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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/28432852/correlation-between-expression-of-high-temperature-requirement-serine-protease-a1-htra1-in-nucleus-pulposus-and-t2-value-of-magnetic-resonance-imaging
#1
Dapeng Li, Jiawei Yue, Lu Jiang, Yonghui Huang, Jifu Sun, Yan Wu
BACKGROUND Degrading enzymes play an important role in the process of disc degeneration. The objective of this study was to investigate the correlation between the expression of high temperature requirement serine protease A1 (HtrA1) in the nucleus pulposus and the T2 value of the nucleus pulposus region in magnetic resonance imaging (MRI). MATERIAL AND METHODS Thirty-six patients who had undergone surgical excision of the nucleus pulposus were examined by MRI before surgery. Pfirrmann grading of the target intervertebral disc was performed according to the sagittal T2-weighted imaging, and the T2 value of the target nucleus pulposus was measured according to the median sagittal T2 mapping...
April 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28430387/age-related-reduction-in-the-expression-of-foxo-transcription-factors-and-correlations-with-intervertebral-disc-degeneration
#2
Oscar Alvarez-Garcia, Tokio Matsuzaki, Merissa Olmer, Koichi Masuda, Martin K Lotz
Aging is a main risk factor for intervertebral disc (IVD) degeneration, the main cause of low back pain. FOXO transcription factors are important regulators of tissue homeostasis and longevity. Here, we determined the expression pattern of FOXO in healthy and degenerated human IVD and the associations with IVD degeneration during mouse aging. FOXO expression was assessed by immunohistochemistry in normal and degenerated human IVD samples and in cervical and lumbar IVD from 6, 12, 24, and 36-month-old C57BL/6J mice...
April 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28429362/wnt11-overexpression-promote-adipose-derived-stem-cells-differentiating-to-the-nucleus-pulposus-like-phenotype
#3
H-T Chen, A-B Huang, Y-L He, J Bian, H-J Li
OBJECTIVE: Our present study aimed to evaluate the effects of Wnt11 overexpression on the adipose-derived stem (ADSCs) cells differentiation to the nucleus pulposus (NP) cells and its function in the ADSCs cells growth, proliferation and induction of the NP cells markers. MATERIALS AND METHODS: The cell growth was detected using the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) (MTT) assay and the cell cycle was assessed by the flow cytometry...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28427393/correlation-between-intervertebral-disc-degeneration-paraspinal-muscle-atrophy-and-lumbar-facet-joints-degeneration-in-patients-with-lumbar-disc-herniation
#4
Dong Sun, Peng Liu, Jie Cheng, Zikun Ma, Jingpei Liu, Tingzheng Qin
BACKGROUND: To assess the correlation between lumbar disc degeneration (LDD), multifidus muscle atrophy (LMA), and facet joints degeneration in patients with L4-L5 lumbar disc herniation (LDH). METHODS: Sixty patients with L4-L5 LDH diagnosed by a 1.5 T MRI scanner were enrolled in the study group and another 60 patients with non-specific back pain were enrolled in the control group. LDD, LMA, and facet joints degeneration were examined and analyzed independently by two independent orthopedic surgeons using T2-weighted images...
April 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28427186/microrna-494-promotes-apoptosis-and-extracellular-matrix-degradation-in-degenerative-human-nucleus-pulposus-cells
#5
Liang Kang, Cao Yang, Yu Song, Kangcheng Zhao, Wei Liu, Wenbin Hua, Kun Wang, Ji Tu, Shuai Li, Huipeng Yin, Yukun Zhang
PURPOSE: This study investigated the expression and function of the microRNA-494 in intervertebral disc degeneration (IDD). RESULTS: MicroRNA-494 expression was upregulated during IDD progression; its overexpression increased the expression of ECM catabolic factors such as matrix metalloproteinase and A disintegrin and metalloproteinase with thrombospondin motif in NP cells while decreasing that of anabolic genes such as type II collagen and aggrecan; it also induced the apoptosis of NP cells, as determined by flow cytometry...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28425065/changes-in-perfusion-and-diffusion-in-the-endplate-regions-of-degenerating-intervertebral-discs-a-dce-mri-study
#6
Volkan Emre Arpinar, Scott D Rand, Andrew P Klein, Dennis J Maiman, L Tugan Muftuler
No abstract text is available yet for this article.
