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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/28224704/advanced-glycation-end-products-regulate-anabolic-and-catabolic-activities-via-nlrp3-inflammasome-activation-in-human-nucleus-pulposus-cells
#1
Yu Song, Yan Wang, Yukun Zhang, Wen Geng, Wei Liu, Yong Gao, Shuai Li, Kun Wang, Xinghuo Wu, Liang Kang, Cao Yang
Intervertebral disc degeneration is widely recognized as a cause of lower back pain, neurological dysfunction and other musculoskeletal disorders. The major inflammatory cytokine IL-1β is associated with intervertebral disc degeneration; however, the molecular mechanisms that drive IL-1β production in the intervertebral disc, especially in nucleus pulposus (NP) cells, are unknown. In some tissues, advanced glycation end products (AGEs), which accumulate in NP tissues and promote its degeneration, increase oxidative stress and IL-1β secretion, resulting in disorders, such as obesity, diabetes mellitus and ageing...
February 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28216287/association-between-measures-of-vertebral-endplate-morphology-and-lumbar-intervertebral-disc-degeneration
#2
Semra Duran, Mehtap Cavusoglu, Hatice Gul Hatipoglu, Deniz Sozmen Cılız, Bulent Sakman
PURPOSE: The aim of this study was to evaluate the association between vertebral endplate morphology and the degree of lumbar intervertebral disc degeneration via magnetic resonance imaging (MRI). METHODS: In total, 150 patients who met the inclusion criteria and were 20-60 years of age were retrospectively evaluated. Patients were evaluated for the presence of intervertebral disc degeneration or herniation, and the degree of degeneration was assessed at all lumbar levels...
February 16, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28215636/sirtuin-6-prevents-matrix-degradation-through-inhibition-of-the-nf-%C3%AE%C2%BAb-pathway-in-intervertebral-disc-degeneration
#3
Liang Kang, Jia Hu, Yuxiong Weng, Jie Jia, Yukun Zhang
Intervertebral disc degeneration (IDD) is marked by imbalanced metabolism of the extracellular matrix (ECM) in the nucleus pulposus (NP) of intervertebral discs. This study aimed to determine whether sirtuin 6 (SIRT6), a member of the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases, protects the NP from ECM degradation in IDD. Our study showed that expression of SIRT6 markedly decreased during IDD progression. Overexpression of wild-type SIRT6, but not a catalytically inactive mutant, prevented IL-1β-induced NP ECM degradation...
February 16, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28210985/lumbar-disc-degeneration-was-not-related-to-spine-and-hip-bone-mineral-densities-in-chinese-facet-joint-osteoarthritis-may-confound-the-association
#4
Jianjiang Pan, Xuan Lu, Ge Yang, Yongmei Han, Xiang Tong, Yue Wang
: A sample of 512 Chinese was studied and we observed that greater disc degeneration on MRI was associated with greater spine DXA BMD. Yet, this association may be confounded by facet joint osteoarthritis. BMD may not be a risk factor for lumbar disc degeneration in Chinese. PURPOSE: Evidence suggested that lumbar vertebral bone and intervertebral disc interact with each other in multiple ways. The current paper aims to determine the association between bone mineral density (BMD) and lumbar disc degeneration using a sample of Chinese...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28207788/self-complementary-adeno-associated-virus-serotype-6-mediated-knockdown-of-adamts4-induces-long-term-and-effective-enhancement-of-aggrecan-in-degenerative-human-nucleus-pulposus-cells-a-new-therapeutic-approach-for-intervertebral-disc-disorders
#5
Demissew Shenegelegn Mern, Anja Tschugg, Sebastian Hartmann, Claudius Thomé
Inhibition of intervertebral disc (IVD) degeneration, which is often accompanied by painful inflammatory and immunopathological processes, is challenging. Current IVD gene therapeutic approaches are based on adenoviral gene delivery systems, which are limited by immune reactions to their viral proteins. Their applications in IVDs near to sensitive neural structure could provoke toxicity and immunological side-effects with neurological deficits. Self-complementary adeno-associated virus (scAAV) vectors, which do not express any viral gene and are not linked with any known disease in humans, are attractive therapeutic gene delivery vectors in degenerative IVDs...
