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Keywords Associative memory genetic cir...

Associative memory genetic circuits

https://read.qxmd.com/read/38493320/distinct-electrophysiological-properties-of-long-range-gabaergic-and-glutamatergic-neurons-from-the-lateral-amygdala-to-the-auditory-cortex-of-the-mouse
#1
JOURNAL ARTICLE
Alice Bertero, Alfonso Junior Apicella
Differentiating between auditory signals of various emotional significance plays a crucial role in an individual's ability to thrive and excel in social interactions and in survival. Multiple approaches, including anatomical studies, electrophysiological investigations, imaging techniques, optogenetics and chemogenetics, have confirmed that the auditory cortex (AC) impacts fear-related behaviours driven by auditory stimuli by conveying auditory information to the lateral amygdala (LA) through long-range excitatory glutamatergic and GABAergic connections...
March 17, 2024: Journal of Physiology
https://read.qxmd.com/read/38303709/ventral-hippocampal-cholecystokinin-interneurons-gate-contextual-reward-memory
#2
JOURNAL ARTICLE
Robin Nguyen, Sanghavy Sivakumaran, Evelyn K Lambe, Jun Chul Kim
Associating contexts with rewards depends on hippocampal circuits, with local inhibitory interneurons positioned to play an important role in shaping activity. Here, we demonstrate that the encoding of context-reward memory requires a ventral hippocampus (vHPC) to nucleus accumbens (NAc) circuit that is gated by cholecystokinin (CCK) interneurons. In a sucrose conditioned place preference (CPP) task, optogenetically inhibiting vHPC-NAc terminals impaired the acquisition of place preference. Transsynaptic rabies tracing revealed vHPC-NAc neurons were monosynaptically innervated by CCK interneurons...
February 16, 2024: IScience
https://read.qxmd.com/read/38070077/behavioral-tests-for-associative-learning-in-caenorhabditis-elegans
#3
JOURNAL ARTICLE
Aelon Rahmani, Anna McMillen, Ericka Allen, Caitlin Minervini, Yee Lian Chew
Learning is critical for survival as it provides the capacity to adapt to a changing environment. At the molecular and cellular level, learning leads to alterations within neural circuits that include synaptic rewiring, synaptic plasticity, and protein level/gene expression changes. There has been substantial progress in recent years on dissecting how learning and memory is regulated at the molecular and cellular level, including the use of compact invertebrate nervous systems as experimental models. This progress has been facilitated by the establishment of robust behavioral assays that generate a quantifiable readout of the extent to which animals learn and remember...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38050081/activity-dependent-stabilization-of-nascent-dendritic-spines-requires-non-enzymatic-camkii%C3%AE-function
#4
JOURNAL ARTICLE
Nicole Claiborne, Margarita Anisimova, Karen Zito
The outgrowth and stabilization of nascent dendritic spines are crucial processes underlying learning and memory. Most new spines retract shortly after growth; only a small subset is stabilized and integrated into the new circuit connections that support learning. New spine stabilization has been shown to rely upon activity-dependent molecular mechanisms that also contribute to long-term potentiation (LTP) of synaptic strength. Indeed, disruption of the activity-dependent targeting of the kinase CaMKIIα to the GluN2B subunit of the NMDA-type glutamate receptor disrupts both LTP and activity-dependent stabilization of new spines...
November 27, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37884748/neuronal-types-in-the-mouse-amygdala-and-their-transcriptional-response-to-fear-conditioning
#5
JOURNAL ARTICLE
Hannah Hochgerner, Shelly Singh, Muhammad Tibi, Zhige Lin, Niv Skarbianskis, Inbal Admati, Osnat Ophir, Nuphar Reinhardt, Shai Netser, Shlomo Wagner, Amit Zeisel
The amygdala is a brain region primarily associated with emotional response. The use of genetic markers and single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present a detailed cell-type taxonomy of the adult mouse amygdala during fear learning and memory consolidation. We perform single-cell RNA sequencing on naïve and fear-conditioned mice, identify 130 neuronal cell types and validate their spatial distributions. A subset of all neuronal types is transcriptionally responsive to fear learning and memory retrieval...
