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https://www.readbyqxmd.com/read/27916291/intratumoral-immunization-by-p19arf-and-interferon-%C3%AE-gene-transfer-in-a-heterotopic-mouse-model-of-lung-carcinoma
#1
João Paulo Portela Catani, Ruan F V Medrano, Aline Hunger, Paulo Del Valle, Sandy Adjemian, Daniela Bertolini Zanatta, Guido Kroemer, Eugenia Costanzi-Strauss, Bryan E Strauss
Therapeutic strategies that act by eliciting and enhancing antitumor immunity have been clinically validated as an effective treatment modality but may benefit from the induction of both cell death and immune activation as primary stimuli. Using our AdRGD-PG adenovector platform, we show here for the first time that in situ gene transfer of p19Arf and interferon-β (IFNβ) in the LLC1 mouse model of lung carcinoma acts as an immunotherapy. Although p19Arf is sufficient to induce cell death, only its pairing with IFNβ significantly induced markers of immunogenic cell death...
December 2016: Translational Oncology
https://www.readbyqxmd.com/read/27900591/treatment-of-lung-tumours-with-high-energy-microwave-ablation-a-single-centre-experience
#2
Anna Maria Ierardi, Andrea Coppola, Natalie Lucchina, Gianpaolo Carrafiello
The purpose of our study is to report safety, technical success, effectiveness, local progression-free survival (LPFS) and overall survival of percutaneous microwave ablation (MWA) to treat lung tumours unsuitable for surgery. Nineteen patients with thirty-one tumours (mean diameter 2.4 cm) underwent percutaneous MWA in 28 sessions. Microwave ablation was carried out using a 2450-MHz generator (Emprint/Covidien, Boulder, CO, USA). Procedures were performed under cone-beam CT (CBCT) and under fluoro-CT (one session) guidance...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27893707/blockade-of-the-il-6-trans-signalling-stat3-axis-suppresses-cachexia-in-kras-induced-lung-adenocarcinoma
#3
A Miller, L McLeod, S Alhayyani, A Szczepny, D N Watkins, W Chen, P Enriori, W Ferlin, S Ruwanpura, B J Jenkins
Lung cancer is the leading cause of cancer death worldwide, and is frequently associated with the devastating paraneoplastic syndrome of cachexia. The potent immunomodulatory cytokine interleukin (IL)-6 has been linked with the development of lung cancer as well as cachexia; however, the mechanisms by which IL-6 promotes muscle wasting in lung cancer cachexia are ill-defined. In this study, we report that the gp130(F/F) knock-in mouse model displaying hyperactivation of the latent transcription factor STAT3 via the common IL-6 cytokine family signalling receptor, gp130, develops cachexia during Kras-driven lung carcinogenesis...
November 28, 2016: Oncogene
https://www.readbyqxmd.com/read/27889091/breath-hold-pet-ct-guided-tumour-ablation-under-general-anaesthesia-accuracy-of-tumour-image-registration-and-projected-ablation-zone-overlap
#4
P B Shyn, S Tremblay-Paquet, K Palmer, S Tatli, K Tuncali, O I Olubiyi, N Hata, S G Silverman
AIM: To assess single-breath-hold combined positron-emission tomography/computed tomography (PET/CT) for accuracy of tumour image registration and projected ablation volume overlap in patients undergoing percutaneous PET/CT-guided tumour-ablation procedures under general anaesthesia. MATERIALS AND METHODS: Eight patients underwent 12 PET/CT-guided tumour-ablation procedures to treat 20 tumours in the lung, liver, or adrenal gland. Using breath-hold PET/CT, the centre of the tumour was marked on each PET and CT acquisition by four readers to assess two- (2D) and three-dimensional (3D) spatial misregistration...
