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https://www.readbyqxmd.com/read/28731750/coupling-constant-corrections-in-a-holographic-model-of-heavy-ion-collisions
#1
Sašo Grozdanov, Wilke van der Schee
We initiate a holographic study of coupling-dependent heavy ion collisions by analyzing, for the first time, the effects of leading-order, inverse coupling constant corrections. In the dual description, this amounts to colliding gravitational shock waves in a theory with curvature-squared terms. We find that, at intermediate coupling, nuclei experience less stopping and have more energy deposited near the light cone. When the decreased coupling results in an 80% larger shear viscosity, the time at which hydrodynamics becomes a good description of the plasma created from high energy collisions increases by 25%...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28730481/label-free-phosphoproteomic-approach-for-kinase-signaling-analysis
#2
Edmund Wilkes, Pedro R Cutillas
Phosphoproteomics is a powerful platform for the unbiased profiling of kinase-driven signaling pathways. Quantitation of phosphorylation can be performed by means of either labeling or label-free mass spectrometry (MS) methods. Because of their simplicity and universality, label-free methodology is gaining acceptance and popularity in molecular biology research. Analytical workflows for label-free quantification of phosphorylation, however, need to overcome several hurdles for the technique to be accurate and precise...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28729784/discoloration-of-different-esthetic-restorative-materials-a-spectrophotometric-evaluation
#3
Matteo Ceci, Matteo Viola, Davide Rattalino, Riccardo Beltrami, Marco Colombo, Claudio Poggio
OBJECTIVE: A crucial property of esthetic restorative materials is their long-term color stability. The aim of this in vitro study was to evaluate the color stability of esthetic restorative materials (one microfilled flowable composite, one nanofilled composite, one nanoybrid composite, one microfilled composite, and one nanoybrid ormocer-based composite) after surface roughening with cola and exposure to different staining solutions (coffee and red wine). MATERIALS AND METHODS: All materials were polymerized into silicone rubber rings (2 mm × 6 mm × 8 mm) to obtain 150 specimens identical in size...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28729783/cytotoxic-evaluation-of-a-new-ceramic-based-root-canal-sealer-on-human-fibroblasts
#4
Sandra Chakar, Sylvie Changotade, Nada Osta, Issam Khalil
OBJECTIVES: The purpose of this study was to evaluate the cytotoxicity of a new bioceramic-based root canal sealer (BioMM) by direct and indirect contact with human fibroblasts and to compare it with a zinc oxide-eugenol sealer, the Pulp Canal Sealer-extended working time (PCS-EWT). MATERIALS AND METHODS: Cell viability was assessed through direct and indirect contact between human fibroblasts and sealer. Direct contact was performed at 24 h, whereas the indirect contact was performed at 24 and 48 h at different concentrations: 100%, 50%, and 25%...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28728602/robot-assisted-training-for-the-upper-limb-after-stroke-ratuls-study-protocol-for-a-randomised-controlled-trial
#5
Helen Rodgers, Lisa Shaw, Helen Bosomworth, Lydia Aird, Natasha Alvarado, Sreeman Andole, David L Cohen, Jesse Dawson, Janet Eyre, Tracy Finch, Gary A Ford, Jennifer Hislop, Steven Hogg, Denise Howel, Niall Hughes, Hermano Igo Krebs, Christopher Price, Lynn Rochester, Elaine Stamp, Laura Ternent, Duncan Turner, Luke Vale, Elizabeth Warburton, Frederike van Wijck, Scott Wilkes
BACKGROUND: Loss of arm function is a common and distressing consequence of stroke. We describe the protocol for a pragmatic, multicentre randomised controlled trial to determine whether robot-assisted training improves upper limb function following stroke. METHODS/DESIGN: Study design: a pragmatic, three-arm, multicentre randomised controlled trial, economic analysis and process evaluation. SETTING: NHS stroke services. PARTICIPANTS: adults with acute or chronic first-ever stroke (1 week to 5 years post stroke) causing moderate to severe upper limb functional limitation...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28725523/a-method-of-locating-the-dehiscence-during-middle-fossa-approach-for-superior-semicircular-canal-dehiscence-surgery
#6
Joel S Beckett, Lawrance K Chung, Carlito Lagman, Brittany L Voth, Cheng Hao Jacky Chen, Bilwaj Gaonkar, Quinton Gopen, Isaac Yang
Objectives  Superior semicircular canal dehiscence (SSCD) results from a defect in the middle cranial fossa floor. One challenge during SSCD repair is the lack of a consistent landmark. This study proposes a reference point above the external auditory canal at the level of the zygoma as the inferior craniectomy edge during surgery. Design  This is a retrospective review of patients with SSCD. Setting/Participants  A total of 72 cases of SSCD in 60 patients were repaired via a middle fossa approach at a single institution...
