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https://www.readbyqxmd.com/read/28529798/crystal-structure-of-a-new-spiro-polytetra-hydro-furan-compound-with-translational-pseudosymmetry-rac-2s-2-s-5-r-2-methyl-5-1r-2r-5s-5-r-1-4-4-5-tetra-methyl-dihydro-3-h-3-8-dioxa-spiro-bi-cyclo-3-2-1-octane-2-2-furan-5-yl-hexa-hydro-2-2-bi-furan-5-2h-one
#1
Vincenzo Piccialli, Angela Tuzi, Roberto Centore
The title compound, C22H34O6, is a product of oxidation of squalene with the catalytic system RuO4(cat.)/NaIO4. The asymmetric unit contains two crystallographically independent mol-ecules of very similar geometry approximately related by the non-crystallographic translation vector c/2. As a consequence, the average diffracted intensity in the hkl layers with odd l is systematically lower than in the layers with even l. In one mol-ecule, the lactone ring and part of the adjacent tetra-hydro-furan ring are disordered over two orientations with refined occupancy ratio of 0...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28529796/crystal-structure-of-di-bromo-meth-oxy-seselin-dbms-a-photobiologically-active-pyran-ocoumarin
#2
A K Bauri, Sabine Foro, A F M M Rahman
The title compound, C15H14Br2O4 [systematic name: rac-(9S,10R)-3,9-dibromo-10-methoxy-8,8-dimethyl-9,10-dihydropyrano[2,3-h]chromen-2(8H)-one], is a pyran-ocoumarin derivative formed by the bromination of seselin, which is a naturally occurring angular pyran-ocoumarin isolated from the Indian herb Trachyspermum stictocarpum. In the mol-ecule, the benzo-pyran ring system is essentially planar, with a maximum deviation of 0.044 (2) Å for the O atom. The di-hydro-pyran ring is in a half-chair conformation and the four essentially planar atoms of this ring form a dihedral angle of 4...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28524861/an-apicobasal-gradient-of-rac-activity-determines-protrusion-form-and-position
#3
Africa Couto, Natalie Ann Mack, Lucrezia Favia, Marios Georgiou
Each cell within a polarized epithelial sheet must align and correctly position a wide range of subcellular structures, including actin-based dynamic protrusions. Using in vivo inducible transgenes that can sense or modify Rac activity, we demonstrate an apicobasal gradient of Rac activity that is required to correctly form and position distinct classes of dynamic protrusion along the apicobasal axis of the cell. We show that we can modify the Rac activity gradient in genetic mutants for specific polarity proteins, with consequent changes in protrusion form and position and additionally show, using photoactivatable Rac transgenes, that it is the level of Rac activity that determines protrusion form...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28523620/occurrence-and-fractionation-of-cr-along-the-loushan-river-affected-by-a-chromium-slag-heap-in-east-china
#4
Youyuan Chen, Bingbing Dong, Jia Xin
This study investigated the chromium (Cr) occurrence and distribution along the Loushan River adjacent to a chromium slag heap. The speciation and chemical fractionation of Cr in different environmental media were determined. The potential ecological risks for the surrounding environment were assessed on the basis of both potential ecological risk index (RI) and risk assessment code (RAC). The results show that the surface soil experienced severe Cr contamination with Cr(T) and Cr(VI) values of 3220 ± 6266 and 64 ± 94 mg/kg, respectively, even though the chromium slag heap had already been removed...
May 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28521450/atmospheric-particulate-matter2-5-promotes-the-migration-and-invasion-of-hepatocellular-carcinoma-cells
#5
Qian Zhang, Qiong Luo, Xueyu Yuan, Li Chai, Dan Li, Jianjun Liu, Zhongwei Lv
Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was to explore the response of the HCC cell lines HepG2 and HuH-7 to PM2.5 exposure. The results revealed that PM2.5 treatment promoted the migration and invasion of HCC cells, in addition to increasing protein levels of matrix metalloproteinase (MMP)-13...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28517365/enantioselective-dissipation-of-pyriproxyfen-in-soils-and-sand
#6
Hui Liu, Peng Wang, Zhiqiang Zhou, Donghui Liu
Under normal conditions, the environmental behaviors of pesticides are affected by complex environmental factors and the manner of administration together with constraints. In order to meet the actual needs, we imitated the experiment and found that the degradation rate of pyriproxyfen in soils rendered complex changes. Rac-pyriproxyfen was successfully chiral separated on an AZ-H column and the residue analysis method was in accord with the demand of pesticide analysis. The results indicated that pyriproxyfen dissipated at a faster rate in Heilongjiang soil and Hainan soil, while at a much slower speed in another three soils and sand...
