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All body MRI

Floriane Rudwill, Donal O'Gorman, Etienne Lefai, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, Allan F Pagano, Angèle Chopard, Anthony Damiot, Claire Laurens, Leanne Hodson, Emmanuelle Canet-Soulas, Martina Heer, Petra Frings Meuthen, Judith Buehlmeier, Natalie Baecker, Laure Meiller, Guillemette Gauquelin-Koch, Stéphane Blanc, Chantal Simon, Audrey Bergouignan
Context: The effects of energy balanced bed-rest on metabolic flexibility has not been thoroughly examined. Objective: We investigated the effects of 21-days bed-rest, with and without whey protein supplementation, on metabolic flexibility while maintaining energy balance. We further hypothesized protein supplementation mitigates metabolic inflexibility by preventing muscle atrophy. Design & Setting: Randomized cross-over longitudinal study conducted at the German Aerospace Center, Cologne, Germany...
March 12, 2018: Journal of Clinical Endocrinology and Metabolism
Xiaoming Liu, Fumin Pan, Zhaoyu Ba, Shanjin Wang, Desheng Wu
BACKGROUND: Diabetes mellitus (DM) and low back pain which is mainly caused by degeneration of the intervertebral discs (IVDs) both are major public health problem worldwide. The present study was designed to investigate the association between type 2 diabetes mellitus (T2D) and severity of lumbar disc degeneration (LDD). METHODS: We retrospectively reviewed patients with low back pain visiting our spine clinic in 2014. Low back pain patients all have the lumbar MRI imaging and no previous treatment...
March 14, 2018: Journal of Orthopaedic Surgery and Research
Robin De Roover, Wouter Crijns, Kenneth Poels, Ronald Peeters, Cédric Draulans, Karin Haustermans, Tom Depuydt
PURPOSE: Liquid fiducial markers have shown to be a promising alternative to solid gold markers in terms of imaging artifact reduction, patient comfort and compatibility with different imaging modalities. This study aims to investigate the performance of the novel BioXmark® liquid marker for state-of-the-art multi-modal imaging used in prostate cancer (PCa) radiotherapy, encompassing kV CT/CBCT, multi-parametric MRI and kV X-ray imaging. In addition, automatic detection of the liquid markers in X-ray imaging for prostate motion monitoring during treatment was investigated...
March 14, 2018: Medical Physics
Julian M M Rogasch, Holger Amthauer, Christian Furth, Patrick Hundsdoerfer, Florian Wedel, Imke Schatka
AIM: According to German guidelines, I-123-MIBG scintigraphy in neuroblastoma (NB) is preferably performed as early (about 4 h p.i.) and late (24 h p.i.) planar imaging and single- photon emission computed tomography (SPECT) or SPECT/CT 24 h p.i. This study evaluated if the work-up could be reduced to a single timepoint. METHODS: Retrospective analysis of 37 examinations in 26 patients (f:8; m:18; age, 0.5-23.5a) with NB (initial, 15; restaging, 22). All 74 (early + late) pairs of ventral/dorsal planar whole-body images were reviewed by 3 independent readers in random order blinded to clinical data (1, certainly physiological; 2, likely physiological; 3, likely malignant; 4, certainly malignant)...
February 2018: Nuklearmedizin. Nuclear Medicine
Liam Bagley, Nasser Al-Shanti, Steven Bradburn, Osamah Baig, Mark Slevin, Jamie S McPhee
BACKGROUND: Regular sprint interval training (SIT) improves whole-body aerobic capacity and muscle oxidative potential, but very little is known about knee extensor anabolic or fatigue resistance adaptations, or whether effects are similar for males and females. The purpose of this study was to compare sex-related differences in knee extensor size, torque-velocity relationship and fatigability adaptations to 12 weeks SIT. METHODS: Sixteen males and fifteen females (mean (SEM) age: 41 (±2...
March 12, 2018: Journal of Strength and Conditioning Research
Matthew T Houdek, Cody C Wyles, Mark S Collins, Benjamin M Howe, Andre Terzic, Atta Behfar, Rafael J Sierra
BACKGROUND: Randomized trials have shown the benefits of injecting bone marrow-derived mesenchymal stem cells (BmMSCs) after standard hip decompression in patients with osteonecrosis of the femoral head. However, the combination of BmMSCs and platelet-rich plasma (PRP) injected into the femoral head after decompression has not been reported previously. This study reports the results in a preliminary series of patients with osteonecrosis of the femoral head treated with BmMSCs plus PRP...
