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https://www.readbyqxmd.com/read/27912956/further-comments-on-some-core-arguments-from-a-discussion-about-is-traditional-chinese-medicine-really-relevant
#1
Xiao Ye
A discussion on "Is traditional Chinese medicine (TCM) really relevant?" was held in the University College London (UCL) on the afternoon of 31st March, 2015. The author summarized some core viewpoints of the participants and then tried to focus on the opponent's opinions to clear up the arguments by illustrating respects of history, knowledge learning process, evidence based medicine (EBM) and strengths of TCM. This article will propose that the human health is extremely delicate and complicated and that no system of medicine can resolve all the problems of the human body...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27886770/multiresidue-method-for-trace-pesticide-analysis-in-honeybee-wax-comb-by-gc-qqq-ms
#2
M D Gil García, S Uclés Duque, A B Lozano Fernández, A Sosa, A R Fernández-Alba
The aim of this analytical study is to develop an improved multi-residue methodology of high sensitivity and expanded scope for pesticide residue analysis in honeybee wax combs. The method was validated for 160 pesticide residues (including acaricides, insecticides, fungicides and herbicides) gas chromatography amenable and covering a wide variety of polarity and chemical structure. This method of analysis applied gas chromatography coupled to a triple quadrupole mass spectrometer for the quantitative analysis of pesticide residues...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27872588/conversation-therapy-with-people-with-aphasia-and-conversation-partners-using-video-feedback-a-group-and-case-series-investigation-of-changes-in-interaction
#3
Wendy Best, Jane Maxim, Claudia Heilemann, Firle Beckley, Fiona Johnson, Susan I Edwards, David Howard, Suzanne Beeke
Conversation therapies employing video for feedback and to facilitate outcome measurement are increasingly used with people with post-stroke aphasia and their conversation partners; however the evidence base for change in everyday interaction remains limited. We investigated the effect of Better Conversations with Aphasia (BCA), an intervention that is freely available online at https://extend.ucl.ac.uk/. Eight people with chronic agrammatic aphasia, and their regular conversation partners participated in the tailored 8 week program involving significant video feedback...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27863432/e-cadherin-downregulation-sensitizes-pten-mutant-tumors-to-pi3k%C3%AE-silencing
#4
África Millán-Uclés, Susana Zuluaga, Miriam Marqués, Jesus Vallejo-Díaz, Lorena Sanz, Ariel E Cariaga-Martínez, Francisco X Real, Ana C Carrera
Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated in PTEN-mutant tumors, has kinase-dependent and -independent activities, we compared the effects of depleting vs. drug-inhibiting PI3Kβ kinase activity in a collection of diverse tumor types and in a set of bladder carcinoma cell lines grown as xenografts in mice. PI3Kβ depletion (by intratumor injection of PIK3CB siRNA) induced apoptosis and triggered regression of PTEN-mutant tumors more efficiently than PI3Kβ inhibition...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27851974/eforge-a-tool-for-identifying-cell-type-specific-signal-in-epigenomic-data
#5
Charles E Breeze, Dirk S Paul, Jenny van Dongen, Lee M Butcher, John C Ambrose, James E Barrett, Robert Lowe, Vardhman K Rakyan, Valentina Iotchkova, Mattia Frontini, Kate Downes, Willem H Ouwehand, Jonathan Laperle, Pierre-Étienne Jacques, Guillaume Bourque, Anke K Bergmann, Reiner Siebert, Edo Vellenga, Sadia Saeed, Filomena Matarese, Joost H A Martens, Hendrik G Stunnenberg, Andrew E Teschendorff, Javier Herrero, Ewan Birney, Ian Dunham, Stephan Beck
Epigenome-wide association studies (EWAS) provide an alternative approach for studying human disease through consideration of non-genetic variants such as altered DNA methylation. To advance the complex interpretation of EWAS, we developed eFORGE (http://eforge.cs.ucl.ac.uk/), a new standalone and web-based tool for the analysis and interpretation of EWAS data. eFORGE determines the cell type-specific regulatory component of a set of EWAS-identified differentially methylated positions. This is achieved by detecting enrichment of overlap with DNase I hypersensitive sites across 454 samples (tissues, primary cell types, and cell lines) from the ENCODE, Roadmap Epigenomics, and BLUEPRINT projects...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27825669/outcome-of-patients-with-advanced-ovarian-cancer-who-do-not-undergo-debulking-surgery-a-single-institution-retrospective-review
#6
Claudia Marchetti, Rebecca Kristeleit, Mary McCormack, Tim Mould, Adeola Olaitan, Martin Widschwendter, Nicola MacDonald, Jonathan A Ledermann
OBJECTIVE: To assess the outcome of patients with advanced ovarian cancer (OC) who were treated without surgery, having received upfront chemotherapy and no interval debulking surgery (IDS). METHODS: Retrospective analysis of medical and chemotherapy records of consecutive patients with OC between 2005 and 2013 at UCL Hospitals London, UK who received neoadjuvant chemotherapy (NACT) was then found to be unsuitable for IDS following review by the multidisciplinary team...
