keyword
MENU ▼
Read by QxMD icon Read
search

lung ablation

keyword
https://www.readbyqxmd.com/read/29771774/bronchoscopic-laser-interstitial-thermal-therapy-an-experimental-study-in-normal-porcine-lung-parenchyma
#1
Roberto F Casal, Garrett Walsh, Mark McArthur, Lori R Hill, Maria F Landaeta, Aristides J Armas Villalba, Philip Ong, Labib Debiane, Erik Vakil, Horiana B Grosu, Carlos A Jimenez, David Ost, Roberto Adachi, George A Eapen
BACKGROUND: Population aging and lung cancer screening strategies may lead to an increase in detection of early-stage lung cancer in medical inoperable patients. Recent advances in peripheral bronchoscopy have made it a suitable platform for ablation of small peripheral tumors. METHODS: We investigated the tissue-ablative effect of a diode laser bronchoscopically applied by a laser delivery fiber (LDF) with wide aperture on porcine lung parenchyma. Laser was tested ex vivo and in vivo to identify the most effective power settings and LDF...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29766240/pulmonary-thermal-ablation-enables-long-chemotherapy-free-survival-in-metastatic-colorectal-cancer-patients
#2
Mariane Fonck, Jean-Thomas Perez, Vittorio Catena, Yves Becouarn, Laurent Cany, Eric Brudieux, Laure Vayre, Patrick Texereau, Valérie Le Brun-Ly, Véronique Verger, Véronique Brouste, Dominique Bechade, Xavier Buy, Jean Palussière
BACKGROUND: Chemotherapy (ct) is the preferred treatment option in metastatic colorectal cancer (mCRC). The objective of the study was to determine the overall survival (OS), disease-free survival (DFS) and ct-free survival (CFS) of pulmonary thermal ablation (TA) and its place in the treatment of mCRC. PATIENTS AND METHODS: All consecutive patients treated (over 11 years) with percutaneous TA for lung metastasis of colorectal origin were reviewed. All sequences of treatments were considered...
May 15, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29764837/il22-promotes-kras-mutant-lung-cancer-by-induction-of-a-pro-tumor-immune-response-and-protection-of-stemness-properties
#3
Nasim Khosravi, Mauricio S Caetano, Amber M Cumpian, Nese Unver, Cynthia De la Garza Ramos, Oscar Noble, Soudabeh Daliri, Belinda J Hernandez, Berenice A Gutierrez, Scott E Evans, Samir Hanash, Andrei M Alekseev, Yi Yang, Seon Hee Chang, Roza Nurieva, Humam Kadara, Jichao Chen, Edwin J Ostrin, Seyed Javad Moghaddam
Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are associated with poor prognosis. Using a Kras-induced lung cancer mouse model, CC-LR, we previously showed a role for inflammation in lung tumorigenesis through activation of the NF-kB pathway, along with induction of interleukin 6 (IL6) and an IL17-producing CD4+ T-helper cell response. IL22 is an effector molecule secreted by CD4+ and γδ T cells that we previously found to be expressed in CC-LR mice. IL22 mostly signals through the STAT3 pathway and is thought to act exclusively on non-hematopoietic cells with basal IL22 receptor (IL22R) expression on epithelial cells...
May 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29759428/atrial-fibrillation-and-pulmonary-venous-electrical-conduction-recovery-after-full-surgical-resection-and-anastomosis-of-the-pulmonary-veins-insights-from-follow-up-and-ablation-procedures-in-lung-transplant-recipients
#4
Ayman A Hussein, Tanmay S Panchabhai, Marie M Budev, Khaldoun Tarakji, Amr F Barakat, Walid Saliba, Bruce Lindsay, Oussama M Wazni
OBJECTIVES: The authors report their experience with atrial fibrillation (AF) rates and ablation findings in lung transplant recipients. BACKGROUND: Pulmonary venous (PV) conduction recovery accounts for most failed atrial fibrillation (AF) catheter ablation procedures. Lung transplantation involves full surgical resection and replacement of the recipient's PVs with donor's PVs, which may represent the ultimate PV ablation. METHODS: They followed 755 consecutive lung transplant recipients categorized based on transplant status (unilateral vs...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759331/prognostic-value-of-pretreatment-fdg-pet-parameters-in-high-dose-image-guided-radiotherapy-for-oligometastatic-non-small-cell-lung-cancer
#5
Alexander L Chin, Kiran A Kumar, Haiwei H Guo, Peter G Maxim, Heather Wakelee, Joel W Neal, Maximillian Diehn, Billy W Loo, Michael F Gensheimer
BACKGROUND: Emerging data support aggressive local treatment of oligometastatic non-small-cell lung cancer (NSCLC) patients. We sought to determine whether the metabolic burden of disease found by fluorodeoxyglucose positron emission tomography at the time of high-dose radiotherapy (RT) for oligometastatic NSCLC can serve as a prognostic biomarker. MATERIALS AND METHODS: We conducted a retrospective cohort study of 67 RT treatment courses in 55 patients with oligometastatic NSCLC who had undergone high-dose RT to all sites of active disease at our institution...
