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https://www.readbyqxmd.com/read/28069807/an-integrated-workflow-to-assess-technical-and-biological-variability-of-cell-population-frequencies-in-human-peripheral-blood-by-flow-cytometry
#1
Julie G Burel, Yu Qian, Cecilia Lindestam Arlehamn, Daniela Weiskopf, Jose Zapardiel-Gonzalo, Randy Taplitz, Robert H Gilman, Mayuko Saito, Aruna D de Silva, Pandurangan Vijayanand, Richard H Scheuermann, Alessandro Sette, Bjoern Peters
In the context of large-scale human system immunology studies, controlling for technical and biological variability is crucial to ensure that experimental data support research conclusions. In this study, we report on a universal workflow to evaluate both technical and biological variation in multiparameter flow cytometry, applied to the development of a 10-color panel to identify all major cell populations and T cell subsets in cryopreserved PBMC. Replicate runs from a control donation and comparison of different gating strategies assessed the technical variability associated with each cell population and permitted the calculation of a quality control score...
January 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28067010/hit-validation-methodologies-for-ligands-isolated-from-dna-encoded-chemical-libraries
#2
Gunther Zimmermann, Yizhou Li, Ulrike Rieder, Martin Mattarella, Dario Neri, Jörg Scheuermann
DNA-encoded chemical libraries (DECLs) are large collections of compounds linked to DNA fragments, serving as amplifiable barcodes, which can be screened on target proteins of interest. In typical DECL selections, preferential binders are identified by high-throughput DNA sequencing, comparing their frequency before and after the affinity capture step. Hits identified in this procedure need to be confirmed, by resynthesis and by performing affinity measurements. In this article, we present novel methods, based on the hybridization of oligonucleotide conjugates with fluorescently-labeled complementary oligonucleotides, which facilitate the determination of affinity constants and kinetic dissociation constants...
January 9, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28048717/mo-fg-202-09-virtual-imrt-qa-using-machine-learning-a-multi-institutional-validation
#3
G Valdes, M Chan, R Scheuermann, J Deasy, T Solberg
PURPOSE: To validate a machine learning approach to Virtual IMRT QA for accurately predicting gamma passing rates using different QA devices at different institutions. METHODS: A Virtual IMRT QA was constructed using a machine learning algorithm based on 416 IMRT plans, in which QA measurements were performed using diode-array detectors and a 3%local/3mm with 10% threshold. An independent set of 139 IMRT measurements from a different institution, with QA data based on portal dosimetry using the same gamma index and 10% threshold, was used to further test the algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046344/mo-ab-bra-07-low-dose-imaging-with-avalanche-amorphous-selenium-flat-panel-imager
#4
J Scheuermann, A Howansky, A Goldan, S Leveille, O Tousignant, K Tanioka, W Zhao
PURPOSE: We present the first active matrix flat panel imager (AMFPI) capable of producing x-ray quantum noise limited images at low doses by overcoming the electronic noise through signal amplification by photoconductive avalanche gain (gav). The indirect detector fabricated uses an optical sensing layer of amorphous selenium (a-Se) known as High-Gain Avalanche Rushing Photoconductor (HARP). The detector design is called Scintillator HARP (SHARP)-AMFPI. This is the first image sensor to utilize solid-state HARP technology...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040875/distal-junctional-kyphosis-in-patients-with-scheuermann-s-disease-a-retrospective-radiographic-analysis
#5
Amir Ghasemi, Timo Stubig, Luigi A Nasto, Malik Ahmed, Hossein Mehdian
PURPOSE: To investigate the relationship between preoperative and postoperative spinopelvic alignment and occurrence of DJK/DJF. STUDY DESIGN/SETTING: This was a retrospective observational cohort study. PATIENT SAMPLE: The sample included 40 patients who underwent posterior correction of SK from January 2006 to December 2014. OUTCOME MEASURES: Correlation analysis between the preoperative and postoperative spinopelvic alignment parameters and development of DJK over the course of the study period were studied...