May 18, 2017: Chirality
https://www.readbyqxmd.com/read/28513273/the-clinical-value-of-vav3-in-peripheral-blood-for-predicting-lymphatic-metastasis-of-gastric-cancer
#7
B Tan, Y Li, C Wang, M Tan, L Fan, Q Zhao, D Wang, N Jia
BACKGROUND: Overexpression of Vav3, a gene involved in signal transduction, promotes invasion and inhibits apoptosis in several cancers. The clinical value of the protein product of this gene, Vav3, in the peripheral blood of gastric cancer patients is unknown. We hypothesised increased serum Vav3 that related to tissue levels and lymph node metastases. In addition, we further explored its clinical value in respect of linked molecules Rac-1, MMP-7 and ICAM-1 Methods: 120 gastric cancer patients who had radical surgery were enrolled...
May 17, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28512198/novel-role-of-rac-mid1-signaling-in-medial-cerebellar-development
#8
Takashi Nakamura, Takehiko Ueyama, Yuzuru Ninoyu, Hirofumi Sakaguchi, Narantsog Choijookhuu, Yoshitaka Hishikawa, Hiroshi Kiyonari, Masaaki Kohta, Mizuho Sakahara, Ivan de Curtis, Eiji Kohmura, Yasuo Hisa, Atsu Aiba, Naoaki Saito
Rac signaling impacts a relatively large number of downstream targets; however, few studies have established an association between Rac pathways and pathological conditions. In the present study, we generated mice with double knockout of Rac1 and Rac3 (Atoh1-Cre;Rac1(flox/flox);Rac3(-/-) ) in cerebellar granule neurons (CGNs). We observed impaired tangential migration at E16.5, as well as numerous apoptotic CGNs at the deepest layer of the external granule layer (EGL) in the medial cerebellum of Atoh1-Cre;Rac1(flox/flox);Rac3(-/-) mice at P8...
May 15, 2017: Development
https://www.readbyqxmd.com/read/28508825/abcs-of-rhogtpases-indicating-potential-role-as-oncotargets
#9
REVIEW
Indira Bora, Neeta Shrivastava
RhoGTPases also known as molecular switches represent a family of GTP-binding proteins. They shuttle between "On" and "Off" states. In the "On" state, they activate plethora of molecules. These proteins perform a wide variety of functions involving cytoskeletal modeling, cell motility, migration, and mitosis. Members of this family are referred as master regulators of many cellular activities. Due to wide variety of portfolios attributed to RhoGTPases, their misbehavior leads to initiation and also progression of metastatic cancers...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28507287/integrin-beta8-itgb8-activates-vav-rac1-signaling-via-fak-in-the-acquisition-of-endometrial-epithelial-cell-receptivity-for-blastocyst-implantation
#10
Vijay Kumar, Upendra Kumar Soni, Vineet Kumar Maurya, Kiran Singh, Rajesh Kumar Jha
Integrin beta8 (ITGB8) is involved in the endometrial receptivity. The blastocyst first interacts with the luminal endometrial epithelial cells during its implantation; therefore, we have investigated the signaling of ITGB8 via FAK and VAV-RAC1 in the endometrial epithelial cells. Integrin beta8 was found elevated in epithelial cells at late-pre-receptive (day4, 1600 h) and receptive (day5, 0500 h) stages of endometrial receptivity period in the mouse. Integrins downstream molecule FAK has demonstrated an increased expression and phosphorylation (Y397) in the endometrium as well as in the isolated endometrial epithelial cells during receptive and post-receptive stages...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28504887/co2-controlled-one-pot-synthesis-of-ab-aba-block-and-statistical-terpolymers-from-%C3%AE-butyrolactone-epoxides-and-co2
#11
Sebastian Kernbichl, Marina Reiter, Friederike Adams, Sergei Vagin, Bernhard Rieger
Terpolymerizations of (rac)-β-butyrolactone (BBL), cyclohexene oxide (CHO), and carbon dioxide were realized in one-pot reactions utilizing a Lewis acid BDI(CF3)-Zn-N(SiMe3)2 (1) catalyst. The type of polymerization can be regulated and switched between ring-opening polymerization (ROP) of BBL and CHO/CO2 copolymerization by the presence of CO2 in the reaction mixture. Applying 3 bar CO2 to the three-component system leads to similar reaction rates for copolymerization and ROP and therefore to a terpolymer with a statistical composition, whereas 40 bar CO2 affords exclusive copolymerization of CHO/CO2...
