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https://www.readbyqxmd.com/read/29442695/enhancing-upconversion-from-nayf%C3%A2-yb-er-nayf%C3%A2-core-shell-nanoparticles-assembled-on-metallic-nanostructures
#1
Qi Luo, Xueshuang Deng, Wenhan Chen, Hai Guo, Wei Ou-Yang, Xiaohong Chen, Sumei Huang
We report a simple method for the fabrication of a three-layered plasmonic structure of silicon substrate-Au nanospheres-upconversion particles (UCNPs) that displays up to 101-fold fluorescence enhancement. Monodispersed pure hexagonal-phase NaYF4:Yb,Er core and NaYF4:Yb,Er@NaYF4 core@shell nanocrystals were prepared by a solvothermal method. Two dimensional (2D) assembled Au spheres were prepared on a Si substrate, and then, 2D arrays of UCNPs were deposited on the grown 2D monolayered Au spheres by a self-organizing process...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29433643/prevalence-and-clinical-outcomes-of-heterotopic-ossification-after-ulnar-collateral-ligament-reconstruction
#2
Jin-Young Park, Beom Ho Seo, Kyung-Ho Hong, Jae-Hyung Lee, Kyung-Soo Oh, Seok Won Chung, Young-Min Noh
BACKGROUND: Ulnar collateral ligament (UCL) reconstruction has become increasingly popular in elite athletes. However, the prevalence of heterotopic ossification (HO) formation after UCL reconstruction has not yet been reported. We sought to determine the prevalence of HO formation after UCL reconstruction and the clinical outcomes following HO treatment. MATERIALS AND METHODS: From October 2005 to April 2014, 179 patients underwent primary UCL reconstruction. Of the 179 patients, 161 with a minimum of 2 years of follow-up were retrospectively reviewed to evaluate HO formation and clinical outcomes...
March 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29431989/folate-conjugated-polyphosphoester-with-reversible-cross-linkage-and-reduction-sensitivity-for-drug-delivery
#3
Youwen Cao, Jinlin He, Jie Liu, Mingzu Zhang, Peihong Ni
To improve the therapeutic efficacy and circulation stability in vivo, we synthesized a new kind of drug delivery carrier based on folic acid-conjugated polyphosphoester via the combined reactions of Michael addition polymerization and esteri-fication. The produced amphiphilic polymer, abbreviated as P(EAEP-AP)-LA-FA, could self-assemble into nanoparticles (NPs) with core-shell structure in water and reversible core cross-linked by lipoyl groups. Using the core cross-linked FA-conjugated nanoparticles (CCL-FA NPs) to encapsulate hydrophobic anticancer drug doxorubicin (DOX), we studied the stability of NPs, in vitro drug release, cellular uptake and targeting intracellular release, compared with both uncross-linked FA-conjugated nanoparticles (UCL-FA NPs) and core cross-linked nanoparticles without FA-conjugated (CCL NPs)...
February 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29415751/when-participants-get-involved-reconsidering-patient-and-public-involvement-in-clinical-trials-at-the-mrc-clinical-trials-unit-at-ucl
#4
Claire L Vale, William J Cragg, Ben Cromarty, Bec Hanley, Annabelle South, Richard Stephens, Kate Sturgeon, Mitzy Gafos
BACKGROUND: Patient and public involvement (PPI) in clinical trials aims to ensure that research is carried out collaboratively with patients and/or members of the public. However, current guidance on involving clinical trial participants in PPI activities is not consistent. METHODS: We reviewed the concept of participant involvement, based on our experience. Two workshops were held at the MRCCTU at UCL with the aim of defining participant involvement, considering its rationale; benefits and challenges; and identifying appropriate models for participant involvement in clinical trials...
