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Cardiac differentiation

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https://www.readbyqxmd.com/read/29913414/effect-of-%C3%AE-adrenergic-receptor-agents-on-cardiac-structure-and-function-and-whole-body-gene-expression-in-daphnia-magna
#1
Tae-Yong Jeong, Jana Asselman, Karel A C De Schamphelaere, Filip Van Nieuwerburgh, Dieter Deforce, Sang Don Kim
Propranolol (PRO), a human β-AR (β-adrenergic receptor) antagonist, is considered to result in specific effects in a non-target species, D. magna, based on our previous studies. The present study investigated the effects of β-AR agents, including an antagonist and agonist using pharmacologically relevant endpoints as well as a more holistic gene expression approach to reveal the impacts and potential mode of actions (MOAs) in the model non-target species. Results show that the responses in cardiac endpoints and gene expression in D...
June 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29912813/an-observational-cohort-feasibility-study-to-identify-microvesicle-and-micro-rna-biomarkers-of-acute-kidney-injury-following-pediatric-cardiac-surgery
#2
Nikol Sullo, Silvia Mariani, Maria JnTala, Tracy Kumar, Marcin J Woźniak, Dawn Smallwood, Paolo Pais, Claire Westrope, Attilio Lotto, Gavin J Murphy
OBJECTIVES: Micro-RNA, small noncoding RNA fragments involved in gene regulation, and microvesicles, membrane-bound particles less than 1 μm known to regulate cellular processes including responses to injury, may serve as disease-specific biomarkers of acute kidney injury. We evaluated the feasibility of measuring these signals as well as other known acute kidney injury biomarkers in a mixed pediatric cardiac surgery population. DESIGN: Single center prospective cohort feasibility study...
June 15, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29912202/suppression-of-pro-fibrotic-signaling-potentiates-factor-mediated-reprogramming-of-mouse-embryonic-fibroblasts-into-induced-cardiomyocytes
#3
Andrew S Riching, Yuanbiao Zhao, Yingqiong Cao, Pilar Londono, Hongyan Xu, Kunhua Song
Trans-differentiation of one somatic cell type into another has enormous potential to model and treat human diseases. Previous studies have shown that mouse embryonic, dermal, and cardiac fibroblasts can be reprogrammed into functional induced-cardiomyocyte-like cells (iCMs) through overexpression of cardiogenic transcription factors including GATA4, Hand2, Mef2c, and Tbx5 both in vitro and in vivo. However, these previous studies have shown relatively low efficiency. In order to restore heart function following injury, mechanisms governing cardiac reprogramming must be elucidated to increase efficiency and maturation of iCMs...
June 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29910675/differential-expression-of-circrnas-in-embryonic-heart-tissue-associated-with-ventricular-septal-defect
#4
Heng Liu, Yin Hu, Bin Zhuang, Jing Yin, Xiao-Hui Chen, Juan Wang, Meng-Meng Li, Jing Xu, Xing-Yun Wang, Zhang-Bin Yu, Shu-Ping Han
Objectives: To explore and validate the differential expression of circRNAs in the myocardium of congenital ventricular septal defect (VSD) and to explore a new avenue of research regarding the pathological mechanisms of VSD. Methods: We detected circRNAs expression profiles in heart tissues taken from six aborted fetuses with VSD and normal group using circRNA microarray. Some differentially expressed circRNAs were studied by bioinformatics analysis. Finally, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to confirm these results...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29909810/major-depression-impairs-incentive-processing-evidence-from-the-heart-and-the-face
#5
Jessica Franzen, Kerstin Brinkmann, Guido H E Gendolla, Othman Sentissi
BACKGROUND: The present study tested the hypothesis of a differential pattern of reward and punishment responsiveness in depression measuring effort mobilization during anticipation and facial expressions during consumption. METHODS: Twenty patients with major depressive disorder (MDD) and 20 control participants worked on a memory task under neutral, reward, and punishment instructions. Effort mobilization was operationalized as cardiovascular reactivity, while facial expressions were measured by facial electromyographic reactivity...
