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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/28339441/the-role-of-the-ligamentum-flavum-area-as-a-morphological-parameter-of-lumbar-central-spinal-stenosis
#1
Young Uk Kim, Jun Young Park, Doo Hwan Kim, Myung-Hwan Karm, Jae-Young Lee, Jee In Yoo, Sung Won Chon, Jeong Hun Suh
BACKGROUND: Hypertrophy of the ligamentum flavum (LF) has been considered as a major cause of lumbar central spinal stenosis (LCSS). Previous studies have found that ligamentum flavum thickness (LFT) is correlated with aging, disc degeneration, and lumbar spinal stenosis. However, hypertrophy is different from thickness. Thus, to evaluate hypertrophy of the whole LF, we devised a new morphological parameter, called the ligamentum flavum area (LFA). OBJECTIVES: We hypothesized that the LFA is a key morphologic parameter in the diagnosis of LCSS...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28326305/implications-for-a-stem-cell-regenerative-medicine-based-approach-to-human-intervertebral-disk-degeneration
#2
REVIEW
Petra Kraus, Thomas Lufkin
The human body develops from a single cell, the zygote, the product of the maternal oocyte and the paternal spermatozoon. That 1-cell zygote embryo will divide and eventually grow into an adult human which is comprised of ~3.7 × 10(13) cells. The tens of trillions of cells in the adult human can be classified into approximately 200 different highly specialized cell types that make up all of the different tissues and organs of the human body. Regenerative medicine aims to replace or restore dysfunctional cells, tissues and organs with fully functional ones...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28321567/adjacent-segment-pathology-natural-history-or-effect-of-anterior-cervical-discectomy-and-fusion-a-10-year-follow-up-radiological-multicenter-study-using-an-evaluation-scale-of-the-ageing-spine
#3
Alessandro Pesce, Venceslao Wierzbicki, Emanuele Piccione, Alessandro Frati, Antonino Raco, Riccardo Caruso
PURPOSE: Aim of this study is to compare late degenerative MRI changes in a subset of patients operated on with ACDF to a second subset of patients presenting indication to ACDF but never operated on. METHODS: Patients from both subgroups received surgical indication according to the same criteria. Both subgroups underwent a cervical spine MRI in 2004-2005 and 10 years later in 2015. These MRI scans were retrospectively evaluated with a cervical spine ageing scale...
March 20, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28321409/could-the-topping-off-technique-be-the-preventive-strategy-against-adjacent-segment-disease-after-pedicle-screw-based-fusion-in-lumbar-degenerative-diseases-a-systematic-review
#4
REVIEW
Po-Hsin Chou, Hsi-Hsien Lin, Howard S An, Kang-Ying Liu, Wei-Ren Su, Cheng-Li Lin
The "topping-off" technique is a new concept applying dynamic or less rigid fixation such as hybrid stabilization device (HSD) or interspinous process device (IPD) for the purpose of avoiding adjacent segment disease (ASD) proximal to the fusion construct. A systematic review of the literature was performed on the effect of topping-off techniques to prevent or decrease the occurrence of ASD after lumbar fusion surgery. We searched through major online databases, PubMed and MEDLINE, using key words related to "topping-off" technique...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28321270/autophagy-is-a-protective-response-to-the-oxidative-damage-to-endplate-chondrocytes-in-intervertebral-disc-implications-for-the-treatment-of-degenerative-lumbar-disc
#5
Ke Chen, Xiaohua Lv, Wei Li, Fei Yu, Jianjing Lin, Junxuan Ma, Deming Xiao
Low back pain (LBP) is the leading cause of disability in the elderly. Intervertebral disc degeneration (IDD) was considered as the main cause for LBP. Degeneration of cartilaginous endplate was a crucial harmful factor during the initiation and development of IDD. Oxidative stress was implicated in IDD. However, the underlying molecular mechanism for the degeneration of cartilaginous endplate remains elusive. Herein, we found that oxidative stress could induce apoptosis and autophagy in endplate chondrocytes evidenced by western blot analysis, flow cytometry, immunofluorescence staining, GFP-LC3B transfection, and MDC staining...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28298159/biological-behavior-of-human-nucleus-pulposus-mesenchymal-stem-cells-in-response-to-changes-in-the-acidic-environment-during-intervertebral-disc-degeneration
#6
Jianjun Liu, Hui Tao, Cailiang Shen, Xiaoying Liu, Hanbang Wang, Fulong Dong, Renjie Zhang, Jie Li, Peng Ge, Peiwen Song, Huaqing Zhang, Peng Xu
An acidic environment is vital for the maintenance of cellular activities but can be affected tremendously during intervertebral disc degeneration. The effect of changes in the acidity of the environment on human nucleus pulposus mesenchymal stem cells (NP-MSCs) is unknown, however. Thus, this study aimed to observe the biological effects of acidic conditions mimicking a degenerated intervertebral disc on NP-MSCs in vitro. NP-MSCs were isolated from patients with lumbar disc herniation and were further identified by their immunophenotypes and multilineage differentiation...