February 7, 2018: Trials
https://www.readbyqxmd.com/read/29394469/glutathione-mediated-size-tunable-ucnps-pt-iv-znfe2-o4-nanocomposite-for-multiple-bioimaging-guided-synergetic-therapy
#5
Huiting Bi, Yunlu Dai, Piaoping Yang, Jiating Xu, Dan Yang, Shili Gai, Fei He, Bin Liu, Chongna Zhong, Guanghui An, Jun Lin
Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)-platinum(IV) (Pt(IV))-ZnFe2 O4 , denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near-infrared light can convert low energy photons to high energy ones, which act as the UV-vis source to simultaneously mediate the PDT effect and Fenton's reaction of ZnFe2 O4 nanoparticles. Meanwhile, the Pt(IV) prodrugs can be reduced to high virulent Pt(II) by glutathione in the cancer cells, which can bond to DNA and inhibit the copy of DNA...
February 2, 2018: Small
https://www.readbyqxmd.com/read/29384083/combining-optical-coherence-tomography-with-visual-field-data-to-rapidly-detect-disease-progression-in-glaucoma-a-diagnostic-accuracy-study
#6
David F Garway-Heath, Haogang Zhu, Qian Cheng, Katy Morgan, Chris Frost, David P Crabb, Tuan-Anh Ho, Yannis Agiomyrgiannakis
BACKGROUND: Progressive optic nerve damage in glaucoma results in vision loss, quantifiable with visual field (VF) testing. VF measurements are, however, highly variable, making identification of worsening vision ('progression') challenging. Glaucomatous optic nerve damage can also be measured with imaging techniques such as optical coherence tomography (OCT). OBJECTIVE: To compare statistical methods that combine VF and OCT data with VF-only methods to establish whether or not these allow (1) more rapid identification of glaucoma progression and (2) shorter or smaller clinical trials...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29354418/elbow-ulnar-collateral-ligament-reconstruction-using-a-4-strand-docking-plus-technique
#7
Benjamin F Donohue, Marc G Lubitz, Timothy E Kremchek
The "Docking Plus" technique for elbow ulnar collateral ligament (UCL) surgery is described in the following text and video. Depite the general success of UCL surgery, significant rates of retear and failure of return to competition persist. Hypothesized reasons for UCL surgery failure include insufficient graft strength (midsubstance tears), insufficient graft tensioning (functional UCL insufficiency, valgus extension overload), and insufficient healing of graft to bone (proximal avulsions). This technique is meant to incorporate the best aspects of the previously described techniques for UCL reconstruction to create a larger, stronger, better-tensioned graft with a larger healing surface area to bone, a lower retear rate, and a lower risk of complications...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29353422/biomechanical-in-vitro-comparison-of-suture-anchors-for-thumb-ucl-repair
#8
M Wagner, W Schmoelz, H Stofferin, R Arora
Different types of intraosseous suture anchors can be used for thumb ulnar collateral ligament (UCL) repair surgery. Some of them have already been tested biomechanically in intact bone; however, there exists little knowledge of their stability when implanted in avulsion fracture. In this biomechanical in vitro study, three anchor types (hard, soft and novel BoneWelding) were tested on 24 fresh frozen human thumbs from 12 body donors. After the repair of an iatrogenic ligamentous UCL rupture, the thumbs were cyclically loaded...
January 20, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29353376/injury-prevention-in-baseball-from-youth-to-the-pros
#9
REVIEW
Heath P Melugin, Nels D Leafblad, Christopher L Camp, Stan Conte
PURPOSE OF REVIEW: This review examines recent literature on injury epidemiology and prevention in the sport of baseball from youth to professional levels. RECENT FINDINGS: Overuse is the predominant mechanism of injury in youth baseball players. Newer stretching and exercise protocols may help prevent these injuries. At the professional level, however, overuse has not been proven to correlate with increased injury incidence, but pitch counts are still monitored...
January 20, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29335854/nonreconstruction-options-for-treating-medial-ulnar-collateral-ligament-injuries-of-the-elbow-in-overhead-athletes
#10
REVIEW
Nicholas J Clark, Vishal S Desai, Joshua D Dines, Mark E Morrey, Christopher L Camp
PURPOSE OF REVIEW: This review aims to describe the nonreconstructive options for treating ulnar collateral ligament (UCL) injuries ranging from nonoperative measures, including physical therapy and biologic injections, to ligament repair with and without augmentation. RECENT FINDINGS: Nonoperative options for UCL injuries include guided physical therapy and biologic augmentation with platelet-rich plasma (PRP). In some patients, repair of the UCL has shown promising return to sport rates by using modern suture and suture anchor techniques...