November 23, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27885858/a-systematic-review-of-outcomes-following-stereotactic-ablative-radiotherapy-in-the-treatment-of-early-stage-primary-lung-cancer
#5
Patrick Murray, Kevin Franks, Gerard G Hanna
Stereotactic ablative body radiotherapy (SABR) describes a radiotherapy technique where high doses of radiation are precisely delivered to an extra-cranial target within the body, using either a single fraction of radiotherapy or using multiple small number of fractions. SABR has now become the standard of care treatment for patients with early stage NSCLC for whom surgery is not appropriate. This systematic review considers the evidence supporting the use of SABR in early stage NSCLC, reported toxicity rates, the use of SABR in centrally located NSCLC, the use of SABR as salvage therapy following surgery or radiotherapy and future potential drug combinations with SABR...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27878479/total-transthoracic-approach-facilitates-laparoscopic-hepatic-resection-in-patients-with-significant-prior-abdominal-surgery
#6
Suguru Yamashita, Evelyne Loyer, Hyunseon C Kang, Thomas A Aloia, Yun Shin Chun, Reza J Mehran, Cathy Eng, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: While the oncologic safety of minimally invasive hepatectomy for colorectal liver metastases (CLM) has been demonstrated, lesions in the postero-superior segments may be challenging.1 (-) 3 For these lesions, a transthoracic approach may be particularly helpful, especially in patients with a hostile/reoperative abdomen or morbid obesity.4 (,) 5 PATIENT: A 43-year-old man with a body mass index of 36.0 who had undergone rectosigmoid resection for primary cancer 5 years ago recurred with a solitary liver metastasis in SVIII...
November 22, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27877209/impact-of-systemic-therapy-and-recurrence-pattern-on-survival-outcome-after-radiofrequency-ablation-for-colorectal-liver-metastases
#7
Axel Stang, Marcello Donati, Hauke Weilert, Karl Jürgen Oldhafer
Background: Most patients undergoing radiofrequency ablation (RFA) of colorectal liver metastasases (CLM) develop disease recurrence, but little is known about the effect of recurrence patterns and/or systemic therapy on outcome. In this study, we examined the recurrence patterns and survival after systemic therapy plus RFA in patients with unresectable CLM without extrahepatic disease. The aims were to analyze the effect of recurrence patterns on survival and to assess the relative benefit contributed by systemic therapy and local ablation to disease control and patient outcome...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27875060/open-versus-thoracoscopic-rfa-assisted-lung-resection
#8
Anna Poupalou, Michael Kontos, Evangelos Felekouras, Apostolos Papalois, Nikolaos Kavantzas, George Agrogiannis, Fatima Yagoubi, Periklis Tomos
The purpose of this study was to evaluate Radio Frequency Ablation (RFA)-assisted lung parenchymal transection through thoracotomy and thoracoscopy. Twelve domestic pigs underwent RFA-assisted lingulectomy: six through thoracotomy (group A), and six with thoracoscopy (group B). There was no mortality, no bleeding, or air leak intra- or postoperatively in either of the groups, and no conversion to open thoracotomy in group B. Group A had longer operating period and more pleural adhesions. A barotrauma, a skin burn, and a localized infection were observed in this group...
November 22, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27870704/clinical-outcomes-for-stereotactic-ablative-radiotherapy-in-oligometastatic-and-oligoprogressive-gynecological-malignancies
#9
Shane Mesko, Kiri Sandler, Joshua Cohen, Gottfried Konecny, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: We report single-institution clinical outcomes of women treated with stereotactic ablative radiotherapy (SABR) for oligometastatic or progressive gynecological malignancies. MATERIALS AND METHODS: From 2009 to 2015, 47 lesions from 28 patients were treated with SABR and retrospectively analyzed. All patients had oligometastatic (93%) or oligoprogressive (7%) disease. Primary cancer diagnoses were 15 ovarian, 8 endometrial, 2 cervical, 2 vaginal, and 1 uterine carcinosarcoma...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27870682/advances-in-interventional-oncology-lung-cancer
#10
Philip J Dempsey, Carole A Ridge, Stephen B Solomon
Image-guided lung intervention in the oncologic patient includes transthoracic needle biopsy, thermal ablation, fiducial placement, and tunneled pleural catheter placement and is made possible by technical advancements in computed tomography, fluoroscopy, and ultrasound technology, as well as the proliferation of available thermal ablation modalities such as radiofrequency, microwave, and cryoablation. With increasingly earlier cancer diagnoses being made and a greater patient demand for minimally invasive therapies, interventional oncology has many options to offer the patient with thoracic malignancies...
