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Whole body MRI

Robert Smigiel, Gerd Landsberg, Maximilian Schilling, Małgorzata Rydzanicz, Agnieszka Pollak, Anna Walczak, Anna Stodolak, Piotr Stawinski, Hanna Mierzewska, Maria M Sasiadek, Oliver J Gruss, Rafal Ploski
PTPN23 encodes a ubiquitously expressed non-receptor type, catalytically inactive protein-tyrosine phosphatase found in all cells including neurons. Recently, we have identified PTPN23 in a cellular screen for the systematic identification of novel regulators of survival motor neuron (SMN) function in the assembly of splicing factors (Uridine-rich small nuclear ribonucleoproteins, UsnRNPs). Based on three families, recessive PTPN23 variants have been associated with human disease tentatively, without functional studies...
June 13, 2018: European Journal of Human Genetics: EJHG
Qi Zeng, Qingyan Wang, Jianfeng Jason Zheng, Wolfgang Kainz, Ji Chen
A typical cochlear implant system under Magnetic Resonance Imaging (MRI) procedures may couple with the radio frequency (RF) electromagnetic field (EMF) and results in an intensified electric field at the lead tip. As a result, the RF energy deposited in human tissues around the lead tip may induce heating and cause tissue damage concerns. The purpose of this work is to evaluate the RF-EMF-induced heating for cochlear implant system in 1.5T MRI coil and highlight the factors that have significant effects on the heating...
June 12, 2018: Physics in Medicine and Biology
Meg F Bobo, Shunxing Bao, Yuankai Huo, Yuang Yao, Jack Virostko, Andrew J Plassard, Ilwoo Lyu, Albert Assad, Richard G Abramson, Melissa A Hilmes, Bennett A Landman
Abdominal image segmentation is a challenging, yet important clinical problem. Variations in body size, position, and relative organ positions greatly complicate the segmentation process. Historically, multi-atlas methods have achieved leading results across imaging modalities and anatomical targets. However, deep learning is rapidly overtaking classical approaches for image segmentation. Recently, Zhou et al. showed that fully convolutional networks produce excellent results in abdominal organ segmentation of computed tomography (CT) scans...
March 2018: Proceedings of SPIE
Bert-Ram Sah, Soleen Ghafoor, Irene A Burger, Edwin E G W Ter Voert, Tetsuro Sekine, Gaspar Delso, Martin Huellner, Konstantin Dedes, Andreas Boss, Patrick Veit-Haibach
Rationale: The goal of this study was to determine the level of clinically acceptable 18 F-fluoro-2-deoxy-D-glucose (18 F-FDG) dose reduction in time of flight (TOF) - positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with breast cancer. Methods: Twenty-six consecutive female patients with histologically proven breast cancer were analyzed (median age, 51 years; range, 34 - 83 years). Simulated dose-reduced PET images were generated by un-listing the list mode data on PET/MRI. The acquired 20 minutes PET frame was reconstructed in 5 ways: a reconstruction of the first 2 minutes with 3 iterations and 28 subsets for reference, and reconstructions simulating 100%, 20%, 10%, 5% of the original dose...
June 7, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Kristen A Wangerin, Lucia Baratto, Mohammad Mehdi Khalighi, Thomas A Hope, Praveen K Gulaka, Timothy W Deller, Andrei H Iagaru
OBJECTIVE: Gallium-68-labeled radiopharmaceuticals pose a challenge for scatter estimation because their targeted nature can produce high contrast in these regions of the kidneys and bladder. Even small errors in the scatter estimate can result in washout artifacts. Administration of diuretics can reduce these artifacts, but they may result in adverse events. Here, we investigated the ability of algorithmic modifications to mitigate washout artifacts and eliminate the need for diuretics or other interventions...
