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https://www.readbyqxmd.com/read/28742208/effects-of-microrna-21-targeting-pitx2-on-proliferation-and-apoptosis-of-pituitary-tumor-cells
#1
M Cui, M Zhang, H-F Liu, J-P Wang
OBJECTIVE: Expression of pituitary homeobox 2 (PITX2) is significantly elevated in pituitary adenoma tissues, which also has lower microRNA (miR)-21 expression, indicating possible tumor-suppression role of miR-21. Bio-informatics analysis revealed targeting onto 3'-UTR of PITX2 by miR-21. This study aims to investigate the role of miR-21/PITX2 expression in proliferation and apoptosis of pituitary adenoma cells and pathogenesis. PATIENTS AND METHODS: A total of 48 pituitary adenoma samples were collected in parallel with 12 normal brain tissues and were recruited in this study...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28741261/hereditary-breast-cancer-associated-with-cowden-syndrome-related-pten-mutation-with-lhermitte-duclos-disease
#2
Fuyo Kimura, Ai Ueda, Eiichi Sato, Jiro Akimoto, Hiroshi Kaise, Kimito Yamada, Mari Hosonaga, Yuko Kawai, Saeko Teraoka, Miki Okazaki, Takashi Ishikawa
BACKGROUND: Cowden syndrome is characterized by multiple hamartomas in various tissues, including the skin, brain, breast, thyroid, mucous membrane, and gastrointestinal tract, and is reported to increase the risk of malignant disease. CASE PRESENTATION: We describe the case of a 52-year-old woman in whom a tumor was diagnosed in the left cerebellar hemisphere and treated by surgical resection. Phosphatase and tensin homolog (PTEN) mutation in exon 8 insertion was found in the brain tumor tissue and leukocytes...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28741075/brain-relaxometry-after-macrocyclic-gd-based-contrast-agent
#3
Andreas Müller, Alina Jurcoane, Burkhard Mädler, Philip Ditter, Hans Schild, Elke Hattingen
PURPOSE: To assess if ratios of T1-weighted (T1w) signal intensity (SI) and quantitative T1 relaxometry (qT1) change on serial administration of macrocyclic gadobutrol. METHODS: A total of 17 glioblastoma patients were scanned at 3.0 T magnetic resonance imaging (MRI) every 6 weeks after tumor resection with standard MRI and T1 and T2 relaxometry before and after gadobutrol administration. On co-registered images T1w SI was measured and relaxation times T1 (qT1) and quantitative T2 (qT2) were quantified in several deep grey matter nuclei as ratios relative to frontal white matter and to the pons...
July 24, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28741043/comparison-of-near-infrared-imaging-camera-systems-for-intracranial-tumor-detection
#4
Steve S Cho, Ryan Zeh, John T Pierce, Ryan Salinas, Sunil Singhal, John Y K Lee
PURPOSE: Distinguishing neoplasm from normal brain parenchyma intraoperatively is critical for the neurosurgeon. 5-Aminolevulinic acid (5-ALA) has been shown to improve gross total resection and progression-free survival but has limited availability in the USA. Near-infrared (NIR) fluorescence has advantages over visible light fluorescence with greater tissue penetration and reduced background fluorescence. In order to prepare for the increasing number of NIR fluorophores that may be used in molecular imaging trials, we chose to compare a state-of-the-art, neurosurgical microscope (System 1) to one of the commercially available NIR visualization platforms (System 2)...
July 24, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28740929/preserving-the-legacy-of-reirradiation-a-narrative-review-of-historical-publications
#5
REVIEW
Carsten Nieder, Johannes A Langendijk, Matthias Guckenberger, Anca L Grosu
PURPOSE: The purpose of this study is to illustrate the historical development of reirradiation during several decades of the 20th century, in particular between 1920 and 1960. METHODS AND MATERIALS: We chose the format of a narrative review because the historical articles are heterogeneous. No systematic extraction of baseline data, treatment details, or follow-up care was possible in many cases. RESULTS: Both hematological malignancies and solid tumors were treated with a second course of radiation therapy, and indications included local relapse, regional nodal recurrence, and second primary tumors developing in a previously treated region...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740831/the-impact-of-the-tumor-microenvironment-on-the-properties-of-glioma-stem-like-cells
#6
REVIEW
Alessandra Audia, Siobhan Conroy, Rainer Glass, Krishna P L Bhat
Glioblastoma is the most common and highly malignant primary brain tumor, and patients affected with this disease exhibit a uniformly dismal prognosis. Glioma stem-like cells (GSCs) are a subset of cells within the bulk tumor that possess self-renewal and multi-lineage differentiation properties similar to somatic stem cells. These cells also are at the apex of the cellular hierarchy and cause tumor initiation and expansion after chemo-radiation. These traits make them an attractive target for therapeutic development...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28740770/versatility-of-the-latissimus-dorsi-free-flap-during-the-treatment-of-complex-postcraniotomy-surgical-site-infections
#7
Nobutaka Yoshioka
BACKGROUND: Some intractable cases of postcraniotomy infection, which can involve compromised skin, an open frontal air sinus, and residual epidural dead space, have been reported. In such cases, reconstructing the scalp and skull is challenging. METHODS: Between 2009 and 2016, the author treated 12 patients with recalcitrant postcraniotomy surgical site infections with latissimus dorsi (LD) free flaps. The patients' ages ranged from 37 to 79 years (mean, 63.5 years), and their underlying diseases included subarachnoid hemorrhaging (n = 5), brain tumors (n = 4), and cerebral arteriovenous malformations (n = 3)...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740480/cerebrospinal-fluid-and-microdialysis-cytokines-in-severe-traumatic-brain-injury-a-scoping-systematic-review
