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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/28935976/tgf-%C3%AE-1-suppresses-ccl3-4-expression-through-the-erk-signaling-pathway-and-inhibits-intervertebral-disc-degeneration-and-inflammation-related-pain-in-a-rat-model
#1
Jian Zhang, Zemin Li, Fan Chen, Hui Liu, Hua Wang, Xiang Li, Xianguo Liu, Jianru Wang, Zhaomin Zheng
The objective of this study was to investigate the regulatory effects of TGF-β1 on CCL3/4 expression and inflammation-related pain during intervertebral disc degeneration (IVDD). TGF-β1 and CCL3/4 expression patterns in different degenerative human nucleus pulposus (NP) tissues were measured by qPCR and immunohistochemistry (IHC), and the effects of TGF-β1 on CCL3/4 expression were measured by qPCR, ELISA and immunofluorescence. The roles of NF-κB and MAPK in TGF-β1-mediated CCL3/4 promoter activity were studied using siRNAs, western blotting and qPCR...
September 22, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28925497/the-feasibility-of-the-cd271-and-cd271-mesenchymal-stromal-cell-enrichment-toward-nucleus-pulposus-like-cells
#2
Katarzyna Jezierska-Wozniak, Monika Barczewska, Aleksandra Habich, Pawel Wojtacha, Wanda Badowska, Wojciech Maksymowicz, Joanna Wojtkiewicz
INTRODUCTION: Factors promoting nerve cell ingrowth are considered responsible for chronic back pain resulting from the intervertebral disc degeneration (IDD). One of the recent exploratory IDD treatments is stem cell transplantation therapy. The CD271 (low-affinity nerve growth factor receptor) has been identified as a marker of the most homogeneous mesenchymal stem cell (MSC) subset. It is capable of promoting differentiation along adipogenic, osteogenic and chondrogenic lineages and producing significantly higher levels of cytokines as compared to the total population of plastic adherence-mesenchymal stem cells (PA-MSCs)...
September 19, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28917706/the-effects-of-needle-damage-on-annulus-fibrosus-micromechanics
#3
Claudio Vergari, Jessica C Mansfield, Daniel Chan, Andrew Clarke, Judith R Meakin, Peter C Winlove
Needle puncture of the intervertebral disc can initiate a mechanical and biochemical cascade leading to disc degeneration. Puncture's mechanical effects have been shown near the puncture site, mechanical effects should be observed far, relative to needle size, from the puncture site, given the disc-wide damage induced by the stab. The aim of this work was to quantify these far-field effects, and to observe the local structural damage provoked by the needle. Strips of cow tail annulus fibrosus underwent two consecutive mechanical loadings to 5% tensile strain; fifteen samples were punctured in a radial direction with a randomly assigned needle between the two loadings (needle gauges between 19 and 23)...
