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Gabrielle Martel, Charles-André Couture, Guillaume Gilbert, Stéphane Bancelin, Hélène Richard, Thomas Moser, Sabrina Kiss, François Légaré, Sheila Laverty
Osteochondrosis is an ischemic chondronecrosis of epiphyseal growth cartilage that results in focal failure of endochondral ossification and osteochondritis dissecans at specific sites in the epiphyses of humans and animals, including horses. The upstream events leading to the focal ischemia remain unknown. The epiphyseal growth cartilage matrix is composed of proteoglycan and collagen macromolecules and encases its vascular tree in canals. The matrix undergoes major dynamic changes in early life that could weaken it biomechanically and predispose it to focal trauma and vascular failure...
October 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Leon Prozesky, Johan Neser, Heinz Meissner, Kenneth Botha, Lubbe Jacobs, Craig Shepstone, Hannes Viljoen, Hinner Köster, Chris De Brouwer, Jan Van Zyl, Gerjan Van der Veen
The north-western part of South Africa, in particular, is well known for mineral imbalances. Aphosphorosis, resulting in rickets and osteomalacia, received a lot of attention at the turn of the nineteenth century (1882-1912). This was followed in 1997 by research on Vryburg hepatosis, another area-specific mineral imbalance-related disease in young calves reared on manganese-rich soil derived from the weathering of dolomitic (carbonate) rock formations. In 1982, a totally new syndrome (osteochondrosis) manifested in, amongst others, areas in South Africa where aphosphorosis was rife...
2016: Onderstepoort Journal of Veterinary Research
L B Borst, M M Suyemoto, A H Sarsour, M C Harris, M P Martin, J D Strickland, E O Oviedo, H J Barnes
Enterococcal spondylitis (ES) is a disease of commercial broiler chickens, with a worldwide distribution. Symmetrical hind limb paralysis typical of ES results from infection of the free thoracic vertebra (FTV) by pathogenic strains of Enterococcus cecorum To determine the pathogenesis of ES, birds with natural and experimental ES were studied over time. In natural disease, case birds (n = 150) from an affected farm and control birds (n = 100) from an unaffected farm were evaluated at weeks 1-6. In control birds, intestinal colonization by E...
August 10, 2016: Veterinary Pathology
A L Nadkevich, L S Babinets
The expediency of application homeosyniatry by preparations of Traumel S and Placenta Compositum after the offered chart in relation to a complex with classic acupuncture and in relation to the group of the generally accepted treatment has been proved in complex treatment patients with reflex syndromes of lumbar osteochondrosis. A similar conclusion was done after the statistically reliable (P < 0.05) dynamics of parameters of endogenous intoxication, liperoxydation and antioxydant systems of the protection (by the level of katalase, superoxyddismutase, SH-groups, ceruloplasmine)...
October 2015: Likars'ka Sprava
Sarah Nemanic, Britton K Nixon, Wendy Baltzer
OBJECTIVE: Identify radiographic risk factors for development of elbow dysplasia in giant breed dogs less than one year of age. METHODS: Twenty-five giant breed puppies (Bernese Mountain dogs, English Mastiff, and Newfoundland) were studied. Both elbows of each dog were radiographed monthly from two to six months of age, then every other month until radial and ulnar physeal closure, followed two months later by bilateral elbow computed tomography. Radiographic parameters measured included the presence or absence of a separate centre of ossification of the anconeal process (SCOAP), medial coronoid disease (MCD), ununited anconeal process, humeral osteochondrosis, elbow incongruity, as well as the length of the radius and ulna, radius-to-ulna ratio, and date of closure of the radial and ulnar physes...
September 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
C Kajetanek, M Thaunat, T Guimaraes, O Carnesecchi, M Daggett, B Sonnery-Cottet
Sinding-Larsen-Johansson (SLJ) syndrome is a type of osteochondrosis of the distal pole of the patella most often caused by repeated microtrauma. Here, we describe the case of a professional athlete with painful SLJ syndrome treated arthroscopically. A 29-year-old male professional handball player presented with anterior knee pain that persisted after 4 months of an eccentric rehabilitation protocol and platelet-rich plasma injections. Despite this conservative treatment, the patient could not participate in his sport...
