keyword
MENU ▼
Read by QxMD icon Read
search

Stochastic

keyword
https://www.readbyqxmd.com/read/28222265/modeling-soluble-and-particulate-lead-release-into-drinking-water-from-full-and-partially-replaced-lead-service-lines
#1
Ahmed A Abokifa, Pratim Biswas
Partial replacement of lead service lines (LSLs) often results in the excessive long-term release of lead particulates due to the disturbance of pipe scale and galvanic corrosion. In this study, a modeling approach to simulate the release and transport of particulate and dissolved lead from full and partially replaced LSLs is developed. A mass transfer model is coupled with a stochastic residential water demand generator to investigate the effect of normal household usage (NHU) flow patterns on lead exposure...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28222198/algorithmic-design-of-a-noise-resistant-and-efficient-closed-loop-deep-brain-stimulation-system-a-computational-approach
#2
Sofia D Karamintziou, Ana Luísa Custódio, Brigitte Piallat, Mircea Polosan, Stéphan Chabardès, Pantelis G Stathis, George A Tagaris, Damianos E Sakas, Georgia E Polychronaki, George L Tsirogiannis, Olivier David, Konstantina S Nikita
Advances in the field of closed-loop neuromodulation call for analysis and modeling approaches capable of confronting challenges related to the complex neuronal response to stimulation and the presence of strong internal and measurement noise in neural recordings. Here we elaborate on the algorithmic aspects of a noise-resistant closed-loop subthalamic nucleus deep brain stimulation system for advanced Parkinson's disease and treatment-refractory obsessive-compulsive disorder, ensuring remarkable performance in terms of both efficiency and selectivity of stimulation, as well as in terms of computational speed...
2017: PloS One
https://www.readbyqxmd.com/read/28221833/evolution-of-thermal-reaction-norms-in-seasonally-varying-environments
#3
Priyanga Amarasekare, Christopher Johnson
Thermal reaction norms of ectotherms exhibit a distinctive latitudinal pattern: the temperature at which performance is maximized coincides with the mean habitat temperature in tropical ectotherms but exceeds the mean temperature in temperate ectotherms. We hypothesize, on the basis of Jensen's inequality, that this pattern is driven by latitudinal variation in seasonal temperature fluctuations. We test this hypothesis with an eco-evolutionary model that integrates the quantitative genetics of reaction norm evolution with stage-structured population dynamics, which we parameterize with data from insects...
March 2017: American Naturalist
https://www.readbyqxmd.com/read/28220061/a-model-of-induction-of-cerebellar-long-term-depression-including-rkip-inactivation-of-raf-and-mek
#4
Iain Hepburn, Anant Jain, Himanshu Gangal, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Erik De Schutter
We report an updated stochastic model of cerebellar Long Term Depression (LTD) with improved realism. Firstly, we verify experimentally that dissociation of Raf kinase inhibitor protein (RKIP) from Mitogen-activated protein kinase kinase (MEK) is required for cerebellar LTD and add this interaction to an earlier published model, along with the known requirement of dissociation of RKIP from Raf kinase. We update Ca(2+) dynamics as a constant-rate influx, which captures experimental input profiles accurately...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28219972/venomics-integrative-venom-proteomics-and-beyond
#5
REVIEW
Juan J Calvete
Venoms are integrated phenotypes that evolved independently in, and are used for predatory and defensive purposes by, a wide phylogenetic range of organisms. The same principles that contribute to the evolutionary success of venoms, contribute to making the study of venoms of great interest in such diverse fields as evolutionary ecology and biotechnology. Evolution is profoundly contingent, and nature also reinvents itself continuosly. Changes in a complex phenotypic trait, such as venom, reflect the influences of prior evolutionary history, chance events, and selection...
February 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28219776/deactivation-in-the-posterior-mid-cingulate-cortex-reflects-perceptual-transitions-during-binocular-rivalry-evidence-from-simultaneous-eeg-fmri
#6
Abhrajeet Roy, Keith Jamison, Sheng He, Steve Engel, Bin He
Binocular rivalry is a phenomenon in which perception spontaneously shifts between two different images that are dichoptically presented to the viewer. By elucidating the cortical networks responsible for these stochastic fluctuations in perception, we can potentially learn much about the neural correlates of visual awareness. We obtained concurrent EEG-fMRI data for a group of 20 healthy human subjects during the continuous presentation of dichoptic visual stimuli. The two eyes' images were tagged with different temporal frequencies so that eye specific steady-state visual evoked potential (SSVEP) signals could be extracted from the EEG data for direct comparison with changes in fMRI BOLD activity associated with binocular rivalry...
February 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28219439/rnas-competing-for-micrornas-mutually-influence-their-fluctuations-in-a-highly-non-linear-microrna-dependent-manner-in-single-cells
#7
Carla Bosia, Francesco Sgrò, Laura Conti, Carlo Baldassi, Davide Brusa, Federica Cavallo, Ferdinando Di Cunto, Emilia Turco, Andrea Pagnani, Riccardo Zecchina
BACKGROUND: Distinct RNA species may compete for binding to microRNAs (miRNAs). This competition creates an indirect interaction between miRNA targets, which behave as miRNA sponges and eventually influence each other's expression levels. Theoretical predictions suggest that not only the mean expression levels of targets but also the fluctuations around the means are coupled through miRNAs. This may result in striking effects on a broad range of cellular processes, such as cell differentiation and proliferation...