September 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28915718/the-pi3k-akt-pathway-a-critical-player-in-intervertebral-disc-degeneration
#4
REVIEW
Zhi-Hua Ouyang, Wen-Jun Wang, Yi-Guo Yan, Bing Wang, Guo-Hua Lv
Intervertebral disc degeneration (IDD) is thought to be the primary cause of low back pain, a severe public health problem worldwide. Current therapy for IDD aims to alleviate the symptoms and does not target the underlying pathological alternations within the disc. Activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway protects against IDD, which is attributed to increase of ECM content, prevention of cell apoptosis, facilitation of cell proliferation, induction or prevention of cell autophagy, alleviation of oxidative damage, and adaptation of hypoxic microenvironment...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915712/formation-function-and-exhaustion-of-notochordal-cytoplasmic-vacuoles-within-intervertebral-disc-current-understanding-and-speculation
#5
REVIEW
Feng Wang, Zeng-Xin Gao, Feng Cai, Arjun Sinkemani, Zhi-Yang Xie, Rui Shi, Ji-Nan Wei, Xiao-Tao Wu
Notochord nucleus pulposus cells are characteristic of containing abundant and giant cytoplasmic vacuoles. This review explores the embryonic formation, biological function, and postnatal exhaustion of notochord vacuoles, aiming to characterize the signal network transforming the vacuolated nucleus pulposus cells into the vacuole-less chondrocytic cells. Embryonically, the cytoplasmic vacuoles within vertebrate notochord originate from an evolutionarily conserved vacuolation process during neurulation, which may continue to provide mechanical and signal support in constructing a mammalian intervertebral disc...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912585/matrisome-profiling-during-intervertebral-disc-development-and-ageing
#6
Joana Caldeira, Cátia Santa, Hugo Osório, Maria Molinos, Bruno Manadas, Raquel Gonçalves, Mário Barbosa
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation. However, a thorough study of ECM profiling is needed, to better understand IVD development and age-associated degeneration. As so, iTRAQ LC-MS/MS analysis of foetus, young and old bovine NPs, was performed to define the NP matrisome...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28905044/is-there-a-relationship-between-blood-lipids-and-lumbar-disc-herniation-in-young-turkish-adults
#7
Nese Keser, Erhan Celikoglu, Merih İs, Zeynep Demet İlgezdi, Bendigar Sunar, Yusuf Sinan Aydin, Ahmet Ugur Kevenk, Bora Gurer, Ali Fatih Ramazanoglu, Nurgul Keser
INTRODUCTION: Atherosclerosis might diminish the nutrient supply to intervertebral discs (IVD), leading to disc herniation. Therefore, there is interest in determining the possible association between the blood lipid profile and lumbar disc herniation (LDH). We aimed to evaluate the association between blood lipids and LDH in a homogeneous group of patients, controlling for age- and sex-specific effects. MATERIAL AND METHODS: This is a case-control study which consisted of 100 individuals (mean age: 41...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28901458/neuroprotective-effects-of-curcumin-alleviate-lumbar-intervertebral-disc-degeneration-through-regulating-the-expression-of-inos-cox%C3%A2-2-tgf%C3%A2-%C3%AE-1-2-mmp%C3%A2-9-and-bdnf-in-a-rat-model
#8
Yuan Hu, Jin-Shu Tang, Shu-Xun Hou, Xiu-Xiu Shi, Jiang Qin, Tie-Song Zhang, Xiao-Jing Wang
Curcumin is a natural product with antimutagenic, antitumor, antioxidant and neuroprotective properties. However, to the best of our knowledge, curcumin has yet to be investigated for the treatment of lumbar intervertebral disc degeneration LIDD). The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)‑2, transforming growth factor (TGF)‑β1/2, matrix metalloproteinase (MMP)‑9 and brain‑derived neurotrophic factor (BDNF) in a rat model of LIDD...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28891440/a-systematic-review-of-mesenchymal-stem-cells-in-spinal-cord-injury-intervertebral-disc-repair-and-spinal-fusion
#9
Shujhat Khan, Pouya Mafi, Reza Mafi, Wasim Khan
Spinal surgery presents a challenge for both neurosurgery and orthopaedic surgery. Due to the heterogeneous differentiation potential of mesenchymal stem cells, there is much interest in the treatment of spine surgery. Animal and human trials focussing on the efficacy of mesenchymal stem cells in spinal cord injury, spine fusion and disc degeneration were included in this systematic review. Published articles up to January 2016 from MEDLINE, PubMed and Ovid were used by searching for specific terms. Of the 2595 articles found, 53 met the selection criteria and were included for analysis (16 on spinal cord injury, 28 on intervertebral disc repair and 9 on spinal fusion)...
September 7, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28887038/resveratrol-protects-against-mitochondrial-dysfunction-through-autophagy-activation-in-human-nucleus-pulposus-cells
#10
Baolong Zhang, Linfei Xu, Naiqiang Zhuo, Jieliang Shen
Intervertebral disc degeneration (IVDD) is closely related with aging, whereas mitochondrial damage is a common feature of aging that results in cell apoptosis. Resveratrol (RES) is a natural antioxidant that protects against mitochondrial dysfunction in various cells. This study aimed to investigate the protective role of RES against mitochondrial dysfunction and human nucleus pulposus cell (NPC) apoptosis. We found that mitochondrial dysfunction and NPC apoptosis could be induced under oxidative stress by 100 μmol/l of H2O2...
