keyword
MENU ▼
Read by QxMD icon Read
search

Wilk

keyword
https://www.readbyqxmd.com/read/28324390/evaluation-of-administered-dose-using-portal-images-in-craniospinal-irradiation-of-pediatric-patients
#1
Carina Marques Coelho, Raquel Calçada, Sofia Rodrigues, Juan Antonio Barragán, Ana Cravo Sá, Ana Paula Macedo, Maria de Fátima Monsanto
This study aimed to assess the administered dose based on portal imaging in craniospinal pediatric irradiation by evaluating cases in which portal images did or did not account for the total administered dose. We also intended to calculate the mean increase in total administered dose. Data were collected from General University Hospital Gregorio Marañón; we evaluated the total dose administered, total dose planned, number of portal images per treatment and corresponding monitor units of two different groups: one in which the dose from portal images is deducted from the total administered dose (D), and another in which it was not (N)...
March 21, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28302426/proximity-of-lateral-critical-structures-to-the-all-epiphyseal-outside-in-femoral-tunnels-in-pediatric-anterior-cruciate-ligament-reconstruction
#2
Mark K Lane, Jennifer Mutch, Kaitlyn Ratkowiak, Stephen E Lemos, Kunal Kalra
PURPOSE: To describe the proximity of the lateral critical structures (peroneal nerve [PN], popliteus tendon [PT], lateral collateral ligament [LCL], and articular cartilage [AC]) to the femoral tunnel for outside-in all-epiphyseal anterior cruciate ligament (ACL) reconstruction in reference to knee flexion angle. METHODS: All-epiphyseal ACL reconstructions were performed in 12 human cadaveric knees using arthroscopy and outside-in drilling for anatomic femoral tunnel placement that was ensured by identifying the center of the total ACL footprint...
March 13, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28301766/biophysical-models-of-protein-evolution-understanding-the-patterns-of-evolutionary-sequence-divergence
#3
Julian Echave, Claus O Wilke
For decades, rates of protein evolution have been interpreted in terms of the vague concept of functional importance. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models of protein evolution, which combine evolutionary theory with protein biophysics, have completely revolutionized our view of the forces that shape sequence divergence. Slowly evolving proteins have been found to evolve slowly because of selection against toxic misfolding and misinteractions, linking their rate of evolution primarily to their abundance...
March 15, 2017: Annual Review of Biophysics
https://www.readbyqxmd.com/read/28300539/interaction-of-dextran-derivatives-with-lipid-monolayers-and-the-consequential-modulation-of-the-film-properties
#4
Candelaria I Cámara, Natalia Wilke
Polysaccharides have been associated with various biological functions through their binding to membranes, but their specific role is still under debate. The aim of this work was to study the interaction of cationic and anionic polysaccharides with anionic and zwitterionic monolayers, at different subphase compositions, thus analyzing the influence of electrostatics on the interaction. The consequent effect of the polymer-lipid binding on the film properties was studied, with special interest in monolayer dynamics...
March 11, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28298403/assessment-of-burden-of-copd-abc-tool-perception-versus-evidence
#5
EDITORIAL
Sarah Houben-Wilke, Frits M E Franssen, Ineke Kok, Henk J Otten, Johan P Wempe, Jan H Vercoulen
No abstract text is available yet for this article.
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28294551/the-ignite-pharmacogenetics-working-group-an-opportunity-for-building-evidence-with-pharmacogenetic-implementation-in-a-real-world-setting
#6
REVIEW
L H Cavallari, A L Beitelshees, K V Blake, L G Dressler, J D Duarte, A Elsey, J N Eichmeyer, P E Empey, J P Franciosi, J K Hicks, A M Holmes, Ljb Jeng, C R Lee, J J Lima, N A Limdi, J Modlin, A O Obeng, N Petry, V M Pratt, T C Skaar, S Tuteja, D Voora, M Wagner, K W Weitzel, R A Wilke, J F Peterson, J A Johnson
No abstract text is available yet for this article.
March 14, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28289188/ligand-induced-allostery-in-the-interaction-of-the-pseudomonas-aeruginosa-heme-binding-protein-with-heme-oxygenase
#7
Daniel J Deredge, Weiliang Huang, Colleen Hui, Hirotoshi Matsumura, Zhi Yue, Pierre Moënne-Loccoz, Jana Shen, Patrick L Wintrode, Angela Wilks
A heme-dependent conformational rearrangement of the C-terminal domain of heme binding protein (PhuS) is required for interaction with the iron-regulated heme oxygenase (HemO). Herein, we further investigate the underlying mechanism of this conformational rearrangement and its implications for heme transfer via site-directed mutagenesis, resonance Raman (RR), hydrogen-deuterium exchange MS (HDX-MS) methods, and molecular dynamics (MD). HDX-MS revealed that the apo-PhuS C-terminal α6/α7/α8-helices are largely unstructured, whereas the apo-PhuS H212R variant showed an increase in structure within these regions...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28289126/putting-the-four-pillars-for-primary-care-physician-workforce-into-practice-locally
#8
Philip M Diller, Amanda Weidner, Michelle Roett, Allan Wilke, Ardis Davis
No abstract text is available yet for this article.