February 20, 2017: Genome Biology
https://www.readbyqxmd.com/read/28219373/a-new-efficient-approach-to-fit-stochastic-models-on-the-basis-of-high-throughput-experimental-data-using-a-model-of-irf7-gene-expression-as-case-study
#8
Luis U Aguilera, Christoph Zimmer, Ursula Kummer
BACKGROUND: Mathematical models are used to gain an integrative understanding of biochemical processes and networks. Commonly the models are based on deterministic ordinary differential equations. When molecular counts are low, stochastic formalisms like Monte Carlo simulations are more appropriate and well established. However, compared to the wealth of computational methods used to fit and analyze deterministic models, there is only little available to quantify the exactness of the fit of stochastic models compared to experimental data or to analyze different aspects of the modeling results...
February 20, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28218920/a-non-volatile-organic-electrochemical-device-as-a-low-voltage-artificial-synapse-for-neuromorphic-computing
#9
Yoeri van de Burgt, Ewout Lubberman, Elliot J Fuller, Scott T Keene, Grégorio C Faria, Sapan Agarwal, Matthew J Marinella, A Alec Talin, Alberto Salleo
The brain is capable of massively parallel information processing while consuming only ∼1-100 fJ per synaptic event. Inspired by the efficiency of the brain, CMOS-based neural architectures and memristors are being developed for pattern recognition and machine learning. However, the volatility, design complexity and high supply voltages for CMOS architectures, and the stochastic and energy-costly switching of memristors complicate the path to achieve the interconnectivity, information density, and energy efficiency of the brain using either approach...
February 20, 2017: Nature Materials
https://www.readbyqxmd.com/read/28217990/telomerase-activity-detection-with-amplification-free-single-molecule-stochastic-binding-assay
#10
Xin Su, Zehao Li, Xinzhong Yan, Lei Wang, Xu Zhou, Lin Wei, Lehui Xiao, Changyuan Yu
Since the elongation of telomeres is associated with tumorigenesis, it is of great interest to develop rapid and high-confidence telomerase activity detection methods for disease diagnosis. Currently, amplification based strategies have been extensively explored for telomerase detection in vitro and in vivo. However, amplification typically associated with poor reproducibility and high background which hamper their further applications particularly for real sample assay. Here, we demonstrated a new amplification-free single molecule imaging method for telomerase activity detection in vitro based on nucleic acid stochastic binding with total internal reflection fluorescence microscopy (TIRFM)...
February 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28217934/population-dynamics-of-wild-rodents-induce-stochastic-fadeouts-of-a-zoonotic-pathogen
#11
Giorgio Guzzetta, Valentina Tagliapietra, Sarah E Perkins, Heidi C Hauffe, Piero Poletti, Stefano Merler, Annapaola Rizzoli
Stochastic processes play an important role in the infectious disease dynamics of wildlife, especially in species subject to large population oscillations. Here we study the case of a free ranging population of yellow-necked mice (Apodemus flavicollis) in northern Italy, where circulation of Dobrava-Belgrade hantavirus (DOBV) has been detected intermittently since 2001, until an outbreak emerged in 2010. We analyzed the transmission dynamics of the recent outbreak using a computational model that accounts for seasonal changes of the host population and territorial behavior...
February 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28217106/effect-of-noisy-galvanic-vestibular-stimulation-on-ocular-vestibular-evoked-myogenic-potentials-to-bone-conducted-vibration
#12
Shinichi Iwasaki, Shotaro Karino, Teru Kamogashira, Fumiharu Togo, Chisato Fujimoto, Yoshiharu Yamamoto, Tatsuya Yamasoba
OBJECTIVE: Galvanic vestibular stimulation (GVS) delivered as zero-mean current noise (noisy GVS) has been shown to improve static and dynamic postural stability probably by enhancing vestibular information. The purpose of this study was to examine the effect of an imperceptible level noisy GVS on ocular vestibular-evoked myogenic potentials (oVEMPs) in response to bone-conducted vibration (BCV). MATERIALS AND METHODS: oVEMPs to BCV were measured during the application of white noise GVS with an amplitude ranging from 0 to 300 µA [in root mean square (RMS)] in 20 healthy subjects...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28216235/finite-time-stability-and-stabilization-for-stochastic-markov-jump-systems-with-mode-dependent-time-delays
#13
Zhiguo Yan, Yunxia Song, Ju H Park
This paper is concerned with the problems of finite-time stability and stabilization for stochastic Markov systems with mode-dependent time-delays. In order to reduce conservatism, a mode-dependent approach is utilized. Based on the derived stability conditions, state-feedback controller and observer-based controller are designed, respectively. A new N-mode algorithm is given to obtain the maximum value of time-delay. Finally, an example is used to show the merit of the proposed results.