March 16, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28297581/systemic-delivery-of-bone-marrow-mesenchymal-stem-cells-for-in-situ-intervertebral-disc-regeneration
#7
Carla Cunha, Catarina R Almeida, Maria Inês Almeida, Andreia M Silva, Maria Molinos, Sofia Lamas, Catarina L Pereira, Graciosa Q Teixeira, António T Monteiro, Susana G Santos, Raquel M Gonçalves, Mário A Barbosa
Cell therapies for intervertebral disc (IVD) regeneration presently rely on transplantation of IVD cells or stem cells directly to the lesion site. Still, the harsh IVD environment, with low irrigation and high mechanical stress, challenges cell administration and survival. In this study, we addressed systemic transplantation of allogeneic bone marrow mesenchymal stem cells (MSCs) intravenously into a rat IVD lesion model, exploring tissue regeneration via cell signaling to the lesion site. MSC transplantation was performed 24 hours after injury, in parallel with dermal fibroblasts as a control; 2 weeks after transplantation, animals were killed...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296211/deleterious-effects-of-nonsynonymous-single-nucleotide-variants-of-human-il-1%C3%AE-gene
#8
Yue-Hui Zhang, Jia Song, Jing Zhang, Jiang Shao
The IL-1β gene is currently topic of interest for its important role in the pathogenesis of intervertebral disc degeneration. The new sequencing technology makes it crucial to study the effects of variants in IL-1β. Thus, 714 IL-1β variants with evidence supporting were collected from the EMBL database. Among them, 62 were nonsynonymous single nucleotide variants (nsSNVs). Furthermore, six common nsSNVs were predicted to have damaging effects by SIFT, PolyPhen, PROVEAN and SNPs&GO. Based on the constructed three-dimensional structure of pro-IL-1β, rs375479974 with a mutation of Phe to Ser was proposed to reduce the stability of the pro-IL-1β protein...
March 15, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28289843/micro-ct-evaluation-of-asymmetrical-ovine-intervertebral-disc-height-loss-from-surgical-approach
#9
Christopher Ludtka, Stefan Schwan, Andrea Friedmann, Walther Brehm, Ingo Wiesner, Felix Goehre
PURPOSE: The primary goal of this study is to clearly define and evaluate new intervertebral disc height parameters in analysing the morphological pathology of disc degeneration for application in damage model and regeneration therapy development, as well as applying traditional variables to 3-D characterization methods. METHODS: A posterolateral surgical approach was used to induce disc degeneration in an ovine model. At 12-months post-operation, sheep vertebral segments were removed and characterized using micro-CT to evaluate disc height parameters in regard to injury localization...
March 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28288923/effects-of-alendronateon-lumbar-intervertebral-disc-degeneration-with-bone-loss-in-ovariectomized-rats
#10
Huiping Song, Yang Luo, Wenya Wang, Shuyang Li, Kai Yang, Muwei Dai, Yong Shen, Yingze Zhang, Liu Zhang
BACKGROUND CONTEXT: Osteoporosis adversely affects disc degeneration cascades, and prophylactic alendronate (ALN) helps delay intervertebral disc degeneration (IDD) in ovariectomized (OVX) rats. However, there remains no information regarding whether ALN affects IDD with bone loss. PURPOSE: This study aimed to observe the effects of ALN on degenerative discs with bone loss induced by OVX in rats. STUDY DESIGN: Controlled in vivo experiments in rodents...
