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Inimary T Toby, Mikhail K Levin, Edward A Salinas, Scott Christley, Sanchita Bhattacharya, Felix Breden, Adam Buntzman, Brian Corrie, John Fonner, Namita T Gupta, Uri Hershberg, Nishanth Marthandan, Aaron Rosenfeld, William Rounds, Florian Rubelt, Walter Scarborough, Jamie K Scott, Mohamed Uduman, Jason A Vander Heiden, Richard H Scheuermann, Nancy Monson, Steven H Kleinstein, Lindsay G Cowell
BACKGROUND: The genes that produce antibodies and the immune receptors expressed on lymphocytes are not germline encoded; rather, they are somatically generated in each developing lymphocyte by a process called V(D)J recombination, which assembles specific, independent gene segments into mature composite genes. The full set of composite genes in an individual at a single point in time is referred to as the immune repertoire. V(D)J recombination is the distinguishing feature of adaptive immunity and enables effective immune responses against an essentially infinite array of antigens...
October 6, 2016: BMC Bioinformatics
Erika Roddy, Mohammad Diab
BACKGROUND CONTEXT: Short-term readmission rates are becoming widely utilized as a quality and performance metrics for hospitals. Data on unplanned short-term readmission after spine fusion for deformity in pædiatric patients is limited. PURPOSE: To characterize the rate and risk factors for short-term readmission after spine fusion for deformity in pædiatric patients. STUDY DESIGN: Retrospective cohort study PATIENT SAMPLE: State In-Patient Databases from NY, UT, NE, FL, NC (years 2006-2010) and CA (years 2006-2011)...
October 17, 2016: Spine Journal: Official Journal of the North American Spine Society
Ignacio Jofré, Cesar Pezoa, Magdalena Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin-3-β-D-glucoside, Myricetin, Quercetin, and Kaempferol were identified...
2016: Oxidative Medicine and Cellular Longevity
Yun Zhang, Brian D Aevermann, Tavis K Anderson, David F Burke, Gwenaelle Dauphin, Zhiping Gu, Sherry He, Sanjeev Kumar, Christopher N Larsen, Alexandra J Lee, Xiaomei Li, Catherine Macken, Colin Mahaffey, Brett E Pickett, Brian Reardon, Thomas Smith, Lucy Stewart, Christian Suloway, Guangyu Sun, Lei Tong, Amy L Vincent, Bryan Walters, Sam Zaremba, Hongtao Zhao, Liwei Zhou, Christian Zmasek, Edward B Klem, Richard H Scheuermann
The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support...
September 26, 2016: Nucleic Acids Research
Kimber P Richter, Babalola Faseru, Theresa I Shireman, Laura M Mussulman, Niaman Nazir, Terry Bush, Taneisha S Scheuermann, Kristopher J Preacher, Beatriz H Carlini, Brooke Magnusson, Edward F Ellerbeck, Carol Cramer, David J Cook, Mary J Martell
INTRODUCTION: Few hospitals treat patients' tobacco dependence. To be effective, hospital-initiated cessation interventions must provide at least 1 month of supportive contact post-discharge. STUDY DESIGN: Individually randomized clinical trial. Recruitment commenced July 2011; analyses were conducted October 2014-June 2015. SETTING/PARTICIPANTS: The study was conducted in two large Midwestern hospitals. Participants included smokers who were aged ≥18 years, planned to stay quit after discharge, and spoke English or Spanish...
October 2016: American Journal of Preventive Medicine
Olcay Guler, Turgut Akgul, Murat Korkmaz, Caner Gunerbuyuk, Kerim Sariyilmaz, Fatih Dikici, Ufuk Talu
PURPOSE: To comparatively evaluate the biomechanical alterations those occur in the sagittal plane of sacropelvic junction in angular kyphosis (AK) and Scheuermann kyphosis (SK) patients after surgery. METHODS: The spine radiographs of 52 patients operated for short-segment AK (n = 20) or SK (n = 32) were studied. Main outcome measures were sacral slope, pelvic incidence, pelvic tilt, lumbar lordosis, and thoracic kyphosis angles. RESULTS: In AK group, local and thoracic kyphosis angles, as well as lumbar lordosis angle, showed statistically significant reduction with surgery...
