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https://www.readbyqxmd.com/read/27914043/a-revisit-to-quantitative-pet-with-18-f-fdopa-of-high-specific-activity-using-a-high-resolution-condition-in-view-of-application-to-regenerative-therapy
#1
Go Akamatsu, Akihito Ohnishi, Kazuki Aita, Hiroyuki Nishida, Yasuhiko Ikari, Masahiro Sasaki, Nobuo Kohara, Michio Senda
OBJECTIVE: With the advent of regenerative/cell therapy for Parkinson's disease (PD), (18)F-FDOPA has drawn new attention as a biomarker of the therapeutic that cannot be evaluated with radiopharmaceuticals for dopamine transporter. Since most previous (18)F-FDOPA PET studies were carried out many years ago with a PET scanner of lower resolution and with (18)F-FDOPA of low specific activity synthesized from (18)F-F2, we used a newer PET/CT scanner with a high-resolution condition and (18)F-FDOPA synthesized from (18)F-F(-) to re-evaluate this technique on normal subjects and patients with PD, together with D2 receptor imaging with (11)C-raclopride (RAC)...
December 2, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27911772/c-terminal-domain-ctd-phosphatase-links-rho-gtpase-signaling-to-pol-ii-ctd-phosphorylation-in-arabidopsis-and-yeast
#2
Bo Zhang, Guohua Yang, Yu Chen, Yihong Zhao, Peng Gao, Bo Liu, Haiyang Wang, Zhi-Liang Zheng
Rho GTPases, including the Rho, Cdc42, Rac, and ROP subfamilies, act as pivotal signaling switches in various growth and developmental processes. Compared with the well-defined role of cytoskeletal organization in Rho signaling, much less is known regarding transcriptional regulation. In a mutant screen for phenotypic enhancers of transgenic Arabidopsis plants expressing a constitutively active form of ROP2 (designated CA1-1), we identified RNA polymerase II (Pol II) C-terminal domain (CTD) phosphatase-like 1 (CPL1) as a transcriptional regulator of ROP2 signaling...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27904513/relationship-between-visual-status-and-functional-status-and-the-risk-of-falls-in-women-the-rac-ost-pol-study
#3
Wojciech Rokicki, Bogna Drozdzowska, Aleksandra Czekajło, Władysław Grzeszczak, Katarzyna Wiktor, Wojciech Majewski, Wojciech Pluskiewicz
INTRODUCTION: Falls in elderly women producing fractures are a public health problem that could be largely preventable. The aim of this study was to determine the effect of visual impairment on functional status, falls and fractures in women. MATERIAL AND METHODS: We examined 623 women aged ≥ 55 years in order to assess the association between visual status and functional status and the risk of falls and fractures. Distance, near visual acuity, and depth perception were examined...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904414/near-infrared-spectroscopic-analysis-of-total-phenolic-content-and-antioxidant-activity-of-berry-fruits
#4
Jasenka Gajdoš Kljusurić, Kiril Mihalev, Ivana Bečić, Ivana Polović, Mariya Georgieva, Senka Djaković, Želimir Kurtanjek
This study evaluates the feasibility of using near-infrared (NIR) spectroscopy as a rapid and environmentally friendly technique for validation and prediction of the total phenolic content (TPC) and antioxidant activity (AOA) indices (as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, inhibition time (IT) of the Briggs-Rauscher oscillating reaction, and relative antioxidant capacity (RAC)) of berry fruit extracts. The analysed berry samples originated from Croatia (blackberries, wild blueberries, raspberries, red currants and strawberries) and Bulgaria (wild blueberries, raspberries and strawberries)...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27902969/rac1-gtp-ase-signals-wnt-beta-catenin-pathway-mediated-integrin-directed-metastasis-associated-tumor-cell-phenotypes-in-triple-negative-breast-cancers
#5
Pradip De, Jennifer H Carlson, Tyler Jepperson, Scooter Willis, Brian Leyland-Jones, Nandini Dey
The acquisition of integrin-directed metastasis-associated (ID-MA) phenotypes by Triple-Negative Breast Cancer (TNBC) cells is caused by an upregulation of the Wnt-beta-catenin pathway (WP). We reported that WP is one of the salient genetic features of TNBC. RAC-GTPases, small G-proteins which transduce signals from cell surface proteins including integrins, have been implicated in tumorigenesis and metastasis by their role in essential cellular functions like motility. The collective percentage of alteration(s) in RAC1 in ER+ve BC was lower as compared to ER-ve BC (35% vs 57%) (brca/tcga/pub2015)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901162/molecular-dynamics-simulations-and-kelvin-probe-force-microscopy-to-study-of-cholesterol-induced-electrostatic-nanodomains-in-complex-lipid-mixtures
#6
E Drolle, W F D Bennett, K Hammond, E Lyman, M Karttunen, Z Leonenko
The molecular arrangement of lipids and proteins within biomembranes and monolayers gives rise to complex film morphologies as well as regions of distinct electrical surface potential, topographical and electrostatic nanoscale domains. To probe these nanodomains in soft matter is a challenging task both experimentally and theoretically. This work addresses the effects of cholesterol, lipid composition, lipid charge, and lipid phase on the monolayer structure and the electrical surface potential distribution...
