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https://www.readbyqxmd.com/read/29228522/factors-affecting-the-satisfaction-of-cancer-information-of-the-social-network-services-in-korea
#1
Su Yeon Kye, Min Hee Lee, Jisu Yoo, Kyounghee Oh, Jae Kwan Jun
Objectives: This study aims to identify the characteristics of social networking service (SNS) users and connect these factors to user satisfaction with the SNSs of the National Cancer Information Center (NCIC) in South Korea. Methods: A Web-based survey was completed by 1,670 users of the NCIC SNSs to collect data on sources for information on cancer, determinants for using the SNS, source of NCIC SNS awareness, time for use, and the satisfaction level of the users...
December 11, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29228002/comparative-cell-cycle-transcriptomics-reveals-synchronization-of-developmental-transcription-factor-networks-in-cancer-cells
#2
Johan Boström, Zuzana Sramkova, Alena Salašová, Helena Johard, Diana Mahdessian, Radek Fedr, Carolyn Marks, Jiřina Medalová, Karel Souček, Emma Lundberg, Sten Linnarsson, Vítězslav Bryja, Petra Sekyrova, Mikael Altun, Michael Andäng
The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and signalling pathways remains unclear. Here, we provide a resource consisting of mapped transcriptomes in unsynchronized HeLa and U2OS cancer cells sorted for cell cycle phase by Fucci reporter expression. We developed a novel algorithm for data analysis that enables efficient visualization and data comparisons and identified cell cycle synchronization of Notch signalling and TFs associated with development...
2017: PloS One
https://www.readbyqxmd.com/read/29227586/identification-of-potential-crucial-genes-associated-with-carcinogenesis-of-clear-cell-renal-cell-carcinoma
#3
Erlin Song, Wenting Song, Minghua Ren, Li Xing, Wenjun Ni, Yongxiang Li, Mancheng Gong, Mingbo Zhao, Xin Ma, Xu Zhang, Ruihua An
Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy with high mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective biomarkers for daily practice are still limited. Thus, we aimed to identify the potential crucial genes and pathways associated with carcinogenesis of ccRCC and further analyze the molecular mechanisms implicated in tumorigenesis. In the present study, expression profiles GSE 66270, GSE 53757, GSE 36895 and GSE 76351 were downloaded from GEO database, including 244 matched primary and adjacent normal tissues, furthermore, the level 3 RNAseq dataset (RNAseqV2 RSEM) of KIRC was also downloaded from The Cancer Genome Atlas (TCGA), which consist of 529 ccRCC tumors and 72 normal tissues...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227540/human-t-lymphotropic-virus-1-htlv-1-pathogenesis-a-systems-virology-study
#4
Sayed-Hamidreza Mozhgani, Mohadeseh Zarei Ghobadi, Majid Teymoori-Rad, Talat Mokhtari Azad, Mehdi Mirzaie, Mohsen Sheikhi, Seyed Mohammad Jazayeri, Ramin Shabahrami, Hedayatollah Ghourchian, Mohieddin Jafari, Seyed Abdolrahim Rezaee, Mehdi Norouzi
The main mechanisms of interaction between Human T-lymphotropic virus type 1 (HTLV-1) and its hosts in manifestation of related diseases including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T-cell leukemia/lymphoma (ATLL) are yet to be determined. It is pivotal to find out the changes in the genes expression toward an asymptomatic or symptomatic states. To this end, the systems virology analysis was performed. Firstly, the differentially expressed genes (DEGs) were taken pairwise among the four sample sets of Normal, Asymptomatic Carriers (ACs), ATLL, and HAM/TSP...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227351/impact-of-pectoral-nerve-block-on-postoperative-pain-and-quality-of-recovery-in-patients-undergoing-breast-cancer-surgery-a-randomised-controlled-trial
#5
Yoshinori Kamiya, Miki Hasegawa, Takayuki Yoshida, Misako Takamatsu, Yu Koyama
BACKGROUND: In recent years, thoracic wall nerve blocks, such as the pectoral nerve (PECS) block and the serratus plane block have become popular for peri-operative pain control in patients undergoing breast cancer surgery. The effect of PECS block on quality of recovery (QoR) after breast cancer surgery has not been evaluated. OBJECTIVES: To evaluate the ability of PECS block to decrease postoperative pain and anaesthesia and analgesia requirements and to improve postoperative QoR in patients undergoing breast cancer surgery...
December 8, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29226950/syndecans-in-chronic-inflammatory-and-autoimmune-diseases-pathological-insights-and-therapeutic-opportunities
#6
REVIEW
Solomon A Agere, Eugene Y Kim, Nahid Akhtar, Salahuddin Ahmed
Syndecans (SDCs) are a family of heparan sulfate proteoglycans (HSPGs) glycoproteins ubiquitously expressed on the cell surfaces and extracellular matrix of all mammalian tissues. There are four mammalian syndecans, SDC-1 thorough 4, which play a critical role in cell adhesion, migration, proliferation, differentiation, and angiogenesis through independent and growth factor mediated signaling. An altered expression of SDCs is often observed in autoimmune disorders, cancer, HIV infection, and many other pathological conditions...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226327/medication-use-and-kidney-cancer-survival-a-population-based-study
#7
Madhur Nayan, David N Juurlink, Peter C Austin, Erin M Macdonald, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
Several studies demonstrate that use of commonly-prescribed medications is associated with improved survival in various malignancies. Methods of classifying medication use in many of these studies, however, do not account for intermittent or cumulative use. Moreover, there are limited data in kidney cancer. Therefore, we performed a population-based cohort study utilizing healthcare databases in Ontario, Canada. We identified patients aged ≥65 with an incident diagnosis of kidney cancer between 1997-2013 and examined use of nine putative anti-neoplastic medications using prescription claims...
