Bhat, Anna Tresserra-Rimbau, Eulàlia Gutiérrez-Alcalde, Francesc M Campins-Machado, Rosa M Lamuela-Raventós, Maria Pérez
Olive mill waste (OMW) is a promising source of valuable compounds such as polyphenols, terpenes, sterols, and other bioactive compounds, which are of interest to the pharmaceuticals and cosmeceutical industries. This review examines the potential of OMW extracts for health and beauty applications based on evidence reports from human clinical trials. The results achieved to date indicate health-enhancing properties, but little is known about the underlying mechanisms of action, dose-response relationships, and long-term impacts...
March 8, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38454588/cosmeceuticals-a-transit-state-from-synthetic-to-natural
#15
JOURNAL ARTICLE
Sathyabama Sathyaseelan, Bhavana Hemantha Rao, S Anushmati
Cosmeceuticals are topically applied cosmetic products containing a biologically active ingredient with a pharmaceutical effect that improves, nourishes, and treats the skin appearance. The trend of cosmeceuticals began during the mid-20th century due to its potent ingredients with therapeutic effects for various skin ailments. Even though there is a great advancement in cosmetics, which shows the risk of cosmetic linked melanoma, endocrine disorders, and birth defects which was one in 1500 people during 1935 have increased to one in 75 people in 2000...
January 1, 2024: Indian Journal of Pharmacology
https://read.qxmd.com/read/38450959/a-pilot-study-on-the-efficacy-of-a-seaweed-mud-application-in-the-treatment-of-cellulite
#16
JOURNAL ARTICLE
Domenico Amuso, Alessandro Medoro, Giovanni Scapagnini, Angela Gambacorta, Sergio Davinelli, Eugenio Luigi Iorio, Luca Reggiani Bonetti, Andrea Sbarbati
BACKGROUND: Cellulite represents a common multi-factorial condition that affects nearly all women and is now recognized as a clinical condition associated with systemic factors and negative psychological effects. Several noninvasive and minimally invasive treatments were developed during the last few years, but limited evidence supports many of them due to lack of evidence, insufficient participants, and potential adverse effects. METHODS: This study aimed to evaluate the efficacy of a seaweed mud application in improving both the structure and function of tissues affected by cellulite...
March 7, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38444422/a-multi-center-trial-evaluating-a-serum-comprised-of-plant-based-adaptogens-targeting-skin-quality
#17
JOURNAL ARTICLE
Zoe Diana Draelos, Pearl E Grimes, Jacqueline Watchmaker, Diane B Nelson
OBJECTIVE: The ability of the skin to maintain homeostasis declines with age. Adaptogens support the capacity of the skin to respond to stress. We sought to evaluate the efficacy of a novel serum comprised of plant-based adaptogens for improving photoaged skin following twice-daily application. METHODS: A multi-center, 12-week trial was conducted in participants aged 45 to 65 years, Fitzpatrick Skin Type (FST) I to VI, with mild-to-severe photoaging based on a 10-point grading scale (3 [Minimum] to 7 [Maximum])...
February 2024: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/38440280/innovative-snail-mucus-extract-sme-coated-nanoparticles-exhibit-anti-inflammatory-and-anti-proliferative-effects-for-potential-skin-cancer-prevention-and-treatment
#18
JOURNAL ARTICLE
Consoli Valeria, Petralia Salvatore, Vanella Luca, Gulisano Maria, Maugeri Ludovica, Satriano Cristina, Montenegro Lucia, Castellano Angela, Sorrenti Valeria
Nowadays, several studies have highlighted the ability of snail mucus in maintaining healthy skin conditions due to its emollient, regenerative and protective properties. In particular, mucus derived from H. aspersa muller has been reported to have beneficial effects such as antioxidant, antimicrobial activity and wound repair capacity. To enhance antioxidant activity of snail mucus, it was extracted in a hydroalcoholic solution and consequently freeze-dried. The obtained snail mucus extract (SME) was indeed endowed with higher antioxidant activity observed in cell-free models, however it was not possible to test its effects in cellular models as it creates a thick film on the cell surface...
February 29, 2024: RSC Advances
https://read.qxmd.com/read/38424412/nanocosmeceuticals-trends-and-recent-advancements-in-self-care
#19
REVIEW
Mitali Sethi, Rafquat Rana, Sharda Sambhakar, Manish K Chourasia
The term cosmetics refers to any substances or products intended for external application on the skin with the aim of protection and better appearance of the skin surface. The skin delivery system promotes the controlled and targeted delivery of active ingredients. The development of this system has been driven by challenges encountered with conventional cosmeceuticals, including low skin retention of active components, limited percutaneous penetration, poor water dispersion of insoluble active ingredients, and instability of effective components...
February 29, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38423403/antibacterial-activity-and-mechanism-of-cell-free-supernatants-of-lacticaseibacillus-paracasei-against-propionibacterium-acnes
#20
JOURNAL ARTICLE
Jiahui Xu, Xiaoyong Chen, Jiajia Song, Chen Wang, Weiping Xu, Han Tan, Huayi Suo
Propionibacterium acnes (P. acnes) is an anaerobic and gram-positive bacterium involved in the pathogenesis and inflammation of acne vulgaris. This study particularly focuses on the antimicrobial effect of Lacticaseibacillus paracasei LPH01 against P. acnes, a bacterium that causes acne vulgaris. Fifty-seven Lactobacillus strains were tested for their ability to inhibit P. acnes growth employing the Oxford Cup and double dilution methods. The cell-free supernatant (CFS) of L. paracasei LPH01 demonstrated a strong inhibitory effect, with an inhibition zone diameter of 24...
February 27, 2024: Microbial Pathogenesis
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