May 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28498728/a-family-affair-a-ral-exocyst-centered-network-links-ras-rac-rho-signaling-to-control-cell-migration
#12
Giulia Zago, Marco Biondini, Jacques Camonis, Maria Carla Parrini
Cell migration is central to many developmental, physiologic and pathological processes, including cancer progression. The Ral GTPases (RalA and RalB) which act down-stream the Ras oncogenes, are key players in the coordination between membrane trafficking and actin polymerization. A major direct effector of Ral, the exocyst complex, works in polarized exocytosis and is at the center of multiple protein-protein interactions that support cell migration by promoting protrusion formation, front-rear polarization, and extra-cellular matrix degradation...
May 12, 2017: Small GTPases
https://www.readbyqxmd.com/read/28498140/effect-of-albumin-in-combination-with-mannitol-on-whole-blood-coagulation-in-vitro-assessed-by-thromboelastometry
#13
Kadri Lillemäe, Antti T Laine, Alexey Schramko, Tomi T Niemi
BACKGROUND: Albumin and mannitol may interfere with hemostasis, but their coinfluence is unclear. We aimed to determine the effects of albumin alone and in combination with mannitol or Ringer acetate (RAC) on hemostasis in crossover in vitro study. MATERIALS AND METHODS: From citrated fresh whole blood withdrawn from 10 volunteers, we prepared 2.5, 5, 10, 15, and 20 vol% dilutions of 4% albumin (Alb group). Each sample was thereafter diluted by 15% mannitol (Alb/Man group) or RAC (Alb/RAC group) at a ratio of 9:1...
May 11, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28493433/highly-active-and-iso-selective-catalysts-for-rop-of-cyclic-esters-using-group-2-metal-initiators
#14
Tarun Kanti Panda, Jayeeta Bhattacharjee, A Harinath, Hari P Nayek, Alok Sarkar
A series of alkali and alkaline earth (Ae) metal complexes bearing 1,2 phenylene(bis-diphenylphosphinothioic/selenoic amide) [{Ph2P(E)NH}2C6H4] (E = S (1-H2); Se (2-H2) ligands are reported. Alkali metal complexes [{Ph2P(S)N}2C6H4]Na(THF)4 (3a) [{Ph2P(Se)N}2C6H4]Na(THF)4 (3b), and [{Ph2P(Se)N}2C6H4]K(THF)5 (4b) were obtained in good yield by treating protic ligand 1-H2 or 2-H2 with corresponding metal hexamethyldisilazides [MN(SiMe3)2] (M = Na and K) at ambient temperature. The Ae metal complexes formulated as [{Ph2P(E)N}2C6H4]M(THF)3 [E = S, M = Ca (5a), Sr (6a), Ba (7a); E = Se, M = Ca (5b), Sr (6b), Ba (7b)] can be synthesized using two routes...
May 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28490229/changes-in-blood-pressure-among-patients-in-the-ontario-telehomecare-programme-an-observational-longitudinal-cohort-study
#15
Yeva Sahakyan, Lusine Abrahamyan, Nida Shahid, Alexandra Stanimirovic, Petros Pechlivanoglou, Nicholas Mitsakakis, Welson Ryan, Murray Krahn, Valeria E Rac
Background The objective of this study was to investigate the changes in blood pressure among patients enrolled in the Telehomecare programme in Ontario, Canada. Methods This observational study utilised a prospective longitudinal cohort design, including patients with heart failure and chronic obstructive pulmonary disease enrolled in the Ontario Telehomecare programme from July 2012 to July 2015. The outcome of interest was change in mean (biweekly) systolic and diastolic blood pressure levels over a six-month period...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28488466/the-removal-of-chlorinated-aliphatic-hydrocarbons-from-water-using-reactive-activated-carbon-the-influence-of-synthesis-factors-and-reaction-environments
#16
Zhang Wei, Xiao Ting, Liu Nuo, Ying Weichi
In this work, granular activated carbon composite incorporated with nanoscale zerovalent iron particles (reactive activated carbon, RAC) was synthesized by the liquid phase precipitation method and used to remove chlorinated aliphatic hydrocarbons (CAHs) from water. The influence of synthesis factors, such as base carbon types and annealing treatment temperature, and environmental factors, such as molecular structure of CAHs, common ionic species and natural organic matter, on the removal capacities of RAC for CAHs were investigated...
