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https://www.readbyqxmd.com/read/28213059/multidisciplinary-team-learning-in-the-management-of-the-morbidly-adherent-placenta-outcome-improvements-over-time
#1
Alireza A Shamshirsaz, Karin A Fox, Hadi Erfani, Steven L Clark, Bahram Salmanian, B Wycke Baker, Michael Coburn, Amir A Shamshirsaz, Zhoobin H Bateni, Jimmy Espinoza, Ahmed A Nassr, Edwina J Popek, Shiu-Ki Hui, Jun Teruya, Celestine Shauching Tung, Jeffery A Jones, Martha Rac, Gary A Dildy, Michael A Belfort
BACKGROUND: Morbidly adherent placenta (MAP) is a serious obstetric complication causing mortality and morbidity. OBJECTIVE: To evaluate whether outcomes of patients with morbidly adherent placenta improve with increasing experience within a well-established multidisciplinary team at a single referral center. STUDY DESIGN: All singleton pregnancies with pathology-confirmed MAP (including placenta accreta, increta or percreta) managed by a multidisciplinary team between January 2011 and August 2016 were included in this retrospective study...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28210250/simultaneous-activation-of-iron-and-thiol-based-sensor-regulator-systems-by-redox-active-compounds
#2
Kang-Lok Lee, Ji-Sun Yoo, Gyeong-Seok Oh, Atul K Singh, Jung-Hye Roe
Bacteria in natural habitats are exposed to myriad redox-active compounds (RACs), which include producers of reactive oxygen species (ROS) and reactive electrophile species (RES) that alkylate or oxidize thiols. RACs can induce oxidative stress in cells and activate response pathways by modulating the activity of sensitive regulators. However, the effect of a certain compound on the cell has been investigated primarily with respect to a specific regulatory pathway. Since a single compound can exert multiple chemical effects in the cell, its effect can be better understood by time-course monitoring of multiple sensitive regulatory pathways that the compound induces...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28209350/n-decyl-s-trityl-r-cysteine-a-new-chiral-selector-for-green-ligand-exchange-chromatography-applications
#3
Andrea Carotti, Federica Ianni, Emidio Camaioni, Lucia Pucciarini, Maura Marinozzi, Roccaldo Sardella, Benedetto Natalini
In search for new enantioselectivity profiles, the N-decyl-S-trityl-(R)-cysteine [C10-(R)-STC] was synthesized through a one-step procedure and then hydrophobically adsorbed onto an octadecylsilica surface to generate a stable chiral stationary phase for ligand-exchange chromatography (CLEC-CSP) applications. The CLEC analysis was carried out on underivatized amino acids, by using a Cu(II) sulphate (1.0mM) containing aqueous eluent system. Most of the analysed compounds (34 out of 45) were enantiodiscriminated by the C10-(R)-STC-based CSP, with resolution factor (RS) values up to 8...
February 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28207252/metal-metal-bridging-using-the-dppp-dye-system-electronic-configurations-within-multiple-redox-series
#4
Arijit Singha Hazari, Abhishek Mandal, Katharina Beyer, Alexa Paretzki, Wolfgang Kaim, Goutam Kumar Lahiri
Redox series [LnRu(μ-DPPP)RuLn](k), H2DPPP = 2,5-dihydro-3,6-di-2-pyridylpyrrolo(3,4-c)pyrrole-1,4-dione and L = 2,4-pentanedionato (acac(-)), 2,2'-bipyridine (bpy), and 2-phenylazopyridine (pap), have been studied by voltammetry (CV, DPV), EPR, and UV-vis-NIR spectroelectrochemistry, supported by TD-DFT calculations. Crystal structure analysis and (1)H NMR revealed oxidation states [(acac)2Ru(III)(μ-DPPP(2-))Ru(III)(acac)2] and [(bpy)2Ru(II)(μ-DPPP(2-))Ru(II)(bpy)2](2+) for the corresponding precursors, isolated as rac diastereomers...
