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https://www.readbyqxmd.com/read/28540851/from-xe-2100-to-xn-9000-from-sis-standard-to-gfhc-recommendations-for-slide-review-potential-impact-on-review-rate-and-turnaround-time
#1
Anne Tamigniau, Nicolas Bailly, Bernard Chatelain, François Mullier
In 2014, we moved from XE-2100 with Standard SIS rules to XN-9000 with GFHC recommendations for slide review. The aim of our study was to evaluate the potential impact of the new Sysmex(®) automation with implementation of GFHC rules on our review rate, turnaround time (TAT), workload and on CD34+ stem cells enumeration. We conducted a retrospective observational study from September 2013 through August 2014, in CHU Dinant Godinne UCL Namur. With the GFHC recommendations and the new Sysmex(®) automation, we significantly reduced our review rate by nearly 30% considering all units (35...
June 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28532867/ultrasound-study-of-elbow-ulnar-collateral-ligament-changes-in-collegiate-baseball-players-a-pilot-study
#2
Johnathan Erb, Heather Sherman, Sydney Williard, Julien Bui, Aimie Kachingwe
OBJECTIVE: To assess changes in elbow ulnar collateral ligament length in college baseball pitchers over the course of a single season. DESIGN: Cohort Feasibility Study. METHODS: Diagnostic ultrasound was used to assess both the dominant and non-dominant medial elbow joint space in four pitchers and five fielders and compared to in-game pitching data. Shoulder, elbow, wrist, hip, knee, and ankle range of motion measurements were also taken...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28511143/dna-assisted-upconversion-nanoplatform-for-imaging-guided-synergistic-therapy-and-laser-switchable-drug-detoxification
#3
Luoyuan Li, Panlong Hao, Peng Wei, Limin Fu, Xicheng Ai, Jianping Zhang, Jing Zhou
The side effects of chemotherapy bring significant physical and psychological suffering to patients. To solve this urgent medical problem, Yb(3+) and Er(3+) co-doped NaLuF4 upconversion nanoparticles (UCNPs) were constructed for upconversion luminescence (UCL)-labeled diagnosis under 980 nm laser irradiation. The UCNPs were then modified layer by layer with polypyrrole and a special programming DNA segment as photothermal conversion agents and controllable drug carriers, respectively. The nanoplatform was successfully used for imaging-guided synergistic therapy (photothermal therapy and chemotherapy) at a safe power density (300 mW cm(-2)), and DNA-assisted detoxification at lower temperature in cancer cells when the laser off...
May 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28485391/magnetic-resonance-imaging-targeted-transperineal-prostate-biopsy-a-local-anaesthetic-approach
#4
E J Bass, I A Donaldson, A Freeman, C Jameson, S Punwani, C Moore, M Arya, M Emberton, H U Ahmed
BACKGROUND: Despite high rates of disease misclassification and sepsis, the use of transrectal biopsy remains commonplace. Transperineal mapping biopsies mitigate these problems but carry increased cost and patient burden. Local anaesthetic, multiparametric magnetic resonance imaging (MRI)-targeted transperineal biopsy may offer an alternative. Here, we aim to determine the feasibility, tolerability and detection rates of clinically significant prostate cancer using a local anaesthetic, transperineal, MRI-targeted biopsy technique...
May 9, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28480535/integrated-continuous-bioprocessing-economic-operational-and-environmental-feasibility-for-clinical-and-commercial-antibody-manufacture
#5
James Pollock, Jon Coffman, Sa V Ho, Suzanne S Farid
This paper presents a systems approach to evaluating the potential of integrated continuous bioprocessing for monoclonal antibody (mAb) manufacture across a product's lifecycle from pre-clinical to commercial manufacture. The economic, operational and environmental feasibility of alternative continuous manufacturing strategies were evaluated holistically using a prototype UCL decisional tool that integrated process economics, discrete-event simulation, environmental impact analysis, operational risk analysis and multi-attribute decision-making...