#8
REVIEW
Frederick A Zeiler, Eric Peter Thelin, Marek Czosnyka, Peter J Hutchinson, David K Menon, Adel Helmy
OBJECTIVE: To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS: Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines. Both were conducted in severe TBI (sTBI) patients only. DATA SOURCES: Articles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28740448/evaluation-of-brain-edema-formation-defined-by-mri-after-linac-based-stereotactic-radiosurgery
#9
Maciej Harat, Andrzej Lebioda, Judyta Lasota, Roman Makarewicz
BACKGROUND: Peri-lesional edema is a serious and well-known complication of stereotactic radiosurgery (SRS). Here we evaluated edema risk after SRS and assessed its formation and resolution dynamics. PATIENTS AND METHODS: 107 patients underwent SRS for heterogeneous diagnoses: 34 (29%) with arteriovenous malformations, 38 (35%) with meningiomas, 16 (15%) with metastatic tumors, 16 (15%) with acoustic neuromas, 3 with (3%) cavernomas, and 2 (2%) each with anaplastic astrocytomas and anaplastic oligoastrocytomas...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28740365/spotlight-on-ceritinib-in-the-treatment-of-alk-nsclc-design-development-and-place-in-therapy
#10
REVIEW
Mariacarmela Santarpia, Maria Grazia Daffinà, Alessandro D'Aveni, Grazia Marabello, Alessia Liguori, Elisa Giovannetti, Niki Karachaliou, Maria Gonzalez Cao, Rafael Rosell, Giuseppe Altavilla
The identification of echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) fusion gene in non-small cell lung cancer (NSCLC) has radically changed the treatment of a subset of patients harboring this oncogenic driver. Crizotinib was the first ALK tyrosine kinase inhibitor to receive fast approval and is currently indicated as the first-line therapy for advanced, ALK-positive NSCLC patients. However, despite crizotinib's efficacy, patients almost invariably progress, with the central nervous system being one of the most common sites of relapse...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28739710/discrepancy-in-programmed-cell-death-ligand-1-between-primary-and-metastatic-non-small-cell-lung-cancer
#11
Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Masakazu Katsura, Nobutaka Mukae, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara
AIM: To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Twenty-one NSCLC patients who underwent surgery or biopsy for paired primary and metastatic lesions at our Institution from 2005 to 2016 were analyzed. Lesions with the PD-L1 expression being ≥5% were considered PD-L1-positive...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739696/differences-in-extracellular-matrix-composition-and-its-role-in-invasion-in-primary-and-secondary-intracerebral-malignancies
#12
József Virga, Csaba Dávid Szemcsák, Judit Reményi-Puskár, Judit Tóth, Tibor Hortobágyi, Éva Csősz, Gábor Zahuczky, László Szivos, Lászlo Bognár, Almos Klekner
BACKGROUND/AIM: The most common malignant primary brain tumor is glioblastoma which infiltrates the peritumoral brain, while secondary brain metastases are well demarcated malignancies. Previous research has proved the pivotal role of the changes in the extracellular matrix (ECM) in cancer cell invasion. MATERIALS AND METHODS: The mRNA expression of 40 ECM molecules was determined using qRT-PCR in 54 fresh-frozen glioblastoma and brain metastasis samples. Seventy-two samples were used to determine the levels of 20 ECM proteins...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739695/synergistic-effects-of-arsenite-on-radiosensitization-of-glioblastoma-cells
#13
Yasuharu Ninomiya, Dong Yu, Emiko Sekine-Suzuki, Tetsuo Nakajima
BACKGROUND/AIM: Glioblastoma is a frequent type of brain tumor and is radioresistant. Arsenite, which crosses the blood-brain barrier, shows synergistic effects with radiation in vitro and in vivo. The mechanism remains unclear. MATERIALS AND METHODS: As synergistic radiosensitization has been reported in p53-deficient cancer cells, radiosensitization was evaluated using the glioblastoma cell line, U87MG-E6, which harbors inactivated p53, in comparison with the cell line, HCT116 p53 (-/-)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739680/bdnf-an-oncogene-or-tumor-suppressor
#14
REVIEW
Daniel P Radin, Parth Patel
Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development and differentiation. It has also been shown to protect several neuronal cell types from an array of cytotoxic stressors after activation by its conjugate ligand brain-derived neurotrophic factor (BDNF)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739514/inhibition-of-blood-brain-barrier-efflux-transporters-promotes-seizure-in-pregnant-rats-role-of-circulating-factors
#15
Abbie C Johnson, Erica S Hammer, Sophie Sakkaki, Sarah M Tremble, Gregory L Holmes, Marilyn J Cipolla
Seizure-provoking factors circulate late in gestation during normal pregnancy, but do not readily gain access to the brain due to the protective nature of the blood-brain barrier. In particular, efflux transporters are powerful ATP-driven pumps that actively prevent unwanted compounds from entering the brain. We hypothesized that acute inhibition of efflux transporters at the blood-brain barrier would result in spontaneous seizures in pregnant rats. We further hypothesized that the blood-brain barrier protects the maternal brain from seizure by increasing expression and/or activity of p-glycoprotein (P-gp), a major efflux transporter...
