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Muscle memory

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https://www.readbyqxmd.com/read/29773001/combined-administration-of-monosodium-glutamate-and-high-sucrose-diet-accelerates-the-induction-of-type-2-diabetes-vascular-dysfunction-and-memory-impairment-in-rats
#1
Kaja Saikrishna, Ringu Kumari, Kantamaneni Chaitanya, Subhankar Biswas, Pawan G Nayak, Jayesh Mudgal, Anoop Kishore, Krishnadas Nandakumar
In this study, we aimed to develop an experimental animal model for type 2 diabetes mellitus (T2DM) using a combination of monosodium glutamate (MSG) and high sucrose diet (HSD). Young male Wistar rats (20-30 g) were injected with MSG (2 or 4 mg/g, i.p. for 4 days). These rats were also fed an HSD, while the control group was fed a starch diet (SFD) for 150 days. Parameters assessed periodically were body weight, feed intake, blood glucose level, and oral glucose tolerance test (OGTT), lipid profile, liver and kidney function tests, skeletal muscle glucose uptake, cognitive function tests, and microvascular changes using isolated rat aorta...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29765000/harnessing-bistability-for-directional-propulsion-of-soft-untethered-robots
#2
Tian Chen, Osama R Bilal, Kristina Shea, Chiara Daraio
In most macroscale robotic systems, propulsion and controls are enabled through a physical tether or complex onboard electronics and batteries. A tether simplifies the design process but limits the range of motion of the robot, while onboard controls and power supplies are heavy and complicate the design process. Here, we present a simple design principle for an untethered, soft swimming robot with preprogrammed, directional propulsion without a battery or onboard electronics. Locomotion is achieved by using actuators that harness the large displacements of bistable elements triggered by surrounding temperature changes...
May 15, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29745597/-comparative-study-on-evaluation-algorithms-for-neck-muscle-fatigue-based-on-surface-electromyography-signal
#3
Yunxiao Du, Shuyi Wang, Nyakuru Zaphlene Ndaro, Yan Zuo
The purpose of this study is to compare the differences among neck muscle fatigue evaluation algorithms and to find a more effective algorithm which can provide a human factor quantitative evaluation method for neck muscle fatigue during bending over the desk. We collected surface electromyography signal of sternocleidomastoid muscle of 15 subjects using wireless physiotherapy Bio-Radio when they bent over the desk using memory pillows for 12 minutes. Five algorithms including mean power frequency, spectral moments ratio, discrete wavelet transform, fuzzy approximation entropy and the complexity algorithms were used to calculate the corresponding muscle fatigue index...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29742721/coexistence-of-lambert-eaton-myasthenic-syndrome-and-autoimmune-encephalitis-with-anti-crmp5-cv2-and-anti-gabab-receptor-antibodies-in-small-cell-lung-cancer-a-case-report
#4
Hongfang Li, Aimei Zhang, Yanlei Hao, Hongzhi Guan, Zhanyun Lv
RATIONALE: Autoimmune encephalitis and Lambert-Eaton myasthenic syndrome are classic paraneoplastic neurological conditions common in patients with small cell lung cancer. PATIENT CONCERNS: The patient complained of tiredness, fluctuating recent memory loss, and inability to find his home. His family members reported a change in character, irritability, and paranoia. One month later, the patient had 1 grand mal seizure lasting 5 minutes. DIAGNOSIS: The patient was diagnosed with limbic encephalitis combined with Lambert-Eaton myasthenic syndrome...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741590/rate-of-muscle-contraction-is-associated-with-cognition-in-women-not-in-men
#5
Qu Tian, Yusuke Osawa, Susan M Resnick, Luigi Ferrucci, Stephanie A Studenski
Background: In older persons, lower hand grip strength is associated with poorer cognition. Little is known about how the rate of muscle contraction relates to cognition and upper extremity motor function, and sex differences are understudied. Methods: Linear regression, adjusting for age, race, education, body mass index, appendicular lean mass, and knee pain assessed sex-specific cross-sectional associations of peak torque, rate of torque development (RTD) and rate of velocity development (RVD) with cognition and upper extremity motor function...