November 5, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27824873/evaluating-varied-label-designs-for-use-with-medical-devices-optimized-labels-outperform-existing-labels-in-the-correct-selection-of-devices-and-time-to-select
#7
Laura Bix, Do Chan Seo, Moslem Ladoni, Eric Brunk, Mark W Becker
PURPOSE: Effective standardization of medical device labels requires objective study of varied designs. Insufficient empirical evidence exists regarding how practitioners utilize and view labeling. OBJECTIVE: Measure the effect of graphic elements (boxing information, grouping information, symbol use and color-coding) to optimize a label for comparison with those typical of commercial medical devices. DESIGN: Participants viewed 54 trials on a computer screen...
2016: PloS One
https://www.readbyqxmd.com/read/27821657/the-ucl-low-density-lipoprotein-receptor-gene-variant-database-pathogenicity-update
#8
Sarah Leigh, Marta Futema, Ros Whittall, Alison Taylor-Beadling, Maggie Williams, Johan T den Dunnen, Steve E Humphries
BACKGROUND: Familial hypercholesterolaemia (OMIM 143890) is most frequently caused by variations in the low-density lipoprotein receptor (LDLR) gene. Predicting whether novel variants are pathogenic may not be straightforward, especially for missense and synonymous variants. In 2013, the Association of Clinical Genetic Scientists published guidelines for the classification of variants, with categories 1 and 2 representing clearly not or unlikely pathogenic, respectively, 3 representing variants of unknown significance (VUS), and 4 and 5 representing likely to be or clearly pathogenic, respectively...
November 7, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27795946/treatment-of-the-ulnar-nerve-for-overhead-throwing-athletes-undergoing-ulnar-collateral-ligament-reconstruction
#9
REVIEW
Matthew S Conti, Christopher L Camp, Neal S Elattrache, David W Altchek, Joshua S Dines
Ulnar nerve (UN) injuries are a common complaint amongst overhead athletes. The UN is strained during periods of extreme valgus stress at the elbow, especially in the late-cocking and early acceleration phases of throwing. Although early ulnar collateral ligament (UCL) reconstruction techniques frequently included routine submuscular UN transposition, this is becoming less common with more modern techniques. We review the recent literature on the sites of UN compression, techniques to evaluate the UN nerve, and treatment of UN pathology in the overhead athlete...
October 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/27766274/the-relationship-between-humeral-retrotorsion-and-shoulder-range-of-motion-in-baseball-players-with-an-ulnar-collateral-ligament-tear
#10
Bobby Jean S Lee, J Craig Garrison, John E Conway, Kalyssa Pollard, Subhash Aryal
BACKGROUND: Humeral retrotorsion has been investigated in relation to shoulder range of motion (ROM) in healthy baseball players. Currently, there is limited information on the osseous anatomy and development of ulnar collateral ligament (UCL) tears. PURPOSE: To determine the relationship between humeral retrotorsion and shoulder ROM in baseball players with a UCL tear. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: Fifty-four baseball players (mean age, 18...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27745805/internet-resources-for-tommy-john-injuries-what-are-patients-reading
#11
Christine C Johnson, Grant H Garcia, Joseph N Liu, Jeffrey G Stepan, Ronak M Patel, Joshua S Dines
BACKGROUND: The quality of medical information on the Internet has come under scrutiny. This study investigates the quality, accuracy, and readability of online information regarding ulnar collateral ligament (UCL) injuries. METHODS: Three search terms ("elbow ulnar collateral ligament injury," "tommy john injury," and "pitcher's elbow") were entered into 3 Internet search engines. Three independent reviewers evaluated the content and accuracy of the information with a set of predetermined scoring criteria...