February 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28202123/-expression-of-long-non-coding-rna-nanci-in-lung-tissues-of-neonatal-mice-with-hyperoxia-induced-lung-injury-and-its-regulatory-effect-on-nkx2-1
#5
Yuan Zhang, Huai-Ping Cheng, Tian-Ping Bao, Xiu-Gui Wang, Zhao-Fang Tian
OBJECTIVE: To investigate the expression of long non-coding RNA NANCI in lung tissues of neonatal mice with hyperoxia-induced lung injury and its regulatory effect on NKX2.1. METHODS: A total of 48 neonatal C57BL/6J mice were randomly divided into an air group and a hyperoxia group, with 24 mice in each group. Each group was further divided into 7-day, 14-day, and 21-day subgroups, with 8 mice in each subgroup. The mice in the air group were fed in the indoor environment (FiO(2)=21%) and those in the hyperoxia group were fed in a high-oxygen box (oxygen concentration: >95%)...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28196860/the-nclx-type-na-ca-2-exchanger-ncx-9-is-required-for-patterning-of-neural-circuits-in-caenorhabditis-elegans
#6
Vishal Sharma, Soumitra Roy, Israel Sekler, Damien M O'Halloran
NCLX is a Na(+)/Ca(2+) exchanger that uses energy stored in the transmembrane sodium gradient to facilitate the exchange of sodium ions for ionic calcium. Mammals have a single NCLX, which has been shown to function primarily at the mitochondrion and is an important regulator of neuronal physiology by contributing to neurotransmission and synaptic plasticity. The role of NCLX in developmental cell patterning, for example, in neural circuits, is largely unknown. Here we describe a novel role for the Caenorhabditis elegans NCLX-type protein, NCX-9, in neural circuit formation...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28191276/pathway-driven-approaches-of-interaction-between-oxidative-balance-and-genetic-polymorphism-on-metabolic-syndrome
#7
Ho-Sun Lee, Taesung Park
Despite evidences of association between basic redox biology and metabolic syndrome (MetS), few studies have evaluated indices that account for multiple oxidative effectors for MetS. Oxidative balance score (OBS) has indicated the role of oxidative stress in chronic disease pathophysiology. In this study, we evaluated OBS as an oxidative balance indicator for estimating risk of MetS with 6414 study participants. OBS is a multiple exogenous factor score for development of disease; therefore, we investigated interplay between oxidative balance and genetic variation for development of MetS focusing on biological pathways by using gene-set-enrichment analysis...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28190808/quantification-of-triacylglycerol-molecular-species-in-edible-fats-and-oils-by-gas-chromatographyflame-ionization-detector-using-correction-factors
#8
Kazuaki Yoshinaga, Junji Obi, Toshiharu Nagai, Hiroyuki Iioka, Akihiko Yoshida, Fumiaki Beppu, Naohiro Gotoh
In the present study, the resolution parameters and correction factors (CFs) of triacylglycerol (TAG) standards were estimated by gas chromatography-flame ionization detector (GC-FID) to achieve the precise quantification of the TAG composition in edible fats and oils. Forty seven TAG standards comprising capric acid, lauric acid, myristic acid, pentadecanoic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, and/or linolenic acid were analyzed, and the CFs of these TAGs were obtained against tripentadecanoyl glycerol as the internal standard...
February 10, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28189028/assessment-of-heavy-metal-pollution-spatial-distribution-and-origin-in-agricultural-soils-along-the-sin%C3%A3%C2%BA-river-basin-colombia
#9
José Marrugo-Negrete, José Pinedo-Hernández, Sergi Díez
The presence of metals in agricultural soils from anthropogenic activities such as mining and agricultural use of metals and metal-containing compounds is a potential threat for human health through the food chain. In this study, the concentration of heavy metals in 83 agricultural soils irrigated by the Sinú River, in northern Colombia, affected by mining areas upstream and inundated during seasonal floods events were determined to evaluate their sources and levels of pollution. The average concentrations of Cu, Ni, Pb, Cd, Hg and Zn were 1149, 661, 0...
