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https://www.readbyqxmd.com/read/29158071/frequency-of-and-factors-related-to-pro-re-nata-prn-medication-use-in-aged-care-services
#1
Jacquelina Stasinopoulos, J Simon Bell, Taliesin E Ryan-Atwood, Edwin C K Tan, Jenni Ilomäki, Tina Cooper, Leonie Robson, Janet K Sluggett
BACKGROUND: Little is known about the contribution of 'pro re nata' (PRN) medications to overall medication burden in residential aged care services (RACS). OBJECTIVES: To determine the frequency of, and factors associated with PRN medication administration in RACS. MEASUREMENTS: Details of all medications charted for regular or PRN use were extracted from medication charts for 383 residents of 6 Australian RACS. Records of medications administered over a 7 day period were also extracted...
November 7, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29156338/effect-of-laminaria-japonica-polysaccharides-on-lipids-monolayers-at-the-air-water-surface
#2
Juanjuan Yang, Changchun Hao, Runguang Sun
In this paper, we examined the effect of Laminaria japonica polysaccharides (LJP) on cationic 1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP) and anionic 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-1-glycerol] (DPPG) monolayers at the air-water interface by the pressure-area isotherms (π-A), adsorption curves (π-t) and morphology measurements with atomic force microscopy (AFM) technique. The π-A curves revealed that the isotherms shifted to larger mean molecular area with progressive addition of LJP into subphase for both DOTAP and DPPG monolayers...
November 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29145099/degradation-kinetics-study-of-1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol-plag-by-a-validated-stability-indicating-rp-hplc-method
#3
Kyeong Soo Kim, Eun Su Yang, Dong Shik Kim, Dong Wuk Kim, Chul Soon Yong, Jong Oh Kim, Sung Giu Jin, Han-Gon Choi
The chemical stability of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG), a therapeutic agent for neutropenia, was investigated using a validated stability-indicating reversed phase high-performance liquid chromatographic (RP-HPLC) method. The forced degradation of PLAG was carried out under the stress conditions of hydrolysis (alkaline, acidic and various pH buffers), oxidation, photolysis and heat. A simple, sensitive, specific, robust, precise and accurate RP-HPLC method was developed and validated for evaluating the degradation kinetics of PLAG...
November 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29144126/highly-active-carbene-potassium-complexes-for-the-ring-opening-polymerization-of-%C3%AE%C2%B5-caprolactone
#4
Mrinal Bhunia, Gonela Vijaykumar, Debashis Adhikari, Swadhin K Mandal
Herein we report the synthesis of two complexes of potassium employing strongly nucleophilic carbenes, such as cyclic "(alkyl)(amino)carbene (cAAC) and abnormal N-heterocyclic carbene (aNHC). Both complexes are dimeric in the solid state and the two potassium centers are bridged by trimethylsilylamide. In these complexes, the carbene- - -K interaction is predominantly electrostatic in character, which has been probed thoroughly by NBO and AIM analyses. Indeed, the delocalization energy of the cAAC lone pair calculated from the second-order perturbation theory was only 5...
