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https://www.readbyqxmd.com/read/29781380/finally-a-regimen-to-extend-human-life-expectancy
#1
James Larrick, Andrew R Mendelsohn
The US has the most expensive healthcare system worldwide. Yet measures of healthspan and life expectancy are well below the major industrialized nations. With the US population aged 65 and older projected to double by mid-century a healthcare crisis is looming. Within this context huge interest and investment has emerged in technologies and drugs to address aging with an expected benefit to healthspan. The thesis being that such basic interventions will reduce morbidity caused by many chronic diseases where biological age itself is the major risk factor...
May 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29780844/outcomes-and-return-to-sport-after-ulnar-collateral-ligament-reconstruction-in-adolescent-baseball-players
#2
Michael Saper, Joseph Shung, Stephanie Pearce, Viviana Bompadre, James R Andrews
Background: The number of ulnar collateral ligament (UCL) reconstructions in adolescent athletes has increased over the past 2 decades. Clinical results in this population have not been well studied. Purpose/Hypothesis: The purpose of this study was to evaluate the outcomes and return to sport after UCL reconstruction in a large group of adolescent baseball players. We hypothesized that excellent clinical outcomes and high rates of return to sport would be observed in this population at a minimum 2-year follow-up...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29780691/understanding-d-ribose-and-mitochondrial-function
#3
Diane E Mahoney, John B Hiebert, Amanda Thimmesch, John T Pierce, James L Vacek, Richard L Clancy, Andrew J Sauer, Janet D Pierce
Mitochondria are important organelles referred to as cellular powerhouses for their unique properties of cellular energy production. With many pathologic conditions and aging, mitochondrial function declines, and there is a reduction in the production of adenosine triphosphate. The energy carrying molecule generated by cellular respiration and by pentose phosphate pathway, an alternative pathway of glucose metabolism. D-ribose is a naturally occurring monosaccharide found in the cells and particularly in the mitochondria is essential in energy production...
2018: Advances in bioscience and clinical medicine
https://www.readbyqxmd.com/read/29780162/dietary-antioxidant-intake-and-the-risk-of-developing-barrett-s-oesophagus-and-oesophageal-adenocarcinoma
#4
James H-E Kang, Robert Luben, Leo Alexandre, Andrew R Hart
BACKGROUND: We investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants, which have anti-carcinogenic properties, and development of Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). METHODS: A total of 24,068 well individuals completed 7-DFDs and donated blood. Vitamins C and E, carotenes, zinc and selenium intakes, and plasma vitamin C were measured. Participants were monitored for 15 years for BO and OAC...
May 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29779895/identification-and-single-cell-functional-characterization-of-an-endodermally-biased-pluripotent-substate-in-human-embryonic-stem-cells
#5
Thomas F Allison, Andrew J H Smith, Konstantinos Anastassiadis, Jackie Sloane-Stanley, Veronica Biga, Dylan Stavish, James Hackland, Shan Sabri, Justin Langerman, Mark Jones, Kathrin Plath, Daniel Coca, Ivana Barbaric, Paul Gokhale, Peter W Andrews
Human embryonic stem cells (hESCs) display substantial heterogeneity in gene expression, implying the existence of discrete substates within the stem cell compartment. To determine whether these substates impact fate decisions of hESCs we used a GFP reporter line to investigate the properties of fractions of putative undifferentiated cells defined by their differential expression of the endoderm transcription factor, GATA6, together with the hESC surface marker, SSEA3. By single-cell cloning, we confirmed that substates characterized by expression of GATA6 and SSEA3 include pluripotent stem cells capable of long-term self-renewal...
