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https://www.readbyqxmd.com/read/29208285/hybrid-nanofibers-based-on-poly-caprolactone-gelatin-hydroxyapatite-nanoparticles-loaded-doxycycline-effective-anti-tumoral-and-antibacterial-activity
#1
Ricardo Ramírez-Agudelo, Karina Scheuermann, Alfonso Gala-García, Ana Paula F Monteiro, Ana Delia Pinzón-García, Maria E Cortés, Rubén D Sinisterra
Cancer is one of the leading causes of morbidity and mortality Worldwide, 19.3 million new cancer cases are expected to be identified in 2025. Among the therapeutic arsenal to cancer control one could find the Doxycycline and the nano hydroxyapatite. The Doxycycline (Dox) not only shown antibiotic effect but also exhibits a wide range of pleiotropic therapeutic properties as the control of the invasive and metastatic cancer cells characteristics. The purpose of the present study was to evaluate both cytotoxicity in vitro and antibacterial activity of electrospun Dox-loaded hybrid nanofibrous scaffolds composed by hydroxyapatite nanoparticles (nHA), poly-ε-caprolactone (PCL) and gelatin (Gel) polymers...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29189571/adding-satellite-rods-to-standard-2-rod-construct-with-the-use-of-duet-screws-an-effective-technique-to-improve-surgical-outcomes-and-preventing-proximal-junctional-kyphosis-in-posterior-only-correction-of-scheuermann-kyphosis
#2
Ze-Zhang Zhu, Xi Chen, Yong Qiu, Zhong-Hui Chen, Song Li, Liang Xu, Xu Sun
STUDY DESIGN: Retrospective matched-cohort comparative study. OBJECTIVE: To compare the surgical results after the use of duet screw based satellite rods plus bilateral satellite rods (S-RC) versus a standard 2-rod construct (2-RC) across osteotomy sites in a matched-cohort with Scheuermann kyphosis (SK). SUMMARY OF BACKGROUND DATA: Multiple Ponte osteotomies are frequently employed to correct SK via a posterior-only approach, with a 2-RC across the osteotomy sites...
November 17, 2017: Spine
https://www.readbyqxmd.com/read/29171067/towards-scintillator-high-gain-avalanche-rushing-photoconductor-active-matrix-flat-panel-imager-sharp-amfpi-initial-fabrication-and-characterization
#3
James R Scheuermann, Adrian Howansky, Marc Hansroul, Sébastien Léveillé, Kenkichi Tanioka, Wei Zhao
PURPOSE: We present the first prototype Scintillator High Gain Avalanche Rushing Photoconductor Active Matrix Flat Panel Imager (SHARP-AMFPI). This detector includes a layer of avalanche amorphous Selenium (a-Se) (HARP) as the photoconductor in an indirect detector to amplify the signal and reduce the effects of electronic noise to obtain quantum noise limited images for low dose applications. It is the first time avalanche a-Se has been used in a solid-state imaging device and poses as a possible solution to eliminate the effects of electronic noise, which is crucial for low-dose imaging performance of AMFPI...
November 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/29150740/severe-rigid-scheuermann-kyphosis-in-adult-patients-correction-with-posterior-only-approach
#4
B Mirzashahi, M Chehrassan, A Arfa, M Farzan
PURPOSE: Scheuermann kyphosis is the most common structural kyphosis among adolescence and young people. Surgical treatment may be performed through combined anterior and posterior or posterior-only approaches; to our knowledge, the efficacy of posterior-only approach as less invasive procedure is not well studied in case of severe rigid Scheuermann kyphosis. MATERIALS AND METHODS: Eighteen patients with severe rigid Scheuermann kyphosis operated through only posterior approach from 2013 to 2016 were evaluated...
November 17, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29128077/automated-analysis-of-clinical-flow-cytometry-data-a-chronic-lymphocytic-leukemia-illustration
#5
REVIEW
Richard H Scheuermann, Jack Bui, Huan-You Wang, Yu Qian
Flow cytometry is used in cell-based diagnostic evaluation for blood-borne malignancies including leukemia and lymphoma. The current practice for cytometry data analysis relies on manual gating to identify cell subsets in complex mixtures, which is subjective, labor-intensive, and poorly reproducible. This article reviews recent efforts to develop, validate, and disseminate automated computational methods and pipelines for cytometry data analysis that could help overcome the limitations of manual analysis and provide for efficient and data-driven diagnostic applications...
