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https://www.readbyqxmd.com/read/27898020/multivalent-aptamers-versatile-tools-for-diagnostic-and-therapeutic-applications
#1
REVIEW
Mariya Vorobyeva, Pavel Vorobjev, Alya Venyaminova
Nucleic acid aptamers generated through an in vitro selection are currently extensively applied as very valuable biomolecular tools thanks to their prominent advantages. Diversity of spatial structures, ease of production through chemical synthesis and a large variety of chemical modifications make aptamers convenient building blocks for the generation of multifunctional constructs. An opportunity to combine different aptamer functionalities with other molecules of interest such as reporter groups, nanoparticles, chemotherapeutic agents, siRNA or antisense oligonucleotides provides a widest range of applications of multivalent aptamers...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27884956/regional-effects-of-streptozotocin-induced-diabetes-on-shortening-and-calcium-transport-in-epicardial-and-endocardial-myocytes-from-rat-left-ventricle
#2
Manal M A Smail, Muhammad A Qureshi, Anatoliy Shmygol, Murat Oz, Jaipaul Singh, Vadym Sydorenko, Alya Arabi, Frank C Howarth, Lina Al Kury
In the heart, the left ventricle pumps blood at higher pressure than the right ventricle. Within the left ventricle, the electromechanical properties of ventricular cardiac myocytes vary transmurally and this may be related to the gradients of stress and strain experienced in vivo across the ventricular wall. Diabetes is also associated with alterations in hemodynamic function. The aim of this study was to investigate shortening and Ca(2+) transport in epicardial (EPI) and endocardial (ENDO) left ventricular myocytes in the streptozotocin (STZ)-induced diabetic rat...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27855655/two-hits-in-one-whole-genome-sequencing-unveils-lig4-syndrome-and-urofacial-syndrome-in-a-case-report-of-a-child-with-complex-phenotype
#3
Abeer Fadda, Fiza Butt, Sara Tomei, Sara Deola, Bernice Lo, Amal Robay, Alya Al-Shakaki, Noor Al-Hajri, Ronald Crystal, Marios Kambouris, Ena Wang, Francesco M Marincola, Khalid A Fakhro, Chiara Cugno
BACKGROUND: Ligase IV syndrome, a hereditary disease associated with compromised DNA damage response mechanisms, and Urofacial syndrome, caused by an impairment of neural cell signaling, are both rare genetic disorders, whose reports in literature are limited. We describe the first case combining both disorders in a specific phenotype. CASE PRESENTATION: We report a case of a 7-year old girl presenting with a complex phenotype characterized by multiple congenital abnormalities and dysmorphic features, microcephaly, short stature, combined immunodeficiency and severe vesicoureteral reflux...
November 17, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27832050/progress-toward-regional-measles-elimination-worldwide-2000-2015
#4
Minal K Patel, Marta Gacic-Dobo, Peter M Strebel, Alya Dabbagh, Mick N Mulders, Jean-Marie Okwo-Bele, Laure Dumolard, Paul A Rota, Katrina Kretsinger, James L Goodson
Adopted in 2000, United Nations Millennium Development Goal 4 set a target to reduce child mortality by two thirds by 2015, with measles vaccination coverage as one of the progress indicators. In 2010, the World Health Assembly (WHA) set three milestones for measles control by 2015: 1) increase routine coverage with the first dose of measles-containing vaccine (MCV1) for children aged 1 year to ≥90% nationally and ≥80% in every district; 2) reduce global annual measles incidence to <5 cases per 1 million population; and 3) reduce global measles mortality by 95% from the 2000 estimate (1,2)...
November 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27815994/traumatic-jejunal-hematoma-in-childhood-a-case-report-and-review-of-literature
#5
Noura Al-Zarouni, Labib Al-Ozaibi, Ali Khammas, Nusaiba Al-Suwaidi, Alya Al-Mazroui, Faisal Al-Badri
INTRODUCTION: Intramural jejunal hematoma is a very rare condition with only few cases reported in the literature. It rarely occurs spontaneously, and is mostly seen in hemophiliac patients and is also associated with abdominal trauma. It occurs more commonly in children than in adults and can present with features of intestinal obstruction. CASE PRESENTATION: A 10year old boy presented with features of intestinal obstruction. He sustained a blunt abdominal trauma two days prior to presentation...
October 27, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27783246/hepatoprotective-and-nephroprotective-effects-of-sardinelle-sardinella-aurita-protein-hydrolysate-against-ethanol-induced-oxidative-stress-in-rats
#6
Zeineb Kamoun, Alya Sellami Kamoun, Ali Bougatef, Rim Marrakchi Kharrat, Houssem Youssfi, Tahia Boudawara, Mouna Chakroun, Moncef Nasri, Najiba Zeghal
Ethanol consumption-induced oxidative stress that is a major etiological factor has been proven to play important roles in organs' injury. In the present study, we investigated the protective effect of fish protein hydrolysate prepared from the heads and viscera of sardinelle (Sardinella aurita) (SPH) against the toxicity of ethanol on the liver and kidney of adult male rats. Animals were divided into four groups of six animals each: group C served as control, group Eth received 30 % ethanol solution at the dose of 3 g/kg body weight, group SPH received only 7...
