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Scheuermann's disease

Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
Yun Zhang, Brian D Aevermann, Tavis K Anderson, David F Burke, Gwenaelle Dauphin, Zhiping Gu, Sherry He, Sanjeev Kumar, Christopher N Larsen, Alexandra J Lee, Xiaomei Li, Catherine Macken, Colin Mahaffey, Brett E Pickett, Brian Reardon, Thomas Smith, Lucy Stewart, Christian Suloway, Guangyu Sun, Lei Tong, Amy L Vincent, Bryan Walters, Sam Zaremba, Hongtao Zhao, Liwei Zhou, Christian Zmasek, Edward B Klem, Richard H Scheuermann
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support...
September 26, 2016: Nucleic Acids Research
Martina Roos, Ugo Pradère, Richard P Ngondo, Alok Behera, Sara Allegrini, Gianluca Civenni, Julian A Zagalak, Jean-Rémy Marchand, Mirjam Menzi, Harry Towbin, Jörg Scheuermann, Dario Neri, Amedeo Caflisch, Carlo V Catapano, Constance Ciaudo, Jonathan Hall
New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor suppressor is blocked by an RNA binding protein (RBP) Lin28, which docks onto a conserved sequence in let-7 precursor RNA molecules and prevents their maturation. Thus, the Lin28/let-7 interaction might be an attractive drug target, if not for the well-known difficulty in targeting RNA-protein interactions with drugs. Here, we describe a protein/RNA FRET assay using a GFP-Lin28 donor and a black-hole quencher (BHQ)-labeled let-7 acceptor, a fluorescent protein/quencher combination which is rarely used in screening despite favorable spectral properties...
October 21, 2016: ACS Chemical Biology
Cao Yun, Cai Liang Shen
PURPOSE: Anterior release for Scheuermann's disease was considered an important technique for decades. However, posterior-only surgery for Scheuermann's disease has shown a promising potential to manage this deformity, as well. Correction loss could happen post-operatively, especially when posterior-only surgery is performed in the early days. Therefore, a dispute regarding anterior release for Scheuermann's disease exists. METHODS: We performed a systematic review of studies, reporting the outcomes of anterior release and posterior fusion surgery (AP group) or posterior-only surgery (PO group) for Scheuermann's disease...
July 6, 2016: European Spine Journal
A A Gusarov, V A Fetisov, T A Kuprina
This paper is designed to present an example from the domestic expert practice with the successful application of the radionuclide technique to visualize the bone lesions in a victim of a traffic accident having concomitant pathology of the osseous-articular apparatus (Scheuermann-Mau disease). The use of the osteoscintigraphic method made it possible not only to confirm the injury to the spinal column and the sternum but also to ensure its differential diagnostics from the concurrent pathology. Also, the method allowed to detect the exact location of the fractures...
March 2016: Sudebno-meditsinskaia Ekspertiza
Klaus Konrad Scheuermann, Yulin Jia
The Pi9 gene in rice, originating from Oryza minuta, is an effective resistance gene for controlling rice blast disease. However, currently available linked DNA markers do not accurately identify the function of Pi9, thus hindering its efficient incorporation into new cultivars through marker-assisted selection (MAS). In addition, no known Pi9-containing rice germplasm is available to breeders. In the present study, DNA sequence variation of Pi9 alleles and their family members was analyzed in 40 diverse rice germplasm accessions from the AA genome to develop a robust Pi9 marker...
August 2016: Phytopathology
M Moustarhfir, B Bresson, P Koch, A Perozziello, G Barreau, E Schouman-Claeys, M-C Henry-Feugeas, P Ou, B Dallaudière
PURPOSE: The purpose of our prospective study was to assess the presentation of Schmorl's nodes (SN) on magnetic resonance imaging (MRI) and investigate their possible association with demographic and clinical findings. MATERIALS AND METHODS: Three hundred and thirty-three patients were prospectively included. Thirteen (3.9%) patients were excluded because of contraindication to MRI and/or Scheuermann's disease. The final study population included 320 patients. T1-weighted and short TI inversion recovery sequences were performed to assess SN prevalence, the vertebral level and their anatomical distribution in vertebra...
April 2016: Diagnostic and Interventional Imaging
Smadar Peleg, Gali Dar, Nili Steinberg, Youssef Masharawi, Israel Hershkovitz
To examine whether the association between spinal alignment and sacral anatomical orientation (SAO) can be detected in skeletal populations, by comparing SAO values in individuals with a typical SD to individuals with normal spinal alignment. 2025 skeletons were screened for Scheuermann's disease. Scheuermann's kyphosis was established by the presence of apophyseal abnormalities associated with more than 5° of anterior wedging in each of three adjacent vertebrae. SAO was measured as the angle created between the intersection of a line running parallel to the superior surface of the sacrum and a line running between the anterior superior iliac spine and the anterior-superior edge of the symphysis pubis (PUBIS)...