May 8, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28463739/a-multifunctional-probe-for-icp-ms-determination-and-multimodal-imaging-of-cancer-cells
#6
Bin Yang, Yuan Zhang, Beibei Chen, Man He, Xiao Yin, Han Wang, Xiaoting Li, Bin Hu
Inductively coupled plasma-mass spectrometry (ICP-MS) based bioassay and multimodal imaging have attracted increasing attention in the current development of cancer research and theranostics. Herein, a sensitive, simple, timesaving, and reliable immunoassay for cancer cells counting and dual-modal imaging was proposed by using ICP-MS detection and down-conversion fluorescence (FL)/upconversion luminescence (UCL) with the aid of a multifunctional probe for the first time. The probe consisted of a recognition unit of goat anti-mouse IgG to label the anti-EpCAM antibody attached cells, a fluorescent dye (Cy3) moiety for FL imaging as well as upconversion nanoparticles (UCNPs) tag for both ICP-MS quantification and UCL imaging of cancer cells...
April 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28456096/identifying-low-density-lipoprotein-cholesterol-associated-variants-in-the-annexin-a2-anxa2-gene
#7
Roaa Hani Fairoozy, Jackie Cooper, Jon White, Claudia Giambartolomei, Lasse Folkersen, S Goya Wannamethee, Barbara J Jefferis, Peter Whincup, Yoav Ben-Shlomo, Meena Kumari, Mika Kivimaki, Andrew Wong, Rebecca Hardy, Diana Kuh, Tom R Gaunt, J P Casas, Stela McLachlan, Jackie F Price, Aroon Hingorani, Anders Franco-Cereceda, Thomas Grewal, Anastasia Z Kalea, Steve E Humphries
BACKGROUND AND AIMS: Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The repeat-one (R1) domain of AnxA2 binds to PCSK9, blocking its ability to promote degradation of low-density lipoprotein cholesterol-receptors (LDL-R) and thereby regulate low-density lipoprotein cholesterol (LDL-C) levels. Here we identify variants in ANXA2 influencing LDL-C levels and we determine the molecular mechanisms of their effects. RESULTS: The ANXA2 single nucleotide polymorphism (SNP) genotype-phenotype association was examined using the Second-Northwick-Park Heart Study (NPHSII) (n∼2700) and the UCL-LSHTM-Edinburgh-Bristol (UCLEB) consortium (n∼14,600)...
April 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28448234/leveraging-clinical-imaging-archives-for-radiomics-reliability-of-automated-methods-for-brain-volume-measurement
#8
Viraj R Adduru, Andrew M Michael, Maria Helguera, Stefi A Baum, Gregory J Moore
Purpose To validate the use of thick-section clinically acquired magnetic resonance (MR) imaging data for estimating total brain volume (TBV), gray matter (GM) volume (GMV), and white matter (WM) volume (WMV) by using three widely used automated toolboxes: SPM ( www.fil.ion.ucl.ac.uk/spm/ ), FreeSurfer ( surfer.nmr.mgh.harvard.edu ), and FSL (FMRIB software library; Oxford Centre for Functional MR Imaging of the Brain, Oxford, England, https://fsl.fmrib.ox.ac.uk/fsl ). Materials and Methods MR images from a clinical archive were used and data were deidentified...
April 27, 2017: Radiology
https://www.readbyqxmd.com/read/28434710/shifting-the-paradigm-in-gas-chromatography-mass-spectrometry-pesticide-analysis-using-high-resolution-accurate-mass-spectrometry
#9
S Uclés, A Uclés, A Lozano, M J Martínez Bueno, A R Fernández-Alba
In the last 10 years, the majority of the pesticide food control laboratories moved from GC-MS to GC-MS/MS as the preferred analytical technique to address GC amenable compounds. The main reason for this change was the negative impact on the single stage GC-MS analysis caused by the interference from coeluting matrix compounds. The new development of gas chromatography coupled to high resolution accurate mass spectrometry (GC-HRAMS) provides opportunities to overcome such matrix interferences as a result of its much higher selectivity; allowing laboratories to carry out full-scan analysis covering the most exigent analytical performance criteria...
April 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28424849/ultrasound-evaluation-of-the-ulnar-collateral-ligament-of-the-elbow-which-method-is-most-reproducible
#10
Mehool Shukla, Robert Keller, Nathan Marshall, Hafeez Ahmed, Courtney Scher, Vasilios Bill Moutzouros, Marnix van Holsbeeck
INTRODUCTION: The ulnar collateral ligament (UCL) is an important medial stabilizer of the elbow, particularly in overhead-throwing athletes. However, there is no universally accepted method for evaluating UCL thickness with ultrasound (US). OBJECTIVE: To assess reproducibility of previously published methods, as well as a modified technique, for evaluating the UCL via US. We hypothesize that a modified technique would show greater reproducibility. MATERIAL AND METHODS: Using US, the thickness of the UCL in 50 volunteers was measured by two musculoskeletal trained radiologists using two different measurement techniques...
