keyword
MENU ▼
Read by QxMD icon Read
search

Kibler

keyword
https://www.readbyqxmd.com/read/28202751/superiority-in-rhesus-macaques-of-targeting-hiv-1-env-gp140-to-cd40-versus-lox-1-in-combination-with-replication-competent-nyvac-kc-for-induction-of-env-specific-antibody-and-t-cell-responses
#1
Gerard Zurawski, Xiaoying Shen, Sandra Zurawski, Georgia D Tomaras, David C Montefiori, Mario Roederer, Guido Ferrari, Christine Lacabaratz, Peter Klucar, Zhiqing Wang, Kathryn E Foulds, Shing-Fen Kao, Xuesong Yu, Alicia Sato, Nicole L Yates, Celia LaBranche, Sherry Stanfield-Oakley, Karen Kibler, Bertram Jacobs, Andres Salazar, Steve Self, Jimmy Fulp, Raphael Gottardo, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Giuseppe Pantaleo, Yves Levy
We compared the HIV-1-specific immune responses generated by targeting HIV-1 envelope protein (Env gp140) to either CD40 or LOX-1, two endocytic receptors on dendritic cells (DCs), in Rhesus macaques primed with a poxvirus vector (NYVAC-KC) expressing Env gp140. The DC-targeting vaccines, humanized recombinant monoclonal antibodies fused to Env gp140, were administered as a boost with poly ICLC adjuvant either alone or co-administered with the NYVAC-KC vector. All the DC-targeting vaccine administrations with poly ICLC increased the low-level serum anti-Env IgG responses elicited by NYVAC-KC priming significantly more (up to P =0...
February 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28179536/hiv-aids-vaccine-candidates-based-on-replication-competent-recombinant-poxvirus-nyvac-c-kc-expressing-trimeric-gp140-and-gag-derived-vlps-or-lacking-the-viral-molecule-b19-that-inhibits-type-i-interferon-activate-relevant-hiv-1-specific-b-and-t-cell-immune
#2
Juan García-Arriaza, Beatriz Perdiguero, Jonathan L Heeney, Michael S Seaman, David C Montefiori, Nicole L Yates, Georgia D Tomaras, Guido Ferrari, Kathryn E Foulds, Mario Roederer, Steven G Self, Bhavesh Borate, Raphael Gottardo, Sanjay Phogat, Jim Tartaglia, Susan W Barnett, Brian Burke, Anthony D Cristillo, Deborah E Weiss, Carter Lee, Karen V Kibler, Bertram L Jacobs, Ralf Wagner, Song Ding, Giuseppe Pantaleo, Mariano Esteban
The non-replicating attenuated poxvirus vector NYVAC expressing clade C(CN54) HIV-1 Env(gp120), Gag-Pol-Nef antigens (NYVAC-C) showed in phase I clinical trials limited immunogenicity. To enhance the capacity of the NYVAC vector to trigger broad humoral responses and a more balanced activation of CD4(+) and CD8(+) T cells, here we compared the HIV-1-specific immunogenicity elicited in non-human primates immunized with two replicating NYVAC vectors that have been modified by the insertion of K1L and C7L vaccinia viral host-range genes and express clade C(ZM96) trimeric HIV-1 gp140 protein or a Gag(ZM96)-Pol-Nef(CN54) polyprotein as Gag-derived virus-like particles (termed NYVAC-C-KC)...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28081085/coherent-and-incoherent-seeding-of-dissipative-modulation-instability-in-a-nonlinear-fiber-ring-cavity
#3
A Bendahmane, J Fatome, C Finot, G Millot, B Kibler
We investigate the coherent or incoherent seeding of dissipative modulation instability (MI) in a nonlinear fiber ring cavity. By varying wavelength and degree of coherence of the seed signal across the MI gain band, we observe a strong sensitivity of the resulting MI sidebands in terms of bandwidth and amplification. Both spectral and temporal characterizations are performed to reveal intensity coherence properties (over a single round-trip) of the generated temporal patterns. Experimental observations are well confirmed by numerical simulations...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28081084/tailoring-supercontinuum-generation-beyond-2%C3%A2-%C3%A2-%C3%AE-m-in-step-index-tellurite-fibers
#4
Clement Strutynski, Paul Froidevaux, Frédéric Désévédavy, Jean-Charles Jules, Grégory Gadret, Abdelkrim Bendahmane, Karol Tarnowski, Bertrand Kibler, Frédéric Smektala