December 31, 2016: European Spine Journal
https://www.readbyqxmd.com/read/28013270/impact-of-the-2015-cms-inpatient-psychiatric-facility-quality-reporting-ipfqr-rule-on-tobacco-treatment
#6
Shane Carrillo, Niaman Nazir, Eric Howser, Lisa Shenkman, Melinda Laxson, Taenisha S Scheuermann, Kimber P Richter
INTRODUCTION: In its fiscal year (FY) 2015 final rule, the Centers for Medicare & Medicaid (CMS) required reporting of tobacco treatment quality measures as part of the Inpatient Psychiatric Facilities Prospective Payment System (IPF PPS). This pre-intervention, post-intervention policy analysis evaluates the impact of that policy at a large academic medical center that opted to improve performance as it implemented reporting measures. METHODS: Electronic medical record data were collected retrospectively for all adult (≥18 years) inpatient psychiatric admissions from January 1(st) 2014 to December 31(st) 2015...
December 24, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27981236/a-phylogeny-based-global-nomenclature-system-and-automated-annotation-tool-for-h1-hemagglutinin-genes-from-swine-influenza-a-viruses
#7
Tavis K Anderson, Catherine A Macken, Nicola S Lewis, Richard H Scheuermann, Kristien Van Reeth, Ian H Brown, Sabrina L Swenson, Gaëlle Simon, Takehiko Saito, Yohannes Berhane, Janice Ciacci-Zanella, Ariel Pereda, C Todd Davis, Ruben O Donis, Richard J Webby, Amy L Vincent
The H1 subtype of influenza A viruses (IAVs) has been circulating in swine since the 1918 human influenza pandemic. Over time, and aided by further introductions from nonswine hosts, swine H1 viruses have diversified into three genetic lineages. Due to limited global data, these H1 lineages were named based on colloquial context, leading to a proliferation of inconsistent regional naming conventions. In this study, we propose rigorous phylogenetic criteria to establish a globally consistent nomenclature of swine H1 virus hemagglutinin (HA) evolution...
November 2016: MSphere
https://www.readbyqxmd.com/read/27941174/nocturnal-levels-of-chemerin-and-progranulin-in-adolescents-influence-of-sex-body-mass-index-glucose-metabolism-and-sleep
#8
Johann Daxer, Theresa Herttrich, Ying Y Zhao, Mandy Vogel, Andreas Hiemisch, Kathrin Scheuermann, Antje Körner, Jürgen Kratzsch, Wieland Kiess, Mirja Quante
BACKGROUND: Adipokines have been implicated in obesity, insulin resistance and sleep regulation. However, the role of chemerin and progranulin, two recently described adipokines, in the context of sleep remains unclear. The aim of this study was to compare nocturnal serum chemerin and progranulin levels between overweight/obese and normal-weight adolescents and to assess variations by sex, across different sleep stages and in relation to glucose metabolism. METHODS: The study sample included 34 overweight/obese and 32 normal-weight adolescents from secondary schools and the Leipzig Research Center for Civilization Diseases (LIFE) Child study cohort...
January 1, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27932075/non-enzymatic-oxidized-metabolite-of-dha-4-rs-4-f4t-neuroprostane-protects-the-heart-against-reperfusion-injury
#9
Jérôme Roy, Jérémy Fauconnier, Camille Oger, Charlotte Farah, Claire Angebault-Prouteau, Jérôme Thireau, Patrice Bideaux, Valérie Scheuermann, Valérie Bultel-Poncé, Marie Demion, Jean-Marie Galano, Thierry Durand, Jetty Chung-Yung Lee, Jean-Yves Le Guennec
Acute myocardial infarction leads to an increase in oxidative stress and lipid peroxidation. 4(RS)-4-F4t-Neuroprostane (4-F4t-NeuroP) is a mediator produced by non-enzymatic free radical peroxidation of the cardioprotective polyunsaturated fatty acid, docosahexaenoic acid (DHA). In this study, we investigated whether intra-cardiac delivery of 4-F4t-NeuroP (0.03mg/kg) prior to occlusion (ischemia) prevents and protects rat myocardium from reperfusion damages. Using a rat model of ischemic-reperfusion (I/R), we showed that intra-cardiac infusion of 4-F4t-NeuroP significantly decreased infarct size following reperfusion (-27%) and also reduced ventricular arrhythmia score considerably during reperfusion (-41%)...
