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Hongling Deng, Sa Huang, Chen Xu
Nowadays, in order to improve the diagnostic accuracy of the disease, more and more contrast agents have been applied in the clinical imaging modalities. A combination of nanotechnology with optical, computed X-ray tomography (CT), and magnetic resonance imaging (MRI) has great potential to improve disease diagnosis and therapy. Herein, we developed a novel multimodal contrast agent for deep-tissue bioimaging based on PEGylated Mn2+ doped NaLuF4 :Yb/Er nanoparticles (PEG-UCNPs). The multimodal nanoprobes have revealed the intensely red upconversion luminescence emission for deep-tissue upconversion luminescence (UCL) imaging...
July 1, 2018: Talanta
John Conibear, Brendan Chia, Yenting Ngai, Andrew Tom Bates, Nicholas Counsell, Rushil Patel, David Eaton, Corinne Faivre-Finn, John Fenwick, Martin Forster, Gerard G Hanna, Susan Harden, Philip Mayles, Syed Moinuddin, David Landau
INTRODUCTION: Following growing evidence to support the safety, local control (LC) and potential improvement in overall survival (OS) in patients with oligometastatic non-small cell lung cancer (NSCLC) that have been treated with local ablative therapy such as stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS), we initiate the SARON trial to investigate the impact and feasibility of adding SABR/SRS and radical radiotherapy (RRT) following standard chemotherapy on OS...
April 17, 2018: BMJ Open
Veronika Moslerová, Martina Dadáková, Ján Dupej, Eva Hoffmannova, Jiří Borský, Miloš Černý, Přemysl Bejda, Karolína Kočandrlová, Jana Velemínská
OBJECTIVES: To evaluate facial asymmetry changes in pre-school patients with orofacial clefts after neonatal cheiloplasty and to compare facial asymmetry with age-matched healthy controls. METHODS AND MATERIALS: The sample consisted of patients with unilateral cleft lip (UCL), unilateral cleft lip and palate (UCLP), and bilateral cleft lip and palate (BCLP). The patients were divided in two age groups with a mean age of 3 years (n = 51) and 4.5 years (n = 45), respectively, and 78 age-matched individuals as controls...
May 2018: International Journal of Pediatric Otorhinolaryngology
Robert A Jack, Matthew B Burn, Kyle R Sochacki, Patrick C McCulloch, David M Lintner, Joshua D Harris
BACKGROUND: The anterior bundle of the medial ulnar collateral ligament (UCL) is the primary restraint to valgus stress at the elbow and is often injured among overhead throwing athletes. Despite prevention strategies, injuries to the elbow UCL are on the rise. PURPOSE: To determine (1) the return-to-sport (RTS) rate of Major League Baseball (MLB) position players after elbow medial UCL reconstruction, (2) postoperative career length and games per season, (3) pre- and postoperative performance, (4) postoperative performance versus matched control players, and (5) whether position players changed positions after UCL reconstruction...
March 1, 2018: American Journal of Sports Medicine
Christopher L Camp, Stan Conte, John D'Angelo, Stephen A Fealy
BACKGROUND: Although much as been done to characterize trends of medial ulnar collateral ligament (UCL) reconstruction in pitchers, outcomes in position players (PPs) (non-pitchers) remain undefined in the current literature. METHODS: Three resources were combined to identify all known Major League Baseball and Minor League Baseball (MiLB) PPs who have ever undergone UCL reconstruction. A multitude of player and surgical variables were included. Trends over time were analyzed collectively, based on level of play, revision status (primary vs revision), and position...
March 23, 2018: Journal of Shoulder and Elbow Surgery
Yong Han, Yanli An, Gang Jia, Xihui Wang, Chen He, Yinan Ding, Qiusha Tang
Hepatocellular carcinoma (HCC) is frequently metastatic once diagnosed and less likely to respond to curative surgery, emphasizing the need for the development of more sensitive and effective diagnostic and therapeutic strategies. Epithelial cell adhesion molecule (EpCAM) is deemed as the biomarker of cancer stem cells (CSCs), which are mainly responsible for the recurrence, metastasis and prognosis of HCC. In this study, we discuss the use of mitoxantrone (MX), an antitumor drug and a photosensitizer, for designing upconversion nanoparticle-based micelles grafted with the anti-EpCAM antibody, for dual-modality magnetic resonance/upconversion luminescence (MR/UCL)-guided synergetic chemotherapy and photodynamic therapy (PDT)...