May 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29738289/tgf%C3%AE-3-msx1-and-mmp3-as-candidates-for-nscl%C3%A2-p-in-an-indian-population
#6
Priyanka Kumari, Subodh Kumar Singh, Rajiva Raman
OBJECTIVE: To evaluate the association of transforming growth factor β3 ( TGFβ3), muscle segment homeobox 1 ( MSX1), Metalloproteinases 3 ( MMP3), and MMP9 genes as candidates for nonsyndromic cleft lip and/or palate in an Indian population. DESIGN: Case-control association study, mutational screening, and functional evaluation of obtained mutations. SETTING: Mutational screening of the developmental genes, TGFβ3 and MSX1, along with functional evaluation and association of promoter region SNPs-one each in MMP3 and MMP9...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29717811/shape-memory-alloy-sma-based-microscale-actuators-with-60-deformation-rate-and-1-6-khz-actuation-speed
#7
Hyun-Taek Lee, Min-Soo Kim, Gil-Yong Lee, Chung-Soo Kim, Sung-Hoon Ahn
Shape memory alloys (SMAs) are widely utilized as an actuation source in microscale devices, since they have a simple actuation mechanism and high-power density. However, they have limitations in terms of strain range and actuation speed. High-speed microscale SMA actuators are developed having diamond-shaped frame structures with a diameter of 25 µm. These structures allow for a large elongation range compared with bulk SMA materials, with the aid of spring-like behavior under tensile deformation. These actuators are validated in terms of their applicability as an artificial muscle in microscale by investigating their behavior under mechanical deformation and changes in thermal conditions...
May 2, 2018: Small
https://www.readbyqxmd.com/read/29709515/5-methoxyindole-2-carboxylic-acid-mica-suppresses-a%C3%AE-mediated-pathology-in-c-elegans
#8
Waqar Ahmad, Paul R Ebert
Alzheimer's disease (AD) is an age-related disease characterized by loss of memory and disrupted thinking that is associated with altered energy metabolism. Variants of an important enzyme of energy metabolism, dihydrolipoamide dehydrogenase (dld), have been genetically linked to late-onset AD. Moreover, reduced activity of DLD-containing enzyme complexes is associated with AD progression. To understand how energy metabolism influences AD progression, we exposed C. elegans expressing human Aβ peptide to the chemical inhibitor of DLD, 2-methoxyindole-5-carboxylic acid (MICA)...
April 27, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29704637/effects-of-creatine-supplementation-on-cognitive-function-of-healthy-individuals-a-systematic-review-of-randomized-controlled-trials
#9
REVIEW
Konstantinos I Avgerinos, Nikolaos Spyrou, Konstantinos I Bougioukas, Dimitrios Kapogiannis
BACKGROUND AND AIMS: Creatine is a supplement used by sportsmen to increase athletic performance by improving energy supply to muscle tissues. It is also an essential brain compound and some hypothesize that it aids cognition by improving energy supply and neuroprotection. The aim of this systematic review is to investigate the effects of oral creatine administration on cognitive function in healthy individuals. METHODS: A search of multiple electronic databases was performed for the identification of randomized clinical trials (RCTs) examining the cognitive effects of oral creatine supplementation in healthy individuals...
April 25, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29704312/self-expandable-tubular-collagen-implants
#10
Luuk R M Versteegden, Marja Ter Meer, Roger M L M Lomme, J Adam van der Vliet, Leo J Schultze Kool, Toin H van Kuppevelt, Willeke F Daamen
Collagen has been extensively used as a biomaterial, yet for tubular organ repair synthetic polymers or metals (e.g. stents) are typically used. In this study we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time and possibilities to add bioactive components to the scaffold, such as anti-coagulants...