January 15, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29330041/acute-epileptiform-activity-induced-by-gabazine-involves-proteasomal-rather-than-lysosomal-degradation-of-kca2-2-channels
#11
Steffen Müller, Xiati Guli, Judith Hey, Anne Einsle, Daniela Pfanz, Victor Sudmann, Timo Kirschstein, Rüdiger Köhling
Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In the acute in vitro epilepsy model induced in hippocampal brain slice preparations by exposure to the GABAA receptor blocker gabazine (GZ), the AHP was previously shown to be significantly decreased. Here, we asked the question whether KCa2...
January 9, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29327008/an-upconversion-nanoparticle-based-fluorescence-resonance-energy-transfer-system-for-effectively-sensing-caspase-3-activity
#12
Lin Liu, Hua Zhang, Daqian Song, Zhenxin Wang
We report a new fluorescence resonance energy transfer (FRET) sensing platform for the sensitive detection of caspase-3 activity in vitro and in cells using NaGdF4:Yb3+,Er3+@NaGdF4 upconversion nanoparticles (UCNPs) as the energy donor and Rhodamine B (RB) as the energy acceptor. The phosphorylated RB-modified peptide containing a caspase-3 cleavage site and cell-penetrating peptide (CPP) motif (sequence, (RB)-DEVDGGS(p)GCGT(p)GRKKRRQRRRPQ) is immobilized on the UCNP surface via the strong coordination interaction between Gd3+ ions with phosphate...
January 12, 2018: Analyst
https://www.readbyqxmd.com/read/29326958/performance-and-return-to-sport-after-thumb-ulnar-collateral-ligament-repair-in-major-league-baseball-players
#13
Robert A Jack, Kyle R Sochacki, Bryce Gagliano, David M Lintner, Joshua D Harris, Patrick C McCulloch
Background: Acute ruptures of the ulnar collateral ligament (UCL) of the thumb are common injuries in sports. Surgical repair has yielded excellent results and high return-to-sport (RTS) rates in elite athletes. Purpose: To determine (1) the RTS rate in Major League Baseball (MLB) players following thumb UCL repair, (2) postoperative career length and games played per season, (3) pre- and postoperative performance, (4) postoperative performance compared with matched control players, and (5) whether dominant and nondominant hand injuries respond differently...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29325512/an-industry-update-the-latest-developments-in-therapeutic-delivery
#14
Oliver C Steinbach
The present industry update covers the period 1 October-31 October 2017, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. While the corporate news in October was traditionally dominated by the announcement of the third quarter results, with most of them showing market and revenue growth but also an increasing number of initial public offerings after years of slower financial development, we also saw trends continuing toward an increasing number of convergences of drugs with nanotechnology, devices and 21st century information technology...
February 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29322208/the-association-of-the-medial-joint-vacuum-phenomenon-with-ulnar-collateral-ligament-injury-in-symptomatic-elbows-of-younger-athletes
#15
Ryan Tai, Tyson Bolinske, Varand Ghazikhanian, Jacob C Mandell
OBJECTIVE: To determine the prevalence of intra-articular gas (IAG) on elbow radiography and evaluate variables, including IAG, as predictors of UCL injury. MATERIALS AND METHODS: This IRB-approved retrospective study consisted of 241 consecutive elbow radiographic studies containing AP radiographs with valgus stress of both symptomatic and asymptomatic sides in 234 patients. The IAG, medial joint space (MJS), and MJS difference between the symptomatic and asymptomatic elbow (MJSD) were evaluated by two readers, as well as patient age, gender, sport played, and handedness...