June 6, 2018: AJR. American Journal of Roentgenology
Gemma C Monté-Rubio, Carles Falcón, Edith Pomarol-Clotet, John Ashburner
There is a widespread interest in applying pattern recognition methods to anatomical neuroimaging data, but so far, there has been relatively little investigation into how best to derive image features in order to make the most accurate predictions. In this work, a Gaussian Process machine learning approach was used for predicting age, gender and body mass index (BMI) of subjects in the IXI dataset, as well as age, gender and diagnostic status using the ABIDE and COBRE datasets. MRI data were segmented and aligned using SPM12, and a variety of feature representations were derived from this preprocessing...
June 1, 2018: NeuroImage
Markus Wennmann, Laurent Kintzelé, Marie Piraud, Bjoern H Menze, Thomas Hielscher, Johannes Hofmanninger, Barbara Wagner, Hans-Ulrich Kauczor, Maximilian Merz, Jens Hillengass, Georg Langs, Marc-André Weber
The purpose of this study was to improve risk stratification of smoldering multiple myeloma patients, introducing new 3D-volumetry based imaging biomarkers derived from whole-body MRI. Two-hundred twenty whole-body MRIs from 63 patients with smoldering multiple myeloma were retrospectively analyzed and all focal lesions >5mm were manually segmented for volume quantification. The imaging biomarkers total tumor volume, speed of growth (development of the total tumor volume over time), number of focal lesions, development of the number of focal lesions over time and the recent imaging biomarker '>1 focal lesion' of the International Myeloma Working Group were compared, taking 2-year progression rate, sensitivity and false positive rate into account...
May 18, 2018: Oncotarget
Lihi Eder, Sibel Z Aydin, Gurjit S Kaeley, Walter P Maksymowych, Mikkel Østergaard
Psoriatic arthritis (PsA) is a heterogeneous disease with various manifestations of musculoskeletal inflammation. Recent advances in imaging, including ultrasound (US) and magnetic resonance imaging (MRI), allow for the accurate evaluation of the extent of inflammation and damage in the peripheral joints, spine, and entheses. The development and validation of outcome measures are critical steps in creating standardized evaluations of musculoskeletal inflammation and damage in psoriatic patients. At the 2017 meeting of the Group for Research and Assessment of Psoriasis and PsA (GRAPPA), recent work on outcome measures from the GRAPPA US and MRI working groups was summarized...
June 2018: Journal of Rheumatology. Supplement
Deepika Bagga, Christoph Stefan Aigner, Johanna Louise Reichert, Cinzia Cecchetto, Florian Ph S Fischmeister, Peter Holzer, Christine Moissl-Eichinger, Veronika Schöpf
PURPOSE: Experimental investigations in rodents have contributed significantly to our current understanding of the potential importance of the gut microbiome and brain interactions for neurotransmitter expression, neurodevelopment, and behaviour. However, clinical evidence to support such interactions is still scarce. The present study used a double-blind, randomized, pre- and post-intervention assessment design to investigate the effects of a 4-week multi-strain probiotic administration on whole-brain functional and structural connectivity in healthy volunteers...
May 30, 2018: European Journal of Nutrition
Anna M Sailer, Frans C Bakers, Jan W Daemen, Stefan Vöö
We report a case where an integrated whole body 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/magnetic resonance imaging (MRI) is performed in the diagnostic work-up of a saccular aortic aneurysm. The integrated whole body 18 F-FDG PET/MRI study answered all relevant diagnostic questions, clearly marking an infected aortic aneurysm, depicting the extent of the infected area in relation to the aortic branch vessels, and indicating the aortic lesion as the primary site of infection. The patient was successfully treated by open type V TAAA repair and pericardial graft replacement...