May 9, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29779552/using-echo-clinics-to-promote-capacity-building-in-clinical-supervision
#6
Michael J Chaple, Thomas E Freese, Beth A Rutkowski, Laurie Krom, Andrew S Kurtz, James A Peck, Paul Warren, Susan Garrett
INTRODUCTION: Project Extension for Community Healthcare Outcomes (ECHO™) is a hub-and-spoke knowledge-sharing network, led by expert teams who use multipoint videoconferencing to conduct virtual clinics with community providers in order to improve the quality of care. For this project, members of the Addiction Technology Transfer Center network applied this model in order to enhance workforce capacity to deliver clinical supervision for the treatment of substance use disorders. METHODS: Clinical supervisors (n=66) employed in substance use disorder treatment programs were recruited to participate in this pilot study...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29775983/classification-and-microvascular-flap-selection-for-anterior-cranial-fossa-reconstruction
#7
James D Vargo, Wojciech Przylecki, Paul J Camarata, Brian T Andrews
BACKGROUND:  Microvascular reconstruction of the anterior cranial fossa (ACF) creates difficult challenges. Reconstructive goals and flap selection vary based on the defect location within the ACF. This study evaluates the feasibility and reliability of free tissue transfer for salvage reconstruction of low, middle, and high ACF defects. METHODS:  A retrospective review was performed. Reconstructions were anatomically classified as low (anterior skull base), middle (frontal bar/sinus), and high (frontal bone/soft tissue)...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29774967/re-optimization-of-the-organocatalyzed-double-aldol-domino-process-to-a-key-enal-intermediate-and-its-application-to-the-total-synthesis-of-%C3%AE-%C3%A2-%C3%A2-prostaglandin-j%C3%A2
#8
Andrejs Pelss, Narasimhulu Gandhamsetty, James Robin Smith, Damien Mailhol, Mattia Silvi, Andrew Watson, Isabel Perez-Powell, Sébastien Prévost, Nina Schützenmeister, Peter Moore, Varinder Kumar Aggarwal
Re-investigation of the L-proline catalyzed double aldol cascade dimerization of succinaldehyde for the synthesis of a key bicyclic enal intermediate, pertinent in the field of stereoselective prostaglandin synthesis, is reported. The yield of this process has been more than doubled, from 14% to a 29% isolated yield on a multi-gram scale (32% NMR yield), through conducting a detailed study of the reaction solvent, temperature and concentration, as well as a catalyst screen. The synthetic utility of this enal intermediate has been further demonstrated through the total synthesis of Δ¹²-prostaglandin J₃, a compound with known anti-leukemic properties...
May 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29774294/seroprevalence-and-awareness-of-porcine-cysticercosis-across-different-pig-production-systems-in-south-central-cambodia
#9
Aderosoye Adenuga, Ana Mateus, Chhay Ty, Khieu Borin, Davun Holl, Sorn San, Victoria Duggan, Madeleine Clark, Gavin J D Smith, Richard Coker, Andrew Vaughn, James W Rudge
Background: Taeniasis/cysticercosis, caused by the pork tapeworm Taenia solium , represents an important public health and economic burden in endemic countries. However, there is a paucity of data on infection among pigs in many parts of Southeast Asia, particularly Cambodia. We aimed to estimate seroprevalence of porcine cysticercosis, and investigate husbandary practices and knowledge of the disease among livestock workers, across different pig sector units in south-central Cambodia...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774223/endoscopic-electrohydraulic-lithotripsy-for-large-bowel-obstruction-secondary-to-colonic-gallstone-impaction
#10
Daniel Hughes, James Kynaston, David Messenger, Efstratios Alexandridis, Andrew Strickland, A J Portal
Large bowel obstruction secondary to colonic gallstone impaction is rare. We report an elderly patient who presented with colonic obstruction secondary to impaction of a gallstone in a diverticular segment of his sigmoid colon. He had severe comorbidities that precluded surgery, and it was not possible to remove the gallstone using standard endoscopic techniques. Endoscopic electrohydraulic lithotripsy (EHL) was performed to fracture the gallstone, and fragments were successfully removed. For comorbid patients who are not fit for general anesthesia, endoscopic stone retrieval should be considered...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29774127/paf1-complex-interactions-with-setdb1-mediate-promoter-h3k9-methylation-and-transcriptional-repression-of-hoxa9-and-meis1-in-acute-myeloid-leukemia
#11
James Ropa, Nirmalya Saha, Zhiling Chen, Justin Serio, Wei Chen, Dattatreya Mellacheruvu, Lili Zhao, Venkatesha Basrur, Alexey I Nesvizhskii, Andrew G Muntean
