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https://www.readbyqxmd.com/read/27891730/reduction-in-psoriasis-related-pruritus-during-biologic-therapy
#1
L Lazzeri, L Pescitelli, L Tripo, F Ricceri, F Prignano
No abstract text is available yet for this article.
November 27, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27819713/impairment-of-sexual-life-in-3-485-dermatological-outpatients-from-a-multicentre-study-in-13-european-countries
#2
Francesca Sampogna, Damiano Abeni, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Géraldine Titeca, Gregor B E Jemec, Laurent Misery, Csanád Szabó, M Dennis Linder, Andrea W M Evers, Jon Anders Halvorsen, Flora Balieva, Jacek C Szepietowski, Dmitry V Romanov, Servando E Marron, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Jörg Kupfer, Florence Dalgard
Skin conditions may have a strong impact on patients' sexual life, and thus influence personal relationships. Sexual issues are difficult to discuss directly in clinical practice, and a mediated instrument may be useful to capture such information. In this study item 9 of the Dermatology Life Quality Index was used to collect information on sexual impact of several skin conditions in 13 European countries. Among 3,485 patients, 23.1% reported sexual problems. The impairment was particularly high in patients with hidradenitis suppurativa, prurigo, blistering disorders, psoriasis, urticaria, eczema, infections of the skin, or pruritus...
November 7, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27747909/six-years-experience-of-grenz-ray-therapy-for-the-treatment-of-inflammatory-skin-conditions
#3
L Fenton, R S Dawe
BACKGROUND: In 2008, Ninewells Hospital became the first centre in the UK to offer grenz rays as a treatment for inflammatory dermatoses. Since then, 122 courses have been administered for the following conditions; scalp psoriasis (n = 36), nail dystrophies (n = 27), hyperkeratotic eczema/psoriasis (n = 22), palmoplantar pustulosis (n = 9), perianal pruritus (n = 9), warts (n = 4) and other conditions (n = 15). AIM: To review all patients who received grenz rays in order to determine which conditions have been treated successfully and to estimate remission times...
October 16, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27716172/treatment-of-plaque-psoriasis-with-an-ointment-formulation-of-the-janus-kinase-inhibitor-tofacitinib-a-phase-2b-randomized-clinical-trial
#4
Kim A Papp, Robert Bissonnette, Melinda Gooderham, Steven R Feldman, Lars Iversen, Jennifer Soung, Zoe Draelos, Carla Mamolo, Vivek Purohit, Cunshan Wang, William C Ports
BACKGROUND: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. METHODS: This was a 12-week, randomized, double-blind, parallel-group, vehicle-controlled Phase 2b study of tofacitinib ointment (2 % and 1 %) applied once (QD) or twice (BID) daily in adults with mild to moderate plaque psoriasis...
October 3, 2016: BMC Dermatology
https://www.readbyqxmd.com/read/27692733/tofacitinib-improves-pruritus-and-health-related-quality-of-life-up-to-52%C3%A2-weeks-results-from-2-randomized-phase-iii-trials-in-patients-with-moderate-to-severe-plaque-psoriasis
#5
Steven R Feldman, Diamant Thaçi, Melinda Gooderham, Matthias Augustin, Claudia de la Cruz, Lotus Mallbris, Marjorie Buonanno, Svitlana Tatulych, Mandeep Kaur, Shuping Lan, Hernan Valdez, Carla Mamolo
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor that improves clinical measures of psoriasis. OBJECTIVE: We sought to assess patient-reported outcomes in tofacitinib-treated patients with moderate to severe plaque psoriasis over 52 weeks. METHODS: In 2 identical, phase III studies (Oral treatment for Psoriasis Trial Pivotal 1 [NCT01276639], n = 901, and Pivotal 2 [NCT01309737], n = 960), patients were randomized 2:2:1 to receive 5 or 10 mg of tofacitinib or placebo, twice daily...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27686401/relationships-among-plasma-granzyme-b-level-pruritus-and-dermatitis-in-patients-with-atopic-dermatitis
#6
Yayoi Kamata, Utako Kimura, Hironori Matsuda, Suhandy Tengara, Atsuko Kamo, Yoshie Umehara, Kyoichi Iizumi, Hiroaki Kawasaki, Yasushi Suga, Hideoki Ogawa, Mitsutoshi Tominaga, Kenji Takamori
BACKGROUND: Atopic dermatitis (AD) is a multifactorial inflammatory skin disease characterized by skin barrier dysfunction, allergic inflammation and intractable pruritus resistant to conventional antipruritic treatments, including H1-antihistamines. Granzymes (Gzms) are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer cells that have been shown to modulate inflammation. However, the relationship between Gzms and pathology in AD remains unclear. OBJECTIVE: This study assessed the correlation between plasma GzmB levels and severity of pruritus and dermatitis, in AD patients...