2016: SpringerPlus
Jessica Becker, Stefan Niebisch, Arcangelo Ricchiuto, Eva J Schaich, Gavin Lehmann, Tobias Waltgenbach, Annette Schafft, Timo Hess, Frank Lenze, Marino Venerito, Robert Hüneburg, Philipp Lingohr, Hanno Matthaei, Stefan Seewald, Uwe Scheuermann, Nicole Kreuser, Lothar Veits, Mira M Wouters, Henning R Gockel, Hauke Lang, Michael Vieth, Michaela Müller, Alexander J Eckardt, Burkhard H A von Rahden, Michael Knapp, Guy E Boeckxstaens, Rolf Fimmers, Markus M Nöthen, Henning G Schulz, Ines Gockel, Johannes Schumacher
BACKGROUND AND AIM: Although an eight-residue insertion in HLA-DQβ1 has been recently identified as a genetic risk factor for idiopathic achalasia, other risk factors are still unknown. In the present study, we carried out an epidemiological survey and a genotype-phenotype (G×P) analysis to gain further insights into the etiology of achalasia. METHODS: We obtained medical data from 696 achalasia patients and 410 controls, as well as their first-degree relatives (2543 of patients and 1497 of controls)...
June 2016: European Journal of Gastroenterology & Hepatology
Melvin Mohokum, Samuel Schülein, Adrian Skwara
To investigate and monitor the progression of scoliosis and other spinal deformities in patients following idiopathic scoliosis (IS), non-invasive and radiation-free techniques are recommended because of the need for repeated radiographs. In a clinical setting, spine parameters can be quickly, cheaply and easily assessed using rasterstereography (RS). To assess the validity of the radiation-free technique RS based on surface topography compared with radiographs. MEDLINE, the Cochrane Library and EMBASE were systematically searched for studies which investigate the validity of rasterstereography compared with x-ray measurements...
September 28, 2015: Orthopedic Reviews
Piotr Janusz, Marcin Tyrakowski, Tomasz Kotwicki, Kris Siemionow
STUDY DESIGN: Retrospective evaluation of radiographs. OBJECTIVE: The aim of this study was to assess sagittal cervical balance in patients with the two types Scheuermann disease (SD). SUMMARY OF BACKGROUND DATA: The structural hyperkyphosis characterizing SD may be localized in the thoracic (SDT) or thoraco-lumbar (SDTL) spine segments. This may affect sagittal cervical balance. METHODS: Seventy-one patients (41 males and 30 females), aged 16...
December 2015: Spine
K Holzapfel, E C Schubert, S Huber-Wagner, J Neu
A 59-year-old patient with right-sided chest pains after a fall from a height of 3 m was referred to hospital by an emergency physician. The chest x-rays showed fractures of the third and seventh ribs on the right side. Inpatient analgesic therapy was initiated and after 3 days the patient was discharged from hospital for further outpatient treatment. As the pain persisted the patient consulted a surgeon 5 weeks later and the first X-ray examination of the spine was carried out which revealed the formation of several wedge-shaped thoracolumbar vertebral bodies...
February 2016: Der Unfallchirurg
J M Gennari, C Themar-Noel, M Panuel, B Bensamoun, C Deslandre, A Linglart, M Sokolowski, A Ferrari
INTRODUCTION: Ten to twenty percent of persons experience spinal pain during growth. Causes are diverse in adolescents, and it is essential to determine etiology rapidly so as to guide optimal management. HYPOTHESIS: It is important for the pediatric orthopedist to understand the natural history of conditions inducing spinal pain. MATERIAL AND METHODS: A retrospective study included 116 adolescents presenting with spinal pain at the Hôpital Nord (Marseille, France) between January 1, 2009 and January 1, 2014...
October 2015: Orthopaedics & Traumatology, Surgery & Research: OTSR
Chiaowen Hsiao, Mengya Liu, Rick Stanton, Monnie McGee, Yu Qian, Richard H Scheuermann
Flow cytometry (FCM) is a fluorescence-based single-cell experimental technology that is routinely applied in biomedical research for identifying cellular biomarkers of normal physiological responses and abnormal disease states. While many computational methods have been developed that focus on identifying cell populations in individual FCM samples, very few have addressed how the identified cell populations can be matched across samples for comparative analysis. This article presents FlowMap-FR, a novel method for cell population mapping across FCM samples...
