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https://www.readbyqxmd.com/read/29350186/mri-tracing-non-invasive-tio2-based-nanoparticles-motivated-by-ultrasound-for-multi-mechanism-therapy-of-prostatic-cancer
#1
Pu Yuan, Dongkui Song
To reduce the side effects of chemotherapy and reach effective and safe therapy of prostate cancer, herein, a simple but multifunctional system TiO2:Gd@DOX/FA motivated by ultrasound was developed for MRI guided multi-mechanism therapy of prostate cancer. TiO2 nanoparticles served as a sonosensitizer as well as a nanocarrier with pH-responsive release of DOX. Doping of Gd could not only endow TiO2 the ability of magnetic resonance imaging (MRI), but also further improve sonodynamic ability of TiO2. The characterization revealed the as-prepared TiO2:Gd@DOX/FA showed sensitive pH-responsive drug release, high ROS production, T1-MRI contrast performance and excellent biocompatibility...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29342038/utility-of-noncontrast-magnetic-resonance-imaging-for-detection-of-recurrent-vestibular-schwannoma
#2
Jamie C Williams, Carrie M Carr, Laurence J Eckel, Amy L Kotsenas, Christopher H Hunt, Matthew L Carlson, John I Lane
BACKGROUND: Gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI) (T1WI) is the conventional imaging technique of choice to detect vestibular schwannoma (VS) recurrence or regrowth, despite suboptimal specificity secondary to enhancing postoperative changes. Furthermore, recent concerns regarding the accumulation of gadolinium in body tissues have led for a call to reduce the number of contrast-enhanced examinations. The objective of the current study is to evaluate the diagnostic accuracy of high-resolution noncontrast (three-dimensional [3D] T2) MRI relative to gadolinium-enhanced T1WI in the detection of VS recurrence after resection...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29339139/improved-coronary-magnetic-resonance-angiography-using-gadobenate-dimeglumine-in-pediatric-congenital-heart-disease
#3
Miguel Silva Vieira, Markus Henningsson, Nathalie Dedieu, Vassilios S Vassiliou, Aaron Bell, Sujeev Mathur, Kuberan Pushparajah, Carlos Alberto Figueroa, Tarique Hussain, René Botnar, Gerald F Greil
BACKGROUND: CMRA in pediatrics remains challenging due to the smaller vessel size, high heart rates (HR), potential image degradation caused by limited patient cooperation and long acquisition times. High-relaxivity contrast agents have been shown to improve coronary imaging in adults, but limited data is available in children. We sought to investigate whether gadobenate dimeglumine (Gd-BOPTA) together with self-navigated inversion-prepared coronary magnetic resonance angiography (CMRA) sequence design improves coronary image quality in pediatric patients...
January 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29336979/prostate-magnetic-resonance-imaging-the-truth-lies-in-the-eye-of-the-beholder
#4
Joseph C Riney, Nabeel E Sarwani, Shehzad Siddique, Jay D Raman
PURPOSE: To determine the diagnostic accuracy and interobserver variability of radiologic interpretation of magnetic resonance imaging (MRI) performed for surgical planning before prostatectomy. PATIENTS AND METHODS: The records of 233 men undergoing prostatectomy with presurgical multiparametric 3T surface body coil MRI were reviewed. All initial films were read by a fellowship-trained body radiologist provided with relevant clinical information. A senior radiologist then reread all pelvic MRIs blinded to the initial interpretation with findings from both readings compared to final pathology...
January 11, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#5
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29325432/risk-factors-for-primary-failure-of-metallic-ureteral-stents-experience-from-a-tertiary-center
#6
Jui-Shan Hsu, Chao-Yuan Huang, Kao-Lang Liu, Po-Ming Chow
INTRODUCTION: We provide primary patency rate of metallic ureteral stents in cancer patients and investigate the factors affecting primary patency. METHODS: All cancer patients who had received metallic stents for malignant ureteral obstruction between July 2009 and November 2012 in our institute were included. No patients were excluded. Patient profiles, imaging studies, and lab data were collected. Patient profiles included age, gender, body height, body weight, body mass index, cancer types, treatment for cancer, response to cancer treatment, methods of stent insertion, and prior ordinary stents...
January 12, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29322834/a-tertiary-centre-experience-of-thoracic-ct-and-cardiac-mri-scanning-in-the-presence-of-a-reveal-linq-insertable-cardiac-monitoring-system-a-case-series-review-of-artefact-patient-safety-and-data-preservation
#7
Benedict M Wiles, Caroline A Illingworth, Michael Lg Couzins, Paul R Roberts, Stephen P Harden
OBJECTIVE: At our tertiary cardiothoracic centre cardiac MRI and thoracic CT scans are performed in patients with implanted LINQ devices. The degree of foreign body artefact associated with the LINQ device, and its clinical importance, has not previously been assessed. A case series review was therefore performed with a simultaneous review of patient safety and data loss events, secondary to the MRI environment. METHODS: A local database search identified LINQ device patients who underwent thoracic CT or cardiac MRI scans between March 2014 and December 2016...
