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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/28719551/annulus-fibrosus-repair-using-high-density-collagen-gel-an-in-vivo-ovine-model
#1
Brenton Pennicooke, Ibrahim Hussain, Connor Berlin, Stephen R Sloan, Brandon Borde, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez, Jonathan Cheetham, Lawrence J Bonassar, Roger Härtl
STUDY DESIGN: Ovine in vivo study. OBJECTIVE: To perform lateral approach lumbar surgery in an ovine model to administer an injectable riboflavin (RF) cross-linked high-density collagen (HDC) gel and to assess its ability to mitigate intervertebral disc (IVD) degeneration after induced annulus fibrosus (AF) injury. SUMMARY OF BACKGROUND DATA: Biological-based injectable gels have shown efficacy in restoring biomechanical, radiographic, and histological parameters in IVD-injured animal models...
July 17, 2017: Spine
https://www.readbyqxmd.com/read/28719048/developmental-mechanisms-of-intervertebral-disc-and-vertebral-column-formation
#2
REVIEW
Lisa Y Lawson, Brian D Harfe
The vertebral column consists of repeating units of ossified vertebrae that are adjoined by fibrocartilagenous intervertebral discs. These structures form from the embryonic notochord and somitic mesoderm. In humans, congenital malformations of the vertebral column include scoliosis, kyphosis, spina bifida, and Klippel Feil syndrome. In adulthood, a common malady affecting the vertebral column includes disc degeneration and associated back pain. Indeed, recent reports estimate that low back pain is the number one cause of disability worldwide...
July 18, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28719035/melatonin-inhibits-nucleus-pulposus-np-cell-proliferation-and-extracellular-matrix-ecm-remodeling-via-the-melatonin-membrane-receptors-mediated-pi3k-akt-pathway
#3
Zheng Li, Xingye Li, Chong Chen, Matthew T V Chan, William Ka Kei Wu, Jianxiong Shen
Pinealectomy in vertebrates accelerated intervertebral disc degeneration (IDD). However, the potential mechanisms, particularly, melatonin's role is still to be clarified. In this study, for first time, melatonin membrane receptors of MT1 and MT2 were found to be present in the human intervertebral disc tissues and nucleus pulposus (NP) cells, respectively. Melatonin treatment significantly inhibited NP cell proliferation in dose- dependent manner. Accordingly, melatonin down-regulated gene expression of cyclin D1, PCNA, matrix metallopeptidases-3 and -9 and upregulated gene expression of collagen type II alpha 1 chain and aggrecan in NP cells...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28716711/epigenetic-silencing-of-mirna-143-regulates-apoptosis-by-targeting-bcl2-in-human-intervertebral-disc-degeneration
#4
Kangcheng Zhao, Yukun Zhang, Kang Liang, Yu Song, Kun Wang, Shuai Li, Xinghuo Wu, Wenbin Hua, Zengwu Shao, Shuhua Yang, Cao Yang
Accumulating evidence indicates that microRNAs can regulate the apoptosis of various cells. Apoptosis of nucleus pulposus cells plays an important role in the progression of intervertebral disc degeneration. The aim of this study is to investigate whether microRNA-143 (miRNA-143) is involved in the progression of intervertebral disc degeneration. In this study, the expression of miRNA-143 and its biological modulatory effects were examined. Messenger RNA and protein expression of miRNA-143 and B-cell lymphoma-2 (BCL2) in both normal and degenerative disc tissues was determined by using RT-PCR and western-blot assays...
