keyword
https://read.qxmd.com/read/38537153/novel-proteomic-signatures-may-indicate-mri-assessed-intrahepatic-fat-state-and-changes-the-direct-plus-clinical-trial
#1
JOURNAL ARTICLE
Dana T Goldberg, Anat Yaskolka Meir, Gal Tsaban, Ehud Rinott, Alon Kaplan, Hila Zelicha, Nora Klöting, Uta Ceglarek, Berend Iserman, Ilan Shelef, Philip Rosen, Matthias Blüher, Michael Stumvoll, Ohad Etzion, Meir J Stampfer, Frank B Hu, Iris Shai
OBJECTIVE: We demonstrated in the randomized 18-month DIRECT PLUS trial (n=294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with two other healthy diets, reducing NAFLD by half, regardless similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536017/effects-of-empagliflozin-on-liver-fat-in-metabolic-dysfunction-associated-steatotic-liver-disease-patients-without-diabetes-mellitus-a-randomized-double-blind-placebo-controlled-trial
#2
JOURNAL ARTICLE
Ka Shing Cheung, Ho Yu Ng, Rex Wan Hin Hui, Lok Ka Lam, Lung Yi Mak, Yuen Chi Ho, Jing Tong Tan, Esther W Chan, Wai Kay Seto, Man Fung Yuen, Wai K Leung
BACKGROUND AND AIMS: We investigated whether empagliflozin reduces hepatic steatosis in metabolic-dysfunction associated steatotic liver disease (MASLD) patients without diabetes mellitus (DM). APPROACH AND RESULTS: This was an investigator-initiated, double-blind, randomized, placebo-controlled trial recruiting adult subjects from the community. Eligible subjects without DM (fasting plasma glucose <7 mmol/L and HbA1c <6.5%) who had magnetic resonance imaging-proton density fat fraction [MRI-PDFF] ≥5% were randomly allocated to receive empagliflozin 10 mg daily or placebo (1:1 ratio) for 52 weeks (end of treatment, EOT)...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38534511/emerging-trends-in-magnetic-resonance-fingerprinting-for-quantitative-biomedical-imaging-applications-a-review
#3
REVIEW
Anmol Monga, Dilbag Singh, Hector L de Moura, Xiaoxia Zhang, Marcelo V W Zibetti, Ravinder R Regatte
Magnetic resonance imaging (MRI) stands as a vital medical imaging technique, renowned for its ability to offer high-resolution images of the human body with remarkable soft-tissue contrast. This enables healthcare professionals to gain valuable insights into various aspects of the human body, including morphology, structural integrity, and physiological processes. Quantitative imaging provides compositional measurements of the human body, but, currently, either it takes a long scan time or is limited to low spatial resolutions...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38531539/patient-satisfaction-with-ultrasound-whole-body-ct-and-whole-body-diffusion-weighted-mri-for-pre-operative-ovarian-cancer-staging-a-multicenter-prospective-cross-sectional-survey
#4
JOURNAL ARTICLE
Patrícia Pinto, Lil Valentin, Martina Borčinová, Markéta Wiesnerová, Fruhauf Filip, Andrea Burgetova, Martin Masek, Lukas Lambert, Valentina Chiappa, Dorella Franchi, Antonia Carla Testa, Francesca Moro, Giacomo Avesani, Camilla Panico, Sarah Alessi, Paola Pricolo, Raffaella Vigorito, Giuseppina Calareso, Roman Kocian, Jiri Slama, Anna Fagotti, Ailyn Mariela Vidal Urbinati, Mauro Signorelli, Francesca Bertolina, David Cibula, Daniela Fischerova
BACKGROUND: In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. OBJECTIVE: To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients' experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) for pre-operative ovarian cancer work-up...
March 26, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38516546/doxycycline-induced-intracranial-hypertension-presenting-as-unilateral-pulsatile-tinnitus
#5
JOURNAL ARTICLE
Naushin Shabnam Ali, Barry Daniel Long, Nauman F Manzoor, Aristides Sismanis, Daniel H Coelho
BACKGROUND: Pulsatile tinnitus (PT) is increasingly recognized as a cardinal symptom of idiopathic intracranial hypertension (IIH). However, clinicians should remain aware of other causes of nonidiopathic or secondary intracranial hypertension manifesting as PT. We present 2 patients with isolated PT (without accompanying headache, blurred vision, and papilledema) thought to be secondary to tetracycline-induced intracranial hypertension. To our knowledge, these are the first cases of PT as the presenting symptom of this condition...
