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https://www.readbyqxmd.com/read/29290585/a-human-ips-model-implicates-embryonic-b-myeloid-fate-restriction-as-developmental-susceptibility-to-b%C3%A2-acute-lymphoblastic-leukemia-associated-etv6-runx1
#1
Charlotta Böiers, Simon E Richardson, Emma Laycock, Alya Zriwil, Virginia A Turati, John Brown, Jason P Wray, Dapeng Wang, Chela James, Javier Herrero, Ewa Sitnicka, Stefan Karlsson, Andrew J H Smith, Sten Erik W Jacobsen, Tariq Enver
ETV6-RUNX1 is associated with childhood acute B-lymphoblastic leukemia (cALL) functioning as a first-hit mutation that initiates a clinically silent pre-leukemia in utero. Because lineage commitment hierarchies differ between embryo and adult, and the impact of oncogenes is cell-context dependent, we hypothesized that the childhood affiliation of ETV6-RUNX1 cALL reflects its origins in a progenitor unique to embryonic life. We characterize the first emerging B cells in first-trimester human embryos, identifying a developmentally restricted CD19-IL-7R+ progenitor compartment, which transitions from a myeloid to lymphoid program during ontogeny...
December 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29286888/a-study-of-sexual-relationship-power-among-young-women-who-inject-drugs-and-their-sexual-partners
#2
Meghan D Morris, Martha E Montgomery, Alya Briceno, Jennifer L Evans, Erin V W Andrew, Kimberly Page, Judith A Hahn
BACKGROUND: To date, research applying the Sexual Relationship Power Scale (SRPS) has been limited to sexual risk behaviors. OBJECTIVE: We measured levels of sexual relationship power and examined associations between sexual relationship power and injecting and sexual behaviors that place women at increased risk for blood borne infections. METHODS: Using data from a cross-sectional study of young women who inject drugs (WWID) in San Francisco, USA, logistic regression analysis identified independent associations between SRPS and subscale scores (relationship control [RC] and decision making dominance [DMD]) and injecting and sexual behaviors...
December 29, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29189976/validation-of-knowledge-and-adherence-assessment-tools-among-patients-on-warfarin-therapy-in-a-saudi-hospital-anticoagulant-clinic
#3
Sireen Abdul Rahim Shilbayeh, Wejdan Ali Almutairi, Sarah Ahmed Alyahya, Nouf Hayef Alshammari, Eiad Shaheen, Alya Adam
Background Although it can result in serious complications due to its narrow therapeutic index, warfarin is widely used in the treatment and prevention of thromboembolic disorders. However, patients' adherence and knowledge are determinants of therapeutic success. Objective We sought to validate instruments to provide a reliable means of identifying gaps in patient understanding and nonadherence to inform targeted pharmacists' interventions to improve these measures. Methods A cross-sectional survey was conducted...
November 30, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29189716/recent-advances-in-nucleic-acid-targeting-probes-and-supramolecular-constructs-based-on-pyrene-modified-oligonucleotides
#4
REVIEW
Olga A Krasheninina, Darya S Novopashina, Evgeny K Apartsin, Alya G Venyaminova
In this review, we summarize the recent advances in the use of pyrene-modified oligonucleotides as a platform for functional nucleic acid-based constructs. Pyrene is of special interest for the development of nucleic acid-based tools due to its unique fluorescent properties (sensitivity of fluorescence to the microenvironment, ability to form excimers and exciplexes, long fluorescence lifetime, high quantum yield), ability to intercalate into the nucleic acid duplex, to act as a π-π-stacking (including anchoring) moiety, and others...
November 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29182794/acquired-transverse-stripes-on-the-fingernails-a-quiz
#5
Alya Alkhars, Marion Delaplace, Muriel Ouedraogo, Laurent Machet
No abstract text is available yet for this article.
