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Scheuermann's disease

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https://www.readbyqxmd.com/read/28640085/familial-lumbar-scheuermann-disease-with-idiopathic-scoliosis-in-china-first-case-report
#1
Yuliang Dai, Yawei Li, Pengzhi Li, Lei Li, Zhiming Tu, Bing Wang
RATIONALE: Given that Scheuermann disease rarely occurs in the lumbar region and that the co-occurrence of Scheuermann disease and idiopathic scoliosis (IS) has not been reported-the etiology of Scheuermann disease and IS is not clear. In this case report, we present familaiar lumbar Scheuermann disease with IS, in a Chinese proband, who was successfully treated with surgery. PATIENT CONCERNS: A 16-year-old boy presented at the Second XiangYa Hospital of Central South University with a chief complaint of kyphotic deformity in the lower back for 4 years and obvious lower back pain...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28434256/a-bioinformatics-roadmap-for-the-human-vaccines-project
#2
Richard H Scheuermann, Robert S Sinkovits, Theodore Schenkelberg, Wayne C Koff
Biomedical research has become a data intensive science in which high throughput experimentation is producing comprehensive data about biological systems at an ever-increasing pace. The Human Vaccines Project is a new public-private partnership, with the goal of accelerating development of improved vaccines and immunotherapies for global infectious diseases and cancers by decoding the human immune system. To achieve its mission, the Project is developing a Bioinformatics Hub as an open-source, multidisciplinary effort with the overarching goal of providing an enabling infrastructure to support the data processing, analysis and knowledge extraction procedures required to translate high throughput, high complexity human immunology research data into biomedical knowledge, to determine the core principles driving specific and durable protective immune responses...
May 9, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28420562/progression-of-untreated-mild-thoracic-scheuermann-s-kyphosis%C3%A2-%C3%A2-radiographic-and-functional-assessment-after-mean-follow-up-of-46%C3%A2-years
#3
Leena Ristolainen, Jyrki A Kettunen, Urho M Kujala, Ari Heinonen, Dietrich Schlenzka
BACKGROUND: There is no data available on the radiographic development of the Scheuermann's deformity. Our purpose was to investigate radiographic deformity progression and the relation between kyphosis progression and clinical outcome in patients with untreated Scheuermann's kyphosis. METHODS: Thoracic kyphosis (Th4-Th12) was measured from standing lateral radiographs in 19 patients at baseline and after mean 46-year follow-up. Mean age at baseline was 19.2 and at follow-up 64...
April 15, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28328806/craniosynostosis-scheuermann-s-disease-and-intellectual-disability-resembling-shprintzen-goldberg-syndrome-a-report-on-a-family-over-4-generations-case-report
#4
Ali Al Kaissi, Zahra Marrakchi, Nabil M Nassib, Jochen Hofstaetter, Franz Grill, Rudolf Ganger, Susanne Gerit Kircher
RATIONALE: Craniosynostosis is a disorder characterized by premature fusion of cranial sutures with subsequent development of abnormal craniofacial contour associated with variable skeletal and extra-skeletal abnormalities. In this family syndromic type of craniosynostosis was recognized and the etiology behind diverse forms of deformities have been diagnosed. PATIENT CONCERNS: The negative impact of the disorder on the child and his family is enormous. Particularly when the diagnosis is late and little can be done...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28302104/spinal-epidural-lipomatosis-an-easily-ignored-secondary-intraspinal-disorder-in-spinal-kyphotic-deformities
#5
Zhen Zhang, Zhen Liu, Zezhang Zhu, Yong Qiu
BACKGROUND: A previous study reported a high prevalence of spinal epidural lipomatosis (SEL) in patients with Scheuermann kyphosis (SK) and suggested that it may play a role in the pathogenesis of this disease. According to our observation, however, SEL occurs in other spinal kyphotic deformities as well. The aim of this study was to test the hypothesis that SEL commonly occurs in patients with different types of kyphotic deformities as a secondary intraspinal disorder. METHODS: MR images of 16 patients with congenital kyphosis (CK), 40 patients with SK, 13 patients with tuberculotic kyphosis (TK), and 69 age- and sex-matched controls were retrospectively evaluated...
March 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28194535/erratum-to-distal-junctional-kyphosis-in-patients-with-scheuermann-s-disease-a-retrospective-radiographic-analysis
#6
Amir Ghasemi, Timo Stubig, Luigi Aurelio Nasto, Malik Ahmed, Hossein Mehdian
No abstract text is available yet for this article.