April 19, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29754789/it-is-not-just-about-surgery-versus-stereotactic-ablative-radiotherapy-it-is-about-curing-as-many-patients-with-lung-cancer-as-possible
#6
EDITORIAL
Alessandro Brunelli
No abstract text is available yet for this article.
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29742518/immune-checkpoint-inhibitors-in-the-treatment-of-patients-with-neuroendocrine-neoplasia
#7
Matthias M Weber, Christian Fottner
BACKGROUND: Well-differentiated neuroendocrine neoplasms (NENs) are usually controlled by antiproliferative, local ablative and/or radionuclide therapies, whereas poorly differentiated NENs generally require cytotoxic chemotherapy. However, treatment options for patients with advanced/metastatic high-grade NENs remain limited. METHOD: Review of the literature and international congress abstracts on the efficacy and safety of immunotherapy by checkpoint inhibition in advanced/metastatic NENs...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29737958/increased-efficacy-of-stereotactic-ablative-radiation-therapy-after-bevacizumab-in-lung-oligometastases-from-colon-cancer
#8
Rosario Mazzola, Umberto Tebano, Dario Aiello, Gioacchino Di Paola, Niccolò Giaj-Levra, Francesco Ricchetti, Sergio Fersino, Alba Fiorentino, Ruggero Ruggieri, Filippo Alongi
Aim Metastases from colorectal cancer are poorly responsive to stereotactic ablative radiation therapy (SABR) due to intratumoral hypoxia. Intratumoral oxygenation is improved by administration of angiogenesis inhibitors. Thus, there could be a clinical synergistic effect of SABR with bevacizumab on metastases from colorectal cancer. The aim of this study was to evaluate the feasibility and efficacy of SABR after bevacizumab in lung oligometastases from colon cancer. Methods The data of patients with lung metastases from colon cancer who underwent SABR were retrospectively evaluated according to the following inclusion criteria: number of metastases ≤3; lung oligometastases from colon cancer in patients who underwent SABR; patients receiving previous chemotherapy alone or in combination with bevacizumab; Karnofsky performance status >80; life expectancy >6 months; at least 6 months' follow-up after SABR; presence of KRAS mutation...
December 1, 2017: Tumori
https://www.readbyqxmd.com/read/29732193/photodynamic-therapeutic-ablation-for-peripheral-pulmonary-malignancy-via-electromagnetic-navigation-bronchoscopy-localization-in-a-hybrid-operating-room-or-a-pioneering-study
#9
Ke-Cheng Chen, Jang-Ming Lee
Background: With the aid of electromagnetic navigation bronchoscopy (ENB), it has become possible to approach peripheral lung tumors from the airway. Meanwhile, local ablation using photodynamic therapy (PDT) has shown increasing promise in the realm of lung cancer treatment. The purpose of this study was to explore an alternative ablation method using PDT with SuperDimension ENB localization in a hybrid operating theater. Methods: Our study includes patients with primary or metastatic lung cancer who underwent PDT via ENB in the hybrid operating room (OR) of National Taiwan University Hospital between January 2016 and January 2017...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29731224/farrerol-overcomes-the-invasiveness-of-lung-squamous-cell-carcinoma-cells-by-regulating-the-expression-of-inducers-of-epithelial-mesenchymal-transition
#10
Bin Li, Peng Chen, Jie-Hua Wang, Li Li, Jin-Lan Gong, Hui Yao
In recent years Epithelial Mesenchymal Transition (EMT) has been proposed as a mechanism indispensable to acquisition of metastatic properties by tumor cells. In this study we tested the ability of Farrerol, a Chinese herb-derived compound to ablate the EMT in human lung squamous cell carcinoma cells. Human lung squamous cell carcinoma cells, Calu-1 were treated with various concentrations of Farrerol for 24 h to examine its effect on their viability by the MTT assay. Only those concentrations which showed least effect on the viability of Calu-1 cells were further used to evaluate the expression of epithelial and mesenchymal markers by western blotting...