June 18, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29908831/a-new-method-for-neonatal-rat-ventricular-myocyte-purification-using-superparamagnetic-iron-oxide-particles
#6
Duomeng Yang, Junmin Xi, Yun Xing, Xiangxu Tang, Xiaomeng Dai, Kaiying Li, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang
BACKGROUND: Neonatal rat ventricular myocytes (NRVMs) have proven to be an ideal research model for cardiac disease. However, the current methods to purify NRVMs have a limitation to obtain high purity. The purpose of this study was to develop a NRVM purification method by using superparamagnetic iron oxide particles (SIOP). METHODS: NRVMs were purified by using SIOP (SIOP group). The differential attachment with or without bromodeoxyuridine (BrdU) treatment served as control and BrdU groups, respectively...
June 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29907457/what-may-the-future-hold-for-sports-cardiology
#7
REVIEW
André La Gerche, Aaron Baggish, Hein Heidbuchel, Benjamin D Levine, Dhrubo Rakhit
The field of sports cardiology has advanced significantly over recent times. It has incorporated clinical and research advances in cardiac imaging, electrophysiology and exercise physiology to enable better diagnostic and therapeutic management of our patients. One important endeavour has been to try and better differentiate athletic cardiac remodelling from inherited cardiomyopathies and other pathologies. Whilst our diagnostic tools have improved, there have also been errors resulting from assumptions that the pathological traits observed in the general population would be generalisable to athletic populations...
June 6, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29907121/position-of-draining-venous-cannula-in-extracorporeal-membrane-oxygenation-for-respiratory-and-respiratory-circulatory-support-in-adult-patients
#8
B Frenckner, M Broman, M Broomé
Extracorporeal membrane oxygenation (ECMO) is used in critically ill patients with severe pulmonary and/or cardiac failure. Blood is drained from the venous system and pumped through a membrane oxygenator where it is oxygenated. For pulmonary support, the blood is returned to the patient via a vein (veno-venous ECMO) and for pulmonary/circulatory support it is returned via an artery (veno-arterial ECMO).Veno-venous ECMO can be performed either with a single dual-lumen cannula or with two separate single-lumen cannulas...
June 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29906228/changes-in-cardiac-resident-fibroblast-physiology-and-phenotype-in-aging
#9
JoAnn Trial, Katarzyna A Cieslik
The cardiac fibroblast plays a central role in tissue homeostasis and in repair after injury. With aging, dysregulated cardiac fibroblasts have a reduced capacity to respond to transforming growth factor-β (TGF-β) and poorly differentiate into contractile myofibroblasts. That results in the formation of an insufficient scar after myocardial infarction (MI). By contrast, in the uninjured aged heart fibroblasts are activated and acquire a pro-fibrotic phenotype that leads to interstitial fibrosis, ventricular stiffness, and diastolic dysfunction, all conditions that may lead to heart failure...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905012/quantitative-secretomics-reveals-extrinsic-signals-involved-in-human-pluripotent-stem-cell-cardiomyogenesis
#10
Hanna Wolling, Sarah A Konze, Anne Höfer, Jelena Erdmann, Andreas Pich, Robert Zweigerdt, Falk F R Buettner
Human pluripotent stem cells (hPSCs) can be differentiated in vitro into cardiomyocytes (CMs) but the molecular mechanisms behind this process are still not fully understood. In particular identification of morphogens remained elusive because the mass spectrometry (MS)-based identification of secreted proteins from cell culture supernatants is impeded by high levels of albumin present in common differentiation media. Thus we established an albumin-free cardiomyogenic differentiation medium and performed secretomics at seven different time points during in vitro differentiation...
June 14, 2018: Proteomics
https://www.readbyqxmd.com/read/29904476/massive-mitral-annular-calcification-mimicking-intracardiac-mass-multimodality-approach-to-diagnosis
#11
Fabio Caruso, Luisa Ventura, Dafne Viliani, Sabino Walter Della Sala
The correct differential diagnosis of cardiac masses can be challenging and often carries important clinical implications. We present the case of a 78-year-old man with a cardiac mass of unclear etiology diagnosed on echocardiography. Using a multimodality approach with cardiac magnetic resonance and computed tomography, it was possible to define the real nature of the mass as composed of 2 voluminous calcifications of the mitral annulus.