October 10, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27736038/multidisciplinary-treatment-in-children-with-problematic-severe-asthma-a-prospective-evaluation
#12
Marieke Verkleij, Anita Beelen, Bart E van Ewijk, Rinie Geenen
OBJECTIVE: For children with problematic severe asthma, achieving adequate control of asthma is difficult. The aim of this prospective observational study was to evaluate the effects of intensive multidisciplinary inpatient treatment on multiple outcome variables in children with problematic severe asthma. METHODS: Participants were 89 children with problematic severe asthma (mean age 13.6 ± 2.5 years) treated in tertiary care clinics at high altitude (Switzerland) or sea level (Netherlands) and their parents (85 mothers, 55 fathers)...
October 13, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27698632/long-term-outcomes-of-primary-repair-of-chronic-thumb-ulnar-collateral-ligament-injuries
#13
Thomas Christensen, Shumaila Sarfani, Alexander Y Shin, Sanjeev Kakar
Background: The purpose of this study is to evaluate long-term outcomes of ligamentous repair rather than reconstruction for chronic thumb ulnar collateral ligament (UCL) injuries. Methods: Patients at least 15-years status-post repair of a chronic (greater than 6 weeks) UCL tear were contacted for clinical evaluation, radiographs, and postoperative outcome questionnaires, including the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, visual analog scale (VAS) pain scale, and study-specific questions...
September 2016: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/27697580/nanoknife-electroporation-ablation-trial-a-prospective-development-study-investigating-focal-irreversible-electroporation-for-localized-prostate-cancer
#14
Massimo Valerio, Louise Dickinson, Afia Ali, Navin Ramachadran, Ian Donaldson, Neil Mccartan, Alex Freeman, Hashim U Ahmed, Mark Emberton
PURPOSE: Irreversible electroporation has attractive attributes for focal ablation, namely nonthermal effect, precise demarcation of treatment and tissue selectivity. We report a prospective development study investigating focal irreversible electroporation. MATERIALS AND METHODS: A total of 20 men with certain characteristics were recruited for study, including a visible index lesion on anterior magnetic resonance imaging that was concordant with transperineal targeted and template prostate mapping biopsy, absent clinically significant disease noted elsewhere (University College London definition 2) and prostate specific antigen 15 ng/ml or less...
September 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27697219/a-new-biological-and-clinical-resource-for-research-into-pregnancy-complications-the-baby-bio-bank
#15
Lydia J Leon, Nita Solanky, Susanne E Stalman, Charalambos Demetriou, Sayeda Abu-Amero, Philip Stanier, Lesley Regan, Gudrun E Moore
About 20% of pregnancies are affected by some form of complication. Research has shown that anomalies in implantation, development, and growth of the fetus; ineffective nutrient exchange between mother and fetus due to placental dysfunction; and maternal problems such as hypertension or infection during pregnancy can all lead to adverse pregnancy outcomes. However, the molecular aetiology of such events remains poorly understood. Fetal growth restriction (FGR), recurrent miscarriage (RM), preterm birth (PTB), and pre-eclampsia (PE) are the most common pregnancy complications encountered in the UK and these outcomes can result in an array of morbidities in both mother and baby, and in the most severe cases in mortality...
October 2016: Placenta
https://www.readbyqxmd.com/read/27696854/optimization-of-bi3-in-upconversion-nanoparticles-induced-simultaneous-enhancement-of-near-infrared-optical-and-x-ray-computed-tomography-imaging-capability
#16
Pengpeng Lei, Peng Zhang, Shuang Yao, Shuyan Song, Lile Dong, Xia Xu, Xiuling Liu, Kaimin Du, Jing Feng, Hongjie Zhang
Bioimaging probes have been extensive studied for many years, while it is still a challenge to further improve the image quality for precise diagnosis in clinical medicine. Here, monodisperse NaGdF4:Yb3+,Tm3+,x% Bi3+ (abbreviated as GYT-x% Bi3+, x = 0, 5, 10, 15, 20, 25, 30) upconversion nanoparticles (UCNPs) have been prepared through solvothermal method. The near-infrared upconversion emission intensity of GYT-25% Bi3+ has been enhanced remarkably than that of NaGdF4:Yb3+,Tm3+ (GYT) with a factor of ~60. Especially, the near-infrared upconversion emission band centered at 802 nm is 150 times stronger than the blue emission band of GYT-25% Bi3+ UCNPs...