February 2018: Clinical Orthopaedics and related Research
Patrick W Eiken, Thomas D Atwell, A Nicholas Kurup, Stephen A Boorjian, R Houston Thompson, Grant D Schmit
PURPOSE: The purpose of the study was to evaluate the post-contrast appearance of local tumor progression (LTP) following renal ablation to better understand patterns of tumor recurrence and to optimize follow-up imaging protocols. METHODS: From 2002 to 2015, 913 patients underwent 988 renal ablation procedures for treatment of 1064 tumors. LTP was identified in 24 (2.6%) patients during median imaging follow-up of 30 months (range 0-139). One patient with LTP was followed with non-contrast MRI only and was excluded from evaluation...
March 10, 2018: Abdominal Radiology
K-D Sievert, D-L Dräger, F-M Köhn, S Milerski, C Protzel, O W Hakenberg
Penile cancer is often an obvious visual diagnosis but histologic verification should be obtained prior to treatment. The clinical examination should determine the tumor stage and whether it has infiltrated the cavernous bodies and/or the urethra and it should adequately assess the inguinal lymph nodes. Preoperative imaging of the lesion is only indicated in equivocal cases. Curative treatment requires the complete removal of the primary tumor and all metastatic lymph nodes. Lymph node management is the key prognostic factor in the treatment of penile cancer...
March 9, 2018: Der Urologe. Ausg. A
U Plöckinger, V Prasad, A Ziagaki, N Tiling, A Poellinger
BACKGROUND: Pompe disease (PD) is an autosomal recessive, lysosomal storage disease due to a mutation of the acid α-glucosidase (GAA) gene. In adult patients, PD is characterized by slowly progressive limb-girdle and trunk myopathy and restrictive respiratory insufficiency. Enzyme replacement therapy (ERT) is available, improving or stabilizing muscle-function in some and slowing deterioration in other patients. Unfortunately, there is no biomarker available to indicate therapeutic efficacy and/or disease activity...
March 9, 2018: Human Genomics
Lobna Ouldamer, Marie Cayrol, Mathilde Vital, Claire Fièvre, Marion Druelles, Flavie Arbion, Gilles Body, Jean Lévêque, Xavier Fritel
PURPOSE: The aim of the study was to investigate the management and prognosis of axillary cancers from unknown primaries (CUPax). METHODS: We included all patients with lesions described as axillary nodal metastases from an unknown primary referred to four French tertiary breast cancer centres between January 1988 and December 2012. The inclusion criteria comprised: no sign of primary breast cancer on clinical examination nor on imaging (mammography, ultrasonography and breast MRI) and no primary tumour identified elsewhere...
February 23, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Na Yin, Liang Hu, Zhi-Bo Xiao, Chang Liu, Wen-Zhi Chen, Neil Roberts, Jin-Yun Chen, Zhi-Biao Wang
OBJECTIVE: To investigate the factors which may cause thermal injury of abdominal wall structures in ultrasound-guided high-intensity focussed ultrasound (USgHIFU) ablation of uterine fibroids. METHOD: A total of 892 patients with uterine fibroids diagnosed on contrast-enhanced magnetic resonance imaging (MRI) scans received HIFU ablation and follow-up MRI scanning. After therapy, thermal injury to the skin was assessed via measurement of skin redness, blisters, subcutaneous nodules and to the abdominal wall structures via measurement of signal intensity on T2-weighted MRI images...
March 5, 2018: International Journal of Hyperthermia
Xian Hua Gao, Hanumant Chouhan, Gang Lei Liu, Nan Lan, Erick Remer, Luca Stocchi, Jean Ashburn, Tracy L Hull, Bo Shen
Background: There are no published studies on the impact of peripouch fat on pouch outcomes in inflammatory bowel disease (IBD) patients. Methods: Patients with pelvic MRI-DIXON scans from our prospectively maintained Pouch Database between 2002 and 2016 were evaluated. Peripouch fat area was measured on MRI-DIXON-F images at the middle height level of the pouch (area M) and the highest level of the pouch (area H). Results: Of all 1863 patients in the database, 197 eligible patients were included in this study...
March 1, 2018: Inflammatory Bowel Diseases
Matthew J Kraeutler, Eric C McCarty, John W Belk, Brian R Wolf, Carolyn M Hettrich, Shannon F Ortiz, Jonathan T Bravman, Keith M Baumgarten, Julie Y Bishop, Matthew J Bollier, Robert H Brophy, James L Carey, James E Carpenter, Charlie L Cox, Brian T Feeley, John A Grant, Grant L Jones, John E Kuhn, John D Kelly, C Benjamin Ma, Robert G Marx, Bruce S Miller, Brian J Sennett, Matthew V Smith, Rick W Wright, Alan L Zhang
BACKGROUND: Shoulder instability is a common diagnosis among patients undergoing shoulder surgery. PURPOSE: To perform a descriptive analysis of patients undergoing surgery for shoulder instability through a large multicenter consortium. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: All patients undergoing surgery for shoulder instability who were enrolled in the MOON Shoulder Instability Study were included...
