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Wei Tang, Shixiang Wan, Zhen Yang, Andrew E Teschendorff, Quan Zou
Motivation: A clear identification of the primary site of tumor is of great importance to the next targeted site-specific treatments and could efficiently improve patient's overall survival. Even though many classifiers based on gene expression had been proposed to predict the tumor primary, only a few studies focus on using DNA methylation profiles to develop classifiers, and none of them compares the performance of classifiers based on different profiles. Results: We introduced novel selection strategies to identify highly tissue-specific CpG sites and then used the random forest approach to construct the classifiers to predict the origin of tumors...
September 28, 2017: Bioinformatics
Jie Zhou, Lingchang Meng, Chong Sun, Weiran Ye, Chengqun Chen, Bin Du
In order to prevent the aggregation of ICG and enhance its stability, a novel nanoplatform (TiO2:Yb,Ho,F-β-CD@ICG/HA) was designed for NIR-induced phototherapy along with multi-mode imaging(UCL/MRI/Flu). In this nanosysytem: TiO2:Yb,Ho,F was used as upconversion materials and applied in vivo for the first time; β-CD was acted as a "protective umbrella" to load separated ICG and avoid the low phototherapy efficiency because of its aggregation; HA was the capping agent of β-CD to prevent ICG unexpected leaking and a target to recognize CD44 receptor...
October 6, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Baoling Duan, Wuping Zhang, Haixia Zheng, Chunyan Wu, Qiang Zhang, Yushan Bu
Abstract: To compare the human health risk of heavy metals and As in sewage sludge between adults and children, samples were collected from five wastewater treatment plants (WWTPs) located in the urban district of Taiyuan, the capital of Shanxi. Heavy metals and As in sewage sludge can be ranked according to the mean concentration in the following order: Cu > Cr > Zn > Pb > As > Hg > Cd. Compared with the concentration limit set by different countries, the heavy metals contents in sewage sludge were all within the standard limits, except for the content of As, which was higher than the threshold limit established by Canada...
October 8, 2017: International Journal of Environmental Research and Public Health
Shenghua Y Sinkler, Steven S Segal
In response to exercise, vasodilatation initiated within the microcirculation of skeletal muscle ascends the resistance network into upstream feed arteries (FAs) located external to the tissue. Ascending vasodilatation (AVD) is essential to reducing FA resistance that otherwise restricts blood flow into the microcirculation. We tested the hypothesis that signalling events underlying AVD vary with the intensity and duration of muscle contraction. In the gluteus maximus muscle of anaesthetized male C57BL/6 mice (age, 3-4 months), brief tetanic contraction (100 Hz, 500 ms) evoked rapid onset vasodilatation (ROV) in FAs that peaked within 4 s...
October 5, 2017: Journal of Physiology
Nigel Hawkes
No abstract text is available yet for this article.
October 3, 2017: BMJ: British Medical Journal
Tom Northey, Anja Barešic, Andrew C R Martin
Motivation: Protein-protein interactions are vital for protein function with the average protein having between three and ten interacting partners. Knowledge of precise protein-protein interfaces comes from crystal structures deposited in the Protein Data Bank (PDB), but only 50% of structures in the PDB are complexes. There is therefore a need to predict protein-protein interfaces in silico and various methods for this purpose. Here we explore the use of a predictor based on structural features and which exploits random forest machine learning, comparing its performance with a number of popular established methods...
September 18, 2017: Bioinformatics
He Wang, Mengchao Li, Ze Yin, Tianxiang Zhang, Xu Chen, Donglei Zhou, Jinyang Zhu, Wen Xu, Haining Cui, Hongwei Song
High brightness of upconversion luminescence (UCL) for a thinner layer of UC nanoparticles is significant for routine applications of effective trademark anticounterfeiting technology. In this work, efficient UCL of NaYF4:Yb(3+),Er(3+)/Tm(3+) was realized by combining a Ta2O5 dielectric layer on the cyclical island silver films supported by poly(methyl methacrylate) opal photonic crystals (PCs). The synergistic modulation of localized surface plasmon resonance and PC effect results in a significant improvement of the local electromagnetic field and an optimum UC enhancement of 145 folds...