November 28, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29168067/continued-transmission-of-hiv-among-young-adults-who-inject-drugs-in-san-francisco-still-room-for-improvement
#6
Ali Mirzazadeh, Jennifer L Evans, Judith A Hahn, Jennifer Jain, Alya Briceno, Stephen Shiboski, Paula J Lum, Christopher Bentsen, Geoff Davis, Kathy Shriver, Melanie Dimapasoc, Mars Stone, Michael P Busch, Kimberly Page
We measured HIV incidence rate, trend and risk factors in 564 HIV-negative young people (< 30 years) who inject drugs (PWID) in San Francisco between 2000 and 2014. HIV incidence was 0.93/100 person-years (PY; 95% CI 0.50, 1.73). Incidence varied between 0.62/100 PY in 2000-2002 and 1.06/100 PY in 2012-2014 (P for trend = 1.0). HIV incidence varied significantly (P < 0.01) by race/ethnicity: among Hispanics it was 8.19/100 PY (95% CI 3.41, 19.68), African-Americans 4.59/100 PY (95% CI 1.15, 18.37), and Whites 0...
November 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29156000/structural-rearrangements-in-mrna-upon-its-binding-to-human-80s-ribosomes-revealed-by-epr-spectroscopy
#7
Alexey A Malygin, Dmitri M Graifer, Maria I Meschaninova, Alya G Venyaminova, Ivan O Timofeev, Andrey A Kuzhelev, Olesya A Krumkacheva, Matvey V Fedin, Galina G Karpova, Elena G Bagryanskaya
The model mRNA (MR), 11-mer RNA containing two nitroxide spin labels at the 5'- and 3'-terminal nucleotides and prone to form a stable homodimer (MR)2, was used for Electron Paramagnetic Resonance study of structural rearrangements in mRNA occurring upon its binding to human 80S ribosomes. The formation of two different types of ribosomal complexes with MR was observed. First, there were stable complexes where MR was fixed in the ribosomal mRNA-binding channel by the codon-anticodon interaction(s) with cognate tRNA(s)...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29145358/progress-in-rubella-and-congenital-rubella-syndrome-control-and-elimination-worldwide-2000-2016
#8
Gavin B Grant, Susan E Reef, Minal Patel, Jennifer K Knapp, Alya Dabbagh
Although rubella virus infection usually causes a mild fever and rash illness in children and adults, infection during pregnancy, especially during the first trimester, can result in miscarriage, fetal death, stillbirth, or infants with a constellation of congenital malformations known as congenital rubella syndrome (CRS) (1). Rubella is a leading vaccine-preventable cause of birth defects. Preventing these adverse pregnancy outcomes is the focus of rubella vaccination programs. In 2011, the World Health Organization (WHO) updated guidance on the preferred strategy for introduction of rubella-containing vaccine (RCV) into national immunization schedules and recommended an initial vaccination campaign, usually targeting children aged 9 months-14 years (1)...
November 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29120240/routes-to-drug-design-via-bioisosterism-of-carboxyl-and-sulfonamide-groups
#9
Alya A Arabi
AIM: The similarity in the biological function of the bioisosteric pair, carboxyl and sulfonamide functional groups, is studied using the quantitative tool, average electron density of the bioisosteric moiety in drug molecules and the qualitative tool, electrostatic potential. Results/methodology: Five different capping groups (methyl, phenyl, chlorine, hydrogen and amine) were considered to investigate the effect of the environment on the properties of the bioisosteres. The molecules were considered in their neutral and anionic forms to account for the change in pH depending on the medium of the drug-receptor interactions...
November 9, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29093686/what-s-in-a-typeface-evidence-of-the-existence-of-print-personalities-in-arabic
#10
Timothy R Jordan, Alya S AlShamsi, Hajar A K Yekani, Maryam AlJassmi, Nada Al Dosari, Ehab W Hermena, Mercedes Sheen
Previous research suggests that different typefaces can be perceived as having distinct personality characteristics (such as strength, elegance, friendliness, romance, and humor) and that these "print personalities" elicit information in the reader that is in addition to the meaning conveyed linguistically by words. However, research in this area has previously been conducted using only English stimuli and so it may be that typefaces in English, and other languages using the Latinate alphabet, lend themselves unusually well to eliciting perception of print personalities, and the phenomenon is not a language universal...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29073125/progress-toward-regional-measles-elimination-worldwide-2000-2016
#11
Alya Dabbagh, Minal K Patel, Laure Dumolard, Marta Gacic-Dobo, Mick N Mulders, Jean-Marie Okwo-Bele, Katrina Kretsinger, Mark J Papania, Paul A Rota, James L Goodson
The fourth United Nations Millennium Development Goal, adopted in 2000, set a target to reduce child mortality by two thirds by 2015. One indicator of progress toward this target was measles vaccination coverage (1). In 2010, the World Health Assembly (WHA) set three milestones for measles control by 2015: 1) increase routine coverage with the first dose of a measles-containing vaccine (MCV1) among children aged 1 year to ≥90% at the national level and to ≥80% in every district; 2) reduce global annual measles incidence to <5 cases per million population; and 3) reduce global measles mortality by 95% from the 2000 estimate (2)...