February 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/28186323/the-arp2-3-inhibitory-protein-arpin-is-dispensable-for-chemotaxis
#10
Irène Dang, Joern Linkner, Jun Yan, Daniel Irimia, Jan Faix, Alexis Gautreau
Arpin is an Arp2/3 inhibitory protein, which decreases the protrusion lifetime and hence directional persistence in the migration of diverse cells. Arpin is activated by the small GTPase Rac, which controls cell protrusion, thus closing a negative feedback loop that renders the protrusion intrinsically unstable. Because of these properties, it was proposed that Arpin might play a role in directed migration, where directional persistence has to be fine-tuned. We report here, however, that Arpin depleted tumor cells and Arpin knock-out Dictyostelium amoeba display no obvious defect in chemotaxis...
February 10, 2017: Biology of the Cell
https://www.readbyqxmd.com/read/28182842/the-establishment-of-tocopherol-reference-intervals-for-hungarian-adult-population-using-validated-hplc-method
#11
Gábor Veres, László Szpisjak, Attila Bajtai, Andrea Siska, Péter Klivényi, István Ilisz, Imre Földesi, László Vécsei, Dénes Zádori
Evidence suggests that decreased α-tocopherol (the most biologically active substance in the vitamin E group) level can cause neurological symptoms, most likely ataxia. The aim of the current study was to first provide reference intervals for serum tocopherols in the adult Hungarian population with appropriate sample size recruiting healthy control subjects and neurological patients suffering from conditions without symptoms of ataxia, myopathy or cognitive deficiency. A validated HPLC method applying a diode array detector and rac-tocol as internal standard was utilized for that purpose...
February 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28181912/the-role-of-oxidative-stress-and-nadph-oxidase-in-the-pathogenesis-of-atherosclerosis
#12
Dorota Bryk, Wioletta Olejarz, Danuta Zapolska-Downar
Reactive oxygen species (ROS) play a key role in the pathogenesis of atherosclerosis. The main mechanisms which are involved are low-density lipoprotein oxidative modification, inactivation of nitric oxide and modulation of redox-sensitive signaling pathways. ROS contribute to several aspects of atherosclerosis including endothelial cell dysfunction, monocyte/macrophage recruitment and activation, stimulation of inflammation, and inducing smooth muscle cell migration and proliferation. NADPH oxidase is the main source of ROS in the vasculature...
January 28, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28177363/evaluation-of-ractopamine-hydrochloride-optaflexx-on-growth-performance-and-carcass-characteristics-of-finishing-steers-across-different-feeding-durations
#13
C J Bittner, M A Greenquist, D B Burken, A L Shreck, J C MacDonald, T J Klopfenstein, W J Platter, M T Van Koevering, N A Pyatt, G E Erickson
Two experiments were conducted to evaluate the effects of ractopamine hydrochloride (RAC) dose and duration on growth performance and carcass characteristics of finishing steers. In Exp. 1, 336 crossbred steers (initial BW of RAC feeding = 539 kg [SD 22]) were used in a 2 × 2 factorial arrangement of treatments with one factor being RAC dose (0 or 200 mg/steer daily) and the other factor being RAC duration (28 or 42 d prior to harvest). There were no RAC dose × duration interactions ( ≥ 0.08) for growth performance or carcass characteristics...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28175419/217%C3%A2-yap-is-ready-to-rac-and-rho-elucidation-of-a-novel-yap-driven-network-that-potentiates-brain-cancer-cell-dispersal-and-confers-poor-survival-in-patients
#14
Sagar R Shah, Nathaniel Tippens, JinSeok Park, Ahmed Mohyeldin, Guillermo Vela, Juan Carlos Martinez-Gutierrez, Seth S Margolis, Susanne Schmidt, Andre Levchenko, Alfredo Quinones-Hinojosa
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28173828/cancer-cells-increase-endothelial-cell-tube-formation-and-survival-by-activating-the-pi3k-akt-signalling-pathway
#15
Hao-Wei Cheng, Yi-Fang Chen, Jau-Min Wong, Chia-Wei Weng, Hsuan-Yu Chen, Sung-Liang Yu, Huei-Wen Chen, Ang Yuan, Jeremy J W Chen
BACKGROUND: Angiogenesis is a hallmark of cancer and plays a critical role in lung cancer progression, which involves interactions between cancer cells, endothelial cells and the surrounding microenvironment. However, the gene expression profiles and the changes in the biological phenotype of vascular endothelial cells after interactions with lung cancer cells remain unclear. METHODS: An indirect transwell co-culture system was used to survey the interaction between human umbilical vein endothelial cells (HUVECs) and human lung adenocarcinoma CL1-5 cells, as well as to investigate the morphological and molecular changes of HUVECs...