September 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28886203/a-novel-method-for-repeatable-failure-testing-of-annulus-fibrosus
#11
Benjamin Werbner, Minhao Zhou, Grace O'Connell
Tears in the annulus fibrosus (AF) of the intervertebral disc can result in herniation of the nucleus pulposus and progressive disc degeneration. Understanding AF failure mechanics is particularly important as research moves towards developing biological repair strategies for herniated discs. Unfortunately, failure mechanics of fiber-reinforced tissues, particularly those with fibers oriented off-axis from the applied load, is not well understood. Therefore, the objective of this study was to investigate the effectiveness of mid-length notch geometries in producing repeatable and consistent tissue failure within the gauge region of AF mechanical test specimens...
September 8, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28884563/expressions-and-significance-of-hif-1%C3%AE-and-aqp-3-in-intervertebral-disc-degeneration-tissues-of-cervical-spondylotic-myelopathy
#12
Xiangqi Tan, Yuqing Chen, Zhuyong Ji
No abstract text is available yet for this article.
September 7, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28881531/-gene-expression-profiles-of-long-non-coding-rnas-in-human-degenerated-intervertebral-disc-tissue
#13
Z Y Sun, P Yan, S J Wang, H Liang, Y Li, D G Wang, J W Tian
Objective: To investigate the gene expression profiles of long non-coding RNAs (lncRNA)in human degenerated intervertebral disc degeneration (IDD). Methods: An lncRNA-mRNA microarray analysis of human nucleus pulposus (NP) was employed. Bioinformatics prediction was also applied to delineate the functional roles of the differentially expressed lncRNAs. Several lncRNAs and mRNAs were chosen for quantitative real-time PCR (qRT-PCR) validation. Results: A total of 1 570 lncRNAs expressed in degenerate group compared with the nondegenerate group...
September 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28874804/whole-transcriptome-analysis-of-notochord-derived-cells-during-embryonic-formation-of-the-nucleus-pulposus
#14
Sun H Peck, Kendra K McKee, John W Tobias, Neil R Malhotra, Brian D Harfe, Lachlan J Smith
Recapitulation of developmental signals represents a promising strategy for treating intervertebral disc degeneration. During development, embryonic notochord-derived cells (NDCs) are the direct progenitors of cells that populate the adult nucleus pulposus (NP) and are an important source of secreted signaling molecules. The objective of this study was to define global gene expression profiles of NDCs at key stages of embryonic disc formation. NDCs were isolated from Shh-cre;ROSA:YFP mice at embryonic day 12...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28870839/long-term-clinical-results-following-charite-iii-lumbar-total-disc-replacement
#15
Shibao Lu, Siyuan Sun, Chao Kong, Wenzhi Sun, Hailiang Hu, Qingyi Wang, Yong Hai
BACKGROUND CONTEXT: The lumbar total disc replacement (TDR) operation represents an alternative to lumbar fusion for the treatment of symptomatic lumbar intervertebral disc degeneration, and has gained increasing attention in recent years. PURPOSE: To assess clinical outcomes in a cohort of patients with TDR and the long-term survival rate of the prostheses. STUDY DESIGN: A retrospective, single-center clinical study. PATIENT SAMPLE: Thirty patients with a total of 35 prostheses after an average follow-up (FU) of 15...
