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Neuro-oncology

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https://www.readbyqxmd.com/read/28210785/on-glioblastoma-and-the-search-for-a-cure-where-do-we-stand
#1
REVIEW
John Bianco, Chiara Bastiancich, Aleksander Jankovski, Anne des Rieux, Véronique Préat, Fabienne Danhier
Although brain tumours have been documented and recorded since the nineteenth century, 2016 marked 90 years since Percival Bailey and Harvey Cushing coined the term "glioblastoma multiforme". Since that time, although extensive developments in diagnosis and treatment have been made, relatively little improvement on prognosis has been achieved. The resilience of GBM thus makes treating this tumour one of the biggest challenges currently faced by neuro-oncology. Aggressive and robust development, coupled with difficulties of complete resection, drug delivery and therapeutic resistance to treatment are some of the main issues that this nemesis presents today...
February 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28208698/advances-in-molecular-imaging-of-locally-delivered-targeted-therapeutics-for-central-nervous-system-tumors
#2
REVIEW
Umberto Tosi, Christopher S Marnell, Raymond Chang, William C Cho, Richard Ting, Uday B Maachani, Mark M Souweidane
Thanks to the recent advances in the development of chemotherapeutics, the morbidity and mortality of many cancers has decreased significantly. However, compared to oncology in general, the field of neuro-oncology has lagged behind. While new molecularly targeted chemotherapeutics have emerged, the impermeability of the blood-brain barrier (BBB) renders systemic delivery of these clinical agents suboptimal. To circumvent the BBB, novel routes of administration are being applied in the clinic, ranging from intra-arterial infusion and direct infusion into the target tissue (convection enhanced delivery (CED)) to the use of focused ultrasound to temporarily disrupt the BBB...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28204993/needs-of-neuro-oncological-patients-and-their-caregivers-during-the-hospitalization-and-after-discharge-results-from-a-longitudinal-study
#3
C Scaratti, M Leonardi, A Saladino, E Anghileri, M Broggi, E Lamperti, L Fariselli, R Ayadi, G Tringali, S Schiavolin
PURPOSE: The aims of this study are to identify neuro-oncological patients' and their caregivers' needs during hospitalization (T0) and at 4 months after discharge (T1); to analyze the longitudinal changes in patients' and caregivers' needs and burden; to identify correlations between patients' needs and caregivers' burden and needs. METHODS: A pilot observational longitudinal study was conducted on 94 neuro-oncological patients and their caregivers using NEQ to evaluate patients' needs, CNA, and FSQ for caregivers' needs and burden at T0 and T1...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28197403/network-plasticity-and-intraoperative-mapping-for-personalized-multimodal-management-of-diffuse-low-grade-gliomas
#4
REVIEW
Cristina Diana Ghinda, Hugues Duffau
Gliomas are the most frequent primary brain tumors and include a variety of different histological tumor types and malignancy grades. Recent achievements in terms of molecular and imaging fields have created an unprecedented opportunity to perform a comprehensive interdisciplinary assessment of the glioma pathophysiology, with direct implications in terms of the medical and surgical treatment strategies available for patients. The current paradigm shift considers glioma management in a comprehensive perspective that takes into account the intricate connectivity of the cerebral networks...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28190444/management-of-neuro-oncologic-emergencies
#5
J T Jo, D Schiff
Patients with brain tumors and systemic malignancies are subject to diverse neurologic complications that require urgent evaluation and treatment. These neurologic conditions are commonly due to the tumor's direct effects on the nervous system, such as cerebral edema, increased intracranial pressure, seizures, spinal cord compression, and leptomeningeal metastases. In addition, neurologic complications can develop as a result of thrombocytopenia, coagulopathy, hyperviscosity syndromes, infection, immune-related disorders, and adverse effects of treatment...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28165649/intracellular-ph-measured-by-31-p-mr-spectroscopy-might-predict-site-of-progression-in-recurrent-glioblastoma-under-antiangiogenic-therapy
#6
Katharina J Wenger, Elke Hattingen, Kea Franz, Joachim P Steinbach, Oliver Bähr, Ulrich Pilatus
PURPOSE: In solid tumors, changes in the expression/activity of plasma membrane ion transporters facilitate proton efflux and enable tumor cells to maintain a higher intracellular pH (pHi ), while the microenvironment (pHe ) is commonly more acidic. This supports various tumor-promoting mechanisms. We propose that these changes in pH take place before a magnetic resonance imaging (MRI)-detectable brain tumor recurrence occurs. MATERIALS AND METHODS: We enrolled 66 patients with recurrent glioblastoma, treated with bevacizumab...
