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Eric L Vu, Craig G Rusin, Dan J Penny, Kathy K Kibler, Ronald Blaine Easley, Brendan Smith, Dean Andropoulos, Ken Brady
OBJECTIVE: We evaluated ST-segment monitoring to detect clinical decompensation in infants with single ventricle anatomy. We proposed a signal processing algorithm for ST-segment instability and hypothesized that instability is associated with cardiopulmonary arrests. DESIGN: Retrospective, observational study. SETTING: Tertiary children's hospital 21-bed cardiovascular ICU and 36-bed step-down unit. PATIENTS: Twenty single ventricle infants who received stage 1 palliation surgery between January 2013 and January 2014...
October 13, 2016: Pediatric Critical Care Medicine
David R Busch, Craig G Rusin, Wanda Miller-Hance, Kathy Kibler, Wesley B Baker, Jeffrey S Heinle, Charles D Fraser, Arjun G Yodh, Daniel J Licht, Kenneth M Brady
While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement...
September 1, 2016: Biomedical Optics Express
Simon J Roche, Lennard Funk, Aaron Sciascia, W Ben Kibler
The scapula fulfils many roles to facilitate optimal function of the shoulder. Normal function of the shoulder joint requires a scapula that can be properly aligned in multiple planes of motion of the upper extremity. Scapular dyskinesis, meaning abnormal motion of the scapula during shoulder movement, is a clinical finding commonly encountered by shoulder surgeons. It is best considered an impairment of optimal shoulder function. As such, it may be the underlying cause or the accompanying result of many forms of shoulder pain and dysfunction...
October 2015: Shoulder & Elbow
Tierra R Farris, Paige S Dunphy, Bing Zhu, Clayton E Kibler, Jere W McBride
Ehrlichia chaffeensis is an obligately intracellular bacterium that reprograms the mononuclear phagocyte through diverse effector-host interactions to modulate numerous host cell processes, including transcription. In a previous study, we reported that E. chaffeensis TRP32, a type 1 secreted effector, interacts with multiple host nucleus-associated proteins and also auto-activates reporter gene expression in yeast. In this study, we demonstrate that TRP32 is a nucleomodulin that binds host DNA and alters host gene transcription...
August 29, 2016: Infection and Immunity
William D Arndt, Stacy D White, Brian P Johnson, Trung Huynh, Jeffrey Liao, Heather Harrington, Samantha Cotsmire, Karen V Kibler, Jeffrey Langland, Bertram L Jacobs
Monkeypox virus (MPXV) infection fails to activate the host anti-viral protein, PKR, despite lacking a full-length homologue of the vaccinia virus (VACV) PKR inhibitor, E3. Since PKR can be activated by dsRNA produced during a viral infection, we have analyzed the accumulation of dsRNA in MPXV-infected cells. MPXV infection led to less accumulation of dsRNA than VACV infection. Because in VACV infections accumulation of abnormally low amounts of dsRNA is associated with mutations that lead to resistance to the anti-poxvirus drug isatin beta-thiosemicarbazone (IBT), we investigated the effects of treatment of MPXV-infected cells with IBT...
October 2016: Virology
Eric Van Belle, Antoine Rauch, Flavien Vincent, Emmanuel Robin, Marion Kibler, Julien Labreuche, Emmanuelle Jeanpierre, Marie Levade, Christopher Hurt, Natacha Rousse, Jean-Baptiste Dally, Nicolas Debry, Jean Dallongeville, Andre Vincentelli, Cedric Delhaye, Jean-Luc Auffray, Francis Juthier, Guillaume Schurtz, Gilles Lemesle, Thibault Caspar, Olivier Morel, Nicolas Dumonteil, Alain Duhamel, Camille Paris, Annabelle Dupont-Prado, Paulette Legendre, Frederic Mouquet, Berenice Marchant, Sylvie Hermoire, Delphine Corseaux, Karim Moussa, Aurelie Manchuelle, Jean-Jacques Bauchart, Valentin Loobuyck, Claudine Caron, Christophe Zawadzki, Fabrice Leroy, Jean-Christophe Bodart, Bart Staels, Jenny Goudemand, Peter J Lenting, Sophie Susen
BACKGROUND: Postprocedural aortic regurgitation occurs in 10 to 20% of patients undergoing transcatheter aortic-valve replacement (TAVR) for aortic stenosis. We hypothesized that assessment of defects in high-molecular-weight (HMW) multimers of von Willebrand factor or point-of-care assessment of hemostasis could be used to monitor aortic regurgitation during TAVR. METHODS: We enrolled 183 patients undergoing TAVR. Patients with aortic regurgitation after the initial implantation, as identified by means of transesophageal echocardiography, underwent additional balloon dilation to correct aortic regurgitation...