October 26, 2023: Nature Neuroscience
https://read.qxmd.com/read/37876798/pre-and-postsynaptic-n-methyl-d-aspartate-receptors-are-required-for-sequential-printing-of-fear-memory-engrams
#6
JOURNAL ARTICLE
Ilaria Bertocchi, Florbela Rocha-Almeida, María Teresa Romero-Barragán, Marco Cambiaghi, Alejandro Carretero-Guillén, Paolo Botta, Godwin K Dogbevia, Mario Treviño, Paolo Mele, Alessandra Oberto, Matthew E Larkum, Agnes Gruart, Rolf Sprengel, José Maria Delgado-García, Mazahir T Hasan
The organization of fear memory involves the participation of multiple brain regions. However, it is largely unknown how fear memory is formed, which circuit pathways are used for "printing" memory engrams across brain regions, and the role of identified brain circuits in memory retrieval. With advanced genetic methods, we combinatorially blocked presynaptic output and manipulated N-methyl-D-aspartate receptor (NMDAR) in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) before and after cued fear conditioning...
November 17, 2023: IScience
https://read.qxmd.com/read/37864255/modelling-tdp-43-proteinopathy-in-drosophila-uncovers-shared-and-neuron-specific-targets-across-als-and-ftd-relevant-circuits
#7
JOURNAL ARTICLE
R Keating Godfrey, Eric Alsop, Reed T Bjork, Brijesh S Chauhan, Hillary C Ruvalcaba, Jerry Antone, Lauren M Gittings, Allison F Michael, Christi Williams, Grace Hala'ufia, Alexander D Blythe, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, Daniela C Zarnescu
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comprise a spectrum of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is characterized by loss of nuclear TDP-43 and accumulation of cytoplasmic TDP-43 inclusions that ultimately cause RNA processing defects including dysregulation of splicing, mRNA transport and translation. Complementing our previous work in motor neurons, here we report a novel model of TDP-43 proteinopathy based on overexpression of TDP-43 in a subset of Drosophila Kenyon cells of the mushroom body (MB), a circuit with structural characteristics reminiscent of vertebrate cortical networks...
October 20, 2023: Acta Neuropathologica Communications
https://read.qxmd.com/read/37734947/rewarding-capacity-of-optogenetically-activating-a-giant-gabaergic-central-brain-interneuron-in-larval-drosophila
#8
JOURNAL ARTICLE
Nino Mancini, Juliane Thoener, Esmeralda Tafani, Dennis Pauls, Oded Mayseless, Martin Strauch, Katharina Eichler, Andrew Champion, Oliver Kobler, Denise Weber, Edanur Sen, Aliće Weiglein, Volker Hartenstein, Harrys Chytoudis, Tihana Jovanic, Andreas S Thum, Astrid Rohwedder, Michael Schleyer, Bertram Gerber
Larvae of the fruit fly Drosophila melanogaster are a powerful study case for understanding the neural circuits underlying behavior. Indeed, the numerical simplicity of the larval brain has permitted the reconstruction of its synaptic connectome, and genetic tools for manipulating single, identified neurons allow neural circuit function to be investigated with relative ease and precision. We focus on one of the most complex neurons in the brain of the larva (of either sex), the GABAergic anterior paired lateral neuron (APL)...
September 20, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37458578/circuits-underlying-social-function-and-dysfunction
#9
REVIEW
Ziwen Wang, Hannah Yueh, Mirabella Chau, Jeremy Veenstra-VanderWeele, Kally C O'Reilly
Substantial advances have been made toward understanding the genetic and environmental risk factors for autism, a neurodevelopmental disorder with social impairment as a core feature. In combination with optogenetic and chemogenetic tools to manipulate neural circuits in vivo, it is now possible to use model systems to test how specific neural circuits underlie social function and dysfunction. Here, we review the literature that has identified circuits associated with social interest (sociability), social reward, social memory, dominance, and aggression, and we outline a preliminary roadmap of the neural circuits driving these social behaviors...
July 17, 2023: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/37449488/negative-association-between-anterior-insula-activation-and-resilience-during-sustained-attention-an-fmri-twin-study
#10
JOURNAL ARTICLE
Arthur Montalto, Haeme R P Park, Leanne M Williams, Mayuresh S Korgaonkar, Miranda R Chilver, Javad Jamshidi, Peter R Schofield, Justine M Gatt
BACKGROUND: While previous studies have suggested that higher levels of cognitive performance may be related to greater wellbeing and resilience, little is known about the associations between neural circuits engaged by cognitive tasks and wellbeing and resilience, and whether genetics or environment contribute to these associations. METHODS: The current study consisted of 253 monozygotic and dizygotic adult twins, including a subsample of 187 early-life trauma-exposed twins, with functional Magnetic Resonance Imaging data from the TWIN-E study...