March 10, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28285075/thermally-triggered-hydrogel-injection-into-bovine-intervertebral-disc-tissue-explants-induces-differentiation-of-mesenchymal-stem-cells-and-restores-mechanical-function
#11
A A Thorpe, G Dougill, L Vickers, N D Reeves, C Sammon, G Cooper, C L Le Maitre
We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of mesenchymal stem cells (MSCs) to nucleus pulposus (NP) cells without additional growth factors. The clinical success of this hydrogel is dependent on: integration with surrounding tissue; the capacity to restore mechanical function; as well as supporting the viability and differentiation of delivered MSCs. Bovine NP tissue explants were injected with media (control), human MSCs (hMSCs) alone, acellular L-pNIPAM-co-DMAc hydrogel or hMSCs incorporated within the L-pNIPAM-co-DMAc hydrogel and maintained at 5% O2 for 6 weeks...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28266560/3d-characterization-of-morphological-changes-in-the-intervertebral-disc-and-endplate-during-aging-a-propagation-phase-contrast-synchrotron-micro-tomography-study
#12
Yong Cao, Shenghui Liao, Hao Zeng, Shuangfei Ni, Francis Tintani, Yongqiang Hao, Lei Wang, Tianding Wu, Hongbin Lu, Chunyue Duan, Jianzhong Hu
A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a technical challenge. We aim to characterize the 3D morphology changes of endplate and IVD during aging using PPCST. The lumbar vertebral level 4/5 IVDs harvested from 15-day-, 4- and 24-month-old mice were initially evaluated by PPCST with histological sections subsequently analyzed to confirm the imaging efficiency...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262607/biomechanics-of-the-human-intervertebral-disc-a-review-of-testing-techniques-and-results
#13
REVIEW
N Newell, J P Little, A Christou, M A Adams, C J Adam, S D Masouros
Many experimental testing techniques have been adopted in order to provide an understanding of the biomechanics of the human intervertebral disc (IVD). The aim of this review article is to amalgamate results from these studies to provide readers with an overview of the studies conducted and their contribution to our current understanding of the biomechanics and function of the IVD. The overview is presented in a way that should prove useful to experimentalists and computational modellers. Mechanical properties of whole IVDs can be assessed conveniently by testing 'motion segments' comprising two vertebrae and the intervening IVD and ligaments...
January 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28261429/radiological-parameters-of-undegenerated-cervical-vertebral-segments-in-a-korean-population
#14
Sung Hoon Choi, HeeSang Lee, Jae Hwan Cho, Jin Il Jung, Dong-Ho Lee
BACKGROUND: Several scoring systems for cervical disc and facet joint degeneration, using radiography or computed tomography, have been developed and tested for reliability. However, definitions of disc height and facet joint space narrowing vary. To our knowledge, no study has reported quantitative data for normal radiologic values of the cervical spine in the Korean population. The purpose of this study is to determine normal cervical disc height, disc height ratio, and facet joint space values, and investigate the correlation between demographic data and these values...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28256798/the-roles-and-perspectives-of-micrornas-as-biomarkers-for-intervertebral-disc-degeneration
#15
REVIEW
Xiaoya Zhou, Lili Chen, Sibylle Grad, Mauro Alini, Haobo Pan, Dazhi Yang, Wanxin Zhen, Zhizhong Li, Shishu Huang, Songlin Peng
MicroRNAs (miRNAs) are highly conserved molecules that regulate protein levels post-transcriptionally. Aberrant miRNA expression presents in various musculoskeletal disorders, such as osteoporosis, osteoarthritis and rheumatoid arthritis. The expression levels of miRNAs are characterized by endogenous properties and tissue specificity. This raises the possibility that miRNAs could serve as useful clinical biomarkers in the diagnosis of certain diseases. Intervertebral disc degeneration (IDD) is one of the major causes of back pain, and a process characterized by a cascade of molecular, cellular, biochemical and structural changes...