January 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29315453/a-partial-posterior-bundle-ulnar-collateral-ligament-tear-in-a-10-year-old-boy
#16
Todd P Pierce, Jennifer Kurowicki, Kimona Issa, Anthony Festa, Vincent K McInerney, Anthony J Scillia
Medial-sided elbow pain is becoming more common among pediatric overhead sport athletes. One potential cause of this is a partial or complete tear of the ulnar collateral ligament (UCL). Because the growth plate remains open in many of these athletes, the most common injury experienced is an avulsion at the medial epicondyle. However, although rare, there is a potential to tear the UCL, with the most common tears occurring at the anterior bundle. However, tears to the posterior bundle are quite rare in pediatric patients...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29305267/on-lenses-and-blind-spots-in-qualitative-exercise-and-environment-research-a-response-to-stephanie-coen
#17
Russell Hitchings, Alan Latham, Ucl
Qualitative research focused on how people experience the social and material environments in which they exercise has the potential to inform public health agendas in all sorts of ways. This commentary takes up the claim made by Stephanie Coen that such research should begin with an 'equity lens' and place a greater emphasis on 'critique' than we did in the 'Exercise and Environment' special issue to which she responds. At its best qualitative research reveals new ways of thinking about the social and material contexts at hand...
January 2, 2018: Health & Place
https://www.readbyqxmd.com/read/29302668/near-infrared-optical-and-x-ray-computed-tomography-dual-modal-imaging-probe-based-on-novel-lanthanide-doped-k0-3bi0-7f2-4-upconversion-nanoparticles
#18
Ran An, Pengpeng Lei, Peng Zhang, Xia Xu, Jing Feng, Hongjie Zhang
A novel K0.3Bi0.7F2.4 upconversion (UC) matrix has been prepared successfully by a solvothermal method. K0.3Bi0.7F2.4:Yb3+/Ln3+ (Ln = Er, Ho, Tm) upconversion nanoparticles (UCNPs) show a corresponding excellent upconversion luminescence (UCL) under 980 nm laser irradiation. Especially, the strong near-infrared (NIR) UCL of K0.3Bi0.7F2.4:20% Yb3+/0.5% Tm3+ (abbreviated as BYT) UCNPs is suitable for deep tissue optical imaging. Moreover, the high X-ray absorption coefficient of Bi makes the as-prepared UCNPs favorable for computed tomography (CT) imaging...
January 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29260178/highly-luminescent-eu-sm-mn-doped-cas-up-down-conversion-nano-particles-application-to-ultra-sensitive-latent-fingerprint-detection-and-in-vivo-bioimaging
#19
Jikai Wang, Ni He, Yanli Zhu, Zhengbin An, Ping Chen, Craig A Grimes, Zhou Nie, Qingyun Cai
Due to their unique properties, rare-earth doped upconversion luminescence (UCL) nanomaterials are of considerable scientific interest. Meanwhile, alkaline-earth sulfide materials based on a completely different electron trapping (ET) mechanism demonstrate extremely high UCL efficiencies, which are several dozens of times more than those of conventional fluoride UCL nanomaterials. However, the large particle size, easy hydrolysis, and difficulty in achieving uniform dispersion have precluded bioassay applications...
December 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29243750/strong-up-conversion-luminescence-of-rare-earth-doped-oxide-films-enhanced-by-gap-modes-on-zno-nanowires
#20
Jinlei Wu, Baosheng Cao, Luis Rino, Yurui Fang, Li Hu, Zhenyi Zhang, Yingzhou Huang, Bin Dong
Up-conversion luminescence (UCL) from rare-earth doped oxide (RE) films has great potential for application in fields such as solar cells, bioanalysis, or display technologies. However, the relatively high phonon energy of oxide matrices usually facilitates nonradiative relaxation leading to low UCL efficiency. Herein, we report a three-layer hierarchical structure of Ag/ZnO nanowires (nw-ZnO)/RE composite films, which enhances the UCL of rare-earth doped oxide films. An optimization of the geometric structure of the composite films demonstrated an increase of UCL by up to almost two orders of magnitude in Er3+ and Tm3+ doped YbMoO4 films...
December 15, 2017: Nanoscale
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