February 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28141687/what-are-the-indications-for-spinal-fusion-surgery-in-scheuermann-kyphosis
#7
David W Polly, Charles G T Ledonio, Beverly Diamond, Hubert Labelle, Daniel J Sucato, M Timothy Hresko, John B Emans, Michael G Vitale, Mark A Erickson, A Noelle Larson
BACKGROUND: Surgical indications for Scheuermann kyphosis are variable. We sought to evaluate the characteristics of patients undergoing operative versus nonoperative treatment of Scheuermann kyphosis to better understand current practices and the factors which contribute to the decision for surgical management. METHODS: Multicenter prospective cohort study. We evaluated consecutive patients presenting with Scheuermann kyphosis. Patients underwent either surgical or nonoperative management according to surgeon and patient discretion...
January 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28131733/spinal-cord-ischemia-in-scheuermann-disease-a-report-of-three-cases
#8
Léa Chiche, Robert-Yves Carlier, Dan Siahou, Arnaud Nataf, Caroline Hugeron, Clémence Palazzo
BACKGROUND: Neurological complications in Scheuermann's disease are rare but serious. CASE REPORTS: We report three cases of severe neurological deficit due to medullar ischemia attributable to the compression of a radiculomedullar artery by thoracic (two cases) and lumbar (one case) disc herniations associated with Scheuermann's disease. They were not treated surgically because of the absence of direct spinal cord compression or definitive spinal cord ischemia...
May 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28040875/distal-junctional-kyphosis-in-patients-with-scheuermann-s-disease-a-retrospective-radiographic-analysis
#9
Amir Ghasemi, Timo Stubig, Luigi A Nasto, Malik Ahmed, Hossein Mehdian
PURPOSE: To investigate the relationship between preoperative and postoperative spinopelvic alignment and occurrence of DJK/DJF. STUDY DESIGN/SETTING: This was a retrospective observational cohort study. PATIENT SAMPLE: The sample included 40 patients who underwent posterior correction of SK from January 2006 to December 2014. OUTCOME MEASURES: Correlation analysis between the preoperative and postoperative spinopelvic alignment parameters and development of DJK over the course of the study period were studied...
March 2017: European Spine Journal
https://www.readbyqxmd.com/read/27941174/nocturnal-levels-of-chemerin-and-progranulin-in-adolescents-influence-of-sex-body-mass-index-glucose-metabolism-and-sleep
#10
Johann Daxer, Theresa Herttrich, Ying Y Zhao, Mandy Vogel, Andreas Hiemisch, Kathrin Scheuermann, Antje Körner, Jürgen Kratzsch, Wieland Kiess, Mirja Quante
BACKGROUND: Adipokines have been implicated in obesity, insulin resistance and sleep regulation. However, the role of chemerin and progranulin, two recently described adipokines, in the context of sleep remains unclear. The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism. METHODS: The study sample included 34 overweight/obese and 32 normal-weight adolescents from secondary schools and the Leipzig Research Center for Civilization Diseases (LIFE) Child study cohort...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27928471/radiological-imaging-findings-of-scheuermann-disease
#11
Erkan Gokce, Murat Beyhan
AIM: To find accompanying anomalies of typical and atypical Scheuermann's disease (SD) is reported in the present study. METHODS: Study included 20 patients (16 men and 4 women) who had radiological imaging radiography, magnetic resonance imaging (MRI) and computed tomography, if available, due to back pain, curved back and low back pain in November 2011-February 2016 period. Patients were categorized into typical and atypical patterns based on the region involved...
November 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27815125/meeting-report-29th-international-conference-on-antiviral-research-in-la-jolla-ca-usa
#12
REVIEW
R Anthony Vere Hodge
The 29th International Conference on Antiviral Research (ICAR) was held in La Jolla, CA, USA from April 17 to 21, 2016. This report opens with a tribute to the late Chris McGuigan, a Past-President of ISAR, then continues with summaries of the principal invited lectures. Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holý Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV...
