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Whole body MRI

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https://www.readbyqxmd.com/read/28535000/staging-performance-of-whole-body-dwi-pet-ct-and-pet-mri-in-invasive-ductal-carcinoma-of-the-breast
#1
Onofrio Antonio Catalano, Dania Daye, Alberto Signore, Carlo Iannace, Mark Vangel, Angelo Luongo, Marco Catalano, Mazzeo Filomena, Luigi Mansi, Andrea Soricelli, Marco Salvatore, Niccolo Fuin, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
The aim of the present study was to evaluate the performance of whole-body diffusion-weighted imaging (WB-DWI), whole-body positron emission tomography with computed tomography (WB-PET/CT), and whole-body positron emission tomography with magnetic resonance imaging (WB-PET/MRI) in staging patients with untreated invasive ductal carcinoma of the breast. Fifty-one women with newly diagnosed invasive ductal carcinoma of the breast underwent WB-DWI, WB-PET/CT and WB-PET/MRI before treatment. A radiologist and a nuclear medicine physician reviewed in consensus the images from the three modalities and searched for occurrence, number and location of metastases...
May 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28534182/imaging-children-suffering-from-lymphoma-an-evaluation-of-different-18-f-fdg-pet-mri-protocols-compared-to-whole-body-dw-mri
#2
Julian Kirchner, Cornelius Deuschl, Bernd Schweiger, Ken Herrmann, Michael Forsting, Christian Buchbender, Gerald Antoch, Lale Umutlu
OBJECTIVES: The objectives of this study were to evaluate and compare the diagnostic potential of different PET/MRI reading protocols, entailing non-enhanced / contrast-enhanced and diffusion-weighted (18)F-FDG PET/MR imaging and whole-body diffusion-weighted MRI for lesion detection and determination of the tumor stage in pediatric lymphoma patients. METHODS: A total of 28 (18)F-FDG PET/MRI datasets were included for analysis of four different reading protocols: (1) PET/MRI utilizing sole unenhanced T2w and T1w imaging, (2) PET/MRI utilizing additional contrast enhanced sequences, (3) PET/MR imaging utilizing unenhanced, contrast enhanced and DW imaging or (4) WB-DW-MRI...
May 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533960/body-composition-estimation-from-selected-slices-equations-computed-from-a-new-semi-automatic-thresholding-method-developed-on-whole-body-ct%C3%A2-scans
#3
Alizé Lacoste Jeanson, Ján Dupej, Chiara Villa, Jaroslav Brůžek
BACKGROUND: Estimating volumes and masses of total body components is important for the study and treatment monitoring of nutrition and nutrition-related disorders, cancer, joint replacement, energy-expenditure and exercise physiology. While several equations have been offered for estimating total body components from MRI slices, no reliable and tested method exists for CT scans. For the first time, body composition data was derived from 41 high-resolution whole-body CT scans. From these data, we defined equations for estimating volumes and masses of total body AT and LT from corresponding tissue areas measured in selected CT scan slices...
