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Muscle memory

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https://www.readbyqxmd.com/read/28445755/mapping-ryanodine-binding-sites-in-the-pore-cavity-of-ryanodine-receptors
#1
Van A Ngo, Laura L Perissinotti, Williams Miranda, S R Wayne Chen, Sergei Y Noskov
Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a family of intracellular calcium release channels essential for many cellular processes ranging from muscle contraction to learning and memory. Little is known of the atomistic details about how Ryd binds to RyRs. In this study, we used all-atom molecular dynamics simulations with both enhanced and bidirectional sampling to gain direct insights into how Ryd interacts with major residues in RyRs that were experimentally determined to be critical for its binding...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28418030/the-bmp2-nuclear-variant-nbmp2-is-expressed-in-mouse-hippocampus-and-impacts-memory
#2
Ryan D Cordner, Lindsey N Friend, Jaime L Mayo, Corinne Badgley, Andrew Wallmann, Conrad N Stallings, Peter L Young, Darla R Miles, Jeffrey G Edwards, Laura C Bridgewater
The novel nuclear protein nBMP2 is synthesized from the BMP2 gene by translational initiation at an alternative start codon. We generated a targeted mutant mouse, nBmp2NLS(tm), in which the nuclear localization signal (NLS) was inactivated to prevent nuclear translocation of nBMP2 while still allowing the normal synthesis and secretion of the BMP2 growth factor. These mice exhibit abnormal muscle function due to defective Ca(2+) transport in skeletal muscle. We hypothesized that neurological function, which also depends on intracellular Ca(2+) transport, could be affected by the loss of nBMP2...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28413654/hepatic-perivascular-epithelioid-cell-neoplasm-a-clinical-and-pathological-experience-in-diagnosis-and-treatment
#3
Wenying Chen, Yeqing Liu, Yanyan Zhuang, Juanfei Peng, Fengting Huang, Shineng Zhang
Hepatic perivascular epithelioid cell neoplasm (PEComa) is a rare type of neoplasm derived from mesenchymal tumors that is often misdiagnosed as hepatocellular carcinoma (HCC), hepatic hemangioma or other liver malignancies. The clinical and histological characteristics of PEComa have yet to be fully documented. To optimize the diagnosis and treatment of the disease, a retrospective analysis was performed to investigate the clinicopathological characteristics of 7 patients diagnosed with hepatic PEComa in the Sun Yat-Sen Memorial Hospital between January 2004 and December 2015...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28401914/a-3d-engineered-porous-conduit-for-peripheral-nerve-repair
#4
Jie Tao, Yu Hu, Shujuan Wang, Jiumeng Zhang, Xuan Liu, Zhiyuan Gou, Hao Cheng, Qianqi Liu, Qianqian Zhang, Shenglan You, Maling Gou
End-to-end neurorrhaphy is the most commonly used method for treating peripheral nerve injury. However, only 50% of patients can regain useful function after treating with neurorrhaphy. Here, we constructed a 3D-engineered porous conduit to promote the function recovery of the transected peripheral nerve after neurorrhaphy. The conduit that consisted of a gelatin cryogel was prepared by molding with 3D-printed moulds. Due to its porous structure and excellent mechanical properties, this conduit could be collapsed by the mechanical force and resumed its original shape after absorption of normal saline...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399935/prospective-clinical-study-of-rehabilitation-interventions-with-multisensory-interactive-training-in-patients-with-cerebral-infarction-study-protocol-for-a-randomised-controlled-trial
#5
Wai Leung Ambrose Lo, Yu Rong Mao, Le Li, Ai Hua Lin, Jiang Li Zhao, Ling Chen, Qiang Lin, Hai Li, Dong Feng Huang
BACKGROUND: Multisensory interactive training has an increasingly prominent role in stroke rehabilitation. Currently, there is insufficient evidence to demonstrate its efficacy on gait improvement, upper limb and lower limb functional improvement, global motor function and cognitive improvement. A recent Cochrane review confirmed that published studies on virtual reality (VR) training have the limitations of lack of powered sample size, did not evaluate the benefits over a long-term period and lacked trial quality on cognitive function...
April 11, 2017: Trials
https://www.readbyqxmd.com/read/28377708/increased-evoked-potentials-to-arousing-auditory-stimuli-during-sleep-implication-for-the-understanding-of-dream-recall
#6
Raphael Vallat, Tarek Lajnef, Jean-Baptiste Eichenlaub, Christian Berthomier, Karim Jerbi, Dominique Morlet, Perrine M Ruby
High dream recallers (HR) show a larger brain reactivity to auditory stimuli during wakefulness and sleep as compared to low dream recallers (LR) and also more intra-sleep wakefulness (ISW), but no other modification of the sleep macrostructure. To further understand the possible causal link between brain responses, ISW and dream recall, we investigated the sleep microstructure of HR and LR, and tested whether the amplitude of auditory evoked potentials (AEPs) was predictive of arousing reactions during sleep...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28376941/systematic-evaluation-of-skeletal-fractures-caused-by-induction-of-electroconvulsive-seizures-in-rat-state-a-need-for-attention-and-refinement-of-the-procedure
#7
Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia)...