April 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28423800/project-peach-at-uclh-student-projects-in-healthcare-computing
#11
Navin Ramachandran, Dean Mohamedally, Paul Taylor
A collaboration between clinicians at UCLH and the Dept of Computer Science at UCL is giving students of computer science the opportunity to undertake real healthcare computing projects as part of their education. This is enabling the creation of a significant research computing platform within the Trust, based on open source components and hosted in the cloud, while providing a large group of students with experience of the specific challenges of health IT.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28419258/eigenthreader-analogous-protein-fold-recognition-by-efficient-contact-map-threading
#12
Daniel Wa Buchan, David T Jones
Motivation: Protein fold recognition when appropriate, evolutionarily-related, structural templates can be identified is often trivial and may even be viewed as a solved problem. However in cases where no homologous structural templates can be detected, fold recognition is a notoriously difficult problem (Moult, Fidelis et al. 2014). Here we present EigenTHREADER, a novel fold recognition method capable of identifying folds where no homologous structures can be identified. EigenTHREADER takes a query amino acid sequence, generates a map of intra-residue contacts, and then searches a library of contact maps of known structures...
April 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28415493/multifunctional-baybf5-gd-er-upconversion-nanoparticles-for-in-vivo-tri-modal-upconversion-optical-x-ray-computed-tomography-and-magnetic-resonance-imaging
#13
Xiaolong Li, Zhigao Yi, Zhenluan Xue, Songjun Zeng, Hongrong Liu
Development of high-quality upconversion nanoparticles (UCNPs) with combination of the merits of multiple molecular imaging techniques, such as, upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and magnetic resonance (MR) imaging, could significantly improve the accuracy of biological diagnosis. In this work, multifunctional BaYbF5: Gd/Er (50:2mol%) UCNPs were synthesized via a solvothermal method using oleic acid (OA) as surface ligands (denoted as OA-UCNPs). The OA-UCNPs were further treated by diluted HCl to form ligand-free UCNPs (LF-UCNPs) for later bioimaging applications...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409916/surfactant-free-aqueous-synthesis-of-novel-ba2gdf7-yb-3-er-3-peg-upconversion-nanoparticles-for-in-vivo-trimodality-imaging
#14
Yang Feng, Hongda Chen, Lina Ma, Baiqi Shao, Shuang Zhao, Zhenxin Wang, Hongpeng You
In this work, we developed the surfactant-free aqueous synthesis of novel polyethylene glycol (PEG) coated Ba2GdF7:Yb(3+), Er(3+) upconversion nanoparticles (named as, Ba2GdF7:Yb(3+), Er(3+)@PEG UCNPs) for in vivo multimodality imaging including upconversion luminescence (UCL), X-ray computed tomography (CT), and T1-weighted magnetic resonance (MR). The as-prepared Ba2GdF7:Yb(3+), Er(3+)@PEG UCNPs not only present bright UCL and reasonably high CT/MR enhancements but also exhibit excellent colloidal stability, inappreciable cytotoxicity, and negligible organ toxicity...
April 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28398820/magnetic-resonance-imaging-predictors-of-failure-in-the-nonoperative-management-of-ulnar-collateral-ligament-injuries-in-professional-baseball-pitchers
#15
Salvatore J Frangiamore, T Sean Lynch, Michael D Vaughn, Lonnie Soloff, Michael Forney, Joseph F Styron, Mark S Schickendantz
BACKGROUND: A medial ulnar collateral ligament (UCL) injury of the elbow is an increasingly common injury in professional baseball pitchers. Predictors of success and failure are not well defined for the nonoperative management of these injuries. PURPOSE: To evaluate the efficacy of objective measures to predict failure of the nonoperative management of UCL injuries. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Thirty-two professional pitchers (82%) met inclusion criteria and underwent an initial trial of nonoperative treatment for UCL tears based on clinical and radiological findings...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28394713/elbow-mri-findings-do-not-correlate-with-future-placement-on-the-disabled-list-in-asymptomatic-professional-baseball-pitchers
#16
Nicholas M Gutierrez, Christopher Granville, Lee Kaplan, Michael Baraga, Jean Jose
BACKGROUND: Injury rates among professional baseball players may reach as high as 5.8 per 1000 encounters, with pitchers being most vulnerable on account of the excessive biomechanical load on the upper extremity during the throwing motion. Anatomically, the shoulder is the most common site of pitching-related injury, accounting for 30.7% of injuries, closely followed by the elbow at 26.3%. Characteristic valgus loading imparts a predictable constellation of stresses on the joint, including medial tension, lateral compression, and posterior medial shearing...