May 4, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29722542/repolarization-of-tumor-associated-macrophages-in-a-genetically-engineered-non-small-cell-lung-cancer-model-by-intraperitoneal-administration-of-hyaluronic-acid-based-nanoparticles-encapsulating-microrna-125b
#11
Neha N Parayath, Avani Parikh, Mansoor M Amiji
Tumor-associated macrophages (TAMs) acquire a pro-tumor (M2) phenotype, which promotes tumor growth, angiogenesis, and metastasis. Certain microRNAs (miRs), such as miR-125b, can reprogram TAMs into an anti-tumor/pro-inflammatory (M1) phenotype. Using CD44 targeting hyaluronic acid-poly(ethyleneimine) (HA-PEI)-based nanoparticles encapsulating miR-125b, we have herein shown macrophage-specific delivery and transfection upon intraperitoneal (i.p.) administration. We have exploited the inherent ability of peritoneal macrophages to migrate towards the inflammation/injury and demonstrated that following intraperitoneal administration of HA-PEI nanoparticles, there is an accumulation of HA-PEI nanoparticles in the macrophage-ablated lung tissues of both naïve and KRAS/p53 double mutant genetically engineered (KP-GEM) non-small cell lung cancer (NSCLC) mouse model...
May 3, 2018: Nano Letters
https://www.readbyqxmd.com/read/29719997/fluorodeoxyglucose-positron-emission-tomography-for-detection-of-tumor-recurrence-following-radiofrequency-ablation-in-retrospective-cohort-of-stage-i-lung-cancer
#12
Yingbing Wang, Michael Lanuti, Adam Bernheim, Jo-Anne O Shepard, Amita Sharma
PURPOSE: The goal of this study was to define patterns for tumor recurrence on PET following RFA, compare time to imaging recurrence by PET versus CT, evaluate whether pre-treatment tumor uptake predicts recurrence and propose an optimal post-RFA surveillance strategy. MATERIALS AND METHODS: A retrospective cohort study was performed of biopsy confirmed primary stage I lung cancers treated with RFA. FDG PET and near contemporaneous diagnostic CT imaging pre-ablation, within 30 days post-ablation, and beyond 6 months were independently and retrospectively evaluated for features supportive of recurrence...
May 3, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29702487/percutaneous-radiofrequency-ablation-of-pulmonary-metastasis-and-thoracic-paravertebral-block-under-computed-tomographic-scan-guidance-a-case-report
#13
Laura Ruscio, Olivier Planche, Paul Zetlaoui, Dan Benhamou
Pain during and after pulmonary percutaneous radiofrequency ablation (RFA) may be severe enough to require opioids. Thoracic paravertebral block (TPVB) is a regional anesthetic technique that can relieve pain during and after abdominal or thoracic painful procedures. We report the use of TPVB to relieve postprocedural pain in a 50-year-old woman after RFA of lung metastasis. The TPVB was performed under computed tomographic guidance by the anesthesiologist. The patient was pain free (rest and mobilization) during the first postoperative 36 hours...
April 26, 2018: A&A practice
https://www.readbyqxmd.com/read/29701371/surgical-treatment-of-complications-55-years-after-extraperiosteal-lucite-ball-plombage-for-pulmonary-tuberculosis
#14
Telma Calado, Magda Alvoeiro, Daniel Cabral, Mariana Antunes, Francisco Félix
INTRODUCTION: In the 1930-50s, before the introduction of antimicrobial drugs and development of techniques of pulmonary resssection, collapse therapy was the mainstream of treatment for cavitary pulmonary tuberculosis. The methods to achieve the collapse included artificial pneumothorax with air refills, phrenic nerve crush, thoracoplasty and extrapleural plombage. The plombage involves creating a cavity surgically under the ribs in the upper chest wall and filling the space with inert material, such fat, paraffin wax, rubber ballons, oil and methyl-methacrylate (Lucite) balls...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700057/how-accurate-is-inverse-electrocardiographic-mapping-a-systematic-in-vivo-evaluation
#15
Laura R Bear, Ian J LeGrice, Gregory B Sands, Nigel A Lever, Denis S Loiselle, David J Paterson, Leo K Cheng, Bruce H Smaill
BACKGROUND: Inverse electrocardiographic mapping reconstructs cardiac electrical activity from recorded body surface potentials. This noninvasive technique has been used to identify potential ablation targets. Despite this, there has been little systematic evaluation of its reliability. METHODS: Torso and ventricular epicardial potentials were recorded simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, epicardial, and endocardial ventricular pacing (70 records in total)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29699605/chitinase-3-like-1-a-novel-regulator-of-th1-ctl-responses-as-a-therapeutic-target-for-increasing-anti-tumor-immunity
#16
Do-Hyun Kim, Je-Min Choi
Chitinase-Like Proteins (CLPs) are an evolutionarily conserved protein which lose their enzymatic activity for degrading chitin macromolecules. Chitinase-3-like-1 (Chi3l1) is a type of CLP that is highly expressed in epithelial cells, macrophages, etc., and is known to have correlations with type 2 inflammation and cancer. Although the increased level of Chi3l1 in the blood was reported in various disease patients, the function of Chi3l1 in adaptive immunity has been totally unknown. Recently, we found that Chi3l1 is expressed in T cells and has a negative regulatory role in T-cell activation and proliferation...