November 2016: Cancer Journal
https://www.readbyqxmd.com/read/27867576/resection-with-preserved-histologic-morphology-of-a-rare-tumour-via-bronchoscopic-cryosurgery
#11
Jessica Han Ying Tan, Angela Maria Takano, Anne Ann Ling Hsu
Tracheobronchial leiomyoma is a rare pulmonary neoplasm accounting for <2% of benign tumours of the lower airway. Published case series reported bronchoscopic resectability with laser ablation for lesions located in the large airway. Surgery was performed for tumours with wide-based and tumours located in segmental bronchus or lung parenchyma. This is the first reported case of complete bronchoscopic cryoresection of leiomyoma arising from the subsegmental bronchi and illustrating the cryopreservation of its histologic morphology...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27862899/pro-apoptotic-noxa-is-involved-in-ablative-focal-irradiation-induced-lung-injury
#12
Jee-Youn Kim, Yong-Min An, Won Hoon Choi, Jin-Mo Kim, Samju Cho, Byung Rok Yoo, Jeong Wook Kang, Yun-Sil Lee, Yoon-Jin Lee, Jaeho Cho
Although lung injury including fibrosis is a well-documented side effect of lung irradiation, the mechanisms underlying its pathology are poorly understood. X-rays are known to cause apoptosis in the alveolar epithelial cells of irradiated lungs, which results in fibrosis due to the proliferation and differentiation of fibroblasts and the deposition of collagen. Apoptosis and BH3-only pro-apoptotic proteins have been implicated in the pathogenesis of pulmonary fibrosis. Recently, we have established a clinically analogous experimental model that reflects focal high-dose irradiation of the ipsilateral lung...
November 15, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27861515/involvement-of-igf1r-in-bronchiolar-epithelial-regeneration-role-during-repair-kinetics-after-selective-club-cell-ablation
#13
Icíar P López, Sergio Piñeiro-Hermida, Rosete S Pais, Raquel Torrens, Andreas Hoeflich, José G Pichel
Regeneration of lung epithelium is vital for maintaining airway function and integrity. An imbalance between epithelial damage and repair is at the basis of numerous chronic lung diseases such as asthma, COPD, pulmonary fibrosis and lung cancer. IGF (Insulin-like Growth Factors) signaling has been associated with most of these respiratory pathologies, although their mechanisms of action in this tissue remain poorly understood. Expression profiles analyses of IGF system genes performed in mouse lung support their functional implication in pulmonary ontogeny...
2016: PloS One
https://www.readbyqxmd.com/read/27861294/induction-of-major-histocompatibility-complex-mismatched-mouse-lung-allograft-acceptance-with-combined-donor-bone-marrow-lung-transplant-using-a-12-hour-nonmyeloablative-conditioning-regimen
#14
Jeffrey M Dodd-O, Sudipto Ganguly, Ante Vulic, Angela Panoskaltsis-Mortari, John F McDyer, Leo Luznik
BACKGROUND: Despite broad and intense conventional immunosuppression, long-term survival after lung transplantation lags behind that for other solid organ transplants, primarily because of allograft rejection. Therefore, new strategies to promote lung allograft acceptance are urgently needed. The purpose of the present study was to induce allograft tolerance with a protocol compatible with deceased donor organ utilization. METHODS: Using the major histocompatibility complex-mismatched mouse orthotopic lung transplant model, we investigated a conditioning regimen consisting of pretransplant T cell depletion, low-dose total body irradiation and posttransplant (donor) bone marrow, and splenocyte infusion followed by posttransplantation cyclophosphamide...
December 2016: Transplantation
https://www.readbyqxmd.com/read/27837451/percutaneous-image-guided-cryoablation-current-applications-and-results-in-the-oncologic-field
#15
Roberto Luigi Cazzato, Julien Garnon, Nitin Ramamurthy, Guillaume Koch, Georgia Tsoumakidou, Jean Caudrelier, Francesco Arrigoni, Luigi Zugaro, Antonio Barile, Carlo Masciocchi, Afshin Gangi
Percutaneous imaging-guided cryoablation (PICA) is a recently developed technique, which applies extreme hypothermia to destroy tumours under close imaging surveillance. It is minimally invasive, safe, repeatable, and does not interrupt or compromise other oncologic therapies. It presents several advantages over more established heat-based thermal ablation techniques (e.g. radiofrequency ablation; RFA) including intrinsic analgesic properties, superior monitoring capability on multi-modal imaging, ability to treat larger tumours, and preservation of tissue collagenous architecture...
