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https://www.readbyqxmd.com/read/29659405/the-safety-and-efficacy-of-treatment-with-a-1-927-nm-diode-laser-with-and-without-topical-hydroquinone-for-facial-hyperpigmentation-and-melasma-in-darker-skin-types
#1
Monique J Vanaman Wilson, Isabela T Jones, Joanna Bolton, Lisa Larsen, Sabrina Guillen Fabi
BACKGROUND: The nonablative, fractional, 1,927-nm diode laser is theoretically a safe and effective treatment for hyperpigmentation and melasma in darker skin and may potentiate topical cosmeceutical delivery. OBJECTIVE: To evaluate the use of a nonablative, fractional, 1,927-nm diode laser with and without topical 2% hydroquinone (HQ) cream for moderate-to-severe facial hyperpigmentation in Fitzpatrick skin Types III-V. METHODS: Forty adults underwent 4 laser treatments at 2-week intervals and were randomized to daily application of 2% HQ cream or moisturizer...
April 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29616618/the-antiwrinkle-and-antimelanogenic-effects-of-the-nonedible-part-of-sorghum-bicolor-l-moench-and-their-augmentation-by-fermentation
#2
Da Eun Lee, Jeong Eun Kwon, Eui Su Choung, Sung Ryul Lee, Se Chan Kang
Sorghum [ Sorghum bicolor (L.) Moench] is a major cereal crop. Despite the wide cultivation of sorghum, its stalks are used as hay and silage. The plant has numerous bioactive compounds including cosmeceutical ingredients. Thus, we investigated the antimelanogenic and SSE that is prepared from the stalk of Sorghum bicolor L. (SSE) after ethanol (EtOH) extraction. Based on the antioxidant capacity, antityrosinase activity, and suppression of the protein expression levels of matrix metalloproteinase (MMP)-1, -2, and -3 in human neonatal foreskin HDF-N cells, a 50% EtOH extraction of SSEs showed antimelanogenic and antiwrinkle potential...
July 2017: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29611443/nano-titanium-exposure-induces-dose-and-size-dependent-cytotoxicity-on-human-epithelial-lung-and-colon-cells
#3
Durgaiah Gandamalla, Harikiran Lingabathula, Narsimhareddy Yellu
The productions as well as use of Titanium dioxide nanoparticles (TNPs) were rapidly increasing in the present nano-world. The TNP becomes an inevitable part our daily life in the form of cosmeceutical, bio-medical, and nano-pharmaceutical applications. The TNPs are either inhaled or ingested into the human body through common routes of exposure like the lungs and the oral-gastrointestinal tract (GIT). Human lung and colon were exposed to test particles, TNP 18 nm (TNP 18), TNP 30 nm (TNP 30), and TNP 87 nm (TNP 87) with a dose range 0...
April 3, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29566423/a-prospective-clinical-and-instrumental-study-on-the-effects-of-a-transcutaneous-cosmeceutical-gel-that-is-claimed-to-produce-co2
#4
Gustavo H Leibaschoff, Luis Coll, Wendy E Roberts
Carboxytherapy is the therapeutic use of carbon dioxide (CO2) in its gaseous state. Since 1933, carboxytherapy has referred to either the subcutaneous injection of CO2 or percutaneous application in a warm bath. The present clinical study was performed to determine if there were any changes in the dermis after the application of a transcutaneous gel, which is claimed to produce CO2, and, if so, how these changes compared to those with CO2 injection. Ten patients received transcutaneous treatment with the gel on one side of the face and the other side without any product was used as a control...