March 23, 2018: Nanoscale
Lucía Lebrato Hernández, María Díaz Sánchez, María Prieto León, Nuria Alicia Cerdá Fuertes, Antonio José Uclés Sánchez, José Luis Casado Chocán
OBJECTIVES: Multiple sclerosis (MS) is the most common chronic disabling disease of the central nervous system (CNS) in young adults. It is characterized by the presence of multiple demyelinating inflammatory lesions disseminated in the CNS. Pseudotumoral lesions (PL) are rarely observed in patients with MS. METHODS: These atypical lesions can pose a diagnostic problem, especially when they are present at disease onset. RESULTS: Most MS patients with PLs only have a single episode throughout their disease course, which reflects its low tendency of recurrence...
March 9, 2018: Multiple Sclerosis and related Disorders
David P Trofa, Joseph M Lombardi, Manish S Noticewala, Christopher S Ahmad
Reconstruction of the ulnar collateral ligament (UCL) remains the gold standard for treating overhead throwing athletes with valgus instability secondary to UCL pathology. Although surgical techniques for reconstruction have evolved over time, current methods allow 90% of patients to return to their preinjury level of activity. Despite encouraging results with reconstruction, UCL repair remains a valuable treatment option for patients with UCL pathology fitting specific criteria. There are a number of advantages associated with a direct repair, and further, the development of collagen-coated sutures for ligament repair augmentation makes this procedure an attractive surgical option under the correct circumstances...
January 2018: Arthroscopy Techniques
Steven S Shin, Carola F van Eck, Carlos Uquillas
PURPOSE: This study aimed to evaluate and compare the biomechanical strength of repair of the thumb ulnar collateral ligament (UCL) alone and repair augmented with suture tape. METHODS: Twelve fresh-frozen cadaveric specimens (6 matched pairs) had the UCL divided at its attachment on the base of the proximal phalanx and repaired with or without suture tape augmentation. A material testing machine was used to provide valgus stress at a rate of 0.1 mm/s until failure...
March 15, 2018: Journal of Hand Surgery
Friedrich C Jassil, Alisia Carnemolla, Helen Kingett, Bruce Paton, Aidan G O'Keeffe, Jacqueline Doyle, Stephen Morris, Neville Lewis, Amy Kirk, Andrea Pucci, Kusuma Chaiyasoot, Rachel L Batterham
INTRODUCTION: Roux-en-Y gastric bypass and sleeve gastrectomy are the two most common bariatric surgery performed in the UK that result in comparable weight loss and remission of obesity-associated comorbidities. However, there is a paucity of studies examining the impact of these procedures on body composition, physical activity levels, sedentary behaviour, physical function and strength, dietary intake, health-related quality of life and costs. METHODS AND ANALYSIS: The BARI-LIFESTYLE observational study is a 1-year prospective, longitudinal cohort study within a real-world routine clinical care setting aiming to recruit 100 patients with severe obesity undergoing either primary Roux-en-Y gastric bypass or sleeve gastrectomy from two bariatric centres in London, UK...
March 16, 2018: BMJ Open
Christopher L Camp, Stan Conte, John D'Angelo, Stephen A Fealy, Christopher S Ahmad
BACKGROUND: In recent years, there has been a dramatic rise in the annual number of ulnar collateral ligament (UCL) reconstructions performed in amateur baseball pitchers. Accordingly, increasing numbers of players are entering professional baseball having already undergone the procedure; however, the effect of prior UCL reconstruction on future success remains unknown. PURPOSE: (1) To provide an epidemiologic report on baseball players who undergo UCL reconstruction before being selected in the Major League Baseball (MLB) Draft, (2) to define the outcomes in terms of statistical performance, and (3) to compare these results with those of matched controls (ie, non-UCL reconstruction)...
March 1, 2018: American Journal of Sports Medicine
Christopher Looze, Eric Strauss, Laith Jazrawi
Shoulder and elbow injuries have been described in baseball players as early as the 1940s. Ulnar collateral ligament (UCL) tears have been recognized as a significant source of disability for baseball players and have been seen in increasing frequency as training regimens and level of play have become more intense and rigorous. Our understanding and treatment of these injuries have also evolved over time. This article summarizes the evolution of the treatment of UCL tears and discusses future directions for the treatment and prevention of these injuries...
March 2018: Bulletin of the Hospital for Joint Diseases
Adekunle M Adetayo, Olutayo James, Wasiu L Adeyemo, Mobolanle O Ogunlewe, Azeez Butali
Objectives: The unilateral cleft lip (UCL) repair technique has evolved extensively over the past century into its modern form and has been identified as an important determinant of treatment outcome. The aim of this study was to evaluate and compare treatment outcomes following repair of UCL using either the Tennison-Randall (triangular) technique or the Millard rotation-advancement technique. Materials and Methods: This was a prospective randomized controlled study conducted at the Lagos University Teaching Hospital between January 2013 and July 2014...