April 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28371936/efficacy-of-task-specific-training-on-physical-activity-levels-of-people-with-stroke-protocol-for-a-randomized-controlled-trial
#8
Júlia Caetano Martins, Larissa Tavares Aguiar, Sylvie Nadeau, Aline Alvim Scianni, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho De Morais Faria
Background: The majority of people after stroke demonstrate mobility limitations, which may reduce their physical activity levels. Task-specific training has shown to be an effective intervention to improve mobility in individuals with stroke, however, little is known about the impact of this intervention on levels of physical activity. Objectives: The main objective will be to investigate the efficacy of a task-specific training, focused on both upper and lower limbs, in improving physical activity levels and mobility in individuals with stroke...
March 23, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28365787/synovial-cell-production-of-il-26-induces-bone-mineralization-in-spondyloarthritis
#9
Line Dam Heftdal, Thomas Andersen, Ditte Jæhger, Anders Woetmann, René Østgård, Elisabeth E Kenngott, Uta Syrbe, Joachim Sieper, Malene Hvid, Bent Deleuran, Tue W Kragstrup
Spondyloarthritis (SpA) is characterized by inflammation and new bone formation and can be treated by inhibition of the proinflammatory cytokines TNF-α and IL-17A. IL-26 is considered a proinflammatory cytokine, predominantly related to Th17 cells. In the present study, we investigate IL-26 expression in SpA patients, and examine the in vitro production of IL-26 by synovial cells and the effects of IL-26 on human osteoblasts. IL-26 was measured by ELISA in plasma and synovial fluid (SF) of 15 SpA patients and in plasma samples from 12 healthy controls...
April 2, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28350185/brain-contusion-as-the-main-risk-factor-of-memory-or-emotional-complaints-in-chronic-complicated-mild-traumatic-brain-injury
#10
Bei-Yi Su, Nai-Wen Guo, Nan-Chun Chen, Sheng-Sian Lin, Ming-Tsung Chuang, Yu-Chi Liao, Chia-Min Kuo, Cheng-Wei Lin, Willy Chou, Jinn-Rung Kuo, Shih-Yin Yen
OBJECTIVE: To investigate the risk factors for memory or emotional complaints in patients with complicated mild traumatic brain injury (mTBI). METHODS: Retrospective analysis of medical records was conducted by physicians in a teaching hospital in Southern Taiwan, and complicated mTBI had been identified by means of computed tomography. Psychological complaints, including problems with memory and emotions, were collected by structured telephone interviews, 10-15 minutes long, and were held with subjects who agreed to participate in our study...
March 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28346433/a-cytosolic-ezh1-isoform-modulates-a-prc2-ezh1-epigenetic-adaptive-response-in-postmitotic-cells
#11
Beatrice Bodega, Federica Marasca, Valeria Ranzani, Alessandro Cherubini, Francesco Della Valle, Maria Victoria Neguembor, Michel Wassef, Alessio Zippo, Chiara Lanzuolo, Massimiliano Pagani, Valerio Orlando
The evolution of chromatin-based epigenetic cell memory may be driven not only by the necessity for cells to stably maintain transcription programs, but also by the need to recognize signals and allow plastic responses to environmental stimuli. The mechanistic role of the epigenome in adult postmitotic tissues, however, remains largely unknown. In vertebrates, two variants of the Polycomb repressive complex (PRC2-Ezh2 and PRC2-Ezh1) control gene silencing via methylation of histone H3 on Lys27 (H3K27me). Here we describe a reversible mechanism that involves a novel isoform of Ezh1 (Ezh1β)...
March 27, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28341412/dorsal-muscle-attenuation-may-predict-failure-to-respond-to-interleukin-2-therapy-in-metastatic-renal-cell-carcinoma
#12
Bamidele Otemuyiwa, Brian A Derstine, Peng Zhang, Sandra L Wong, Michael S Sabel, Bruce G Redman, Stewart C Wang, Ajjai S Alva, Matthew S Davenport
RATIONALE AND OBJECTIVES: To explore whether the sarcopenia body type can help predict response to interleukin-2 (IL-2) therapy in metastatic renal cell carcinoma (RCC). MATERIALS AND METHODS: Institutional review board approval was obtained for this Health Insurance Portability and Accountability Act-compliant retrospective cohort study of 75 subjects with metastatic RCC who underwent pretreatment contrast-enhanced computed tomography within 1 year of initiating IL-2 therapy...
March 21, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28306221/construction-of-small-diameter-vascular-graft-by-shape-memory-and-self-rolling-bacterial-cellulose-membrane
#13
Ying Li, Kai Jiang, Jian Feng, Jinzhe Liu, Rong Huang, Zhaojun Chen, Junchuan Yang, Zhaohe Dai, Yong Chen, Nuoxin Wang, Wenjin Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial cellulose (BC) membranes with shape-memory properties allow the rapid preparation of artificial small-diameter blood vessels when combined with microfluidics-based patterning with multiple types of cells. Lyophilization of a wet multilayered rolled BC tube endows it with memory to recover its tubular shape after unrolling. The unrolling of the BC tube yields a flat membrane, and subsequent patterning with endothelial cells, smooth muscle cells, and fibroblast cells is carried out by microfluidics...
