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Pruritus, psoriasis

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https://www.readbyqxmd.com/read/29904567/serum-25-hydroxyvitamin-d-levels-in-patients-with-skin-diseases-including-psoriasis-infections-and-atopic-dermatitis
#1
Ulrich Amon, Laura Baier, Raul Yaguboglu, Madeleine Ennis, Michael F Holick, Julian Amon
The pathogenetic role of vitamin D as well as its clinical correlation in inflammatory skin diseases is still uncertain. This study aimed to compare serum levels of 25(OH) vitamin D (calcidiol) in outpatients suffering from different skin diseases using the same laboratory method in one study. In routine serum samples of 1,532 patients from the previous 12 months we identified retrospectively 180 (mean age 49.4 years, 80 female, 100 male) and 205 (mean age 36.3 years, 116 female, 89 male) patients with psoriasis (PSO) and atopic dermatitis (AD), respectively...
2018: Dermato-endocrinology
https://www.readbyqxmd.com/read/29879253/from-probiotic-to-prebiotic-using-thermal-spring-water
#2
Joshua Zeichner, Sophie Seite
BACKGROUND: La Roche-Posay Thermal Spring Water (LRP-TSW) exhibits both probiotic and prebiotic properties enhancing the diversity of the skin microbiota. METHODS: A review was undertaken to explore the role of LRP-TSW as a topical probiotic and prebiotic therapy in improving the diversity of the skin microbiota and reducing dryness and pruritus in inflammatory skin diseases. RESULTS: The concentration of minerals and non-pathogenic microbes in LRP-TSW may explain its therapeutic benefit when used for inflammatory skin diseases...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29876613/-pruritus-in-germany-a-google-search-engine-analysis
#3
A Zink, M Rüth, B Schuster, U Darsow, T Biedermann, S Ständer
BACKGROUND: Because affected persons often do not visit a doctor, the prevalence of chronic and acute pruritus in the general population is difficult to determine. OBJECTIVES: The aim of this study is to estimate the frequency and the most common locations of pruritus in German internet users, who-with 62.4 million persons-represent a large majority of the German population, by analysing the Google search volume. MATERIALS AND METHODS: Relevant keywords for the subject "pruritus" were identified and analysed using the Google AdWords Keyword Planner...
June 6, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29795283/positive-effects-of-hydrogen-water-bathing-in-patients-of-psoriasis-and-parapsoriasis-en-plaques
#4
Qinyuan Zhu, Yueshen Wu, Yongmei Li, Zihua Chen, Lanting Wang, Hao Xiong, Erhong Dai, Jianhua Wu, Bin Fan, Li Ping, Xiaoqun Luo
Psoriasis and parapsoriasis en plaques are chronic inflammatory skin diseases, both representing therapeutic challenge in daily practice and adversely affecting the quality of life. Reactive oxygen species (ROS) has been evidenced to be involved in the pathogenesis of the chronic inflammatory diseases. We now report that hydrogen water, an effective ROS scavenger, has significant and rapid improvement in disease severity and quality of life for patients with psoriasis and parapsoriasis en plaques. At week 8, our parallel-controlled trial revealed 24...
May 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29771216/mindfulness-based-cognitive-hypnotherapy-and-skin-disorders
#5
Philip D Shenefelt
Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo...
July 2018: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/29754191/the-unique-molecular-signatures-of-contact-dermatitis-and-implications-for-treatment
#6
REVIEW
Alexandra Leonard, Emma Guttman-Yassky
Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are common skin disorders that are characterized by inflammation, oozing, crusting, and pruritus. Atopic dermatitis (AD) is an inflammatory skin disease characterized by immune and barrier abnormalities and is additionally a risk factor for acquiring ICD and ACD. New work on allergic sensitization to common allergens (e.g., nickel and fragrance) in human skin has shown that different allergens have distinct molecular fingerprinting. For example, nickel promotes strong Th1/Th17 polarization, whereas fragrance allergy causes Th2/Th22 skewing, which is similar to the phenotype of AD...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29678394/-dermatologic-toxicities-of-immune-checkpoint-inhibitors
#7
REVIEW
V Sibaud, S Boulinguez, C Pagès, L Riffaud, L Lamant, C Chira, S Boyrie, E Vigarios, E Tournier, N Meyer
The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. In this context, dermatological toxicity is the most common, though it mostly remains mild to moderate and does not require discontinuation of treatment...
