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https://www.readbyqxmd.com/read/28213862/apremilast-a-review-in-psoriasis-and-psoriatic-arthritis
#1
Gillian M Keating
Apremilast (Otezla(®)) is an orally administered, small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast 30 mg twice daily reduced the severity of moderate to severe plaque psoriasis in the phase 3 ESTEEM trials, as well as improving difficult-to-treat nail, scalp and palmoplantar psoriasis. Most patient-reported outcomes, including pruritus and the total Dermatology Life Quality Index, also improved to a significantly greater extent with apremilast than with placebo, with significant improvements in pruritus and skin discomfort/pain visual analogue scale scores seen as early as week 2 with apremilast...
February 18, 2017: Drugs
https://www.readbyqxmd.com/read/28196317/common-skin-conditions-in-children-noninfectious-rashes
#2
Brian Z Rayala, Dean S Morrell
Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Emollients and topical corticosteroids are first-line therapies. Topical calcineurin inhibitors are second-line, steroid-sparing drugs for certain conditions, such as face and eyelid eczema...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28124078/primary-biliary-cholangitis-associated-with-skin-disorders-a-case-report-and-review-of-the-literature
#3
REVIEW
Benedetta Terziroli Beretta-Piccoli, Caroline Guillod, Igor Marsteller, Roland Blum, Luca Mazzucchelli, Chiara Mondino, Pietro Invernizzi, M Eric Gershwin, Carlo Mainetti
Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease. It is often associated with extrahepatic autoimmune diseases. Skin disorders are sporadically reported in association with PBC. We report an unusual case of PBC associated with acquired reactive perforating dermatosis (ARPD) and present a review of the literature on skin disorders associated with PBC. Our patient presented to the dermatology department with generalized pruritus associated with nodular perforating skin lesions on the trunk, and cholestatic liver disease of unknown origin...
January 25, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27943234/immune-related-alopecia-areata-and-universalis-type-in-cancer-patients-receiving-immune-checkpoint-inhibitors
#4
A Zarbo, V R Belum, V Sibaud, S Oudard, M A Postow, J J Hsieh, R J Motzer, K J Busam, M E Lacouture
CTLA-4, PD-1, and PD-L1 monoclonal antibodies, commonly known as immune checkpoint inhibitors, are used for the treatment of various malignancies. The mechanism of action involves the inhibition of negative regulators of immune activation, which results in many patients developing immune-related adverse events (irAEs) including endocrinopathies, pneumonitis, colitis, hepatitis and dermatologic events. Dermatologic irAEs include maculopapular rash, pruritus, vitiligo, blistering disorders, mucocutaneous lichenoid eruptions, rosacea, and exacerbation of psoriasis...
December 11, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27891730/reduction-in-psoriasis-related-pruritus-during-biologic-therapy
#5
L Lazzeri, L Pescitelli, L Tripo, F Ricceri, F Prignano
No abstract text is available yet for this article.
November 27, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27819713/impairment-of-sexual-life-in-3-485-dermatological-outpatients-from-a-multicentre-study-in-13-european-countries
#6
Francesca Sampogna, Damiano Abeni, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Géraldine Titeca, Gregor B E Jemec, Laurent Misery, Csanád Szabó, M Dennis Linder, Andrea W M Evers, Jon Anders Halvorsen, Flora Balieva, Jacek C Szepietowski, Dmitry V Romanov, Servando E Marron, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Jörg Kupfer, Florence Dalgard
Skin conditions may have a strong impact on patients' sexual life, and thus influence personal relationships. Sexual issues are difficult to discuss directly in clinical practice, and a mediated instrument may be useful to capture such information. In this study item 9 of the Dermatology Life Quality Index was used to collect information on sexual impact of several skin conditions in 13 European countries. Among 3,485 patients, 23.1% reported sexual problems. The impairment was particularly high in patients with hidradenitis suppurativa, prurigo, blistering disorders, psoriasis, urticaria, eczema, infections of the skin, or pruritus...
November 7, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27747909/six-years-experience-of-grenz-ray-therapy-for-the-treatment-of-inflammatory-skin-conditions
#7
L Fenton, R S Dawe
BACKGROUND: In 2008, Ninewells Hospital became the first centre in the UK to offer grenz rays as a treatment for inflammatory dermatoses. Since then, 122 courses have been administered for the following conditions; scalp psoriasis (n = 36), nail dystrophies (n = 27), hyperkeratotic eczema/psoriasis (n = 22), palmoplantar pustulosis (n = 9), perianal pruritus (n = 9), warts (n = 4) and other conditions (n = 15). AIM: To review all patients who received grenz rays in order to determine which conditions have been treated successfully and to estimate remission times...
