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Cardiac differentiation

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https://www.readbyqxmd.com/read/29028783/three-dimensional-transesophageal-echocardiography-in-the-guide-of-cardiac-mass-biopsy-future-prospectives
#1
Daniela Di Lisi, Donatella Raspante, Vincenzo Lavanco, Mirko Curzi, Francesca Macaione, Massimo Cavallaro, Riccardo Tona, Giuseppina Novo, Salvatore Novo, Renato M Bragato
: Cardiac tumors are rare. Cardiovascular imaging is more important in the differential diagnosis of cardiac masses but no current noninvasive diagnostic tool has the ability to absolutely diagnose cardiac tumors. In effect cardiac biopsy remains the gold standard in the differential diagnosis. In our case we show the advantages of three-dimensional (3D) transesophageal echocardiography as a guide for cardiac biopsy. We believe that 3D TEE is ready to be used in the guide of cardiac mass biopsy. Once interventionalists become confident with 3D imaging, this technique should be used routinely during these procedures...
October 11, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29026413/evaluation-of-pentraxin-3-level-and-its-related-factors-in-patients-undergoing-primary-percutaneous-coronary-intervention
#2
Saeed Alipour-Parsa, Habib Haybar, Mohammad Hasan Namazi, Morteza Safi, Isa Khaheshi, Mehdi Memaryan, Amir Mohammad Eghbalnejad-Mofrad
BACKGROUND: Inflammation has an important role in the development and progression of atherosclerosis, and acute phase proteins such as pentraxin-3 (PTX3) can be deployed in determining the prognosis of coronary artery disease (CAD). So the purpose of this paper was to evaluate the PTX3 level and its related factors in patients undergoing primary percutaneous coronary intervention (PCI). METHODS: In this cross-sectional study, the PTX3 levels were determined for 100 patients with ST-elevation myocardial infarction referred to the Modarres Hospital, Tehran, Iran...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29026152/genetic-and-epigenetic-profiling-reveals-ezh2-mediated-down-regulation-of-oct-4-involves-nr2f2-during-cardiac-differentiation-of-human-embryonic-stem-cells
#3
Varsha Pursani, Prasad Pethe, Mohsin Bashir, Prabha Sampath, Vivek Tanavde, Deepa Bhartiya
Human embryonic (hES) stem cells are widely used as an in vitro model to understand global genetic and epigenetic changes that occur during early embryonic development. In-house derived hES cells (KIND1) were subjected to directed differentiation into cardiovascular progenitors (D12) and beating cardiomyocytes (D20). Transcriptome profiling of undifferentiated (D0) and differentiated (D12 and 20) cells was undertaken by microarray analysis. ChIP and sequential ChIP were employed to study role of transcription factor NR2F2 during hES cells differentiation...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025425/prognostic-utility-of-differential-tissue-characterization-of-cardiac-neoplasm-and-thrombus-via-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-among-patients-with-advanced-systemic-cancer
#4
Angel T Chan, Andrew J Plodkowski, Shawn C Pun, Yuliya Lakhman, Darragh F Halpenny, Jiwon Kim, Samantha R Goldburg, Mathew J Matasar, Chaya S Moskowitz, Dipti Gupta, Richard Steingart, Jonathan W Weinsaft
BACKGROUND: Late gadolinium enhancement (LGE-) cardiovascular magnetic resonance (CMR) is well-validated for cardiac mass (CMASS) tissue characterization to differentiate neoplasm (CNEO) from thrombus (CTHR): Prognostic implications of CMASS subtypes among systemic cancer patients are unknown. METHODS: CMASS + patients and controls (CMASS -) matched for cancer diagnosis and stage underwent a standardized CMR protocol, including LGE-CMR (IR-GRE) for tissue characterization and balanced steady state free precession cine-CMR (SSFP) for cardiac structure/function...
October 12, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29024690/sodium-channel-current-loss-of-function-in-induced-pluripotent-stem-cell-derived-cardiomyocytes-from-a-brugada-syndrome-patient
#5
Elisabet Selga, Franziska Sendfeld, Rebecca Martinez-Moreno, Claire N Medine, Olga Tura-Ceide, Sir Ian Wilmut, Guillermo J Pérez, Fabiana S Scornik, Ramon Brugada, Nicholas L Mills
Brugada syndrome predisposes to sudden death due to disruption of normal cardiac ion channel function, yet our understanding of the underlying cellular mechanisms is incomplete. Commonly used heterologous expression models lack many characteristics of native cardiomyocytes and, in particular, the individual genetic background of a patient. Patient-specific induced pluripotent stem (iPS) cell-derived cardiomyocytes (iPS-CM) may uncover cellular phenotypical characteristics not observed in heterologous models...
