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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/28810627/carthamin-yellow-inhibits-matrix-degradation-and-inflammation-induced-by-lps-in-the-intervertebral-disc-via-suppression-of-mapk-pathway-activation
#1
Bin Chen, Han-Tao Wang, Bo Yu, Ji-Dong Zhang, Yu Feng
Carthamin yellow (CY), which is a flavonoid compound isolated from safflower, has various pharmacological effects including promoting blood circulation to remove blood stasis and alleviating pain. CY is a herb used in Chinese traditional medicines. Intervertebral disc degeneration (IDD) is a common spinal disorder and degeneration of nucleus pulposus (NP) cells and inflammation are significant parts of the pathological cascade. The curative effect of CY on NP cells in association with degeneration and inflammation remains to be elucidated...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810608/mechanism-of-microrna-21-regulating-il-6-inflammatory-response-and-cell-autophagy-in-intervertebral-disc-degeneration
#2
Hao Lin, Wenzhi Zhang, Tao Zhou, Wansu Li, Ziao Chen, Chaochao Ji, Chao Zhang, Fang He
This study investigated the mechanism of microRNA-21 in regulating IL-6 inflammatory response and cell autophagy in intervertebral disc degeneration. A total of 10 patients with lumbar disc herniation accompanied by nerve root pain (observation group) and 10 patients with lumbar burst fractures (control group) were selected. The nucleus pulposus tissues of the lesion were obtained during operation for cell culture. Real-time quantitative polymerase chain reaction (PCR) was used to detect the expression of microRNA-21...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810570/research-on-the-function-and-related-mechanism-of-p27-gene-in-the-intervertebral-disc-degeneration-of-mice
#3
Xiao Liu, Deguo Wang, Zhengzheng Zhang, Fenghui Zhu, Aiming Yao, Jiwei Tian, Dengshun Miao
This study aims to investigate the function and related mechanism of P27 gene in intervertebral disc (IVD) degeneration of mice. X-ray, immunohistochemical staining, and alkaline phosphatase (ALP) histochemical staining were used to analyze the phenotypic difference of the intervertebral discs of 4-week-old mice with P27 gene knockout (P27(-/-)) and wild-type (WT) mice in the same brood. Protein in the intervertebral disc was extracted and western blot analysis was employed to detect the changes in the expression of related molecules in the Shh-signal pathways, including Shh, Patched, Smoothened and Gli2...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810568/mechanism-of-microrna-146a-mediated-il-6-stat3-signaling-in-lumbar-intervertebral-disc-degeneration
#4
Tao Zhou, Hao Lin, Ziao Cheng, Chaochao Ji, Chao Zhang, Jiwei Tian
The aim of the study was to investigate the mechanism of microRNA (miR)-146a-mediated activation of interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3) in lumbar intervertebral disc degeneration. To obtain intervertebral tissue, we recruited 5 patients with lumbar intervertebral disc herniation (experimental group) and 5 patients with lumbar burst fracture (control group). Nucleus pulposus tissue was extracted by surgery and cultured. miR-146a empty vector, mimic, and inhibitor were transfected into the two groups of cells for 24 h and the levels of IL-6, type II collagen (Col II), aggrecan, STAT3, matrix metalloproteinase (MMP)-3, and a disintegrin and metalloproteinase with thrombospondin type I motifs (ADAMTS) were detected...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28805297/mesenchymal-stem-cells-deliver-exogenous-mir-21-via-exosomes-to-inhibit-nucleus-pulposus-cell-apoptosis-and-reduce-intervertebral-disc-degeneration
#5
Xiaofei Cheng, Guoying Zhang, Liang Zhang, Ying Hu, Kai Zhang, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zhao
Although mesenchymal stem cells (MSCs) transplantation into the IVD (intervertebral disc) may be beneficial in inhibiting apoptosis of nucleus pulposus cells (NPCs) and alleviating IVD degeneration, the underlying mechanism of this therapeutic process has not been fully explained. The purpose of this study was to explore the protective effect of MSC-derived exosomes (MSC-exosomes) on NPC apoptosis and IVD degeneration and investigate the regulatory effect of miRNAs in MSC-exosomes and associated mechanisms for NPC apoptosis...
