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https://www.readbyqxmd.com/read/28220596/quantitative-pcr-is-a-valuable-tool-to-monitor-performance-of-dna-encoded-chemical-library-selections
#1
Yizhou Li, Gunther Zimmermann, Jörg Scheuermann, Dario Neri
Phage-display libraries and DNA-encoded chemical libraries (DECL) represent useful tools for the isolation of specific binding molecules out of large combinatorial sets of compounds. In both methods, specific binders are recovered at the end of affinity capture procedures, using target proteins of interest immobilized on a solid support. However, while the efficiency of phage-display selections is routinely quantified by counting the phage titer before and after the affinity capture step, no similar quantification procedures have been reported for the characterization of DNA-encoded chemical library selections...
February 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28194535/erratum-to-distal-junctional-kyphosis-in-patients-with-scheuermann-s-disease-a-retrospective-radiographic-analysis
#2
Amir Ghasemi, Timo Stubig, Luigi Aurelio Nasto, Malik Ahmed, Hossein Mehdian
No abstract text is available yet for this article.
February 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28141687/what-are-the-indications-for-spinal-fusion-surgery-in-scheuermann-kyphosis
#3
David W Polly, Charles G T Ledonio, Beverly Diamond, Hubert Labelle, Daniel J Sucato, M Timothy Hresko, John B Emans, Michael G Vitale, Mark A Erickson, A Noelle Larson
BACKGROUND: Surgical indications for Scheuermann kyphosis are variable. We sought to evaluate the characteristics of patients undergoing operative versus nonoperative treatment of Scheuermann kyphosis to better understand current practices and the factors which contribute to the decision for surgical management. METHODS: Multicenter prospective cohort study. We evaluated consecutive patients presenting with Scheuermann kyphosis. Patients underwent either surgical or nonoperative management according to surgeon and patient discretion...
January 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28131733/spinal-cord-ischemia-in-scheuermann-disease-a-report-of-three-cases
#4
Léa Chiche, Robert-Yves Carlier, Dan Siahou, Arnaud Nataf, Caroline Hugeron, Clémence Palazzo
BACKGROUND: Neurological complications in Scheuermann's disease are rare but serious. CASE REPORTS: We report three cases of severe neurological deficit due to medullar ischemia attributable to the compression of a radiculomedullar artery by thoracic (two cases) and lumbar (one case) disc herniations associated with Scheuermann's disease. They were not treated surgically because of the absence of direct spinal cord compression or definitive spinal cord ischemia...
January 25, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28125631/comprehensive-annotation-of-mature-peptides-and-genotypes-for-zika-virus
#5
Guangyu Sun, Christopher N Larsen, Nicole Baumgarth, Edward B Klem, Richard H Scheuermann
The rapid spread of Zika virus (ZIKV) has caused much concern in the global health community, due in part to a link to fetal microcephaly and other neurological illnesses. While an increasing amount of ZIKV genomic sequence data is being generated, an understanding of the virus molecular biology is still greatly lacking. A significant step towards establishing ZIKV proteomics would be the compilation of all proteins produced by the virus, and the resultant virus genotypes. Here we report for the first time such data, using new computational methods for the annotation of mature peptide proteins, genotypes, and recombination events for all ZIKV genomes...