February 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28164413/the-botrytis-cinerea-pak-kinase-bccla4-mediates-morphogenesis-growth-and-cell-cycle-regulating-processes-downstream-of-bcrac
#16
Anna Minz-Dub, Amir Sharon
Rac proteins are involved in a variety of cellular processes. Effector proteins that interact with active Rac convey the GTPase-generated signal to downstream developmental cascades and processes. Here we report on the analysis of the main effector and signal cascade downstream of BcRac, the Rac homolog of the grey mold fungus Botrytis cinerea. Several lines of evidence highlighted the p21-activated kinase Cla4 as an important effector of Rac in fungi. Analysis of Δbccla4 strains revealed that the BcCla4 protein was sufficient to mediate all of the examined BcRac-driven processes, including hyphal growth and morphogenesis, conidia production and pathogenicity...
February 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28161523/myomaker-is-required-for-the-fusion-of-fast-twitch-myocytes-in-the-zebrafish-embryo
#17
Weibin Zhang, Sudipto Roy
During skeletal muscle development, myocytes aggregate and fuse to form multinucleated muscle fibers. Inhibition of myocyte fusion is thought to significantly derail the differentiation of functional muscle fibers. Despite the purported importance of fusion in myogenesis, in vivo studies of this process in vertebrates are rather limited. Myomaker, a multipass transmembrane protein, has been shown to be the first muscle-specific fusion protein essential for myocyte fusion in the mouse. We have generated loss-of-function alleles in zebrafish myomaker, and found that fusion of myocytes into syncytial fast-twitch muscles was significantly compromised...
February 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28160553/small-g-protein-rac-gtpases-regulate-the-maintenance-of-glioblastoma-stem-like-cells-in-vitro-and-in-vivo
#18
Yun-Ju Lai, Jui-Cheng Tsai, Ying-Ting Tseng, Meng-Shih Wu, Wen-Shan Liu, Hoi-Ian Lam, Jei-Hwa Yu, Susan E Nozell, Etty N Benveniste
Glioblastoma is the most common and aggressive malignant brain tumor in adults. The existence of glioblastoma stem cells (GSCs) or stem-like cells (stemloids) may account for its invasiveness and high recurrence. Rac proteins belong to the Rho small GTPase subfamily which regulates cell movement, proliferation, and survival. To investigate whether Rac proteins can serve as therapeutic targets for glioblastoma, especially for GSCs or stemloids, we examined the potential roles of Rac1, Rac2 and Rac3 on the properties of tumorspheres derived from glioblastoma cell lines...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28159489/atorvastatin-from-target-screening-attenuates-endothelial-cell-tube-formation-and-migration-by-regulating-urokinase-receptor-related-signaling-pathway-and-f-g-actin
#19
Li Wei, Jin-Shuen Chen, Hsin-Ting Lin, Chung-Ze Wu, Cai-Mei Zheng, Yu-Ching Chang, Li-Chien Chang, Yuh-Feng Lin
BACKGROUND: Angiogenesis and cytoskeletal transformation are common denominators of many pathological developments. The relationship between angiogenesis, urokinase plasminogen activator receptor (uPAR) signaling pathway, and cytoskeletal transformation is still unknown. In this study, a pGL3-uPAR promoter reporter system combined with Bio-Plex mRNA analysis was established for discovering uPAR modulators to analyze this interconnection. METHODS: After screening a set of clinically used drugs, atorvastatin (Ator) was found to significantly affect uPAR expression and its ideal dose, 1 μM, was determined for cell study...
January 31, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28157227/association-of-vav2-and-vav3-polymorphisms-with-cardiovascular-risk-factors
#20
Nuria Perretta-Tejedor, Javier Fernández-Mateos, Luis García-Ortiz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, Cristina Agudo-Conde, Emiliano Rodriguez-Sánchez, Ana I Morales, Francisco J López-Hernández, José M López-Novoa, Rogelio González-Sarmiento, Carlos Martínez-Salgado
Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects...
February 3, 2017: Scientific Reports
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