May 2023: Psychological Medicine
https://read.qxmd.com/read/37334059/bimodal-modulation-of-l1-interneuron-activity-in-anterior-cingulate-cortex-during-fear-conditioning
#11
JOURNAL ARTICLE
Giuliana Fossati, Daniel Kiss-Bodolay, Julien Prados, Ronan Chéreau, Elodie Husi, Christelle Cadilhac, Lucia Gomez, Bianca A Silva, Alexandre Dayer, Anthony Holtmaat
The anterior cingulate cortex (ACC) plays a crucial role in encoding, consolidating and retrieving memories related to emotionally salient experiences, such as aversive and rewarding events. Various studies have highlighted its importance for fear memory processing, but its circuit mechanisms are still poorly understood. Cortical layer 1 (L1) of the ACC might be a particularly important site of signal integration, since it is a major entry point for long-range inputs, which is tightly controlled by local inhibition...
2023: Frontiers in Neural Circuits
https://read.qxmd.com/read/37255663/automated-design-of-gene-circuits-with-optimal-mushroom-bifurcation-behavior
#12
JOURNAL ARTICLE
Irene Otero-Muras, Ruben Perez-Carrasco, Julio R Banga, Chris P Barnes
Recent advances in synthetic biology are enabling exciting technologies, including the next generation of biosensors, the rational design of cell memory, modulated synthetic cell differentiation, and generic multifunctional biocircuits. These novel applications require the design of gene circuits leading to sophisticated behaviors and functionalities. At the same time, designs need to be kept minimal to avoid compromising cell viability. Bifurcation theory addresses such challenges by associating circuit dynamical properties with molecular details of its design...
June 16, 2023: IScience
https://read.qxmd.com/read/37236919/the-genetic-architecture-of-fornix-white-matter-microstructure-and-their-involvement-in-neuropsychiatric-disorders
#13
JOURNAL ARTICLE
Ya-Nan Ou, Yi-Jun Ge, Bang-Sheng Wu, Yi Zhang, Yu-Chao Jiang, Kevin Kuo, Liu Yang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
The fornix is a white matter bundle located in the center of the hippocampaldiencephalic limbic circuit that controls memory and executive functions, yet its genetic architectures and involvement in brain disorders remain largely unknown. We carried out a genome-wide association analysis of 30,832 UK Biobank individuals of the six fornix diffusion magnetic resonance imaging (dMRI) traits. The post-GWAS analysis allowed us to identify causal genetic variants in phenotypes at the single nucleotide polymorphisms (SNP), locus, and gene levels, as well as genetic overlap with brain health-related traits...
May 26, 2023: Translational Psychiatry
https://read.qxmd.com/read/37214924/asymmetric-control-of-food-intake-by-left-and-right-vagal-sensory-neurons
#14
Alan Moreira de Araujo, Isadora Braga, Gabriel Leme, Arashdeep Singh, Molly McDougle, Justin Smith, Macarena Vergara, Mingxing Yang, M Lin, H Khoshbouei, Eric Krause, Andre G de Oliveira, Guillaume de Lartigue
UNLABELLED: We investigated the lateralization of gut-innervating vagal sensory neurons and their roles in feeding behavior. Using genetic, anatomical, and behavioral analyses, we discovered a subset of highly lateralized vagal sensory neurons with distinct sensory responses to intestinal stimuli. Our results demonstrated that left vagal sensory neurons (LNG) are crucial for distension-induced satiety, while right vagal sensory neurons (RNG) mediate preference for nutritive foods. Furthermore, these lateralized neurons engage different central circuits, with LNG neurons recruiting brain regions associated with energy balance and RNG neurons activating areas related to salience, memory, and reward...
May 8, 2023: bioRxiv
https://read.qxmd.com/read/37197830/functional-imaging-of-learning-induced-plasticity-in-the-central-nervous-system-with-genetically-encoded-reporters-in-drosophila
#15
JOURNAL ARTICLE
Tamara Boto, Seth M Tomchik
Learning and memory allow animals to adjust their behavior based on the predictive value of their past experiences. Memories often exist in complex representations, spread across numerous cells and synapses in the brain. Studying relatively simple forms of memory provides insights into the fundamental processes that underlie multiple forms of memory. Associative learning occurs when an animal learns the relationship between two previously unrelated sensory stimuli, such as when a hungry animal learns that a particular odor is followed by a tasty reward...