2017: PloS One
https://www.readbyqxmd.com/read/28069807/an-integrated-workflow-to-assess-technical-and-biological-variability-of-cell-population-frequencies-in-human-peripheral-blood-by-flow-cytometry
#6
Julie G Burel, Yu Qian, Cecilia Lindestam Arlehamn, Daniela Weiskopf, Jose Zapardiel-Gonzalo, Randy Taplitz, Robert H Gilman, Mayuko Saito, Aruna D de Silva, Pandurangan Vijayanand, Richard H Scheuermann, Alessandro Sette, Bjoern Peters
In the context of large-scale human system immunology studies, controlling for technical and biological variability is crucial to ensure that experimental data support research conclusions. In this study, we report on a universal workflow to evaluate both technical and biological variation in multiparameter flow cytometry, applied to the development of a 10-color panel to identify all major cell populations and T cell subsets in cryopreserved PBMC. Replicate runs from a control donation and comparison of different gating strategies assessed the technical variability associated with each cell population and permitted the calculation of a quality control score...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28067010/hit-validation-methodologies-for-ligands-isolated-from-dna-encoded-chemical-libraries
#7
Gunther Zimmermann, Yizhou Li, Ulrike Rieder, Martin Mattarella, Dario Neri, Jörg Scheuermann
DNA-encoded chemical libraries (DECLs) are large collections of compounds linked to DNA fragments, serving as amplifiable barcodes, which can be screened on target proteins of interest. In typical DECL selections, preferential binders are identified by high-throughput DNA sequencing, comparing their frequency before and after the affinity capture step. Hits identified in this procedure need to be confirmed, by resynthesis and by performing affinity measurements. In this article, we present novel methods, based on the hybridization of oligonucleotide conjugates with fluorescently-labeled complementary oligonucleotides, which facilitate the determination of affinity constants and kinetic dissociation constants...
January 9, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28048717/mo-fg-202-09-virtual-imrt-qa-using-machine-learning-a-multi-institutional-validation
#8
G Valdes, M Chan, R Scheuermann, J Deasy, T Solberg
PURPOSE: To validate a machine learning approach to Virtual IMRT QA for accurately predicting gamma passing rates using different QA devices at different institutions. METHODS: A Virtual IMRT QA was constructed using a machine learning algorithm based on 416 IMRT plans, in which QA measurements were performed using diode-array detectors and a 3%local/3mm with 10% threshold. An independent set of 139 IMRT measurements from a different institution, with QA data based on portal dosimetry using the same gamma index and 10% threshold, was used to further test the algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046344/mo-ab-bra-07-low-dose-imaging-with-avalanche-amorphous-selenium-flat-panel-imager
#9
J Scheuermann, A Howansky, A Goldan, S Leveille, O Tousignant, K Tanioka, W Zhao
PURPOSE: We present the first active matrix flat panel imager (AMFPI) capable of producing x-ray quantum noise limited images at low doses by overcoming the electronic noise through signal amplification by photoconductive avalanche gain (gav). The indirect detector fabricated uses an optical sensing layer of amorphous selenium (a-Se) known as High-Gain Avalanche Rushing Photoconductor (HARP). The detector design is called Scintillator HARP (SHARP)-AMFPI. This is the first image sensor to utilize solid-state HARP technology...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040875/distal-junctional-kyphosis-in-patients-with-scheuermann-s-disease-a-retrospective-radiographic-analysis
#10
Amir Ghasemi, Timo Stubig, Luigi A Nasto, Malik Ahmed, Hossein Mehdian
PURPOSE: To investigate the relationship between preoperative and postoperative spinopelvic alignment and occurrence of DJK/DJF. STUDY DESIGN/SETTING: This was a retrospective observational cohort study. PATIENT SAMPLE: The sample included 40 patients who underwent posterior correction of SK from January 2006 to December 2014. OUTCOME MEASURES: Correlation analysis between the preoperative and postoperative spinopelvic alignment parameters and development of DJK over the course of the study period were studied...
December 31, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28013270/impact-of-the-2015-cms-inpatient-psychiatric-facility-quality-reporting-ipfqr-rule-on-tobacco-treatment
#11
Shane Carrillo, Niaman Nazir, Eric Howser, Lisa Shenkman, Melinda Laxson, Taenisha S Scheuermann, Kimber P Richter
INTRODUCTION: In its fiscal year (FY) 2015 final rule, the Centers for Medicare & Medicaid (CMS) required reporting of tobacco treatment quality measures as part of the Inpatient Psychiatric Facilities Prospective Payment System (IPF PPS). This pre-intervention, post-intervention policy analysis evaluates the impact of that policy at a large academic medical center that opted to improve performance as it implemented reporting measures. METHODS: Electronic medical record data were collected retrospectively for all adult (≥18 years) inpatient psychiatric admissions from January 1(st) 2014 to December 31(st) 2015...
