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https://www.readbyqxmd.com/read/29159997/sporulation-capability-and-amylosome-conservation-among-diverse-human-colonic-and-rumen-isolates-of-the-keystone-starch-degrader-ruminococcus-bromii
#1
Indrani Mukhopadhya, Sarah Morais, Jenny Laverde-Gomez, Paul O Sheridan, Alan W Walker, William Kelly, Athol V Klieve, Diane Ouwerkerk, Sylvia H Duncan, Petra Louis, Nicole Koropatkin, Darrell Cockburn, Ryan Kibler, Philip J Cooper, Carlos Sandoval, Emmanuelle Crost, Nathalie Juge, Edward A Bayer, Harry J Flint
Ruminococcus bromii is a dominant member of the human colonic microbiota that plays a 'keystone' role in degrading dietary resistant starch. Recent evidence from one strain has uncovered a unique cell surface 'amylosome' complex that organizes starch-degrading enzymes. New genome analysis presented here reveals further features of this complex and shows remarkable conservation of amylosome components between human colonic strains from three different continents and a R. bromii strain from the rumen of Australian cattle...
November 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29092218/polarized-all-normal-dispersion-supercontinuum-reaching-2-5-%C3%A2%C2%B5m-generated-in-a-birefringent-microstructured-silica-fiber
#2
Karol Tarnowski, Tadeusz Martynkien, Paweł Mergo, Krzysztof Poturaj, Alicja Anuszkiewicz, Pierre Béjot, Franck Billard, Olivier Faucher, Bertrand Kibler, Waclaw Urbanczyk
We demonstrate a polarized all-normal dispersion supercontinuum generated in a birefringent silica microstructured fiber spanning beyond 2.5 µm. To our knowledge, this is the spectra reaching the furthest in mid-infrared ever generated in normal dispersion silica fibers. The generation process was studied experimentally and numerically with 70 fs pump pulses operating at different wavelengths on short propagation distances of 48 mm and 122 mm. The all-normal operation was limited by the zero-dispersion wavelength at 2...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29092116/unexpected-problems-of-antithrombotic-therapy-with-an-unusual-side-effect-of-vitamin-k-antagonists-after-mitral-valve-replacement
#3
Benjamin Marchandot, Nathan Messas, Laurence Jesel, Annie Trinh, Marion Kibler, Antje Reydel, Patrick Ohlmann, Olivier Morel
Except for bleeding complications, vitamin K antagonists (VKAs) are known to have few undesirable side effects. Herein is presented the case of a 45-year-old woman in whom liver damage was induced by fluindione and warfarin after mitral valve replacement. Hepatotoxicity is a rare complication of VKAs, both in the French National and Drug Safety registry and the medical literature. A diagnosis of VKA-induced drug damage was confirmed by the absence of other etiologies, the chronological sequence, recurrence after re-exposure to VKA, and rapid improvements after discontinuation of the drug...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29073079/inhibition-of-dai-dependent-necroptosis-by-the-z-dna-binding-domain-of-the-vaccinia-virus-innate-immune-evasion-protein-e3
#4
Heather Koehler, Samantha Cotsmire, Jeffrey Langland, Karen V Kibler, Daniel Kalman, Jason W Upton, Edward S Mocarski, Bertram L Jacobs
Vaccinia virus (VACV) encodes an innate immune evasion protein, E3, which contains an N-terminal Z-nucleic acid binding (Zα) domain that is critical for pathogenicity in mice. Here we demonstrate that the N terminus of E3 is necessary to inhibit an IFN-primed virus-induced necroptosis. VACV deleted of the Zα domain of E3 (VACV-E3LΔ83N) induced rapid RIPK3-dependent cell death in IFN-treated L929 cells. Cell death was inhibited by the RIPK3 inhibitor, GSK872, and infection with this mutant virus led to phosphorylation and aggregation of MLKL, the executioner of necroptosis...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29045489/ciguatoxicity-of-gambierdiscus-and-fukuyoa-species-from-the-caribbean-and-gulf-of-mexico
#5
R Wayne Litaker, William C Holland, D Ransom Hardison, Francesco Pisapia, Philipp Hess, Steven R Kibler, Patricia A Tester
Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP...