October 25, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27765570/alkaline-proteases-from-a-newly-isolated-micromonospora-chaiyaphumensis-s103-characterization-and-application-as-a-detergent-additive-and-for-chitin-extraction-from-shrimp-shell-waste
#7
Samiha Mhamdi, Naourez Ktari, Sawssen Hajji, Moncef Nasri, Alya Sellami Kamoun
The present study was undertaken to characterize the extracellular thermostable serine alkaline proteases from newly actinomycete strain Micromonospora chaiyaphumensis S103 and to describe their evaluation in commercial detergents and shrimp waste deproteinization. This proteolytic crude extract was active and stable in alkaline solution. It was extremely stable in the pH range of 5.0-12.0. The optimum pH and temperature were 8.0 and 70°C, respectively, using casein as a substrate. The thermoactivity and thermostability of proteases were enhanced by the addition of 5mM Ca(2+)...
October 17, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27715467/molecular-identification-and-nanoremediation-of-microbial-contaminants-in-algal-systems-using-untreated-wastewater
#8
Alya Limayem, Francisco Gonzalez, Andrew Micciche, Edward Haller, Bina Nayak, Shyam Mohapatra
Wastewater-algal biomass is a promising option to biofuel production. However, microbial contaminants constitute a substantial barrier to algal biofuel yield. A series of algal strains, Nannochloris oculata and Chlorella vulgaris samples (n = 30), were purchased from the University of Texas, and were used for both stock flask cultures and flat-panel vertical bioreactors. A number of media were used for isolation and differentiation of potential contaminants according to laboratory standards (CLSI). Conventional PCR amplification was performed followed by 16S rDNA sequencing to identify isolates at the species level...
December 2016: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/27711034/real-time-monitoring-of-vaccination-campaign-performance-using-mobile-phones-nepal-2016
#9
David H Oh, Alya Dabbagh, James L Goodson, Peter M Strebel, Sanjita Thapa, Jagat Narain Giri, Sagar Ratna Shakya, Sudhir Khanal
In 2012, the Global Vaccine Action Plan* established a goal to achieve measles and rubella elimination in five of the six World Health Organization (WHO) regions (194 countries) by 2020 (1). Measles elimination strategies aim to achieve ≥95% coverage with 2 routine doses of measles-containing vaccine (2), and implement supplementary immunization activities (SIAs)(†) in settings where routine coverage is low or where there are subpopulations at high risk. To ensure SIA quality and to achieve ≥95% SIA coverage nationally, rapid convenience monitoring (RCM) is used during or immediately after SIAs (3,4)...
October 7, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27698041/evaluating-dispersion-forces-for-optimization-of-van-der-waals-complexes-using-a-non-empirical-functional
#10
Alya A Arabi
Modelling dispersion interactions with traditional density functional theory (DFT) is a challenge that has been extensively addressed in the past decade. The exchange-dipole moment (XDM), among others, is a non-empirical add-on dispersion correction model in DFT. The functional PW86+PBE+XDM for exchange, correlation and dispersion, respectively, compromises an accurate functional for thermochemistry and for van der Waals (vdW) complexes at equilibrium and non-equilibrium geometries. To use this functional in optimizing vdW complexes, rather than computing single point energies, it is necessary to evaluate accurate forces...
November 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27582084/kcna4-deficiency-leads-to-a-syndrome-of-abnormal-striatum-congenital-cataract-and-intellectual-disability
#11
Namik Kaya, Maysoon Alsagob, Maria Cristina D'Adamo, Albandary Al-Bakheet, Sonia Hasan, Maria Muccioli, Faten B Almutairi, Rawan Almass, Mazhor Aldosary, Dorota Monies, Osama M Mustafa, Banan Alyounes, Rosan Kenana, Jawaher Al-Zahrani, Eva Naim, Faisal S Binhumaid, Alya Qari, Fatema Almutairi, Brian Meyer, Timothy F Plageman, Mauro Pessia, Dilek Colak, Mohammed Al-Owain
BACKGROUND: Voltage-gated potassium channels are highly diverse proteins representing the most complex class of voltage-gated ion channels from structural and functional perspectives. Deficiency of these channels usually results in various human disorders. OBJECTIVES: To describe a novel autosomal recessive syndrome associated with KCNA4 deficiency leading to congenital cataract, abnormal striatum, intellectual disability and attention deficit hyperactivity disorder...
August 31, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27551721/correction-type-2-diabetes-risk-allele-loci-in-the-qatari-population
#12
Sarah L O'Beirne, Jacqueline Salit, Juan L Rodriguez-Flores, Michelle R Staudt, Charbel Abi Khalil, Khalid A Fakhro, Amal Robay, Monica D Ramstetter, Iman K Al-Azwani, Joel A Malek, Mahmoud Zirie, Amin Jayyousi, Ramin Badii, Ajayeb Al-Nabet Al-Marri, Maria J Chiuchiolo, Alya Al-Shakaki, Omar Chidiac, Maey Gharbiah, Abdulbari Bener, Dora Stadler, Neil R Hackett, Jason G Mezey, Ronald G Crystal
[This corrects the article DOI: 10.1371/journal.pone.0156834.].