April 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28416834/-efficacy-of-transforaminal-endoscopic-nerve-root-decompression-in-the-treatment-of-degenerative-lumbar-spinal-stenosis
#7
Z R Yu, C D Li, S N Zhu, H L Sun, Y Zhao, L T Qi
OBJECTIVE: To evaluate the feasibility of transforaminal endoscopic nerve root decompression for degenerative lumbar spinal stenosis (DLSS). METHODS: From July 2011 to April 2016, 96 cases of single segment DLSS were involved. All the patients had unilateral lower extremity neurological symptoms, signs, neurogenic intermittent claudication of less than 500 m. Imaging examinations (CT or MRI) or diagnostic nerve root block confirmed single segment degeneration. The mean age was (71...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28416438/nsaid-use-in-intervertebral-disc-degeneration-what-are-the-effects-on-matrix-homeostasis-in-vivo
#8
Nicholas Vaudreuil, Tiffany Kadow, Takashi Yurube, Robert Hartman, Kevin Ngo, Qing Dong, Pedro Pohl, J Paulo Coelho, James Kang, Nam Vo, Gwendolyn Sowa
BACKGROUND CONTEXT: Non-steroidal anti-inflammatory (NSAID) agents are a widely utilized treatment for low back pain (LBP). Literature on NSAID use in articular cartilage has shown detrimental effects; however, minimal data exist to detail the effects of NSAIDs in intervertebral disc degeneration (IDD). As IDD is a major cause of LBP, we explored the effects of indomethacin, a commonly used NSAID, on disc matrix homeostasis in an animal model of IDD. PURPOSE: To determine the effects of oral indomethacin administration on IDD in an in vivo rabbit model...
April 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28413490/noninvasive-cumulative-axial-load-may-induce-intervertebral-disc-degeneration-a-potential-rabbit-model
#9
Xuedong Bai, Deli Wang, Mingyue Zhou, Cheng Xu, Wei Li, Hui Tao, Qing He, Dike Ruan
Intervertebral disc degeneration (IDD) is considered to be the main cause of many spinal disorders; however, its underlying pathophysiology is not clearly understood. Recent studies indicate that excessive mechanical loading may serve a major role in the initiation of IDD. The aim of the present study was to explore the effect of noninvasive cumulative axial loading on the intervertebral discs of the lumbar spine using a novel rabbit model. Rabbits in the experimental group were placed into individual tubes specifically designed to force maintenance of an upright posture and were loaded with a heavy collar to increase the intradiscal pressure of their lumbar spine...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28411026/drp1-mediates-compression-induced-programmed-necrosis-of-rat-nucleus-pulposus-cells-by-promoting-mitochondrial-translocation-of-p53-and-nuclear-translocation-of-aif
#10
Hui Lin, Lei Zhao, Xuan Ma, Bai-Chuan Wang, Xiang-Yu Deng, Min Cui, Song-Feng Chen, Zeng-Wu Shao
Compression-induced programmed cell death of nucleus pulposus (NP) cells is an important contributor to intervertebral disc degeneration (IDD). Dynamin-related protein 1 (Drp1), a crucial mitochondrial fission protein, triggers programmed necrosis upon cellular injury. However, limited information is available about the role of Drp1 in compression-induced programmed necrosis of NP cells. In the present study, we found that compression resulted in upregulation and mitochondrial translocation of Drp1. Inhibition of Drp1 by siRNA or mitochondrial division inhibitor 1 (mdivi-1) effectively prevented the programmed necrosis of NP cells treated with compression...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28409653/constitutive-expression-of-il-22-in-the-human-intervertebral-disc-and-its-reduction-by-exposure-to-pro-inflammatory-cytokines-in-vitro
#11
H E Gruber, E Marrero, J A Ingram, G L Hoelscher, E N Hanley
The importance of cytokines in disc degeneration is well recognized. Little is known about IL-22 expression in the human intervertebral disc. We investigated IL-22 immuno-localization in disc tissue, and molecular expression and production of IL-22 by annulus cells cultured in three-dimensional (3D) culture. We examined human disc tissue using immunohistochemistry and we cultured isolated annulus cells in 3D to analyze IL-22 expression and production, and its receptor, IL-22R, in conditioned media. Ingenuity pathway analysis (IPA) also was used to identify significant gene expression networks within the molecular data...
2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28404518/nanoparticle-fullerol-alleviates-radiculopathy-via-nlrp3-inflammasome-and-neuropeptides
#12
Li Jin, Mengmeng Ding, Azra Oklopcic, Bayan Aghdasi, Li Xiao, Ziyi Li, Vesna Jevtovic-Todorovic, Xudong Li
The present study aimed to evaluate the analgesic effect of the antioxidant nanoparticle fullerol in a mouse radiculopathy and a dorsal root ganglion (DRG) culture models. Intervertebral disc degeneration causes significant hyperalgesia and nerve inflammation. Pain sensitization and inflammatory reaction were counteracted by fullerol when disc material was bathed in 10 or 100μM of fullerol prior to implantation. Immunohistochemistry showed similar massive IBA1 positive macrophage infiltration surrounding implanted disc material among groups, but IL-1β and IL-6 expression was decreased in fullerol treated group...
