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Antonio G Cabrera, Kathleen K Kibler, R Blaine Easley, Michelle Goldsworthy, Lara S Shekerdemian, Dean B Andropoulos, Jeffrey Heinle, Erin A Gottlieb, Eric Vu, Ken M Brady
BACKGROUND: Elevated arterial blood pressure (ABP) is common after superior bidirectional cavo-pulmonary anastomosis (BCPA). The effects of elevated ABP after BCPA on cerebrovascular hemodynamics are unknown. We sought to determine the relationship between elevated ABP and cerebrovascular autoregulation after BCPA. METHODS: Prospective, observational study on infants with single-ventricle physiology after BCPA surgery. Continuous recordings of mean ABP, mean cavo-pulmonary pressure (PAP), near-infrared spectroscopy measures of cerebral oximetry (rSO2), and relative cerebral blood volume index (BVI) were obtained from admission to extubation...
March 14, 2018: Pediatric Research
N A Kibler, V P Nuzhny, P V Nuzhny, O V Rogachevskaya
Pumping function of the heart ventricles under conditions of electrical stimulation was examined in adult dogs and rabbits. Pacing induced different changes in intracardiac hemodynamics manifested in impairment of pumping function of the right ventricle, which is largely determined by the functional state of the left ventricle. Initially high HR in rabbits more deeply limited functional reserve of the myocardium in response to electrical stimulus and was accompanied by more pronounced disturbances of pumping function of both ventricles...
March 3, 2018: Bulletin of Experimental Biology and Medicine
Kang Chen, Simin Deng, Yanhong Ma, Yelin Yao, Juan Chen, Yuqian Zhang
BACKGROUND: Evaluation of scapular dyskinesis is of clinical interest because it is believed to be associated with pathologies of the shoulder. This study investigated the feasibility of plain-film radiography in evaluating scapular dyskinesis. METHODS: Subjects with unilateral disorders of the shoulder (n = 186) who underwent plain-film radiography of bilateral scapulae were divided into 4 categories of scapular dyskinesis patterns according to the Kibler classification and analyzed...
February 15, 2018: Journal of Shoulder and Elbow Surgery
Monica G Lawrence, Thamiris V Palacios-Kibler, Lisa J Workman, Alexander J Schuyler, John W Steinke, Spencer C Payne, Emily C McGowan, James Patrie, Ramsay L Fuleihan, Kathleen E Sullivan, Patricia L Lugar, Camellia L Hernandez, Douglas E Beakes, James W Verbsky, Thomas A E Platts-Mills, Charlotte Cunningham-Rundles, John M Routes, Larry Borish
Although small prior studies have suggested that IgE can be low in common variable immunodeficiency (CVID), the workup for patients with recurrent infections and suspected hypogammaglobulinemia does not include the routine measurement of serum IgE. We sought to test the hypothesis that low/undetectable serum IgE is characteristic of CVID by comparing the frequency of low/undetectable serum IgE in healthy controls and patients with CVID. We measured total serum IgE in a large multi-center cohort of patients with CVID (n = 354) and compared this to large population-based cohorts of children and adults...
February 17, 2018: Journal of Clinical Immunology
Kevin O Saunders, Sampa Santra, Robert Parks, Nicole L Yates, Laura L Sutherland, Richard M Scearce, Harikrishnan Balachandran, Todd Bradley, Derrick Goodman, Amanda Eaton, Sherry A Stanfield-Oakley, James Tartaglia, Sanjay Phogat, Giuseppe Pantaleo, Mariano Esteban, Carmen E Gomez, Beatriz Perdiguero, Bertram Jacobs, Karen Kibler, Bette Korber, David C Montefiori, Guido Ferrrari, Nathan Vandergrift, Hua-Xin Liao, Georgia D Tomaras, Barton F Haynes
A preventive HIV-1 vaccine is an essential part of the strategy to eradicate AIDS. A critical question is whether antibodies that do not neutralize primary isolate (tier 2) HIV-1 viruses can protect from infection. Here, we investigated the ability of an attenuated poxvirus vector (NYVAC) prime-envelope gp120 boost to elicit potentially protective antibody responses in a rhesus macaque model of mucosal simian-human immunodeficiency virus (SHIV) infection. NYVAC vector delivery of a group M consensus envelope, trivalent mosaic envelopes, or a natural clade B isolate B...
February 7, 2018: Journal of Virology
Jessica Ristorto, Nathan Messas, Benjamin Marchandot, Marion Kibler, Sébastien Hess, Nicolas Meyer, Michael Schaeffer, Nicolas Tuzin, Patrick Ohlmann, Laurence Jesel, Olivier Morel
AIM: In percutaneous coronary intervention (PCI)-treated acute coronary syndrome (ACS) patients on clopidogrel therapy, high on-treatment platelet adenosine diphosphate (ADP) reactivity was observed in numerous studies, with significant increases in non-fatal myocardial infarction, definite/probable stent thrombosis, or cardiovascular mortality. Compared to clopidogrel, prasugrel and ticagrelor provide more potent platelet inhibition. Whether new P2Y12 inhibitors reduce thrombotic events in a similar manner compared to the rate observed with appropriate P2Y12 inhibition by clopidogrel must still be determined...