2017: PloS One
https://www.readbyqxmd.com/read/28957203/nonlinear-spectrum-broadening-cancellation-by-sinusoidal-phase-modulation
#6
Frederic Audo, Sonia Boscolo, Julien Fatome, Bertrand Kibler, Christophe Finot
We propose and experimentally demonstrate a new approach to dramatically reduce the spectral broadening induced by self-phase modulation occurring in a Kerr medium. By using a temporal sinusoidal phase modulation, we efficiently cancel to a large extent the chirp induced by the nonlinear effect. Experimental validation carried out in a passive or amplifying fiber confirms the interest of the technique for the mitigation of the spectral expansion of long pulses.
August 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28950632/nonconservative-higher-order-hydrodynamic-modulation-instability
#7
O Kimmoun, H C Hsu, B Kibler, A Chabchoub
The modulation instability (MI) is a universal mechanism that is responsible for the disintegration of weakly nonlinear narrow-banded wave fields and the emergence of localized extreme events in dispersive media. The instability dynamics is naturally triggered, when unstable energy sidebands located around the main energy peak are excited and then follow an exponential growth law. As a consequence of four wave mixing effect, these primary sidebands generate an infinite number of additional sidebands, forming a triangular sideband cascade...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28835309/impaired-cerebral-autoregulation-and-elevation-in-plasma-glial-fibrillary-acidic-protein-level-during-cardiopulmonary-bypass-surgery-for-chd
#8
Ronald B Easley, Bradley S Marino, Jacky Jennings, Amy E Cassedy, Kathleen K Kibler, Ken M Brady, Dean B Andropoulos, Marissa Brunetti, Charles W Hogue, Eugenie S Heitmiller, Jennifer K Lee, James Spaeth, Allen D Everett
BACKGROUND: Cerebrovascular reactivity monitoring has been used to identify the lower limit of pressure autoregulation in adult patients with brain injury. We hypothesise that impaired cerebrovascular reactivity and time spent below the lower limit of autoregulation during cardiopulmonary bypass will result in hypoperfusion injuries to the brain detectable by elevation in serum glial fibrillary acidic protein level. METHODS: We designed a multicentre observational pilot study combining concurrent cerebrovascular reactivity and biomarker monitoring during cardiopulmonary bypass...
August 24, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28719038/static-cerebrovascular-pressure-autoregulation-remains-intact-during-deep-hypothermia
#9
Dheeraj Goswami, Katherine McLeod, Samantha Leonard, Kathleen Kibler, Ronald Blaine Easley, Charles D Fraser, Dean Andropoulos, Ken Brady
BACKGROUND: Clinical studies measuring cerebral blood flow in infants during deep hypothermia have demonstrated diminished cerebrovascular pressure autoregulation. The coexistence of hypotension in these cohorts confounds the conclusion that deep hypothermia impairs cerebrovascular pressure autoregulation. AIM: We sought to compare the lower limit of autoregulation and the static rate of autoregulation between normothermic and hypothermic piglets. METHODS: Twenty anesthetized neonatal piglets (5-7 days old; 10 normothermic and 10 hypothermic to 20°C) had continuous measurements of cortical red cell flux using laser Doppler flowmetry, while hemorrhagic hypotension was induced without cardiopulmonary bypass...
September 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28653463/does-hypothermia-impair-cerebrovascular-autoregulation-in-neonates-during-cardiopulmonary-bypass
#10
Brendan Smith, Eric Vu, Kathleen Kibler, Craig Rusin, Ronald B Easley, Dean Andropoulos, Jeffrey Heinle, Marek Czosnyka, Daniel Licht, Jennifer Lynch, Ken Brady
BACKGROUND: Autoregulation monitoring has been proposed as a means to identify optimal arterial blood pressure goals during cardiopulmonary bypass, but it has been observed that cerebral blood flow is pressure passive during hypothermic bypass. When neonates cooled during cardiopulmonary bypass are managed with vasodilators and controlled hypotension, it is not clear whether hypothermia or hypotension were the cause of impaired autoregulation. AIM: We sought to measure the effect of both arterial blood pressure and hypothermia on autoregulation in a cohort of infants cooled for bypass, hypothesizing a collinear relationship between hypothermia, hypotension, and dysautoregulation...