We report numerical and experimental demonstrations of flexible group-velocity dispersion regimes in step-index tellurite fibers by fine control of the fiber core diameter. Our simple fiber design allowed us to explore various nonlinear propagation regimes beyond 2 μm, which involved careful control of four-wave mixing processes. Combined with the recent development of 2 μm fiber lasers, we present an easy way to tailor supercontinuum generation and related coherence features in the high-demand 1.5-3.5 μm spectral region...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28074349/second-generation-antipsychotic-utilization-and-metabolic-parameter-monitoring-in-an-inpatient-pediatric-population-a-retrospective-analysis
#5
Valerie D Nolt, Alexandra Victoria Kibler, G Lucy Wilkening, Tanya J Fabian
BACKGROUND: Second-generation antipsychotics (SGAs) are prescribed for a variety of indications and are strongly associated with adverse metabolic effects. Studies of pediatric outpatients have revealed several deficiencies in monitoring practices for adverse effects associated with SGAs. OBJECTIVE: Our objective was to characterize SGA prescribing and metabolic parameter monitoring (MPM) in an inpatient pediatric population. METHODS: Patients aged <18 years and discharged on SGA treatment between 1 November 2013 and 30 April 2014 from an inpatient psychiatric institution in Pittsburgh, PA, USA were included...
January 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/27932226/value-on-the-front-end-making-the-effective-diagnosis-for-optimal-treatment
#6
W Ben Kibler
Much effort is being made to quantitate and improve the outcomes associated with medical treatment. These outcomes are defined as how the patient did after an intervention and may be termed "value on the back end" of the treatment process. The diagnosis guides the content and timing of the treatment, and may be considered the "value on the front end" that optimizes the treatment process. The diagnosis can be defined as "that body of information, collected through the process of evaluating the patient's health problem, that determines the content and timing of the treatment of the health problem...
February 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27916706/the-influence-of-test-positions-on-clinical-assessment-for-scapular-dyskinesis
#7
Simin Deng, Kang Chen, Yanhong Ma, Juan Chen, Mi Huang
BACKGROUND: Appropriate evaluation of scapular dyskinesis is essential for therapeutic strategies. Although the current visual-based assessment is rapid and practical, the reliability of this method is unsatisfactory. It is necessary to adequately understand the conditions of assessment to maximize the benefit of therapeutic interventions. OBJECTIVE: To explore the influence of different test positions on clinical assessment for scapular dyskinesis. DESIGN: Observational study...
December 1, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27906213/multiple-four-wave-mixing-and-kerr-combs-in-a-bichromatically-pumped-nonlinear-fiber-ring-cavity
#8
D Ceoldo, A Bendahmane, J Fatome, G Millot, T Hansson, D Modotto, S Wabnitz, B Kibler
We report numerical and experimental studies of multiple four-wave mixing processes emerging from dual-frequency pumping of a passive nonlinear fiber ring cavity. We observe the formation of a periodic train of nearly background-free soliton pulses associated with Kerr frequency combs. The generation of resonant dispersive waves is also reported.
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27866794/treatment-of-symptomatic-acromioclavicular-joint-instability-by-a-docking-technique-clinical-indications-surgical-technique-and-outcomes
#9
W Ben Kibler, Aaron D Sciascia, Brent J Morris, David C Dome
PURPOSE: To report functional and objective outcomes resulting from surgical treatment of patients with symptomatic type III through V acromioclavicular (AC) joint injury by use of a modification of the anatomic AC joint reconstruction developed by Carofino and Mazzocca. METHODS: The study included all patients treated in 2009-2014 who presented with a history of direct trauma to the shoulder; deformity of the AC joint on clinical examination; radiographic findings that would classify the injury as a Rockwood type III, IV, or V injury; AC joint instability on clinical examination; and self-reported deficits of arm function on initial presentation, in whom a comprehensive and directed nonoperative program failed...