December 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29225696/colorectal-cancer-towards-new-challenges-and-concepts-of-preventive-healthcare
#8
EDITORIAL
Lidia Colace, Stefania Boccia, Ruggero De Maria, Ann Zeuner
Colorectal cancer (CRC) holds the woeful record of being the most preventable but least prevented type of cancer. Although healthy lifestyles and screening programs associated to early polyp removal greatly reduce CRC incidence and CRC-related death, the overall lack of information and of effective preventive policies is promoting an overwhelming global escalation of this disease. Moreover, new challenges such as the increasing occurrence of aggressive CRC in young adults highlight underlying changes not only in the incidence but also in the nature of this disease...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29225579/regulation-of-tissue-growth-by-the-mammalian-hippo-signaling-pathway
#9
REVIEW
Kevin I Watt, Kieran F Harvey, Paul Gregorevic
The integrative control of diverse biological processes such as proliferation, differentiation, apoptosis and metabolism is essential to maintain cellular and tissue homeostasis. Disruption of these underlie the development of many disease states including cancer and diabetes, as well as many of the complications that arise as a consequence of aging. These biological outputs are governed by many cellular signaling networks that function independently, and in concert, to convert changes in hormonal, mechanical and metabolic stimuli into alterations in gene expression...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29224918/the-regulatory-network-behind-mhc-class-i-expression
#10
Marlieke L M Jongsma, Greta Guarda, Robbert M Spaapen
The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is hijacked in many pathological conditions. This affects MHC class I levels and peptide presentation at the cell surface leading to immune escape of cancer cells or microbes. It is therefore important to identify the molecular mechanisms behind MHC class I expression, processing and antigen presentation. The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism involved...
December 7, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29224830/a-network-meta-analysis-in-comparing-prophylactic-treatments-of-radiotherapy-induced-oral-mucositis-for-patients-with-head-and-neck-cancers-receiving-radiotherapy
#11
Hao Peng, Bin-Bin Chen, Lei Chen, Yu-Pei Chen, Xu Liu, Ling-Long Tang, Yan-Ping Mao, Wen-Fei Li, Yuan Zhang, Ai-Hua Lin, Ying Sun, Jun Ma
OBJECTIVES: The objective of this network meta-analysis is to optimize the prophylactic treatment for radiotherapy-induced oral mucositis in patients with head and neck cancer (HNSCC) receiving postoperative or definitive radiotherapy with or without chemotherapy. MATERIALS AND METHODS: We searched electronic databases to identify all eligible randomized clinical trials on oral mucositis. The endpoint was grade 0-2 oral mucositis. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were extracted...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29222421/the-transcriptomic-signature-of-disease-development-and-progression-of-nonalcoholic-fatty-liver-disease
#12
Sophie Cazanave, Alexei Podtelezhnikov, Kristian Jensen, Mulugeta Seneshaw, Divya P Kumar, Hae-Ki Min, Prasanna K Santhekadur, Bubu Banini, Adolfo Gabriele Mauro, Abdul M Oseini, Robert Vincent, Keith Q Tanis, Andrea L Webber, Liangsu Wang, Pierre Bedossa, Faridoddin Mirshahi, Arun J Sanyal
A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease. The hepatic transcriptome of such mice with fatty liver (8 weeks), steatohepatitis with early fibrosis (16-24 weeks) and advanced fibrosis (52 weeks) after initiation of the diet was evaluated and compared to mice on chow diet...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221754/up-regulation-of-ypel1-and-ypel5-and-down-regulation-of-itga2-in-erlotinib-treated-egfr-mutant-non-small-cell-lung-cancer-a-bioinformatic-analysis
#13
Xiaoli Wu
PURPOSE: This study aimed to identify genes with significant alteration following treatment of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors (TKIs). METHODS: We downloaded microarray data of GSE67051 from the Gene Expression Omnibus (GEO) database. Genes with differential expression were identified in two groups: erlotinib-treated versus DMSO-treated PC9 cells and erlotinib-treated versus DMSO-treated HCC827 cells...
