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https://www.readbyqxmd.com/read/28335291/multispectral-emissions-of-lanthanide-doped-gadolinium-oxide-nanophosphors-for-cathodoluminescence-and-near-infrared-upconversion-downconversion-imaging
#1
Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Takumi Sannomiya, Kaori Kobayashi, Hiroshi Yukawa, Yoshinobu Baba, Mamoru Hashimoto, Jun Miyake
Comprehensive imaging of a biological individual can be achieved by utilizing the variation in spatial resolution, the scale of cathodoluminescence (CL), and near-infrared (NIR), as favored by imaging probe Gd₂O₃ co-doped lanthanide nanophosphors (NPPs). A series of Gd₂O₃:Ln(3+)/Yb(3+) (Ln(3+): Tm(3+), Ho(3+), Er(3+)) NPPs with multispectral emission are prepared by the sol-gel method. The NPPs show a wide range of emissions spanning from the visible to the NIR region under 980 nm excitation. The dependence of the upconverting (UC)/downconverting (DC) emission intensity on the dopant ratio is investigated...
September 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28327564/quantification-of-whole-body-and-segmental-skeletal-muscle-mass-using-phase-sensitive-8-electrode-medical-bioelectrical-impedance-devices
#2
A Bosy-Westphal, B Jensen, W Braun, M Pourhassan, D Gallagher, M J Müller
BACKGROUND/OBJECTIVES: Bioelectrical impedance analysis (BIA) provides noninvasive measures of skeletal muscle mass (SMM) and visceral adipose tissue (VAT). This study (i) analyzes the impact of conventional wrist-ankle vs segmental technology and standing vs supine position on BIA equations and (ii) compares BIA validation against magnetic resonance imaging (MRI) and dual X-ray absorptiometry (DXA). SUBJECTS/METHODS: One hundred and thirty-six healthy Caucasian adults (70 men, 66 women; age 40±12 years) were measured by a phase-sensitive multifrequency BIA (seca medical body composition analyzers 515 and 525)...
March 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28327087/nt5c2-novel-splicing-variant-expands-the-phenotypic-spectrum-of-spastic-paraplegia-spg45-case-report-of-a-new-member-of-thin-corpus-callosum-spg-subgroup
#3
Mahmoud F Elsaid, Khalid Ibrahim, Nader Chalhoub, Ahmed Elsotouhy, Noora El Mudehki, Alice Abdel Aleem
BACKGROUND: Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of neurodegenerative diseases. Thin Corpus Callosum (TCC) associated HSP is a distinguished subgroup of complex forms. Purines and pyrimidine, the basic DNA and RNA components, are regulating the cell metabolism, having roles in signal transduction, energy preservation and cellular repair. Genetic defects in nucleotide metabolism related genes have been only recently implicated in brain and neurodegenerative diseases' pathogenesis...
March 21, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28323929/human-brown-adipose-tissue-temperature-and-fat-fraction-are-related-to-its-metabolic-activity
#4
Kalle Koskensalo, Juho Raiko, Teemu Saari, Virva Saunavaara, Olli Eskola, Pirjo Nuutila, Jani Saunavaara, Riitta Parkkola, Kirsi A Virtanen
Background and aim: The metabolic activity of human brown adipose tissue (BAT) has been previously examined using positron-emission-tomography (PET). The aim of this study was to use proton Magnetic Resonance Spectroscopy (1H MRS) to investigate whether the temperature and the fat fraction (FF) of brown and white adipose tissue (WAT) are associated with BAT metabolic activity determined by 18F-FDG-PET. Materials and methods: Ten healthy subjects (4f/6m, 25-45 y) were studied using PET-MRI during acute cold exposure and at ambient room temperature...
February 21, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28317080/the-critical-role-of-imaging-in-the-management-of-multiple-myeloma
#5
REVIEW
Shahzad Raza, Siyang Leng, Suzanne Lentzsch
Multiple myeloma (MM) is characterized by abnormal proliferation of plasma cells in the bone marrow leading to symptoms of anemia, renal failure, hypercalcemia, and bone lesions. Bone imaging is critical for the diagnosis, staging, assessment for the presence and extent of bone lesions, and initial treatment of MM. Skeletal survey is the preferred initial imaging modality due to its availability and low cost. However, it has poor sensitivity and patients with occult myeloma may escape detection, delaying their diagnosis and treatment...