November 30, 2016: Soft Matter
https://www.readbyqxmd.com/read/27900423/contamination-fractionation-and-biological-risk-related-to-metals-in-surface-sediments-from-the-largest-deep-freshwater-lake-in-china
#7
Hua-Bing Li, Yang-Guang Gu, Rong Wang, Hui-Bin Lu
The toxicity and mobility of metals in the environment are driven by their specific chemical forms and binding states. However, heavy metal fractionation in sediments from plateau deep lakes in China is rare. This study analyzed surface sediments collected from Fuxian Lake, the largest deep freshwater lake in China; parameters examined included total metal concentrations, chemical partitioning, and biological risk assessment. The average total concentrations (mg/kg) were 7.9 for Cd, 97.6 for Pb, 102.8 for Cr, 60...
November 29, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27898862/the-influence-of-supplemental-zn-amino-acid-complex-and-ractopamine-hydrochloride-feeding-duration-on-growth-performance-and-carcass-characteristics-of-finishing-beef-cattle
#8
O N Genther-Schroeder, M E Branine, S L Hansen
Previous research indicates that finishing steer ADG and G:F increases linearly with increasing dietary Zn-amino acid complex (ZnAA) supplementation in cattle fed ractopamine hydrochloride (RAC). The objective of this study was to determine the influence of supplemental Zn-amino acid complex on growth performance and carcass characteristics of finishing steers fed RAC for 0, 28, or 42 d prior to harvest. This study was organized as 2 groups (GRP) of steers fed concurrently, for 91 (GRP 1) or 84 d (GRP 2). A total of 324 steers (463 ± 23...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896584/soil-contamination-assessment-for-pb-zn-and-cd-in-a-slag-disposal-area-using-the-integration-of-geochemical-and-microbiological-data
#9
Mariana Consiglio Kasemodel, Jacqueline Zanin Lima, Isabel Kimiko Sakamoto, Maria Bernadete Amancio Varesche, Julio Cesar Trofino, Valéria Guimarães Silvestre Rodrigues
Improper disposal of mining waste is still considered a global problem, and further details on the contamination by potentially toxic metals are required for a proper assessment. In this context, it is important to have a combined view of the chemical and biological changes in the mining dump area. Thus, the objective of this study was to evaluate the Pb, Zn and Cd contamination in a slag disposal area using the integration of geochemical and microbiological data. Analyses of soil organic matter (SOM), pH, Eh, pseudo-total concentration of metals, sequential extraction and microbial community by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) were conducted...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27895125/lineage-specific-soxr-mediated-regulation-of-an-endoribonuclease-protects-non-enteric-bacteria-from-redox-active-compounds
#10
Jisun Kim, Chulwoo Park, James A Imlay, Woojun Park
Bacteria use redox-sensitive transcription factors to coordinate responses to redox stress. The [2Fe-2S] cluster-containing transcription factor SoxR is particularly tuned to protect cells against redox-active compounds (RACs). In enteric bacteria, SoxR is paired with a second transcription factor, SoxS, that activates downstream effectors. However, SoxS is absent in non-enteric bacteria, raising questions as to how SoxR functions. Here, we first show that SoxR of Acinetobacter oleivorans displayed similar activation profiles in response to RACs as did its homolog from Escherichia coli, but controlled a different set of target genes, including sinE, which encodes an endoribonuclease...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27893588/suite-pet-ct-neuroimaging-for-the-diagnosis-of-parkinson-s-disease-statistical-parametric-mapping-analysis
#11
Ruimin Wang, Baixuan Xu, Zhe Guo, Tong Chen, Jinming Zhang, Yingmao Chen, Haiyan Zhu
OBJECTIVES: The aim of this study was to investigate the topographical distribution of dopamine transporter (DAT), dopamine D2 receptor, and glucose metabolism in Parkinson's disease (PD) using PET/computed tomography (CT) scanning and statistical parametric mapping (SPM) analysis. PARTICIPANTS AND METHODS: Seventy-four patients (58 PD patients and 16 normal controls) underwent DAT, D2 receptor, and glucose brain PET/CT scans using C-methyl-N-2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane (C-β-CFT), C-raclopride (C-RAC), and fluorine-18-fluorodeoxyglucose (F-FDG) radiotracers for the respective scans...