October 9, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29024278/why-do-sglt2-inhibitors-reduce-heart-failure-hospitalization-a-differential-volume-regulation-hypothesis
#6
REVIEW
K Melissa Hallow, Gabriel Helmlinger, Peter J Greasley, John J V McMurray, David W Boulton
The effect of a sodium glucose cotransporter 2 inhibitor (SGLT2i) in reducing heart failure hospitalization in the EMPA-REG OUTCOMES trial has raised the possibility of using these agents to treat established heart failure. We hypothesize that osmotic diuresis induced by SGLT2 inhibition, a distinctly different diuretic mechanism than other diuretic classes, results in greater electrolyte-free water clearance, and ultimately in greater fluid clearance from the interstitial fluid (IF) space than from the circulation, potentially resulting in congestion relief with minimal impact on blood volume, arterial filling, and organ perfusion...
October 12, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29024177/differential-regulation-of-two-flna-transcripts-explains-some-of-the-phenotypic-heterogeneity-in-the-loss-of-function-filaminopathies
#7
Zandra A Jenkins, Alison Macharg, Cheng-Yee Chang, Margriet van Kogelenberg, Tim Morgan, Sophia Frentz, Wenhua Wei, Jacek Pilch, Mark Hannibal, Nicola Foulds, George McGillivray, Richard J Leventer, Sixto García-Miñaúr, Stuart Sugito, Scott Nightingale, David M Markie, Tracy Dudding, Raj P Kapur, Stephen P Robertson
Loss-of-function mutations in the X-linked gene FLNA can lead to abnormal neuronal migration, vascular and cardiac defects and congenital intestinal pseudo-obstruction (CIPO), the latter characterised by anomalous intestinal smooth muscle layering. Survival in male hemizygotes for such mutations is dependent on retention of residual FLNA function but it is unclear why a subgroup of males with mutations in the 5' end of the gene can present with CIPO alone. Here we demonstrate evidence for the presence of two FLNA isoforms differing by 28 residues at the N-terminus initiated at ATG(+1) and ATG(+82) ...
October 12, 2017: Human Mutation
https://www.readbyqxmd.com/read/29022259/formation-of-new-cardiomyocytes-in-exercise
#8
Liang Shen, Hui Wang, Yihua Bei, Dragos Cretoiu, Sanda Maria Cretoiu, Junjie Xiao
Heart failure is a life-threatening disorder associated with the loss of cardiomyocytes. The heart has some endogenous although limited regenerative capacity, thus enhancing cardiac regeneration or stimulating endogenous repair mechanism after cardiac injury is of great interest. The benefits of exercise in heart diseases have been recognized for centuries. Besides the promotion of a favorable cardiac function, exercise is also associated with new cardiomyocytes formation. Exercise may lead to cardiomyocytes renewal from pre-existing cardiomyocytes proliferation or cardiac stem/progenitor cells differentiation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29021611/spatial-detection-of-fetal-marker-genes-expressed-at-low-level-in-adult-human-heart-tissue
#9
Michaela Asp, Fredrik Salmén, Patrik L Ståhl, Sanja Vickovic, Ulrika Felldin, Marie Löfling, José Fernandez Navarro, Jonas Maaskola, Maria J Eriksson, Bengt Persson, Matthias Corbascio, Hans Persson, Cecilia Linde, Joakim Lundeberg
Heart failure is a major health problem linked to poor quality of life and high mortality rates. Hence, novel biomarkers, such as fetal marker genes with low expression levels, could potentially differentiate disease states in order to improve therapy. In many studies on heart failure, cardiac biopsies have been analyzed as uniform pieces of tissue with bulk techniques, but this homogenization approach can mask medically relevant phenotypes occurring only in isolated parts of the tissue. This study examines such spatial variations within and between regions of cardiac biopsies...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021323/pathologic-stimulus-determines-lineage-commitment-of-cardiac-c-kit-cells
#10
Zhongming Chen, Wuqiang Zhu, Ingrid Bender, Wuming Gong, Il-Youp Kwak, Amritha Yellamilli, Thomas J Hodges, Natsumi Nemoto, Jianyi Zhang, Daniel J Garry, Jop H van Berlo
Background -Although cardiac c-kit(+) cells are being tested in clinical trials, the circumstances that determine lineage differentiation of c-kit(+) cells in vivo are unknown. Recent findings suggest endogenous cardiac c-kit(+) cells rarely contribute cardiomyocytes to the adult heart. We assessed whether various pathological stimuli differentially affect the eventual cell fates of c-kit(+) cells. Methods -We employed single cell sequencing and genetic lineage tracing of c-kit(+) cells to determine whether various pathologic stimuli would result in different fates of c-kit(+) cells...