December 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27716172/treatment-of-plaque-psoriasis-with-an-ointment-formulation-of-the-janus-kinase-inhibitor-tofacitinib-a-phase-2b-randomized-clinical-trial
#8
Kim A Papp, Robert Bissonnette, Melinda Gooderham, Steven R Feldman, Lars Iversen, Jennifer Soung, Zoe Draelos, Carla Mamolo, Vivek Purohit, Cunshan Wang, William C Ports
BACKGROUND: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of psoriasis. METHODS: This was a 12-week, randomized, double-blind, parallel-group, vehicle-controlled Phase 2b study of tofacitinib ointment (2 % and 1 %) applied once (QD) or twice (BID) daily in adults with mild to moderate plaque psoriasis...
October 3, 2016: BMC Dermatology
https://www.readbyqxmd.com/read/27692733/tofacitinib-improves-pruritus-and-health-related-quality-of-life-up-to-52%C3%A2-weeks-results-from-2-randomized-phase-iii-trials-in-patients-with-moderate-to-severe-plaque-psoriasis
#9
Steven R Feldman, Diamant Thaçi, Melinda Gooderham, Matthias Augustin, Claudia de la Cruz, Lotus Mallbris, Marjorie Buonanno, Svitlana Tatulych, Mandeep Kaur, Shuping Lan, Hernan Valdez, Carla Mamolo
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor that improves clinical measures of psoriasis. OBJECTIVE: We sought to assess patient-reported outcomes in tofacitinib-treated patients with moderate to severe plaque psoriasis over 52 weeks. METHODS: In 2 identical, phase III studies (Oral treatment for Psoriasis Trial Pivotal 1 [NCT01276639], n = 901, and Pivotal 2 [NCT01309737], n = 960), patients were randomized 2:2:1 to receive 5 or 10 mg of tofacitinib or placebo, twice daily...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27686401/relationships-among-plasma-granzyme-b-level-pruritus-and-dermatitis-in-patients-with-atopic-dermatitis
#10
Yayoi Kamata, Utako Kimura, Hironori Matsuda, Suhandy Tengara, Atsuko Kamo, Yoshie Umehara, Kyoichi Iizumi, Hiroaki Kawasaki, Yasushi Suga, Hideoki Ogawa, Mitsutoshi Tominaga, Kenji Takamori
BACKGROUND: Atopic dermatitis (AD) is a multifactorial inflammatory skin disease characterized by skin barrier dysfunction, allergic inflammation and intractable pruritus resistant to conventional antipruritic treatments, including H1-antihistamines. Granzymes (Gzms) are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer cells that have been shown to modulate inflammation. However, the relationship between Gzms and pathology in AD remains unclear. OBJECTIVE: This study assessed the correlation between plasma GzmB levels and severity of pruritus and dermatitis, in AD patients...
December 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27672693/pruritus-since-childhood
#11
Andrea Richardson, Richard P Usatine
The itchy rash had been previously diagnosed as psoriasis. But treatment provided minimal relief. So what was causing the itch?
September 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27660843/severe-pruritus-%C3%A2-crusted-lesions-affecting-face-extremities-and-trunk-%C3%A2-hepatitis-c-virus-carrier-%C3%A2-dx
#12
Tuğba Kevser Uzunçakmak, Ayşe Serap Karadağ, Şeyma Özkanlı, Ebru Itır Zemheri, Mukaddes Kavala, Necmettin Akdeniz
The patient had visited various clinics for her complaints and was diagnosed as having contact dermatitis and senile pruritus. She was prescribed topical mometasone furoate and moisturizers. After 6 months of using this therapy, widespread grey-white plaques and minimal excoriation appeared on her face, scalp, and trunk. This was diagnosed as psoriasis, and the patient was prescribed topical corticosteroids, which she used for 9 months until she came to our clinic.