February 8, 2018: Journal of Atherosclerosis and Thrombosis
Jeffrey L Kibler
Beyond the construct of cardiovascular reactivity, the measurement of cardiovascular recovery from stress represents an important index of exaggerated physiological arousal and disease risk. Cardiovascular recovery in posttraumatic stress disorder (PTSD) has not received adequate attention. The present study examined whether cardiovascular recovery following an oral speaking stressor was associated with the severity of PTSD symptoms, and whether cognitive stress appraisals of threat and challenge were significantly associated with PTSD severity and recovery...
February 1, 2018: Journal of Traumatic Stress
James K Jankovich, Dave Chapman, Debra T Hansen, Mark D Robida, Andrey Loskutov, Felicia Craciunescu, Alex Borovkov, Karen Kibler, Lynnette Goatley, Katherine King, Christopher L Netherton, Geraldine Taylor, Bertram Jacobs, Kathryn Sykes, Linda K Dixon
African swine fever virus (ASFV) causes an acute haemorrhagic fever in domestic pigs with high socio-economic impact. No vaccine is available limiting options for control. Although live attenuated ASFV can induce up to one hundred percent protection against lethal challenge, little is known of the antigens which induce this protective response. To identify additional ASFV immunogenic and potentially protective antigens we cloned 47 viral genes in individual plasmids for gene vaccination and in recombinant vaccinia viruses...
January 31, 2018: Journal of Virology
Kelly M Kibler, Debra Reinhart, Christopher Hawkins, Amir Mohaghegh Motlagh, James Wright
Throughout the world, much food produced is wasted. The resource impact of producing wasted food is substantial; however, little is known about the energy and water consumed in managing food waste after it has been disposed. Herein, we characterize food waste within the Food-Energy-Water (FEW) nexus and parse the differential FEW effects of producing uneaten food and managing food loss and waste. We find that various food waste management options, such as waste prevention, landfilling, composting, anaerobic digestion, and incineration, present variable pathways for FEW impacts and opportunities...
January 20, 2018: Waste Management
M L Kibler, D L Pendell, M Costanigro, J Traub-Dargatz
BACKGROUND: Equine injury and disease cause two types of costs for those financially responsible for treating and caring for the infected horse(s); direct costs of treating the horse and indirect cost of lost use of the horse for a period of time to the user of the horse (daily horse use). Indirect costs are more difficult to estimate but pose significant financial implications for equine-owners/caregivers. Additionally, there exists a gap in existing research regarding the valuation of infectious treatment options in horses...
November 24, 2017: Equine Veterinary Journal
Indrani Mukhopadhya, Sarah Moraïs, Jenny Laverde-Gomez, Paul O Sheridan, Alan W Walker, William Kelly, Athol V Klieve, Diane Ouwerkerk, Sylvia H Duncan, Petra Louis, Nicole Koropatkin, Darrell Cockburn, Ryan Kibler, Philip J Cooper, Carlos Sandoval, Emmanuelle Crost, Nathalie Juge, Edward A Bayer, Harry J Flint
Ruminococcus bromii is a dominant member of the human colonic microbiota that plays a 'keystone' role in degrading dietary resistant starch. Recent evidence from one strain has uncovered a unique cell surface 'amylosome' complex that organizes starch-degrading enzymes. New genome analysis presented here reveals further features of this complex and shows remarkable conservation of amylosome components between human colonic strains from three different continents and a R. bromii strain from the rumen of Australian cattle...
January 2018: Environmental Microbiology
Karol Tarnowski, Tadeusz Martynkien, Paweł Mergo, Krzysztof Poturaj, Alicja Anuszkiewicz, Pierre Béjot, Franck Billard, Olivier Faucher, Bertrand Kibler, Waclaw Urbanczyk
We demonstrate a polarized all-normal dispersion supercontinuum generated in a birefringent silica microstructured fiber spanning beyond 2.5 µm. To our knowledge, this is the spectra reaching the furthest in mid-infrared ever generated in normal dispersion silica fibers. The generation process was studied experimentally and numerically with 70 fs pump pulses operating at different wavelengths on short propagation distances of 48 mm and 122 mm. The all-normal operation was limited by the zero-dispersion wavelength at 2...
October 30, 2017: Optics Express
Benjamin Marchandot, Nathan Messas, Laurence Jesel, Annie Trinh, Marion Kibler, Antje Reydel, Patrick Ohlmann, Olivier Morel
Except for bleeding complications, vitamin K antagonists (VKAs) are known to have few undesirable side effects. Herein is presented the case of a 45-year-old woman in whom liver damage was induced by fluindione and warfarin after mitral valve replacement. Hepatotoxicity is a rare complication of VKAs, both in the French National and Drug Safety registry and the medical literature. A diagnosis of VKA-induced drug damage was confirmed by the absence of other etiologies, the chronological sequence, recurrence after re-exposure to VKA, and rapid improvements after discontinuation of the drug...