April 9, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28402966/an-injectable-nucleus-pulposus-cell-modified-decellularized-scaffold-biocompatible-material-for-prevention-of-disc-degeneration
#13
Zhi Shan, Xianfeng Lin, Shengyu Wang, Xuyang Zhang, Yichuan Pang, Shengyun Li, Tianming Yu, Shunwu Fan, Fengdong Zhao
We developed a nucleus pulposus cell (NPC)-modulated decellularized small intestinal submucosa (SIS) scaffold, and assessed the ability of this material to prevent Intervertebral disc degeneration (IVD) degeneration. Decellularized porcine SIS was squashed into particles and the biological safety and efficiency of these particles were evaluated. Next, SIS particles were seeded with rabbit NPCs, cultured for two months in vitro, decellularized again and suspended for intervertebral injection. We demonstrated that use of the decellularization protocol resulted in the removal of cellular components with maximal retention of extracellular matrix...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402320/prevalence-of-modic-changes-in-the-lumbar-vertebrae-and-their-associations-with-workload-smoking-and-weight-in-northern-china
#14
Chao Han, Ming-Jie Kuang, Jian-Xiong Ma, Xin-Long Ma
The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. The patients' weights, genders, smoking statuses, physical activity levels and specific types of MC were recorded. The associations between MCs and risk factors, such as physical work, smoking and body mass index, were also analysed...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401158/histological-identification-of-propionibacterium-acnes-in-nonpyogenic-degenerated-intervertebral-discs
#15
Ye Yuan, Zezhu Zhou, Yucheng Jiao, Changwei Li, Yuehuan Zheng, Yazhou Lin, Jiaqi Xiao, Zhe Chen, Peng Cao
Purpose. Low-virulence anaerobic bacteria, especially the Propionibacterium acnes (P. acnes), have been thought to be a new pathogeny for a series of disc diseases. However, until now, there has been no histological evidence to confirm this link. The purpose of this study was to confirm the presence of P. acnes in nonpyogenic intervertebral discs via histological observation. Method. Degenerated intervertebral discs were harvested from 76 patients with low back pain and/or sciatica but without any symptoms of discitis or spondylodiscitis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28399545/propionibacterium-acnes-incubation-in-the-discs-can-result-in-time-dependent-modic-changes-a-long-term-rabbit-model
#16
Zhi Shan, Xuyang Zhang, Shengyun Li, Tianming Yu, Junhui Liu, Fengdong Zhao
STUDY DESIGN: A case control study of animal model of Modic changes (MCs) on Rabbits. OBJECTIVE: To evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits. SUMMARY OF BACKGROUND DATA: MCs have been widely observed, and assume to be closely associated with low back pain and P. acnes, but there are few animal models showing the progression of MCs. METHODS: Ten rabbits were used for the study...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28394321/the-role-of-angiopoietin-2-in-nucleus-pulposus-cells-during-human-intervertebral-disc-degeneration
#17
Kun Wang, Wei Liu, Yu Song, Xinghuo Wu, Yukun Zhang, Shuai Li, Yong Gao, Ji Tu, Yingle Liu, Cao Yang
Although evidence shows that intervertebral disc degeneration is generally characterized by angiogenesis, the role of angiopoietin has not been investigated. This study examined the presence of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) within the native intervertebral disc (IVD) and elucidated their functions in the regulation of nucleus pulposus (NP) cells. Initial investigation of uncultured NP tissue revealed that Ang-1 and Ang-2 were expressed by native NP cells. Ang-2 expression was significantly increased in infiltrated and degenerate samples relative to normal samples...
April 10, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28392965/mechanosignaling-activation-of-tgf%C3%AE-maintains-intervertebral-disc-homeostasis
#18
Qin Bian, Lei Ma, Amit Jain, Janet L Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X Edward Guo, Paul D Sponseller, Cheryle A Séguin, Lee H Riley, Yongjun Wang, Xu Cao
Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta (TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease (DDD)...
2017: Bone Research
https://www.readbyqxmd.com/read/28392887/ros-crucial-intermediators-in-the-pathogenesis-of-intervertebral-disc-degeneration
#19
REVIEW
Chencheng Feng, Minghui Yang, Minghong Lan, Chang Liu, Yang Zhang, Bo Huang, Huan Liu, Yue Zhou
Excessive reactive oxygen species (ROS) generation in degenerative intervertebral disc (IVD) indicates the contribution of oxidative stress to IVD degeneration (IDD), giving a novel insight into the pathogenesis of IDD. ROS are crucial intermediators in the signaling network of disc cells. They regulate the matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and senescence of disc cells. Oxidative stress not only reinforces matrix degradation and inflammation, but also promotes the decrease in the number of viable and functional cells in the microenvironment of IVDs...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28387615/ectopic-expression-of-smurf2-and-acceleration-of-age-related-intervertebral-disc-degeneration-in-a-mouse-model
#20
Qiuqian Wu, Jason H Huang
OBJECTIVE Lumbar intervertebral disc degeneration, an age-related process, is a major cause of low-back pain. Although low-back pain is a very common clinical problem in the aging population, no effective treatment is available, largely owing to lack of understanding of the molecular mechanisms underlying disc degeneration. The goal of this study was to characterize how ectopic expression of Smurf2 driven by the collagen Type II alpha 1 ( Col2a1) promoter alters disc cell phenotype and associated cellular events, matrix synthesis, and gene expression during disc degeneration in mice...
April 7, 2017: Journal of Neurosurgery. Spine
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