2017: PeerJ
https://www.readbyqxmd.com/read/28533937/a-phase-one-single-dose-open-label-clinical-safety-and-pet-mr-imaging-study-of-68-ga-dotatoc-in-healthy-volunteers
#4
Shadi A Esfahani, Stephanie Salcedo, Pedram Heidari, Onofrio A Catalano, Rachel Pauplis, Jacob Hesterman, James F Kronauge, Umar Mahmood
This prospective pilot study provides a dynamic whole body PET/MR image database, clinical safety, biodistribution profile and dosimetry of (68)Ga-DOTATOC in healthy subjects, to establish a baseline and standard reference for its use in diagnosis and treatment response evaluation among patients with somatostatin receptor expressing neoplastic diseases. Dynamic whole body PET/MR imaging was performed in 12 healthy subjects (male/female: 8/4) after injection of 242.39 ± 53.38 MBq (mean ± SD) (68)Ga-DOTATOC...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28533654/psma-expression-in-multinodular-thyroid-neoplasm-on-simultaneous-ga-68-psma-pet-mri
#5
Amarnath Jena, Shuaib Zaidi, Vikas Kashyap, Abhishek Jha, Sangeeta Taneja
PSMA PET is increasingly being used in imaging of recurrent prostate carcinoma. A case with suspected recurrent Prostate carcinoma (PCa), raised PSA (Prostate specific antigen) and suspected spinal metastases was referred for whole body Ga-68-PSMA PET/MRI. The study revealed PSMA avid recurrent prostate mass and extensive osseous metastases. Abnormal PSMA uptake in the thyroid gland prompted USG-guided FNAC which revealed Hurthle cell neoplasm. Histopathological examination (HPE) of excised gland showed multiple Hurthle cell adenomas in both lobes of thyroid along with foci of papillary thyroid carcinoma which on immunohistochemistry were thyroglobulin positive and PSA negative...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28529065/brown-adipose-tissue-and-lipid-metabolism-imaging
#6
REVIEW
Andreas Paulus, Wouter van Marken Lichtenbelt, Felix M Mottaghy, Matthias Bauwens
PURPOSE: Brown adipose tissue (BAT) research has evolved from an underestimated to a fast developing field. Its assumed curing properties for the world wide epidemic obesity, and its related diseases, makes this tissue an interesting target for a broad amount of non-invasive molecular BAT tracers. Apart from (18)F-FDG PET/CT there are several methods to detect BAT and measure its metabolism in a more appropriate way. Especially interesting is the measure of lipid turnover, because fatty acids comprise the main fuel for active BAT...
May 18, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28528897/lateral-lumbar-interbody-fusion-at-the-lumbosacral-junction
#7
Timothy L T Siu, Kainu Lin
Due to the obstruction of the iliac crest and the retroperitoneal vessels, lateral lumbar interbody fusion (LLIF) is generally considered contraindicated at the lumbosacral junction (LSJ). In particular the 'rise' of the psoas from the vertebral column in the lower lumbar segments has been associated with significant overlap of the lumbar plexus with the vertebral body and exclusion of a safe transpsoas entry. However in selected individuals anatomical variations may help circumvent the difficulties and the anatomical corridor posterior to the lumbar plexus may provide an alternative to the conventional anterior approach...
May 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28525448/18f-fluorocholine-pet-ct-complementing-the-role-of-dynamic-contrast-enhanced-mri-for-providing-comprehensive-diagnostic-workup-in-prostate-cancer-patients-with-suspected-relapse-following-radical-prostatectomy
#8
Shelvin Kumar Vadi, Baljinder Singh, Rajender K Basher, Ankit Watts, Ashwani K Sood, Anupam Lal, Nandita Kakkar, S K Singh
PURPOSE: The aim of this study was to compare the diagnostic performance of F-fluorocholine (FCH) PET/CT and dynamic contrast-enhanced MRI (DCE-MRI) of pelvis in restaging prostate cancer (PC) patients with biochemical recurrence (BCR) following radical prostatectomy (RP). METHODS: Twenty PC patients who had undergone RP and had BCR were recruited in this study. All the patients underwent whole-body FCH PET/CT and DCE-MRI of the pelvis. An overall pattern of recurrent disease was analyzed, and diagnostic accuracy for the detection of pelvic disease recurrence by the 2 modalities was evaluated by taking histopathologic analysis as the criterion standard...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28520813/pancreatic-fat-content-by-magnetic-resonance-imaging-in-subjects-with-prediabetes-diabetes-and-controls-from-a-general-population-without-cardiovascular-disease
#9
Sophia D Heber, Holger Hetterich, Roberto Lorbeer, Christian Bayerl, Jürgen Machann, Sigrid Auweter, Corinna Storz, Christopher L Schlett, Konstantin Nikolaou, Maximilian Reiser, Annette Peters, Fabian Bamberg
BACKGROUND/OBJECTIVE: Despite the relevance of pancreatic fat content in the development of metabolic diseases, its association with impaired glucose metabolism, diabetes, and other adipose tissue compartments remains unclear. Thus, we determined differences in pancreatic fat content by magnetic resonance imaging (MRI) between subjects with prediabetes, diabetes, and normal controls in a cohort from the general population. METHODS: Subjects without history of cardiovascular disease with established diabetes or prediabetes as well as normal controls were included and underwent whole-body MRI on a 3T scanner...