2017: PloS One
https://www.readbyqxmd.com/read/28191592/what-is-the-clinical-evidence-on-regenerative-medicine-in-intervertebral-disc-degeneration
#6
REVIEW
M Basso, L Cavagnaro, A Zanirato, S Divano, C Formica, M Formica, L Felli
PURPOSE: This review aims to explore and summarize the current clinical evidence about the use of regenerative medicine such as mesenchymal stem cells or platelet-rich plasma in intervertebral disc regeneration, in order to clarify the state of art of these novel approaches. MATERIALS AND METHODS: We performed a research of the available literature about regenerative medicine strategies aiming to prevent intervertebral disc degeneration. All preclinical trials and in vitro studies were excluded...
February 13, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28187077/comparison-of-synchrotron-radiation-based-propagation-phase-contrast-imaging-and-conventional-micro-computed-tomography-for-assessing-intervertebral-discs-and-endplates-in-a-murine-model
#7
Jianzhong Hu, Shuangfei Ni, Yong Cao, Xiaokai Wang, Shenghui Liao, Hongbin Lu
STUDY DESIGN: The synchrotron radiation based micro-CT (SRμCT) and micro-CT (μCT) were applied to comparatively assess the intervertebral disc (IVD) and endplate (EP). OBJECTIVE: To explore a new approach to evaluate the detailed structure of the IVD and EP during maturation and aging in a murine model. SUMMARY OF BACKGROUND DATA: To date, methods to observe the morphological changes in the IVD and EP from rodent have been relatively limited...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28172101/isolation-and-identification-of-stem-cells-from-degenerated-human-intervertebral-discs-and-their-migration-characteristics
#8
Shuhao Liu, Haifeng Liang, Soo-Min Lee, Zheng Li, Jian Zhang, Qinming Fei
No abstract text is available yet for this article.
February 6, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28167391/bioengineered-three-dimensional-diseased-intervertebral-disc-model-revealed-inflammatory-crosstalk
#9
Akshay Srivastava, Isma Liza Mohd Isa, Peadar Rooney, Abhay Pandit
Without an appropriate disease model, the understanding of the pathophysiology of intervertebral disc degeneration and inflammation is limited. The lack of understanding limits the potential discovery of therapeutic targets as viable treatment options. Here, we report a versatile method to develop a three-dimensional intervertebral disc (IVD) model to study the response of nucleus pulposus (NP) and annulus fibrosus (AF) cells to inflammatory (IL-1β-induced) stimulation. The cell shape regulated IVD model was engineered by modulating the crosslinking of a self-assembled collagen hydrogel...
January 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/28161709/microrna-146a-ameliorates-inflammation-via-traf6-nf-%C3%AE%C2%BAb-pathway-in-intervertebral-disc-cells
#10
Feng Lv, Yingzi Huang, Wentao Lv, Longbiao Yang, Feng Li, Jingli Fan, Jianmin Sun
BACKGROUND Intervertebral disc degeneration (IDD) has been widely recognized as a major contributor to low back pain. Accumulating evidence suggests that IDD is linked to various pro-inflammatory cytokines and metabolites. Recently, numerous studies have demonstrated that microRNAs (miRNAs) play a pivotal role in the development of most disorders, including degenerative disc diseases. Previous reports have revealed that miRNA-146a (miR-146a) could attenuate neuropathic pain in the spinal cord. The aim of this study was to investigate the role of miR-146a in the inflammatory response of IDD...