November 28, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27889630/1-2-3-triazolyl-ester-of-ketorolac-a-click-chemistry-based-highly-potent-pak1-blocking-cancer-killer
#12
Binh Cao Quan Nguyen, Hideaki Takahashi, Yoshihiro Uto, M D Shahinozzaman, Shinkichi Tawata, Hiroshi Maruta
An old anti-inflammatory/analgesic drug called Toradol is a racemic form of Ketorolac (50% R-form and 50% S-form) that blocks the oncogenic RAC-PAK1-COX-2 (cyclooxygenase-2) signaling, through the direct inhibition of RAC by the R-form and of COX-2 by the S-form, eventually down-regulating the production of prostaglandins. However, due to its COOH moiety which is clearly repulsive to negatively-charged phospholipid-based plasma membrane, its cell-permeability is rather poor (the IC50 against the growth of human cancer cells such as A549 is around 13 μM)...
November 20, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27885255/tfap2c-mediated-upregulation-of-tgfbr1-promotes-lung-tumorigenesis-and-epithelial-mesenchymal-transition
#13
Wanyeon Kim, EunGi Kim, Sungmin Lee, Daehoon Kim, Jahyun Chun, Kang Hyun Park, HyeSook Youn, BuHyun Youn
TFAP2C (transcription factor-activating enhancer-binding protein 2C) expression has been positively correlated with poor prognosis in patients with certain types of cancer, but the mechanisms underlying TFAP2C-mediated tumorigenesis in non-small-cell lung cancer (NSCLC) are still unknown. We previously performed a microarray analysis to identify TFAP2C regulation genes, and TGFBR1 (transforming growth factor-β receptor type 1) was found to be upregulated by TFAP2C. We observed that TFAP2C or TGFBR1 overexpression led to oncogenic properties, such as cell viability, proliferation and cell cycle progression...
November 25, 2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27884489/geochemical-speciation-bioavailability-and-source-identification-of-selected-metals-in-surface-sediments-of-the-southern-caspian-sea
#14
Kazem Darvish Bastami, Mahmoud Reza Neyestani, Marjan Esmaeilzadeh, Sarah Haghparast, Camelia Alavi, Sanaz Fathi, Shahram Nourbakhsh, Emam Ali Shirzadi, Reyhane Parhizgar
Geochemical speciation of As, Cd, Co, Cr, Cu, Ni, Pb, V and Zn were determined in the surface sediments of the southern Caspian Sea. A five-step sequential extraction technique was used to determine the chemical forms of metals. Mean concentrations (ppm) of heavy metals were (mean±S.D.) As: 9.94±1.71, Cd: 0.87±0.23, Co: 14.85±2.80, Cr: 72.29±19.48, Cu: 18.91±4.48, Ni: 32.87±5.25, Pb: 12.48±3.22, V: 86.07±20.71 and Zn: 66.85±10.11. Among the metals, Cu, As, Pb and Zn exhibited relatively higher mobility, while Cd, Co, Cr, Ni and V were found mainly in the residual fractions...