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904415/tgf-%C3%AE-1-combined-with-sal-b-promotes-cardiomyocyte-differentiation-of-rat-mesenchymal-stem-cells
#12
Yang Lv, Bo Liu, Yuan Liu, Haoyu Wang, Haiping Wang
Transforming growth factor β1 (TGF-β1) and salvianolic acid B (Sal-B) are key signaling factors for stem cell differentiation into cardiomyocytes (CMs). The present study compared the biological effect of TGF-β1 and Sal-B, alone or in combination, on bone marrow mesenchymal stromal cells (BMSCs) that differentiate into myocardial-like cells in a simulated myocardial microenvironment in vitro . BMSCs were isolated from bones of limbs of 10 male Sprague Dawley rats and cultured. The 2nd-generation BMSCs were co-incubated with TGF-β1 and Sal-B, alone or in combination, for 72 h...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29902583/the-application-of-kinomic-array-analysis-to-screen-for-altered-kinases-in-atrial-fibrillation-remodeling
#13
Roelien A M Meijering, Marit Wiersma, Deli Zhang, Eva A H Lanters, Femke Hoogstra-Berends, Jetse Scholma, Sander Diks, XiaoYan Qi, Natasja M S de Groot, Stanley Nattel, Robert H Henning, Bianca J J M Brundel
BACKGROUND: Dysregulation of protein kinase-mediated signaling is an early event in many diseases, including the most common clinical cardiac arrhythmia, atrial fibrillation (AF). Kinomic profiling represents a promising technique to identify candidate kinases. OBJECTIVE: Here we employ kinomic profiling to identify kinases altered in AF remodeling using atrial tissue from a canine AF-model (atrial tachypacing). METHODS: Left atrial tissue obtained in a previous canine study was used for kinome array (containing 1024 kinase pseudo-substrates) analysis...
June 11, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29901190/curcumin-suppresses-cardiac-fibroblasts-activities-by-regulating-the-proliferation-and-cell-cycle-via-the-inhibition-of-the-p38-mapk-erk-signaling-pathway
#14
Guanhua Fang, Shaoqin Chen, Qiuyu Huang, Liangwan Chen, Dongshan Liao
Cardiac fibrosis is a deleterious effect of many cardiovascular diseases. Previous studies have shown that curcumin has exhibited protective effects on cardiovascular diseases. The aim of the present study was to evaluate the effects of curcumin on the activity of human cardiac fibroblasts (CFs) and to elucidate the underlying mechanisms involved. Human CFs were incubated with or without curcumin (20 µmol/l) and transforming growth factor β1 (TGF‑β1; 10 ng/ml), and the expression of α‑smooth muscle actin (α‑SMA), collagen type Iα (COLA)‑1 and COLA3 was evaluated using reverse transcription‑quantitative polymerase chain reaction and western blot analysis...
June 1, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900299/dataset-on-the-use-of-3d-speckle-tracking-echocardiography-in-light-chain-amyloidosis
#15
Antonio Vitarelli, Maria Teresa Petrucci, Silvia Lai, Carlo Gaudio, Lidia Capotosto, Enrico Mangieri, Serafino Ricci, Simone De Sio, Giovanni Truscelli, Federico Vozella, Mario Sergio Pergolini
The dataset presented in this article is related to the research article entitled "Biventricular assessment of light-chain amyloidosis using 3D speckle tracking echocardiography: Differentiation from other forms of myocardial hypertrophy" (Vitarelli et al., 2018) [1], which examined the potential utility of left ventricular (LV) and right ventricular (RV) deformation and rotational parameters derived from three-dimensional speckle-tracking echocardiography (3DSTE) to diagnose cardiac amyloidosis(CA) and differentiate this disease from other forms of myocardial hypertrophy...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29900007/use-of-integrated-imaging-and-serum-biomarker-profiles-to-identify-subclinical-dysfunction-in-pediatric-cancer-patients-treated-with-anthracyclines
#16
Olga H Toro-Salazar, Ji Hyun Lee, Kia N Zellars, Paige E Perreault, Kathryn C Mason, Zhu Wang, Kan N Hor, Eileen Gillan, Caroline J Zeiss, Daniel M Gatti, Brooke T Davey, Shelby Kutty, Bruce T Liang, Francis G Spinale
Background: Anthracycline induced cardiomyopathy is a major cause of mortality and morbidity among pediatric cancer survivors. It has been postulated that oxidative stress induction and inflammation may play a role in the pathogenesis of this process. Accordingly, the present study performed an assessment of biomarker profiles and functional imaging parameters focused upon potential early determinants of anthracycline induced cardiomyopathy. Methods: Patients (10-22 years) were prospectively enrolled between January 2013 and November 2014...
