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https://www.readbyqxmd.com/read/28734533/changes-in-pitching-mechanics-after-ulnar-collateral-ligament-reconstruction-in-major-league-baseball-pitchers
#1
Daniel A Portney, Jake M Lazaroff, Lucas T Buchler, Stephen M Gryzlo, Matthew D Saltzman
BACKGROUND: Medial ulnar collateral ligament (UCL) reconstruction is a common procedure performed on Major League Baseball pitchers. Variations in pitching mechanics before and after UCL reconstructive surgery are not well understood. METHODS: Publicly available pitch tracking data (PITCHf/x) were compared for all Major League Baseball pitchers who underwent UCL reconstruction between 2008 and 2013. Specific parameters analyzed were fastball percentage, release location, velocity, and movement of each pitch type...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28730863/non-operative-management-of-ulnar-collateral-ligament-injuries-in-the-throwing-athlete
#2
Mia Smucny, Robert W Westermann, Matthew Winters, Mark S Schickendantz
Medial ulnar collateral ligament (UCL) injuries have become increasingly prevalent in overhead athletes. The orthopaedic literature contains a wealth of information on operative management of these injuries. However, there are few high-quality longitudinal studies on non-operative care of UCL injuries. The purpose of this review is to describe the non-operative approach to managing UCL injuries, including recommended rehabilitation strategies and predictors of successful non-operative treatment.
July 21, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28692505/presurgical-orthopedic-treatment-using-modified-nostril-retainers-in-patients-with-unilateral-cleft-lip-with-or-without-cleft-palate
#3
Serap Titiz, Aynur Aras
This study aimed to present a new technique for presurgical orthopedic treatment of patients with unilateral cleft lip with or without cleft palate (UCL±P) by means of modified nostril retainers manufactured using a special mold with soft acrylic or orthodontic acrylics material. Nasal molding with the modified nostril retainer is considerably effective and comfortable for the patient.
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28686275/power-dependent-upconversion-quantum-yield-of-nayf4-yb-3-er-3-nano-and-micrometer-sized-particles-measurements-and-simulations
#4
Martin Kaiser, Christian Würth, Marco Kraft, Iko Hyppänen, Tero Soukka, Ute Resch-Genger
Photophysical studies of nonlinear lanthanide-doped photon upconverting nanoparticles (UCNPs) increasingly used in biophotonics and photovoltaics require absolute measurements of the excitation power density (P)-dependent upconversion luminescence (UCL) and luminescence quantum yields (ΦUC) for quantifying the material performance, UCL deactivation pathways, and possible enhancement factors. We present here the P-dependence of the UCL spectra, ΦUC, and slope factors of the different emission bands of representative 25 nm-sized oleate-capped β-NaYF4:17% Yb(3+), 3% Er(3+) UCNPs dispersed in toluene and as powder as well as ΦUC of 3 μm-sized upconversion particles (UCμP), all measured with a newly designed integrating sphere setup, enabling controlled variation of P over four orders of magnitude...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28666051/multimodality-approach-to-a-stener-lesion-radiographic-ultrasound-magnetic-resonance-imaging-and-surgical-correlation
#5
Jonathan Tresley, Adam D Singer, Elizabeth A Ouellette, Jason Blaichman, Paul D Clifford
The ulnar collateral ligament (UCL) of the thumb metacarpophalangeal joint is a static stabilizer that may rupture from a hyperabduction injury. Although some UCL tears may heal with immobilization, outcomes are worse for Stener lesions, in which the proximal ligament stump slips out from beneath the adductor pollicis aponeurosis and is entrapped proximal and superficial to the aponeurosis, preventing primary healing. We report the case of a patient with a Stener lesion with radiographic, ultrasound, and magnetic resonance imaging correlation, subsequently confirmed with intraoperative photographs...