April 2018: Cardiovascular Diagnosis and Therapy
Kouhei Kamiya, Naohiro Okada, Kingo Sawada, Yusuke Watanabe, Ryusuke Irie, Shouhei Hanaoka, Yuichi Suzuki, Shinsuke Koike, Harushi Mori, Akira Kunimatsu, Masaaki Hori, Shigeki Aoki, Kiyoto Kasai, Osamu Abe
Major depressive disorder (MDD) is a globally prevalent psychiatric disorder that results from disruption of multiple neural circuits involved in emotional regulation. Although previous studies using diffusion tensor imaging (DTI) found smaller values of fractional anisotropy (FA) in the white matter, predominantly in the frontal lobe, of patients with MDD, studies using diffusion kurtosis imaging (DKI) are scarce. Here, we used DKI whole-brain analysis with tract-based spatial statistics (TBSS) to investigate the brain microstructural abnormalities in MDD...
May 30, 2018: NMR in Biomedicine
Luciana Audi Castroneves, George Coura Filho, Ricardo Miguel Costa de Freitas, Raphael Salles, Raquel Ajub Moyses, Rossana Veronica Mendoza Lopez, Maria Adelaide Albergaria Pereira, Marcos Roberto Tavares, Alexsander Augusto de Lima Jorge, Carlos Alberto Buchpiguel, Ana Oliveira Hoff
Objective: Evaluate the efficacy of 68Ga PET/CT in detecting MTC lesions and evaluate tumor expression of somatostatin receptors (SSTR) associating with 68Ga PET/CT findings. Methods: Prospective study evaluating 30 MTC patients; Group 1 (N=16): Biochemical disease and Group 2 (N=14): Metastatic disease. Patients underwent 68Ga PET/CT, bone scan, neck CT and US, CT chest, CT/MRI abdomen, MRI spine. 68Ga PET/CT findings were analyzed by disease site as positive or negative and as concordant or discordant with conventional studies...
May 28, 2018: Journal of Clinical Endocrinology and Metabolism
Lance E Davidson, Wen Yu, Bret H Goodpaster, James P DeLany, Elizabeth Widen, Thaisa Lemos, Gladys W Strain, Alfons Pomp, Anita P Courcoulas, Susan Lin, Isaiah Janumala, John C Thornton, Dympna Gallagher
OBJECTIVE: This study investigated changes in fat-free mass (FFM) and skeletal muscle 5 years after surgery in participants from the Longitudinal Assessment of Bariatric Surgery-2 trial. METHODS: A three-compartment model assessed FFM, and whole-body magnetic resonance imaging (MRI) quantified skeletal muscle mass prior to surgery (T0) and 1 year (T1), 2 years (T2), and 5 years (T5) postoperatively in 93 patients (85% female; 68% Caucasian; age 44.2 ± 11.6 years) who underwent gastric bypass (RYGB), sleeve gastrectomy, or adjustable gastric band...
May 30, 2018: Obesity
Laura Pasetto, Davide Olivari, Giovanni Nardo, Maria Chiara Trolese, Caterina Bendotti, Rosanna Piccirillo, Valentina Bonetto
Muscle wasting occurs during various chronic diseases and precedes death in humans as in mice. The evaluation of the degree of muscle atrophy in diseased mouse models is often overlooked since it requires the sacrifice of the animals for muscle examination or expensive instrumentation and highly qualified personnel, such as Magnetic Resonance Imaging (MRI). Very often behavioral tests for muscle strength evaluation are used as an outcome measurement in preclinical therapeutic trials. However, these tests are easy to perform serially, but not enough sensitive to detect early muscle changes during disease progression...
2018: PloS One
Adam E Hansen, Henrik Gutte, Pernille Holst, Helle H Johannesen, Sofie Rahbek, Andreas E Clemmensen, Majbritt M E Larsen, Christina Schøier, Jan Ardenkjaer-Larsen, Thomas L Klausen, Annemarie T Kristensen, Andreas Kjaer
13 C Magnetic Resonance Spectroscopy (MRS) using hyperpolarized 13 C-labeled pyruvate as a substrate offers a measure of pyruvate-lactate interconversion and is thereby a marker of the elevated aerobic glycolysis (Warburg effect) generally exhibited by cancer cells. Here, we aim to compare hyperpolarized [1-13 C]pyruvate MRS with simultaneous 18 F-2-fluoro-2-deoxy-d-glucose (FDG) PET in a cross-sectional study of canine cancer patients. METHODS: Canine cancer patients underwent integrated PET/MRI using a clinical whole-body system...