January 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27928471/radiological-imaging-findings-of-scheuermann-disease
#10
Erkan Gokce, Murat Beyhan
AIM: To find accompanying anomalies of typical and atypical Scheuermann's disease (SD) is reported in the present study. METHODS: Study included 20 patients (16 men and 4 women) who had radiological imaging radiography, magnetic resonance imaging (MRI) and computed tomography, if available, due to back pain, curved back and low back pain in November 2011-February 2016 period. Patients were categorized into typical and atypical patterns based on the region involved...
November 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27904931/-arthroscopic-tenodesis-or-tenotomy-of-the-long-head-of-the-biceps-tendon-in-preselected-patients-does-it-make-a%C3%A2-difference
#11
M Kerschbaum, N Maziak, M Scheuermann, M Scheibel
BACKGROUND: Are there clinical, cosmetic and/or structural differences between tenotomy and tenodesis of the long head of the biceps tendon (LHB) in patients selected according to commonly used indication criteria? MATERIAL AND METHODS: A total of 85 patients were included in this study. An LHB tenodesis (LHB-TD) was performed in 49 patients and a tenotomy (LHB-TT) in 36 patients. In addition to a standardized examination, the age and gender adjusted Constant score (aCS), the LHB score and the subjective shoulder value (SSV) were assessed...
November 30, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27897007/production-of-a-preliminary-quality-control-pipeline-for-single-nuclei-rna-seq-and-its-application-in-the-analysis-of-cell-type-diversity-of-post-mortem-human-brain-neocortex
#12
Brian Aevermann, Jamison McCorrison, Pratap Venepally, Rebecca Hodge, Trygve Bakken, Jeremy Miller, Mark Novotny, Danny N Tran, Francisco Diezfuertes, Lena Christiansen, Fan Zhang, Frank Steemers, Roger S Lasken, E D Lein, Nicholas Schork, Richard H Scheuermann
Next generation sequencing of the RNA content of single cells or single nuclei (sc/nRNA-seq) has become a powerful approach to understand the cellular complexity and diversity of multicellular organisms and environmental ecosystems. However, the fact that the procedure begins with a relatively small amount of starting material, thereby pushing the limits of the laboratory procedures required, dictates that careful approaches for sample quality control (QC) are essential to reduce the impact of technical noise and sample bias in downstream analysis applications...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27858694/goniometric-evaluation-of-the-spinal-sagittal-curves-in-children-and-adolescents-a-reliability-study
#13
Aristide Gravina, Claudio Ferraro, Patrizia Poli, Michele Barazzuol, Alessandra Del Felice, Stefano Masiero
BACKGROUND: Gold standard for spine deformities assessment is X rays, but the procedure bears a risk of exposure. OBJECTIVE: To investigate intra-rater and inter-rater reliability of a pocket compass needle goniometer (IncliMed®, University of Padua) to non-invasively evaluate spine curves in children and adolescents. METHODS: Prospective reliability study in a paediatric population (mean age 12.5 years ± 2.5). Children with spine deformities (Scheuermann's or postural kyphosis, idiopathic scoliosis) and healthy controls were included...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27815125/meeting-report-29th-international-conference-on-antiviral-research-in-la-jolla-ca-usa
#14
REVIEW
R Anthony Vere Hodge
The 29th International Conference on Antiviral Research (ICAR) was held in La Jolla, CA, USA from April 17 to 21, 2016. This report opens with a tribute to the late Chris McGuigan, a Past-President of ISAR, then continues with summaries of the principal invited lectures. Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holý Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV...