December 24, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27981236/a-phylogeny-based-global-nomenclature-system-and-automated-annotation-tool-for-h1-hemagglutinin-genes-from-swine-influenza-a-viruses
#12
Tavis K Anderson, Catherine A Macken, Nicola S Lewis, Richard H Scheuermann, Kristien Van Reeth, Ian H Brown, Sabrina L Swenson, Gaëlle Simon, Takehiko Saito, Yohannes Berhane, Janice Ciacci-Zanella, Ariel Pereda, C Todd Davis, Ruben O Donis, Richard J Webby, Amy L Vincent
The H1 subtype of influenza A viruses (IAVs) has been circulating in swine since the 1918 human influenza pandemic. Over time, and aided by further introductions from nonswine hosts, swine H1 viruses have diversified into three genetic lineages. Due to limited global data, these H1 lineages were named based on colloquial context, leading to a proliferation of inconsistent regional naming conventions. In this study, we propose rigorous phylogenetic criteria to establish a globally consistent nomenclature of swine H1 virus hemagglutinin (HA) evolution...
November 2016: MSphere
https://www.readbyqxmd.com/read/27941174/nocturnal-levels-of-chemerin-and-progranulin-in-adolescents-influence-of-sex-body-mass-index-glucose-metabolism-and-sleep
#13
Johann Daxer, Theresa Herttrich, Ying Y Zhao, Mandy Vogel, Andreas Hiemisch, Kathrin Scheuermann, Antje Körner, Jürgen Kratzsch, Wieland Kiess, Mirja Quante
BACKGROUND: Adipokines have been implicated in obesity, insulin resistance and sleep regulation. However, the role of chemerin and progranulin, two recently described adipokines, in the context of sleep remains unclear. The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism. METHODS: The study sample included 34 overweight/obese and 32 normal-weight adolescents from secondary schools and the Leipzig Research Center for Civilization Diseases (LIFE) Child study cohort...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27932075/non-enzymatic-oxidized-metabolite-of-dha-4-rs-4-f4t-neuroprostane-protects-the-heart-against-reperfusion-injury
#14
Jérôme Roy, Jérémy Fauconnier, Camille Oger, Charlotte Farah, Claire Angebault-Prouteau, Jérôme Thireau, Patrice Bideaux, Valérie Scheuermann, Valérie Bultel-Poncé, Marie Demion, Jean-Marie Galano, Thierry Durand, Jetty Chung-Yung Lee, Jean-Yves Le Guennec
Acute myocardial infarction leads to an increase in oxidative stress and lipid peroxidation. 4(RS)-4-F4t-Neuroprostane (4-F4t-NeuroP) is a mediator produced by non-enzymatic free radical peroxidation of the cardioprotective polyunsaturated fatty acid, docosahexaenoic acid (DHA). In this study, we investigated whether intra-cardiac delivery of 4-F4t-NeuroP (0.03mg/kg) prior to occlusion (ischemia) prevents and protects rat myocardium from reperfusion damages. Using a rat model of ischemic-reperfusion (I/R), we showed that intra-cardiac infusion of 4-F4t-NeuroP significantly decreased infarct size following reperfusion (-27%) and also reduced ventricular arrhythmia score considerably during reperfusion (-41%)...
January 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27928471/radiological-imaging-findings-of-scheuermann-disease
#15
Erkan Gokce, Murat Beyhan
AIM: To find accompanying anomalies of typical and atypical Scheuermann's disease (SD) is reported in the present study. METHODS: Study included 20 patients (16 men and 4 women) who had radiological imaging radiography, magnetic resonance imaging (MRI) and computed tomography, if available, due to back pain, curved back and low back pain in November 2011-February 2016 period. Patients were categorized into typical and atypical patterns based on the region involved...