May 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29671665/effects-of-etanercept-on-the-patient-perceived-results-pros-in-patients-with-moderate-to-severe-plaque-psoriasis-systematic-review-of-the-literature-and-meta-analysis
#8
Jose Manuel Carrascosa, Francisco Rebollo, Susana Gómez, Plablo De-la-Cueva
PURPOSE: To evaluate the efficacy of etanercept (ETN) compared with placebo for moderate-to-severe psoriasis regarding patient-reported outcomes (PROs). METHODS: Systematic review of studies retrieved by a sensitive search strategy in Medline, Embase, Cochrane Library. SELECTION CRITERIA: (population) studies had to include patients with for moderate-to-severe psoriasis; (intervention and control) studies had to test ETN vs. placebo; and (outcomes), studies had to report PROs including quality of life, pain, pruritus, or sleep...
May 8, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29660300/the-major-orphan-forms-of-ichthyosis-are-characterized-by-systemic-t-cell-activation-and-th-17-tc-17-th-22-tc-22-polarization-in-blood
#9
Tali Czarnowicki, Helen He, Alexandra Leonard, Kunal Malik, Shai Magidi, Stephanie Rangel, Krishna Patel, Kara Ramsey, Morgan Murphrey, Teresa Song, Yeriel Estrada, Hue-Chi Wen, James G Krueger, Emma Guttman-Yassky, Amy S Paller
The ichthyoses are rare skin disorders with immune and barrier aberrations. Identifying blood phenotypes may advance targeted therapeutics. We aimed to compare frequencies of skin homing/cutaneous lymphocyte antigen (+) versus systemic/cutaneous lymphocyte antigen (-) "polar" CD4+ /CD8+ and activated T-cell subsets in ichthyosis versus atopic dermatitis, psoriasis, and control blood, with appropriate clinical correlations. Flow cytometry was used to measure IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines in CD4+ /CD8+ T cells, with inducible co-stimulator molecule and HLA-DR defining mid- and long-term T-cell activation, respectively...
April 14, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29653408/a-new-flavonoid-from-stellera-chamaejasme-l-stechamone-alleviated-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-a-murine-model
#10
Beom-Geun Jo, No-June Park, Jonghwan Jegal, Sangho Choi, Sang Woo Lee, Hang Jin, Su-Nam Kim, Min Hye Yang
Stellera chamaejasme L. (family Thymelaeaceae), also known as 'Langdu', has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of S. chamaejasme and evaluate its preventive effects on IL-4 and mast cell degranulation in RBL-2H3 cells and on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-treated SKH-1 hairless mice. A novel flavonoid, genkwanin 5-O-xylosyl(1 → 2)glucoside (named stechamone), and three known compounds (umbelliferone, luteolin, and luteolin-7-O-glucoside) were isolated from the aerial parts of S...
June 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29518197/multipolarity-of-cytokine-axes-in-the-pathogenesis-of-atopic-dermatitis-in-terms-of-age-race-species-disease-stage-and-biomarkers
#11
Takashi Nomura, Tetsuya Honda, Kenji Kabashima
Atopic dermatitis (AD) is a common T-cell-mediated inflammatory disease of the skin. Signatures of AD are characterized by an impaired skin barrier, aberrant Th2-type cytokine production and intensive pruritus. Transcriptomic analysis, however, has revealed a heterogeneous pathogenesis and the co-existence of multiple cytokine axes of Th17, Th22 and Th1 types, especially in intrinsic (a subtype of AD without skin barrier impairment), pediatric and Asian types of AD. Furthermore, the therapeutic effect of anti-IL-4 receptor α against AD was not as high as that of IL-17 blockage against psoriasis, which implies a modification of the disease spectrum by non-Th2-type cytokine axes in AD...
March 6, 2018: International Immunology
https://www.readbyqxmd.com/read/29507561/antihistamines-in-the-treatment-of-pruritus-in-psoriasis
#12
Anna Domagała, Jacek Szepietowski, Adam Reich
Aim: To evaluate the efficacy of antihistamines in reducing pruritus in psoriasis, 61 patients were randomized to be treated for 1 week with clemastine ( n = 20), levocetirizine ( n = 21) or placebo ( n = 20). Material and methods: All patients received the same routine antipsoriatic treatment. Itch intensity was assessed with VAS and the Itch Questionnaire, and hand movements during sleep were counted with an accelerometer. Results: There was a statistically significant decrease in mean VAS scoring in clemastine and levocetirizine groups ( p < 0...