January 2017: Antiviral Research
https://www.readbyqxmd.com/read/27785478/outcome-of-intensive-outpatient-rehabilitation-and-bracing-in-an-adult-patient-with-scheuermann-s-disease-evaluated-by-radiologic-imaging-a-case-report
#15
Hagit Berdishevsky
BACKGROUND: No studies examine the efficacy of intensive specific physical therapy (PT) exercises along with brace for the adult with Scheuermann's kyphosis (SK). The aim of this study was to examine the effects of intensive PT based on the Barcelona Scoliosis Physical Therapy School (BSPTS) and SpinoMed brace on a 76-year-old female with SK. CASE DESCRIPTION: A 76-year-old female, diagnosed with SK as an adolescent, presented in October 2014 with thoracic hyperkyphosis T1 to T12 Cobb angle of 85° and lumbar hyper lordosis L1 to L5 Cobb angle of 70°...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27785472/conservative-treatment-in-scheuermann-s-kyphosis-comparison-between-lateral-curve-and-variation-of-the-vertebral-geometry
#16
Angelo G Aulisa, Francesco Falciglia, Marco Giordano, Giuseppe Mastantuoni, Andrea Poscia, Vincenzo Guzzanti
BACKGROUND: Conservative treatment in the Scheuermann's kyphosis obtain, during skeletal growth, remodelling of the deformed vertebras. In a previous paper on Scheuermann's kyphosis, we have studied the geometry variations of all vertebrae included in the curve, before and after the treatment. The purpose of this study was to confirm the effectiveness of conservative treatment in Scheuermann's kyphosis and was to evaluate and compare the variation of the vertebral geometry with the curve trend in Cobb degrees, before and after conservative treatment...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27785469/bracing-for-adolescent-idiopathic-scoliosis-ais-and-scheuermann-kyphosis-the-issue-of-overtreatment-in-greece
#17
Nikos S Karavidas
BACKGROUND: Most recent publications have provided evidence for brace treatment in spinal deformities. The purpose of this study was to evaluate the rate of overtreatment for AIS and Kyphosis in Greece, according to the Society on Scoliosis Orthopedic Rehabilitation Treatment (SOSORT) and the Scoliosis Research Society (SRS) guidelines for brace treatment. To date, this is the first study to investigate overtreatment percentage in a group of patients with spinal deformities. METHODS: Cross-sectional study design and data analysis were performed in a group of patients that received treatment in a private clinic, in 2014...
2016: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/27766961/vdjml-a-file-format-with-tools-for-capturing-the-results-of-inferring-immune-receptor-rearrangements
#18
Inimary T Toby, Mikhail K Levin, Edward A Salinas, Scott Christley, Sanchita Bhattacharya, Felix Breden, Adam Buntzman, Brian Corrie, John Fonner, Namita T Gupta, Uri Hershberg, Nishanth Marthandan, Aaron Rosenfeld, William Rounds, Florian Rubelt, Walter Scarborough, Jamie K Scott, Mohamed Uduman, Jason A Vander Heiden, Richard H Scheuermann, Nancy Monson, Steven H Kleinstein, Lindsay G Cowell
BACKGROUND: The genes that produce antibodies and the immune receptors expressed on lymphocytes are not germline encoded; rather, they are somatically generated in each developing lymphocyte by a process called V(D)J recombination, which assembles specific, independent gene segments into mature composite genes. The full set of composite genes in an individual at a single point in time is referred to as the immune repertoire. V(D)J recombination is the distinguishing feature of adaptive immunity and enables effective immune responses against an essentially infinite array of antigens...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27765710/rates-and-risk-factors-associated-with-unplanned-hospital-readmission-after-fusion-for-p%C3%A3-diatric-spinal-deformity
#19
Erika Roddy, Mohammad Diab
BACKGROUND CONTEXT: Short-term readmission rates are becoming widely utilized as a quality and performance metrics for hospitals. Data on unplanned short-term readmission after spine fusion for deformity in pædiatric patients is limited. PURPOSE: To characterize the rate and risk factors for short-term readmission after spine fusion for deformity in pædiatric patients. STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: State In-Patient Databases from NY, UT, NE, FL, NC (years 2006-2010) and CA (years 2006-2011)...
October 17, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27688827/antioxidant-and-vasodilator-activity-of-ugni-molinae-turcz-murtilla-and-its-modulatory-mechanism-in-hypotensive-response
#20
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
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