Alberto Sulli, Elvis Hysa, Andrea Cere, Francesca Lalli, Alessandro Pinelli, Silvia Sammorì, Emanuele Gotelli, Carmen Pizzorni, Fransiska Malfait, Marco Castori, Vanessa Smith, Maurizio Cutolo
OBJECTIVES: Hypermobile Ehlers-Danlos Syndrome (hEDS) is a hereditary connective tissue disorder characterised by joint hypermobility, chronic musculoskeletal pain, and skin abnormalities and easy bruising. Morphological and functional microvascular status has not yet been studied in hEDS, and dermal thickness (DT) has been poorly investigated, therefore the aim of our study was to investigate it. METHODS: We conducted a study to investigate microvascular morphology by nailfold videocapillaroscopy (NVC), peripheral blood perfusion (PBP) by laser speckle contrast analysis (LASCA), and DT by high-frequency skin ultrasound (22 MHz probe) in adults with hEDS compared to sex- and age-matched controls...
November 8, 2023: Clinical and Experimental Rheumatology