October 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27689969/an-international-randomised-controlled-trial-to-compare-targeted-intraoperative-radiotherapy-targit-with-conventional-postoperative-radiotherapy-after-breast-conserving-surgery-for-women-with-early-stage-breast-cancer-the-targit-a-trial
#17
Jayant S Vaidya, Frederik Wenz, Max Bulsara, Jeffrey S Tobias, David J Joseph, Christobel Saunders, Chris Brew-Graves, Ingrid Potyka, Stephen Morris, Hrisheekesh J Vaidya, Norman R Williams, Michael Baum
BACKGROUND: Based on our laboratory work and clinical trials we hypothesised that radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In collaboration with the industry we developed a new radiotherapy device and a new surgical operation for delivering single-dose radiation to the tumour bed - the tissues at highest risk of local recurrence. We named it TARGeted Intraoperative radioTherapy (TARGIT). From 1998 we confirmed its feasibility and safety in pilot studies...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27677533/effects-of-different-dietary-tryptophan%C3%A2-%C3%A2-lysine-ratios-and-sanitary-conditions-on-growth-performance-plasma-urea-nitrogen-serum-haptoglobin-and-ileal-histomorphology-of-weaned-pigs
#18
Balachandar Jayaraman, John K Htoo, Charles M Nyachoti
A total of 180 mixed-sex pigs (Duroc × (Yorkshire × Landrace); average initial body weight of 7.36 ± 0.2 kg) weaned at 21 ± 1 days were fed corn-soybean meal-wheat-based diets to determine the optimal standardized ileal digestible (SID) tryptophan to lysine ratio (Trp : Lys) in a 2 × 5 factorial arrangement (two sanitary conditions: clean (CL) and unclean (UCL), and five dietary treatments (SID Trp : Lys (16, 18, 20, 22 and 24%)). In each sanitary condition, blood was collected on days 0 and 14 to determine plasma urea nitrogen and on day 14, ileal tissue (one pig per pen) was collected for the measurement of gut morphology...
September 28, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27673597/targeted-multimodal-nano-reporters-for-pre-procedural-mri-and-intra-operative-image-guidance
#19
Joonseok Lee, Andrew C Gordon, Hacksung Kim, Wooram Park, Soojeong Cho, Byeongdu Lee, Andrew C Larson, Elena A Rozhkova, Dong-Hyun Kim
Multimodal-imaging probes offer a novel approach, which can provide detail diagnostic information for the planning of image-guided therapies in clinical practice. Here we report targeted multimodal Nd(3+)-doped upconversion nanoparticle (UCNP) imaging reporters, integrating both magnetic resonance imaging (MRI) and real-time upconversion luminescence imaging (UCL) capabilities within a single platform. Nd(3+)-doped UCNPs were synthesized as a core-shell structure showing a bright visible emission upon excitation at the near infrared (minimizing biological overheating and increasing tissue penetration depth) as well as providing strong MRI T2 contrast (high r2/r1 ratio)...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27666612/clinical-evaluation-vs-magnetic-resonance-imaging-of-the-skier-s-thumb-a-prospective-cohort-of-30-patients
#20
Mandhkani Mahajan, Christine Tolman, B Würth, Steven J Rhemrev
INTRODUCTION: A skiers thumb, or a partial or complete rupture of the ulnar collateral ligament (UCL) is a clinical diagnosis. Swelling, pain, natural left-right difference and inexperience of a young physician can cause difficulty to correctly diagnose this injury. However, our theory is that any physician, given the correct instructions, should be able to diagnose this injury solely on clinical findings, without the necessity of additional imaging. MATERIAL AND METHODS: In a large Dutch teaching hospital, physicians (residents with working experience of 6months-3years) working at the ER received instructions for physical examination...
October 2016: European Journal of Radiology
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