February 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28162255/direct-electrical-bipolar-electrostimulation-for-functional-cortical-and-subcortical-cerebral-mapping-in-awake-craniotomy-practical-considerations
#7
J Pallud, O Rigaux-Viode, R Corns, J Muto, C Lopez Lopez, C Mellerio, X Sauvageon, E Dezamis
INTRODUCTION: The aim of brain glioma surgery is to maximize the quality of resection, while minimizing the risk of sequelae. Due to the frequent location of gliomas near or within eloquent areas, owing to their infiltrative feature, and because of major interindividual variability, the anatomofunctional organization and connectivity must be studied individually. Therefore, to optimize the benefit-to-risk ratio of surgery, intraoperative functional mapping is extensively used. MATERIAL AND METHODS: This article aims at describing the rationale, indications and practical aspects of intraoperative direct electrical bipolar electrostimulation for cortical and subcortical mapping under awake conditions using the asleep-awake asleep anaesthetic protocol in the setting of cerebral gliomas...
February 2, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28161011/surgical-resection-of-incidental-diffuse-gliomas-involving-eloquent-brain-areas-rationale-functional-epileptological-and-oncological-outcomes
#8
G L O Lima, E Dezamis, R Corns, O Rigaux-Viode, S Moritz-Gasser, A Roux, H Duffau, J Pallud
OBJECTIVE: Incidentally discovered diffuse low-grade gliomas progress in a fashion similar to their symptomatic counterparts. Their early detection allows more effective pre-emptive and individualized oncological treatment. We assessed the safety and efficacy of maximal safe resection according to functional boundaries for incidental diffuse low-grade gliomas in eloquent areas. MATERIAL AND METHODS: Two-centre retrospective series of adult patients with incidental diffuse low-grade gliomas located within/close to eloquent areas in the dominant hemisphere, treated with maximal surgical resection according to functional boundaries under intraoperative functional cortico-subcortical monitoring under awake conditions, and with a minimal follow-up of 24months...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28160826/-the-nurse-and-management-of-glioblastoma
#9
Marion Pichaut
Lead nurses in neuro-oncology support patients with glioblastoma and their family from the time of diagnosis. They work closely with all health professionals practising in hospitals and in the home. They coordinate patients' care pathways, from the diagnosis consultation to their death.
February 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28156540/family-camp-a-multi-disciplinary-intervention-for-brain-tumor-patients-and-families
#10
Mary Lovely, Abigail Levinson Marks, Amanda K LaMarre, Susan M Chang, Jennifer Clarke, Judy Patt, Emelia Barani
: 240 Background: The diagnosis of a brain tumor is a catastrophic life changing event that impacts the entire family. Patients and caregivers experience dramatic role changes, concern for their children, financial stress, and isolation. For many, the situation is overwhelming. A novel intervention to address these needs is "Family Camp". Our vision for camp was to provide respite to the entire family, decrease caregiver stress, improve family connections and promote a sense of understanding and connection with the community at large...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156536/caregiver-time-burden-in-newly-diagnosed-glioblastoma-a-prospective-analysis
#11
Christine Pittman, Nimish Mohile
: 242 Background: Caregiver (CG) burden is particularly high in glioblastoma (GBM) because neurologic deficits lead to cognitive dysfunction and physical dependence. The amount of time that CGs devote to GBM pts is not well described. The extent to which time burden impacts CG quality of life and perceived burden is unknown. METHODS: We performed an IRB-approved prospective analysis of 38 CGs of pts with newly diagnosed GBM enrolled over 8 mo. at a single academic institution...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152843/building-a-new-process-nursing-verification-of-pediatric-oral-chemotherapy
#12
Erin Santacroce, Mary Ann Zimmerman, Melissa Freeman, Teresa Lau Greenberg, Phuong Nguyen, Susan N Chi, Pratiti Bandopadhayay, Sharon Lane, Audrea Szabatura, Kathleen Houlahan, Amy Billett
: 199 Background: While team-based safety checks ensure safe prescribing of parenteral chemotherapy, oral chemotherapy is usually prescribed by a single clinician. With the growing use of oral chemotherapy, processes are needed to protect these vulnerable patients from prescription errors. METHODS: A team of nurses, clinicians, pharmacists and administrators developed a new process and checklist for nursing verification of oral chemotherapy prescriptions at Dana-Farber's pediatric neuro-oncology program...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152822/the-value-of-secondary-pathology-review
#13
Tinisha L Mayo, Tracy E Spinks, Richard Cheney, Peiguo Chu, Harry S Cooper, Suzanne Dintzis, Hormoz Ehya, Christopher D Fletcher, Amy Gerwirtz, Anthony Martin Magliocco, Sue Ellen Martin, Andrew E Rosenberg, Andy Sherrod, Lee K Tan, Brent L Wood, Ronald Stewart Walters