November 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27904931/-arthroscopic-tenodesis-or-tenotomy-of-the-long-head-of-the-biceps-tendon-in-preselected-patients-does-it-make-a%C3%A2-difference
#16
M Kerschbaum, N Maziak, M Scheuermann, M Scheibel
BACKGROUND: Are there clinical, cosmetic and/or structural differences between tenotomy and tenodesis of the long head of the biceps tendon (LHB) in patients selected according to commonly used indication criteria? MATERIAL AND METHODS: A total of 85 patients were included in this study. An LHB tenodesis (LHB-TD) was performed in 49 patients and a tenotomy (LHB-TT) in 36 patients. In addition to a standardized examination, the age and gender adjusted Constant score (aCS), the LHB score and the subjective shoulder value (SSV) were assessed...
November 30, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27897007/production-of-a-preliminary-quality-control-pipeline-for-single-nuclei-rna-seq-and-its-application-in-the-analysis-of-cell-type-diversity-of-post-mortem-human-brain-neocortex
#17
Brian Aevermann, Jamison McCorrison, Pratap Venepally, Rebecca Hodge, Trygve Bakken, Jeremy Miller, Mark Novotny, Danny N Tran, Francisco Diezfuertes, Lena Christiansen, Fan Zhang, Frank Steemers, Roger S Lasken, E D Lein, Nicholas Schork, Richard H Scheuermann
Next generation sequencing of the RNA content of single cells or single nuclei (sc/nRNA-seq) has become a powerful approach to understand the cellular complexity and diversity of multicellular organisms and environmental ecosystems. However, the fact that the procedure begins with a relatively small amount of starting material, thereby pushing the limits of the laboratory procedures required, dictates that careful approaches for sample quality control (QC) are essential to reduce the impact of technical noise and sample bias in downstream analysis applications...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27858694/goniometric-evaluation-of-the-spinal-sagittal-curves-in-children-and-adolescents-a-reliability-study
#18
Aristide Gravina, Claudio Ferraro, Patrizia Poli, Michele Barazzuol, Alessandra Del Felice, Stefano Masiero
BACKGROUND: Gold standard for spine deformities assessment is X rays, but the procedure bears a risk of exposure. OBJECTIVE: To investigate intra-rater and inter-rater reliability of a pocket compass needle goniometer (IncliMed®, University of Padua) to non-invasively evaluate spine curves in children and adolescents. METHODS: Prospective reliability study in a paediatric population (mean age 12.5 years ± 2.5). Children with spine deformities (Scheuermann's or postural kyphosis, idiopathic scoliosis) and healthy controls were included...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27815125/meeting-report-29th-international-conference-on-antiviral-research-in-la-jolla-ca-usa
#19
REVIEW
R Anthony Vere Hodge
The 29th International Conference on Antiviral Research (ICAR) was held in La Jolla, CA, USA from April 17 to 21, 2016. This report opens with a tribute to the late Chris McGuigan, a Past-President of ISAR, then continues with summaries of the principal invited lectures. Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holý Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV...
January 2017: Antiviral Research
https://www.readbyqxmd.com/read/27785478/outcome-of-intensive-outpatient-rehabilitation-and-bracing-in-an-adult-patient-with-scheuermann-s-disease-evaluated-by-radiologic-imaging-a-case-report
#20
Hagit Berdishevsky
BACKGROUND: No studies examine the efficacy of intensive specific physical therapy (PT) exercises along with brace for the adult with Scheuermann's kyphosis (SK). The aim of this study was to examine the effects of intensive PT based on the Barcelona Scoliosis Physical Therapy School (BSPTS) and SpinoMed brace on a 76-year-old female with SK. CASE DESCRIPTION: A 76-year-old female, diagnosed with SK as an adolescent, presented in October 2014 with thoracic hyperkyphosis T1 to T12 Cobb angle of 85° and lumbar hyper lordosis L1 to L5 Cobb angle of 70°...
2016: Scoliosis and Spinal Disorders
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