September 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
J Russell, O Matika, T Russell, R J M Reardon
BACKGROUND: Osteochondrosis is considered multi-factorial in origin, with factors such as nutrition, conformation, body size, trauma and genetics thought to contribute to its pathogenesis. Few studies have investigated the effect of genetic variability of osteochondrosis in Thoroughbreds. OBJECTIVES: Describe the prevalence and genetic variability of a subset of osteochondrosis lesions in a group of Thoroughbred yearlings. STUDY DESIGN: Retrospective cohort study...
July 23, 2016: Equine Veterinary Journal
G A Sorokin
There are reported data of the analysis of parameters of the general morbidity (hypertension, chronic diseases, organs of respiratory and digestive system, adiposity, vertebral osteochondrosis) in dependence on age and work experience of dockers-mechanizators in seaport at various working conditions. Morbidity rate indices were calculated on results of the profound medical examination at annual periodic surveys of workers. There were analyzed ecological and ergonomic indices of working conditions, including an estimation of physiological intensity of the work...
2016: Gigiena i Sanitariia
N Sevane, S Dunner, A Boado, J Cañon
Equine osteochondrosis (OC) is a frequent developmental orthopaedic disease with high economic impact on the equine industry and may lead to premature retirement of the animal as a result of chronic pain and lameness. The genetic background of OC includes different genes affecting several locations; however, these genetic associations have been tested in only one or few populations, lacking the validation in others. The aim of this study was to identify the genetic determinants of OC in the Spanish Purebred horse breed...
October 2016: Animal Genetics
Johnnie Faircloth, Jennifer J Mitchell, David S Edwards
INTRODUCTION: Freiberg infraction is a relatively rare osteochondrosis of the metatarsal head. The etiology of Freiberg infraction is poorly understood but likely involves factors such as, repetitive trauma and vascular compromise. When discovered early, Freiberg infraction can be cured with conservative measures but late presentations require surgical intervention. We present a case of stage V Freiberg infraction in a Division I collegiate tennis player that responded to conservative treatment...
July 2015: Journal of Orthopaedic Case Reports
Ferenc Tóth, Frédéric H David, Elizabeth LaFond, Luning Wang, Jutta M Ellermann, Cathy S Carlson
In vivo visualization of subclinical osteochondrosis (OC) lesions, characterized by necrosis of epiphyseal growth cartilage, is necessary to clarify the pathogenesis of this disease. Hence, our objectives were to demonstrate induced necrosis of the epiphyseal cartilage in vivo using MRI and to monitor progression or resolution of resulting lesions. We also aimed to improve the goat model of OC by introducing controlled exercise. Vascular supply to the epiphyseal cartilage was surgically interrupted in four 5-day-old goats to induce ischemic cartilage necrosis in a medial femoral condyle...
June 10, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Alessandra Colombini, Marco Brayda-Bruno, Giovanni Lombardi, Samantha Jennifer Croiset, Cristina Ceriani, Cinzia Buligan, Mattia Barbina, Giuseppe Banfi, Sabina Cauci
Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) are commonly studied in several pathologies. We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an Italian cohort of 266 patients with lumbar spine disorders assessed by Magnetic Resonance Imaging and 252 asymptomatic controls. The exposure to putative risk factors was evaluated by a questionnaire. Polymorphisms were detected by PCR-RFLP and TaqMan® SNP Genotyping Assay...
2016: PloS One
Wenko Smolka, Karl Sotlar, Max Weiss, Ullrich Müller-Lisse
A case of a 71-year-old female patient with osteochondrosis dissecans of the right temporomandibular joint is presented. Osteochondrosis dissecans usually occurs at the weight-bearing convex cartilage in all larger joints. It is rarely found in the temporomandibular joint and usually shows one or two loose bodies dislodged from defects which are present on the condylar head. Because of multiple loose bodies and a defect on the temporomandibular fossa, the case presented here is very uncommon.
September 2016: Oral and Maxillofacial Surgery
Luis Mendoza, Jean-Philippe Lejeune, Isabelle Caudron, Johann Detilleux, Charlotte Sandersen, Brigitte Deliège, Didier Serteyn
Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of osteochondral fragments in the articulation, fissures or subchondral bone cysts in the growth cartilage. Occurrence of osteochondrosis is influenced by a complex interaction of different factors. Among these, the effect of the housing and the feeding of the foals during their first months of life, have been described as risk factors for the development of osteochondrosis...