September 3, 2016: European Spine Journal
Yanfeng Ji, Fei Hui, Yuanyuan Shi, Vanessa Iglesias, David Lewis, Jiebin Niu, Shibing Long, Ming Liu, Alexander Hofer, Werner Frammelsberger, Guenther Benstetter, Andrew Scheuermann, Paul C McIntyre, Mario Lanza
The conductive atomic force microscope (CAFM) has become an essential tool for the nanoscale electronic characterization of many materials and devices. When studying photoactive samples, the laser used by the CAFM to detect the deflection of the cantilever can generate photocurrents that perturb the current signals collected, leading to unreliable characterization. In metal-coated semiconductor samples, this problem is further aggravated, and large currents above the nanometer range can be observed even without the application of any bias...
August 2016: Review of Scientific Instruments
Jakob D Lauver, Trent E Cayot, Barry W Scheuermann
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Moritz Schreier, Julian Tristan Schwartze, Kathrin Landgraf, Kathrin Scheuermann, Sandra Erbs, Gunda Herberth, J Andrew Pospisilik, Jürgen Kratzsch, Wieland Kiess, Antje Körner
CONTEXT: Osteopontin (OPN) has been proposed to predict adverse cardiac events in adult type 2 diabetes patients. OBJECTIVE: We investigated potential associations of circulating OPN and OPN expression in adipose tissue (AT) with obesity and early metabolic and cardiovascular dysfunction in children. Furthermore, we assessed the functional relevance of OPN on primary human endothelial cells. DESIGN: Serum OPN was determined in healthy lean (n=65) and obese (n=100) children by ELISA...
August 29, 2016: Journal of Clinical Endocrinology and Metabolism
Heiko Tzschätzsch, Manh Nguyen Trong, Tobias Scheuermann, Selcan Ipek-Ugay, Thomas Fischer, Michael Schultz, Jürgen Braun, Ingolf Sack
Measurement of shear wave speed of the liver and spleen by elastography is an established diagnostic procedure for the detection of hepatic fibrosis, portal hypertension and esophageal varices. However, current elastography systems are limited by the size and penetration depth of elastographic windows. In this study, 2D time-harmonic elastography is proposed for generating full field-of-view shear wave speed maps in great depth. Two-dimensional time-harmonic elastography uses external harmonic stimulation at multiple frequencies to create compound shear wave speed maps...
November 2016: Ultrasound in Medicine & Biology
Martina Roos, Ugo Pradère, Richard P Ngondo, Alok Behera, Sara Allegrini, Gianluca Civenni, Julian A Zagalak, Jean-Rémy Marchand, Mirjam Menzi, Harry Towbin, Jörg Scheuermann, Dario Neri, Amedeo Caflisch, Carlo V Catapano, Constance Ciaudo, Jonathan Hall
New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor suppressor is blocked by an RNA binding protein (RBP) Lin28, which docks onto a conserved sequence in let-7 precursor RNA molecules and prevents their maturation. Thus, the Lin28/let-7 interaction might be an attractive drug target, if not for the well-known difficulty in targeting RNA-protein interactions with drugs. Here, we describe a protein/RNA FRET assay using a GFP-Lin28 donor and a black-hole quencher (BHQ)-labeled let-7 acceptor, a fluorescent protein/quencher combination which is rarely used in screening despite favorable spectral properties...
October 21, 2016: ACS Chemical Biology
Olivia L Hendricks, Andrew G Scheuermann, Michael Schmidt, Paul K Hurley, Paul C McIntyre, Christopher E D Chidsey
We synthesized nanoscale TiO2-RuO2 alloys by atomic layer deposition (ALD) that possess a high work function and are highly conductive. As such, they function as good Schottky contacts to extract photogenerated holes from n-type silicon while simultaneously interfacing with water oxidation catalysts. The ratio of TiO2 to RuO2 can be precisely controlled by the number of ALD cycles for each precursor. Increasing the composition above 16% Ru sets the electronic conductivity and the metal work function. No significant Ohmic loss for hole transport is measured as film thickness increases from 3 to 45 nm for alloy compositions ≥ 16% Ru...