March 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28304092/mediation-of-cognitive-function-improvements-by-strength-gains-after-resistance-training-in-older-adults-with-mild-cognitive-impairment-outcomes-of-the-study-of-mental-and-resistance-training
#14
Yorgi Mavros, Nicola Gates, Guy C Wilson, Nidhi Jain, Jacinda Meiklejohn, Henry Brodaty, Wei Wen, Nalin Singh, Bernhard T Baune, Chao Suo, Michael K Baker, Nasim Foroughi, Yi Wang, Perminder S Sachdev, Michael Valenzuela, Maria A Fiatarone Singh
OBJECTIVES: To determine whether improvements in aerobic capacity (VO2peak ) and strength after progressive resistance training (PRT) mediate improvements in cognitive function. DESIGN: Randomized, double-blind, double-sham, controlled trial. SETTING: University research facility. PARTICIPANTS: Community-dwelling older adults (aged ≥55) with mild cognitive impairment (MCI) (N = 100). INTERVENTION: PRT and cognitive training (CT), 2 to 3 days per week for 6 months...
March 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28277941/drosophila-development-physiology-behavior-and-lifespan-are-influenced-by-altered-dietary-composition
#15
Kiel G Ormerod, Olivia K LePine, Prabhodh S Abbineni, Justin M Bridgeman, Jens R Coorssen, A Joffre Mercier, Glenn J Tattersall
Diet profoundly influences the behavior of animals across many phyla. Despite this, most laboratories using model organisms, such as Drosophila, use multiple, different, commercial or custom-made media for rearing their animals. In addition to measuring growth, fecundity and longevity, we used several behavioral and physiological assays to determine if and how altering food media influence wild-type (Canton S) Drosophila melanogaster, at larval, pupal, and adult stages. Comparing 2 commonly used commercial food media we observed several key developmental and morphological differences...
March 9, 2017: Fly
https://www.readbyqxmd.com/read/28271805/endocrinology-and-pediatric-exercise-science-2016
#16
Alon Eliakim
The Pediatric Exercise Science Year That Was section aims to highlight the most important (to the author's opinion) manuscripts that were published in 2016 in the field of endocrinology and pediatric exercise science. This year's selection includes studies showing that 1) Induction of T4 to T3 conversion by type 2 deiodinase following aerobic exercise in skeletal muscles was associated with concomitant increase in peroxisome proliferatoractivated receptor-γ coactivator-1α, and mitochondrial oxidative capacity and therefore plays an important mechanistic role in the muscle adaptation to exercise training...
February 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28262848/neuronal-function-in-male-sprague-dawley-rats-during-normal-ageing
#17
COMPARATIVE STUDY
A J Idowu, I I Olatunji-Bello, J A Olagunju
During normal ageing, there are physiological changes especially in high energy demanding tissues including the brain and skeletal muscles. Ageing may disrupt homeostasis and allow tissue vulnerability to disease. To establish an appropriate animal model which is readily available and will be useful to test therapeutic strategies during normal ageing, we applied behavioral approaches to study age-related changes in memory and motor function as a basis for neuronal function in ageing in male Sprague Dawley rats...
March 6, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/28258445/physio-somatic-symptoms-in-schizophrenia-association-with-depression-anxiety-neurocognitive-deficits-and-the-tryptophan-catabolite-pathway
#18
Buranee Kanchanatawan, Sunee Sirivichayakul, Supaksorn Thika, Kiat Ruxrungtham, André F Carvalho, Michel Geffard, George Anderson, Cristiano Noto, Rada Ivanova, Michael Maes
To investigate the frequency of physio-somatic symptoms (PS) symptoms in schizophrenia and their relation to positive, negative and affective symptoms; neurocognitive deficits and impairments in the tryptophan catabolite (TRYCAT) pathway. Eighty four patients with schizophrenia and 40 healthy controls were assessed using the 12 item Fibromyalgia and Chronic Fatigue Syndrome Rating scale (FF) and scales for negative and positive symptoms, depression and anxiety. Cognitive functioning was tested using the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
March 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28239784/effects-of-afobazole-on-postnatal-development-of-rat-offspring
#19
L I Bugaeva, T D Denisova, S A Sergeeva, Yu A Morozova, I V Kharlamov
Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior...
February 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28213398/foxo-integration-of-insulin-signaling-with-glucose-and-lipid-metabolism
#20
REVIEW
Sojin Lee, H Henry Dong
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the amino DNA-binding domain, known as 'forkhead box' domain. They mediate the inhibitory action of insulin or insulin-like growth factor on key functions involved in cell metabolism, growth, differentiation, oxidative stress, senescence, autophagy and aging. Genetic mutations in FoxO genes or abnormal expression of FoxO proteins are associated with metabolic disease, cancer or altered lifespan in humans and animals...
May 2017: Journal of Endocrinology
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