August 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28724881/effect-of-carotid-endarterectomy-on-retinal-function-in-asymptomatic-patients-with-hemodynamically-significant-carotid-artery-stenosis
#7
Anna Machalińska, Aleksandra Kowalska-Budek, Miłosz Piotr Kawa, Arkadiusz Kazimierczak, Krzysztof Safranow, Marta Kirkiewicz, Paweł Rynio, Grażyna Wilk, Wojciech Lubiński, Piotr Gutowski, Bogusław Machaliński
INTRODUCTION    The corrective effect of carotid endarterectomy (CEA) on disturbed ophthalmic artery flow in patients with a significant internal carotid artery stenosis (ICAS) presenting with ocular ischemic syndrome (i.e., symptomatic patients) is well established. However, no clear evidence exists regarding the efficacy of CEA for improvement of neuro-retinal function in patients without symptoms of ocular ischemic syndrome. OBJECTIVES    We determined the effects of CEA on retinal function in asymptomatic patients with hemodynamically significant internal carotid artery stenosis...
July 19, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28720189/enhancing-the-meaningfulness-of-work-for-astronauts-on-long-duration-space-exploration-missions
#8
Thomas W Britt, Anton Sytine, Ashley Brady, Russ Wilkes, Rebecca Pittman, Kristen Jennings, Kandice Goguen
INTRODUCTION: Numerous authors have identified the stressors likely to be encountered on long duration space exploration missions (e.g., to Mars), including the possibility of significant crises, separation from family, boredom/monotony, and interpersonal conflict. Although many authors have noted that meaningful work may be beneficial for astronauts on these missions, none have detailed the sources of meaningful work for astronauts and how these sources may differ between astronauts...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28719755/clinical-risk-factors-and-prognostic-model-for-primary-graft-dysfunction-after-lung-transplantation-in-patients-with-pulmonary-hypertension
#9
Mary K Porteous, James C Lee, David J Lederer, Scott M Palmer, Edward Cantu, Rupal J Shah, Scarlett L Bellamy, Vibha N Lama, Sangeeta M Bhorade, Maria M Crespo, John F McDyer, Keith M Wille, A Russell Localio, Jonathan B Orens, Pali D Shah, Ann B Weinacker, Selim Arcasoy, David S Wilkes, Lorraine B Ware, Jason D Christie, Steven M Kawut, Joshua M Diamond
RATIONALE: Pulmonary hypertension from pulmonary arterial hypertension or parenchymal lung disease is associated with an increased risk of primary graft dysfunction after lung transplantation. OBJECTIVE: We evaluated the clinical determinants of severe primary graft dysfunction in pulmonary hypertension and developed and validated a prognostic model. METHODS: We conducted a retrospective cohort study of patients in the multi-center Lung Transplant Outcomes Group with pulmonary hypertension at transplant listing...
July 18, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28717594/effect-of-freshwater-mussels-on-the-vertical-distribution-of-anaerobic-ammonia-oxidizers-and-other-nitrogen-transforming-microorganisms-in-upper-mississippi-river-sediment
#10
Ellen M Black, Michael S Chimenti, Craig L Just
Targeted qPCR and non-targeted amplicon sequencing of 16S rRNA genes within sediment layers identified the anaerobic ammonium oxidation (anammox) niche and characterized microbial community changes attributable to freshwater mussels. Anammox bacteria were normally distributed (Shapiro-Wilk normality test, W-statistic =0.954, p = 0.773) between 1 and 15 cm depth and were increased by a factor of 2.2 (p < 0.001) at 3 cm below the water-sediment interface when mussels were present. Amplicon sequencing of sediment at depths relevant to mussel burrowing (3 and 5 cm) showed that mussel presence reduced observed species richness (p = 0...
2017: PeerJ
https://www.readbyqxmd.com/read/28716897/mcpip1-downregulation-in-clear-cell-renal-cell-carcinoma-promotes-vascularization-and-metastatic-progression
#11
Paulina Marona, Judyta Górka, Zofia Mazurek, Waclaw Wilk, Janusz Rys, Marcin Majka, Jolanta Jura, Katarzyna Miekus
<p>Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and it forms highly vascularized tumors. The monocyte endoribonuclease MCPIP1 negatively regulates inflammation by degrading mRNA encoding proinflammatory cytokines, such as IL-6, IL-1 and IL-12. MCPIP1 is also a negative regulator of NFκB and AP1 activity and it influences a broad range of miRNA activities. Here we report that MCPIP1 protein levels are decreased during renal cancer progression. In patient-derived tumors, and xenografts established in NOD-SCID or nude mice, low MCPIP1 levels correlated strongly with increased proliferation, tumor outgrowth and vascularity...
July 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28716538/reliability-of-pelvic-floor-muscle-electromyography-tested-on-healthy-women-and-women-with-pelvic-floor-muscle-dysfunction
#12
Irene Koenig, Helena Luginbuehl, Lorenz Radlinger
OBJECTIVES: Electromyography (EMG) is a well-established method to quantify the relative pelvic floor muscle (PFM) activity. PFM EMG has shown good reliability in healthy women. However, its reliability has not been tested in women with PFM dysfunction. The reliability of EMG analysis methods concerning EMG normalization needs to be determined to assess specific therapeutic interventions. Therefore, the aim of this study was to investigate the intra-session reliability of PFM EMG variables by using 3 different analysis methods in women with PFM dysfunction...
