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Intervertebral disc degeneration

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https://www.readbyqxmd.com/read/29784673/formation-of-the-sacrum-requires-down-regulation-of-sonic-hedgehog-signaling-in-the-sacral-intervertebral-discs
#1
Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae during childhood, and their fusion to form a single bone. We show that collapse of the sacral discs in the mouse is associated with the down-regulation of sonic hedgehog (SHH) signaling in the nucleus pulposus (NP) of the disc, and many aspects of this phenotype can be reversed by experimental postnatal activation of HH signaling...
May 21, 2018: Biology Open
https://www.readbyqxmd.com/read/29784013/vegf-vascularization-pathway-in-human-intervertebral-disc-does-not-change-during-the-disc-degeneration-process
#2
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V Stoyanov
OBJECTIVE: During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth factor receptor 1, while shorter soluble forms of this receptor can inhibit vascularization. We hypothesized that membrane and soluble receptor forms might change between stages of intervertebral disc degeneration. RESULTS: Expression of soluble and membrane forms of vascular endothelial growth factor receptor 1 in human degenerated intervertebral discs and healthy bovine caudal discs was assessed by qRT-PCR and immunoblot...
May 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29779014/current-insights-on-use-of-growth-factors-as-therapy-for-intervertebral-disc-degeneration
#3
Justin C Kennon, Mohamed E Awad, Norman Chutkan, John DeVine, Sadanand Fulzele
Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration...
May 19, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/29778758/major-traits-of-the-senescent-phenotype-of-nucleus-pulposus-intervertebral-disc-cells-persist-under-the-specific-microenvironmental-conditions-of-the-tissue
#4
Anastasios Kouroumalis, Eleni Mavrogonatou, Olga D Savvidou, Panayiotis J Papagelopoulos, Harris Pratsinis, Dimitris Kletsas
Intervertebral discs (IVDs) are the joints of the spine, mainly consisting of extracellular matrix (ECM) with a low number of cells embedded therein. Low cellularity stems from nutrient deprivation due to the lack of blood supply, as well as from the hypoxic and hyperosmotic conditions prevailing in the tissue. Intervertebral disc degeneration (IDD) has been firmly connected with low back pain, a major age-related disease, whereas degenerated discs have been characterized by increased proteolytic activity and accumulation of senescent cells...
May 17, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29776411/a-study-of-the-factors-associated-with-cervical-spinal-disc-degeneration-with-a-focus-on-bone-metabolism-and-amino-acids-in-the-japanese-population-a-cross-sectional-study
#5
Kanichiro Wada, Toshihiro Tanaka, Gentaro Kumagai, Hitoshi Kudo, Toru Asari, Daisuke Chiba, Seiya Ota, Keita Kamei, On Takeda, Shigeyuki Nakaji, Yasuyuki Ishibashi
BACKGROUND: The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. METHODS: Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29772868/-significance-of-cell-autophagy-in-resorption-of-lumbar-disc-herniation
#6
REVIEW
Zhi-Jun Diao, Hong Jiang, Jin-Tao Liu
As a self-protective mechanism of cells, autophagy of cells can maintain cell stability by degrading self-aging substances, and it can be highly induced. The ability of autophagy to degraded cells will decrease with age. The resorption phenomenon after lumbar disc herniation is one of the effective mechanisms in conservative treatment of lumbar disc herniation. The degenerative lesion of intervertebral disc is one of the main reasons of lumbar disc herniation. Cell autophagy is extensive participation in the degeneration of lumbar intervertebral disc, delaying the occurrence of degenerative disease...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772854/-observation-of-early-clinical-effect-of-percutaneous-transforaminal-endoscopic-technology-in-treating-cervical-spondylotic-radiculopathy
#7
Ying-Chun Zhang, Tai-Sheng Chen, Hua Zhu
OBJECTIVE: To explore the early clinical effect and safety of percutaneous transforaminal endoscopic technology for cervical spondylotic radiculopathy. METHODS: From August 2016 to September 2017, 14 patients with cervical spondylotic radiculopathy who responded poorly to non-surgical treatment for at least 6 weeks underwent percutaneous transforaminal endoscopic discectomy via posterior approach. There were 6 males and 8 females, aging from 32 to 68 years old with an average of (40...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29770581/effect-of-static-compression-loads-on-intervertebral-disc-an-in-vivo-bent-rat-tail-model
#8
Wei Xia, Lin-Lin Zhang, Jun Mo, Wen Zhang, Hai-Tao Li, Zong-Ping Luo, Hui-Lin Yang
OBJECTIVE: To evaluate how well different magnitudes of compression-induced degenerative changes using a bent rat tail model simulated human lumbar lordosis. It has been shown that compression plays an important role in intervertebral disc degeneration (IDD). METHODS: Sprague-Dawley rats (n = 25) were instrumented with a special compressive apparatus that was used to bend the intervertebral disc between the 8th and the 10th caudal vertebral bodies using two Kirschner wires inserted percutaneously into the middle of two tail vertebrae...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29765419/low-magnitude-of-compression-enhances-biosynthesis-of-mesenchymal-stem-cells-towards-nucleus-pulposus-cells-via-the-trpv4-dependent-pathway