November 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29138868/hdac-inhibitor-lmk%C3%A2-235-promotes-the-odontoblast-differentiation-of-dental-pulp-cells
#5
Zhao Liu, Ting Chen, Qianqian Han, Ming Chen, Jie You, Fuchun Fang, Ling Peng, Buling Wu
The role of dental pulp cells (DPCs) in hard dental tissue regeneration had received increasing attention because DPCs can differentiate into odontoblasts and other tissue‑specific cells. In recent years, epigenetic modifications had been identified to serve an important role in cell differentiation, and histone deacetylase (HDAC) inhibitors have been widely studied by many researchers. However, the effects of HDAC4 and HDAC5 on the differentiation of DPCs and the precise molecular mechanisms remain unclear...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29133936/the-rho-gtpase-signalling-pathway-in-urothelial-carcinoma
#6
REVIEW
Solomon L Woldu, Ryan C Hutchinson, Laura-Maria Krabbe, Oner Sanli, Vitaly Margulis
Urothelial carcinoma remains a clinical challenge: non-muscle-invasive disease has a high rate of recurrence and risk of progression, and outcomes for patients with advanced disease are poor, owing to a lack of effective systemic therapies. The Rho GTPase family of enzymes was first identified >30 years ago and contains >20 members, which are divided into eight subfamilies: Cdc42, Rac, Rho, RhoUV, RhoBTB, RhoDF, RhoH, and Rnd. Rho GTPases are molecular on-off switches, which are increasingly being understood to have a critical role in a number of cellular processes, including cell migration, cell polarity, cell adhesion, cell cycle progression, and regulation of the cytoskeleton...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133807/apelin-conformational-and-binding-equilibria-upon-micelle-interaction-primarily-depend-on-membrane-mimetic-headgroup
#7
Kyungsoo Shin, Muzaddid Sarker, Shuya K Huang, Jan K Rainey
Apelin is one of two peptide hormones that activate the apelin receptor (AR or APJ) to regulate the cardiovascular system, central nervous system, and adipoinsular axis. Here, we apply circular dichroism (CD) spectropolarimetry and nuclear magnetic resonance (NMR) spectroscopy to characterize the potential membrane binding by the two longest bioactive apelin isoforms, apelin-55 and -36, using membrane-mimetic dodecylphosphocholine (DPC), sodium dodecyl sulfate (SDS), and 1-palmitoyl-2-hydroxy-sn-glycero-3-[phospho-rac-(1-glycerol)] (LPPG) micelles...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131630/role-of-regioisomeric-bicyclo-3-3-0-octa-2-5-diene-ligands-in-rh-catalysis-synthesis-structural-analysis-theoretical-study-and-application-in-asymmetric-1-2-and-1-4-additions
#8
Tina Mühlhäuser, Alex Savin, Wolfgang Frey, Angelika Baro, Andreas J Schneider, Heinz-Günter Döteberg, Florian Bauer, Andreas Köhn, Sabine Laschat
In order to study the impact of regioisomeric diene ligands on the formation and catalytic activity of Rh complexes, a series of C2- and CS-symmetric 2,5-disubstituted bicyclo[3.3.0]octa-2,5-dienes C2-L and CS-L, respectively, were synthesized from Weiss diketone by simultaneous deprotonation/electrophilic trapping of both oxo functions, and the catalytic behavior was studied in the presence of [RhCl(C2H4)2]2. Complexes [RhCl(C2-L)]2 bearing C2-symmetric ligands catalyzed effectively the asymmetric arylation of N-tosylaldimines to (S)-diarylamines with yields and ee values up to 99%...
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29130632/dock3-related-neurodevelopmental-syndrome-biallelic-intragenic-deletion-of-dock3-in-a-boy-with-developmental-delay-and-hypotonia
#9
Aiko Iwata-Otsubo, Alyssa L Ritter, Brooke Weckselbatt, Nicole R Ryan, David Burgess, Laura K Conlin, Kosuke Izumi
Dedicator of cytokinesis (DOCK) family are evolutionary conserved guanine nucleotide exchange factors (GEFs) for the Rho GTPases, Rac, and Cdc42. DOCK3 functions as a GEF for Rac1, and plays an important role in promoting neurite and axonal growth by stimulating actin dynamics and microtubule assembly pathways in the central nervous system. Here we report a boy with developmental delay, hypotonia, and ataxia due to biallelic DOCK3 deletion. Chromosomal single nucleotide polymorphism (SNP) microarray analysis detected a 170 kb homozygous deletion including exons 6-12 of the DOCK3 gene at 3p21...
November 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29130130/heavy-metal-distribution-in-tiaoxi-river-s-sediment
#10
Binghui Zheng, Shaoyong Lu, Jinan Wu, Xiaochun Guo, Fengchang Wu, Xiangling Li, Qi He, Zhiyou Fu, Libin Xu
According to current study, seven surface sediments and three sediment cores were collected from three typical areas of Tiaoxi River, which were living area, agricultural area, and industrial area. The water quantity into the Lake Taihu from the Tiaoxi River accounted for almost one third of the total water quantity by all rivers into the Lake Taihu. To study geochemical features and pollution history of heavy metals in three typical areas of Tiaoxi River, total content and chemical fractionations of Cu, Pb, Cd, Cr, Mn, Zn, Fe, As, and Hg were analyzed for surface and core sediments using the speciation extraction procedure, proposed by the Commission of the European Communities Bureau of Reference (BCR), together with grain size and organic carbon measurements...