2017: PloS One
https://www.readbyqxmd.com/read/28516052/whole-body-mri-of-the-non-human-primate-using-a-clinical-3t-scanner-initial-experiences
#10
Chun-Xia Li, Xiaodong Zhang
With the advent of parallel imaging MRI techniques, whole-body MRI is being increasingly used in clinical diagnosis. However, its application in preclinical research using large animals remains very limited. In the present study, the whole-body MRI techniques for adult macaque monkeys were explored using a conventional clinic 3T scanner. The T1, T2 anatomical images, and MR angiography of adult macaque whole bodies were illustrated. The preliminary results suggest whole-body MRI can be a robust tool to examine multiple organs of non-human primate (NHP) models from head to toe non-invasively and simultaneously using a conventional clinical setting...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28516042/sensitivity-enhancement-of-traveling-wave-mri-using-free-local-resonators-an-experimental-demonstration
#11
Xiaoliang Zhang
BACKGROUND: Traveling wave MR uses the far fields in signal excitation and reception, therefore its acquisition efficiency is low in contrast to the conventional near field magnetic resonance (MR). Here we show a simple and efficient method based on the local resonator to improving sensitivity of traveling wave MR technique. The proposed method utilizes a standalone or free local resonator to amplify the radio frequency magnetic fields in the interested target. The resonators have no wire connections to the MR system and thus can be conveniently placed to any place around imaging simples...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28514760/clinical-study-of-99mtc-3p-rgd2-peptide-imaging-in-osteolytic-bone-metastasis
#12
Guoqiang Shao, Wei Gu, Muhong Guo, Shiming Zang, Jinjing Fu, Shuang Liu, Feng Wang, Zizheng Wang
OBJECTIVE: To investigate the value of integrin αvβ3 targeted imaging with 99mTc-HYNIC-PEG4-E[PEG4-c(RGDfk)]2 (99mTc-3P-RGD2) as a radiotracer in dectecting osteolytic bone metastases. METHODS: This is a retrospective study involving a cohort of 69 consecutive patients including 59 with lung cancer and 10 with other cancers. Patients were required to receive whole body scan (WBS) and regional SPECT/CT imaging with 99mTc-3P-RGD2 (RGD imaging) and 99mTc-MDP (MDP imaging) as a radiotracer successively within days...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28506521/role-of-imaging-in-response-assessment-and-individualised-treatment-for-sarcomas
#13
H Choi
The first systematic response evaluation criteria were established by WHO, based on the tumor size changes shortly after the computed tomography (CT) technique became available to the daily practice. RECIST, a simplified version of WHO criteria, and its newer version, RECIST1.1 are the currently available international response evaluation criteria in solid tumors and remains based on tumor size changes. While the introduction of molecularly targeted drugs has significantly improved the survival in patient with sarcomas, the evaluation of tumor response has become more complicated...
May 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28499601/multicomponent-nanocrystals-with-anti-stokes-luminescence-as-contrast-agents-for-modern-imaging-techniques
#14
REVIEW
A N Generalova, B N Chichkov, E V Khaydukov
Lanthanide-doped upconversion nanoparticles (UCNPs) have recently attracted great attention in theranostics due to their exceptional optical and physicochemical properties, which enable the design of a novel UCNP-based nanoplatform for luminescent imaging, temperature mapping, sensing, and therapy. In addition, UCNPs are considered to be ideal building blocks for development of multimodal probes for cells and whole body imaging, exploiting simple variation of host matrix, dopant ions, and surface chemistry...
May 4, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28486936/effects-of-inaccuracies-in-arterial-path-length-measurement-on-differences-in-mri-and-tonometry-measured-pulse-wave-velocity
#15
Jonathan R Weir-McCall, Faisel Khan, Deirdre B Cassidy, Arsh Thakur, Jennifer Summersgill, Shona Z Matthew, Fiona Adams, Fiona Dove, Stephen J Gandy, Helen M Colhoun, Jill Jf Belch, J Graeme Houston
BACKGROUND: Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to evaluate whether the differences between cf.-PWV and MRI-PWV can be accounted for by inaccuracies of currently used distance measurements. METHODS: One hundred fourteen study participants were recruited into one of 4 groups: Type 2 diabetes melltus (T2DM) with cardiovascular disease (CVD) (n = 23), T2DM without CVD (n = 41), CVD without T2DM (n = 25) and a control group (n = 25)...