October 11, 2017: Circulation
https://www.readbyqxmd.com/read/29020730/palpitations-when-you-hear-hoof-beats-don-t-forget-to-think-zebras
#11
Ralf E Harskamp, Odile B Thole, Izaäk Moggré
In general practice palpitations are reported in around 8 per 1,000 persons per year. The differential diagnosis includes cardiac and psychiatric causes, as well as numerous others e.g. anaemia, hyperthyroidism, prescribed medication, caffeine and recreational drugs. Factors that point towards a cardiac aetiology are male sex, irregular heartbeat, history of heart disease, event duration > 5 minutes, frequent palpitations, and palpitations which occur at work or disturb sleep. Other clues suggesting a cardiac origin are abrupt onset and termination of palpitations, positional palpitations, and accompanying symptoms such as dizziness and presyncope...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29020403/cardiac-and-systemic-rejuvenation-after-cardiosphere-derived-cell-therapy-in-senescent-rats
#12
Lilian Grigorian-Shamagian, Weixin Liu, Soraya Fereydooni, Ryan C Middleton, Jackelyn Valle, Jae Hyung Cho, Eduardo Marbán
Aim: The aim is to assess the effects of CDCs on heart structure, function, gene expression, and systemic parameters in aged rats. Diastolic dysfunction is characteristic of aged hearts. Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however, the effects of CDCs on aging have not been evaluated. Methods and Results: We compared intra-cardiac injections of neonatal rat CDCs to vehicle (phosphate-buffered saline, PBS) in 21...
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29019149/leukemia-inhibitory-factor-increases-survival-of-pluripotent-stem-cell-derived-cardiomyocytes
#13
Carolina Blugüermann, Leonardo Romorini, Denis Evseenko, Ximena Garate, Gabriel Neiman, Gustavo Emilio Sevlever, María Elida Scassa, Santiago Gabriel Miriuka
Leukemia inhibitory factor (LIF) is a growth factor with pleiotropic biological functions. It has been reported that LIF acts at different stages during mesoderm development. Also, it has been shown that LIF has a cytoprotective effect on neonatal murine cardiomyocytes (CMs) in culture, but little is known about the role of LIF during human cardiogenesis. Thus, we analyzed the effects of LIF on human pluripotent stem cells (PSC) undergoing cardiac differentiation. We first showed that LIF is expressed in the human heart during early development...
October 10, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29018036/ccnd2-overexpression-enhances-the-regenerative-potency-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-remuscularization-of-injured-ventricle
#14
Wuqiang Zhu, Meng Zhao, Saidulu Mattapally, Sifeng Chen, Jianyi Zhang
Rationale: The effectiveness of transplanted, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for treatment of ischemic myocardial injury is limited by the exceptionally low engraftment rate. Objective: To determine whether overexpression of the cell-cycle activator CCND2 in hiPSC-CMs can increase the graft size and improve myocardial recovery in a mouse model of myocardial infarction (MI) by increasing the proliferation of grafted cells. Methods and Results: Human CCND2 was delivered to hiPSCs via lenti-viral mediated gene transfection...
October 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29018034/a-distinct-cellular-basis-for-early-cardiac-arrhythmias-the-cardinal-manifestation-of-arrhythmogenic-cardiomyopathy-and-the-skin-phenotype-of-cardiocutaneous-syndromes
#15
Jennifer Karmouch, Qiong Q Zhou, Christina Y Miyake, Raffaella Lombardi, Kai Kretzschmar, Marie Bannier-Hélaouët, Hans Clevers, Xander H Wehrens, James T Willerson, Ali J Marian
Rationale: Arrhythmogenic cardiomyopathy (ACM) is caused primarily by mutations in genes encoding desmosome proteins. Ventricular arrhythmias are the cardinal and typically early manifestations, whereas myocardial fibroadiposis is the pathological hallmark. Homozygous DSP (desmoplakin) and JUP (plakoglobin) mutations are responsible for a subset of ACM patients that exhibit cardiac arrhythmias and dysfunction, palmo-planter keratosis, and hair abnormalities (cardiocutaneous syndromes). Objective: To determine phenotypic consequences of deletion of Dsp in a subset of cells common to the heart and skin...