November 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29124783/a-key-role-for-rac-and-pak-signaling-in-neutrophil-extracellular-traps-nets-formation-defines-a-new-potential-therapeutic-target
#11
M Gavillet, K Martinod, R Renella, D D Wagner, D A Williams
NET formation in mice (NETosis) is supported by reactive oxygen species (ROS) production by NADPH oxidase and histone hypercitrullination by peptidylarginine deiminase 4 (PAD4). Rac1 and Rac2, expressed in polymorphonuclear neutrophils (PMNs), regulate the cytoskeleton, cell shape, adhesion and migration and are also essential components of the NADPH oxidase complex. We aimed to explore the role of the Rac signaling pathway including the upstream guanosine exchange factor (GEF) activator, Vav, and a downstream effector, the p21-activated kinase, Pak, on NETosis in PMNs using a previously described flow-cytometry-based assay...
November 10, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29116765/mechanism-of-the-polymerization-of-rac-lactide-by-fast-zinc-alkoxide-catalysts
#12
Daniel E Stasiw, Anna M Luke, Tomer Rosen, Aaron B League, Mukunda Mandal, Benjamin D Neisen, Christopher J Cramer, Moshe Kol, William B Tolman
The ring-opening transesterification polymerization (ROTEP) of rac-lactide (rac-LA) using L(X)Zn catalysts (L(X) = ligand having phenolate, amine, and pyridine donors with variable para substituents X on the bound phenolate donor; X = NO2, Br, t-Bu, OMe) was evaluated through kinetics experiments and density functional theory, with the aim of determining how electronic modulation of the ligand framework influences polymerization rate, selectivity, and control. After determination that zinc-ethyl precatalysts required 24 h of reaction with benzyl alcohol to convert to active alkoxide complexes, the subsequently formed species proved to be active and fairly selective, polymerizing up to 300 equiv of rac-LA in 6-10 min while yielding isotactic (Pm = 0...
November 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29115471/cardioprotective-effects-of-ulinastatin-against-isoproterenol-induced-chronic-heart-failure-through-the-pi3k%C3%A2-akt-p38-mapk-and-nf-%C3%AE%C2%BAb-pathways
#13
Lin Li, Jianhua Hao, Xian Jiang, Ping Li, Hu Sen
The purpose of the present study was to evaluate the cardioprotective effect of ulinastatin against isoproterenol‑induced chronic heart failure (CHF). Compared with the control group, treatment with ulinastatin decreased interventricular septal thickness and left ventricular posterior wall thickness, and improved the left ventricular ejection fraction, left ventricular fractional shortening and peak E and peak A ratio in the isoproterenol‑induced CHF rat. In addition, ulinastatin suppressed inflammation, oxidative stress and apoptosis in heart tissue from isoproterenol‑induced CHF rats...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115467/coenzyme-q10-promotes-osteoblast-proliferation-and-differentiation-and-protects-against-ovariectomy-induced-osteoporosis
#14
Delu Zheng, Chenli Cui, Meng Yu, Xiang Li, Lu Wang, Xinyan Chen, Yichen Lin
Coenzyme Q10 (CoQ10) is a fat‑soluble vitamin‑like substance used for the treatment of a variety of disorders, including osteoporosis. The exact mechanism underlying CoQ10‑mediated protection against osteoporosis remains to be elucidated. The present study aimed to evaluate the effect of CoQ10 on osteoblastic cell proliferation and differentiation, and therapeutic effects on a rat model of osteoporosis. Following treatment with different concentrations of CoQ10, cell proliferation and differentiation of rat bone marrow stromal cells (BMSCs), and expression of osteoblastogenic markers, were measured...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115457/identification-of-biomarkers-for-childhood-obesity-based-on-expressional-correlation-and-functional-similarity
#15
Zheng-Lun Zhu, Qiu-Meng Yang, Chen Li, Jun Chen, Min Xiang, Ming-Min Chen, Min Yan, Zheng-Gang Zhu
The aim of the current study was to identify potential biomarkers of childhood obesity, and investigate molecular mechanisms and candidate agents in order to improve therapeutic strategies for childhood obesity. The GSE9624 gene expression profile was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) in omental adipose tissues were analyzed with limma package by comparing samples from obese and normal control children. Two‑way hierarchical clustering was applied using the pheatmap package...