April 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29696819/cxcl10-increases-in-human-skeletal-muscle-following-damage-but-is-not-necessary-for-muscle-regeneration
#11
Michael R Deyhle, Paul S Hafen, Jacob Parmley, Coray N Preece, Marissa Robison, Jacob R Sorensen, Blake Jackson, Dennis L Eggett, Chad R Hancock, Robert D Hyldahl
CXCL10 is a chemokine for activated and memory T cells with many important immunological functions. We recently found that CXCL10 is upregulated in human muscle following contraction-induced damage. No information is available on the role of CXCL10 in the context of muscle damage or repair. In this study, we confirm that CXCL10 is elevated in human muscle at 2 and 3 days following damage and perform cell culture and animal studies to examine the role of CXCL10 in muscle repair. CXCL10 did not impact proliferation rates of human primary myoblasts but it did promote myogenic differentiation in vitro, suggesting a possible direct impact on muscle regeneration...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29690915/clinical-study-of-children-with-cryofibrinogenemia-a-retrospective-study-from-a-single-center
#12
Hsiao-Feng Chou, Yu-Hung Wu, Che-Sheng Ho, Yu-Hsuan Kao
BACKGROUND: This study aimed to evaluate the demographic, clinical features, laboratory data, pathology and other survey in pediatric patients with cryofibrinogenemia. METHODS: A 12-year retrospective chart review identified eight pediatric patients at Mackay Memorial Hospital, Taipei, Taiwan. RESULTS: The female-to-male ratio was 3:1. The mean age at symptom onset and of diagnosis was 10.3 ± 4.6 years and 12.3 ± 4 years, respectively...
April 24, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29686822/exciting-perspectives-for-translational-myology-in-the-abstracts-of-the-2018spring-paduamuscledays-giovanni-salviati-memorial-chapter-i-foreword
#13
Ugo Carraro
Myologists working in Padua (Italy) were able to continue a half-century tradition of studies of skeletal muscles, that started with a research on fever, specifically if and how skeletal muscle contribute to it by burning bacterial toxin. Beside main publications in high-impact-factor journals by Padua myologists, I hope to convince readers (and myself) of the relevance of the editing Basic and Applied Myology (BAM), retitled from 2010 European Journal of Translational Myology (EJTM), of the institution of the Interdepartmental Research Center of Myology of the University of Padova (CIR-Myo), and of a long series of International Conferences organized in Euganei Hills and Padova, that is, the PaduaMuscleDays...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29643831/altered-intracortical-inhibition-in-chronic-traumatic-diffuse-axonal-injury
#14
Cintya Yukie Hayashi, Iuri Santana Neville, Priscila Aparecida Rodrigues, Ricardo Galhardoni, André Russowsky Brunoni, Ana Luiza Zaninotto, Vinicius Monteiro de Paula Guirado, Ana Sofia Cueva, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Background: Overactivation of NMDA-mediated excitatory processes and excess of GABA-mediated inhibition are attributed to the acute and subacute phases, respectively, after a traumatic brain injury (TBI). However, there are few studies regarding the circuitry during the chronic phase of brain injury. Objective: To evaluate the cortical excitability (CE) during the chronic phase of TBI in victims diagnosed with diffuse axonal injury (DAI). Methods: The 22 adult subjects were evaluated after a minimum of 1 year from the onset of moderate or severe TBI...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29614250/paternal-physical-exercise-demethylates-the-hippocampal-dna-of-male-pups-without-modifying-the-cognitive-and-physical-development
#15
Filipe Mega, André Luís Ferreira de Meireles, Francele Valente Piazza, Christiano Spindler, Ethiane Segabinazi, Gabriela Dos Santos Salvalaggio, Matilde Achaval, Simone Marcuzzo
Maternal exercise is known to have beneficial effects in progeny development, but the influence of paternal exercise on the offspring still unclear. Since spermatogenesis is a continuous process, the father's life experiences can reprogram epigenetic content of the sperm and somehow interfere on offspring phenotype. This study was designed to evaluate the effects of paternal physical exercise on cognitive and physical development and on hippocampal DNA methylation levels of the offspring. Adult male Wistar rats were divided into two groups: sedentary and exercised...