May 1, 2016: Preventive Veterinary Medicine
Martin Dostal, Denis Laurent Kaech
Background Anterior cervical diskectomy (ACD) is an established therapy for degenerative cervical radiculopathy and myelopathy. Controversy remains regarding the dynamic or rigid stabilization of the segment. Methods We studied our first 31 patients treated with ACD plus the Dynamic Cervical Implant (DCI) as an alternative to fusion or to arthroplasty, treated between February 2009 and 2011. Radiologic data were collected before and 12 months after surgery. Clinical results were documented 12 months after surgery...
March 29, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Christian P Bertholle, Ellen Meijer, Willem Back, Arjan Stegeman, P René van Weeren, Arie van Nes
BACKGROUND: In today's porcine industry, lameness has a major welfare and economic impact, and is often caused by osteochondrosis (OC). The etiological factors of the disease have been studied in depth, however, to this day, little is known about the natural course of the disorder and how it can be detected at an early stage in pigs. The aim of this pilot study was to assess the potential of three non-invasive techniques for the detection and monitoring of early OC processes in piglets...
2016: BMC Veterinary Research
Christopher Basu, Alexander L Stoll, Jonathon Dixon, Fieke Marije Molenaar, Edmund Flach, Ken C Smith
An adult male reticulated giraffe (Giraffa camelopardalis reticulata) was presented for postmortem examination. During radiologic examination of the hindlimbs, osseous cyst-like lesions were detected in both medial femoral condyles. These lesions were subsequently examined macroscopically and histologically. The gross appearance suggested a diagnosis of bilateral osteochondrosis that was confirmed with histopathologic examination. This finding has not previously been reported in giraffes. Macroscopic visualization of the major limb joints, including the femorotibial joints, is therefore encouraged in future postmortem examinations of giraffes (Giraffa camelopardalis), and further assessment of clinical significance is required...
March 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Emin Özkul, Mehmet Gem, Celil Alemdar, Hüseyin Arslan, Ferit Boğatekin, Bülent Kişin
BACKGROUND: Freiberg's disease is an osteochondrosis most commonly seen in adolescent women and characterized by pain, swelling and motion restriction in the second metatarsal. The early stages of this disease can be managed with semirigid orthoses, metatarsal bars and short leg walking cast. Number of operative methods are suggested which can be used depending on the pathophysiology of the disease, including abnormal biomechanics, joint congruence and degenerative process. We evaluated the outcomes of the patients with Freiberg's disease who were treated with dorsal closing-wedge osteotomy and resection of the metatarsal head...
January 2016: Indian Journal of Orthopaedics
Erik Hohmann, Kevin Tetsworth
BACKGROUND: The purpose of this study was to review the clinical results of irradiated fresh frozen osteochondral allografts for large osteochondral defects of the knee using the Mega-OATS technique. METHODS: Nine patients with a mean age of 32.1±6.6 (18 to 44) underwent Mega-OATS transplantation with irradiated (2.5Mrad), fresh frozen distal femur allograft. Three patients also underwent ACL-reconstruction; one patient a high tibial osteotomy. The underlying indication was osteochondrosis dissecans in four and trauma in five patients...
June 2016: Knee
Astrid Ellen Grams, Rafael Rehwald, Alexander Bartsch, Sarah Honold, Christian Franz Freyschlag, Michael Knoflach, Elke Ruth Gizewski, Bernhard Glodny
BACKGROUND: Spondylosis leads to an overestimation of bone mineral density (BMD) with dual-energy x-ray absorptiometry (DXA) but not with quantitative computed tomography (QCT). The correlation between degenerative changes of the spine and QCT-BMD was therefore investigated for the first time. METHODS: One hundred thirty-four patients (66 female and 68 male) with a mean age of 49.0 ± 14.6 years (range: 19-88 years) who received a CT scan and QCT-BMD measurements of spine and hip were evaluated retrospectively...
2016: BMC Medical Imaging
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