July 14, 2017: Gene
https://www.readbyqxmd.com/read/28715865/chitosan-oligosaccharides-protect-nucleus-pulposus-cells-from-hydrogen-peroxide-induced-apoptosis-in-a-rat-experimental-model
#5
Peng Jia, Ling Yu, Chunjie Tao, Guo Dai, Zhengpei Zhang, Shiqing Liu
Chitosan has been investigated for its protective effect on nucleus pulposus (NP) cells against intervertebral disc degeneration(IDD), but its high molecular weight prohibits its clinical application. The low molecular derivatives, chitosan oligosaccharides (COS) are easier to absorb; however, the protective effect of COS against IDD remains unclear. In this study, we investigated the effects of COS on NP degeneration. NP cells derived from rats were treated with H2O2 to induce an IDD-like transition. Then, COS was used to pre-treat cells before administering H2O2 and changes occurring in the cells were observed...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28713050/the-biomechanical-impact-of-the-facet-tropism-on-the-intervertebral-disc-and-facet-joints-in-the-cervical-spine
#6
Xin Rong, Beiyu Wang, Chen Ding, Yuxiao Deng, Hua Chen, Yang Meng, Weijie Yan, Hao Liu
BACKGROUND CONTEXT: The facet tropism is defined as the angular difference between the left and right facet orientation. The facet tropism was suggested to be associated with the disc degeneration and facet degeneration in the lumbar spine. However, little is known about the relationship between the facet tropism and pathological changes in the cervical spine and the mechanism behind. PURPOSE: This study was conducted to investigate the biomechanical impact of the facet tropism on the intervertebral disc and facet joints...
July 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28711584/biomarkers-reflect-differences-in-osteoarthritis-phenotypes-of-the-lumbar-spine-the-johnston-county-osteoarthritis-project
#7
Adam P Goode, Amanda E Nelson, Virginia B Kraus, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA. DESIGN: A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II)...
July 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28709868/protective-effect-of-p53-on-the-viability-of-intervertebral-disc-nucleus-pulposus-cells-under-low-glucose-condition
#8
Xifeng Xiong, Libing Dai, Weiguo Liang, Jinli Zhang, Shengnan Qin, Wenjuan Cao, Dongping Ye, Peihong Liang, Zhihe Liu
P53 is a famous cancer suppressor and plays key roles in metabolism. Intervertebral disc (IVD) is the largest avascular cartilaginous structure in humans and its degeneration is a common cause of spine diseases initiated from damaged nucleus pulposus (NP) cells. The potential cause of disc degeneration has been attributed to aging, genetic factors, mechanical factors and nutrition. In this study, we found that p53 decreased and leaked to the cytoplasm in NP cells as the glucose level decreases, in contrast to cancer cells in which p53 increases and concentrates to the nuclei...
July 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28705727/the-piezo1-protein-ion-channel-functions-in-human-nucleus-pulposus-cell-apoptosis-by-regulating-mitochondrial-dysfunction-and-the-endoplasmic-reticulum-stress-signal-pathway
#9
Xiao-Fei Li, Ping Leng, Zhao Zhang, Hai-Ning Zhang
The Piezo1 protein ion channel is a novel mechanical stretch-activated ion channel (SAC) closely related to mechanical signals. Mechanotransduction plays a crucial role in organ development and homeostasis. Previous studies identified Piezo1 and demonstrated that it is distinct from other ion channels with well-established roles in lower organisms. Mechanical stretch-activated ion channels from other organisms are not conserved in mammals or do not act as mechanically activated channels in mammals. In the current study, we explored the role of the Piezo1 ion channel in human nucleus pulposus cell (NP cell) apoptosis through mechanical force-induced mitochondrial dysfunction and endoplasmic reticulum stress...
July 10, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28685666/mri-findings-of-lumbar-spine-instability-in-degenerative-spondylolisthesis
#10
Il Youp Cho, Si Young Park, Jong Hoon Park, Seung Woo Suh, Soon Hyuck Lee
PURPOSE: To find out the factors suggesting lumbar segmental instability in patients with degenerative spondylolisthesis (DS) on conventional magnetic resonance imaging (MRI). METHODS: Ninety-four patients with DS who underwent decompression surgery with or without fusion were selected. Patient demographics and findings on simple radiographs and MRI were analyzed. We divided patients into two groups by the presence of lumbar instability on simple standing plain radiographs and measured degeneration status of intervertebral discs and facet joints and distance of facet fluid signal on T2 axial MRI on each groups...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28685335/interrelationship-between-silicon-aluminum-and-elements-associated-with-tissue-metabolism-and-degenerative-processes-in-degenerated-human-intervertebral-disc-tissue
#11
Anetta Zioła-Frankowska, Łukasz Kubaszewski, Mikołaj Dąbrowski, Marcin Frankowski
There is a growing body of evidence concerning the significant role of silicon in development and composition of both connective and bone tissue. Bio-essential silicon shows strong chemical and biological affinity to aluminum, which is toxic and biologically inessential element. The presence of silicon was confirmed in a variety of tissues; however, it has never been examined in intervertebral disc tissue, neither in healthy nor in degenerated one. In this paper, for the first time in the literature, we present the content of silicon in the degenerated intervertebral disc tissue...