October 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29016754/cardiac-troponins-from-myocardial-infarction-to-chronic-disease
#16
Kyung Chan Park, David C Gaze, Paul O Collinson, Michael S Marber
Elucidation of the physiologically distinct subunits of troponin in 1973 greatly facilitated our understanding of cardiac contraction. Although troponins are expressed in both skeletal and cardiac muscle, there are isoforms of troponin I/T expressed selectively in the heart. By exploiting cardiac-restricted epitopes within these proteins, one of the most successful diagnostic tests to-date has been developed: cardiac troponin (cTn) assays. For the past decade, cTn has been regarded as the gold-standard marker for acute myocardial necrosis: the pathological hallmark of acute myocardial infarction (AMI)...
September 14, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29016556/the-current-status-and-future-of-cardiac-stem-progenitor-cell-therapy-for-congenital-heart-defects-from-diabetic-pregnancy
#17
REVIEW
Jianxiang Zhong, Shengbing Wang, Wei-Bin Shen, Sunjay Kaushal, Peixin Yang
Pregestational maternal diabetes induces congenital heart defects (CHDs). Cardiac dysfunction after palliative surgical procedures contributes to the high mortality of CHD patients. Autologous or allogeneic stem cell therapies are effective for improving cardiac function in animal models and clinical trials. c-kit(+) cardiac progenitor cells (CPCs), the most recognized CPCs, have the following basic properties of stem cells: self-renewal, multicellular clone formation, and differentiation into multiple cardiac lineages...
October 10, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28994685/rhabdomyolysis-and-compartment-syndrome-in-a-bodybuilder-undergoing-minimally-invasive-cardiac-surgery
#18
Sebastian John Baxter, Madhusudan Rao Puchakayala, Vinayak N Bapat
Rhabdomyolysis is the result of skeletal muscle tissue injury and is characterized by elevated creatine kinase levels, muscle pain, and myoglobinuria. It is caused by crush injuries, hyperthermia, drugs, toxins, and abnormal metabolic states. This is often difficult to diagnose perioperatively and can result in renal failure and compartment syndrome if not promptly treated. We report a rare case of inadvertent rhabdomyolysis and compartment syndrome in a bodybuilder undergoing minimally invasive cardiac surgery...
October 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28993268/nanotoxicological-and-teratogenic-effects-a-linkage-between-dendrimer-surface-charge-and-zebrafish-developmental-stages
#19
Maria Natalia Calienni, Daniela Agustina Feas, Daniela Edith Igartúa, Nadia Silvia Chiaramoni, Silvia Del Valle Alonso, Maria Jimena Prieto
This article reports novel results about nanotoxicological and teratogenic effects of the PAMAM dendrimers DG4 and DG4.5 in zebrafish (Danio rerio). Zebrafish embryos and larvae were used as a rapid, high-throughput, cost-effective whole-animal model. The objective was to provide a more comprehensive and predictive developmental toxicity screening of DG4 and DG4.5 and test the influence of their surface charge. Nanotoxicological and teratogenic effects were assessed at developmental, morphological, cardiac, neurological and hepatic level...
October 6, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28990258/baseline-connectome-modular-abnormalities-in-the-childhood-phase-of-a-longitudinal-study-on-individuals-with-chromosome-22q11-2-deletion-syndrome
#20
Liang Zhan, Lisanne M Jenkins, Aifeng Zhang, Giorgio Conte, Angus Forbes, Danielle Harvey, Kathleen Angkustsiri, Naomi J Goodrich-Hunsaker, Courtney Durdle, Aaron Lee, Cyndi Schumann, Owen Carmichael, Kristopher Kalish, Alex D Leow, Tony J Simon
Occurring in at least 1 in 3,000 live births, chromosome 22q11.2 deletion syndrome (22q11DS) produces a complex phenotype that includes a constellation of medical complications such as congenital cardiac defects, immune deficiency, velopharyngeal dysfunction, and characteristic facial dysmorphic features. There is also an increased incidence of psychiatric diagnosis, especially intellectual disability and ADHD in childhood, lifelong anxiety, and a strikingly high rate of schizophrenia spectrum disorders, which occur in around 30% of adults with 22q11DS...
October 8, 2017: Human Brain Mapping
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