: 6 Background: Improving the value of cancer care is a major focus for the Alliance of Dedicated Cancer Centers (ADCC). Looking to align with the Institute of Medicine's (IOM) initiative to "Develop and deploy approaches to identify, learn from, and reduce diagnostic errors and near misses in clinical practice," the ADCC implemented a study to examine the clinical impact of expert secondary pathology review. The goal of this project was to: 1) demonstrate the value of secondary review of outside pathological specimens by ADCC subspecialty pathologists in identifying significant errors that can potentially impact treatment; and 2) create an opportunity to improve patient cancer care...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152815/development-of-an-integrated-practice-unit-utilizing-a-lean-approach-to-impact-value-of-care-for-brain-tumor-patients
#14
Christine Ahn, Preston White, Linda M Liau, Timothy Francis Cloughesy, Phioanh Leia Nghiemphu
: 99 Background: Lack of care coordination across subspecialty departments involved in the treatment of brain tumor patients at our institution has negatively impacted patient outcomes, patient experience, and costs. Meanwhile, value-based health care has become increasingly relevant as a means to respond to changing payment structures and improve quality. With the aim to increase value, we restructured medical practice across the continuum of care for brain tumor patients by developing a virtual (non co-located) Integrated Practice Unit (IPU)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150189/development-of-a-questionnaire-measuring-instrumental-activities-of-daily-living-iadl-in-patients-with-brain-tumors-a-pilot-study
#15
Q Oort, L Dirven, W Meijer, S A M Sikkes, B M J Uitdehaag, J C Reijneveld, M J B Taphoorn
Both dementia and brain tumor patients exhibit cognitive decline during the course of their disease. They might therefore experience similar problems with cognitively complex daily activities (i.e., instrumental activities of daily living (IADL)). The study's objective is to evaluate if the Amsterdam IADL Questionnaire(©) (A-IADL-Q), a 70-item IADL questionnaire developed for and validated in early dementia patients, is also applicable to glioma patients. The evaluation consisted of three steps. Predetermined decision rules defined which activities were retained, altered, added or excluded...
February 1, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28149967/3d-deep-learning-for-multi-modal-imaging-guided-survival-time-prediction-of-brain-tumor-patients
#16
Dong Nie, Han Zhang, Ehsan Adeli, Luyan Liu, Dinggang Shen
High-grade glioma is the most aggressive and severe brain tumor that leads to death of almost 50% patients in 1-2 years. Thus, accurate prognosis for glioma patients would provide essential guidelines for their treatment planning. Conventional survival prediction generally utilizes clinical information and limited handcrafted features from magnetic resonance images (MRI), which is often time consuming, laborious and subjective. In this paper, we propose using deep learning frameworks to automatically extract features from multi-modal preoperative brain images (i...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28138871/clinical-relevance-of-steroid-use-in-neuro-oncology
#17
REVIEW
K Ina Ly, Patrick Y Wen
BACKGROUND: Corticosteroids are commonly used in the management of primary central nervous system (CNS) tumors and CNS metastases to treat cancer- and treatment-related cerebral edema and improve neurologic function. However, they are also associated with significant morbidity and mortality, given their wide range of adverse effects. PURPOSE OF REVIEW: To review the mechanism of action, pharmacology, and toxicity profile of corticosteroids and to critically appraise the evidence that supports their use in neuro-oncologic practice based on the latest scientific and clinical data...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28128894/examining-the-sustainability-of-screening-for-distress-the-sixth-vital-sign-in-two-outpatient-oncology-clinics-a-mixed-methods-study
#18
Shannon Groff, Jayna Holroyd-Leduc, Deborah White, Barry D Bultz
BACKGROUND: Research indicates that cancer patients experience significant multifactorial distress during their journey. To address this, cancer centers are implementing Screening for Distress programs; however, little is known about the sustainability of these programs. This study sought to examine the sustainability of a Screening for Distress program in two cancer clinics six months post-implementation. METHODS: A mixed-method cross-sectional design was utilized...
January 27, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28117260/linear-accelerator-radiosurgery-for-arteriovenous-malformations-updated-literature-review
#19
S Yahya, G Heyes, P Nightingale, S Lamin, S Chavda, I Geh, D Spooner, G Cruickshank, P Sanghera
Arteriovenous malformations (AVMs) are the leading causing of intra-cerebral haemorrhage. Stereotactic radiosurgery (SRS) is an established treatment for arteriovenous malformations (AVM) and commonly delivered using Gamma Knife within dedicated radiosurgery units. Linear accelerator (LINAC) SRS is increasingly available however debate remains over whether it offers an equivalent outcome. The aim of this project is to evaluate the outcomes using LINAC SRS for AVMs used within a UK neurosciences unit and review the literature to aid decision making across various SRS platforms...
January 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28106065/neuro-oncology-in-2016-advances-in-brain-tumour-classification-and-therapy
#20
Matthias Preusser, Christine Marosi
No abstract text is available yet for this article.
February 2017: Nature Reviews. Neurology
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