Joyce Y Buikhuisen, Patricia M Gomez Barila, Kate Cameron, Saskia J E Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J Lenos, Lisanne E Nijman, Arezo Torang, Ciro Longobardi, Joan H de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema
BACKGROUND: Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial-mesenchymal transition and stromal infiltration (Guinney et al., Nat Med 21:1350-6, 2015; Linnekamp et al., Cell Death Differ 25:616-33, 2018), whereas clinically it is characterized by lower responses to adjuvant therapy, higher incidence of metastatic spreading and hence dismal prognosis (Buikhuisen et al., Oncogenesis 9:66, 2020)...
March 3, 2023: Journal of Experimental & Clinical Cancer Research: CR