March 1, 2018: American Journal of Sports Medicine
Renato S Procianoy, Andrea Lucia A Corso, Maria Gabriela Longo, Leonardo Vedolin, Rita C Silveira
OBJECTIVE: To determine the neurodevelopment outcomes after Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy (HIE) and identify the neonatal Magnetic Resonance Imaging (MRI) findings associated with neurological outcome in a middle-income country. STUDY DESIGN: All infants born after 35 completed weeks' gestation with signs of moderate to severe encephalopathy and evidence of perinatal asphyxia before 6 hours of life were submitted to whole-body hypothermia and were imaged at 18 ± 8...
March 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
Lucas Goense, Alicia S Borggreve, Sophie E Heethuis, Astrid Lhmw van Lier, Richard van Hillegersberg, Stella Mook, Gert J Meijer, Peter Sn van Rossum, Jelle P Ruurda
OBJECTIVE: The perceived burden of diagnostic tests by patients during the assessment of oesophageal cancer warrants attention with the current increase in repeated imaging for purposes of disease monitoring during and after treatment. The purpose of this prospective study was to evaluate the experienced burden associated with repeated MRI and PET/CT examinations during neoadjuvant treatment for oesophageal cancer from the perspective of the patient. METHODS: In 27 patients receiving neoadjuvant chemoradiotherapy (nCRT) for oesophageal cancer MRI and PET/CT examinations were performed before nCRT, during nCRT and before surgery...
March 2, 2018: British Journal of Radiology
Jiangbo Bai, Kunlun Yu, Yaning Sun, Lingde Kong, Yong Shen
Background: The aim of this study was to assess the prevalence of cervical Modic change (MC) in patients with cervical spondylosis and to develop a better understanding of the possible risk factors for the prevalence of MC. Methods: Between January 2014 and April 2017, patients with cervical spondylosis were included in our study. All patients underwent magnetic resonance imaging (MRI) to evaluate the presence of MC. The MC was classified into three types according to the Modic classification...
2018: Journal of Pain Research
Vahudin Zugor, Melanie VON Brandenstein, Ilgar Akbarov, Daniel Porres, Reinhard Kühn, Apostolos P Labanaris
BACKGROUND/AIM: The aim of this study was to evaluate the diagnostic sensitivity, specificity and accuracy of endorectal magnetic resonance imaging (e-MRI), as a preoperative staging modality in the diagnosis of lymph node metastasis (LNM) in patients with prostate cancer (PCa). PATIENTS AND METHODS: Retrospectively, we analyzed data from N=168 patients who underwent radical prostatectomy (RP) between 2004 and 2013 at two tertiary medical centres. Prior to RP all patients underwent an e-MRI...
March 2018: Anticancer Research
Alexander Hoorntje, Suzanne Witjes, Koen L M Koenraadt, Ruud Aarts, Thomas de Weert, Rutger C I van Geenen
Total knee arthroplasty (TKA) is a successful procedure, although up to 20% of patients remain dissatisfied. Preoperative identification of appropriate TKA candidates is essential for improving satisfaction. This study investigated if preoperative radiographic severity was associated with postoperative pain, function, and quality of life after TKA. We performed a cross-sectional cohort study including 327 TKA patients. Radiographic severity was determined by two independent radiologists using the Kellgren and Lawrence (KL) score...
February 28, 2018: Journal of Knee Surgery
Jens M Hohlfeld, Jens Vogel-Claussen, Heike Biller, Dominik Berliner, Korbinian Berschneider, Hanns-Christian Tillmann, Simone Hiltl, Johann Bauersachs, Tobias Welte
BACKGROUND: Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) is associated with reduced biventricular end-diastolic volumes and increased morbidity and mortality. The combination of a long-acting β agonist (LABA) and a muscarinic antagonist (LAMA) is more effective in reducing hyperinflation than LABA-inhaled corticosteroid combination therapy but whether dual bronchodilation improves cardiac function is unknown. METHODS: We did a double-blind, randomised, two-period crossover, placebo-controlled, single-centre study (CLAIM) at the Fraunhofer Institute of Toxicology and Experimental Medicine (Hannover, Germany), a specialty clinic...
February 21, 2018: Lancet Respiratory Medicine
Dale W Litzenberg, Daniel G Muenz, Paul G Archer, William C Jackson, Daniel A Hamstra, Jason W Hearn, Matthew J Schipper, Daniel E Spratt
PURPOSE: Investigate the impact on prostate orientation caused by use and removal of a Foley catheter, and the dosimetric impact on men prospectively treated with prostate stereotactic body radiotherapy (SBRT). METHODS: Twenty-two men underwent a CT simulation with a Foley in place (FCT), followed immediately by a second treatment planning simulation without the Foley (TPCT). The change in prostate orientation was determined by rigid registration of three implanted transponders between FCT and TPCT and compared to measured orientation changes during treatment...
February 23, 2018: Medical Physics
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