May 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28485481/group-4-metal-complexes-of-phenylene-salalen-ligands-in-rac-lactide-polymerization-giving-high-molecular-weight-stereoblock-poly-lactic-acid
#17
Ayellet Stopper, Tomer Rosen, Vincenzo Venditto, Israel Goldberg, Moshe Kol
Phenylene-salalens - sequential tetradentate dianionic {ONNO}-type ligands that include an ortho-phenylene group bridging between an imine and an amine internal donors bound to phenol arms having a broad variety of substitution patterns are described. Zirconium and hafnium complexes of the type [{ONNO}M(O-tert-Bu)2] were formed as single diastereomers, which, according to crystallographic structures featured the fac(around the amine)-mer(around the imine) wrapping mode. The reactivity and stereoselectivity in rac-LA polymerization were found to depend on the substitution pattern: complexes featuring small groups on the imine-side phenol and bulky groups on the amine-side phenol exhibited the favourable combination of high activity and high isoselectivity (Pm ≤ 0...
May 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28476090/identifying-the-selectivity-of-antimicrobial-peptides-to-cell-membranes-by-sum-frequency-generation-spectroscopy
#18
Thaddeus W Golbek, Johannes Franz, J Elliott Fowler, Karl F Schilke, Tobias Weidner, Joe E Baio
Cationic amphiphilic peptides have been engineered to target both Gram-positive and Gram-negative bacteria while avoiding damage to other cell types. However, the exact mechanism of how these peptides target, bind, and disrupt bacterial cell membranes is not understood. One specific peptide that has been engineered to selectively capture bacteria is WLBU2 (sequence: RRWVRRVRRWVRRVVRVVRRWVRR). It has been suggested that WLBU2 activity stems from the fact that when interacting with bacterial cell membranes the peptide assumes an α-helical structure and inserts itself into the membrane...
May 5, 2017: Biointerphases
https://www.readbyqxmd.com/read/28476001/impacts-of-rac-and-s-metolachlor-on-cyanobacterial-cell-integrity-and-release-of-microcystins-at-different-nitrogen-levels
#19
Jia Wang, Lijuan Zhang, Jiajia Fan, Yuezhong Wen
Pesticide residues and nitrogen overload (which caused cyanobacteria blooms) have been two serious environmental concerns. In particular, chiral pesticides with different structures may have various impacts on cyanobacteria. Nitrogen may affect the behavior between pesticides and cyanobacteria (e.g., increase the adverse effects of pesticides on cyanobacteria). This study evaluated the impacts of Rac- and S-metolachlor on the cell integrity and toxin release of Microcystis aeruginosa cells at different nitrogen levels...
April 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28474015/highly-thermally-stable-and-robust-enantiopure-zirconium-nnn-scorpionates-for-the-controlled-ring-opening-polymerization-of-rac-lactide
#20
Antonio Otero, Juan Fernández-Baeza, Andrés Garcés, Luis F Sánchez-Barba, Agustín Lara-Sánchez, Jaime Martínez-Ferrer, María P Carrión, Ana M Rodríguez
A series of enantiopure alkoxide and thioalkoxide zirconium derivatives [Zr(ER)3(κ(3)-R,R-fbpza)] (1-6) (E = O, R = CHMe21, CHMeEt 2, CH2SiMe33, 2,6-C6H3Me24, 4-(t)BuPh 5; E = S, R = 4-(t)BuPh 6) has been prepared for use as thermally stable and robust initiators in the ROP of rac-lactide. The compounds were prepared by alcoholysis or thioalcoholysis of the tris(amide) precursor [Zr(NMe2)3(κ(3)-R,R-fbpza)] [R,R-fbpzaH = N-p-fluorophenyl-(1R)-1-[(1R)-6,6-dimethylbicyclo[3.1.1]-2-hepten-2-yl]-2,2-bis(3,5-dimethylpyrazol-1-yl)ethylamine] with ROH and ArEH (E = O, S) in a 1 : 3 molar ratio...
May 5, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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