August 14, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28799804/morphologic-features-of-spontaneous-annular-tears-and-disc-degeneration-in-the-aging-sand-rat-psammomys-obesus-obesus
#6
H E Gruber, E N Hanley
The sand rat, a member of the gerbil family, is a valuable small animal model in which intervertebral disc degeneration occurs spontaneously as the animal ages. Radiographic features of cervical and lumbar degeneration resemble those in human spines. We conducted a retrospective analysis of spines of 140 animals 3-41 months old focusing specifically on the presence of annular tears that are not visible by radiography and have not been described previously in the sand rat disc. During degeneration of the nucleus pulposus, notochordal cell death occurs and granular material, which stains with Alcian blue for proteoglycans, accumulates...
August 11, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28797134/looking-beyond-the-intervertebral-disc-the-need-for-behavioral-assays-in-models-of-discogenic-pain
#7
REVIEW
Grace E Mosley, Thomas W Evashwick-Rogler, Alon Lai, James C Iatridis
Orthopedic research into chronic discogenic back pain has commonly focused on aging- and degeneration-related changes in intervertebral disc structure, biomechanics, and biology. However, the primary spine-related reason for physician office visits is pain. The ambiguous nature of the human condition of discogenic low back pain motivates the use of animal models to better understand the pathophysiology. Discogenic back pain models must consider both emergent behavioral changes following pain induction and changes in the nervous system that mediate such behavior...
August 10, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28793234/microrna-132-upregulation-promotes-matrix-degradation-in-intervertebral-disc-degeneration
#8
Wei Liu, Ping Xia, Jing Feng, Liang Kang, Mi Huang, Kun Wang, Yu Song, Shuai Li, Xinghuo Wu, Shuhua Yang, Cao Yang
MicroRNAs (miRNAs) have been shown to be involved in the pathogenesis of intervertebral disc degeneration (IDD). This experiment was designed to study the expression and role of the miRNA, miR-132, in IDD. MiR-132 expression in human nucleus pulposus (NP) tissue was assessed by quantitative real-time PCR. The methylation status of the miR-132 was assessed with methylation-specific PCR and bisulfite sequencing PCR. The regulation of growth differentiation factor5 (GDF5) expression by miR-132 was evaluated by luciferase reporter assay...
August 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28769985/long-term-course-to-lumbar-disc-resorption-patients-and-predictive-factors-associated-with-disc-resorption
#9
Jinho Lee, Joowon Kim, Joon-Shik Shin, Yoon Jae Lee, Me-Riong Kim, Seon-Yeong Jeong, Young-Jun Choi, Tae Kyung Yoon, Byung-Heon Moon, Su-Bin Yoo, Jungsoo Hong, In-Hyuk Ha
The long-term course to lumbar intervertebral disc herniation (LDH) patients receiving integrative Korean medicine treatment and predictive factors associated with disc resorption were investigated. LDH patients who received integrative Korean medicine treatment from February 2012 to December 2015 and were registered in the "longitudinal project for LDH on MRI" were included. Disc resorption amount was measured 3-dimensionally with disc degeneration and modic change levels on baseline and follow-up MRIs. Patient characteristics, Korean medicine use, pain, symptom recurrence, and satisfaction were assessed through medical records and phone surveys...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28767622/adiponectin-down-regulates-tnf-%C3%AE-expression-in-degenerated-intervertebral-discs
#10
Bin Yuan, Liangliang Huang, Ming Yan, Shilei Zhang, Yongfeng Zhang, Boquan Jin, Ying Ma, Zhuojing Luo
STUDY DESIGN: Given the results of previous in vitro investigations of the expression patterns of adiponectin and its receptors in healthy and degenerated intervertebral discs (IVDs), we studied the effects of adiponectin on TNF-α production in degenerated nucleus pulposus (NP) cells and analyzed the association between adiponectin levels in IVD tissues and IVD Pfirrmann grades. OBJECTIVE: investigate the potential role of adiponectin in the pathogenesis of IVD degeneration...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28765874/upregulation-of-nuclear-factor%C3%A2-%C3%AE%C2%BAb-and-acid-sensing-ion-channel-3-in-dorsal-root-ganglion-following-application-of-nucleus-pulposus-onto-the-nerve-root-in-rats
#11
Dong Wang, Hao Pan, Hang Zhu, Li Zhu, Yong-Jiang He, Jian Wang, Gao-Yong Jia
The nucleus pulposus (NP) is an avascular, hydrated tissue that permits the intervertebral disc to resist compressive loads to the spine. To determine the mechanisms by which intervertebral disc degeneration is caused by the nucleus pulposus, the expression and regulation of nuclear factor (NF)‑κB and acid sensing ion channel 3 (ASIC3) were examined. For the intervertebral disc degeneration model, NP was harvested from the tail of rats and applied to the L5 dorsal root ganglion (DRG). The mechanical pain withdrawal threshold (PWT) in NP model rats was assessed...