July 28, 2016: New England Journal of Medicine
Mindy Ma, Lydia R Malcolm, Kristine Díaz-Albertini, Juan Carlos Sánchez, Brett Simpson, Lissette Cortes, Jeffrey L Kibler
Research on cultural factors and substance use among Hispanic adolescents has focused primarily on acculturation, while specific core Hispanic values and attributes have received minimal attention. The objective of the current study was to examine the relationship between traditional Hispanic cultural assets and substance use among adolescents. A purposive sample of 225 Hispanic adolescents (47% male) aged 13 to 16 years were recruited from community venues (e.g., park, school, mall) in a predominately Hispanic neighborhood...
July 21, 2016: Health Education & Behavior: the Official Publication of the Society for Public Health Education
O Kimmoun, H C Hsu, H Branger, M S Li, Y Y Chen, C Kharif, M Onorato, E J R Kelleher, B Kibler, N Akhmediev, A Chabchoub
Instabilities are common phenomena frequently observed in nature, sometimes leading to unexpected catastrophes and disasters in seemingly normal conditions. One prominent form of instability in a distributed system is its response to a harmonic modulation. Such instability has special names in various branches of physics and is generally known as modulation instability (MI). The MI leads to a growth-decay cycle of unstable waves and is therefore related to Fermi-Pasta-Ulam (FPU) recurrence since breather solutions of the nonlinear Schrödinger equation (NLSE) are known to accurately describe growth and decay of modulationally unstable waves in conservative systems...
2016: Scientific Reports
N A Kibler, S V Akhmetzianova, V P Nuzhny
Repolarization properties of ventricular myocardium were studied in anesthetized adult dogs of both sexes subjected to antiorthostatic hypokinesia (head-down tilt at 45° and 60° to the horizontal) and during recovery period (horizontal position for 15 min). The time of repolarization of ventricular myocardium during recovery surpassed the initial value, which represents an adaptive response of the heart to antiorthostasis.
June 2016: Bulletin of Experimental Biology and Medicine
Natalie L Myers, Aaron D Sciascia, W Ben Kibler, Tim L Uhl
BACKGROUND: A sport-specific conditioning program can help tennis players train for competition or return to play from injury. This study determined the actual tennis serve volume in elite play and used these data to construct an interval training program based on stroke volume. HYPOTHESIS: There will be no differences in serve volume between male and female tennis players at the professional and junior levels. STUDY DESIGN: Retrospective cohort study...
July 1, 2016: Sports Health
Brian W Woodrum, Jason Maxwell, Denysia M Allen, Jennifer Wilson, Lauren R H Krumpe, Andrey A Bobkov, R Blake Hill, Karen V Kibler, Barry R O'Keefe, Giovanna Ghirlanda
Cyanovirin-N (CV-N) is an antiviral lectin with potent activity against enveloped viruses, including HIV. The mechanism of action involves high affinity binding to mannose-rich glycans that decorate the surface of enveloped viruses. In the case of HIV, antiviral activity of CV-N is postulated to require multivalent interactions with envelope protein gp120, achieved through a pseudo-repeat of sequence that adopts two near-identical glycan-binding sites, and possibly involves a 3D-domain-swapped dimeric form of CV-N...
2016: Viruses
Christopher J Rhee, Charles D Fraser, Kathleen Kibler, Ronald B Easley, Dean B Andropoulos, Marek Czosnyka, Georgios V Varsos, Peter Smielewski, Craig G Rusin, Ken M Brady, Jeffrey R Kaiser
Premature infants are at risk of vascular neurological insults. Hypotension and hypertension are considered injurious, but neither condition is defined with consensus. Critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow ceases. CrCP may serve to define subject-specific low or high ABP. Our objective was to quantify CrCP as a function of gestational age (GA). One hundred eighty-six premature infants with a GA range of 23-33 weeks, were monitored with umbilical artery catheters and transcranial Doppler insonation of middle cerebral artery flow velocity (FV) for 1-h sessions over the first week of life...
2016: Acta Neurochirurgica. Supplement
Matthew Pesek, Kathleen Kibler, R Blaine Easley, Jennifer Mytar, Christopher Rhee, Dean Andropolous, Ken Brady
BACKGROUND: The upper limit of cerebrovascular pressure autoregulation (ULA) is inadequately characterized. We sought to delineate the ULA in a neonatal swine model. METHODS: Neonatal piglets with sham surgery (n = 9), interventricular fluid infusion (INF; n = 10), controlled cortical impact (CCI; n = 10), or impact + infusion (CCI + INF; n = 11) had intracranial pressure monitoring and bilateral cortical laser-Doppler flux recordings during arterial hypertension until lethality...
2016: Acta Neurochirurgica. Supplement
Christopher J Rhee, Charles D Fraser, Kathleen Kibler, Ronald B Easley, Dean B Andropoulos, Marek Czosnyka, Georgios V Varsos, Peter Smielewski, Craig G Rusin, Ken M Brady, Jeffrey R Kaiser
Our objective was to quantify cerebrovascular autoregulation as a function of gestational age (GA) and across the phases of the cardiac cycle. One hundred eighty-six premature infants, with a GA range of 23-33 weeks, were monitored using umbilical artery catheters and transcranial Doppler insonation of middle cerebral artery flow velocity (FV) for 1-h sessions over the first week of life. Autoregulation was quantified as a moving correlation coefficient between systolic arterial blood pressure (ABP) and systolic FV (Sx); mean ABP and mean FV (Mx); diastolic ABP and diastolic FV (Dx)...