January 2017: Antiviral Research
https://www.readbyqxmd.com/read/27785478/outcome-of-intensive-outpatient-rehabilitation-and-bracing-in-an-adult-patient-with-scheuermann-s-disease-evaluated-by-radiologic-imaging-a-case-report
#13
Hagit Berdishevsky
BACKGROUND: No studies examine the efficacy of intensive specific physical therapy (PT) exercises along with brace for the adult with Scheuermann's kyphosis (SK). The aim of this study was to examine the effects of intensive PT based on the Barcelona Scoliosis Physical Therapy School (BSPTS) and SpinoMed brace on a 76-year-old female with SK. CASE DESCRIPTION: A 76-year-old female, diagnosed with SK as an adolescent, presented in October 2014 with thoracic hyperkyphosis T1 to T12 Cobb angle of 85° and lumbar hyper lordosis L1 to L5 Cobb angle of 70°...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27785469/bracing-for-adolescent-idiopathic-scoliosis-ais-and-scheuermann-kyphosis-the-issue-of-overtreatment-in-greece
#14
Nikos S Karavidas
BACKGROUND: Most recent publications have provided evidence for brace treatment in spinal deformities. The purpose of this study was to evaluate the rate of overtreatment for AIS and Kyphosis in Greece, according to the Society on Scoliosis Orthopedic Rehabilitation Treatment (SOSORT) and the Scoliosis Research Society (SRS) guidelines for brace treatment. To date, this is the first study to investigate overtreatment percentage in a group of patients with spinal deformities. METHODS: Cross-sectional study design and data analysis were performed in a group of patients that received treatment in a private clinic, in 2014...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27688827/antioxidant-and-vasodilator-activity-of-ugni-molinae-turcz-murtilla-and-its-modulatory-mechanism-in-hypotensive-response
#15
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27679478/influenza-research-database-an-integrated-bioinformatics-resource-for-influenza-virus-research
#16
Yun Zhang, Brian D Aevermann, Tavis K Anderson, David F Burke, Gwenaelle Dauphin, Zhiping Gu, Sherry He, Sanjeev Kumar, Christopher N Larsen, Alexandra J Lee, Xiaomei Li, Catherine Macken, Colin Mahaffey, Brett E Pickett, Brian Reardon, Thomas Smith, Lucy Stewart, Christian Suloway, Guangyu Sun, Lei Tong, Amy L Vincent, Bryan Walters, Sam Zaremba, Hongtao Zhao, Liwei Zhou, Christian Zmasek, Edward B Klem, Richard H Scheuermann
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27548809/a-small-molecule-inhibitor-of-lin28
#17
Martina Roos, Ugo Pradère, Richard P Ngondo, Alok Behera, Sara Allegrini, Gianluca Civenni, Julian A Zagalak, Jean-Rémy Marchand, Mirjam Menzi, Harry Towbin, Jörg Scheuermann, Dario Neri, Amedeo Caflisch, Carlo V Catapano, Constance Ciaudo, Jonathan Hall
New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor suppressor is blocked by an RNA binding protein (RBP) Lin28, which docks onto a conserved sequence in let-7 precursor RNA molecules and prevents their maturation. Thus, the Lin28/let-7 interaction might be an attractive drug target, if not for the well-known difficulty in targeting RNA-protein interactions with drugs. Here, we describe a protein/RNA FRET assay using a GFP-Lin28 donor and a black-hole quencher (BHQ)-labeled let-7 acceptor, a fluorescent protein/quencher combination which is rarely used in screening despite favorable spectral properties...
October 21, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27384777/anterior-release-for-scheuermann-s-disease-a-systematic-literature-review-and-meta-analysis
#18
Cao Yun, Cai Liang Shen
PURPOSE: Anterior release for Scheuermann's disease was considered an important technique for decades. However, posterior-only surgery for Scheuermann's disease has shown a promising potential to manage this deformity, as well. Correction loss could happen post-operatively, especially when posterior-only surgery is performed in the early days. Therefore, a dispute regarding anterior release for Scheuermann's disease exists. METHODS: We performed a systematic review of studies, reporting the outcomes of anterior release and posterior fusion surgery (AP group) or posterior-only surgery (PO group) for Scheuermann's disease...
July 6, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27070038/-the-application-of-osteoscintigraphy-in-forensic-medical-practice-for-the-detection-and-differentiation-of-bone-fractures-in-the-living-human
#19
A A Gusarov, V A Fetisov, T A Kuprina
This paper is designed to present an example from the domestic expert practice with the successful application of the radionuclide technique to visualize the bone lesions in a victim of a traffic accident having concomitant pathology of the osseous-articular apparatus (Scheuermann-Mau disease). The use of the osteoscintigraphic method made it possible not only to confirm the injury to the spinal column and the sternum but also to ensure its differential diagnostics from the concurrent pathology. Also, the method allowed to detect the exact location of the fractures...
March 2016: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/27050577/identification-of-a-pi9-containing-rice-germplasm-with-a-newly-developed-robust-marker
#20
Klaus Konrad Scheuermann, Yulin Jia
The Pi9 gene in rice, originating from Oryza minuta, is an effective resistance gene for controlling rice blast disease. However, currently available linked DNA markers do not accurately identify the function of Pi9, thus hindering its efficient incorporation into new cultivars through marker-assisted selection (MAS). In addition, no known Pi9-containing rice germplasm is available to breeders. In the present study, DNA sequence variation of Pi9 alleles and their family members was analyzed in 40 diverse rice germplasm accessions from the AA genome to develop a robust Pi9 marker...
August 2016: Phytopathology
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