January 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
J Moritz Kaths, Daniel B Foltys, Uwe Scheuermann, Mari Strempel, Stefan Niebisch, Maren Ebert, Boris Jansen-Winkeln, Ines Gockel, Hauke Lang
INTRODUCTION: Achalasia is one of the most common causes of dysphagia. Typical symptoms include difficulties in controlling the swallowing process, regurgitation, weight loss, and chest pain. A megaesophagus rarely causes tracheal compression with consecutive acute dyspnea or similar respiratory symptoms. PRESENTATION OF CASE: A 23-year-old male patient presented with difficulties in swallowing, a consecutive massive weight loss over the past three years, and minor respiratory ailments...
2015: International Journal of Surgery Case Reports
Severine Hurni, Daniela Scheuermann, Simon G Krattinger, Bettina Kessel, Thomas Wicker, Gerhard Herren, Mirjam N Fitze, James Breen, Thomas Presterl, Milena Ouzunova, Beat Keller
Northern corn leaf blight (NCLB) caused by the hemibiotrophic fungus Exserohilum turcicum is an important foliar disease of maize that is mainly controlled by growing resistant maize cultivars. The Htn1 locus confers quantitative and partial NCLB resistance by delaying the onset of lesion formation. Htn1 represents an important source of genetic resistance that was originally introduced from a Mexican landrace into modern maize breeding lines in the 1970s. Using a high-resolution map-based cloning approach, we delimited Htn1 to a 131...
July 14, 2015: Proceedings of the National Academy of Sciences of the United States of America
Matthew L Webb, Adam M Lukasiewicz, Andre M Samuel, Daniel D Bohl, Bryce A Basques, Arya G Varthi, Jonathan N Grauer
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To compare the infection rates in the Scoliosis Research Society (SRS) morbidity and mortality database to those in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. SUMMARY OF BACKGROUND DATA: Surgical databases have demonstrated value in orthopaedic surgery. However, few studies in the literature have used the SRS database relative to other available databases...
September 15, 2015: Spine
G Armbrecht, D Felsenberg, M Ganswindt, M Lunt, S K Kaptoge, K Abendroth, A Aroso, D Banzer, A K Bhalla, J Dequeker, R Eastell, K Hoszowski, G Lyritis, P D Delmas, P Masaryk, T Miazgowski, J Cannata, R Nuti, L Oei, G Poor, I Redlund-Johnell, D M Reid, W Reisinger, H Schatz, C J Todd, A D Woolf, K Javaid, F Rivadeneira, A J Silman, C Cooper, T W O'Neill, J Reeve
UNLABELLED: In 27 centres across Europe, the prevalence of deforming spinal Scheuermann's disease in age-stratified population-based samples of over 10,000 men and women aged 50+ averaged 8% in each sex, but was highly variable between centres. Low DXA BMD was un-associated with Scheuermann's, helping the differential diagnosis from osteoporosis. INTRODUCTION: This study aims to assess the prevalence of Scheuermann's disease of the spine across Europe in men and women over 50 years of age, to quantitate its association with bone mineral density (BMD) and to assess its role as a confounder for the radiographic diagnosis of osteoporotic fracture...
October 2015: Osteoporosis International
J Hurtado-Avilés, J Roca-González, F Santonja-Medina
Schëuermanńs kyphosis is usually observed with a mild idiopathic scoliosis, and there is parity between these two diseases. The aim of this work is to establish a hypothesis about the existence of a biomechanical causal relationship between Schëuermann's kyphosis and scoliosis. To achieve this, a literature review was conducted. A simple mechanical model of the passive thoracolumbar subsystem was created to support part of the discussion. This mechanical model describes the passive thoracolumbar subsystem under ideal conditions of equilibrium...
July 2015: Medical Hypotheses
Tomer Bezalel, Leonid Kalichman
BACKGROUND: Scheuermann's disease is the most common cause of hyperkyphosis of the thoracolumbar spine. Few case reports have demonstrated the effectiveness of Schroth therapy in improving the thoracic angle curve in Scheuermann's patients; however, additional verification is needed. CASE DESCRIPTION: A 14-year-old female patient presented with Scheuermann's disease. On X-ray, thoracic kyphosis was 55° and lumbar lordosis 55°. The self-rated cosmetic disturbance was graded 10/10 on a verbal numeric scale...
April 2015: Journal of Bodywork and Movement Therapies
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