May 2017: Journal of Heart Valve Disease
Heather Koehler, Samantha Cotsmire, Jeffrey Langland, Karen V Kibler, Daniel Kalman, Jason W Upton, Edward S Mocarski, Bertram L Jacobs
Vaccinia virus (VACV) encodes an innate immune evasion protein, E3, which contains an N-terminal Z-nucleic acid binding (Zα) domain that is critical for pathogenicity in mice. Here we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necroptosis. VACV deleted of the Zα domain of E3 (VACV-E3LΔ83N) induced rapid RIPK3-dependent cell death in IFN-treated L929 cells. Cell death was inhibited by the RIPK3 inhibitor, GSK872, and infection with this mutant virus led to phosphorylation and aggregation of MLKL, the executioner of necroptosis...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
R Wayne Litaker, William C Holland, D Ransom Hardison, Francesco Pisapia, Philipp Hess, Steven R Kibler, Patricia A Tester
Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP...
2017: PloS One
Frederic Audo, Sonia Boscolo, Julien Fatome, Bertrand Kibler, Christophe Finot
We propose and experimentally demonstrate a new approach to dramatically reduce the spectral broadening induced by self-phase modulation occurring in a Kerr medium. By using a temporal sinusoidal phase modulation, we efficiently cancel to a large extent the chirp induced by the nonlinear effect. Experimental validation carried out in a passive or amplifying fiber confirms the interest of the technique for the mitigation of the spectral expansion of long pulses.
August 1, 2017: Optics Letters
O Kimmoun, H C Hsu, B Kibler, A Chabchoub
The modulation instability (MI) is a universal mechanism that is responsible for the disintegration of weakly nonlinear narrow-banded wave fields and the emergence of localized extreme events in dispersive media. The instability dynamics is naturally triggered, when unstable energy sidebands located around the main energy peak are excited and then follow an exponential growth law. As a consequence of four wave mixing effect, these primary sidebands generate an infinite number of additional sidebands, forming a triangular sideband cascade...
August 2017: Physical Review. E
Ronald B Easley, Bradley S Marino, Jacky Jennings, Amy E Cassedy, Kathleen K Kibler, Ken M Brady, Dean B Andropoulos, Marissa Brunetti, Charles W Hogue, Eugenie S Heitmiller, Jennifer K Lee, James Spaeth, Allen D Everett
BACKGROUND: Cerebrovascular reactivity monitoring has been used to identify the lower limit of pressure autoregulation in adult patients with brain injury. We hypothesise that impaired cerebrovascular reactivity and time spent below the lower limit of autoregulation during cardiopulmonary bypass will result in hypoperfusion injuries to the brain detectable by elevation in serum glial fibrillary acidic protein level. METHODS: We designed a multicentre observational pilot study combining concurrent cerebrovascular reactivity and biomarker monitoring during cardiopulmonary bypass...
January 2018: Cardiology in the Young
Dheeraj Goswami, Katherine McLeod, Samantha Leonard, Kathleen Kibler, Ronald Blaine Easley, Charles D Fraser, Dean Andropoulos, Ken Brady
BACKGROUND: Clinical studies measuring cerebral blood flow in infants during deep hypothermia have demonstrated diminished cerebrovascular pressure autoregulation. The coexistence of hypotension in these cohorts confounds the conclusion that deep hypothermia impairs cerebrovascular pressure autoregulation. AIM: We sought to compare the lower limit of autoregulation and the static rate of autoregulation between normothermic and hypothermic piglets. METHODS: Twenty anesthetized neonatal piglets (5-7 days old; 10 normothermic and 10 hypothermic to 20°C) had continuous measurements of cortical red cell flux using laser Doppler flowmetry, while hemorrhagic hypotension was induced without cardiopulmonary bypass...
September 2017: Paediatric Anaesthesia
Brendan Smith, Eric Vu, Kathleen Kibler, Craig Rusin, Ronald B Easley, Dean Andropoulos, Jeffrey Heinle, Marek Czosnyka, Daniel Licht, Jennifer Lynch, Ken Brady
BACKGROUND: Autoregulation monitoring has been proposed as a means to identify optimal arterial blood pressure goals during cardiopulmonary bypass, but it has been observed that cerebral blood flow is pressure passive during hypothermic bypass. When neonates cooled during cardiopulmonary bypass are managed with vasodilators and controlled hypotension, it is not clear whether hypothermia or hypotension were the cause of impaired autoregulation. AIM: We sought to measure the effect of both arterial blood pressure and hypothermia on autoregulation in a cohort of infants cooled for bypass, hypothesizing a collinear relationship between hypothermia, hypotension, and dysautoregulation...
September 2017: Paediatric Anaesthesia
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