March 20, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28315917/a-pediatric-hypophosphatemic-rickets-on-mri-99m-tc-mdp-bone-scan-and-18-f-fdg-pet-ct
#6
Changyun Xu, Chao Ma, Yongli Bai
We present a case of a 13 years old boy who was hospitalized with a 10 months history of progressive pain and weakness in his lower extremities. The laboratory tests revealed slightly decreased phosphate and 25-hydroxyvitamin D3, high alkaline phosphatase, normal calcium and parathyroid hormone (PTH). Magnetic resonance imaging (MRI) showed multiple patchy lesions indicating bone destruction in the metaphyses and epiphyses of the left knee. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) revealed a generalized decrease of bone density in axial bones with slightly increased (18)F-FDG metabolism...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28298968/feasibility-of-imaging-superficial-palmar-arch-using-micro-ultrasound-7t-and-3t-magnetic-resonance-imaging
#7
Alison N Pruzan, Audrey E Kaufman, Claudia Calcagno, Yu Zhou, Zahi A Fayad, Venkatesh Mani
AIM: To demonstrate feasibility of vessel wall imaging of the superficial palmar arch using high frequency micro-ultrasound, 7T and 3T magnetic resonance imaging (MRI). METHODS: Four subjects (ages 22-50 years) were scanned on a micro-ultrasound system with a 45-MHz transducer (Vevo 2100, VisualSonics). Subjects' hands were then imaged on a 3T clinical MR scanner (Siemens Biograph MMR) using an 8-channel special purpose phased array carotid coil. Lastly, subjects' hands were imaged on a 7T clinical MR scanner (Siemens Magnetom 7T Whole Body Scanner) using a custom built 8-channel transmit receive carotid coil...
February 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28295775/comparative-study-of-conventional-and-virtual-autopsy-using-postmortem-mri-in-the-phenotypic-characterization-of-stillbirths-and-malformed-fetuses
#8
Mohan Shruthi, Neerja Gupta, Manisha Jana, Asit R Mridha, Atin Kumar, Ramesh Agarwal, Raju Sharma, Dipika Deka, Arun Kumar Gupta, Madhulika Kabra
OBJECTIVE: To prospectively compare conventional and virtual autopsy using postmortem-MRI in the phenotypic characterization of stillbirths and malformed fetuses and their acceptability to parents. METHODS: We performed whole body postmortem-MRI (1.5T) prior to conventional autopsy in 43 fetuses/still births (≥20 weeks of gestation) after excluding maternal causes of fetal death. With conventional autopsy as gold standard, postmortem-MRI findings were assessed and compared...
March 13, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28289935/repeated-intravenous-administration-of-gadobutrol-does-not-lead-to-increased-signal-intensity-on-unenhanced-t1-weighted-images-a-voxel-based-whole-brain-analysis
#9
Soenke Langner, Marie-Luise Kromrey, Jens-Peter Kuehn, Matthias Grothe, Martin Domin
OBJECTIVES: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis. METHODS: In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28289855/whole-body-mri-dynamic-contrast-enhanced-mri-and-diffusion-weighted-imaging-for-the-staging-of-multiple-myeloma
#10
REVIEW
Julie C Dutoit, Koenraad L Verstraete
Magnetic resonance imaging (MRI) is the most sensitive imaging technique for the detection of bone marrow infiltration, and has therefore recently been included in the new diagnostic myeloma criteria, as proposed by the International Myeloma Working Group. Nevertheless, conventional MRI only provides anatomical information and is therefore only of limited use in the response assessment of patients with multiple myeloma. The additional information from functional MRI techniques, such as diffusion-weighted imaging and dynamic contrast-enhanced MRI, can improve the detection rate of bone marrow infiltration and the assessment of response...