November 17, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27850825/1189-a-novel-approach-to-improve-guideline-adherence-in-pediatric-severe-traumatic-brain-injury
#10
Matthew Pesek, Nancy Jaimon, Craig Rusin, Kathleen Kibler, Ken Brady, Blaine Easley
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27755397/a-novel-electrocardiogram-algorithm-utilizing-st-segment-instability-for-detection-of-cardiopulmonary-arrest-in-single-ventricle-physiology-a-retrospective-study
#11
Eric L Vu, Craig G Rusin, Dan J Penny, Kathy K Kibler, Ronald Blaine Easley, Brendan Smith, Dean Andropoulos, Ken Brady
OBJECTIVE: We evaluated ST-segment monitoring to detect clinical decompensation in infants with single ventricle anatomy. We proposed a signal processing algorithm for ST-segment instability and hypothesized that instability is associated with cardiopulmonary arrests. DESIGN: Retrospective, observational study. SETTING: Tertiary children's hospital 21-bed cardiovascular ICU and 36-bed step-down unit. PATIENTS: Twenty single ventricle infants who received stage 1 palliation surgery between January 2013 and January 2014...
January 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27699112/continuous-cerebral-hemodynamic-measurement-during-deep-hypothermic-circulatory-arrest
#12
David R Busch, Craig G Rusin, Wanda Miller-Hance, Kathy Kibler, Wesley B Baker, Jeffrey S Heinle, Charles D Fraser, Arjun G Yodh, Daniel J Licht, Kenneth M Brady
While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement...
September 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27582990/scapular-dyskinesis-the-surgeon-s-perspective
#13
REVIEW
Simon J Roche, Lennard Funk, Aaron Sciascia, W Ben Kibler
The scapula fulfils many roles to facilitate optimal function of the shoulder. Normal function of the shoulder joint requires a scapula that can be properly aligned in multiple planes of motion of the upper extremity. Scapular dyskinesis, meaning abnormal motion of the scapula during shoulder movement, is a clinical finding commonly encountered by shoulder surgeons. It is best considered an impairment of optimal shoulder function. As such, it may be the underlying cause or the accompanying result of many forms of shoulder pain and dysfunction...
October 2015: Shoulder & Elbow
https://www.readbyqxmd.com/read/27572329/ehrlichia-chaffeensis-trp32-is-a-nucleomodulin-that-directly-regulates-expression-of-host-genes-governing-differentiation-and-proliferation
#14
Tierra R Farris, Paige S Dunphy, Bing Zhu, Clayton E Kibler, Jere W McBride
Ehrlichia chaffeensis is an obligately intracellular bacterium that reprograms the mononuclear phagocyte through diverse effector-host interactions to modulate numerous host cell processes, including transcription. In a previous study, we reported that E. chaffeensis TRP32, a type 1 secreted effector, interacts with multiple host nucleus-associated proteins and also auto-activates reporter gene expression in yeast. In this study, we demonstrate that TRP32 is a nucleomodulin that binds host DNA and alters host gene transcription...
August 29, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27467578/monkeypox-virus-induces-the-synthesis-of-less-dsrna-than-vaccinia-virus-and-is-more-resistant-to-the-anti-poxvirus-drug-ibt-than-vaccinia-virus
#15
William D Arndt, Stacy D White, Brian P Johnson, Trung Huynh, Jeffrey Liao, Heather Harrington, Samantha Cotsmire, Karen V Kibler, Jeffrey Langland, Bertram L Jacobs
Monkeypox virus (MPXV) infection fails to activate the host anti-viral protein, PKR, despite lacking a full-length homologue of the vaccinia virus (VACV) PKR inhibitor, E3. Since PKR can be activated by dsRNA produced during a viral infection, we have analyzed the accumulation of dsRNA in MPXV-infected cells. MPXV infection led to less accumulation of dsRNA than VACV infection. Because in VACV infections accumulation of abnormally low amounts of dsRNA is associated with mutations that lead to resistance to the anti-poxvirus drug isatin beta-thiosemicarbazone (IBT), we investigated the effects of treatment of MPXV-infected cells with IBT...