May 10, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28484627/the-chinchilla-as-a-novel-animal-model-of-pregnancy
#16
Emmeli Mikkelsen, Henrik Lauridsen, Per Mose Nielsen, Haiyun Qi, Thomas Nørlinger, Maria Dahl Andersen, Niels Uldbjerg, Christoffer Laustsen, Puk Sandager, Michael Pedersen
Several parameters are important when choosing the most appropriate animal to model human obstetrics, including gestation period, number of fetuses per gestation and placental structure. The domesticated long-tailed chinchilla (Chinchilla lanigera) is a well-suited and appropriate animal model of pregnancy that often will carry only one offspring and has a long gestation period of 105-115 days. Furthermore, the chinchilla placenta is of the haemomonochorial labyrinthine type and is therefore comparable to the human villous haemomonochorial placenta...
April 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28484299/radiologic-diagnosis-of-spondylodiscitis-role-of-magnetic-resonance
#17
Naser Ramadani, Kreshnike Dedushi, Serbeze Kabashi, Sefedin Mucaj
INTRODUCTION: Study aim is to report the Magnetic Resonance Imaging (MRI) features of acute and chronic spontaneous spondylodiscitis. CASE REPORT: 57 year old female, complaining of a fever and longstanding cervical pain worsened during physical therapy. METHODS: MR images were acquired using superconductive magnet 1.5 T, with the following sequences: sagittal PD and T2 TSE, sagittal T1 SE, axial PD and T2 TSE (lumbar spine), axial T2 GRE (cervical spine)...
March 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28481336/association-between-individual-fat-depots-and-cardio-metabolic-traits-in-normal-and-overweight-children-adolescents-and-adults
#18
M Hübers, C Geisler, S Plachta-Danielzik, M J Müller
OBJECTIVES: To determine age-related associations between fat mass (FM), regional fat depots and cardiometabolic traits in normal- and overweight children, adolescents and adults. METHODS: Detailed body composition (regional subcutaneous and visceral adipose tissue; SAT, VAT) by whole-body magnetic resonance imaging (MRI), FM and fat-free mass by air-displacement plethysmography, systolic and diastolic blood pressure (SBP, DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL), plasma glucose and plasma insulin were measured in 433 subjects (BMI: 23...
May 8, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28479217/physiological-and-psychological-effects-of-testosterone-during-severe-energy-deficit-and-recovery-a-study-protocol-for-a-randomized-placebo-controlled-trial-for-optimizing-performance-for-soldiers-ops
#19
Stefan M Pasiakos, Claire E Berryman, J Philip Karl, Harris R Lieberman, Jeb S Orr, Lee M Margolis, John A Caldwell, Andrew J Young, Monty A Montano, William J Evans, Oshin Vartanian, Owen T Carmichael, Kishore M Gadde, Melissa Harris, Jennifer C Rood
BACKGROUND: The physiological consequences of severe energy deficit include hypogonadism and the loss of fat-free mass. Prolonged energy deficit also impacts physical performance, mood, attentiveness, and decision-making capabilities. This study will determine whether maintaining a eugonadal state during severe, sustained energy deficit attenuates physiological decrements and maintains mental performance. This study will also assess the effects of normalizing testosterone levels during severe energy deficit and recovery on gut health and appetite regulation...
May 4, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28474256/pediatric-imaging-in-dicer1-syndrome
#20
Marta Tijerin Bueno, Claudia Martínez-Ríos, Alejandro De la Puente Gregorio, Rayan A Ahyad, Anita Villani, Harriet Druker, Kalene van Engelen, Bailey Gallinger, Laura Aronoff, Ronald Grant, David Malkin, Mary-Louise C Greer
BACKGROUND: DICER1 syndrome, arising from a mutation in the DICER1 gene mapped to chromosome 14q32, is associated with an increased risk of a range of benign and malignant neoplasms. OBJECTIVE: To determine the spectrum of abnormalities and imaging characteristics in patients with DICER1 syndrome at a tertiary pediatric hospital. MATERIALS AND METHODS: This retrospective analysis evaluated imaging in patients ≤18 years with DICER1 germline variants between January 2004 and July 2016...
May 4, 2017: Pediatric Radiology
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