November 21, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27882919/interaction-of-the-cotranslational-hsp70-ssb-with-ribosomal-proteins-and-rrna-depends-on-its-lid-domain
#15
Andrea Gumiero, Charlotte Conz, Genís Valentín Gesé, Ying Zhang, Felix Alexander Weyer, Karine Lapouge, Julia Kappes, Ulrike von Plehwe, Géza Schermann, Edith Fitzke, Tina Wölfle, Tamás Fischer, Sabine Rospert, Irmgard Sinning
Cotranslational chaperones assist in de novo folding of nascent polypeptides in all organisms. In yeast, the heterodimeric ribosome-associated complex (RAC) forms a unique chaperone triad with the Hsp70 homologue Ssb. We report the X-ray structure of full length Ssb in the ATP-bound open conformation at 2.6 Å resolution and identify a positively charged region in the α-helical lid domain (SBDα), which is present in all members of the Ssb-subfamily of Hsp70s. Mutational analysis demonstrates that this region is strictly required for ribosome binding...
November 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27875717/comparative-study-on-the-mobility-and-speciation-of-heavy-metals-in-ashes-from-co-combustion-of-sewage-sludge-dredged-sludge-and-rice-husk
#16
Teng Wang, Yongjie Xue, Min Zhou, Yunjuan Yuan, Suyun Zhao, Gang Tan, Xian Zhou, Junjun Geng, Shaopeng Wu, Haobo Hou
The co-combustion of sludge (sewage and dredged sludge) with rice husk is expected to become a trend because of its economic and environmental benefits. However, the massive residues from the co-combustion process and the mobility of heavy metals (HMs) warrant special attention. The basic performance and environmental properties of the trace elements (Cr, Cu, Fe, Mn, Ba and Zn) from the co-combustion ashes were studied to promote the further utilization of these materials. These ashes have a shell particle shape, high specific area, high amorphous content and low crystalline phase content...
November 19, 2016: Chemosphere
https://www.readbyqxmd.com/read/27872248/rac-and-rho-compete-to-cooperate
#17
Ben Short
No abstract text is available yet for this article.
November 21, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27871818/oxidatively-generated-base-modifications-in-dna-not-only-carcinogenic-risk-factor-but-also-regulatory-mark
#18
Marco Seifermann, Bernd Epe
The generation of DNA modifications in cells is in most cases accidental and associated with detrimental consequences such as increased mutation rates and an elevated risk of malignant transformation. Accordingly, repair enzymes involved in the removal of the modifications have primarily a protective function. Among the well-established exceptions of this rule are 5-methylcytosine and uracil, which are generated in DNA enzymatically under controlled conditions and fulfill important regulatory functions in DNA as epigenetic marks and in antibody diversification, respectively...
November 18, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27871324/factors-affecting-the-delivery-of-community-pharmacist-led-medication-reviews-evidence-from-the-medscheck-annual-service-in-ontario
#19
Petros Pechlivanoglou, Lusine Abrahamyan, Linda MacKeigan, Giulia P Consiglio, Lisa Dolovich, Ping Li, Suzanne M Cadarette, Valeria E Rac, Jonghyun Shin, Murray Krahn
BACKGROUND: Medication reviews have become part of pharmacy practice across developed countries. This study aimed to identify factors affecting the likelihood of eligible Ontario seniors receiving a pharmacy-led medication review called MedsCheck annual (MCA). METHODS: We designed a cohort study using a random sample of pharmacy claims for MCA-eligible Ontario seniors using linked administrative data from April 2012 to March 2013. Guided by a conceptual framework, we constructed a generalized-estimating-equations model to estimate the effect of patient, pharmacy and community factors on the likelihood of receiving MCA...
November 21, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27863880/fractionation-of-heavy-metals-in-sediments-and-assessment-of-their-availability-risk-a-case-study-in-the-northwestern-of-persian-gulf
#20
Amirhossein Pejman, Gholamreza Nabi Bidhendi, Mojtaba Ardestani, Mohsen Saeedi, Akbar Baghvand
Sequential extraction procedure was applied to determine the chemical forms of heavy metals in sediments in order to assess their mobility and availability in the aquatic environment. The mean concentrations of Cr, Ni, Pb, Cd, Cu and Zn in exchangeable and carbonate fractions were 14.9, 30.9, 17, 0.37, 4.4 and 14.4mg/kg, respectively. Based on the sediments quality guidelines (SQGs), the adverse biological effects caused by Ni, can occur frequently across the study area. Risk assessment code (RAC) suggested that the Cd has the highest level of environmental risk compared with other studied metals...
November 15, 2016: Marine Pollution Bulletin
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