December 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29035089/intent-to-quit-quit-attempts-and-perceived-health-risk-reduction-among-african-american-latino-and-white-nondaily-and-daily-smokers-in-the-united-states
#6
Taneisha S Scheuermann, Nicole L Nollen, Xianghua Luo, Lisa Sanderson Cox, Jasjit S Ahluwalia
OBJECTIVE: Ethnic and racial differences in smoking patterns and behaviors have been well documented and most African American and Latino smokers are nondaily or light smokers. However, differences within smoking levels are understudied. Our primary aim was to determine whether there are racial and ethnic differences among African American, Latino, and White nondaily, light daily, and moderate to heavy daily smokers on (1) perceived health risk reduction, (2) intentions to quit, and (3) past year quit attempts...
October 16, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29020925/vdjpipe-a-pipelined-tool-for-pre-processing-immune-repertoire-sequencing-data
#7
Scott Christley, Mikhail K Levin, Inimary T Toby, John M Fonner, Nancy L Monson, William H Rounds, Florian Rubelt, Walter Scarborough, Richard H Scheuermann, Lindsay G Cowell
BACKGROUND: Pre-processing of high-throughput sequencing data for immune repertoire profiling is essential to insure high quality input for downstream analysis. VDJPipe is a flexible, high-performance tool that can perform multiple pre-processing tasks with just a single pass over the data files. RESULTS: Processing tasks provided by VDJPipe include base composition statistics calculation, read quality statistics calculation, quality filtering, homopolymer filtering, length and nucleotide filtering, paired-read merging, barcode demultiplexing, 5' and 3' PCR primer matching, and duplicate reads collapsing...
October 11, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28964216/the-new-versatile-general-purpose-surface-muon-instrument-gps-based-on-silicon-photomultipliers-for-%C3%AE-sr-measurements-on-a-continuous-wave-beam
#8
A Amato, H Luetkens, K Sedlak, A Stoykov, R Scheuermann, M Elender, A Raselli, D Graf
We report on the design and commissioning of a new spectrometer for muon-spin relaxation/rotation studies installed at the Swiss Muon Source (SμS) of the Paul Scherrer Institute (PSI, Switzerland). This new instrument is essentially a new design and replaces the old general-purpose surface-muon (GPS) instrument that has been for long the workhorse of the μSR user facility at PSI. By making use of muon and positron detectors made of plastic scintillators read out by silicon photomultipliers, a time resolution of the complete instrument of about 160 ps (standard deviation) could be achieved...
September 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28944578/impact-of-a-central-scaffold-on-the-binding-affinity-of-fragment-pairs-isolated-from-dna-encoded-self-assembling-chemical-libraries
#9
Martina Bigatti, Alberto Dal Corso, Sara Vanetti, Samuele Cazzamalli, Ulrike Rieder, Jörg Scheuermann, Dario Neri, Filippo Sladojevich
The screening of encoded self-assembling chemical libraries allows the identification of fragment pairs that bind to adjacent pockets on target proteins of interest. For practical applications, it is necessary to link these ligand pairs into discrete organic molecules, devoid of any nucleic acid component. Here we describe the discovery of a synergistic binding pair for acid alpha-1 glycoprotein and a chemical strategy for the identification of optimal linkers, connecting the two fragments. The procedure yielded a set of small organic ligands, the best of which exhibited a dissociation constant of 9...