September 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28593098/reliability-and-validity-of-a-biomechanically-based-analysis-method-for-the-tennis-serve
#11
Natalie L Myers, W Ben Kibler, Leah Lamborn, Belinda J Smith, Tony English, Cale Jacobs, Tim L Uhl
BACKGROUND: An observational tennis serve analysis (OTSA) tool was developed using previously established body positions from three-dimensional kinematic motion analysis studies. These positions, defined as nodes, have been associated with efficient force production and minimal joint loading. However, the tool has yet to be examined scientifically. PURPOSE: The primary purpose of this investigation was to determine the inter-observer reliability for each node between two health care professionals (HCPs) that developed the OTSA, and secondarily to investigate the validity of the OTSA...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28537299/integration-of-systems-for-demonstrating-realistic-devices-general-discussion
#12
Leif Hammarström, Jose Martinez, Richard Cogdell, Kristine Rodulfo Tolod, Alexander Kibler, Haruo Inoue, Devens Gust, Flavia Cassiola, Daniel Nocera, Osamu Ishitani, Fabio Di Fonzo, Kazunari Domen, Tohru Setoyama, Akihiko Kudo
No abstract text is available yet for this article.
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28534894/biological-approaches-to-artificial-photosynthesis-fundamental-processes-and-theoretical-approaches-general-discussion
#13
Vincent Artero, Leif Hammarström, Fengtao Fan, Dong Ryeol Whang, Jose Martinez, Anthony Harriman, Takumi Noguchi, Joshua Karlsson, Peter Summers, Shigeru Itoh, Richard Cogdell, Alexander Kibler, Johannes Ehrmaier, Hitoshi Tamiaki, Etsuko Fujita, Seigo Shima, Shunya Yoshino, Haruo Inoue, Michael Wasielewski, Thomas Corry, Devens Gust, Flavia Cassiola, Hitoshi Ishida, Katsuhiko Takagi, Sang Ook Kang, Can Li, Licheng Sun, Hyunwoong Park, Hideki Hashimoto, Yutaka Amao, Eun Jin Son, Nobuo Kamiya, Jian-Ren Shen, Kizashi Yamaguchi
No abstract text is available yet for this article.
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28534593/molecular-catalysts-for-artificial-photosynthesis-general-discussion
#14
Mei Wang, Vincent Artero, Leif Hammarström, Jose Martinez, Joshua Karlsson, Devens Gust, Peter Summers, Charles Machan, Peter Brueggeller, Christopher D Windle, Yosuke Kageshima, Richard Cogdell, Kristine Rodulfo Tolod, Alexander Kibler, Dogukan Hazar Apaydin, Etsuko Fujita, Johannes Ehrmaier, Seigo Shima, Elizabeth Gibson, Ferdi Karadas, Anthony Harriman, Haruo Inoue, Akihiko Kudo, Tomoaki Takayama, Michael Wasielewski, Flavia Cassiola, Masayuki Yagi, Hitoshi Ishida, Federico Franco, Sang Ook Kang, Daniel Nocera, Can Li, Fabio Di Fonzo, Hyunwoong Park, Licheng Sun, Tohru Setoyama, Young Soo Kang, Osamu Ishitani, Jian-Ren Shen, Ho-Jin Son, Shigeyuki Masaoka
No abstract text is available yet for this article.
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28530749/inorganic-assembly-catalysts-for-artificial-photosynthesis-general-discussion
#15
Hiromu Kumagai, Leif Hammarström, Dong Ryeol Whang, Yuki Shinohara, Jose Martinez, Joshua Karlsson, Peter Summers, Christopher D Windle, Masanori Kodera, Richard Cogdell, Kristine Rodulfo Tolod, Dogukan Hazar Apaydin, Etsuko Fujita, Alexander Kibler, Fengtao Fan, Elizabeth A Gibson, Hisanao Usami, Akihide Iwase, Haruo Inoue, Akihiko Kudo, Devens Gust, Kazunari Domen, Flavia Cassiola, Katsuhiko Takagi, Sang Ook Kang, Akira Yamakata, Can Li, Licheng Sun, Hyunwoong Park, Young Soo Kang, Rengui Li, Fabio Di Fonzo, Tohru Setoyama, Osamu Ishitani
No abstract text is available yet for this article.