October 27, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29063392/prokaryotic-community-profiling-of-local-algae-wastewaters-using-advanced-16s-rrna-gene-sequencing
#12
Alya Limayem, Andrew Micciche, Bina Nayak, Shyam Mohapatra
Algae biomass-fed wastewaters are a promising source of lipid and bioenergy manufacture, revealing substantial end-product investment returns. However, wastewaters would contain lytic pathogens carrying drug resistance detrimental to algae yield and environmental safety. This study was conducted to simultaneously decipher through high-throughput advanced Illumina 16S ribosomal RNA (rRNA) gene sequencing, the cultivable and uncultivable bacterial community profile found in a single sample that was directly recovered from the local wastewater systems...
October 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29051236/first-complete-genome-sequence-of-methicillin-resistant-staphylococcus-aureus-strain-so-1977-isolated-from-khartoum-sudan
#13
Sofia B Mohamed, Mohamed S Ali, Faisal M Alamir, Tahani B Alyas, Abdallah E Ahmed, Almeen O Seed, Rihab A Omer
Methicillin-resistant Staphylococcus aureus is increasingly becoming resistant to most antibiotics and consequently has become a challenging public health problem in Sudan. The present study documented the first complete genome sequence of strain SO-1977, isolated from a contaminated wound in Sudan.
October 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28980111/neuroprotective-effects-of-curcumin-against-acetamiprid-induced-neurotoxicity-and-oxidative-stress-in-the-developing-male-rat-cerebellum-biochemical-histological-and-behavioral-changes
#14
Ines Bini Dhouib, Alya Annabi, Raoudha Doghri, Ines Rejeb, Yosra Dallagi, Yassin Bdiri, Mohamed Montassar Lasram, Amel Elgaaied, Raja Marrakchi, Saloua Fazaa, Asma Gati
Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. This study aimed to investigate the effect of curcumin on neurobehavioral and neuropathological alterations induced by acetamiprid on male rats. Three groups of ten male Wistar rats each were used for the study: the first was a control group (CTR) that did not consume acetamiprid (ACE); the second was an experimental group (ACE) that consumed 40 mg/kg body weight/day of acetamiprid; and the third group (CUR) received curcumin (100 mg/kg) and acetamiprid (40 mg/kg) in combination...
October 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28933305/epidemiology-of-diabetes-mellitus-in-the-united-arab-emirates
#15
Hira Abdul Razzak, Alya Harbi, Wael Shelpai, Ahmad Qawas
Background/ Objective: Diabetes mellitus is a non-communicable disease which has become a major global public health issue. This systematic review summarized epidemiological studies related to the prevalence, risk factors, complications, incidence, knowledge, attitude and practices of Diabetes Mellitus (DM) among Arab population in the United Arab Emirates (UAE). METHOD: PubMed, Scopus databases, Science direct, Wiley online library, and other local journals were searched to identify relevant literature using appropriate keywords to retrieve studies conducted in the UAE...
September 20, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28923603/unraveling-the-expression-of-genes-involved-in-the-biosynthesis-pathway-of-cardiolipin-and-phosphatidylethanolamine-in-salmonella-hadar-grown-under-static-magnetic-field-200%C3%A2-mt
#16
Ramla Ben Mouhoub, Ahlem Mansouri, Khadidja Aliliche, Hamida Beghalem, Ahmed Landoulsi, Alya El May
We aimed in this work to evaluate the effect of static magnetic field 200 mT (SMF) on the expression of genes involved in the biosynthetic pathway of cardiolipin: g3pd, plsB, cdsA, pgsA, pgpA, cls and phosphatidylethanolamine: pssA and psd in Salmonella enterica subsp enterica serovar Hadar. Bacteria were exposed to a SMF during 3, 6 and 9 h. RNA extraction was followed by Reverse Transcriptase Polymerase Chain Reaction RT-PCR. The relative quantification of mRNA expression levels using 16S rRNA doesn't change during the time exposure...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28829094/amphiphilic-carbosilane-dendrons-as-a-novel-synthetic-platform-toward-micelle-formation
#17
Carlos E Gutierrez-Ulloa, Marina Yu Buyanova, Evgeny K Apartsin, Alya G Venyaminova, F Javier de la Mata, Mercedes Valiente, Rafael Gómez
A novel family of amphiphilic ionic carbosilane dendrons containing fatty acids at the focal point were synthesized and characterized. They spontaneously self-assembled in aqueous solution into micelles both in the absence and presence of salt, as confirmed by surface tension, conductivity, and DLS measurements. Dendron based micelles have spherical shapes and increase in size on decreasing dendron generation. These dendritic micelles have been demonstrated to be able to form complexes with therapeutic macromolecules such as siRNA and show a high loading capacity for drugs such as procaine, suggesting their potential use as nanocarriers for therapeutics...