June 2018: European Journal of Radiology
Mickael Tordjman, Ivana Dabaj, Pascal Laforet, Adrien Felter, Ana Ferreiro, Moustafa Biyoukar, Bruno Law-Ye, Edmar Zanoteli, Claudia Castiglioni, John Rendu, Christophe Beroud, Alexandre Chamouni, Pascale Richard, Dominique Mompoint, Susana Quijano-Roy, Robert-Yves Carlier
OBJECTIVES: Inherited myopathies are major causes of muscle atrophy and are often characterized by rigid spine syndrome, a clinical feature designating patients with early spinal contractures. We aim to present a decision algorithm based on muscular whole body magnetic resonance imaging (mWB-MRI) as a unique tool to orientate the diagnosis of each inherited myopathy long before the genetically confirmed diagnosis. METHODS: This multicentre retrospective study enrolled 79 patients from referral centres in France, Brazil and Chile...
May 25, 2018: European Radiology
Omeed Mahrouyan, Øivind Tøien, Frank G Shellock
PURPOSE: The Temperature Logger Implant is a newly developed device that is capable of providing data for animal studies on thermoregulatory function, hibernation, hypothermia, and general health. During research, it may be necessary to conduct a magnetic resonance imaging (MRI) examination on an animal with this device implanted to assess anatomical changes or other conditions. Notably, this new device was specially designed to be unaffected by the electromagnetic fields used for MRI...
May 2018: Journal of Thermal Biology
Mark Thalgott, Charlotte Düwel, Isabel Rauscher, Matthias M Heck, Bernhard Haller, Andrei Gafita, Jürgen E Gschwend, Markus Schwaiger, Tobias Maurer, Matthias Eiber
Our aim was to assess the diagnostic potential of one-stop shop Prostate-specific membrane antigen-ligand Positron Emission Tomography/Magnetic Resonance Imaging (68 Ga-PSMA-11 PET/MRI) compared to preoperative staging nomograms in patients with high-risk prostate cancer (PC). Methods: A total of 102 patients underwent 68 Ga-PSMA-11 PET/MRI before intended radical prostatectomy (RP) with lymph node dissection. Preoperative variables determined the probabilities for lymph node metastases (LNM), extracapsular extension (ECE) and seminal vesical involvement (SVI) using the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram and Partin tables...
May 24, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
I Lavdas, A G Rockall, E Daulton, K Kozlowski, L Honeyfield, E O Aboagye, R Sharma
AIM: To evaluate apparent diffusion coefficient (ADC) histogram analysis parameters, acquired from whole-body diffusion-weighted magnetic resonance imaging (DW-MRI), as very early predictors of response to chemotherapy in patients with metastatic colorectal cancer (mCRC). MATERIALS AND METHODS: This was a single-institution prospective study, approved by the West Midlands-South Birmingham research ethics committee. All patients gave fully informed consent prior to imaging...
May 21, 2018: Clinical Radiology
Ana M Franceschi, Robert Matthews, Lev Bangiyev, Nand Relan, Ammar Chaudhry, Dinko Franceschi
OBJECTIVE: FDG PET/MRI examination of the body is routinely performed from the skull base to the mid thigh. Many types of brain abnormalities potentially could be detected on PET/MRI if the head was included. The objective of this study was therefore to identify and characterize brain findings incidentally detected on PET/MRI of the body with the head included. MATERIALS AND METHODS: We retrospectively identified 269 patients with FDG PET/MRI whole-body scans that included the head...
May 24, 2018: AJR. American Journal of Roentgenology
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