#9
Yibo Gan, Bing Tu, Pei Li, Jixing Ye, Chen Zhao, Lei Luo, Chengmin Zhang, Zetong Zhang, Linyong Zhu, Qiang Zhou
Mesenchymal stem cell- (MSC-) based therapy is regarded as a promising tissue engineering strategy to achieve nucleus pulposus (NP) regeneration for the treatment of intervertebral disc degeneration (IDD). However, it is still a challenge to promote the biosynthesis of MSC to meet the requirement of NP regeneration. The purpose of this study was to optimize the compressive magnitude to enhance the extracellular matrix (ECM) deposition towards discogenesis of MSCs. Thus, we constructed a 3D culture model for MSCs to bear different magnitudes of compression for 7 days (5%, 10%, and 20% at the frequency of 1...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29763470/the-influence-of-spinal-pelvic-parameters-on-the-prevalence-of-endplate-modic-changes-in-degenerative-thoracolumbar-lumbar-kyphosis-patients
#10
Weiwei Xia, Chenjun Liu, Shuo Duan, Shuai Xu, Kaifeng Wang, Zhenqi Zhu, Haiying Liu
BACKGROUND: The typical degeneration of the vertebral endplate shown in MRI imaging is Modic change. The aim of this study was to observe the distribution of the Modic changes of vertebral endplate in degenerative thoracolumbar/lumbar kyphosis (DTK/LK) patients and analyse the correlation between spinal-pelvic parameters and Modic changes. METHODS: The imaging data of 58 patients diagnosed with DTK/LK (coronal Cobb angle<10°with sagittal imbalance) in our hospital from March 2016 to May 2017 were reviewed retrospectively...
2018: PloS One
https://www.readbyqxmd.com/read/29762279/a-20-year-prospective-longitudinal-study-of-degeneration-of-the-cervical-spine-in-a-volunteer-cohort-assessed-using-mri-follow-up-of-a-cross-sectional-study
#11
Kenshi Daimon, Hirokazu Fujiwara, Yuji Nishiwaki, Eijiro Okada, Kenya Nojiri, Masahiko Watanabe, Hiroyuki Katoh, Kentaro Shimizu, Hiroko Ishihama, Nobuyuki Fujita, Takashi Tsuji, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
BACKGROUND: Few studies have addressed in detail long-term degenerative changes in the cervical spine. In this study, we evaluated the progression of degenerative changes of the cervical spine that occurred over a 20-year period in an originally healthy cohort. We also sought to clarify the relationship between the progression of cervical degenerative changes and the development of clinical symptoms. METHODS: For this prospective follow-up investigation, we recruited 193 subjects from an original cohort of 497 participants who had undergone magnetic resonance imaging (MRI) of the cervical spine between 1993 and 1996...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29761869/microrna-665-promotes-the-proliferation-and-matrix-degradation-of-nucleus-pulposus-through-targeting-gdf5-in-intervertebral-disc-degeneration
#12
Hongyu Tan, Liang Zhao, Ruipeng Song, Yilin Liu, Limin Wang
Growing evidences suggested that microRNAs (miRNAs) played important roles in the development of intervertebral disc degeneration (IDD). However, the expression level and function of miR-665 in IDD remain unknown. In this study, we showed that the expression level of miR-665 was upregulated in degenerative human NP samples. In addition, miR-665 expression level gradually increased with the exacerbation of disc degeneration grade. Moreover, miR-665 expression level was positively associated with the Pfirrmann grade...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29758454/biomechanical-investigation-on-the-influence-of-the-regional-material-degeneration-of-an-intervertebral-disc-in-a-lower-lumbar-spinal-unit-a-finite-element-study
#13
Masni-Azian, Masao Tanaka
Intervertebral disc degeneration involves changes in its material properties that affect the mechanical functions of the spinal system. However, the alteration of the biomechanics of a spinal segment through specific material degradation in a specific region is poorly understood. In this study, the influence of the constitutive material degeneration of disc tissues on the mechanics of a lower lumbar spinal unit was examined using a three-dimensional nonlinear finite element model of the L4-L5 functional spinal unit...
May 6, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29753911/aggrecan-like-biomimetic-proteoglycans-bpgs-composed-of-natural-chondroitin-sulfate-bristles-grafted-onto-poly-acrylic-acid-core-for-molecular-engineering-of-the-extracellular-matrix
#14
K Prudnikova, S E Lightfoot Vidal, S Sarkar, T Yu, R W Yucha, N Ganesh, L S Penn, L Han, C L Schauer, E J Vresilovic, M S Marcolongo
Biomimetic proteoglycans (BPGs) were designed to mimic the three-dimensional (3D) bottlebrush architecture of natural extracellular matrix (ECM) proteoglycans, such as aggrecan. BPGs were synthesized by grafting native chondroitin sulfate bristles onto a synthetic poly(acrylic acid) core to form BPGs at a molecular weight of approximately ∼1.6 MDa. The aggrecan mimics were characterized chemically, physically, and structurally, confirming the 3D bottlebrush architecture as well as a level of water uptake, which is greater than that of the natural proteoglycan, aggrecan...