September 24, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28935874/concordant-and-discordant-gene-expression-patterns-in-mouse-strains-identify-best-fit-animal-model-for-human-tuberculosis
#10
Teresa Domaszewska, Lisa Scheuermann, Karin Hahnke, Hans Mollenkopf, Anca Dorhoi, Stefan H E Kaufmann, January Weiner
Immunity in infection, inflammation and malignancy differs markedly in man and mouse. Still, we learn about human immunity in large extent from experimental mouse models. We propose a novel data integration approach which identifies concordant and discordant gene expression patterns of the immune responses in heterologous data sets. We have conducted experiments to compare human and murine transcriptional responses to Mycobacterium tuberculosis (Mtb) infection in whole blood (WB) as well as macrophages and compared them with simulated as well as publicly available data...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888389/scheuermann-s-disease-in-a-juvenile-male-from-the-late-roman-necropolis-of-torrenueva-3rd-4th-century-ce-granada-spain
#11
Joan Viciano, Sandra López-Lázaro, Ángela Pérez-Fernández, Anabel Amores-Ampuero, Ruggero D'Anastasio, José Miguel Jiménez-Triguero
This study details a severe case of Scheuermann's disease (SD) in a well-preserved skeleton of a juvenile male (designated TOR302), dated to 3rd-4th century CE, from the late Roman necropolis of Torrenueva (Granada, Spain). Individual TOR302 shows an evident kyphotic curve in the thoraco-lumbar spine, which is characterised by: (i) vertebral bodies of thoracic vertebra T2, thoracic segment T4-T9, and thoraco-lumbar segment T12-L2 wedged at >5°; (ii) slight anterior extensions of the epiphyseal ring; (iii) Schmorl's nodes on the superior and/or inferior plates; and (iv) a Cobb angle of 75°, derived from thoracic segments T4-T9...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28874968/posterior-only-approach-with-pedicle-screws-for-the-correction-of-scheuermann-s-kyphosis
#12
Adem Cobden, Akif Albayrak, Yalkin Camurcu, Hakan Sofu, Temel Tacal, Mehmet Akif Kaygusuz
STUDY DESIGN: Retrospective study (level of evidence: level 3). PURPOSE: The purpose of this study was to evaluate the clinical and radiological results of the posterior-only approach with pedicle screws for the treatment of Scheuermann's kyphosis (SK). OVERVIEW OF LITERATURE: The correction of SK with instrumentation can be performed using posterior-only or combined anterior-posterior procedures. With the use of all-pedicle screw constructs in spine surgery, the posterior-only approach has become a popular option for the definitive treatment of SK...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28854499/persian-adaptation-of-quality-of-life-profile-for-spinal-deformities-questionnaire
#13
Fazel Rezaei Motlagh, Mohammad Kamali, Taher Babaee
BACKGROUND: The Quality of Life Profile for Spinal Deformities (QLPSD) is the first specific questionnaire to evaluate health-related quality-of-life (HRQoL) in adolescents with spinal deformities. Measuring HRQoL is important because spinal deformities and their management may negatively affect quality of life (QoL), thereby importantly affecting treatment effectiveness. OBJECTIVE: This study aimed to examine the validity and reliability of a Persian version of the QLPSD through patients with adolescent idiopathic scoliosis and Scheuermann's kyphosis...
August 12, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28837586/nampt-serum-levels-are-selectively-elevated-in-acute-infectious-disease-and-in-acute-relapse-of-chronic-inflammatory-diseases-in-children
#14
Julia Gesing, Kathrin Scheuermann, Isabel Viola Wagner, Dennis Löffler, Daniela Friebe, Wieland Kiess, Volker Schuster, Antje Körner
Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, not clear whether this association reflects a chronic elevation or acute inflammatory response. We analyzed NAMPT concentrations in distinct states of inflammation in 102 children and found consistently significantly increased NAMPT levels in subjects with acute infections...
2017: PloS One
https://www.readbyqxmd.com/read/28834608/accuracy-of-self-reported-smoking-abstinence-in-clinical-trials-of-hospital-initiated-smoking-interventions
#15
Taneisha S Scheuermann, Kimber P Richter, Nancy A Rigotti, Sharon E Cummins, Kathleen F Harrington, Scott E Sherman, Shu-Hong Zhu, Hilary A Tindle, Kristopher J Preacher
AIMS: To estimate the prevalence and predictors of failed biochemical verification of self-reported abstinence among participants enrolled in trials of hospital-initiated smoking cessation interventions. DESIGN: Comparison of characteristics between participants who verified and those who failed to verify self-reported abstinence. SETTINGS: Multi-site randomized clinical trials conducted between 2010 and 2014 in hospitals throughout the United States...