February 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28151550/canine-acute-cervical-myelopathy-hydrated-nucleus-pulposus-extrusion-or-intraspinal-discal-cysts
#11
Cristian Falzone
OBJECTIVE: To differentiate between hydrated nucleus pulposus extrusion and ventral intraspinal discal cysts in dogs. STUDY DESIGN: Prospective case series. ANIMALS: Twenty dogs with acute onset of cervical myelopathy due to hydrated nucleus pulposus extrusion or ventral intraspinal discal cysts. METHODS: Clinical and magnetic resonance (MR) imaging findings, outcome after surgical treatment, cytologic and histologic findings of compressive material were taken into account...
February 2, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28149534/iapp-modulates-cellular-autophagy-apoptosis-and-extracellular-matrix-metabolism-in-human-intervertebral-disc-cells
#12
Xinghuo Wu, Yu Song, Wei Liu, Kun Wang, Yong Gao, Shuai Li, Zhenfeng Duan, Zengwu Shao, Shuhua Yang, Cao Yang
The pathogenic process of intervertebral disc degeneration (IDD) is characterized by imbalance in the extracellular matrix (ECM) metabolism. Nucleus pulposus (NP) cells have important roles in maintaining the proper structure and tissue homeostasis of disc ECM. These cells need adequate supply of glucose and oxygen. Islet amyloid polypeptide (IAPP) exerts its biological effects by regulating glucose metabolism. The purpose of this study was to investigate the expression of IAPP in degenerated IVD tissue, and IAPP modulation of ECM metabolism in human NP cells, especially the crosstalk mechanism between apoptosis and autophagy in these cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28146016/individual-collagen-fibril-thickening-and-stiffening-of-annulus-fibrosus-in-degenerative-intervertebral-disc
#13
Ting Liang, Lin-Lin Zhang, Wei Xia, Hui-Lin Yang, Zong-Ping Luo
STUDY DESIGN: In vitro study using rat intervertebral discs (IVDs). OBJECTIVE: To explore the alteration of annulus fibrosus collagen fibrils after loading on IVD and to investigate the degeneration pathogenesis at the nanoscale. SUMMARY OF BACKGROUND DATA: Abnormal loading can lead to IVD degeneration, but the precise mechanism has been hitherto elusive, especially at the nanoscale. METHODS: A rat IVD loading model was used, which combined bending of the tail by 40° with compressive loading of 1...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28145804/coculture-with-partial-digestion-notochordal-cell-rich-nucleus-pulposus-tissue-activates-degenerative-human-nucleus-pulposus-cells
#14
Xue-Dong Bai, Xiao-Chuan Li, Jia-Hai Chen, Zi-Ming Guo, Li-Sheng Hou, De-Li Wang, Qing He, Di-Ke Ruan
Recent studies suggested that notochordal cells (NCs) and NC conditioned medium (NCCM) can stimulate cell viability and matrix production of nucleus pulposus cells (NPCs). However, the potential of notochordal cell-rich nucleus pulposus (NRNP) incorporating the native environment of the intervertebral disc has not been evaluated. The objective of this study was to develop an optimal NRNP model and test whether it can allow a significant level of NPC activation in vitro. Rabbit NRNP explants were divided into three groups according to different digestion time: digestion NRNP of 8 hours, partial digestion NRNP of 2 hours, and natural NRNP ...
February 1, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28144734/rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif
#15
Kenichiro Kita, Toshinori Sakai, Mitsunobu Abe, Yoichiro Takata, Koichi Sairyo
Lumbar intervertebral disc degeneration (LDD) is known to be associated with low back pain (LBP) and leads to degenerative lumbar disease. LDD is considered to be irreversible, and no truly effective treatment that suppresses LDD or regenerates the degenerated disc has been established thus far. Here, we report the case of a 42-year-old woman with a 10-year history of persistent LBP. Magnetic resonance imaging (MRI) demonstrated degenerative changes (Pfirrmann classification: grade IV) in the L4-5 intervertebral disc with type I and III mixed Modic changes adjacent to the disc...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28143455/the-association-of-lumbar-curve-magnitude-and-spinal-range-of-motion-in-adolescent-idiopathic-scoliosis-a-cross-sectional-study
#16
Kamil Eyvazov, Dino Samartzis, Jason Pui Yin Cheung
BACKGROUND: Spinal deformities affect the overall alignment of the spine and thus the vectors of loading on the lumbar region and intervertebral discs. Due to wedging of the disc or vertebrae of unbalanced spinal segments, alignment change may affect the range of motion (ROM) of individual spinal segments or the global spine. This is particularly important in adolescent idiopathic scoliosis (AIS) patients who may suffer from early degeneration, back stiffness and pain. Hence, this study aimed to determine the correlation between spine range of motion (ROM) and adolescent idiopathic scoliosis (AIS) curve magnitude...
