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https://www.readbyqxmd.com/read/28230573/global-sagittal-imbalance-due-to-change-in-pelvic-incidence-after-traumatic-spinopelvic-dissociation
#1
Han-Dong Lee, Chang-Hoon Jeon, Nam-Su Chung, Suk-Hyeong Won
OBJECTIVES: Traumatic spinopelvic dissociation separates the spinal column from the pelvis, which usually creates lumbosacral kyphosis. We aimed to examine how the spinopelvic profiles changes after traumatic spinopelvic dissociation, and which are the relevant factors for the sagittal imbalance of the spine. DESIGN: Retrospective analysis. SETTING: Level I trauma center PATIENTS:: Thirty-nine consecutive patients who were diagnosed with traumatic spinopelvic dissociation and had a minimum 2-year radiological follow-up were included...
February 20, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28230213/knock-in-human-fgfr3-achondroplasia-mutation-as-a-mouse-model-for-human-skeletal-dysplasia
#2
Yi-Ching Lee, I-Wen Song, Ya-Ju Pai, Sheng-De Chen, Yuan-Tsong Chen
Achondroplasia (ACH), the most common genetic dwarfism in human, is caused by a gain-of function mutation in fibroblast growth factor receptor 3 (FGFR3). Currently, there is no effective treatment for ACH. The development of an appropriate human-relevant model is important for testing potential therapeutic interventions before human clinical trials. Here, we have generated an ACH mouse model in which the endogenous mouse Fgfr3 gene was replaced with human FGFR3(G380R) (FGFR3(ACH)) cDNA, the most common mutation in human ACH...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28225365/magnitude-location-and-factors-related-to-regional-and-global-sagittal-alignment-change-in-long-adult-deformity-constructs-report-of-183-patients-with-2-year-follow-up
#3
Alexander A Theologis, Michael Safaee, Justin K Scheer, Virginie Lafage, Rick Hostin, Robert A Hart, Eric O Klineberg, Themistocles S Protopsaltis, Vedat Deviren, Douglas C Burton, Daniel M Sciubba, Khaled Kebaish, Shay Bess, Christopher I Shaffrey, Frank Schwab, Justin S Smith, Christopher P Ames
STUDY DESIGN: This is a retrospective review of a prospective multicenter adult spinal deformity (ASD) database. OBJECTIVE: To quantify the location and magnitude of sagittal alignment changes within instrumented and noninstrumented spinal segments and to investigate the factors associated with these changes after surgery for ASD. SUMMARY OF BACKGROUND DATA: Spinal realignment is one of the major goals in ASD surgery and changes in the alignment are common following surgical correction...
February 20, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28223250/dorsal-cervical-spinal-cord-herniation-precipitated-by-kyphosis-deformity-correction-for-spinal-cord-tethering
#4
Robert S Heller, Steven W Hwang, Ron I Riesenburger
INTRODUCTION: Cervical spinal cord herniation (SCH) is a rare clinical entity. Reported following prior intradural surgery or surgery complicated by durotomy, patients return several months to years later with symptoms of worsening myelopathy. Herein is presented a case of a 51-year old female with SCH in the cervical spine following kyphosis deformity correction CASE DESCRIPTION: A 51-year old female presented to the Neurosurgery clinic with worsening cervical myelopathy due to cervical spinal cord tethering and adhesions from prior intradural surgery for Chiari malformation...
February 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28222402/impact-of-anchor-type-on-porcine-lumbar-biomechanics-finite-element-modelling-and-in-vitro-validation
#5
Martin Brummund, Vladimir Brailovski, Yvan Petit, Yann Facchinello, Jean-Marc Mac-Thiong
BACKGROUND: Rigid posterior implants used for spinal stabilization can be anchored to the vertebrae using pedicle screws or screws combined with transverse process hooks. In the present study, a finite element model of a porcine lumbar spine instrumented with screws and hooks is presented and validated. METHODS: The porcine lumbar spine model was validated using in-vitro measurements on six porcine specimens. Validation metrics included intervertebral rotations (L1 to L6) and nucleus pressure in the topmost cranial instrumented disc...
February 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28220607/neurological-and-spinal-manifestations-of-the-ehlers-danlos-syndromes
#6
Fraser C Henderson, Claudiu Austin, Edward Benzel, Paolo Bolognese, Richard Ellenbogen, Clair A Francomano, Candace Ireton, Petra Klinge, Myles Koby, Donlin Long, Sunil Patel, Eric L Singman, Nicol C Voermans
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression...
February 21, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28219364/the-relationship-between-changes-of-cervical-sagittal-alignment-after-anterior-cervical-discectomy-and-fusion-and-spino-pelvic-sagittal-alignment-under-roussouly-classification-a-four-year-follow-up-study
#7
Dong-Ning Huang, Miao Yu, Nan-Fang Xu, Mai Li, Shao-Bo Wang, Yu Sun, Liang Jiang, Feng Wei, Xiao-Guang Liu, Zhong-Jun Liu
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is widely used in the treatment of cervical degenerative disease; however, the variation of cervical sagittal alignment changes after ACDF has been rarely explored. The purpose of this study is to determine the relationship between changes of cervical sagittal alignment after ACDF and spino-pelvic sagittal alignment under Roussouly classification. METHODS: A cohort of 133 Chinese cervical spondylotic patients who received ACDF from 2011 to 2012 was recruited...