October 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29431216/mast-cell-neural-interactions-contribute-to-pain-and-itch
#13
REVIEW
Kalpna Gupta, Ilkka T Harvima
Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a "power house" by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29317264/the-genetics-of-chronic-itch-gene-expression-in-the-skin-of-patients-with-atopic-dermatitis-and-psoriasis-with-severe-itch
#14
Leigh A Nattkemper, Hong Liang Tey, Rodrigo Valdes-Rodriguez, Helen Lee, Nicholas K Mollanazar, Christian Albornoz, Kristen M Sanders, Gil Yosipovitch
To identify itch-related mediators and receptors that are differentially expressed in pruritic skin, we used RNA sequencing to analyze the complete transcriptome in skin from paired itchy, lesional and nonitchy, nonlesional skin biopsies from 25 patients with atopic dermatitis and 25 patients with psoriasis and site-matched biopsies from 30 healthy controls. This analysis identified 18,000 differentially expressed genes common between itchy atopic and psoriatic skin compared with healthy skin. Of those, almost 2,000 genes were differentially expressed between itchy and nonitchy skin in atopic and psoriatic subjects...
January 6, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29304933/comparison-of-adalimumab-and-etanercept-for-the-treatment-of-moderate-to-severe-psoriasis-an-indirect-comparison-using-individual-patient-data-from-randomized-trials
#15
COMPARATIVE STUDY
Kim A Papp, Min Yang, Murali Sundaram, John Jarvis, Keith A Betts, Yanjun Bao, James E Signorovitch
OBJECTIVES: To compare outcomes between adalimumab and etanercept in the treatment of moderate to severe plaque psoriasis. METHODS: Study groups included patients randomized to adalimumab or placebo (REVEAL and CHAMPION trials) and those randomized to etanercept or placebo (M10-114 and M10-315 trials). Week 12 outcomes were compared between patients receiving adalimumab and those receiving etanercept after adjusting for cross-trial differences in patient characteristics using propensity score weighting and after subtracting effects of placebo...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29280133/itching-for-answers-prevalence-and-severity-of-pruritus-in-psoriasis
#16
Philippa Dickison, Grace Swain, Jonathan J Peek, Saxon D Smith
BACKGROUND/OBJECTIVES: Pruritus is the most frequently reported complaint or symptom for psoriasis patients. Despite the morbidity associated with pruritus in psoriasis few studies have evaluated the prevalence of itch in psoriasis with the current use of biological agents. METHOD: This was a multi-site cross-sectional observational study conducted in New South Wales, Australia. Psoriasis patients were approached during their outpatient clinic, phototherapy or private consultations...
December 26, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29220542/safety-and-efficacy-of-apremilast-through-104-weeks-in-patients-with-moderate-to-severe-psoriasis-who-continued-on-apremilast-or-switched-from-etanercept-treatment-findings-from-the-liberate-study
#17
K Reich, M Gooderham, A Bewley, L Green, J Soung, R Petric, J Marcsisin, J Cirulli, R Chen, V Piguet
BACKGROUND: Apremilast, an oral phosphodiesterase-4 inhibitor, has demonstrated efficacy in patients with moderate to severe psoriasis. OBJECTIVE: To evaluate long-term efficacy and safety of apremilast in biologic-naive patients with moderate to severe plaque psoriasis and safety of switching from etanercept to apremilast in the phase 3b LIBERATE trial. METHODS: Two hundred fifty patients were randomized to placebo, apremilast 30 mg BID or etanercept 50 mg QW through Week 16; thereafter, all patients continued or switched to apremilast through Week 104 (extension phase)...
March 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29182790/validation-of-the-itch-severity-item-as-a-measurement-tool-for-pruritus-in-patients-with-psoriasis-results-from-a-phase-3-tofacitinib-program
#18
Sonja Ständer, Thomas Luger, Joseph C Cappelleri, Andrew G Bushmakin, Carla Mamolo, Michael A Zielinski, Anna M Tallman, Gil Yosipovitch
Tofacitinib is an oral Janus kinase inhibitor. This post-hoc analysis aimed to investigate the psychometric properties of the Itch Severity Item (ISI), a numeric rating scale from 0 (no itching) to 10 (worst possible itching) for pruritus in psoriasis, and review the effect of tofacitinib on pruritus in patients with psoriasis participating in Phase 3 studies (N = 3,641). The ISI showed high test-retest reliability (intra-class correlation coefficient: 0.84). The clinically important difference was defined as a 1...
March 13, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29056081/the-risks-and-benefits-of-cannabis-in-the-dermatology-clinic
#19
Gurbir Dhadwal, Mark G Kirchhof
Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency...
March 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28983980/three-cases-of-facial-erythema-with-dryness-and-pruritus-in-psoriasis-patients-during-treatment-with-il-17-inhibitors
#20
LETTER
T Oiwa, T Honda, A Otsuka, K Kabashima
No abstract text is available yet for this article.
April 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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