May 17, 2023: Cold Spring Harbor Protocols
https://read.qxmd.com/read/37117011/control-of-synaptic-levels-of-nicotinic-acetylcholine-receptor-by-the-sequestering-subunit-d%C3%AE-5-and-secreted-scaffold-protein-hig
#16
JOURNAL ARTICLE
Minoru Nakayama, Osamu Nishimura, Yuhi Nishimura, Miwa Kitaichi, Shigehiro Kuraku, Masaki Sone, Chihiro Hama
The presentation of nicotinic acetylcholine receptors (nAChRs) on synaptic membranes is crucial for generating cholinergic circuits, some of which are associated with memory function and neurodegenerative disorders. Although the physiology and structure of nAChR, a cation channel comprising five subunits, have been extensively studied, little is known about how the receptor levels in interneuronal synapses are determined and which nAChR subunits participate in the regulatory process in cooperation with synaptic cleft matrices and intracellular proteins...
April 27, 2023: Journal of Neuroscience
https://read.qxmd.com/read/37035621/reward-motivation-and-brain-imaging-in-human-healthy-participants-a-narrative-review
#17
REVIEW
Aviv M Weinstein
Over the past 20 years there has been an increasing number of brain imaging studies on the mechanisms underlying reward motivation in humans. This narrative review describes studies on the neural mechanisms associated with reward motivation and their relationships with cognitive function in healthy human participants. The brain's meso-limbic dopamine reward circuitry in humans is known to control reward-motivated behavior in humans. The medial and lateral Pre-Frontal Cortex (PFC) integrate motivation and cognitive control during decision-making and the dorsolateral PFC (dlPFC) integrates and transmits signals of reward to the mesolimbic and meso-cortical dopamine circuits and initiates motivated behavior...
2023: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/36809938/neurobehavioral-profiles-of-six-genetically-based-rat-models-of-schizophrenia-related-symptoms
#18
JOURNAL ARTICLE
Ignasi Oliveras, Toni Cañete, Daniel Sampedro-Viana, Cristóbal Río-Álamos, Adolf Tobeña, Maria G Corda, Osvaldo Giorgi, Alberto Fernández-Teruel
Schizophrenia is a chronic and severe mental disorder with high heterogeneity in its symptoms clusters. The effectiveness of drug treatments for the disorder is far from satisfactory. It is widely accepted that research with valid animal models is essential if we aim at understanding its genetic/neurobiological mechanisms and finding more effective treatments. The present article presents an overview of six genetically-based (selectively-bred) rat models/strains, which exhibit neurobehavioral schizophrenia- relevant features, i...
February 21, 2023: Current Neuropharmacology
https://read.qxmd.com/read/36807494/conditioned-place-avoidance-is-associated-with-a-distinct-hippocampal-phenotype-partly-preserved-pattern-separation-and-reduced-reactive-oxygen-species-production-after-stress
#19
JOURNAL ARTICLE
D Parker Kelley, Lucas Albrechet-Souza, Shealan Cruise, Rajani Maiya, Aspasia Destouni, Siva S V P Sakamuri, Alexander Duplooy, Meghan Hibicke, Charles Nichols, Prasad V G Katakam, Nicholas W Gilpin, Joseph Francis
Stress is associated with contextual memory deficits, which may mediate avoidance of trauma-associated contexts in posttraumatic stress disorder. These deficits may emerge from impaired pattern separation, the independent representation of similar experiences by the dentate gyrus-Cornu Ammonis 3 (DG-CA3) circuit of the dorsal hippocampus, which allows for appropriate behavioral responses to specific environmental stimuli. Neurogenesis in the DG is controlled by mitochondrial reactive oxygen species (ROS) production, and may contribute to pattern separation...
February 17, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/36750369/rapid-and-chronic-ethanol-tolerance-are-composed-of-distinct-memory-like-states-in-drosophila
#20
JOURNAL ARTICLE
Caleb Larnerd, Pratik Adhikari, Ashley Valdez, Alexander Del Toro, Fred W Wolf
Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced by ethanol intake, and yet its molecular and circuit bases remain largely unexplored. Here, we characterize three distinct forms of ethanol tolerance in male Drosophila: rapid, chronic, and repeated. Rapid tolerance is composed of two short-lived memory-like states, one that is labile and one that is consolidated. Chronic tolerance, induced by continuous exposure, lasts for two days, induces ethanol preference, and hinders the development of rapid tolerance through the activity of histone deacetylases (HDACs)...
February 7, 2023: Journal of Neuroscience
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