February 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28216750/early-results-of-thoraco-lumbar-burst-fracture-treatment-using-selective-corpectomy-and-rectangular-cage-reconstruction
#8
Bowei Liang, Guofeng Huang, Luobing Ding, Liangqi Kang, Mo Sha, Zhenqi Ding
BACKGROUND: Subsidence and late fusion are commonly observed in anterior subtotal corpectomy and reconstruction for treating thoracolumbar burst fractures. The subsidence rate of this surgical method was reported from 19.6% to 75% in the literatures, which would cause treatment failure. Thus, an improvement of anterior surgery technique should be studied to reduce these complications. MATERIALS AND METHODS: 130 patients of thoracolumbar burst fractures treated by minimal corpectomy, decompression and U cage, between January 2009 and December 2010 were included in this study...
January 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28216210/prevention-of-proximal-junctional-kyphosis-are-polyaxial-pedicle-screws-superior-to-monoaxial-pedicle-screws-at-the-upper-instrumented-vertebrae
#9
Hui Wang, Wenyuan Ding, Lei Ma, Lijun Zhang, Dalong Yang
INTRODUCTION: Evidence regarding whether the polyaxial pedicle screws at the upper instrumented vertebrae (UIV) are superior to monoaxial pedicle screws in prevention of proximal junctional kyphosis (PJK) is less clear. The aim of this study was therefore to explore the influence of different type of pedicle screws at UIV on the incidence of PJK. METHODS: 242 patients surgically treated with instrumented segmental posterior spinal fusion at a minimum 4 motion segments were reviewed retrospectively...
February 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28213193/anterior-surgical-fixation-for-cervical-spine-flexion-distraction-injuries
#10
Andrew Jack, Godefroy Hardy-St-Pierre, Mitchell Wilson, Godwin Choy, Richard Fox, Andrew Nataraj
BACKGROUND: Optimal surgical management for flexion-distraction cervical spine injuries remains controversial with current guidelines recommending anterior, posterior, and circumferential approaches. Here, we determined the incidence of and examined risk factors for clinical and radiographic failure in patients with one segment cervical distraction injuries having undergone anterior surgical fixation. METHODS: A retrospective review of 57 consecutive patients undergoing anterior fixation for subaxial flexion-distraction cervical injuries between 2008-2012 at our institution was performed...
February 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28209927/improved-health-span-and-lifespan-in-mtdna-mutator-mice-treated-with-the-mitochondrially-targeted-antioxidant-skq1
#11
Irina G Shabalina, Mikhail Yu Vyssokikh, Natalia Gibanova, Robert I Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, Lora E Bakeeva, Valeria B Vays, Antonina V Pustovidko, Maxim V Skulachev, Barbara Cannon, Vladimir P Skulachev, Jan Nedergaard
MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increased mitochondrial ROS released due to mitochondrial mutations probably interact with polyunsaturated fatty acids in cardiolipin, releasing malondialdehyde and 4-hydroxynonenal that form protein adducts and thus diminishes mitochondrial functions...
February 15, 2017: Aging
https://www.readbyqxmd.com/read/28207663/role-of-ethnicity-in-alignment-compensation-propensity-matched-analysis-of-differential-compensatory-mechanism-recruitment-patterns-for-sagittal-malalignment-in-288-asd-patients-from-japan-korea-and-united-states
#12
Bassel G Diebo, Isaac Gammal, Yoon Ha, Seung Hwan Yoon, Jae Won Chang, Byeongwoo Kim, Morio Matsumoto, Yu Yamato, Daisaku Takeuchi, Naobumi Hosogane, Mitsuru Yagi, Hiroshi Taneichi, Frank Schwab, Virginie Lafage, Christopher Ames
STUDY DESIGN: Retrospective review of adult spinal deformity patients in a multiethnic database. OBJECTIVE: To investigate the role of ethnicity on recruitment of compensatory mechanisms for sagittal spinal deformity. SUMMARY OF BACKGROUND DATA: While the impacts of age, sex, and pelvic morphology on the ability to compensate for sagittal malalignment have been investigated, the role of ethnicity in compensatory mechanism recruitment is poorly understood...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28202890/a-case-of-upside-down-stomach-that-was-effectively-treated-by-postprandial-repositioning
#13
Kazumasa Ono, Hiroshi Hasegawa, Toshimasa Obara, Kei Miyagishima, Shinichiro Inoue, Koichi Kozaki
An 88-year-old woman with a history of stomach perforation and lumbar compression fracture was admitted to our hospital with a chief complaint of continuous vomiting, which she had experienced since the previous day. She showed vomiting, spontaneous pain and tenderness from the epigastric fossa through the left flank. In addition, she had marked kyphosis. On a CT scan, although the fornix was located in the abdominal cavity, the antrum and body had escaped into the thoracic cavity. A large volume of gastric content was observed...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28202300/multiple-concave-rib-head-resection-improved-correction-rate-of-posterior-spine-fusion-in-treatment-of-adolescent-idiopathic-scoliosis
#14
Takashi Namikawa, Hiroshi Taneichi, Satoshi Inami, Hiroshi Moridaira, Daisaku Takeuchi, Yo Shiba, Yutaka Nohara
BACKGROUND: Hybrid constructs have been widely used to surgically correct thoracic adolescent idiopathic scoliosis (AIS). To enhance the correction obtained with hybrid constructs, we perform concave rib head resection and convex costovertebral release as posterior release procedures. The objective of the study was to evaluate coronal and sagittal curve correction in patients with adolescent idiopathic scoliosis (AIS) treated with hybrid constructs combined with concave rib head resection and convex transverse process resection as posterior release procedures...