October 11, 2017: ACS Applied Materials & Interfaces
Mehmet Tekman, Alan Medlar, Monika Mozere, Robert Kleta, Horia Stanescu
Motivation: Haplotype reconstruction is an important tool for understanding the aetiology of human disease. Haplotyping infers the most likely phase of observed genotypes conditional on constraints imposed by the genotypes of other pedigree members. The results of haplotype reconstruction, when visualised appropriately, show which alleles are identical by descent despite the presence of untyped individuals. When used in concert with linkage analysis, haplotyping can help delineate a locus of interest and provide a succinct explanation for the transmission of the trait locus...
August 14, 2017: Bioinformatics
Yuan Tian, Tiffany J Morris, Amy P Webster, Zhen Yang, Stephan Beck, Andrew Feber, Andrew E Teschendorff
Summary: The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell-type heterogeneity, network analysis, and a series of interactive graphical user interfaces...
August 14, 2017: Bioinformatics
Jingting Sui, Guixia Liu, Yan Song, Dan Li, Xiangting Dong, Jinxian Wang, Wensheng Yu
Multifunctional nanocomposites (NCs) incorporating magnetic, luminescent and photothermal conversion properties are endowed with potential application in many fields such as imaging, tumor detection, drug delivery and therapy. Here, multifunctional MWCNTs-NaGdF4:Yb(3+), Er(3+), Eu(3+) NCs, which offer the potential for integrated bioimaging and photothermal therapy (PTT) were fabricated by a facile hydrothermal method. The resulting sample exhibits uniform morphology, bright dual-modal luminescence and intrinsic paramagnetic properties...
September 22, 2017: Journal of Colloid and Interface Science
Daniel J Hurwit, Grant H Garcia, Joseph Liu, David W Altchek, Anthony Romeo, Joshua Dines
BACKGROUND: Amid evidence that the number of ulnar collateral ligament (UCL) reconstructions performed annually is on the rise, there continues to be significant variation among surgeons in the management of UCL injuries. The purpose of this paper was to survey the members of the American Shoulder and Elbow Surgeons (ASES) to assess current trends related to the comprehensive treatment of athletes presenting with UCL injury. METHODS: An online survey was distributed to the active members of the ASES...
September 20, 2017: Journal of Shoulder and Elbow Surgery
Arthur E Poropat, Mark A S Laidlaw, Bruce Lanphear, Andrew Ball, Howard W Mielke
BACKGROUND: Multiple cross-sectional studies suggest that there is an association between blood lead and preeclampsia. OBJECTIVES: We performed a systematic review and meta-analysis to summarize information on the association between preeclampsia and lead poisoning. METHODS: Searches of Medline, Web of Science, Scopus, Pubmed, Science Direct and ProQuest (dissertations and theses) identified 2089 reports, 46 of which were downloaded after reviewing the abstracts, and 11 studies were evaluated as meeting the selection criteria...
September 19, 2017: Environmental Research
Wilaiporn Graisuwan, Songchan Puthong, Hui Zhao, Suda Kiatkamjornwong, Patrick Theato, Voravee P Hoven
Thermo-responsive and active functional fiber mats were prepared from random copolymer of poly(pentafluorophenyl acrylate-co-N-isopropylacrylamide) (P(PFPA-co-NIPAM)), which was synthesized by a controlled radical polymerization process based on reversible addition-fragmentation chain transfer (RAFT). As reactive sites, pentafluorophenyl ester (PFP) groups were incorporated in the copolymer to allow for a multiple post-polymerization modification. UV-crosslinkable moieties were first introduced by partially reacting PFP groups in the copolymer with ortho-nitrobenzyl (ONB)-protected diamine...
September 20, 2017: Biomacromolecules
Donglei Zhou, Dongyu Li, Xiangyu Zhou, Wen Xu, Xu Chen, Dali Liu, Yongsheng Zhu, Hongwei Song
The ability to modulate the intensity of electromagnetic field by semiconductor plasmon nanoparticles is becoming attractive due to its unique doping-induced local surface plasmon resonance (LSPR) effect that is different from metals. Herein, we synthesized mCu2-xS@SiO2@Y2O3:Yb(3+)/Er(3+) core-shell composites and experimentally and theoretically studied the semiconductor plasmon induced up-conversion enhancement and obtained 30-fold up-conversion enhancement compared with that of SiO2@Y2O3:Yb(3+)/Er(3+) composites...