July 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764746/percutaneous-endoscopic-lumbar-discectomy-minimally-invasive-technique-for-multiple-episodes-of-lumbar-disc-herniation
#12
Kyung-Chul Choi, Jin-Sung Kim, Dong Chan Lee, Choon-Keun Park
BACKGROUNDS: Although open lumbar discectomy is a gold standard surgical technique for lumbar disc herniation (LDH), surgery-induced tissue injury may actually become a source of postsurgical pain. Percutaneous endoscopic lumbar discectomy (PELD) is introduced as a minimal invasive spinal technique for LDH. The PELD has gained popularity and shown successful results. The authors report the clinical usefulness of the PELD technique in two patients with the serial multilevel LDHs. CASE PRESENTATIONS: A 32-year-old man suffered from radicular pain at the L5 dermatome due to the down migrated soft LDH at the L4-5 level...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28762133/origins-and-neurochemical-characteristics-of-porcine-intervertebral-disc-sympathetic-innervation-a-preliminary-report
#13
Monika Barczewska, Judyta Juranek, Joanna Wojtkiewicz
Intervertebral disc diseases (IVDDs) form a group of a vertebral column disorders affecting a large number of people worldwide. It is estimated that approximately 30% of individuals at the age of 35 and approximately 90% of individuals at the age of 60 and above will have some form of disc-affecting pathological changes leading to disc herniation, prolapse and degeneration as well as discogenic pain. Here, we aimed to establish the origins and neurochemical characteristics of porcine intervertebral disc sympathetic innervation involved in pain signalling in IVDD patients...
July 31, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28756222/role-of-lncrna-tug1-in-intervertebral-disc-degeneration-and-nucleus-pulposus-cells-via-regulating-wnt-%C3%AE-catenin-signaling-pathway
#14
Jiang Chen, Yu-Song Jia, Gen-Zhe Liu, Qi Sun, Fan Zhang, Sheng Ma, Yong-Jun Wang
OBJECTIVE: To investigate the role of TUG1 in intervertebral disc degeneration (IDD) and human nucleus pulposus cells (NPCs) via regulating Wnt/β-catenin pathway. METHODS: The study collected nucleus pulposus (NP) tissue samples from 30 patients with lumbar disc herniation (LDH) (Case group) and 18 patients with lumbar spine trauma (Control group). NPCs induced by TNF-α in vitro were divided into Blank, Vector, TUG1, TUG1-siRNA, XAV-939, TUG1 + XAV-939 groups...