February 12, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28198603/training-intensity-and-sagittal-curvature-of-the-spine-in-male-and-female-artistic-gymnasts
#15
Jose M Sanz-Mengibar, Pilar Sainz-DE-Baranda, Fernando Santonja-Medina
BACKGROUND: Specific adaptations of the spine in the sagittal plane have been described according to different sports disciplines. The goal of this study was to describe the integrative diagnosis of the sagittal morphotype of the spine in male and female artistic gymnasts. METHODS: 48 gymnasts were measured with an inclinometer. Thoracic and Lumbar curves were quantified in standing position, in Sit and Reach and Slump Sitting in order to assess the sagittal spine posture and analyze if adaptations were related to training intensity...
February 14, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28196468/posterior-pedicle-screw-fixation-to-treat-lower-cervical-fractures-associated-with-ankylosing-spondylitis-a-retrospective-study-of-35-cases
#16
Liang Yan, Zhenguo Luo, Baorong He, Jijun Liu, Dingjun Hao
BACKGROUND: The most common site of fractures in patients with ankylosing spondylitis (AS) is the cervical spine, especially the lower cervical spine and cervicothoracic junction. The optimal treatment for cervical spine fractures secondary to AS is controversial. This study aimed to explore the effects of posterior pedicle screw fixation alone on fractures of the lower cervical spine in patients with AS. METHODS: From January 2006 to January 2013, a total of 35 patients with AS and a lower cervical spine fracture were treated using only posterior cervical/thoracic pedicle screw fixation...
February 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28194535/erratum-to-distal-junctional-kyphosis-in-patients-with-scheuermann-s-disease-a-retrospective-radiographic-analysis
#17
Amir Ghasemi, Timo Stubig, Luigi Aurelio Nasto, Malik Ahmed, Hossein Mehdian
No abstract text is available yet for this article.
February 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28193245/early-disease-progression-of-hurler-syndrome
#18
Bridget T Kiely, Jennifer L Kohler, Hannah Y Coletti, Michele D Poe, Maria L Escolar
BACKGROUND: Newborn screening for mucopolysaccharidosis type I (MPS I) shows promise to improve outcomes by facilitating early diagnosis and treatment. However, diagnostic tests for MPS I are of limited value in predicting whether a child will develop severe central nervous system disease associated with Hurler syndrome, or minimal or no central nervous system involvement associated with the attenuated phenotypes (Hurler-Scheie and Scheie syndromes). Given that the optimal treatment differs between Hurler syndrome and the attenuated MPS I phenotypes, the absence of a reliable prognostic biomarker complicates clinical decision making for infants diagnosed through newborn screening...
February 14, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28192267/posterior-only-vertebral-column-resection-for-the-treatment-of-severe-spinal-deformities-in-pediatric-patients-a-retrospective-case-series
#19
Malte Schroeder, Lennart Viezens, Philip Kunkel, Karsten Ridderbusch, Tim Nicolas Hissnauer, Oliver Dirk Jungesblut, Michael Hoffmann, Johannes Maria Rueger, Ralf Stuecker
OBJECTIVE: The treatment of severe spinal deformities in pediatric patients is very challenging. Posterior only vertebral column resection (PVCR) allows for correcting of severe deformities of the vertebral column via a posterior only procedure. We analyzed radiological outcome of PVCR performed on a series of pediatric patients with severe congenital and acquired spinal deformities. METHODS: A case series of eleven pediatric patients with severe spinal deformity who were treated by PVCR between 2009 and 2013 were retrospectively analyzed...
February 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28188490/a-review-of-laser-assisted-versus-traditional-phacoemulsification-cataract-surgery
#20
REVIEW
H Burkhard Dick, Tim Schultz
The use of femtosecond laser surgery improves the precision and reproducibility of corneal incisions and the capsular opening; it also reduces the amount of ultrasound energy required for lens nucleus work-up. The rate of complications reported so far appears to be low. There are a number of contraindications such as a history of cornea and/or glaucoma surgery and certain anatomical features like deep-set eyes, kyphosis, tremor, and obesity. Visual recovery and refractive results of both techniques are excellent...
February 10, 2017: Ophthalmology and Therapy
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