July 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28713840/ultrafast-kinetics-of-linkage-isomerism-in-na2-fe-cn-5no-aqueous-solution-revealed-by-time-resolved-photoelectron-spectroscopy
#13
Azhr A Raheem, Martin Wilke, Mario Borgwardt, Nicholas Engel, Sergey I Bokarev, Gilbert Grell, Saadullah G Aziz, Oliver Kühn, Igor Yu Kiyan, Christoph Merschjann, Emad F Aziz
The kinetics of ultrafast photoinduced structural changes in linkage isomers is investigated using Na2[Fe(CN)5NO] as a model complex. The buildup of the metastable side-on configuration of the NO ligand, as well as the electronic energy levels of ground, excited, and metastable states, has been revealed by means of time-resolved extreme UV (XUV) photoelectron spectroscopy in aqueous solution, aided by theoretical calculations. Evidence of a short-lived intermediate state in the isomerization process and its nature are discussed, finding that the complete isomerization process occurs in less than 240 fs after photoexcitation...
July 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28713099/-giving-medico-legal-opinions-in-cases-with-suspicion-of-medical-mistake-part-1-between-medicine-and-justice
#14
Czesław Chowaniec, Małgorzata Chowaniec, Mateusz Wilk
Creating medico-legal opinion is a sophisticated investigative, analytical, decision-making and creative process. Forensic medicine specialist in cooperation with clinical medicine consultants, on the basis of evidence analysis, which was gathered during procedures and contained in the acts has to create an objective and essential opinion. This opinion is a vital, very important and irreplaceable proof in every case. Judicial body consults with forensic medicine specialist or specialists if there are circumstances for settlement of which there is a need of classified informations - art...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28713090/-the-teaching-of-medical-ethics-in-medical-school
#15
Mateusz Wilk, Tomasz Kirmes, Karolina Sypel, Izabela Paluch, Małgorzata Chowaniec, Czesław Chowaniec
Medical ethics constitutes some kind of core, which enables the physicians to decide in complicated clinical situations. This subject is taught during medical studies through only one semester. Number of teaching hours designed for this crucial in later physician's practice subject is insufficient. Additional problem in teaching process is inconsistence between the Law and the Code of Medical Ethics. As a result it causes alarmingly weak preparation of students to take practical decisions according to ethical and moral values of the Code of Medical Ethics...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712467/children-disassociate-from-antisocial-in-group-members
#16
Matti Wilks, Mark Nielsen
Extensive research has demonstrated that children show a robust in-group bias and, concurrently, are highly attuned to the prosocial and antisocial behavior of others. The limited research investigating the capacity for antisocial behavior to attenuate children's in-group bias has, however, returned mixed findings. Moreover, no research has examined how this might interact with perceived group permeability. Thus, the current study aimed to provide a more complete understanding of the relationship between in-group bias and antisocial behavior, how this interacts with perceptions of out-group behavior, and how group context (permeability) influences these responses...
July 13, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28708485/a-new-twist-in-measuring-mutation-rates
#17
Bartram L Smith, Claus O Wilke
The influenza virus mutates faster than we previously thought.
July 14, 2017: ELife
https://www.readbyqxmd.com/read/28706481/adverse-effects-of-the-apolipoprotein-e-%C3%AE%C2%B54-allele-on-episodic-memory-task-switching-and-gray-matter-volume-in-healthy-young-adults
#18
Jianfei Nao, Hongzan Sun, Qiushi Wang, Shuang Ma, Shuo Zhang, Xiaoyu Dong, Ying Ma, Xiaoming Wang, Dongming Zheng
Many studies have shown that healthy elderly subjects and patients with Alzheimer's disease (AD) who carry the apolipoprotein E (ApoE) ε4 allele have worse cognitive function and more severe brain atrophy than non-carriers. However, it remains unclear whether this ApoE polymorphism leads to changes of cognition and brain morphology in healthy young adults. In this study, we used an established model to measure verbal episodic memory and core executive function (EF) components (response inhibition, working memory and task switching) in 32 ApoE ε4 carriers and 40 non-carriers between 20 years and 40 years of age...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28706443/comparison-of-eq-5d-5l-health-state-utilities-using-four-country-specific-tariffs-on-a-breast-cancer-patient-sample-in-mainland-china
#19
Liu Liu, Shunping Li, Min Wang, Gang Chen
OBJECTIVE: The objective of this study was to compare the differences in the five-level EuroQol-5 dimensions (EQ-5D-5L) health state utility scores derived from Chinese, Japanese, Korean, and UK tariffs. METHODS: Six hundred and twenty-one breast cancer patients were invited for a face-to-face interview in Qingdao Municipal Hospital, China. EQ-5D-5L was scored using tariffs from China, Japan, Korea, and the UK. The null hypothesis of normal distribution of the EQ-5D-5L utility score was tested by the Shapiro-Wilk test...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28704830/sirtuins-in-skin-and-skin-cancers
#20
Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, Mary Ann Ndiaye, Christine Gaby Azer Philippe, Vijayasaradhi Setaluri, Nihal Ahmad
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases...
July 14, 2017: Skin Pharmacology and Physiology
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