March 13, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28288466/quantitative-assessment-of-trunk-muscles-involvement-in-patients-with-myotonic-dystrophy-type-1-using-a-whole-body-muscle-magnetic-resonance-imaging
#11
Donghwi Park, Jin-Sung Park
OBJECTIVE: The aim of this study was to analyze the pattern of trunk muscles involvement through a muscle MRI, in relation to the clinical data of patients diagnosed with myotonic dystrophy type 1 (DM1). MATERIALS AND METHODS: Patients with DM1 who visited the neurology department were enrolled (n = 19). In all patients, the fatty degeneration of the muscle MRI in the lower cervical, upper thoracic, middle thoracic, and lumbosacral spine extensor muscle group and trunk flexor muscle group was evaluated...
March 14, 2017: European Neurology
https://www.readbyqxmd.com/read/28285653/the-use-of-magnetic-resonance-imaging-to-characterize-abnormal-body-composition-phenotypes-in-youth-with-prader-willi-syndrome
#12
Camila E Orsso, Michelle Mackenzie, Angela S Alberga, Arya M Sharma, Lawrence Richer, Daniela A Rubin, Carla M Prado, Andrea M Haqq
INTRODUCTION: Magnetic resonance imaging (MRI) provides detailed assessment of body composition compartments. No studies have employed state-of-the-art MRI methods to accurately examine abdominal adipose tissue (AT) and skeletal muscle in youth with Prader-Willi syndrome (PWS). Therefore, this study aimed to describe AT distribution and skeletal muscle in the abdominal region of youth with PWS using MRI. METHODS: Anthropometric measures and whole-abdominal T1-weighted MRI were performed in sixteen (5 males and 11 females) youth diagnosed with PWS, and seventeen (10 males and 7 females) youth who did not have PWS (controls)...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28282998/non-traumatic-vertebral-lesions-incremental-utility-of-pet-ct-over-mri-and-fnac-in-a-suggested-diagnostic-algorithm
#13
Rajesh Meena, Ashish Aggarwal, Anish Bhattacharya, Vivek Gupta, Sivashanmugam Dhandapani, Rajesh Chhabra
OBJECTIVE: To prospectively compare positron emission tomography-computed tomography (PET-CT) with conventional magnetic resonance imaging (MRI) and FNAC for diagnosis of non- traumatic vertebral lesions fracture in countries like India where tuberculosis is endemic. METHODS: Fifty four patients with non-traumatic spontaneous vertebral lesions were prospectively studied. All patients underwent CEMRI focusing on the spinal lesions, whole-body PET-CT and FNAC.Results were then analysed and compared with final diagnosis obtained either by FNAC or clinical follow up...
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28282807/radiological-pathological-correlation-in-alzheimer-s-disease-systematic-review-of-antemortem-magnetic-resonance-imaging-findings
#14
Caroline Dallaire-Théroux, Brandy L Callahan, Olivier Potvin, Stéphan Saikali, Simon Duchesne
BACKGROUND: The standard method of ascertaining Alzheimer's disease (AD) remains postmortem assessment of amyloid plaques and neurofibrillary degeneration. Vascular pathology, Lewy bodies, TDP-43, and hippocampal sclerosis are frequent comorbidities. There is therefore a need for biomarkers that can assess these etiologies and provide a diagnosis in vivo. OBJECTIVE: We conducted a systematic review of published radiological-pathological correlation studies to determine the relationship between antemortem magnetic resonance imaging (MRI) and neuropathological findings in AD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28280965/radiosynthesis-and-first-in-human-pet-mri-evaluation-with-clinical-grade-18-f-ftc-146
#15
Bin Shen, Jun Hyung Park, Trine Hjørnevik, Peter W Cipriano, Daehyun Yoon, Praveen K Gulaka, Dawn Holly, Deepak Behera, Bonnie A Avery, Sanjiv S Gambhir, Christopher R McCurdy, Sandip Biswal, Frederick T Chin
PURPOSE: Sigma-1 receptors (S1Rs) play an important role in many neurological disorders. Simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) with S1R radioligands may provide valuable information for diagnosing and guiding treatment for these diseases. Our previously reported S1R radioligand, [(18)F]FTC-146, demonstrated high affinity for the S1R (K i = 0.0025 nM) and excellent selectivity for the S1R over the sigma-2 receptor (S2Rs; K i = 364 nM) across several species (from mouse to non-human primate)...