April 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28381344/stability-of-coping-and-the-role-of-self-efficacy-in-the-first-year-following-mild-traumatic-brain-injury
#17
Myrthe E Scheenen, Harm J van der Horn, Myrthe E de Koning, Joukje van der Naalt, Jacoba M Spikman
BACKGROUND AND AIMS: Coping, the psychological adaptation to stressors and serious life events, has been found to have a great influence on the development and persistence of posttraumatic complaints. Coping has received much attention for having been found to be modifiable in treatment following mild traumatic brain injury (mTBI) and for its potential to identify the Patients who are at risk of suffering from long-term complaints. Currently, coping styles are assumed to be stable over time...
May 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28370594/ultrafast-synthesis-of-novel-hexagonal-phase-nabif4-upconversion-nanoparticles-at-room-temperature
#18
Pengpeng Lei, Ran An, Shuang Yao, Qishun Wang, Lile Dong, Xia Xu, Kaimin Du, Jing Feng, Hongjie Zhang
Upconversion (UC) nanoparticles (UCNPs) have evoked considerable attention in many fields owing to their fascinating features. However, rigorous synthesis conditions and expensive raw materials often limit their further applications. Here, a novel hexagonal phase NaBiF4 UC matrix through a very facile method (one min only at room temperature) is synthesized. The nanoparticles show good monodispersity with uniform size. Under the 980 nm irradiation, Yb(3+) /Ln(3+) (Ln = Er, Ho, Tm) codoped NaBiF4 nanoparticles show excellent UC luminescence (UCL)...
April 3, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28368021/flexible-transparent-displays-based-on-core-shell-upconversion-nanophosphor-incorporated-polymer-waveguides
#19
Bong Je Park, A-Ra Hong, Suntak Park, Ki-Uk Kyung, Kwangyeol Lee, Ho Seong Jang
Core/shell (C/S)-structured upconversion nanophosphor (UCNP)-incorporated polymer waveguide-based flexible transparent displays are demonstrated. Bright green- and blue-emitting Li(Gd,Y)F4:Yb,Er and Li(Gd,Y)F4:Yb,Tm UCNPs are synthesized via solution chemical route. Their upconversion luminescence (UCL) intensities are enhanced by the formation of C/S structure with LiYF4 shell. The Li(Gd,Y)F4:Yb,Er/LiYF4 and Li(Gd,Y)F4:Yb,Tm/LiYF4 C/S UCNPs exhibit 3.3 and 2.0 times higher UCL intensities than core counterparts, respectively...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28364630/charge-convertibility-and-near-infrared-photon-co-enhanced-cisplatin-chemotherapy-based-on-upconversion-nanoplatform
#20
Jiating Xu, Ye Kuang, Ruichan Lv, Piaoping Yang, Chunxia Li, Huiting Bi, Bin Liu, Dan Yang, Yunlu Dai, Shili Gai, Fei He, Bengang Xing, Jun Lin
Optimal nano-sized drug carrier requires long blood circulation, selective extravasation, and efficient cell uptake. Here we develop a charge-convertible nanoplatform based on Pt(IV) prodrug loaded NaYF4:Yb,Tm upconversion nanoparticles (UCNs), followed by coating a layer of PEG-PAH-DMMA polymer (UCNs-Pt(IV)@PEG-PAH-DMMA). The polymer endows the platform with high biocompatibility, initial nano-size for prolonged blood circulation and selective extravasation. Especially, the anionic polymer can response to the mild acidic stimulus (pH ∼6...
June 2017: Biomaterials
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