September 1, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28870349/effect-of-axial-vertical-vibration-on-degeneration-of-lumbar-intervertebral-discs-in-modified-bipedal-rats-an-in-vivo-study
#16
Xiao Liang, Hao Shen, Wei-Dong Shi, Shan Ren, Wei Jiang, Hao Liu, Peng Yang, Zhi-Yong Sun, Jun Lin, Hui-Lin Yang
OBJECTIVE: To assess the effects of axial vibrations on gene expression and lumbar intervertebral disc degeneration in vivo. METHODS: A modified bipedal rat model was established using a brachial plexus rhizotomy approach to imitate human upright posture. The experimental animals were randomly divided into three groups: control, vertical vibration, and whole-body vibration. Gene expression in degeneration of the intervertebral discs was assessed by reverse transcription-quantitative polymerase chain reaction...
July 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28866193/injectable-natural-polymer-compound-for-tissue-engineering-of-intervertebral-disc-in-vitro-study
#17
Masoud Ghorbani, Jafar Ai, Mohammad Reza Nourani, Mahmoud Azami, Batool Hashemi Beni, Shiva Asadpour, Sima Bordbar
Intervertebral disc degeneration is recognized to be the leading cause for chronic low-back pain. Injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation specially for intervertebral (IVD) affecting rate of regeneration success, in this study we assessed viscoelastic properties of a Chitosan-β glycerophosphate-hyaluronic acid, Chondroitin-6-sulfate, type 2 of Collagen, gelatin, fibroin silk (Ch-β-GP-HA-CS-Col-Ge-FS) hydrogel which was named as NP hydrogel that is natural extracellular matrix of IVD...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28863414/influence-of-age-bmi-gender-and-lumbar-level-on-t1%C3%AF-magnetic-resonance-imaging-of-lumbar-discs-in-healthy-asymptomatic-adults
#18
Raphael Gübitz, Tobias Lange, Georg Gosheger, Walter Heindel, Thomas Allkemper, Christoph Stehling, Joachim Gerss, Christian Kanthak, Tobias L Schulte
Purpose To assess the T1ρ range of lumbar intervertebral discs in healthy asymptomatic individuals at 1.5 T and to investigate the influence of age, body mass index (BMI), gender, and lumbar level on T1ρ relaxation. Materials and Methods In a prospective study, a total of 81 volunteers aged 20 - 80 years were included in this study and divided into three age groups (A: 20 - 39y; B: 40 - 59y; C: 60 - 80y). All of the volunteers underwent magnetic resonance imaging (MRI) at 1.5 T with acquisition of sagittal T1ρ images...
September 1, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28863006/intervertebral-disc-degeneration-in-a-percutaneous-mouse-tail-injury-model
#19
Zuozhen Tian, Xiaoyuan Ma, Miersalijiang Yasen, Robert L Mauck, Ling Qin, Frances S Shofer, Lachlan J Smith, Maurizio Pacifici, Motomi Enomoto-Iwamoto, Yejia Zhang
OBJECTIVES: Intervertebral disc (IVD) degenerates progressively with age and after injuries. In this study, we aimed to characterize early molecular events underlying disc degeneration using a mouse tail IVD injury model. DESIGN: We have established a transcutaneous minimally invasive approach to induce mouse tail IVD injury under fluoroscopic guidance. Morphological and molecular changes in the injured IVDs are compared with the baseline features of adjacent intact levels...
August 31, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28853606/impact-of-the-quantity-of-intradiscal-cement-leak-on-the-progression-of-intervertebral-disc-degeneration
#20
B Jamjoom, S Patel, R Bommireddy, Z Klezl
Introduction We aim to assess the impact of the quantity of intradiscal cement leak during kyphoplasty on the rate of progression of degenerative changes in the affected disc. Methods Of 316 kyphoplasty procedures, we identified 32 episodes of intradiscal cement leak in 26 patients. The quantity of cement leaked was graded from I to IV. Disc degenerative changes were assessed at presentation and follow-up using radiographical scoring and magnetic resonance imaging (MRI) grading systems. Data for low-grade leaks (grade I) were compared with the medium- and high-grade leaks (grades II-IV) using a chi-squared test...
September 2017: Annals of the Royal College of Surgeons of England
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