December 5, 2017: Gene
https://www.readbyqxmd.com/read/29221719/integration-of-different-criteria-for-borderline-resectable-pancreatic-cancer-using-classification-tree-analysis-the-use-of-radiological-tumour-vascular-interface-in-correlation-with-surgical-and-pathological-outcomes
#14
J A Hwang, K M Jang, S H Kim, T W Kang, K D Song, D I Cha, S Ahn
AIM: To integrate various criteria for borderline resectable pancreatic cancer (BRPC) based on radiological parameters using classification tree analysis. MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived the requirement for informed consent. Two hundred and thirty-five tumour-vein interfaces and 67 tumour-artery interfaces in 245 patients with surgically confirmed pancreatic ductal adenocarcinoma who underwent both preoperative computed tomography (CT) and magnetic resonance imaging (MRI) were assessed by two independent readers...
December 5, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29221209/direct-hpv-e6-myc-interactions-induce-histone-modifications-pol-ii-phosphorylation-and-htert-promoter-activation
#15
Yiyu Zhang, Aleksandra Dakic, Renxiang Chen, Yuhai Dai, Richard Schlegel, Xuefeng Liu
Human Papillomavirus Viruses (HPVs) are associated with the majority of human cervical and anal cancers and 10-30% of head and neck squamous carcinomas. E6 oncoprotein from high risk HPVs interacts with the p53 tumor suppressor protein to facilitate its degradation and increases telomerase activity for extending the life span of host cells. We published previously that the Myc cellular transcription factor associates with the high-risk HPV E6 protein in vivo and participates in the transactivation of the hTERT promoter...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221160/circular-rna-profile-indicates-circular-rna-vrk1-is-negatively-related-with-breast-cancer-stem-cells
#16
Ningning Yan, Haiyan Xu, Jinnan Zhang, Liang Xu, Yanyun Zhang, Le Zhang, Yingchun Xu, Fengchun Zhang
Circular RNAs (circRNAs), a novel type of noncoding RNAs (ncRNAs), have been shown to be implicated in biological processes including cancer as gene expression regulators. However, the roles of circRNAs in cancer stem cells (CSCs) have been unexplored. In the present study, we screened the circRNA profile in breast cancer stem cells (BCSCs) using RNA-Sequencing. Here, 27 circRNAs were found to be aberrantly expressed. Of these, 19 circRNAs were downregulated and 8 were upregulated and some of these circRNAs were validated by Q-PCR...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220450/ctd2-dashboard-a-searchable-web-interface-to-connect-validated-results-from-the-cancer-target-discovery-and-development-network
#17
Bülent Arman Aksoy, Vlado Dancík, Kenneth Smith, Jessica N Mazerik, Zhou Ji, Benjamin Gross, Olga Nikolova, Nadia Jaber, Andrea Califano, Stuart L Schreiber, Daniela S Gerhard, Leandro C Hermida, Subhashini Jagu, Chris Sander, Aris Floratos, Paul A Clemons
https://ctd2-dashboard.nci.nih.gov/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29220078/using-the-seven-bridges-cancer-genomics-cloud-to-access-and-analyze-petabytes-of-cancer-data
#18
Raunaq Malhotra, Isheeta Seth, Erik Lehnert, Jing Zhao, Gaurav Kaushik, Elizabeth H Williams, Anurag Sethi, Brandi N Davis-Dusenbery
Next-generation sequencing has produced petabytes of data, but accessing and analyzing these data remain challenging. Traditionally, researchers investigating public datasets like The Cancer Genome Atlas (TCGA) would download the data to a high-performance cluster, which could take several weeks even with a highly optimized network connection. The National Cancer Institute (NCI) initiated the Cancer Genomics Cloud Pilots program to provide researchers with the resources to process data with cloud computational resources...
December 8, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/29220067/gene-expression-and-fatigue-in-puerto-rican-men-during-radiotherapy-for-prostate-cancer-an-exploratory-study
#19
Velda J Gonzalez, Leorey N Saligan, Brooke L Fridley, Humberto Ortiz-Zuazaga, Lauren S Aaronson
OBJECTIVE: To examine the trajectory of fatigue experienced by 26 Puerto Rican (PR) men over the course of External Beam Radiation Therapy (EBRT) and to assess gene expression changes from baseline to midpoint of EBRT using microarray technology. Design/Research Approach- Prospective exploratory and comparative design study. Setting- RT facility located in San Juan, PR. Sample/Participants-26 PR men with non-metastatic prostate cancer. METHODS: Participants completed 2 paper forms: demographics and the Spanish version of the 13-item FACT-fatigue at baseline, midpoint, and end of EBRT...
December 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29220064/importance-of-and-satisfaction-with-psychosocial-support-among-cancer-patients-and-survivors-in-puerto-rico-gender-health-status-and-quality-of-life-associations
#20
Eida M Castro, Gloria Asencio, Gwendolyn P Quinn, Thomas Brandon, Clement K Gwede, Susan Vadaparampil, Vani Simmons, Jessica McIntyre, Julio Jiménez
OBJECTIVE: To assess needs perceptions regarding the importance of and satisfaction with psychosocial support among cancer patients and survivors in Puerto Rico. METHODS: A cross-sectional study was conducted in 181 participants (70 men and 111 women) who were either undergoing cancer treatment (patients) or had completed cancer treatment (survivors). Participants completed a sociodemographic and clinical characteristics questionnaire, and the Psychosocial Needs Inventory (PNI)...
December 2017: Puerto Rico Health Sciences Journal
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