March 22, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29565312/development-of-phaleria-macrocarpa-scheff-boerl-fruits-using-response-surface-methodology-focused-on-phenolics-flavonoids-and-antioxidant-properties
#5
Khurul Ain Mohamed Mahzir, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi
In this study, the optimal conditions for the extraction of antioxidants from the Buah Mahkota Dewa fruit ( Phaleria macrocarpa) was determined by using Response Surface Methodology (RSM). The optimisation was applied using a Central Composite Design (CCD) to investigate the effect of three independent variables, namely extraction temperature (°C), extraction time (minutes) and extraction solvent to-feed ratio (% v / v ) on four responses: free radical scavenging activity (DPPH), ferric ion reducing power assay (FRAP), total phenolic content (TPC) and total flavonoid content (TFC)...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29538284/identification-of-the-nadph-oxidase-4-inhibiting-principle-of-lycopus-europaeus
#6
Silvia Revoltella, Giorgia Baraldo, Birgit Waltenberger, Stefan Schwaiger, Philipp Kofler, Julia Moesslacher, Astrid Huber-Seidel, Konrad Pagitz, Roland Kohl, Pidder Jansen-Duerr, Hermann Stuppner
NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable source for the identification of novel bioactive natural products with anti-ageing effects, especially substances that protect plants against UV radiation, which is also known to contribute to the ageing of human skin. Therefore, the aim of this study was to identify novel Nox4 inhibitors from alpine plants...
March 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29524287/antiaging-and-antioxidant-effects-of-topical-autophagy-activator-a-randomized-placebo-controlled-double-blinded-study
#7
Jongmi Lim, Chae Jin Lim, Sungwoo Kim, Gaewon Nam, Minyoul Chang, Keedon Park, Kyungho Park, Hyun Jung Kim, Jeong Keun Ahn, Sekyoo Jeong
BACKGROUND: Recently, potential roles of autophagy in skin homeostasis received many interests. But, little has been reported for the potential antiaging effects of autophagy activator. OBJECTIVE: With the newly synthesized autophagy activator, heptasodium hexacarboxymethyl dipeptide-12 (Aquatide™) in vitro and clinical efficacy of the topical autophagy activator as an antiaging cosmeceutical ingredient was evaluated. METHODS: Antioxidant effect of Aquatide™ was evaluated by radical scavenging assay...
March 9, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29461133/natural-options-for-management-of-melasma-a-review
#8
Mpofana Nomakhosi, Abrahamse Heidi
A blemish free, even-toned skin is universally associated with healthy skin. This reasoning makes people desire to have a flawless skin. Melanin is a naturally occurring pigment in humans. This pigment is responsible for skin, hair, and eye color, therefore determines our race and phenotypic appearance. On darker skin types, it is common that melanin production processes malfunctions. These malfunctions often lead to overproduction and secretion of melanin. As a result, unwanted pigmentary problems such melasma occur...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29446743/recent-advances-in-antioxidant-cosmeceutical-topical-delivery
#9
Shymaa Hatem, Maha Nasr, Seham A Elkheshen, Ahmed S Geneidi
Antioxidants are among the most important cosmeceuticals, with proven ability of inhibiting cellular damage. The topical skin administration of antioxidants is essential for minimizing skin aging and achieving better skin protection against harmful free radicals. However, their unfavorable physiochemical properties such as chemical instability, excessive hydrophilicity or lipophilicity and others could be a great obstacle against their skin promising effects as well as their delivery to deeper skin layers. These problems could all be remedied through the use of delivery carriers...
February 14, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29445569/glutathione-for-skin-lightening-a-regnant-myth-or-evidence-based-verity
#10
Sidharth Sonthalia, Abhijeet K Jha, Aimilios Lallas, Geraldine Jain, Deepak Jakhar
The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a "wonder" drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the unbridled and prodigal use of it, especially as a parenteral formulation, seems unjustified, given the lacunae in our knowledge about its antimelanogenic potential, limited clinical evidence favoring its role in skin lightening, and the statutory ban/advisory issued by certain federal agencies...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29438785/low-molecular-weight-keratins-with-anti-skin-aging-activity-produced-by-anaerobic-digestion-of-poultry-feathers-with-fervidobacterium-islandicum-aw-1
#11
Inhyuk Yeo, Yong-Jik Lee, Kyeongseop Song, Hyeon-Su Jin, Jae-Eun Lee, Dajeong Kim, Dong-Woo Lee, Nam Joo Kang
Bioactive peptides contribute to various cellular processes including improved skin physiology. Hence, bioactive keratins have attracted considerable attention as active cosmetic ingredients for skin health. Here, we obtained low molecular weight (LMW) keratins from native chicken feathers by anaerobic digestion with an extremely thermophilic bacterium Fervidobacterium islandicum AW-1, followed by stepwise fractionation through ultrafiltration. To assess the effects of the feather keratins on skin health, we performed in vitro and ex vivo assays to investigate their inhibitory effects on matrix metalloproteinases (MMPs)...