December 2023: Otol Neurotol Open
https://read.qxmd.com/read/38515603/effect-of-age-and-body-mass-index-on-time-to-advanced-imaging-and-surgery-in-young-athletes-with-anterior-cruciate-ligament-injury
#6
JOURNAL ARTICLE
Joseph M Sliepka, Jonathon Gatto, Ananth Iyer, Michael Saper, Gregory Schmale, Albert Gee, Christopher Kweon, Kenneth Chin, Mia Hagen
BACKGROUND: In young athletes with anterior cruciate ligament (ACL) injury, increased times from injury to magnetic resonance imaging (MRI) and injury to surgery can lead to the accrual of new injuries over time. PURPOSE: To determine the patient characteristics associated with differences in timing between injury, MRI, and surgery in young athletes with ACL tears. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: We reviewed the electronic medical records of patients aged 13 to 25 years who underwent isolated primary ACL reconstruction between January 2017 and June 2020 at a single orthopaedic surgery department...
March 2024: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/38514344/-effectiveness-of-minimally-invasive-surgery-in-the-treatment-of-pancreatic-acinar-cell-carcinoma
#7
JOURNAL ARTICLE
M Tao, C H Yuan, C L Ma, B Jiang, L Li, H Y Wang, D R Xiu
Objective: To explore the effectiveness of minimally invasive surgical treatment for pancreatic acinar cell carcinoma (PACC). Methods: Six patients with PACC diagnosed in Peking University Third Hospital from January 2010 to September 2022 were retrospectively selected. Preoperative evaluation was performed on whether the lesions were eligible for surgery, including whether radical resection of liver metastases could be performed. Laparoscopic or Da Vinci robot-assisted resection was performed on six patients, and spleen retention was determined according to the original lesions and the relationship with peripheral blood vessels and tissues, while simultaneous resection was performed on cases of peripheral organ tissue invasion...
March 26, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38510210/linking-sarcopenia-brain-structure-and-cognitive-performance-a-large-scale-uk-biobank-study
#8
JOURNAL ARTICLE
Tiril P Gurholt, Miguel Germán Borda, Nadine Parker, Vera Fominykh, Rikka Kjelkenes, Jennifer Linge, Dennis van der Meer, Ida E Sønderby, Gustavo Duque, Lars T Westlye, Dag Aarsland, Ole A Andreassen
Sarcopenia refers to age-related loss of muscle mass and function and is related to impaired somatic and brain health, including cognitive decline and Alzheimer's disease. However, the relationships between sarcopenia, brain structure and cognition are poorly understood. Here, we investigate the associations between sarcopenic traits, brain structure and cognitive performance. We included 33 709 UK Biobank participants (54.2% female; age range 44-82 years) with structural and diffusion magnetic resonance imaging, thigh muscle fat infiltration ( n = 30 561) from whole-body magnetic resonance imaging (muscle quality indicator) and general cognitive performance as indicated by the first principal component of a principal component analysis across multiple cognitive tests ( n = 22 530)...
2024: Brain communications
https://read.qxmd.com/read/38507641/gerstmann-syndrome-case-control-study-correlation-between-brain-lesions-functional-disability
#9
JOURNAL ARTICLE
Abdulnaser Abdulqader Salih Al-Samaraie
Deep functional and structural neuroimaging of a series of Gerstmann's syndrome patients required high accuracy, and our results avoided false overlaps of heterogeneous brain lesions by handling each case of our study subjects separately as an individual case regarding functional and neuroimaging tests. Six patients with Gerstmann tetrad (one with dominant acalculia, one with dominant left and right disorientation, two with writing disabilities and two with finger agnosia) and 6 control subjects with close ages were recruited in the current study...
March 18, 2024: International Tinnitus Journal
https://read.qxmd.com/read/38506233/distal-femoral-stress-fractures-has-high-operation-rates-in-adolescent-and-young-adult-athletes
#10
JOURNAL ARTICLE
Mikalyn T DeFoor, Edmund P Mullin, Rachel A Cuenca, Sarah N Pierrie
BACKGROUND: Although stress fractures of the distal femur are rare, symptoms can overlap with other peri-articular knee pathology, delaying diagnosis. Untreated stress fractures have the potential to progress into completed fractures with a higher likelihood for requiring surgery and longer recovery times in otherwise healthy adolescents and young adults. This case series represents the largest cohort of adolescent athletes with distal femoral stress fractures who presented with activity-related knee pain...