December 2017: Addiction
https://www.readbyqxmd.com/read/28815994/imrt-qa-using-machine-learning-a-multi-institutional-validation
#16
Gilmer Valdes, Maria F Chan, Seng Boh Lim, Ryan Scheuermann, Joseph O Deasy, Timothy D Solberg
PURPOSE: To validate a machine learning approach to Virtual intensity-modulated radiation therapy (IMRT) quality assurance (QA) for accurately predicting gamma passing rates using different measurement approaches at different institutions. METHODS: A Virtual IMRT QA framework was previously developed using a machine learning algorithm based on 498 IMRT plans, in which QA measurements were performed using diode-array detectors and a 3%local/3 mm with 10% threshold at Institution 1...
August 17, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28806908/changing-the-default-for-tobacco-cessation-treatment-in-an-inpatient-setting-study-protocol-of-a-randomized-controlled-trial
#17
Babalola Faseru, Edward F Ellerbeck, Delwyn Catley, Byron J Gajewski, Taneisha S Scheuermann, Theresa I Shireman, Laura M Mussulman, Niaman Nazir, Terry Bush, Kimber P Richter
BACKGROUND: Most health care providers do not treat tobacco dependence routinely. This may in part be due to the treatment "default." Current treatment guidelines recommend that providers (1) ask patients if they are willing to quit and (2) provide cessation-focused medications and counseling only to smokers who state that they are willing to quit. The default is that patients have to "opt in" to receive cessation assistance: providers ask smokers if they are willing to quit, and only offer medications and cessation support to those who say "yes...
August 14, 2017: Trials
https://www.readbyqxmd.com/read/28798746/automated-analysis-of-flow-cytometry-data-to-reduce-inter-lab-variation-in-the-detection-of-major-histocompatibility-complex-multimer-binding-t-cells
#18
Natasja Wulff Pedersen, P Anoop Chandran, Yu Qian, Jonathan Rebhahn, Nadia Viborg Petersen, Mathilde Dalsgaard Hoff, Scott White, Alexandra J Lee, Rick Stanton, Charlotte Halgreen, Kivin Jakobsen, Tim Mosmann, Cécile Gouttefangeas, Cliburn Chan, Richard H Scheuermann, Sine Reker Hadrup
Manual analysis of flow cytometry data and subjective gate-border decisions taken by individuals continue to be a source of variation in the assessment of antigen-specific T cells when comparing data across laboratories, and also over time in individual labs. Therefore, strategies to provide automated analysis of major histocompatibility complex (MHC) multimer-binding T cells represent an attractive solution to decrease subjectivity and technical variation. The challenge of using an automated analysis approach is that MHC multimer-binding T cell populations are often rare and therefore difficult to detect...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28780647/cardiovascular-responses-to-skeletal-muscle-stretching-stretching-the-truth-or-a-new-exercise-paradigm-for-cardiovascular-medicine
#19
REVIEW
Nicholas T Kruse, Barry W Scheuermann
Stretching is commonly prescribed with the intended purpose of increasing range of motion, enhancing muscular coordination, and preventing prolonged immobilization induced by aging or a sedentary lifestyle. Emerging evidence suggests that acute or long-term stretching exercise may modulate a variety of cardiovascular responses. Specifically, at the onset of stretch, the mechanical deformation of the vascular bed coupled with stimulation of group III muscle afferent fibers initiates a cascade of events resulting in both peripheral vasodilation and a heart rate-driven increase in cardiac output, blood pressure, and muscle blood flow...
December 2017: Sports Medicine
https://www.readbyqxmd.com/read/28746130/can-mri-predict-flexibility-in-scheuermann-kyphosis-patients
#20
Radek Kaiser, Eyal Behrbalk, Michael Walsh, Petr Waldauf, Ana B Perez Romera, Hossein Mehdian
STUDY DESIGN: Retrospective, blinded analysis of imaging studies. OBJECTIVE: The aim of this study is compare the use of magnetic resonance imaging (MRI) to lateral radiograph using bolster in the evaluation of Scheuermann kyphosis (SK) curve flexibility measurement. SUMMARY AND BACKGROUND DATA: The flexibility of the thoracic curve [thoracic kyphosis (TK)] in SK is of primary importance in its preoperative planning. Several methods have been described for SK curve flexibility measurement...
August 2017: Clinical Spine Surgery
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