May 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28662927/endovascular-treatment-of-abdominal-aortic-aneurysms-with-narrow-aortic-bifurcation-using-excluder-bifurcated-stent-grafts
#6
Pablo Marques De Marino, Isaac Martinez Lopez, Ferran Pla Sanchez, Iñaki Cernuda Artero, Maday Cabrero Fernandez, Oscar Ucles Cabeza, Francisco Javier Serrano Hernando
OBJECTIVE: This study investigated the influence of the aortic bifurcation anatomy on the endovascular treatment of abdominal aortic aneurysms using Excluder (W. L. Gore & Associates, Flagstaff, Ariz) bifurcated stent grafts. METHODS: This was a retrospective single-center study of patients treated with the Excluder stent graft. Analysis included anatomical factors of the aortic bifurcation (aortic bifurcation diameter [ABD], calcification, thrombus), characteristics of the stent graft limbs (sum of stent graft limbs diameters [SLD]), and the SLD/ABD ratio...
June 26, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28657091/depleted-upconversion-luminescence-in-nayf4-yb-3-tm-3-nanoparticles-via-simultaneous-two-wavelength-excitation
#7
Hongxin Zhang, Tianqing Jia, Long Chen, Yuchan Zhang, Shian Zhang, Donghai Feng, Zhenrong Sun, Jianrong Qiu
We report optical depletion of upconversion luminescence (UCL) in NaYF4:Yb(3+),Tm(3+) nanoparticles excited simultaneously by 980 nm and 1550 nm lasers. The UCL intensity is greatly depleted, while the downshifted emission at 1210 nm is obviously enhanced. The disturbances of 1550 nm photons on energy transfer between Yb(3+) and Tm(3+), cross relaxation (CR), the thermal effect and the stimulated emission depletion (STED) process are qualitatively evaluated. Our investigations verify that the unexpected depletion phenomena are governed by the STED process...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28656192/nd-3-sensitized-multicolor-upconversion-luminescence-from-a-sandwiched-core-shell-shell-nanostructure
#8
Shuwei Hao, Guanying Chen, Chunhui Yang, Wei Shao, Wei Wei, Yang Liu, Paras N Prasad
Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted interest for use in bioimaging, biosensing, and therapeutic applications. These motivations are empowered by multicolor upconversion luminescence (UCL) under single near infrared wavelength excitation at ∼980 nm. However, this wavelength overlaps with the absorption peak of water that is dominant in the biological environment, eliciting a serious biological heating problem. This study reports tailored multicolor UCL from a Nd(3+)-sensitized sandwich-structure of core/shell/shell UCNPs of NaYbF4:0...
June 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28654765/a-traffic-light-grading-system-of-hip-dysplasia-to-predict-the-success-of-arthroscopic-hip-surgery
#9
George Grammatopoulos, Owain L I Davies, Ahmed El-Bakoury, Harinderjit S Gill, Tom C B Pollard, Antonio J Andrade
BACKGROUND: The role of hip arthroscopic surgery in dysplasia is controversial. PURPOSE: To determine the 7-year joint preservation rate after hip arthroscopic surgery in hip dysplasia and identify anatomic and intraoperative features that predict the success of hip preservation with arthroscopic surgery, allowing the formulation of an evidence-based classification system. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Between 2008 and 2013, 111 hips with dysplastic features (acetabular index [AI] >10° and/or lateral center-edge angle [LCEA] <25°) that underwent arthroscopic surgery were identified...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28650053/in-situ-crystal-growth-of-gold-nanocrystals-on-upconversion-nanoparticles-for-synergistic-chemo-photothermal-therapy
#10
Ruoyan Wei, Wensong Xi, Haifang Wang, Jinliang Liu, Torsten Mayr, Liyi Shi, Lining Sun
A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility...