June 2, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28458036/a-heterologous-prime-boosting-strategy-with-replicating-vaccinia-virus-vectors-and-plant-produced-hiv-1-gag-dgp41-virus-like-particles
#16
Lydia R Meador, Sarah A Kessans, Jacquelyn Kilbourne, Karen V Kibler, Giuseppe Pantaleo, Mariano Esteban Roderiguez, Joseph N Blattman, Bertram L Jacobs, Tsafrir S Mor
Showing modest efficacy, the RV144 HIV-1 vaccine clinical trial utilized a non-replicating canarypox viral vector and a soluble gp120 protein boost. Here we built upon the RV144 strategy by developing a novel combination of a replicating, but highly-attenuated Vaccinia virus vector, NYVAC-KC, and plant-produced HIV-1 virus-like particles (VLPs). Both components contained the full-length Gag and a membrane anchored truncated gp41 presenting the membrane proximal external region with its conserved broadly neutralizing epitopes in the pre-fusion conformation...
July 2017: Virology
https://www.readbyqxmd.com/read/28405224/level-of-patient-physician-agreement-in-assessment-of-change-following-conservative-rehabilitation-for-shoulder-pain
#17
Stephanie D Moore-Reed, W Ben Kibler, Heather Bush, Tim L Uhl
BACKGROUND: Assessment of health-related status has been shown to vary between patients and physicians, although the degree of patient-physician discordance in the assessment of the change in status is unknown. METHODS: Ninety-nine patients with shoulder dysfunction underwent a standardized physician examination and completed several self-reported questionnaires. All patients were prescribed the same physical therapy intervention. Six weeks later, the patients returned to the physician, when self-report questionnaires were re-assessed and the Global Rating of Change (GROC) was completed by the patient...
April 2017: Shoulder & Elbow
https://www.readbyqxmd.com/read/28368344/the-combination-of-micro-diaphragm-pumps-and-flow-sensors-for-single-stroke-based-liquid-flow-control
#18
Christoph Jenke, Jaume Pallejà Rubio, Sebastian Kibler, Johannes Häfner, Martin Richter, Christoph Kutter
With the combination of micropumps and flow sensors, highly accurate and secure closed-loop controlled micro dosing systems for liquids are possible. Implementing a single stroke based control mode with piezoelectrically driven micro diaphragm pumps can provide a solution for dosing of volumes down to nanoliters or variable average flow rates in the range of nL/min to μL/min. However, sensor technologies feature a yet undetermined accuracy for measuring highly pulsatile micropump flow. Two miniaturizable in-line sensor types providing electrical readout-differential pressure based flow sensors and thermal calorimetric flow sensors-are evaluated for their suitability of combining them with mircopumps...
April 3, 2017: Sensors
https://www.readbyqxmd.com/read/28362752/far-detuned-cascaded-intermodal-four-wave-mixing-in-a-multimode-fiber
#19
R Dupiol, A Bendahmane, K Krupa, A Tonello, M Fabert, B Kibler, T Sylvestre, A Barthelemy, V Couderc, S Wabnitz, G Millot
We demonstrate far-detuned parametric frequency conversion processes in a few mode graded-index optical fibers pumped by a Q-switched picosecond laser at 1064 nm. Through a detailed analytical and numerical analysis, we show that the multiple sidebands are generated through a complex cascaded process involving inter-modal four-wave mixing. The resulting parametric wavelength detuning spans in the visible down to 405 nm and in the near-infrared up to 1355 nm.
April 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28335428/an-updated-review-of-ciguatera-fish-poisoning-clinical-epidemiological-environmental-and-public-health-management
#20
REVIEW
Melissa A Friedman, Mercedes Fernandez, Lorraine C Backer, Robert W Dickey, Jeffrey Bernstein, Kathleen Schrank, Steven Kibler, Wendy Stephan, Matthew O Gribble, Paul Bienfang, Robert E Bowen, Stacey Degrasse, Harold A Flores Quintana, Christopher R Loeffler, Richard Weisman, Donna Blythe, Elisa Berdalet, Ram Ayyar, Danielle Clarkson-Townsend, Karen Swajian, Ronald Benner, Tom Brewer, Lora E Fleming
Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts. The illness produces a complex array of gastrointestinal, neurological and neuropsychological, and cardiovascular symptoms, which may last days, weeks, or months. This paper is a general review of CFP including the human health effects of exposure to ciguatoxins (CTXs), diagnosis, human pathophysiology of CFP, treatment, detection of CTXs in fish, epidemiology of the illness, global dimensions, prevention, future directions, and recommendations for clinicians and patients...
March 14, 2017: Marine Drugs
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