March 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28273651/comparative-preclinical-evaluation-of-68-ga-nodaga-and-68-ga-hbed-cc-conjugated-procainamide-in-melanoma-imaging
#16
György Trencsényi, Noémi Dénes, Gábor Nagy, Adrienn Kis, András Vida, Flóra Farkas, Judit P Szabó, Tünde Kovács, Ervin Berényi, Ildikó Garai, Péter Bai, János Hunyadi, István Kertész
Malignant melanoma is the most aggressive form of skin cancer. The early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of this disease. Previous studies have shown that benzamide derivatives (e.g. procainamide) conjugated with PET radionuclides specifically bind to melanin pigment of melanoma tumors. (68)Ga chelating agents can have high influence on physiological properties of (68)Ga labeled bioactive molecules, as was experienced during the application of HBED-CC on PSMA ligand...
March 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28270293/bone-marrow-imaging-by-third-generation-dual-source-dual-energy-ct-using-virtual-noncalcium-technique-for-assessment-of-diffuse-infiltrative-lesions-of-multiple-myeloma
#17
Qin Wang, Zhaoyong Sun, Shuo Li, Haibo Zhang, Jian Li, L U Zhang, Huadan Xue, Zhengyu Jin
Objective To evaluate the value of bone marrow imaging by third-generation dual-source dual-energy CT(DSDECT) using virtual noncalcium(VNCa) technique for the assessment of diffuse infiltrative lesions of multiple myeloma(MM). Methods From December 2015 to June 2016,31 patients with plasma disorders at our center were prospectively recruited and received whole-body imaging with third-generation DSDECT and MRI. CT numbers of vertebrae were measured on VNCa images as well as regular CT images. Correlation between VNCa CT numbers and MRI signal intensities of the vertebrae was evaluated...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28269680/effects-of-coplanar-shielding-for-high-field-mri
#18
Joseph V Rispoli, Matthew D Wilcox, Samantha By, Steven M Wright, Mary P McDougall
This work investigates the efficacy of "coplanar shielding," in which copper shields are oriented concentric and coplanar to the RF coils rather than implemented as a full ground plane behind them. Following FDTD simulations to determine optimal shielding parameters, two coil geometries were constructed: a circular loop surface coil and a half-volume five-element receive array. Each was evaluated using bench measurements with and without coplanar shielding. Imaging, including accelerated SENSE imaging, was performed with the shielded and unshielded receive arrays on a whole-body 7T scanner...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267530/evaluation-of-pet-and-mr-datasets-in-integrated-18f-fdg-pet-mri-a-comparison-of-different-mr-sequences-for-whole-body-restaging-of-breast-cancer-patients
#19
Johannes Grueneisen, Lino Morris Sawicki, Axel Wetter, Julian Kirchner, Sonja Kinner, Bahriye Aktas, Michael Forsting, Verena Ruhlmann, Lale Umutlu
OBJECTIVES: To investigate the diagnostic value of different MR sequences and 18F-FDG PET data for whole-body restaging of breast cancer patients utilizing PET/MRI. METHODS: A total of 36 patients with suspected tumor recurrence of breast cancer based on clinical follow-up or abnormal findings in follow-up examinations (e.g. CT, MRI) were prospectively enrolled in this study. All patients underwent a PET/CT and subsequently an additional PET/MR scan. Two readers were instructed to identify the occurrence of a tumor relapse in subsequent MR and PET/MR readings, utilizing different MR sequence constellations for each session...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28262561/non-uniformly-weighted-sampling-for-faster-localized-two-dimensional-correlated-spectroscopy-of-the-brain-in-vivo
#20
Gaurav Verma, Sanjeev Chawla, Rajakumar Nagarajan, Zohaib Iqbal, M Albert Thomas, Harish Poptani
Two-dimensional localized correlated spectroscopy (2D L-COSY) offers greater spectral dispersion than conventional one-dimensional (1D) MRS techniques, yet long acquisition times and limited post-processing support have slowed its clinical adoption. Improving acquisition efficiency and developing versatile post-processing techniques can bolster the clinical viability of 2D MRS. The purpose of this study was to implement a non-uniformly weighted sampling (NUWS) scheme for faster acquisition of 2D-MRS. A NUWS 2D L-COSY sequence was developed for 7T whole-body MRI...
February 22, 2017: Journal of Magnetic Resonance
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