July 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28739315/combination-therapy-of-radiotherapy-and-anti-pd-1-pd-l1-treatment-in-non-small-cell-lung-cancer-a-mini-review
#16
REVIEW
Shinkichi Takamori, Gouji Toyokawa, Kazuki Takada, Fumihiro Shoji, Tatsuro Okamoto, Yoshihiko Maehara
Immune checkpoint inhibitors against programmed cell death-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) are a standard pharmacologic therapy for patients with non-small-cell lung cancer (NSCLC). Substantial data have accumulated in recent years showing that radiotherapy combined with immunotherapy is more effective than monotherapy alone. Preclinical studies have shown that PD-L1 expression is upregulated on tumor cells after radiotherapy, resulting in the synergistically enhanced antitumor effect of irradiation and PD-L1 blockade...
July 6, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28738862/impact-of-ischemic-preconditioning-on-surgical-treatment-of-brain-tumors-a-single-center-randomized-double-blind-controlled-trial
#17
Arthur H A Sales, Melanie Barz, Stefanie Bette, Benedikt Wiestler, Yu-Mi Ryang, Bernhard Meyer, Martin Bretschneider, Florian Ringel, Jens Gempt
BACKGROUND: Postoperative ischemia is a frequent phenomenon in patients with brain tumors and is associated with postoperative neurological deficits and impaired overall survival. Particularly in the field of cardiac and vascular surgery, the application of a brief ischemic stimulus not only in the target organ but also in remote tissues can prevent subsequent ischemic damage. We hypothesized that remote ischemic preconditioning (rIPC) in patients with brain tumors undergoing elective surgical resection reduces the incidence of postoperative ischemic tissue damage and its consequences...
July 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28738820/omega-3-polyunsaturated-fatty-acid-supplementation-attenuates-microglial-induced-inflammation-by-inhibiting-the-hmgb1-tlr4-nf-%C3%AE%C2%BAb-pathway-following-experimental-traumatic-brain-injury
#18
Xiangrong Chen, Shukai Wu, Chunnuan Chen, Baoyuan Xie, Zhongning Fang, Weipeng Hu, Junyan Chen, Huangde Fu, Hefan He
BACKGROUND: Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs) to activate downstream signaling pathways, such as the nuclear factor (NF)-κB signaling pathway, leading to a cascade amplification of inflammatory responses, which are related to neuronal damage after TBI...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28738706/relationship-between-premature-brain-injury-and-multiple-biomarkers-in-cord-blood-and-amniotic-fluid
#19
Hongyan Lu, Weiling Huang, Xiaoqing Chen, Qiuxia Wang, Qiang Zhang, Ming Chang
PURPOSE: To investigate the relationship between premature brain injury and multiple biomarkers in cord blood and amniotic fluid, identify potential biomarkers for early monitoring of premature brain injury. METHODS: 130 cases of singleton premature infants with gestational age less than 34 weeks were evaluated. Based on brain imaging examination, all cases were divided into brain injury group and no brain injury group. Eleven biomarkers in cord blood and amniotic fluid were measured...
July 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28738538/diosmin-improved-cognitive-deficit-and-amplified-brain-electrical-activity-in-the-rat-model-of-traumatic-brain-injury
#20
Mohammad Ali Mirshekar, Hamed Fanaei, Fereshteh Keikhaei, Fatemeh Sargolzaee Javan
OBJECTIVE: Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities in humans. Clinically, it is essential to limit the progress of cognitive impairment after TBI. It is reported that diosmin has a neuroprotective effect that can limit the progress of the impairment. The aim of this study was to evaluate the effects of diosmin on neurological score, memory, tumor necrosis factor-α (TNF-α) level and long-term potentiation in hippocampal dentate gyrus after the injury...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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