April 27, 2018: BMB Reports
https://www.readbyqxmd.com/read/29690935/combination-therapy-involving-radiofrequency-ablation-and-targeted-chemotherapy-with-bevacizumab-plus-paclitaxel-and-cisplatin-in-a-rabbit-vx2-lung-tumor-model
#17
Ai Ueki, Tomohisa Okuma, Shinichi Hamamoto, Ken Kageyama, Kazuki Murai, Yukio Miki
OBJECTIVE: Radiofrequency ablation (RFA) is less effective for large tumors > 3 cm in diameter. Various studies of combination therapy using RFA and other treatments have been conducted to improve the results of RFA treatment of lung tumors, survival was extended in a tumor model when RFA was followed by concomitant use of systemic chemotherapy. Bevacizumab (BCM) is a one of molecular target drugs. Numerous clinical trials and reports have shown BCM's effect when used in combination with cisplatin (CDDP) in lung tumor...
April 24, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29690905/resolution-of-bleomycin-induced-murine-pulmonary-fibrosis-via-a-splenic-lymphocyte-subpopulation
#18
Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Jiro Usuki, Minoru Inomata, Akemi Morinaga, Takeru Kashiwada, Nobuhiko Nishijima, Shioto Itakura, Nariaki Kokuho, Kenichiro Atsumi, Hiroki Hayashi, Tomoyoshi Yamaguchi, Kazue Fujita, Yoshinobu Saito, Shinji Abe, Kaoru Kubota, Akihiko Gemma
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality, and the pathogenesis of the disease is still incompletely understood. Although lymphocytes, especially CD4+ CD25+ FoxP3+ regulatory T cells (Tregs), have been implicated in the development of IPF, contradictory results have been reported regarding the contribution of Tregs to fibrosis both in animals and humans. The aim of this study was to investigate whether a specific T cell subset has therapeutic potential in inhibiting bleomycin (BLM)-induced murine pulmonary fibrosis...
April 24, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29672204/thoracic-intervention-and-surgery-to-cure-lung-an-overview-of-stereotactic-ablative-radiotherapy-in-early-and-oligometastatic-lung-cancer
#19
Bsh Chia, D Landau, G Hanna, J Conibear
No abstract text is available yet for this article.
January 1, 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29671604/neuropilin-2-regulates-airway-inflammatory-responses-to-inhaled-lipopolysaccharide
#20
Robert M Immormino, David C Lauzier, Hideki Nakano, Michelle L Hernandez, Neil E Alexis, Andrew L Ghio, Stephen L Tilley, Claire M Doerschuk, David B Peden, Donald N Cook, Timothy P Moran
Neuropilins are multifunctional receptors that play important roles in immune regulation. Neuropilin-2 (NRP2) is expressed in the lungs, but whether it regulates airway immune responses is unknown. Here, we report that Nrp2 is weakly expressed by alveolar macrophages (AM) in the steady-state, but is dramatically up-regulated following in vivo lipopolysaccharide (LPS) inhalation. Ex vivo treatment of human AM with LPS also increased NRP2 mRNA expression and cell-surface display of NRP2 protein. LPS-induced Nrp2 expression in AM was dependent upon the MyD88 signaling pathway and the transcription factor nuclear factor kappa B (NFκB)...
April 19, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
keyword
keyword
14367
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"