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28286669/long-term-complications-of-sulfur-mustard-poisoning-retinal-electrophysiological-assessment-in-40-severely-intoxicated-iranian-veterans
#9
Nasser Shoeibi, Mir Naghi Mousavi, Mahdi Balali-Mood, Mohammad Moshiri, Emadodin Darchini-Maragheh, Seyed Reza Mousavi, Mojtaba Abrishami
BACKGROUND: The eye is one of the most sensitive organs to sulfur mustard (SM) [C4H8Cl2S], and preliminary symptoms of exposure usually become evident in the eyes. In this study we aim to evaluate the possible long-term retinal electrophysiologic complications of SM poisoning in Iranian veterans during Iran-Iraq war (1980-1988). METHODS: In a cross-sectional study forty Iranian veterans who were exposed to mustard gas during the Iran-Iraq war (1980-1988) were included...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28285573/association-between-prior-vaginal-birth-after-cesarean-and-subsequent-labor-outcome
#10
Eyal Krispin, Liran Hiersch, Yulia Wilk Goldsher, Arnon Wiznitzer, Yariv Yogev, Eran Ashwal
OBJECTIVE: To estimate the effect of prior successful vaginal birth after cesarean (VBAC) on the rate of uterine rupture and delivery outcome in women undergoing labor after cesarean. METHODS: A retrospective cohort study of all women attempting labor after cesarean delivery in a university-affiliated tertiary-hospital (2007-2014). Study group included women attempting vaginal delivery with a history of cesarean delivery and at least one prior VBAC. Control group included women attempting first vaginal delivery following cesarean delivery...
March 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28283532/molecular-architecture-of-the-n-type-atpase-rotor-ring-from-burkholderia-pseudomallei
#11
Sarah Schulz, Martin Wilkes, Deryck J Mills, Werner Kühlbrandt, Thomas Meier
The genome of the highly infectious bacterium Burkholderia pseudomallei harbors an atp operon that encodes an N-type rotary ATPase, in addition to an operon for a regular F-type rotary ATPase. The molecular architecture of N-type ATPases is unknown and their biochemical properties and cellular functions are largely unexplored. We studied the B. pseudomallei N1No-type ATPase and investigated the structure and ion specificity of its membrane-embedded c-ring rotor by single-particle electron cryo-microscopy. Of several amphiphilic compounds tested for solubilizing the complex, the choice of the low-density, low-CMC detergent LDAO was optimal in terms of map quality and resolution...
March 10, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28282668/plasticity-during-early-brain-development-is-determined-by-ontogenetic-potential
#12
Ingeborg Krägeloh-Mann, Karen Lidzba, Marina A Pavlova, Marko Wilke, Martin Staudt
Two competing hypotheses address neuroplasticity during early brain development: the "Kennard principle" describes the compensatory capacities of the immature developing CNS as superior to those of the adult brain, whereas the "Hebb principle" argues that the young brain is especially sensitive to insults. We provide evidence that these principles are not mutually exclusive. Following early brain lesions that are unilateral, the brain can refer to homotopic areas of the healthy hemisphere. This potential for reorganization is unique to the young brain but available only when, during ontogenesis of brain development, these areas have been used for the functions addressed...
April 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28280649/first-case-of-foot-drop-associated-with-capecitabine-in-a-patient-with-thymidylate-synthase-polymorphism
#13
Andrew B Wilks, Muhammad W Saif
Capecitabine, an oral prodrug of 5-FU, has been approved by the FDA for use in patients with breast and colon cancers. In addition, capecitabine is commonly used in patients with other malignancies such as pancreatic, gastroesophageal, and hepatobiliary tract cancers. Though cerebellar toxicity is a rare but well-known side effect of intravenous 5-FU therapy, peripheral neuropathy with capecitabine has only been described in rare cases. In this case report, we describe a 79-year-old patient with locally advanced adenocarcinoma of the pancreas undergoing chemoradiation therapy with capecitabine who developed peripheral sensorimotor neuropathy...