February 2018: Journal of the Korean Association of Oral and Maxillofacial Surgeons
S Louryan
Trained in the ULB, pupil of Albert Brachet, Ernest Van Campenhout frequented successively the Université Libre de Bruxelles (ULB), the Yale University and the Montreal University, to settle definitively in the Université Catholique de Louvain (UCL), where he becomes professor of anatomy, histology and embryology. Despite the fact that his most interest was the autonomic innervation of the digestive tract, he examined a lot of problems, and his severe and rigorous teaching impressed a number of student's generations...
2018: Revue Médicale de Bruxelles
N L O'Brien, A Fiorentino, D Curtis, C Rayner, C Petrosellini, M Al Eissa, N J Bass, A McQuillin, S I Sharp
Recent results imply that rare variants contribute to the risk of schizophrenia. Exome sequence data from the UK10K project was used to identify three rare, amino acid changing variants in the ITGB4 gene which segregated with schizophrenia in two families: rs750367954, rs147480547 and rs145976111. Association analysis was carried out in the exome-sequenced Swedish schizophrenia study and in UCL schizophrenia and bipolar cases and controls genotyped for these variants. A gene-wise weighted burden test was performed on a trio sample of schizophrenia cases and their parents...
March 9, 2018: Schizophrenia Research
Brett S Pexa, Eric D Ryan, Joseph B Myers
BACKGROUND: Previous research indicates that the amount of valgus torque placed on the elbow joint during overhead throwing is higher than the medial ulnar collateral ligament (UCL) can tolerate. Wrist and finger flexor muscle activity is hypothesized to make up for this difference, and in vitro studies that simulated activity of upper extremity musculature, specifically the flexor digitorum superficialis and flexor carpi ulnaris, support this hypothesis. PURPOSE: To assess the medial elbow joint space at rest, under valgus stress, and under valgus stress with finger and forearm flexor contraction by use of ultrasonography in vivo...
April 2018: American Journal of Sports Medicine
Christopher Monit, Richard A Goldstein
Summary: Existing ancestral sequence reconstruction techniques are ill-suited to investigating substitutions on a single branch of interest. We present SubRecon, an implementation of a hybrid technique integrating joint and marginal reconstruction for protein sequence data. SubRecon calculates the joint probability of states at adjacent internal nodes in a phylogeny, i.e. how the state has changed along a branch. This does not condition on states at other internal nodes and includes site rate variation...
February 28, 2018: Bioinformatics
Babak Shekarchi, Mohammadreza Mokhdanzadeh Dashti, Mostafa Shahrezaei, Ebrahim Karimi
Introduction: Timely diagnosis and treatment of traumatic injury to ulnar collateral ligament (UCL) of thumb is of special importance for preserving the full function of the hand. Therefore, the present study has been designed with the aim of evaluating the accuracy of ultrasonography in detection of these injuries. Methods: The present diagnostic accuracy study was performed on trauma patients over 15 years old who had clinical evidence of injury to UCL of thumb and were admitted to the emergency department...
2018: Emergency (Tehran, Iran)
K L Lentine, N N Lam, A S Naik, D A Axelrod, Z Zhang, V R Dharnidharka, G P Hess, D L Segev, R Ouseph, H Randall, T Alhamad, R Devraj, R Gadi, B L Kasiske, D C Brennan, M A Schnitzler
Evolving literature suggests that the epidemic of prescription opioid use affects the transplant population. We examined a novel database wherein national U.S. transplant registry records were linked to a large pharmaceutical claims warehouse (2007 to 2015) to characterize prescription opioid use before and after kidney transplant, and associations (adjusted hazard ratio,95% LCL aHR95% UCL ) with death and graft loss. Among 75,430 eligible patients, 43.1% filled opioids in the year before transplant. Use was more common among recipients who were women, white, unemployed, publicly insured, and with longer pre-transplant dialysis...
March 2, 2018: American Journal of Transplantation
Po Li, Yue Yan, Binlong Chen, Pan Zhang, Siling Wang, Jing Zhou, Haiming Fan, Yiguang Wang, Xiaonan Huang
In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems. In this study, we report an NIR imaging diagnosis and therapy nanoplatform which is developed by complexing upconversion nanoparticles (UCNP@OA) NaLuF4 :Er3+ ,Yb3+ with nanographene oxide (NGO). The obtained nanocomposites UCNP@NGO showed excellent stability and low cell toxicity, which not only acted as upconversion luminescence (UCL) probes for tumor imaging, but also served as therapy agents by converting laser energy into thermal energy for photothermal therapy (PTT) with high photothermal conversion efficiency...
March 1, 2018: Biomaterials Science
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