June 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28637740/tablet-computers-versus-optical-aids-to-support-education-and-learning-in-children-and-young-people-with-low-vision-protocol-for-a-pilot-randomised-controlled-trial-create-children-reading-with-electronic-assistance-to-educate
#11
Michael D Crossland, Rachel Thomas, Hilary Unwin, Seelam Bharani, Vijaya K Gothwal, Ana Quartilho, Catey Bunce, Annegret Dahlmann-Noor
INTRODUCTION: Low vision and blindness adversely affect education and independence of children and young people. New 'assistive' technologies such as tablet computers can display text in enlarged font, read text out to the user, allow speech input and conversion into typed text, offer document and spreadsheet processing and give access to wide sources of information such as the internet. Research on these devices in low vision has been limited to case series. METHODS AND ANALYSIS: We will carry out a pilot randomised controlled trial (RCT) to assess the feasibility of a full RCT of assistive technologies for children/young people with low vision...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28633344/pheno4j-a-gene-to-phenotype-graph-database
#12
Sajid Mughal, Ismail Moghul, Jing Yu, Tristan Clark, David S Gregory, Nikolas Pontikos
Summary: Efficient storage and querying of large amounts of genetic and phenotypic data is crucial to contemporary clinical genetic research. This introduces computational challenges for classical relational databases, due to the sparsity and sheer volume of the data. Our Java based solution loads annotated genetic variants and well phenotyped patients into a graph database to allow fast efficient storage and querying of large volumes of structured genetic and phenotypic data. This abstracts technical problems away and lets researchers focus on the science rather than the implementation...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28616133/naked-eye-detection-of-multiple-tumor-related-mrnas-from-patients-with-photonic-crystal-micropattern-supported-dual-modal-upconversion-bioprobes
#13
Xiaoxia Hu, Yingqian Wang, Haoyang Liu, Jie Wang, Yaning Tan, Fubing Wang, Quan Yuan, Weihong Tan
Development of a portable device for the detection of multiple mRNAs is a significant need in the early diagnosis of cancer. We have designed a biochip-based mRNA detection device by combining a hydrophilic-hydrophobic micropattern with upconversion luminescence (UCL) probes. The device achieves highly sensitive detection, using the naked eye, of multiple mRNAs among patient samples. The high sensitivity is attributed to enrichment of the target concentration and a fluorescence enhancement effect. In addition, since the photonic crystal (PC) dot biochip is functionalized with dual-wavelength excitation UCL probes, two kinds of mRNAs in the heterogeneous biological samples are detected simultaneously, and the corresponding luminescence signals are captured using an unmodified camera phone...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28613964/early-and-late-onset-preeclampsia-and-the-dna-methylation-of-circadian-clock-and-clock-controlled-genes-in-placental-and-newborn-tissues
#14
C B van den Berg, I Chaves, E M Herzog, S P Willemsen, G T J van der Horst, R P M Steegers-Theunissen
The placenta is important in providing a healthy environment for the fetus and plays a central role in the pathophysiology of preeclampsia (PE). Fetal and placental developments are influenced by epigenetic programming. There is some evidence that PE is controlled to an altered circadian homeostasis. In a nested case-control study embedded in the Rotterdam Periconceptional Cohort, we obtained placental tissue, umbilical cord leukocytes (UCL), and human umbilical venous endothelial cells of 13 early-onset PE, 16 late-onset PE and 83 controls comprising 36 uncomplicated and 47 complicated pregnancies, i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28607764/chronic-medial-instability-of-the-elbow
#15
REVIEW
Felix H Savoie, Michael O'Brien
Damage to the medial collateral ligament of the elbow from an instability episode usually heals with non-operative treatment. In some cases, residual instability may occur, leading to functional impairment.Non-operative management can be successful when bracing, taping and therapy are used to stabilise the elbow.A recent report detailing the efficacy of platelet-rich plasma in effectively treating ulnar collateral ligament (UCL) injuries in throwers has shown promise. However, there remain specific groups that should be considered for repair or reconstruction...