February 10, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29430629/recent-advances-and-development-in-epidermal-and-dermal-drug-deposition-enhancement-technology
#12
Babar Iqbal, Javed Ali, Sanjula Baboota
Skin is the largest and easily accessible organ of the body. Increases in incidences of dermatological disorders, demand for drug targeting, and patient compliance have increased the popularity of topical drug delivery amongst the people. However, drug delivery across the skin is still a challenge for researchers because permeation of maximum drugs is hindered by the upper layer of the epidermis (stratum corneum). Several approaches like use of chemical permeation enhancers and physical methods such as sonophoresis, iontophoresis, electroporation, microneedles, etc...
February 12, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29385660/protection-of-radiation-induced-dna-damage-by-functional-cosmeceutical-poly-gamma-glutamate
#13
Yu-Jin Oh, Mi-Sun Kwak, Kwang Kim, Moon-Hee Sung
Poly-gamma-glutamate (γ-PGA), an anionic polymer of glutamic acid bonded by γ-amide linkages, is a very promising biodegradable polymer isolated from the Bacillus subtilis sp. Chungkookjang found in Korean fermented food. γ-PGA is useful in a wide range of industrial fields, such as food, cosmetics, and medicine as it is water-soluble, anionic, biodegradable, and edible. In this study, we compared the radioprotective effects of high-molecular-weight 3,000 kDa γ-PGA and reduced form of glutathione (GSH known as radioprotector) on DNA damage...
February 1, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29370540/industrial-potential-of-carotenoid-pigments-from-microalgae-current-trends-and-future-prospects
#14
Ranga Rao Ambati, Deepika Gogisetty, Ravishankar Gokare Aswathanarayana, Sarada Ravi, Panduranga Narasimharao Bikkina, Lei Bo, Su Yuepeng
Microalgae are rich source of various bioactive molecules such as carotenoids, lipids, fatty acids, hydrocarbons, proteins, carbohydrates, amino acids, etc. and in recent year's carotenoids from algae gained commercial recognition in the global market for food and cosmeceutical applications. However, the production of carotenoids from algae is not yet fully cost effective to compete with synthetic ones. In this context the present review examines the technologies/methods in relation to mass production of algae, cell harvesting for extraction of carotenoids, optimizing extraction methods etc...
January 25, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29363245/the-use-of-natural-ingredients-in-innovative-korean-cosmeceuticals
#15
REVIEW
Margit Lw Juhász, Melissa K Levin, Ellen S Marmur
BACKGROUND: The cosmeceutical industry is an ever-growing and in demand market, especially in Asia. Korea has been on the forefront of creating the newest generation and most innovative cosmeceuticals products including ingredients such as snail secretions, starfish powder, botanical extracts, green tea, and red ginseng. Given their increasing prevalence in the cosmeceutical industry, scientists have been conducting investigations into these extracts and their properties. OBJECTIVE: To summarize the current literature surrounding multiple natural ingredients found in Korean cosmeceutical products...