September 14, 2016: ACS Applied Materials & Interfaces
Seth S Molloy, Faiz U Ahmad, Griffin R Baum, Barth A Green, Nathan H Lebwohl
OBJECTIVE: To report the successful correction of a severe, fixed kyphotic deformity utilizing a combination posterior lumbar interbody fusion (PLIF) and Ponte osteotomy at the site of acute kyphosis. SUMMARY OF BACKGROUND DATA: There have been no reports on the experience and surgical strategy of combined one-level focal PLIF and Ponte osteotomy for fixed severe kyphotic deformity. Typically, these corrections would need a pedicle subtraction osteotomy or a vertebrectomy...
2016: Curēus
Stefan Matecki, Haikel Dridi, Boris Jung, Nathalie Saint, Steven R Reiken, Valérie Scheuermann, Ségolène Mrozek, Gaetano Santulli, Alisa Umanskaya, Basil J Petrof, Samir Jaber, Andrew R Marks, Alain Lacampagne
Ventilator-induced diaphragmatic dysfunction (VIDD) refers to the diaphragm muscle weakness that occurs following prolonged controlled mechanical ventilation (MV). The presence of VIDD impedes recovery from respiratory failure. However, the pathophysiological mechanisms accounting for VIDD are still not fully understood. Here, we show in human subjects and a mouse model of VIDD that MV is associated with rapid remodeling of the sarcoplasmic reticulum (SR) Ca(2+) release channel/ryanodine receptor (RyR1) in the diaphragm...
August 9, 2016: Proceedings of the National Academy of Sciences of the United States of America
Pei Zhang, S A Galindo-Torres, Hongwu Tang, Guangqiu Jin, A Scheuermann, Ling Li
We investigated the settling dynamics of irregularly shaped particles in a still fluid under a wide range of conditions with Reynolds numbers Re varying between 1 and 2000, sphericity ϕ and circularity c both greater than 0.5, and Corey shape factor (CSF) less than 1. To simulate the particle settling process, a modified lattice Boltzmann model combined with a turbulence module was adopted. This model was first validated using experimental data for particles of spherical and cubic shapes. For irregularly shaped particles, two different types of settling behaviors were observed prior to particles reaching a steady state: accelerating and accelerating-decelerating, which could be distinguished by a critical CSF value of approximately 0...
June 2016: Physical Review. E
Cao Yun, Cai Liang Shen
PURPOSE: Anterior release for Scheuermann's disease was considered an important technique for decades. However, posterior-only surgery for Scheuermann's disease has shown a promising potential to manage this deformity, as well. Correction loss could happen post-operatively, especially when posterior-only surgery is performed in the early days. Therefore, a dispute regarding anterior release for Scheuermann's disease exists. METHODS: We performed a systematic review of studies, reporting the outcomes of anterior release and posterior fusion surgery (AP group) or posterior-only surgery (PO group) for Scheuermann's disease...
July 6, 2016: European Spine Journal
G Valdes, R Scheuermann, C Y Hung, A Olszanski, M Bellerive, T D Solberg
PURPOSE: It is common practice to perform patient-specific pretreatment verifications to the clinical delivery of IMRT. This process can be time-consuming and not altogether instructive due to the myriad sources that may produce a failing result. The purpose of this study was to develop an algorithm capable of predicting IMRT QA passing rates a priori. METHODS: From all treatment, 498 IMRT plans sites were planned in eclipse version 11 and delivered using a dynamic sliding window technique on Clinac iX or TrueBeam Linacs...
July 2016: Medical Physics
Aaron P Shaw, Shinichiro Sugiura, Hong Xie, Carol Angel, Andrew Cotton, Seyed Sahand Banisadr, Xin Wang, Barry W Scheuermann, David L Weldy
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Erin C Garmyn, Barry W Scheuermann
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Andrew G Scheuermann, Paul C McIntyre
A fundamental challenge in developing photoelectrochemical cells for the renewable production of solar chemicals and fuels is the simultaneous requirement of efficient light absorption and robust stability under corrosive conditions. Schemes for corrosion protection of semiconductor photoelectrodes such as silicon using deposited layers were proposed and attempted for several decades, but increased operational lifetimes were either insufficient or the resulting penalties for device efficiency were prohibitive...
July 21, 2016: Journal of Physical Chemistry Letters
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