August 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/27649664/pruritus-in-selected-dermatoses
#13
K Olek-Hrab, M Hrab, J Szyfter-Harris, Z Adamski
Pruritus is a natural defence mechanism of the body and creates the scratch reflex as a defensive reaction to potentially dangerous environmental factors. Together with pain, pruritus is a type of superficial sensory experience. Pruritus is a symptom often experienced both in healthy subjects and in those who have symptoms of a disease. In dermatology, pruritus is a frequent symptom associated with a number of dermatoses and is sometimes an auxiliary factor in the diagnostic process. Apart from histamine, the most popular pruritus mediators include tryptase, endothelins, substance P, bradykinin, prostaglandins and acetylcholine...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27578088/itch-management-in-the-elderly
#14
Tabi Anika Leslie
Itch is a common symptom in the elderly population over 65 years old, and is often a chronic condition lasting more than 6 weeks. As in all age groups, but especially in the elderly, there can be a significant effect on the general health status and quality of life, with impaired daily activities and lack of sleep, which can also lead in some cases to depression or anxiety. The cause of chronic itch in the elderly is often multifactorial due to physiological changes in the aging skin, including impaired skin barrier function, and also due to decline in immunological (immunosenescence), neurological, and psychological changes associated with age...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27554821/an-il-17-dominant-immune-profile-is-shared-across-the-major-orphan-forms-of-ichthyosis
#15
Amy S Paller, Yael Renert-Yuval, Maria Suprun, Hitokazu Esaki, Margeaux Oliva, Thy Nhat Huynh, Benjamin Ungar, Norma Kunjravia, Rivka Friedland, Xiangyu Peng, Xiuzhong Zheng, Yeriel D Estrada, James G Krueger, Keith A Choate, Mayte Suárez-Fariñas, Emma Guttman-Yassky
BACKGROUND: The ichthyoses are rare genetic disorders associated with generalized scaling, erythema, and epidermal barrier impairment. Pathogenesis-based therapy is largely lacking because the underlying molecular basis is poorly understood. OBJECTIVE: We sought to characterize molecularly cutaneous inflammation and its correlation with clinical and barrier characteristics. METHODS: We analyzed biopsy specimens from 21 genotyped patients with ichthyosis (congenital ichthyosiform erythroderma, n = 6; lamellar ichthyosis, n = 7; epidermolytic ichthyosis, n = 5; and Netherton syndrome, n = 3) using immunohistochemistry and RT-PCR and compared them with specimens from healthy control subjects, patients with atopic dermatitis (AD), and patients with psoriasis...
August 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27498667/an-innovative-promising-topical-treatment-for-psoriasis-a-romanian-clinical-study
#16
S Gianfaldoni, J Hercogovấ, M Fioranelli, A A Chokoeva, G Tchernev, U Wollina, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a chronic inflammatory disease with negative impacts both physically and psychologically. It is a common disorder affecting 2-3% of the total world population, in some cases causing changes to the nail and joints as well as skin lesions. The cutaneous manifestations of psoriasis can vary in morphology and severity and therapy should be tailored accordingly. Even if today many therapeutic options are available for psoriasis treatment, none of them provide excellent clinical results without the risk of side effects...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27498666/scalp-psoriasis-a-promising-natural-treatment
#17
U Wollina, J Hercogovấ, M Fioranelli, S Gianfaldoni, A A Chokoeva, G Tchernev, M Tirant, F Novotny, M G Roccia, G K Maximov, K França, T Lotti
Psoriasis is a lifelong chronic inflammatory disease affecting 2-3% of the worldwide population. Scalp psoriasis is a particular form of psoriasis characterized by lesions on the scalp, which may occur isolated or in association with other skin lesions. The aim of this study was to investigate the efficacy and safeness of an innovative treatment of scalp psoriasis, which is based on the topical application of natural products. Fifty adult subjects with scalp psoriasis (23 females, 27 males) from different European dermatological centres were included in the study...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27460912/current-and-emerging-therapies-for-itch-management-in-psoriasis
#18
REVIEW
Carolyn Stull, Shoshana Grossman, Gil Yosipovitch
Pruritus is a common and significant symptom among patients with psoriasis. Pruritus is often present beyond the borders of psoriatic plaques, and frequently affects the scalp and genital regions. Psoriatic itch may be severe and can profoundly affect quality of life and sleep, even in the context of mild-to-moderate disease. These features often make the treatment of psoriatic pruritus challenging. However, there are a variety of effective topical and systemic treatment modalities available to address this symptom...
December 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27437986/uva1-phototherapy-in-the-treatment-of-palmoplantar-pustulosis-a-pilot-prospective-study
#19
Li-Na Su, Xin Xu, Li Tang, Ning Yu, Yang-Feng Ding
Palmoplantar pustulosis (PPP) is recalcitrant to traditional topical and systemic therapies. Ultraviolet A1 (UVA1) phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of PPP. The purpose of this study was to evaluate the efficacy and safety of UVA1 therapy for the treatment of PPP. Patients with PPP were treated with UVA1 irradiation three times a week for up to 30 sessions and had a 3-month follow-up visit. UVA1 therapy was conducted with a fixed dose (80 J/cm(2))...
November 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27376751/-pruritus-in-psoriasis-profile-and-therapy
#20
A Tsianakas, U Mrowietz
Psoriasis is a common chronic inflammatory disease with an incidence of about 0.5-3 %. Previously psoriasis was not primarily regarded to be associated with pruritus; however, this perception has changed in recent years. Meanwhile data conclusively show that between 64 and 97 % of patients report about pruritus that can be severe in a number of cases. Apart from suffering from psoriasis, the presence of pruritus causes additional stress and leads to a significant impairment of health-related quality of life...
August 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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