January 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28143419/t2-relaxation-time-for-intervertebral-disc-degeneration-in-patients-with-upper-back-pain-initial-results-on-the-clinical-use-of-3-0-tesla-mri
#17
Raoying Xie, Linhui Ruan, Lei Chen, Kai Zhou, Jiandong Yuan, Wei Ji, Guangjian Jing, Xiaojing Huang, Qinglei Shi, Chun Chen
BACKGROUND: Magnetic resonance imaging (MRI) is a useful non-invasive tool for evaluating abnormalities of intervertebral discs. However, there are few studies which applied functional MRI techniques to investigate degenerative changes in cervical and cervicothoracic junction (CTJ) spine among adults. The aim of this study was to compare T2 relaxation time measurement evaluation with morphological grading for assessing cervical and CTJ intervertebral discs (IVD) in the patients suffering neck, shoulder, and upper back pain...
January 31, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28128000/assessment-and-rehabilitation-of-chronic-low-back-pain-in-baseball-part-ii
#18
Joseph G Wasser, Jason L Zaremski, Daniel C Herman, Heather K Vincent
Repetitive throwing and hitting motions in baseball place mechanical stresses to the lumbar spine which may cause low back pain (LBP). Pain may be due to vertebral stress reactions or insufficiency fractures, intervertebral disc degeneration or intervertebral disc herniation. Untreated chronic conditions have high potential to lead to a more significant injury such as spondylolysis. Chronic LBP increases the risk for missed playing time, early career termination and lower quality of life after retirement. Proper clinical assessment and prevention/rehabilitation of LBP in this population is thus important for performance, play time and overall long-term quality of life...
January 27, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28123635/bmsc-paracrine-activity-attenuates-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-af-cells-via-inhibiting-relative-nf-%C3%AE%C2%BAb-signaling-and-the-mitochondrial-pathway
#19
Jinquan Hu, Qiang Yan, Changgui Shi, Ye Tian, Peng Cao, Wen Yuan
We previously showed that bone mesenchymal stem cells (BMSCs) inhibit interleukin-1 beta (IL-1β) induced degenerative effects in NP cells by their paracrine activity, but the anti-inflammatory and anti-apoptotic effect of BMSC paracrine activity and the relative signaling pathway were not further investigated in annulus fibrosus (AF) cells. In this study, AF cells were exposed to IL-1β, which was applied to mimic intervertebral disc degeneration (IDD) in vitro. Indirect co-culture with BMSCs in a transwell co-culture system reduced the activity of nuclear factor-κB-p65 (NF-κB-p65) through the restoration of its inhibitor IκBa...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28116125/use-of-fgf-2-and-fgf-18-to-direct-bone-marrow-stromal-stem-cells-to-chondrogenic-and-osteogenic-lineages
#20
Cindy Shu, Susan M Smith, Christopher B Little, James Melrose
AIM: Intervertebral disc degeneration/low back pain is the number one global musculoskeletal condition in terms of disability and socioeconomic impact. MATERIALS & METHODS: Multipotent mesenchymal stem cells (MSCs) were cultured in micromass pellets ± FGF-2 or -18 up to 41 days, matrix components were immunolocalized and gene expression monitored by quantitative-reverse transcription PCR. RESULTS: Chondrogenesis occurred earlier in FGF-18 than FGF-2 cultures...
December 2016: Future Science OA
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