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Kenichiro Yamamura, Yasuo Takatsu, Toshiaki Miyati
In acoustic-stimulated functional magnetic resonance imaging (fMRI), tasks are performed by subjects either during imaging in the presence of scanning noise or during non-imaging periods without scanning noise. Suitable syllables for voice tasks performed with MRI-compatible headphones are limited during the imaging period with scanning noise. However, suitable syllables for voice tasks during the non-imaging period, without scanning noise, are not yet known. This study aimed to identify suitable syllables for voice tasks during both imaging and non-imaging periods...
December 4, 2017: Radiological Physics and Technology
Hui Li, Lei Xu, Guanying Chen
The ability to synthesize upconversion nanocrystals (UCNCs) with tailored upconversion luminescence and controlled size is of great importance for biophotonic applications. However, until now, limited success has been met to prepare bright, ultrasmall, and monodispersed β-NaYF₄:Yb3+/Er3+ UCNCs. In this work, we report on a synthetic method to produce monodisperse hexagonal NaYF₄:Yb3+/Er3+ nanocrystals of ultrasmall size (5.4 nm) through a precise control of the reaction temperature and the ratio of Na⁺/Ln3+/F-...
December 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Feifei Zhao, Dongguang Yin, Chenglong Wu, Bingqi Liu, Tao Chen, Mengting Guo, Kexian Huang, Zhiwen Chen, Yong Zhang
Lanthanide-doped upconversion nanoparticles (UCNPs) have shown potential applications in diverse fields. However, their upconversion luminescence (UCL) intensity and excitation wavelength range are limited by the weak and narrowband absorption of lanthanide ions. Herein, we introduce and validate a strategy to largely increase the absorptivity and upconversion luminescence intensity under 808 nm excitation by broadband dye-sensitized quenching-shield sandwich structured upconversion nanocrystals NaLuF4:Gd,Yb,Tm@NaLuF4:Gd,Yb@NaNdF4:Yb...
November 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Ganesh N Pundkar, Satish B Sonar, Omkar P Kulkarni
Introduction: Old neglected posterior type of elbow dislocations is not very common and generally requires open reduction. It was usually treated with open reduction and K-wire stabilization. We did a newer method in which in addition cruciate type ligament reconstruction; we have reconstructed lateral ulnar collateral ligament (LUCL) and UCL (medial collateral ligament) using semitendinosus graft. This allowed extra stability and early mobilization of the elbow joint. Authors report 3-month-old neglected posterior type of elbow dislocation without any fracture...
July 2017: Journal of Orthopaedic Case Reports
Zhengwen Yang, Jianzhi Yang, Jianbei Qiu, Zhiguo Song
Comprehensive investigations of near infrared (NIR) downshift and visible upconversion luminescence (UCL) mechanisms were carried out for Yb3+ single-doped and Er3+,Yb3+ co-doped SiO2 inverse opals under excitation at 256, 378, 520 and 980 nm. NIR emission at 976 nm from the Yb3+-O2- charge transfer state and UCL emission at 500 nm due to the cooperative emission of two Yb3+ ions were observed in SiO2:Yb3+ inverse opal upon excitation at 256 and 980 nm, respectively. The cooperative UCL of two Yb3+ ions was suppressed due to the photon trap created by the photonic band gap...
November 27, 2017: Physical Chemistry Chemical Physics: PCCP
Ji-Hye Han, Joong Yeon Won, Sung Kwang Hong, Ja Hee Kim, Eun Soo Kim, Hyung-Jong Kim, Hyo-Jeong Lee
At present, there is no objective method for diagnosing subjective sensorineural tinnitus. Recently, the acoustic change complex (ACC) has been used to evaluate neural detection of sounds. Thus, the present study aimed to examine whether the ACC can reflect cortical detection and discrimination of sounds matched with tinnitus frequencies. We hypothesized that the ACC to change stimuli matched with tinnitus frequencies would be decreased in tinnitus patients because the tinnitus interferes with the perception of acoustic changes...
2017: PloS One
M Beck, A Wichelhaus, T Mittlmeier
OBJECTIVE: Restoration of ulnar elbow stability in cases of posttraumatic and chronic ulnar ligament instability. INDICATIONS: Symptomatic therapy-resistant ulnar ligament instability of the elbow. CONTRAINDICATIONS: Arthrofibrosis and high-grade elbow arthrosis. SURGICAL TECHNIQUE: Anatomical reconstruction of the ulnar collateral ligament (UCL) with autologous tendon graft (tendons of the palmaris longus muscle and gracilis muscle) in implant-free docking technique...