May 10, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29748204/a-qualitative-and-quantitative-correlation-study-of-lumbar-intervertebral-disc-degeneration-using-glycosaminoglycan-chemical-exchange-saturation-transfer-pfirrmann-grade-and-t1-%C3%AF
#15
O Togao, A Hiwatashi, T Wada, K Yamashita, K Kikuchi, C Tokunaga, J Keupp, M Yoneyama, H Honda
BACKGROUND AND PURPOSE: Glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging allows the direct measurement and mapping of glycosaminoglycans. In this study, we aimed to evaluate the usefulness of gagCEST imaging in the quantitative assessment of intervertebral disc degeneration in a comparison with Pfirrmann grade and T1-ρ measurements. MATERIALS AND METHODS: Ninety-six lumbar intervertebral discs in 24 volunteers (36.0 ± 8.5 years of age, 21 men and 3 women) were examined with both gagCEST imaging and T1-ρ measurements...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29746847/csa-attenuates-compression-induced-nucleus-pulposus-mesenchymal-stem-cells-apoptosis-via-alleviating-mitochondrial-dysfunction-and-oxidative-stress
#16
Zhiliang Li, Songfeng Chen, Kaige Ma, Xiao Lv, Hui Lin, Binwu Hu, Ruijun He, Zengwu Shao
AIMS: This study aims to investigate the protective effects and potential mechanisms of cyclosporine A (CsA), which efficiently inhibits mitochondrial permeability transition pore (MPTP) opening, on compression-induced apoptosis of human nucleus pulposus mesenchymal stem cells (NP-MSCs). MATERIALS AND METHODS: Human NP-MSCs were subjected to various periods of 1.0 MPa compression. Cell viability was evaluated using cell counting kit-8 (CCK-8) assay. The cellular ultrastructure and ATP level were analyzed via transmission electron microscopy (TEM) and ATP detection kit respectively...
May 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29745371/microrna-194-inhibits-lipopolysaccharide-induced-inflammatory-response-in-nucleus-pulposus-cells-of-the-intervertebral-disc-by-targeting-tnf-receptor-associated-factor-6-traf6
#17
Lili Kong, Mingxiao Sun, Zhaofu Jiang, Liming Li, Bing Lu
BACKGROUND The dramatic increase of intervertebral disc degeneration (IDD) is considered to be a major cause of discogenic low back pain. The current study focused on the regulatory function of microRNA-194 (miR-194) on lipopolysaccharide (LPS)-induced inflammatory response in nucleus pulposus (NP) cells. MATERIAL AND METHODS LPS was used to treat NP cells to induce inflammatory responses. MiRNA and gene expression were detected by quantitative PCR. Proteins and protein expression levels were detected by Western blot and ELISA kit...
May 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29744650/a-novel-in-vivo-porcine-model-of-intervertebral-disc-degeneration-induced-by-cryoinjury
#18
Charles-Henri Flouzat-Lachaniette, Nicolas Jullien, Charlie Bouthors, Eric Beohou, Béatrice Laurent, Philippe Bierling, Arnaud Dubory, Hélène Rouard
PURPOSE: Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation contributes to disc degeneration and to compare this technique with standard methods. METHOD: Under general anesthesia, the lumbar discs of six pigs were exposed and randomly submitted to needle puncture of the annulus fibrosus (NeP), isolated endplate injury (EP), or cryoinjury using a 2...
May 10, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29739272/notochordal-cell-matrix-as-a-therapeutic-agent-for-intervertebral-disc-regeneration
#19
Stefan de Vries, Marina van Doeselaar, Björn Meij, Marianna A Tryfonidou, Keita Ito
Notochordal cells (NCs) reside in the core of the healthy disc and produce soluble factors that can stimulate nucleus pulposus cells (NPCs). These NC-derived factors may be applied in intervertebral disc regeneration for treatment of low back pain. However, identification of the active soluble factors is challenging. Therefore a novel approach to directly use porcine NC-rich NP matrix (NCM) is introduced. We explored porcine NCM's anabolic effects on bovine NPCs harvested from caudal discs of adolescent and adult (2-2...
May 9, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29736202/effects-of-aav2-mediated-co-transfection-of-ctgf-and-timp1-genes-on-degenerative-lumbar-intervertebral-discs-in-rhesus-monkeys-in-vivo
#20
Yong Liu, Jie Kong, Yong-Ming Xi, Tao Yu, Xiao-Lin Wu, You-Gu Hu
OBJECTIVE: This study aims to investigate the effects of co-transfection of the genes for connective tissue growth factor (CTGF) and tissue inhibitor of metalloproteinase-1 (TIMP1) mediated by adeno-associated virus 2 (AAV2) on degenerative lumbar intervertebral discs in a primate model. METHODS: Twelve 4-7 year-old rhesus monkeys weighing 4.5-7.0 kg were utilized. CTGF and TIMP1 genes carried by AAV2 were injected into the degenerative lumbar intervertebral discs...
2018: American Journal of Translational Research
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