January 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28602305/identification-of-non-intentionally-added-substances-in-food-packaging-nano-films-by-gas-and-liquid-chromatography-coupled-to-orbitrap-mass-spectrometry
#16
M J Martínez-Bueno, M D Hernando, S Uclés, L Rajski, S Cimmino, A R Fernández-Alba
The control of chemical migration from new functionalized food contact materials (FCMs) is a challenge for meeting food safety requirements. The non-intentionally added substances (NIAS) constitute a group of chemicals that are not applied, but may be introduced or formed during the production process of FCMs. This study describes a multi-analytical approach for the evaluation of unknown substances that migrate from FCMs. A case study is presented using a developed polymer consisting of a monolayer film with polylactic acid (PLA), polylimonene (PL) and zinc oxide nanoparticles (ZnO NPs)...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28586045/low-htra1-expression-in-patients-with-long%C3%A2-standing-ulcerative-colitis-and-colorectal-cancer
#17
Emma Altobelli, Giovanni Latella, Manrico Morroni, Caterina Licini, Giovanni Tossetta, Roberta Mazzucchelli, Valerio F Profeta, Gino Coletti, Pietro Leocata, Mario Castellucci, Mario Guerrieri, Reimondo Petrocelli, Berardo De Berardis, Marina De Padova, Gabriella Di Leonardo, Antonella Paladini, Filippo Mignosi, Gina Quaglione, Roberto Fagnano, Daniela Marzioni
The association between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is being increasingly investigated. HtrA1 overexpression inhibits cell growth and proliferation by influencing apoptosis, invasiveness and migration of tumour cells. In the present study, HtrA1 expression was analysed in 228 colon tissue samples from patients with CRC, adenoma with high-grade dysplasia (AHD), adenoma with low-grade dysplasia (ALD), ulcerative colitis of >10 year duration (UCL), ulcerative colitis of <5 year duration (UCS) and colonic diverticulitis (D), and was compared with its expression in normal colon tissues (NCTs) collected 5 cm from the CRC lesion and in healthy colon mucosa (HC), to establish whether HtrA1 can serve as a biomarker for these conditions...
June 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28554915/support-received-after-bereavement-by-suicide-and-other-sudden-deaths-a-cross-sectional-uk-study-of-3432-young-bereaved-adults
#18
Alexandra L Pitman, Khadija Rantell, Paul Moran, Lester Sireling, Louise Marston, Michael King, David Osborn
OBJECTIVE: To test the hypothesis that people bereaved by suicide are less likely to receive formal or informal support than people bereaved by other causes of sudden death. DESIGN: National cross-sectional study. SETTING: Adults working or studying at any UK higher education institution (HEI) in 2010. PARTICIPANTS: A total of 3432 eligible respondents aged 18-40 years bereaved by the sudden death of a close friend or relative, sampled from approximately 659 572 bereaved and non-bereaved staff and students at 37 of 164 UK HEIs invited to participate...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28540851/from-xe-2100-to-xn-9000-from-sis-standard-to-gfhc-recommendations-for-slide-review-potential-impact-on-review-rate-and-turnaround-time
#19
Anne Tamigniau, Nicolas Bailly, Bernard Chatelain, François Mullier
In 2014, we moved from XE-2100 with Standard SIS rules to XN-9000 with GFHC recommendations for slide review. The aim of our study was to evaluate the potential impact of the new Sysmex(®) automation with implementation of GFHC rules on our review rate, turnaround time (TAT), workload and on CD34+ stem cells enumeration. We conducted a retrospective observational study from September 2013 through August 2014, in CHU Dinant Godinne UCL Namur. With the GFHC recommendations and the new Sysmex(®) automation, we significantly reduced our review rate by nearly 30% considering all units (35...
June 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28532867/ultrasound-study-of-elbow-ulnar-collateral-ligament-changes-in-collegiate-baseball-players-a-pilot-study
#20
Johnathan Erb, Heather Sherman, Sydney Williard, Julien Bui, Aimie Kachingwe
OBJECTIVE: To assess changes in elbow ulnar collateral ligament length in college baseball pitchers over the course of a single season. DESIGN: Cohort Feasibility Study. METHODS: Diagnostic ultrasound was used to assess both the dominant and non-dominant medial elbow joint space in four pitchers and five fielders and compared to in-game pitching data. Shoulder, elbow, wrist, hip, knee, and ankle range of motion measurements were also taken...
April 2017: Journal of Bodywork and Movement Therapies
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