September 15, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27672693/pruritus-since-childhood
#7
Andrea Richardson, Richard P Usatine
The itchy rash had been previously diagnosed as psoriasis. But treatment provided minimal relief. So what was causing the itch?
September 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27660843/severe-pruritus-%C3%A2-crusted-lesions-affecting-face-extremities-and-trunk-%C3%A2-hepatitis-c-virus-carrier-%C3%A2-dx
#8
Tuğba Kevser Uzunçakmak, Ayşe Serap Karadağ, Şeyma Özkanlı, Ebru Itır Zemheri, Mukaddes Kavala, Necmettin Akdeniz
The patient had visited various clinics for her complaints and was diagnosed as having contact dermatitis and senile pruritus. She was prescribed topical mometasone furoate and moisturizers. After 6 months of using this therapy, widespread grey-white plaques and minimal excoriation appeared on her face, scalp, and trunk. This was diagnosed as psoriasis, and the patient was prescribed topical corticosteroids, which she used for 9 months until she came to our clinic.
August 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27649664/pruritus-in-selected-dermatoses
#9
K Olek-Hrab, M Hrab, J Szyfter-Harris, Z Adamski
Pruritus is a natural defence mechanism of the body and creates the scratch reflex as a defensive reaction to potentially dangerous environmental factors. Together with pain, pruritus is a type of superficial sensory experience. Pruritus is a symptom often experienced both in healthy subjects and in those who have symptoms of a disease. In dermatology, pruritus is a frequent symptom associated with a number of dermatoses and is sometimes an auxiliary factor in the diagnostic process. Apart from histamine, the most popular pruritus mediators include tryptase, endothelins, substance P, bradykinin, prostaglandins and acetylcholine...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27578088/itch-management-in-the-elderly
#10
Tabi Anika Leslie
Itch is a common symptom in the elderly population over 65 years old, and is often a chronic condition lasting more than 6 weeks. As in all age groups, but especially in the elderly, there can be a significant effect on the general health status and quality of life, with impaired daily activities and lack of sleep, which can also lead in some cases to depression or anxiety. The cause of chronic itch in the elderly is often multifactorial due to physiological changes in the aging skin, including impaired skin barrier function, and also due to decline in immunological (immunosenescence), neurological, and psychological changes associated with age...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27554821/an-il-17-dominant-immune-profile-is-shared-across-the-major-orphan-forms-of-ichthyosis
#11
Amy S Paller, Yael Renert-Yuval, Maria Suprun, Hitokazu Esaki, Margeaux Oliva, Thy Nhat Huynh, Benjamin Ungar, Norma Kunjravia, Rivka Friedland, Xiangyu Peng, Xiuzhong Zheng, Yeriel D Estrada, James G Krueger, Keith A Choate, Mayte Suárez-Fariñas, Emma Guttman-Yassky
BACKGROUND: The ichthyoses are rare genetic disorders associated with generalized scaling, erythema, and epidermal barrier impairment. Pathogenesis-based therapy is largely lacking, since the underlying molecular basis is poorly understood. OBJECTIVE: To characterize molecularly cutaneous inflammation and its correlation with clinical and barrier characteristics. METHODS: We analyzed biopsies from 21 genotyped ichthyosis patients (congenital ichthyosiform erythroderma (n=6), lamellar ichthyosis (n=7), epidermolytic ichthyosis, (n=5) and Netherton syndrome (n=3)) by immunohistochemistry and RT-PCR and compared them with healthy controls, and atopic dermatitis (AD) and psoriasis patients...