October 11, 2017: ACS Applied Materials & Interfaces
Jin-Ping Zhang, Yang Yu, Yan-Zhao Feng, Yan-Fei Zhou, Fan Zhang, Yu-Wei Yang, Meng-Qi Lei, Yu-Chan Zhang, Yue-Qin Chen
Increasing grain yield is the most important subject of crop breeding. Here, we report the elevated expression of a conserved microRNA, OsmiR408, could positively regulate grain yield in rice by increasing panicle branches and grain number. We further showed that OsmiR408 regulates grain yield by downregulating its downstream target, OsUCL8, which is an uclacyanin (UCL) gene of the phytocyanin family. The knock down or knock out of OsUCL8 also increases grain yield, while the overexpression of OsUCL8 results in an opposite phenotype...
September 13, 2017: Plant Physiology
Anthony F De Giacomo, Steven S Shin
One of the most commonly injured structures of the thumb metacarpophalangeal (MCP) joint is the ulnar collateral ligament (UCL). An acute injury of this ligament is often amenable to primary repair. Despite the favorable outcomes of primary repair, the thumb is often restricted during initial healing of the ligament with immobilization and delayed rehabilitation. We present a novel technique to augment the repair of the UCL with suture tape to provide immediate biomechanical support and strength during the critical time of ligament healing...
September 8, 2017: Techniques in Hand & Upper Extremity Surgery
Evgenia I Tolstykh, Marina O Degteva, Alexandra V Vozilova, Lynn R Anspaugh
The method of fluorescence in situ hybridization (FISH) applied to peripheral blood T lymphocytes is used for retrospective dose estimation, and the results obtained from the analysis of stable chromosomal aberrations are usually interpreted as a dose accumulated in the red bone marrow (RBM). However, after local internal exposure of the RBM, doses derived from FISH were found to be lower than those derived from direct measurements of radionuclides accumulated in the bodies of exposed persons. These results were obtained for people residing near the Techa River contaminated by (89,90)Sr (beta-emitters) in 1949-1956 (Chelyabinsk Oblast, Russia)...
September 9, 2017: Radiation and Environmental Biophysics
Lucie Voulhoux, Gérald Cremer, Anne Spinewine, Marie de Saint-Hubert, Fabienne Amant, Carine Sohy, Didier Schoevaerdts
The objectives of the study are to determine the prevalence and potential risk factors of misuse of respiratory inhalers among hospitalized patients admitted at the CHU UcL Namur, site Godinne. Using a cross-sectional design, patients using respiratory inhalers since more than 7 days were recruited from a database established by the hospital pharmacy. Inhaler technique was assessed using a standardised check-list and graded misuse as major or minor errors using previously published criteria. Demographic and clinical data were prospectively collected using standardised tools...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
Jonathan D F Wadsworth, Gary Adamson, Susan Joiner, Lara Brock, Caroline Powell, Jacqueline M Linehan, Jonathan A Beck, Sebastian Brandner, Simon Mead, John Collinge
Human prion diseases are associated with a range of clinical presentations, and they are classified by both clinicopathological syndrome and etiology, with subclassification according to molecular criteria. Here, we describe updated procedures that are currently used within the MRC Prion Unit at UCL to determine a molecular diagnosis of human prion disease. Sequencing of the PRNP open reading frame to establish the presence of pathogenic mutations is described, together with detailed methods for immunoblot or immunohistochemical determination of the presence of abnormal prion protein in the brain or peripheral tissues...
2017: Methods in Molecular Biology
Joseph A Gil, Alison Chambers, Kalpit N Shah, Joseph J Crisco, Christopher Got, Edward Akelman
BACKGROUND: A complete thumb ulnar collateral ligament (UCL) repaired with 1-suture anchor has been demonstrated to be significantly weaker compared with the intact UCL. The objective of this study is to test the biomechanical strength of a 2-anchor thumb UCL repair. METHODS: Nine paired fresh-frozen hands were used for this biomechanical analysis. One thumb from each pair was randomized to the control group and one to the repair group. In the control group, the UCL was loaded to failure in tension...
August 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
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