November 20, 2017: Operative Orthopädie und Traumatologie
M D Tran, V A Rakov
Synchronized high-speed (124 or 210 kiloframes per second) video images and wideband electromagnetic field records of the attachment process were obtained for 4 negative strokes in natural lightning at the Lightning Observatory in Gainesville, Florida. The majority of imaged upward connecting leaders (UCLs) and upward unconnected leaders, inferred to be mostly initiated from trees, exhibited a pulsating behavior (brightening/fading cycles). UCLs, whose maximum extent ranged from 11 to 25 m, propagated in virgin air at speeds ranging from 1...
November 17, 2017: Scientific Reports
Ana Lozano, Samanta Uclés, Ana Uclés, Carmen Ferrer, Amadeo R Fernández-Alba
This paper presents an efficiency evaluation of GC coupled with quadrupole Orbitrap MS for identification andquantitation in the multiresidue pesticide analysis of baby foods in full-scan mode. The identification criteria were studied following SANTE guidelines (retention time, mass accuracy, and ion ratio), comfortably complying with the values established, even at 0.003 mg/kg. Method validation was carried out on 15 selected GC-amenable pesticides covered by Commission Directive No. 2006/125/EC in three different baby food matrixes...
November 15, 2017: Journal of AOAC International
Elena Hakme, Ana Lozano, Samanta Uclés, Amadeo R Fernández-Alba
Nowadays, the control of pesticide residues in food is well established. The capacity of triple quadrupole technology to satisfy the current food regulations has been demonstrated. However, the permanent high demand of consumers for more sensitive and faster testing is driving the development of improved analytical methodologies that increase the performances of sensitivity and robustness and reduce the analysis time. In this work, the feasibility of decreasing the run time to 12.4 min by modifying the oven temperature program, for a multiresidue method covering 203 pesticides, was evaluated...
November 14, 2017: Analytical and Bioanalytical Chemistry
Adam Mead
Dr Mead earned his medical degree from the University of Oxford and trained in hematology at St Bartholomew's Hospital and University College London. In 2007, he earned his PhD at UCL, which focused on the analysis of FLT3 mutations in acute myeloid leukemia. He is now Associate Professor of Hematology and MRC Senior Clinical Fellow at the WIMM, University of Oxford. His research group focuses on myeloid diseases and normal blood stem-cell biology. Dr Mead is the lead clinician for myeloproliferative neoplasms (MPN) and chronic myeloid leukemia in the Thames Valley Strategic Clinical Network and is the chief investigator for several chronic myeloid leukemia and MPN clinical trials...
November 10, 2017: Future Oncology
Jennifer J Beck, Connor G Richmond, Marc A Tompkins, Ann Heyer, Kevin G Shea, Aristides I Cruz
BACKGROUND: Sports injuries are common in pediatric and adolescent patients and the evaluation and treatment of these injuries continues to evolve. The purpose of this review is to provide a comprehensive appraisal of the most recent literature, highlighting updates on sports-related upper extremity injuries in pediatric patients. METHODS: An electronic search of the PubMed, EMBASE, and Google Scholar databases was performed for keywords related to pediatric overhead athletes, osteochondritis dissecans (OCD) of the capitellum, medial epicondyle fractures, shoulder instability, and clavicle fractures...
November 7, 2017: Journal of Pediatric Orthopedics
Tony Lewis, Ian Sillitoe, Natalie Dawson, Su Datt Lam, Tristan Clarke, David Lee, Christine Orengo, Jonathan Lees
Gene3D ( is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains...
November 3, 2017: Nucleic Acids Research
C Groves, A Whiteman, G Kumar, R Stephens, D Walker
Perioperative medicine is an emerging specialty aimed at improving outcomes in the high-risk surgical population. The authors set out to characterize the demographics and determine the motivation of 'early adopters' of this specialty by retrospectively reviewing the application forms of students enrolled on the UCL Perioperative Medicine Masters Programme. A total of 139 applications were reviewed. The median age of applicants was 35 years; 81% were UK based, with the remainder from a worldwide distribution...