February 16, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28215939/live-imaging-analysis-of-germ-cell-proliferation-in-the-c-elegans-adult-supports-a-stochastic-model-for-stem-cell-proliferation
#14
Simona Rosu, Orna Cohen-Fix
The C. elegans adult hermaphrodite contains a renewable pool of mitotically dividing germ cells that are contained within the progenitor zone (PZ), at the distal region of the germline. From the PZ, cells enter meiosis and differentiate, ensuring the continued production of oocytes. In this study, we investigated the proliferation strategy used to maintain the PZ pool by using a photoconvertible marker to follow the fate of selected germ cells and their descendants in live worms. We found that the most distal pool of 6-8 rows of cells in the PZ (the distal third) behave similarly, with a fold expansion corresponding to one cell division every 6hours on average...
February 16, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28215806/introducing-the-2-drops-model-for-two-dimensional-simulation-of-crop-roots-and-pesticide-within-the-soil-root-zone
#15
Annika Agatz, Colin D Brown
Mathematical models of pesticide fate and behaviour in soils have been developed over the last 30years. Most models simulate fate of pesticides in a 1-dimensional system successfully, supporting a range of applications where the prediction target is either bulk residues in soil or receiving compartments outside of the soil zone. Nevertheless, it has been argued that the 1-dimensional approach is limiting the application of knowledge on pesticide fate under specific pesticide placement strategies, such as seed, furrow and band applications to control pests and weeds...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28214862/differential-clonal-expansion-in-an-invading-cell-population-clonal-advantage-or-dumb-luck
#16
Donald F Newgreen, Dongcheng Zhang, Bevan L Cheeseman, Benjamin J Binder, Kerry A Landman
In neoplastic cell growth, clones and subclones are variable both in size and mutational spectrum. The largest of these clones are believed to represent those cells with mutations that make them the most "fit," in a Darwinian sense, for expansion in their microenvironment. Thus, the degree of quantitative clonal expansion is regarded as being determined by innate qualitative differences between the cells that originate each clone. Here, using a combination of mathematical modelling and clonal labelling experiments applied to the developmental model system of the forming enteric nervous system, we describe how cells which are qualitatively identical may consistently produce clones of dramatically different sizes: most clones are very small while a few clones we term "superstars" contribute most of the cells to the final population...
2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28212667/assessing-the-interruption-of-the-transmission-of-human-helminths-with-mass-drug-administration-alone-optimizing-the-design-of-cluster-randomized-trials
#17
Roy Anderson, Sam Farrell, Hugo Turner, Judd Walson, Christl A Donnelly, James Truscott
BACKGROUND: A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is employed in attempts to eliminate the transmission of soil-transmitted helminths (STH) in defined geographic locations. The hypothesis to be tested is: Can MDA alone interrupt the transmission of STH species in defined settings? Clustering is at a village level and the choice of clusters of villages is stratified by transmission intensity (low, medium and high) and parasite species mix (either Ascaris, Trichuris or hookworm dominant)...
February 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28212112/cancer-as-robust-intrinsic-state-shaped-by-evolution-a-key-issues-review
#18
Ruoshi Yuan, Xiaomei Zhu, Gaowei Wang, Site Li, Ping Ao
Cancer is a complex disease: its pathology cannot be properly understood in terms of independent players-genes, proteins, molecular pathways, or their simple combinations. This is similar to many-body physics of a condensed phase that many important properties are not determined by a single atom or molecule. The rapidly accumulating large 'omics' data also require a new mechanistic and global underpinning to organize for rationalizing cancer complexity. A unifying and quantitative theory was proposed by some of the present authors that cancer is a robust state formed by the endogenous molecular-cellular network, which is evolutionarily built for the developmental processes and physiological functions...
February 17, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28212094/characteristics-of-myosin-v-processivity
#19
Jun-Ping Zhang, Yi Liu, Wei Sun, Xiaoyang Zhao, Ta La, Wei-Sheng Guo
Myosin V is a processive doubled-headed biomolecular motor involved in many intracellular organelle and vesicle transport. The unidirectional movement is coupled with the adenosine triphosphate (ATP) hydrolysis and product release cycle. With the progress of experimental techniques and the enhancement of measuring directness, detailed knowledge of the motility of myosin V has been obtained.Following the ATPase cycle, the 4-state mechanochemical model of the myosin V's processive movement is used. The transitions between various states take place in a stochastic manner...
February 14, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28212087/dual-deep-network-for-visual-tracking
#20
Zhizhen Chi, Hongyang Li, Huchuan Lu, Minghsuan Yang
Visual tracking addresses the problem of identifying and localizing an unknown target in a video given the target specified by a bounding box in the first frame. In this paper, we propose a dual network to better utilize features among layers for visual tracking. It is observed that features in higher layers encode semantic context while its counterparts in lower layers are sensitive to discriminative appearance. Thus we exploit the hierarchical features in different layers of a deep model and design a dual structure to obtain better feature representation from various streams, which is rarely investigated in previous work...
February 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
keyword
keyword
14339
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"