2018: Cardio-Oncology
https://www.readbyqxmd.com/read/29899566/gata-4-expressing-mouse-bone-marrow-mesenchymal-stem-cells-improve-cardiac-function-after-myocardial-infarction-via-secreted-exosomes
#17
Ji-Gang He, Hong-Rong Li, Jin-Xiu Han, Bei-Bei Li, Dan Yan, Hong-Yuan Li, Ping Wang, Ying Luo
This study aimed to investigate whether exosomes secreted by mouse GATA-4-expressing bone marrow mesenchymal stem cells (BMSCs) could induce BMSC differentiation into myocyte precursors, decrease cardiomyocyte apoptosis, and improve cardiac function following myocardial infarction (MI). BMSCs were transduced with a lentivirus carrying a doxycycline (DOX)-inducible GATA-4 or control lentivirus, and secreted exosomes from these BMSCs were collected and co-cultured with BMSCs or cardiomyocytes under hypoxic and serum free conditions...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898907/aortopulmonary-window-with-pumonary-atresia-with-ventricular-septal-defect-with-d-transposition-of-great-arteries-extremely-rare-anomaly
#18
Sachin Sondhi, P C Negi, Rajesh Sharma, Ayushi Mehta
Aortopulmonary window (APW) is rare a congenital heart disease accounting for 0.1%-0.2% of all congenital heart defects. The 35% of the APW has been associated with wide variety of other structural heart diseases such as ventricular septal defect, persistent ductus arteriosus, arch anomalies and coronary artery anomalies. To the best of our knowledge, only six cases of APW with pulmonary atresia with ventricular septal defect has been described in the literature. It resembles the type 1 truncus arteriosus, and differentiation from this condition is important prior to surgical correction...
June 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29892540/black-lungs-and-big-nodes-a-case-of-airway-anthracosis-with-bronchial-anthracofibrosis
#19
S R Devarajan, N Zarrin-Khameh, P Alapat
We present a case of a 76 year-old, non-smoking Honduran female who was referred to our clinic for years of persistent dry cough. Cardiac evaluation was unremarkable. She denied symptoms of heartburn, allergic rhinitis, and there was no personal or family history of asthma. Her physical exam demonstrated wheezing over the right mid-posterior chest. Spirometry was within normal limits. CT-imaging of the chest demonstrated right middle lobe bronchus and lingular segmental bronchus narrowing with bibasilar atelectasis and mild interlobular septal thickening with prominent mediastinal adenopathy...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29892087/a-gene-centric-strategy-for-identifying-disease-causing-rare-variants-in-dilated-cardiomyopathy
#20
Claire Horvat, Renee Johnson, Lien Lam, Jacob Munro, Francesco Mazzarotto, Angharad M Roberts, Daniel S Herman, Michael Parfenov, Alireza Haghighi, Barbara McDonough, Steven R DePalma, Anne M Keogh, Peter S Macdonald, Christopher S Hayward, Amy Roberts, Paul J R Barton, Leanne E Felkin, Eleni Giannoulatou, Stuart A Cook, J G Seidman, Christine E Seidman, Diane Fatkin
PURPOSE: We evaluated strategies for identifying disease-causing variants in genetic testing for dilated cardiomyopathy (DCM). METHODS: Cardiomyopathy gene panel testing was performed in 532 DCM patients and 527 healthy control subjects. Rare variants in 41 genes were stratified using variant-level and gene-level characteristics. RESULTS: A majority of DCM cases and controls carried rare protein-altering cardiomyopathy gene variants. Variant-level characteristics alone had limited discriminative value...
June 11, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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