March 20, 2024: Journal of Pediatric Orthopedics
https://read.qxmd.com/read/38499270/cmr-reference-values-of-right-ventricular-volumetric-variables-in-patients-with-hypoplastic-left-heart-syndrome
#11
JOURNAL ARTICLE
Andrik Ballenberger, Amke Caliebe, Sylvia Krupickova, Anselm Uebing, Dominik Daniel Gabbert, Inga Voges
BACKGROUND: Cardiovascular magnetic resonance (CMR) has established itself as the gold standard for serial assessment of systemic right ventricular (RV) performance but due to the lack of standardized RV reference values for HLHS patients, the interpretation of RV volumetric data in HLHS remains difficult. Therefore, this study aimed to close this gap by providing CMR reference values for the systemic RV in HLHS patients. METHODS: CMR scans of 160 children, adolescents and young adults (age range 2...
March 16, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38499253/simultaneous-focal-boost-with-stereotactic-radiotherapy-for-localised-intermediate-to-high-risk-prostate-cancer-primary-outcomes-of-the-sparc-phase-ii-trial
#12
JOURNAL ARTICLE
Binnaz Yasar, Yae-Eun Suh, Ewan Chapman, Luke Nicholls, Daniel Henderson, Caroline Jones, Kirsty Morrison, Emma Wells, Julia Henderson, Carole Meehan, Aslam Sohaib, Helen Taylor, Alison Tree, Nicholas Van As
PURPOSE: Dose escalated radiotherapy is associated with better biochemical control at the expense of toxicity. Stereotactic body radiotherapy (SBRT) with dose escalation to the dominant intraprostatic lesion (DIL) provides a logical approach to improve outcomes in high-risk disease whilst limiting toxicity. This study evaluated the toxicity and quality of life (QOL) with CyberKnife-based SBRT and simultaneous integrated boost in localised prostate cancer. METHODS AND MATERIALS: Eligible participants included newly diagnosed, biopsy-proven unfavourable intermediate to high risk localised prostate cancer (at least one of the following: Gleason ≥ 4+3, MRI defined T3a N0, PSA ≥ 20) with up to two MRI-identified DILs...
March 16, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38499113/pharmacokinetics-safety-and-tolerability-of-the-novel-tetrameric-gadolinium-based-mri-contrast-agent-gadoquatrane-in-healthy-chinese-and-japanese-men-two-randomized-dose-escalation-studies-including-concentration-qtc-modeling
#13
JOURNAL ARTICLE
Xuemei He, Shunji Matsuki, Kexin Li, Yubin Sui, Kumi Matsuno, Mengyuan Ren, Gabriele Sutter, Birte Maria Hofmann
PURPOSE: To investigate the pharmacokinetics, safety, and tolerability of the novel tetrameric high-relaxivity gadolinium-based contrast agent gadoquatrane in Japanese (Study 1) and Chinese men (Study 2). PARTICIPANTS AND METHODS: In two similarly designed single-center, randomized, single-blind, placebo-controlled, consecutive-cohort dose-escalation studies, healthy volunteers were randomly assigned to intravenous administration of gadoquatrane (0.01-0.1 mmol gadolinium/kg body weight) or placebo...
March 16, 2024: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38489521/imaging-based-non-invasive-liver-disease-assessment-for-staging-liver-fibrosis-in-chronic-liver-disease-a-systematic-review-supporting-the-aasld-practice-guideline
#14
JOURNAL ARTICLE
Andres Duarte-Rojo, Bachir Taouli, Daniel H Leung, Deborah Levine, Tarek Nayfeh, Bashar Hasan, Yahya Alsawaf, Samer Saadi, Abdul Mounaem Majzoub, Apostolos Manolopoulos, Samir Hafar, Ayca Dundar, M Hassan Murad, Don C Rockey, Mouaz Alsawas, Richard K Sterling
BACKGROUND AND AIMS: Transient elastography (TE), shear-wave elastography (SWE), and/or magnetic resonance elastography (MRE), each providing liver stiffness measurement (LSM), are the most studied imaging-based noninvasive liver disease assessment (NILDA) techniques. To support the American Association for the Study of Liver Diseases guidelines on NILDA, we summarized the evidence on the accuracy of these LSM methods to stage liver fibrosis (F). APPROACH AND RESULTS: A comprehensive search for studies assessing LSM by TE, SWE, or MRE for the identification of significant fibrosis (F2-4), advanced fibrosis (F3-4), or cirrhosis (F4), utilizing histopathology as standard of reference by liver disease etiology in adults or children from inception to April 2022 was performed...
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38486824/static-magnetic-fields-in-regenerative-medicine
#15
REVIEW
Wenjing Xie, Chao Song, Ruowen Guo, Xin Zhang
All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine...