October 2016: Virology
https://www.readbyqxmd.com/read/27464202/von-willebrand-factor-multimers-during-transcatheter-aortic-valve-replacement
#16
Eric Van Belle, Antoine Rauch, Flavien Vincent, Emmanuel Robin, Marion Kibler, Julien Labreuche, Emmanuelle Jeanpierre, Marie Levade, Christopher Hurt, Natacha Rousse, Jean-Baptiste Dally, Nicolas Debry, Jean Dallongeville, Andre Vincentelli, Cedric Delhaye, Jean-Luc Auffray, Francis Juthier, Guillaume Schurtz, Gilles Lemesle, Thibault Caspar, Olivier Morel, Nicolas Dumonteil, Alain Duhamel, Camille Paris, Annabelle Dupont-Prado, Paulette Legendre, Frederic Mouquet, Berenice Marchant, Sylvie Hermoire, Delphine Corseaux, Karim Moussa, Aurelie Manchuelle, Jean-Jacques Bauchart, Valentin Loobuyck, Claudine Caron, Christophe Zawadzki, Fabrice Leroy, Jean-Christophe Bodart, Bart Staels, Jenny Goudemand, Peter J Lenting, Sophie Susen
BACKGROUND: Postprocedural aortic regurgitation occurs in 10 to 20% of patients undergoing transcatheter aortic-valve replacement (TAVR) for aortic stenosis. We hypothesized that assessment of defects in high-molecular-weight (HMW) multimers of von Willebrand factor or point-of-care assessment of hemostasis could be used to monitor aortic regurgitation during TAVR. METHODS: We enrolled 183 patients undergoing TAVR. Patients with aortic regurgitation after the initial implantation, as identified by means of transesophageal echocardiography, underwent additional balloon dilation to correct aortic regurgitation...
July 28, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27450551/cultural-assets-and-substance-use-among-hispanic-adolescents
#17
Mindy Ma, Lydia R Malcolm, Kristine Díaz-Albertini, Juan Carlos Sánchez, Brett Simpson, Lissette Cortes, Jeffrey L Kibler
Research on cultural factors and substance use among Hispanic adolescents has focused primarily on acculturation, while specific core Hispanic values and attributes have received minimal attention. The objective of the current study was to examine the relationship between traditional Hispanic cultural assets and substance use among adolescents. A purposive sample of 225 Hispanic adolescents (47% male) aged 13 to 16 years were recruited from community venues (e.g., park, school, mall) in a predominately Hispanic neighborhood...
July 21, 2016: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/27436005/modulation-instability-and-phase-shifted-fermi-pasta-ulam-recurrence
#18
O Kimmoun, H C Hsu, H Branger, M S Li, Y Y Chen, C Kharif, M Onorato, E J R Kelleher, B Kibler, N Akhmediev, A Chabchoub
Instabilities are common phenomena frequently observed in nature, sometimes leading to unexpected catastrophes and disasters in seemingly normal conditions. One prominent form of instability in a distributed system is its response to a harmonic modulation. Such instability has special names in various branches of physics and is generally known as modulation instability (MI). The MI leads to a growth-decay cycle of unstable waves and is therefore related to Fermi-Pasta-Ulam (FPU) recurrence since breather solutions of the nonlinear Schrödinger equation (NLSE) are known to accurately describe growth and decay of modulationally unstable waves in conservative systems...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27383159/repolarization-of-heart-ventricles-in-dogs-during-recovery-after-antiorthostatic-hypokinesia
#19
N A Kibler, S V Akhmetzianova, V P Nuzhny
Repolarization properties of ventricular myocardium were studied in anesthetized adult dogs of both sexes subjected to antiorthostatic hypokinesia (head-down tilt at 45° and 60° to the horizontal) and during recovery period (horizontal position for 15 min). The time of repolarization of ventricular myocardium during recovery surpassed the initial value, which represents an adaptive response of the heart to antiorthostasis.
June 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27370009/volume-based-interval-training-program-for-elite-tennis-players
#20
Natalie L Myers, Aaron D Sciascia, W Ben Kibler, Tim L Uhl
BACKGROUND: A sport-specific conditioning program can help tennis players train for competition or return to play from injury. This study determined the actual tennis serve volume in elite play and used these data to construct an interval training program based on stroke volume. HYPOTHESIS: There will be no differences in serve volume between male and female tennis players at the professional and junior levels. STUDY DESIGN: Retrospective cohort study...
July 1, 2016: Sports Health
keyword
keyword
14384
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"