October 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115424/cornin-protects-sh%C3%A2-sy5y-cells-against-oxygen-and-glucose-deprivation%C3%A2-induced-autophagy-through-the-pi3k-akt-mtor-pathway
#16
Changling Ding, Jie Zhang, Baoyuan Li, Zhaoxing Ding, Wenna Cheng, Fei Gao, Ye Zhang, Yangyang Xu, Shuping Zhang
It has been reported that cornin may reduce neuronal death during cerebral ischemia; however, little is known about the molecular mechanism of the role of corninin autophagy in SH‑SY5Y neuronal cells. In the present study, oxygen‑glucose deprivation (OGD)‑treated cells were used as a cerebral ischemia model in vitro. The results demonstrated that cornin was able to reduce neuronal cell loss, increase the apoptosis regulator Bcl‑2/apoptosis regulator BAX ratio, and decrease the protein levels of caspase‑3...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29113728/expanding-the-clinical-role-of-community-pharmacy-a-qualitative-ethnographic-study-of-medication-reviews-in-ontario-canada
#17
Sarah J Patton, Fiona A Miller, Lusine Abrahamyan, Valeria E Rac
Medication reviews by community pharmacists are an increasingly common strategy to improve medication management for chronic conditions, and are part of wider efforts to make more effective use of community-based health professionals. To identify opportunities to optimize the medication review program in Ontario, Canada, we explored how providers and clients interpret and operationalize medication reviews within everyday community pharmacy practice. We conducted a qualitative ethnographic study at four pharmacies in Ontario, Canada, including non-participant observation of provider and client activities and interactions with specific attention to medication reviews, as well as brief ethnographic interviews with providers and clients, and in-depth, semi-structured interviews with providers...
November 4, 2017: Health Policy
https://www.readbyqxmd.com/read/29113186/puerarin-induces-cell-apoptosis-in-human-chondrosarcoma-cell-line-sw1353-via-inhibition-of-the-pi3k-akt-signaling-pathway
#18
Li Huang, Junqing Cao, Lan Cao, Ling Gao, Ying Yang, Li Xu
Chondrosarcoma is a malignant soft tissue sarcoma with poor prognosis. Puerarin has been demonstrated to possess anticancer properties; however, the effects of puerarin in human chondrosarcoma cells remain unknown. The present study aimed to investigate the anticancer effects of puerarin in SW1353 human chondrosarcoma cells. SW1353 cells were treated with increasing concentrations of puerarin for different durations. Cell viability was evaluated using MTT assays. Cell apoptosis rates were determined by flow cytometry...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29111771/staphylococcus-aureus-alpha-toxin-induces-actin-filament-remodeling-in-human-airway-epithelial-model-cells
#19
Sabine Ziesemer, Ina Eiffler, Alfrun Schönberg, Christian Müller, Falko Hochgräfe, Achim G Beule, Jan-Peter Hildebrandt
Exposure of cultured human airway epithelial model cells (16HBE14o-, S9) to Staphylococcus aureus alpha-toxin (hemolysin A, Hla) induces changes in cell morphology and cell layer integrity which are due to the inability of the cells to maintain stable cell-cell or focal contacts and to properly organize their actin cytoskeleton. The aim of this study was to identify Hla-activated signaling pathways involved in regulating the phosphorylation level of the actin depolymerizing factor cofilin. We used recombinant wild-type Hla (rHla) as well as a variant of Hla (rHla-H35L) that is unable to form functional transmembrane pores to treat immortalized human airway epithelial cells (16HBE14o-, S9) as well as freshly isolated human nasal tissue...
November 7, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29108059/chromium-cla-and-ractopamine-for-finishing-pigs
#20
C S Marcolla, D M Holanda, S V Ferreira, G C Rocha, N V L Serão, M S Duarte, M L T Abreu, A Saraiva
This study aimed to evaluate the effects of dietary chromium, CLA, and ractopamine on performance, carcass traits, and pork quality of finishing pigs slaughtered at 115 kg BW. Ninety-six crossbred barrows (initial BW = 70.21 ± 1.98 kg) were randomly assigned to 1 of 6 dietary treatments. There were 8 replicates per treatment (48 pens; 2 pigs/pen). A diet formulated according to the nutritional requirements was used as the control (CON). The other 5 diets were based on the CON and supplemented as follows: 0...
October 2017: Journal of Animal Science
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