2016: Acta Neurochirurgica. Supplement
Christopher J Rhee, Kathleen K Kibler, R Blaine Easley, Dean B Andropoulos, Marek Czosnyka, Peter Smielewski, Georgios V Varsos, Ken M Brady, Craig G Rusin, Charles D Fraser, C Heath Gauss, D Keith Williams, Jeffrey R Kaiser
Premature infants are at an increased risk of intraventricular hemorrhage (IVH). The roles of hypotension and hyperemia are still debated. Critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow (CBF) ceases. When diastolic ABP is equal to CrCP, CBF occurs only during systole. The difference between diastolic ABP and CrCP is the diastolic closing margin (DCM). We hypothesized that a low DCM was associated with IVH. One hundred eighty-six premature infants, with a gestational age (GA) range of 23-33 weeks, were monitored with umbilical artery catheters and transcranial Doppler insonation of middle cerebral artery flow velocity for 1-h sessions over the first week of life...
2016: Acta Neurochirurgica. Supplement
Christopher J Rhee, Jeffrey R Kaiser, Danielle R Rios, Kathleen K Kibler, R Blaine Easley, Dean B Andropoulos, Marek Czosnyka, Peter Smielewski, Georgios V Varsos, Craig G Rusin, C Heath Gauss, D Keith Williams, Ken M Brady
OBJECTIVE: To determine whether the diastolic closing margin (DCM), defined as diastolic blood pressure minus critical closing pressure, is associated with the development of early severe intraventricular hemorrhage (IVH). STUDY DESIGN: A reanalysis of prospectively collected data was conducted. Premature infants (gestational age 23-31 weeks) receiving mechanical ventilation (n = 185) had ∼1-hour continuous recordings of umbilical arterial blood pressure, middle cerebral artery cerebral blood flow velocity, and PaCO2 during the first week of life...
July 2016: Journal of Pediatrics
Stephanie D Moore-Reed, W Ben Kibler, Natalie L Myers, Belinda J Smith
BACKGROUND: Alterations in glenohumeral (GH) rotation especially internal rotation and total range of motion have been associated with altered GH kinematics and susceptibility to injury. Researchers have evaluated long-term change in baseball and tennis players, and short-term changes in baseball players. However, acute (short-term) changes in GH rotation have not been evaluated in tennis players. HYPOTHESES/PURPOSE: The purpose of this study was to quantify short-term glenohumeral rotational changes within a group of professional women's tennis players following competitive play...
April 2016: International Journal of Sports Physical Therapy
Gerard Zurawski, Sandra Zurawski, Anne-Laure Flamar, Laura Richert, Ralf Wagner, Georgia D Tomaras, David C Montefiori, Mario Roederer, Guido Ferrari, Christine Lacabaratz, Henri Bonnabau, Peter Klucar, Zhiqing Wang, Kathryn E Foulds, Shing-Fen Kao, Nicole L Yates, Celia LaBranche, Bertram L Jacobs, Karen Kibler, Benedikt Asbach, Alexander Kliche, Andres Salazar, Steve Reed, Steve Self, Raphael Gottardo, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Rodolphe Thiebaut, Giuseppe Pantaleo, Yves Levy
Improved antigenicity against HIV-1 envelope (Env) protein is needed to elicit vaccine-induced protective immunity in humans. Here we describe the first tests in non-human primates (NHPs) of Env gp140 protein fused to a humanized anti-LOX-1 recombinant antibody for delivering Env directly to LOX-1-bearing antigen presenting cells, especially dendritic cells (DC). LOX-1, or 1ectin-like oxidized low-density lipoprotein (LDL) receptor-1, is expressed on various antigen presenting cells and endothelial cells, and is involved in promoting humoral immune responses...
2016: PloS One
Gordon I Groh, Mark A Mighell, Carl J Basamania, W Ben Kibler
The clavicle is the most frequently injured bone in the human body. In most cases, fractures that occur in the midshaft of the clavicle can be managed nonsurgically. An increasing number of studies suggest that displaced midshaft clavicle fractures have improved outcomes after surgical management, and equivalent outcomes can be achieved with both plating and intramedullary techniques. Distal clavicle fractures are managed according to the disruption of the coracoclavicular ligaments. Fractures with disruption of the ligaments usually will require fixation, whereas fractures with intact ligaments may be treated with closed management...
2016: Instructional Course Lectures
Joshua D Harris
Both the quality and quantity of reporting in the SLAP repair literature, especially the surgical indications and technical intraoperative characteristics, leaves significant room for improvement. In their systematic review, Kibler and Sciascia identify this considerable underlying imprecision. Based on the current literature, no consensus exists for establishing any criteria for a successful SLAP repair--surgical indications, characteristics (type, location, number of anchors), completeness of repair, or rehabilitation...
April 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
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