November 2, 2017: British Journal of Hospital Medicine
Elena Zapata-Arriaza, Francisco Moniche, Pardo-Galiana Blanca, Alejandro Bustamante, Irene Escudero-Martínez, Oscar Uclés, Ángela Ollero-Ortiz, Jose Antonio Sánchez-García, Miguel Ángel Gamero, Ángeles Quesada, Diana Vidal De Francisco, Mercedes Romera, Carlos De la Cruz, Gema Sanz, Joan Montaner
BACKGROUND: The Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN), Age, Atrial Fibrillation, Dysphagia, male sex, and National Institutes of Health Stroke Scale (A2DS2), and acute ischemic stroke-associated pneumonia score (AIS-APS) scores were created to predict stroke-associated pneumonia (SAP), one of the most important medical stroke complications. External validation of all such scores in an acute stroke population was the aim of our study. METHODS: Patients with ischemic or hemorrhagic stroke were prospectively enrolled in the multicenter Stroke-Induced Pneumonia in Andalucía project between October 2014 and May 2016...
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Ning Kang, Chao-Chao Ai, Ya-Ming Zhou, Zuo Wang, Lei Ren
A novel strategy for preparing highly pure NaYF4 based upconversion nanoparticles (UCNPs) was developed using lanthanide oleate compounds [Ln(OA)3] as precursors, denoted as Ln-OA preparation method. Comparing with the conventional solvothermal method for synthesizing UCNPs using lanthanide chloride compound (LnCl3) as precursors (denoted as Ln-Cl method), Ln-OA strategy exhibited the merits of high purity, less purification process, uniform size and enhanced upconversion luminescence (UCL) intensity in preparing core and core-shell UCNPs excited by 980 nm or 808 nm near infrared (NIR) laser...
October 30, 2017: Nanotechnology
Lili Feng, Fei He, Yunlu Dai, Shili Gai, Chongna Zhong, Chunxia Li, Piaoping Yang
Photodynamic therapy (PDT) is a novel technique that has been extensively employed in cancer treatment; it utilizes reactive oxygen species to kill malignant cells. However, poor performance of the photosensitizer itself, limited penetration depth and the overexpression of glutathione (GSH) in cancer cells are the major obstacles facing the actual clinical application of PDT. Inspired by the challenges mentioned above, here we propose multifunctional nanoparticles utilizing mesoporous manganese silicate (MnSiO3)-coated upconversion nanoparticles (UCNPs) as nanocarriers for loading highly fluorescent graphitic-phase carbon nitride quantum dots (g-C3N4 QDs) to simultaneously act as a photosensitive drug and imaging agent...
October 25, 2017: Biomaterials Science
Alex Campbell, Carolina Restrepo, Gaurav Deshpande, Sarah M Bernstein, Caroline Tredway, Lisa Wendby, Bjorn Schonmeyr
BACKGROUND: Severity of the primary unilateral cleft lip/nose deformity (UCL/N) is postulated to play a key role in postoperative complications, aesthetic result, and need for secondary surgery. There is no validated and widely accepted classification scheme of initial cleft severity. The purpose of this study was to validate the Unilateral Cleft Lip Cleft Severity Index as a reliable tool for evaluating presurgical UCL/N deformity by both surgeons and laypersons. METHODS: Twenty-five participants (10 surgeons and 15 laypeople) evaluated 25 sets of randomly selected presurgical standardized photographs of UCL/N patients...
September 2017: Plastic and Reconstructive Surgery. Global Open
Alex Campbell, Carolina Restrepo, Gaurav Deshpande, Caroline Tredway, Sarah M Bernstein, Rachel Patzer, Lisa Wendby, Bjorn Schonmeyr
BACKGROUND: A standardized evaluation tool is needed for the assessment of surgical outcomes in cleft lip surgery. Current scales for evaluating unilateral cleft lip/nose (UCL/N) aesthetic outcomes are limited in their reliability, ease of use, and application. The Unilateral Cleft Lip Surgical Outcomes Evaluation (UCL SOE) scale measures symmetry of 4 components and sums these for a total score. The purpose of this study was to validate the SOE as a reliable tool for use by both surgeons and laypersons...
September 2017: Plastic and Reconstructive Surgery. Global Open
Danyi Zhu, Xiunan Fang, Calvin Eiber, James Avery, David Holder, Alistair McEwan
Electrical Impedance Tomography has been recently applied to image fast neural activity in the somatosensory cerebral cortex. This non-invasive imaging modality has the unique advantage of high spatial-temporal resolution in millimeters over milliseconds. This work was designed to test an existing 32-channel EIT system, a modified UCL ScouseTom, and to discuss the feasibility of imaging neural activity in retinal tissue through computer simulation. The finite element method was used to model a retinal slice with a realistic conductivity-depth profile of the macaque eye...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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