December 2016: Medical Oncology
https://www.readbyqxmd.com/read/27833402/short-term-outcomes-and-safety-of-computed-tomography-guided-percutaneous-microwave-ablation-of-solitary-adrenal-metastasis-from-lung-cancer-a-multi-center-retrospective-study
#16
Min Men, Xin Ye, Weijun Fan, Kaixian Zhang, Jingwang Bi, Xia Yang, Aimin Zheng, Guanghui Huang, Zhigang Wei
OBJECTIVE: To retrospectively evaluate the short-term outcomes and safety of computed tomography (CT)-guided percutaneous microwave ablation (MWA) of solitary adrenal metastasis from lung cancer. MATERIALS AND METHODS: From May 2010 to April 2014, 31 patients with unilateral adrenal metastasis from lung cancer who were treated with CT-guided percutaneous MWA were enrolled. This study was conducted with approval from local Institutional Review Board. Clinical outcomes and complications of MWA were assessed...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27826789/avoiding-complications-in-bone-and-soft-tissue-ablation
#17
A Nicholas Kurup, Grant D Schmit, Jonathan M Morris, Thomas D Atwell, John J Schmitz, Adam J Weisbrod, David A Woodrum, Patrick W Eiken, Matthew R Callstrom
As with percutaneous ablation of tumors in the liver, lungs, and kidneys, ablation of bone and non-visceral soft tissue tumors carries risk, primarily from collateral damage to vital structures in proximity to the target tumor. Certain risks are of particular interest when ablating bone and non-visceral soft tissue tumors, namely neural or skin injury, bowel injury, fracture, and gas embolism from damaged applicators. Ablation of large volume tumors also carries special risk. Many techniques may be employed by the interventional radiologist to minimize complications when treating tumors in the musculoskeletal system...
November 8, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27826243/genetic-ablation-of-cxcr2-protects-against-cigarette-smoke-induced-lung-inflammation-and-injury
#18
Chad A Lerner, Wei Lei, Isaac K Sundar, Irfan Rahman
Antagonism of CXCR2 receptors, predominately located on neutrophils and critical for their immunomodulatory activity, is an attractive pharmacological therapeutic approach aimed at reducing the potentially damaging effects of heightened neutrophil influx into the lung. The role CXCR2 in lung inflammation in response to cigarette smoke (CS) inhalation using the mutant mouse approach is not known. We hypothesized that genetic ablation of CXCR2 would protect mice against CS-induced inflammation and DNA damage response...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27824668/computed-tomography-guided-tumor-ablation-analysis-and-optimization-of-computed-tomography-technique-with-various-ablation-devices
#19
Adam E M Eltorai, Grayson L Baird, Nicholas Monu, Darren Bialo, Scott Collins, Jeom Soon Kim, Damian E Dupuy
PURPOSE: Ablation device-associated computed tomography beam hardening artifacts can make tumor margin visualization and its relationship to the ablation applicator tip challenging. Determine optimal scanning conditions for currently-used applicators. MATERIALS AND METHODS: Eleven applicators were placed in ex vivo cow livers with implanted mock tumors, surrounded by bolus gel. Various computed tomography scans were performed at 440 mA with 5 mm thickness changing kVp (80, 100, 120, 140), scan time (0...
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27815575/the-role-of-interventional-oncology-in-the-management-of-lung-cancer
#20
Ejona Duka, Anna Maria Ierardi, Chiara Floridi, Alberto Terrana, Federico Fontana, Gianpaolo Carrafiello
Interventional radiological procedures for diagnosis and treatment of lung cancer have become increasingly important. Imaging-guided percutaneous biopsy has become the modality of choice for diagnosing lung cancer, and in the era of target therapies, it is an useful tool to define earlier patient-specific tumor phenotypes. In functionally inoperable patients, especially the ablative procedures are potentially curative alternatives to surgery. In addition to thermally ablative treatment, selective chemoembolization by a vascular access allows localized therapy...
November 4, 2016: Cardiovascular and Interventional Radiology
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