January 24, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29348726/photoaging-protective-effects-of-biogf1k-a-compound-k-rich-fraction-prepared-from-panax-ginseng
#16
Yo Han Hong, Donghyun Kim, Gibaeg Nam, Sulgi Yoo, Sang Yun Han, Seong-Gu Jeong, Eunji Kim, Deok Jeong, Keejung Yoon, Sunggyu Kim, Junseong Park, Jae Youl Cho
Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29344769/sensitive-synchronous-spectrofluorimetric-study-of-certain-sunscreens-using-fluorescence-enhancers-in-cosmeceutical-formulations
#17
Maha F Abdel-Ghany, Miriam F Ayad, Neven N Mikawy
Synchronous spectrofluorimetric methods could be successfully adopted for simultaneous determination of Octinoxate (OMC), Avobenzone (AVO), Octyltriazone (OT), and Phenyl benzimidazole sulfonic acid (PBSA) in moisturizing sunscreen lotion, utilizing β-CD as fluorescence enhancer, and determination of Avobenzone (AVO), Homosalate, Tinosorb M and Phenyl benzimidazole sulfonic acid (PBSA) in presence of Octocrylene (OCR) in whitening sunscreen cream, using micellar medium of Sodium Dodecyl Sulfate (SDS) to enhance fluorescence intensity...
January 17, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29278211/evaluation-of-the-nutraceutical-and-cosmeceutical-potential-of-two-cultivars-of-rubus-fruticosus-l-under-different-cultivation-conditions
#18
Maria Papaioanou, Evangelia G Chronopoulou, Gheorghii Ciobotari, Rodica C Efrose, Liliana Sfichi-Duke, Marianna Chatzikonstantinou, Evangelia Pappa, Ioannis Ganopoulos, Panagiotis Madesis, Irini Nianiou-Obeidat, Taofen Zeng, Nikolaos E Labrou
BACKGROUND: The starting point for the development of new, functional products derived from Rubus fruticosus L. is to determine the optimal cultivation conditions that produce maximal yield of fruits containing desirable bioactive properties. Towards that goal, the effect of soil, soil/peat mixture and light intensity on the nutraceutical and cosmeceutical potential of two cultivars ('Thornfree' and 'Loch Ness') of Rubus fruticosus L. were evaluated. METHODS: The assessment was carried out employing a range of methods for evaluating fruit properties associated with promoting good health such as total antioxidant capacity, secondary metabolites content (vitamin C, polyphenols, flavonoids and anthocyanins) and inhibition analysis of skin-regulating enzymes...
2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29168774/carotenoids-from-marine-organisms-biological-functions-and-industrial-applications
#19
REVIEW
Christian Galasso, Cinzia Corinaldesi, Clementina Sansone
As is the case for terrestrial organisms, carotenoids represent the most common group of pigments in marine environments. They are generally biosynthesized by all autotrophic marine organisms, such as bacteria and archaea, algae and fungi. Some heterotrophic organisms also contain carotenoids probably accumulated from food or partly modified through metabolic reactions. These natural pigments are divided into two chemical classes: carotenes (such as lycopene and α- and β-carotene) that are composed of hydrogen and carbon; xanthophylls (such as astaxanthin, fucoxanthin and lutein), which are constituted by hydrogen, carbon and oxygen...
November 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29165474/sugar-and-mineral-enriched-fraction-from-olive-mill-wastewater-for-promising-cosmeceutical-application-characterization-in-vitro-and-in-vivo-studies
#20
Maria Domenica Di Mauro, Barbara Tomasello, Roberta Carla Giardina, Sandro Dattilo, Veronica Mazzei, Fulvia Sinatra, Massimo Caruso, Nicola D'Antona, Marcella Renis
Nowadays, agro-food by-products represent a potential low-cost source of biologically active ingredients which have been paid significant attention as nutraceuticals, medicine, food and cosmetics. In a previous study we evaluated the total sugars, metals and polyphenols of olive mill wastewater (OMWW) from a Cerasuola olive cultivar. In the present work we selectively recovered a sugar and mineral enriched fraction (SMEF) from Cerasuola OMWW by a green adsorption/desorption process. The SMEF was mainly found to be composed of monosaccharides and potassium by HPLC-ELSD and ICP-MS...
December 13, 2017: Food & Function
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