July 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28682110/is-intervertebral-disc-degeneration-related-to-segmental-instability-an-evaluation-with-two-different-grading-systems-based-on-clinical-imaging
#12
David Volkheimer, Fabio Galbusera, Christian Liebsch, Sabine Schlegel, Friederike Rohlmann, Sebastian Kleiner, Hans-Joachim Wilke
Background Several in vitro studies investigated how degeneration affects spinal motion. However, no consensus has emerged from these studies. Purpose To investigate how degeneration grading systems influence the kinematic output of spinal specimens. Material and Methods Flexibility testing was performed with ten human T12-S1 specimens. Degeneration was graded using two different classifications, one based on X-ray and the other one on magnetic resonance imaging (MRI). Intersegmental rotation (expressed by range of motion [ROM] and neutral zone [NZ]) was determined in all principal motion directions...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28679056/self-healing-dynamic-hydrogel-as-injectable-shock-absorbing-artificial-nucleus-pulposus
#13
Adrián Pérez-San Vicente, Marianna Peroglio, Manuela Ernst, Pablo Casuso, Iraida Loinaz, Hans-Jürgen Grande, Mauro Alini, David Eglin, Damien Dupin
The intervertebral discs (IVDs) provide unique flexibility to the spine and exceptional shock absorbing properties under impact. The inner core of the IVD, the nucleus pulposus (NP) is responsible for this adaptive behavior. Herein, we evaluate an injectable, self-healing dynamic hydrogel (DH) based on gold(I)-thiolate/disulfide (Au-S/SS) exchange as NP replacement in a spine motion segment model. For the first time, we report the application of dynamic covalent hydrogels inside biological tissues. The dynamic exchange between Au-S species and disulfide bonds (SS) resulted in self-healing ability and frequency-dependent stiffness of the hydrogel, which was also confirmed in spine motion segments...
July 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28678109/age-correlated-phenotypic-alterations-in-cells-isolated-from-human-degenerated-intervertebral-discs-with-contained-hernias
#14
Maria Molinos, Carla Cunha, Catarina R Almeida, Raquel M Gonçalves, Paulo Pereira, Pedro Santos Silva, Rui Vaz, Mário A Barbosa
STUDY DESIGN: Human intervertebral disc (hIVD) cells were isolated from 41 surgically excised samples and assessed for their phenotypic alterations with age. OBJECTIVE: Towards the design of novel anti-ageing strategies to overcome degenerative disc disease (DDD), we investigated age-correlated phenotypic alterations that occur on primary hIVD cells. SUMMARY OF BACKGROUND DATA: Although regenerative medicine holds great hope, much is still to be unveiled on IVD cell biology and its intrinsic signalling pathways, which can lead the way to successful therapies for IDD...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28678107/intervertebral-disc-degeneration-during-postoperative-follow-up-more-than-10-years-after-corrective-surgery-in-idiopathic-scoliosis-comparison-between-patients-with-and-without-surgery
#15
Ayato Nohara, Noriaki Kawakami, Taichi Tsuji, Tetsuya Ohara, Toshiki Saito, Kazuki Kawakami
STUDY DESIGN: Retrospective comparative Study OBJECTIVE.: To evaluate the difference in trends of disc degeneration (DD) at Lower unfused segments (LUS) for post-operative patients who have gone through spinal instrumentation at 10-year follow-up with the natural progression of idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Studies that used MRI state that DD rates at LUS are higher than in the normal population. However, current studies do not prove that surgery is the most effective clinical method to treat idiopathic scoliosis, as no existing report compares the rates of DD with the natural history of idiopathic scoliosis...