March 31, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29601589/influence-of-full-length-dystrophin-on-brain-volumes-in-mouse-models-of-duchenne-muscular-dystrophy
#16
Bauke Kogelman, Artem Khmelinskii, Ingrid Verhaart, Laura van Vliet, Diewertje I Bink, Annemieke Aartsma-Rus, Maaike van Putten, Louise van der Weerd
Duchenne muscular dystrophy (DMD) affects besides muscle also the brain, resulting in memory and behavioral problems. The consequences of dystrophinopathy on gross macroscopic alterations are unclear. To elucidate the effect of full-length dystrophin expression on brain morphology, we used high-resolution post-mortem MRI in mouse models that either express 0% (mdx), 100% (BL10) or a low amount of full-length dystrophin (mdx-XistΔhs). While absence or low amounts of full-length dystrophin did not significantly affect whole brain volume and skull morphology, we found differences in volume of individual brain structures...
2018: PloS One
https://www.readbyqxmd.com/read/29580209/physical-activity-and-fitness-are-associated-with-verbal-memory-quality-of-life-and-depression-among-nursing-home-residents-preliminary-data-of-a-randomized-controlled-trial
#17
Haritz Arrieta, Chloe Rezola-Pardo, Iñaki Echeverria, Miren Iturburu, Susana Maria Gil, Jose Javier Yanguas, Jon Irazusta, Ana Rodriguez-Larrad
BACKGROUND: Few studies have simultaneously examined changes in physical, cognitive and emotional performance throughout the aging process. METHODS: Baseline data from an ongoing experimental randomized study were analyzed. Physical activity, handgrip, the Senior Fitness Test, Trail Making Test A, Rey Auditory-Verbal Learning Test, Quality of Life-Alzheimer's Disease Scale (QoL-AD) and the Goldberg Depression Scale were used to assess study participants. Logistic regression models were applied...
March 27, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29569573/chronic-softening-spinal-cord-stimulation-arrays
#18
Aldo Garcia Sandoval, Ajay Pal, Asht Mishra, Sydney Sherman, Ankit Rajen Parikh, Alexandra Joshi-Imre, Gerardo Gutierrez, Adriana Carolina Duran Martinez, Jordan Adam Nathan, David Arreaga-Salas, Seyed Mahmoud Hosseini, Jason Carmel, Walter Voit
OBJECTIVE: We sought to develop a cervical spinal cord stimulator for the rat that is durable, stable, and does not perturb the underlying spinal cord. APPROACH: We created a softening spinal cord stimulation (SCS) array made from shape memory polymer (SMP)-based flexible electronics. We developed a new photolithographic process to pattern high surface area titanium nitride (TiN) electrodes onto gold (Au) interconnects. The thiol-ene acrylate polymers are stiff at room temperature and soften following implantation into the body...
March 23, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29567531/nondegradable-magnetic-poly-carbonate-urethane-microspheres-with-good-shape-memory-as-a-proposed-material-for-vascular-embolization
#19
Rongrong Liu, Qian Zhang, Qian Zhou, Ping Zhang, Honglian Dai
In this study, nondegradable poly (carbonate urethane) (PCU) and poly (carbonate urethane) incorporated variable Fe3 O4 content microspheres (PCU/Fe3 O4 ) were synthesized using pre-polymerization and suspension polymerization. Synthesis was confirmed through Fourier transform infrared spectroscopy (FTIR). The effect of Fe3 O4 incorporation was investigated on crystalline, thermal, shape memory and degradation properties by X-Ray diffraction (XRD), Differential scanning calorimetery (DSC), compression test and degradation in vitro, respectively...
February 9, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29557276/non-physical-approaches-to-counteract-age-related-functional-deterioration-applications-for-rehabilitation-and-neural-mechanisms
#20
Uros Marusic, Sidney Grosprêtre
Normal and pathological ageing are associated with several motor impairments that reduce quality of life and represent a general challenge for public healthcare systems. Consequently, over the past decades, many scientists and physiotherapists dedicated their research to the development and improvement of safe and costless methods to counteract the progressive decline of motor functions with age. The urgency of finding new and easy to implement methods is even more paramount in case of acute pathologies (e...
March 20, 2018: European Journal of Sport Science
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