July 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28752097/efficacy-of-platelet-rich-plasma-in-retarding-intervertebral-disc-degeneration-a-meta-analysis-of-animal-studies
#15
Pei Li, Ruijie Zhang, Qiang Zhou
OBJECTIVES: Several animal studies have demonstrated the positive effects of platelet-rich plasma (PRP) on disc degeneration retardation. The present meta-analysis was to verify the efficacy of PRP in retarding disc degeneration in animal. METHODS: Relevant studies were identified and evaluated according to our inclusion and exclusion criteria. The standardized mean difference (SMD) and related 95% confidence interval (95% CI) were estimated to assess PRP efficiency...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28749857/vertebral-endplate-defect-as-initiating-factor-in-intervertebral-disc-degeneration-strong-association-between-endplate-defect-and-disc-degeneration-in-the-general-population
#16
Marinko Rade, Juhani H Määttä, Maxim B Freidin, Olavi Airaksinen, Jaro Karppinen, Frances Mk Williams
STUDY DESIGN: Cross-sectional study of spine MR in a population, predominantly female, sample. OBJECTIVE: To determine the relationship between vertebral endplate defect and intervertebral disc degeneration (DD) in general population. SUMMARY OF BACKGROUND DATA: Precise understanding of the mechanisms leading to DD development is lacking. In a degenerating disc, mechanical and structural changes lead to further worsening of disc integrity...
July 26, 2017: Spine
https://www.readbyqxmd.com/read/28744842/the-quantitative-structural-and-compositional-analyses-of-degenerating-intervertebral-discs-using-magnetic-resonance-imaging-and-contrast-enhanced-micro-computed-tomography
#17
Kevin H Lin, Simon Y Tang
The intervertebral disc (IVD) is susceptible to degenerative changes that are associated with low back pain. Murine models are often used to investigate the mechanistic changes in the development, aging, and diseased states of the IVD, yet the detection of early degenerative changes in structure is challenging because of the minute size of the murine IVDs. Histology is the gold standard for examining the IVD structure, but it is susceptible to sectioning artifacts, spatial biases, and requires the destructive preparation of the sample...
July 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28736380/-association-of-fasl-844t-c-gene-polymorphism-with-fasl-expression-in-the-nucleus-pulposus-of-degenerative-lumbar-intervertebral-discs
#18
Zheng-Ming Sun, Pengmaojiacuo Pengmaojiacuo, Hong-Hai Xu, Yan-Hai Chang, Xue-Yuan Wu, Xiang-Hui Dong, Ming Ling
OBJECTIVE: To investigate the association of FasL-844T/C gene polymorphism with the magnetic resonance imaging (MRI) findings and FasL expression in the nucleus pulposus of degenerative lumbar intervertebral discs. METHODS: Lumbar MRI data, venous blood and nucleus pulposus were collected from 105 patients with lumbar disc herniation. The genotypes of FasL-844T/C gene of the patients were determined using matrix-assisted laser desorption ionization time-of-flight mass spectrometry...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735027/translation-of-an-injectable-triple-interpenetrating-network-hydrogel-for-intervertebral-disc-regeneration-in-a-goat-model
#19
Sarah E Gullbrand, Thomas P Schaer, Prateek Agarwal, Justin R Bendigo, George R Dodge, Weiliam Chen, Dawn M Elliott, Robert L Mauck, Neil R Malhotra, Lachlan J Smith
Degeneration of the intervertebral discs is a progressive cascade of cellular, compositional and structural changes that is frequently associated with low back pain. As the first signs of disc degeneration typically arise in the disc's central nucleus pulposus (NP), augmentation of the NP via hydrogel injection represents a promising strategy to treat early to mid-stage degeneration. The purpose of this study was to establish the translational feasibility of a triple interpenetrating network hydrogel composed of dextran, chitosan, and teleostean (DCT) for augmentation of the degenerative NP in a preclinical goat model...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28733922/effect-of-collagen-fibre-orientation-on-intervertebral-disc-torsion-mechanics
#20
Bo Yang, Grace D O'Connell
The intervertebral disc is a complex fibro-cartilaginous material, consisting of a pressurized nucleus pulposus surrounded by the annulus fibrosus, which has an angle-ply structure. Disc injury and degeneration are noted by significant changes in tissue structure and function, which significantly alters stress distribution and disc joint stiffness. Differences in fibre orientation are thought to contribute to changes in disc torsion mechanics. Therefore, the objective of this study was to evaluate the effect of collagen fibre orientation on internal disc mechanics under compression combined with axial rotation...
July 21, 2017: Biomechanics and Modeling in Mechanobiology
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