The Polymerase Associated Factor 1 complex (PAF1c) is an epigenetic co-modifying complex that directly contacts RNA polymerase II (RNAPII) and several epigenetic regulating proteins. Mutations, overexpression and loss of expression of subunits of the PAF1c are observed in various forms of cancer suggesting proper regulation is needed for cellular development. However, the biochemical interactions with the PAF1c that allow dynamic gene regulation are unclear. We and others have shown that the PAF1c makes a direct interaction with MLL fusion proteins, which are potent oncogenic drivers of acute myeloid leukemia (AML)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773857/development-and-worldwide-use-of-non-lethal-and-minimal-population-level-impact-protocols-for-the-isolation-of-amphibian-chytrid-fungi
#12
Matthew C Fisher, Pria Ghosh, Jennifer M G Shelton, Kieran Bates, Lola Brookes, Claudia Wierzbicki, Gonçalo M Rosa, Rhys A Farrer, David M Aanensen, Mario Alvarado-Rybak, Arnaud Bataille, Lee Berger, Susanne Böll, Jaime Bosch, Frances C Clare, Elodie A Courtois, Angelica Crottini, Andrew A Cunningham, Thomas M Doherty-Bone, Fikirte Gebresenbet, David J Gower, Jacob Höglund, Timothy Y James, Thomas S Jenkinson, Tiffany A Kosch, Carolina Lambertini, Anssi Laurila, Chun-Fu Lin, Adeline Loyau, An Martel, Sara Meurling, Claude Miaud, Pete Minting, Serge Ndriantsoa, Simon J O'Hanlon, Frank Pasmans, Tsanta Rakotonanahary, Falitiana C E Rabemananjara, Luisa P Ribeiro, Dirk S Schmeller, Benedikt R Schmidt, Lee Skerratt, Freya Smith, Claudio Soto-Azat, Giulia Tessa, Luís Felipe Toledo, Andrés Valenzuela-Sánchez, Ruhan Verster, Judit Vörös, Bruce Waldman, Rebecca J Webb, Che Weldon, Emma Wombwell, Kelly R Zamudio, Joyce E Longcore, Trenton W J Garner
Parasitic chytrid fungi have emerged as a significant threat to amphibian species worldwide, necessitating the development of techniques to isolate these pathogens into culture for research purposes. However, early methods of isolating chytrids from their hosts relied on killing amphibians. We modified a pre-existing protocol for isolating chytrids from infected animals to use toe clips and biopsies from toe webbing rather than euthanizing hosts, and distributed the protocol to researchers as part of the BiodivERsA project RACE; here called the RML protocol...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29771720/cross-circulation-and-the-early-days-of-cardiac-surgery
#13
Vincent L Gott, James H Moller, Andrew W Shaffer, Sara J Shumway
No abstract text is available yet for this article.
May 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29771539/psi4numpy-an-interactive-quantum-chemistry-programming-environment-for-reference-implementations-and-rapid-development
#14
Daniel G A Smith, Lori A Burns, Dominic A Sirianni, Daniel R Nascimento, Ashutosh Kumar, Andrew M James, Jeffrey B Schriber, Tianyuan Zhang, Boyi Zhang, Adam S Abbott, Eric J Berquist, Marvin H Lechner, Leonardo A Cunha, Alexander G Heide, Jonathan M Waldrop, Tyler Y Takeshita, Asem Alenaizan, Daniel Neuhauser, Rollin A King, Andrew C Simmonett, Justin M Turney, Henry F Schaefer, Francesco A Evangelista, A Eugene DePrince, T Daniel Crawford, Konrad Patkowski, C David Sherrill
Psi4NumPy demonstrates the use of efficient computational kernels from the open-source Psi4 program through the popular NumPy library for linear algebra in Python to facilitate the rapid development of clear, understandable Python computer code for new quantum chemical methods, while maintaining a relatively low execution time. Using these tools, reference implementations have been created for a number of methods, including self-consistent field (SCF), SCF response, many-body perturbation theory, coupled-cluster theory, configuration interaction, and symmetry-adapted perturbation theory...
May 17, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29771449/intraspecific-variation-in-indirect-plant-soil-feedbacks-influences-a-wetland-plant-invasion
#15
Warwick J Allen, Laura A Meyerson, Andrew J Flick, James T Cronin
Plant-soil feedbacks (PSFs) influence plant competition via direct interactions with pathogens and mutualists or indirectly via apparent competition/mutualisms (i.e., spillover to co-occurring plants) and soil legacy effects. It is currently unknown how intraspecific variation in PSFs interacts with the environment (e.g., nutrient availability) to influence competition between native and invasive plants. We conducted a fully crossed multi-factor greenhouse experiment to determine the effects of Phragmites australis rhizosphere soil biota, interspecific competition, and nutrient availability on biomass of replicate populations from one native and two invasive lineages of common reed (P...