July 3, 2017: Spine
https://www.readbyqxmd.com/read/28677762/general-regulatory-effects-of-hypoxia-on-human-cartilage-endplate%C3%A2-derived-stem-cells-a-genome%C3%A2-wide-analysis-of-differential-gene-expression-and-alternative-splicing-events
#16
Yuan Yao, Weilin Song, Qiyue Deng, Huiyu Zhang, Jian Wang, Huan Liu, Yue Zhou
Intervertebral disc (IVD) degeneration of is considered to be initiated by the degeneration of the cartilage endplate (CEP). CEP‑derived stem cells (CESCs) with the capacity for osteochondrogenic differentiation may be responsible for CEP cartilage restoration. As CEP is avascular and hypoxic, and hypoxia can greatly influence biological activities of stem cells, physiological hypoxia may serve important roles in regulating the physiological functions of CESCs. The aim of the present study was to investigate the mechanisms of hypoxia‑regulated CESCs fate by using the Human Transcriptome Array 2...
June 30, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28670416/correlation-among-inflammatory-cytokine-expression-levels-degree-of-disk-degeneration-and-predominant-clinical-symptoms-in-patients-with-degenerated-intervertebral-discs
#17
Takeshi Sainoh, Kazuhide Inage, Sumihisa Orita, Masao Koda, Takeo Furuya, Kazuyo Yamauchi, Miyako Suzuki, Yoshihiro Sakuma, Go Kubota, Yasuhiro Oikawa, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Kazuhisa Takahashi, Seiji Ohtori
STUDY DESIGN: Observational study. PURPOSE: To assess the correlation among inflammatory cytokine expression levels, degree of intervertebral disk (IVD) degeneration, and predominant clinical symptoms observed in degenerative disk disease (DDD). OVERVIEW OF LITERATURE: Low back pain (LBP) is associated with inflammatory cytokine expression levels, including those of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and nerve growth factor (NGF)...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28670405/intradiscal-injection-of-autologous-platelet-rich-plasma-releasate-to-treat-discogenic-low-back-pain-a-preliminary-clinical-trial
#18
Koji Akeda, Kohshi Ohishi, Koichi Masuda, Won C Bae, Norihiko Takegami, Junichi Yamada, Tomoki Nakamura, Toshihiko Sakakibara, Yuichi Kasai, Akihiro Sudo
STUDY DESIGN: Preliminary clinical trial. PURPOSE: To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain. OVERVIEW OF LITERATURE: PRP, which is comprised of autologous growth factors and cytokines, has been widely used in the clinical setting for tissue regeneration and repair. PRP has been shown in vitro and in vivo to potentially stimulate intervertebral disc matrix metabolism...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28670402/disc-rehydration-after-dynamic-stabilization-a-report-of-59-cases
#19
Atilla Yilmaz, Salim Senturk, Mehdi Sasani, Tunc Oktenoglu, Onur Yaman, Hakan Yildirim, Tuncer Suzer, Ali Fahir Ozer
STUDY DESIGN: A retrospective study investigating decrease in the nucleus pulposus signal intensity or disc height on magnetic resonance imaging (MRI) and disc degeneration. PURPOSE: Although a degenerated disc cannot self-regenerate, distraction or stabilization may provide suitable conditions for rehydration and possible regeneration. This study aimed to evaluate clinical outcomes and disc regeneration via MRI in a series of patients with degenerative disc disease (DDD) who underwent lumbar stabilization with a dynamic stabilization system (DSS)...
June 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28669721/initial-investigation-of-individual-and-combined-annulus-fibrosus-and-nucleus-pulposus-repair-ex-vivo
#20
Stephen R Sloan, Devis Galesso, Cynthia Secchieri, Connor Berlin, Roger Hartl, Lawrence J Bonassar
Novel tissue engineered and biomaterial approaches to treat intervertebral disc (IVD) degeneration focus on single aspects of the progressive disease and hence are insufficient repair strategies. In this study, annulus fibrosus (AF) and nucleus pulposus (NP) biomaterial repair strategies were used individually and combined to treat IVD degeneration modeled in ex vivo rat-tail motion segments by annulotomy and nucleotomy. An injectable riboflavin cross-linked high-density collagen gel patched defects in the AF, while NP repair consisted of injections of a modified hyaluronic acid (HA) hydrogel...
June 29, 2017: Acta Biomaterialia
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