August 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27498667/an-innovative-promising-topical-treatment-for-psoriasis-a-romanian-clinical-study
#12
S Gianfaldoni, J Hercogovấ, M Fioranelli, A A Chokoeva, G Tchernev, U Wollina, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. Even if today many therapeutic options are available for psoriasis treatment, none of them provide excellent clinical results without the risk of side effects...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27498666/scalp-psoriasis-a-promising-natural-treatment
#13
U Wollina, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a lifelong chronic inflammatory disease affecting 2-3% of the worldwide population. Scalp psoriasis is a particular form of psoriasis characterized by lesions on the scalp, which may occur isolated or in association with other skin lesions. The aim of this study was to investigate the efficacy and safeness of an innovative treatment of scalp psoriasis, which is based on the topical application of natural products. Fifty adult subjects with scalp psoriasis (23 females, 27 males) from different European dermatological centres were included in the study...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27460912/current-and-emerging-therapies-for-itch-management-in-psoriasis
#14
REVIEW
Carolyn Stull, Shoshana Grossman, Gil Yosipovitch
Pruritus is a common and significant symptom among patients with psoriasis. Pruritus is often present beyond the borders of psoriatic plaques, and frequently affects the scalp and genital regions. Psoriatic itch may be severe and can profoundly affect quality of life and sleep, even in the context of mild-to-moderate disease. These features often make the treatment of psoriatic pruritus challenging. However, there are a variety of effective topical and systemic treatment modalities available to address this symptom...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27437986/uva1-phototherapy-in-the-treatment-of-palmoplantar-pustulosis-a-pilot-prospective-study
#15
Li-Na Su, Xin Xu, Li Tang, Ning Yu, Yang-Feng Ding
Palmoplantar pustulosis (PPP) is recalcitrant to traditional topical and systemic therapies. Ultraviolet A1 (UVA1) phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of PPP. The purpose of this study was to evaluate the efficacy and safety of UVA1 therapy for the treatment of PPP. Patients with PPP were treated with UVA1 irradiation three times a week for up to 30 sessions and had a 3-month follow-up visit. UVA1 therapy was conducted with a fixed dose (80 J/cm(2))...
November 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27376751/-pruritus-in-psoriasis-profile-and-therapy
#16
A Tsianakas, U Mrowietz
Psoriasis is a common chronic inflammatory disease with an incidence of about 0.5-3 %. Previously psoriasis was not primarily regarded to be associated with pruritus; however, this perception has changed in recent years. Meanwhile data conclusively show that between 64 and 97 % of patients report about pruritus that can be severe in a number of cases. Apart from suffering from psoriasis, the presence of pruritus causes additional stress and leads to a significant impairment of health-related quality of life...
August 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27335049/tolerability-of-crisaborole-ointment-for-application-on-sensitive-skin-areas-a-randomized-double-blind-vehicle-controlled-study-in-healthy-volunteers
#17
Lee T Zane, Matilda H Hughes, Sepehr Shakib
BACKGROUND: Inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis often present in sensitive and thin-skinned areas that are at higher risk for topical treatment-related skin irritation (e.g., burning, stinging). OBJECTIVES: Our objective was to address the need for topical treatments that can be safely applied to these areas. We assessed the local tolerability of crisaborole topical ointment when applied to sensitive and thin-skinned areas of healthy volunteers...
October 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27282194/interplay-of-itch-and-psyche-in-psoriasis-an-update
#18
Adam Reich, Karolina Mędrek, Jacek C Szepietowski
Itch or pruritus is defined as an unpleasant subjective sensation leading to the need or to the idea of scratching. A number of studies have shown that pruritus is often responsible for marked morbidity, quality of life impairment, and even for increased mortality. Patients suffering from chronic pruritus had also decreased self-esteem, suffer from anxiety or depression and have problems to cope with negative feelings. Several studies documented that itching is a very prevalent symptom of psoriasis affecting more than 70% of individuals and for many patient it is the most bothersome symptom of the disease...
August 23, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27259580/health-related-quality-of-life-in-patients-with-psoriasis-a-systematic-review-of-the-european-literature
#19
Montse Obradors, Carles Blanch, Marta Comellas, Montse Figueras, Luis Lizan
PURPOSE: To summarize the data published over the last 5 years in the European Union related to the health-related quality of life (HRQoL) of patients with psoriasis and its conditioning factors. METHODS: International electronic databases and gray literature were searched to identify studies conducted on patient-reported outcomes in patients with psoriasis, published in Europe between January 1, 2009 and December 31, 2013. Bibliographic references were hand-searched...
June 3, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27229771/physiological-and-microbiological-verification-of-the-benefit-of-hair-washing-in-patients-with-skin-conditions-of-the-scalp
#20
Miwa Kobayashi, Kei Ito, Takashi Sugita, Yumi Murakami, Ryoko Yamashita, Hiroshi Matsunaka, Motonobu Nakamura
BACKGROUND: It is unclear whether hair washing is effective against scalp eruption and pruritus caused by seborrheic dermatitis or psoriasis vulgaris. AIMS: To assess whether a proper hair-washing regimen, including the use of antibacterial shampoo, can ameliorate scalp eruption symptoms and alter the composition of the scalp microflora. METHODS: Eighteen patients with seborrheic dermatitis or psoriasis vulgaris scalp eruptions were instructed in proper techniques of daily hair washing, rinsing, and shampooing, which they underwent for 12 weeks...
May 26, 2016: Journal of Cosmetic Dermatology
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