May 17, 2018: Ecology
https://www.readbyqxmd.com/read/29771323/multiple-regions-of-a-cortical-network-commonly-encode-the-meaning-of-words-in-multiple-grammatical-positions-of-read-sentences
#16
Andrew James Anderson, Edmund C Lalor, Feng Lin, Jeffrey R Binder, Leonardo Fernandino, Colin J Humphries, Lisa L Conant, Rajeev D S Raizada, Scott Grimm, Xixi Wang
Deciphering how sentence meaning is represented in the brain remains a major challenge to science. Semantically related neural activity has recently been shown to arise concurrently in distributed brain regions as successive words in a sentence are read. However, what semantic content is represented by different regions, what is common across them, and how this relates to words in different grammatical positions of sentences is weakly understood. To address these questions, we apply a semantic model of word meaning to interpret brain activation patterns elicited in sentence reading...
May 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29766741/simultaneous-intraoperative-measurement-of-cadaver-ankle-and-subtalar-joint-compression-during-arthrodesis-with-intramedullary-nail-screws-and-tibiotalocalcaneal-plate
#17
Kamran S Hamid, Richard R Glisson, Joel G Morash, Andrew P Matson, James K DeOrio
BACKGROUND: Suboptimal tibiotalocalcaneal arthrodesis (TTCA) fusion rates may result from inadequate compression that increases motion and interferes with bony bridging. The aim of this study was to evaluate compressive forces at the ankle and subtalar joints with 3 contemporary TTCA constructs. METHODS: Thirty fresh-frozen cadaveric lower extremity specimens were divided into 3 groups of 10 each: 3 partially threaded cannulated screws, hindfoot nail, and lateral plate...
May 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29765086/fabrication-and-characterization-of-a-scalable-surface-textured-with-pico-liter-oil-drops-for-mechanistic-studies-of-bacteria-oil-interactions
#18
Maryam Jalali, Andrew R White, James Marti, Jian Sheng
Texturing a large surface with oily micro-drops with controlled size, shape and volume provides an unprecedented capability in investigating complex interactions of bacteria, cells and interfaces. It has particular implications in understanding key microbial processes involved in remediation of environmental disasters, such as Deepwater Horizon oil spill. This work presents a development of scalable micro-transfer molding to functionalize a substrate with oily drop array to generate a microcosm mimicking bacteria encountering a rising droplet cloud...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764948/inducible-lung-epithelial-resistance-requires-multisource-reactive-oxygen-species-generation-to-protect-against-viral-infections
#19
Carson T Kirkpatrick, Yongxing Wang, Miguel M Leiva Juarez, Pooja Shivshankar, Jezreel Pantaleón García, Alexandria K Plumer, Vikram V Kulkarni, Hayden H Ware, Fahad Gulraiz, Miguel A Chavez Cavasos, Gabriela Martinez Zayes, Shradha Wali, Andrew P Rice, Hongbing Liu, James M Tour, William K A Sikkema, Ana S Cruz Solbes, Keith A Youker, Michael J Tuvim, Burton F Dickey, Scott E Evans
Viral pneumonias cause profound worldwide morbidity, necessitating novel strategies to prevent and treat these potentially lethal infections. Stimulation of intrinsic lung defenses via inhalation of synergistically acting Toll-like receptor (TLR) agonists protects mice broadly against pneumonia, including otherwise-lethal viral infections, providing a potential opportunity to mitigate infectious threats. As intact lung epithelial TLR signaling is required for the inducible resistance and as these cells are the principal targets of many respiratory viruses, the capacity of lung epithelial cells to be therapeutically manipulated to function as autonomous antiviral effectors was investigated...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29764913/mapping-and-characterizing-n6-methyladenine-in-eukaryotic-genomes-using-single-molecule-real-time-sequencing
#20
Shijia Zhu, John Beaulaurier, Gintaras Deikus, Tao Wu, Maya Strahl, Ziyang Hao, Guanzheng Luo, James A Gregory, Andrew Chess, Chuan He, Andrew Xiao, Robert Sebra, Eric E Schadt, Gang Fang
N6-methyladenine (m6dA) has been discovered as a novel form of DNA methylation prevalent in eukaryotes, however, methods for high resolution mapping of m6dA events are still lacking. Single-molecule real-time (SMRT) sequencing has enabled the detection of m6dA events at single-nucleotide resolution in prokaryotic genomes, but its application to detecting m6dA in eukaryotic genomes has not been rigorously examined. Herein, we identified unique characteristics of eukaryotic m6dA methylomes that fundamentally differ from those of prokaryotes...
May 15, 2018: Genome Research
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