January 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29320532/automatic-outer-and-inner-breast-tissue-segmentation-using-multi-parametric-mri-images-of-breast-tumor-patients
#8
Snekha Thakran, Subhajit Chatterjee, Meenakshi Singhal, Rakesh Kumar Gupta, Anup Singh
The objectives of the study were to develop a framework for automatic outer and inner breast tissue segmentation using multi-parametric MRI images of the breast tumor patients; and to perform breast density and tumor tissue analysis. MRI of the breast was performed on 30 patients at 3T-MRI. T1, T2 and PD-weighted(W) images, with and without fat saturation(WWFS), and dynamic-contrast-enhanced(DCE)-MRI data were acquired. The proposed automatic segmentation approach was performed in two steps. In step-1, outer segmentation of breast tissue from rest of body parts was performed on structural images (T2-W/T1-W/PD-W without fat saturation images) using automatic landmarks detection technique based on operations like profile screening, Otsu thresholding, morphological operations and empirical observation...
2018: PloS One
https://www.readbyqxmd.com/read/29313360/diagnostic-bone-imaging-in-patients-with-prostate-cancer-patient-experience-and-acceptance-of-naf-pet-ct-choline-pet-ct-whole-body-mri-and-bone-spect-ct
#9
Eva Dyrberg, Emil L Larsen, Helle W Hendel, Henrik S Thomsen
Background Patient acceptance is an important factor when implementing imaging methods in clinical practice in line with availability, diagnostic accuracy, and cost-effectiveness. Purpose To investigate patient experience and acceptance regarding18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT), 11 C-choline-PET/CT, whole-body magnetic resonance imaging (WB-MRI), and 99mTc-hydroxymethane diphosphonate (HDP) single photon emission/computed tomography (SPECT/CT). Material and Methods One hundred and forty-nine patients with prostate cancer filled in a questionnaire regarding their experience of the imaging procedures they had been undergoing as part of a diagnostic accuracy study...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29305910/the-development-of-brain-white-matter-microstructure
#10
Catherine Lebel, Sean Deoni
Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes. Processes including myelination and synaptogenesis occur rapidly across the first 2-3 years of life, and ongoing brain remodeling continues into young adulthood. Studies have sought to characterize the patterns of structural brain development, and early studies predominately relied upon gross anatomical measures of brain structure, morphology, and organization. MRI offers the ability to characterize and quantify a range of microstructural aspects of brain tissue that may be more closely related to fundamental neurodevelopmental processes...
January 3, 2018: NeuroImage
https://www.readbyqxmd.com/read/29302738/comparison-between-the-diagnostic-accuracies-of-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-and-conventional-imaging-in-recurrent-urothelial-carcinomas-a-retrospective-multicenter-study
#11
Fabio Zattoni, Elena Incerti, Michele Colicchia, Paolo Castellucci, Stefano Panareo, Maria Picchio, Federico Fallanca, Alberto Briganti, Marco Moschini, Andrea Gallina, Jeffrey R Karnes, Val Lowe, Stefano Fanti, Riccardo Schiavina, Ilaria Rambaldi, Vincenzo Ficarra, Laura Evangelista
PURPOSE: To determine the performance accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) after primary tumor treatment for both bladder cancer (BC) and upper tract urothelial cancer (UTUC). To compare the accuracy of FDG PET/CT with that of contrast-enhanced-ceCT and magnetic resonance imaging (MRI). METHODS: Data of patients with recurrent urothelial carcinomas (UC) after primary treatment were collected in a retrospective, international multicenter study...
January 4, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29302065/adulthood-leukodystrophies
#12
REVIEW
Wolfgang Köhler, Julian Curiel, Adeline Vanderver
The leukodystrophies are a group of inherited white matter disorders with a heterogeneous genetic background, considerable phenotypic variability and disease onset at all ages. This Review focuses on leukodystrophies with major prevalence or primary onset in adulthood. We summarize 20 leukodystrophies with adult presentations, providing information on the underlying genetic mutations and on biochemical assays that aid diagnosis, where available. Definitions, clinical characteristics, age of onset, MRI findings and treatment options are all described, providing a comprehensive overview of the current knowledge of the various adulthood leukodystrophies...