January 24, 2017: Curēus
https://www.readbyqxmd.com/read/28279194/crispr-targeted-genome-editing-of-mesenchymal-stem-cell-derived-therapies-for-type-1-diabetes-a-path-to-clinical-success
#14
REVIEW
Dario Gerace, Rosetta Martiniello-Wilks, Najah Therese Nassif, Sara Lal, Raymond Steptoe, Ann Margaret Simpson
Due to their ease of isolation, differentiation capabilities, and immunomodulatory properties, the therapeutic potential of mesenchymal stem cells (MSCs) has been assessed in numerous pre-clinical and clinical settings. Currently, whole pancreas or islet transplantation is the only cure for people with type 1 diabetes (T1D) and, due to the autoimmune nature of the disease, MSCs have been utilised either natively or transdifferentiated into insulin-producing cells (IPCs) as an alternative treatment. However, the initial success in pre-clinical animal models has not translated into successful clinical outcomes...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28278261/evolutionary-and-biogeographical-implications-of-degraded-laglidadg-endonuclease-functionality-and-group-i-intron-occurrence-in-stony-corals-scleractinia-and-mushroom-corals-corallimorpharia
#15
Juan Sebastián Celis, David R Edgell, Björn Stelbrink, Daniel Wibberg, Torsten Hauffe, Jochen Blom, Jörn Kalinowski, Thomas Wilke
Group I introns and homing endonuclease genes (HEGs) are mobile genetic elements, capable of invading target sequences in intron-less genomes. LAGLIDADG HEGs are the largest family of endonucleases, playing a key role in the mobility of group I introns in a process known as 'homing'. Group I introns and HEGs are rare in metazoans, and can be mainly found inserted in the COXI gene of some sponges and cnidarians, including stony corals (Scleractinia) and mushroom corals (Corallimorpharia). Vertical and horizontal intron transfer mechanisms have been proposed as explanations for intron occurrence in cnidarians...
2017: PloS One
https://www.readbyqxmd.com/read/28277016/the-correlates-of-physical-activity-among-adult-m%C3%A3-tis
#16
Christopher J Ryan, Martin Cooke, Sharon I Kirkpatrick, Scott T Leatherdale, Piotr Wilk
OBJECTIVES: Métis, with a population of close to 390,000 people, are a culturally distinct and constitutionally recognized Aboriginal group in Canada that suffers from poorer overall health than non-Aboriginal Canadians. One important predictor of good health is physical activity. Guided by frameworks based on social and Aboriginal-specific determinants, we investigated the correlates of leisure-time physical activity (LTPA) and active transportation (walking) among adult Métis, with a particular focus on how culturally specific variables were associated with these two types of activity...
February 28, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28276483/vascular-transcriptome-profiling-identifies-sphingosine-kinase-1-as-a-modulator-of-angiotensin-ii-induced-vascular-dysfunction
#17
Mateusz Siedlinski, Ryszard Nosalski, Piotr Szczepaniak, Agnieszka H Ludwig-Gałęzowska, Tomasz Mikołajczyk, Magdalena Filip, Grzegorz Osmenda, Grzegorz Wilk, Michał Nowak, Paweł Wołkow, Tomasz J Guzik
Vascular dysfunction is an important phenomenon in hypertension. We hypothesized that angiotensin II (AngII) affects transcriptome in the vasculature in a region-specific manner, which may help to identify genes related to vascular dysfunction in AngII-induced hypertension. Mesenteric artery and aortic transcriptome was profiled using Illumina WG-6v2.0 chip in control and AngII infused (490 ng/kg/min) hypertensive mice. Gene set enrichment and leading edge analyses identified Sphingosine kinase 1 (Sphk1) in the highest number of pathways affected by AngII...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275931/the-concentration-of-vanadium-in-pathologically-altered-human-kidneys
#18
Aleksandra Wilk, Barbara Wiszniewska, Dagmara Szypulska-Koziarska, Paulina Kaczmarek, Maciej Romanowski, Jacek Różański, Marcin Słojewski, Kazimierz Ciechanowski, Małgorzata Marchelek-Myśliwiec, Elżbieta Kalisińska
Vanadium has a unique and beneficial effect on both humans and animal organisms; however, excessive amount of the above-mentioned metal can cause many alterations in tissues and organs, including the kidneys. The aim of the study was to determine the concentration of vanadium (V) in the kidneys removed from patients due to lesions of various etiologies, including the rejection of the transplanted kidneys. Additionally, we determined the influence of selected biological and environmental factors on the V concentration...
March 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28275348/cerebromatic-a-versatile-toolbox-for-spline-based-mri-template-creation
#19
Marko Wilke, Mekibib Altaye, Scott K Holland
Brain image spatial normalization and tissue segmentation rely on prior tissue probability maps. Appropriately selecting these tissue maps becomes particularly important when investigating "unusual" populations, such as young children or elderly subjects. When creating such priors, the disadvantage of applying more deformation must be weighed against the benefit of achieving a crisper image. We have previously suggested that statistically modeling demographic variables, instead of simply averaging images, is advantageous...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28274273/acute-effects-of-foam-rolling-on-passive-tissue-stiffness-and-fascial-sliding-study-protocol-for-a-randomized-controlled-trial
#20
Frieder Krause, Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried Banzer
BACKGROUND: Self-myofascial release (SMR) aims to mimic the effects of manual therapy and tackle dysfunctions of the skeletal muscle and connective tissue. It has been shown to induce improvements in flexibility, but the underlying mechanisms are still poorly understood. In addition to neuronal mechanisms, improved flexibility may be driven by acute morphological adaptations, such as a reduction in passive tissue stiffness or improved movement between fascial layers. The aim of the intended study is to evaluate the acute effects of SMR on the passive tissue stiffness of the anterior thigh muscles and the sliding properties of the associated fasciae...
March 9, 2017: Trials
keyword
keyword
14382
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"