September 13, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28749478/molecular-autopsy-in-maternal-fetal-medicine
#18
Hanan E Shamseldin, Wesam Kurdi, Fatima Almusafri, Maha Alnemer, Alya Alkaff, Zeneb Babay, Amal Alhashem, Maha Tulbah, Nada Alsahan, Rubina Khan, Bahauddin Sallout, Elham Al Mardawi, Mohamed Zain Seidahmed, Niema Meriki, Yasser Alsaber, Alya Qari, Ola Khalifa, Wafaa Eyaid, Zuhair Rahbeeni, Ahmed Kurdi, Mais Hashem, Tarfa Alshidi, Eman Al-Obeid, Firdous Abdulwahab, Niema Ibrahim, Nour Ewida, Karen El-Akouri, Mariam Al Mulla, Tawfeg Ben-Omran, Matthias Pergande, Sebahattin Cirak, Saeed Al Tala, Ranad Shaheen, Eissa Faqeih, Fowzan S Alkuraya
PurposeThe application of genomic sequencing to investigate unexplained death during early human development, a form of lethality likely enriched for severe Mendelian disorders, has been limited.MethodsIn this study, we employed exome sequencing as a molecular autopsy tool in a cohort of 44 families with at least one death or lethal fetal malformation at any stage of in utero development. Where no DNA was available from the fetus, we performed molecular autopsy by proxy, i.e., through parental testing.ResultsPathogenic or likely pathogenic variants were identified in 22 families (50%), and variants of unknown significance were identified in further 15 families (34%)...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28743110/clinical-endocrine-and-molecular-genetic-analysis-of-a-large-cohort-of-saudi-arabian-patients-with-laron-syndrome
#19
Abdullah A Al-Ashwal, Afaf Al-Sagheir, Khushnooda Ramzan, Mohammed Al-Owain, Rabab Allam, Alya Qari, Nouf S Al-Numair, Faiqa Imtiaz
BACKGROUND/AIMS: Laron syndrome (LS) is an autosomal recessive disease characterized by marked short stature and very low serum IGF-1 and IGFBP-3 levels. This study assessed the clinical and endocrine features alongside determining the growth hormone receptor gene (GHR) mutation in Saudi Arabian patients with LS in order to establish whether or not a genotype/phenotype correlation is evident in this large cohort. SUBJECTS AND METHODS: A total of 40 Saudi Arabian patients with a suspected diagnosis of LS were recruited and subjected to a full clinical and endocrine investigation together with direct sequencing of the coding regions of the GHR gene...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28727678/progress-toward-measles-elimination-bangladesh-2000-2016
#20
Sudhir Khanal, Rajendra Bohara, Stephen Chacko, Mohammad Sharifuzzaman, Mohammad Shamsuzzaman, James L Goodson, Alya Dabbagh, Katrina Kretsinger, Deepak Dhongde, Jayantha Liyanage, Sunil Bahl, Arun Thapa
In 2013, at the 66th session of the Regional Committee of the World Health Organization (WHO) South-East Asia Region (SEAR), a regional goal was established to eliminate measles and control rubella and congenital rubella syndrome* by 2020 (1). WHO-recommended measles elimination strategies in SEAR countries include 1) achieving and maintaining ≥95% coverage with 2 doses of measles-containing vaccine (MCV) in every district, delivered through the routine immunization program or through supplementary immunization activities (SIAs)(†); 2) developing and sustaining a sensitive and timely measles case-based surveillance system that meets targets for recommended performance indicators; and 3) developing and maintaining an accredited measles laboratory network (2)...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
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