March 2024: APL Bioengineering
https://read.qxmd.com/read/38484441/signal-intensity-of-repaired-posterior-roots-after-transtibial-pullout-repair-for-medial-meniscus-posterior-root-tears-in-stable-knees-magnetic-resonance-imaging-evaluations-at-3-years-postoperatively
#16
JOURNAL ARTICLE
Koki Kawada, Takayuki Furumatsu, Yusuke Yokoyama, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki
BACKGROUND: Only a few studies have assessed signal intensity after pullout repair for medial meniscus posterior root (MMPR) tears (MMPRTs) based on mid-term magnetic resonance imaging (MRI) evaluations. Therefore, this study aimed to assess the quantitative signal intensity of repaired posterior roots over time, up to 3 years postoperatively, and the related factors. METHODS: This study included 36 patients who underwent pullout repair for MMPRTs and MRI examinations using the same MRI system...
March 13, 2024: Knee
https://read.qxmd.com/read/38475669/the-canal-bone-ratio-a-novel-indicator-for-opportunistic-osteoporosis-screening-in-adult-spinal-deformity-patients-through-radiographs
#17
JOURNAL ARTICLE
Yunsheng Wang, Tong Tong, Jiali Zhang, Dechao Miao, Feng Wang, Linfeng Wang
STUDY DESIGN: Retrospective diagnostic study. OBJECTIVES: To evaluate the utility of quantitative assessment of bone density using proximal femoral morphological parameters based on full-spine X-rays. SUMMARY OF BACKGROUND DATA: CT and MRI are commonly utilized methods for opportunistic assessment of bone density. However, there is currently a lack of means to quantitatively assess bone density in adult spinal deformity (ASD) patients through radiographs...
March 13, 2024: Spine
https://read.qxmd.com/read/38473710/use-of-micrornas-as-diagnostic-prognostic-and-therapeutic-tools-for-glioblastoma
#18
REVIEW
David Valle-Garcia, Verónica Pérez de la Cruz, Itamar Flores, Aleli Salazar, Benjamín Pineda, Karla F Meza-Sosa
Glioblastoma (GB) is the most aggressive and common type of cancer within the central nervous system (CNS). Despite the vast knowledge of its physiopathology and histology, its etiology at the molecular level has not been completely understood. Thus, attaining a cure has not been possible yet and it remains one of the deadliest types of cancer. Usually, GB is diagnosed when some symptoms have already been presented by the patient. This diagnosis is commonly based on a physical exam and imaging studies, such as computed tomography (CT) and magnetic resonance imaging (MRI), together with or followed by a surgical biopsy...
February 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472429/deep-learning-reconstructed-lumbar-spine-3d-mri-for-surgical-planning-pedicle-screw-placement-and-geometric-measurements-compared-to-ct
#19
JOURNAL ARTICLE
Frederik Abel, Darren R Lebl, George Gorgy, David Dalton, J Levi Chazen, Elisha Lim, Qian Li, Darryl B Sneag, Ek T Tan
PURPOSE: To test equivalency of deep-learning 3D lumbar spine MRI with "CT-like" contrast to CT for virtual pedicle screw planning and geometric measurements in robotic-navigated spinal surgery. METHODS: Between December 2021 and June 2022, 16 patients referred for spinal fusion and decompression surgery with pre-operative CT and 3D MRI were retrospectively assessed. Pedicle screws were virtually placed on lumbar (L1-L5) and sacral (S1) vertebrae by three spine surgeons, and metrics (lateral deviation, axial/sagittal angles) were collected...
March 12, 2024: European Spine Journal
https://read.qxmd.com/read/38471681/update-trial-investigating-the-effects-of-ultra-processed-versus-minimally-processed-diets-following-uk-dietary-guidance-on-health-outcomes-a-protocol-for-an-8-week-community-based-cross-over-randomised-controlled-trial-in-people-with-overweight-or-obesity
#20
JOURNAL ARTICLE
Samuel Dicken, Janine Makaronidis, Chris van Tulleken, Friedrich C Jassil, Kevin Hall, Adrian Carl Brown, Claudia A M Gandini Wheeler-Kingshott, Abigail Fisher, Rachel Batterham
INTRODUCTION: Obesity increases the risk of morbidity and mortality. A major driver has been the increased availability of ultra-processed food (UPF), now the main UK dietary energy source. The UK Eatwell Guide (EWG) provides public guidance for a healthy balanced diet but offers no UPF guidance. Whether a healthy diet can largely consist of UPFs is unclear. No study has assessed whether the health impact of adhering to dietary guidelines depends on food processing. Furthermore, our study will assess the impact of a 6-month behavioural support programme aimed at reducing UPF intake in people with overweight/obesity and high UPF intakes...
March 11, 2024: BMJ Open
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