March 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28255267/17beta-estradiol-attenuates-tnf-%C3%AE-induced-premature-senescence-of-nucleus-pulposus-cells-through-regulating-the-ros-nf-%C3%AE%C2%BAb-pathway
#16
Pei Li, Yibo Gan, Yuan Xu, Liyuan Wang, Bin Ouyang, Chengmin Zhang, Lei Luo, Chen Zhao, Qiang Zhou
BACKGROUND: Accelerated cellular senescence within the nucleus pulposus (NP) region is a common feature of disc degeneration. Our previous work indicated that TNF-α promoted NP cell senescence. Although the intervertebral disc has been reported to be an estrogen-sensitive tissue, it is unclear whether estrogen can inhibit premature senescence of NP cells. OBJECTIVE: To investigate whether 17beta-estradiol (E2) can attenuate TNF-α-induced premature senescence of NP cells and the potential mechanism behind this regulatory process...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28254665/early-stage-autophagy-protects-nucleus-pulposus-cells-from-glucose-deprivation-induced-degeneration-via-the-p-eif2%C3%AE-atf4-pathway
#17
Hongze Chang, Feng Cai, Yan Zhang, Mintao Xue, Liang Liu, Anli Yang, Xiaodong Liu
Autophagy is a double-edged sword in cellular survival, but its effects on nucleus pulposus (NP) cells are yet to be clarified. This study explored the role and molecular mechanisms of autophagy in the survival of NP cells under nutrient deprivation. Glucose limitation induced time-dependent morphological changes, proteoglycan degradation, and apoptosis in NP cells. Glucose deprivation triggered the activation of early-stage autophagy, evident as increases in LC3-II and ATG12-ATG5 expression and the number of GFP-LC3 puncta...
February 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28253483/factors-that-influence-recurrent-lumbar-disc-herniation
#18
M E Yaman, A Kazancı, N D Yaman, F Baş, G Ayberk
INTRODUCTION: The most common cause of poor outcome following lumbar disc surgery is recurrent herniation. Recurrence has been noted in 5% to 15% of patients with surgically treated primary lumbar disc herniation. There have been many studies designed to determine the risk factors for recurrent lumbar disc herniation. In this study, we retrospectively analysed the influence of disc degeneration, endplate changes, surgical technique, and patient's clinical characteristics on recurrent lumbar disc herniation...
March 3, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28240653/paraspinal-muscle-passive-stiffness-remodels-in-direct-response-to-spine-stiffness-a-study-using-the-ent1-deficient-mouse
#19
Kelsey Y Gsell, Derek P Zwambag, Dale E Fournier, Cheryle A Séguin, Stephen H M Brown
STUDY DESIGN: Basic science study of the relationship between the structural properties of the spine and its surrounding musculature. OBJECTIVE: To determine if an increase in spine stiffness causes an inverse compensatory change in the passive stiffness of the adjacent paraspinal muscles. SUMMARY OF BACKGROUND DATA: Intervertebral disc degeneration causes an increase in multifidus passive stiffness; this was hypothesized to compensate for a decrease in spine stiffness associated with disc degeneration...
February 24, 2017: Spine
https://www.readbyqxmd.com/read/28224704/advanced-glycation-end-products-regulate-anabolic-and-catabolic-activities-via-nlrp3-inflammasome-activation-in-human-nucleus-pulposus-cells
#20
Yu Song, Yan Wang, Yukun Zhang, Wen Geng, Wei Liu, Yong Gao, Shuai Li, Kun Wang, Xinghuo Wu, Liang Kang, Cao Yang
Intervertebral disc degeneration is widely recognized as a cause of lower back pain, neurological dysfunction and other musculoskeletal disorders. The major inflammatory cytokine IL-1β is associated with intervertebral disc degeneration; however, the molecular mechanisms that drive IL-1β production in the intervertebral disc, especially in nucleus pulposus (NP) cells, are unknown. In some tissues, advanced glycation end products (AGEs), which accumulate in NP tissues and promote its degeneration, increase oxidative stress and IL-1β secretion, resulting in disorders, such as obesity, diabetes mellitus and ageing...
February 22, 2017: Journal of Cellular and Molecular Medicine
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