January 5, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29295870/effect-of-liraglutide-on-atrial-natriuretic-peptide-adrenomedullin-and-copeptin-in-pcos
#13
Signe Frøssing, Malin Nylander, Caroline Kistorp, Sven O Skouby, Jens Faber
CONTEXT: Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of the delicate system controlling fluid and hemodynamic homeostasis through vascular tonus and diuresis. The GLP-1 receptor agonist liraglutide, developed for treatment of type 2 diabetes (T2D), improves cardiovascular outcomes in patients with T2D including a decrease in particular MR-proANP...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29290197/primary-cns-lymphoma-vs-tumefactive-multiple-sclerosis-a-diagnostic-challenge
#14
Sameen Bin Naeem, Farheen Niazi, Atif Baig, Hina Sadiq, Mubbasher Sattar
Primary CNS (central nervous system) lymphoma is a rare condition with the incidence of less than 1% of all non-Hodgkin lymphomas (NHLs) and approximately 2% of all primary brain tumours. Diagnosis can be challenging and necessitates brain biopsy for definitive diagnosis. A 41-year male presented with history of impaired cognition, facial asymmetry, visual impairment and left sided body weakness. MRI brain demonstrated multiple enhancing lesions with one larger lesion in right basal ganglia with surrounding oedema and mass effect...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29288410/central-nervous-system-involvement-in-rheumatoid-arthritis-possible-role-of-chronic-inflammation-and-tnf-blocker-therapy
#15
Sinem Sağ, Mustafa Serdar Sağ, Ibrahim Tekeoğlu, Ayhan Kamanlı, Kemal Nas, Bilgehan Atilgan Acar
Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. Although peripheral nervous system anomalies are observed widely in RA, very few case reports on changes in the central nervous system (CNS) have been published. In recent years, the pathophysiology of CNS involvement that can occur in RA has attracted a great deal of attention. Emphasis has focused on the possibility that CNS involvement occurs due to blood-brain barrier (BBB) damage associated with chronic inflammation...
December 29, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29281244/high-density-lipoprotein-nanobiologics-for-precision-medicine
#16
Willem J M Mulder, Mandy M T van Leent, Marnix Lameijer, Edward A Fisher, Zahi A Fayad, Carlos Pérez-Medina
Nature is an inspirational source for biomedical engineering developments. Particularly, numerous nanotechnological approaches have been derived from biological concepts. For example, among many different biological nanosized materials, viruses have been extensively studied and utilized, while exosome research has gained much traction in the 21st century. In our body, fat is transported by lipoproteins, intriguing supramolecular nanostructures that have important roles in cell function, lipid metabolism, and disease...
December 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29280504/cartilage-quantitative-t2-relaxation-time-2-to-4-years-following-isolated-anterior-cruciate-ligament-reconstruction
#17
Xinyang Wang, Tim V Wrigley, Kim L Bennell, Yuanyuan Wang, Karine Fortin, Flavia M Cicuttini, David G Lloyd, Adam L Bryant
Cartilage T2 relaxation time in isolated anterior cruciate ligament reconstruction (ACLR) without concomitant meniscal pathology and their changes over time remain unclear. The purpose of this exploratory study was to: 1) compare cartilage T2 relaxation time (T2 values) in people with isolated ACLR at 2-3 years post-surgery (baseline) and matched healthy controls and; 2) evaluate the subsequent 2-year change in T2 values in people with ACLR. Twenty-eight participants with isolated ACLR and 9 healthy volunteers underwent knee magnetic resonance imaging (MRI) at baseline; 16 ACLR participants were re-imaged 2 years later...
December 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29279689/a-solitary-intestinal-myofibroma-a-rare-cause-of-neonatal-anemia
#18
Janna S E Ottenhoff, Peter G J Nikkels, C E J Terwisscha van Scheltinga, L Naeije
Solitary infantile myofibroma with visceral involvement is very rare. We present an unusual case of a solitary myofibroma with abdominal localization in a 1-day-old female neonate who presented with severe anemia and rectal bleeding. A bleeding myofibroma was found, located in the wall of the jejunum, and totally resected. In case of a solitary lesion, treatment is relatively easy and effective, with excellent prognosis after total resection. The multiple form (myofibromatosis) has a poor prognosis with low survival rates...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29275455/early-detection-of-metastases-using-whole-body-mri-for-initial-staging-and-routine-follow-up-of-myxoid-liposarcoma
#19
Natalia Gorelik, Santhosh Mauvva Venkatesh Reddy, Robert E Turcotte, Krista Goulding, Sungmi Jung, Thierry Alcindor, Thomas I Powell
OBJECTIVE: To define the role of whole-body MRI (WBMRI) for initial staging and routine follow-up of myxoid liposarcoma (MLS). MATERIALS AND METHODS: A retrospective review of all the patients with MLS who underwent WBMRI for initial staging and routine follow-up at our institution between October 1, 2006, and September 30, 2016 was performed. Patient demographics, clinical presentation, imaging findings, tumor histology, and occurrence and location of metastatic disease were recorded...
December 23, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29273015/diagnostic-accuracy-of-18f-fdg-pet-ct-and-mr-imaging-in-patients-with-adenoid-cystic-carcinoma
#20
Verena Ruhlmann, Thorsten D Poeppel, Johannes Veit, James Nagarajah, Lale Umutlu, Thomas K Hoffmann, Andreas Bockisch, Ken Herrmann, Wolfgang Sauerwein
BACKGROUND: The aim of this study was to evaluate the value of 18F-FDG PET/CT (PET/CT) and MRI for local and/or whole-body restaging of adenoid cystic carcinoma of the head and neck (ACC). METHODS: Thirty-six patients with ACC underwent conventional MRI of the head and neck and a whole-body PET/CT and were analysed with regards to detection of a local tumor recurrence, lymph node or distant metastases. A consensus interpretation of all available imaging data was used as reference standard...
December 22, 2017: BMC Cancer
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