2016: PloS One
https://www.readbyqxmd.com/read/27533015/cellular-barcoding-links-b-1a-b-cell-potential-to-a-fetal-hematopoietic-stem-cell-state-at-the-single-cell-level
#13
Trine A Kristiansen, Elin Jaensson Gyllenbäck, Alya Zriwil, Tomas Björklund, Jeremy A Daniel, Ewa Sitnicka, Shamit Soneji, David Bryder, Joan Yuan
Hematopoietic stem cells (HSCs) undergo a functional switch in neonatal mice hallmarked by a decrease in self-renewing divisions and entry into quiescence. Here, we investigated whether the developmental attenuation of B-1a cell output is a consequence of a shift in stem cell state during ontogeny. Using cellular barcoding for in vivo single-cell fate analyses, we found that fetal liver definitive HSCs gave rise to both B-1a and B-2 cells. Whereas B-1a potential diminished in all HSCs with time, B-2 output was maintained...
August 16, 2016: Immunity
https://www.readbyqxmd.com/read/27513806/natural-variation-in-maternal-sensitivity-is-reflected-in-maternal-brain-responses-to-infant-stimuli
#14
Alya Elmadih, Ming Wai Wan, Darragh Downey, Rebecca Elliott, James E Swain, Kathryn M Abel
Increasing evidence suggests that discrete neural networks that mediate emotion processing are activated when mothers respond to infant's images or cries. Accumulating data also indicate that natural variation in maternal caregiving behavior is related to maternal oxytocin (OT) levels. However, brain activation to infant cues has not been studied comparing mothers at disparate ends of the "maternal sensitivity" spectrum. Based on observed mother-infant play interaction at 4-6 months postpartum in 80 antenatally recruited mothers, 15 mothers with the highest sensitivity (HSMs) and 15 mothers with the lowest sensitivity (LSMs) were followed at 7-9 months using functional magnetic resonance imaging (fMRI) to examine brain responses to viewing videos of their "own" versus an "unknown" infant in 3 affect states (neutral, happy, and sad)...
October 2016: Behavioral Neuroscience
https://www.readbyqxmd.com/read/27493799/determinants-of-deescalation-failure-in-critically-ill-patients-with-sepsis-a-prospective-cohort-study
#15
Nawal Salahuddin, Lama Amer, Mini Joseph, Alya El Hazmi, Hassan Hawa, Khalid Maghrabi
Introduction. Deescalation refers to either discontinuation or a step-down of antimicrobials. Despite strong recommendations in the Surviving Sepsis Guidelines (2012) to deescalate, actual practices can vary. Our objective was to identify variables that are associated with deescalation failure. Methods. In this prospective study of patients with sepsis/septic shock, patients were categorized into 4 groups based on antibiotic administration: no change in antibiotics, deescalation, escalation (where antibiotics were changed to those with a broader spectrum of antimicrobial coverage), or mixed changes (where both escalation to a broader spectrum of coverage and discontinuation of antibiotics were carried out)...
2016: Critical Care Research and Practice
https://www.readbyqxmd.com/read/27486213/-1-3-%C3%AE-d-glucan-in-bronchoalveolar-lavage-of-lung-transplant-recipients-for-the-diagnosis-of-invasive-pulmonary-aspergillosis
#16
Archana Bhaskaran, Dima Kabbani, Lianne G Singer, Taisa Prochnow, Alya Bhimji, Coleman Rotstein, Malcolm A Finkelman, Shaf Keshavjee, Shahid Husain
(1,3) β-D-Glucan (BDG) is present in the cell wall of most fungi. Its detection in serum has been useful in the diagnosis of invasive aspergillosis (IA) in patients with hematologic malignancies. However, assaying for BDG did not perform well in the serum of lung transplant recipients. We undertook to study the performance of BDG in the bronchoalveolar lavage (BAL) of lung transplant recipients for the diagnosis of invasive pulmonary aspergillosis (IPA). Available and stored BAL samples from lung transplant recipients at the Toronto General Hospital between October 2007 and April 2013 were tested for BDG using the Fungitell kit from the Associates of Cape Cod Inc, Falmouth, MA, USA...
August 2, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27408750/the-qatar-genome-a-population-specific-tool-for-precision-medicine-in-the-middle-east
#17
Khalid A Fakhro, Michelle R Staudt, Monica Denise Ramstetter, Amal Robay, Joel A Malek, Ramin Badii, Ajayeb Al-Nabet Al-Marri, Charbel Abi Khalil, Alya Al-Shakaki, Omar Chidiac, Dora Stadler, Mahmoud Zirie, Amin Jayyousi, Jacqueline Salit, Jason G Mezey, Ronald G Crystal, Juan L Rodriguez-Flores
Reaching the full potential of precision medicine depends on the quality of personalized genome interpretation. In order to facilitate precision medicine in regions of the Middle East and North Africa (MENA), a population-specific genome for the indigenous Arab population of Qatar (QTRG) was constructed by incorporating allele frequency data from sequencing of 1,161 Qataris, representing 0.4% of the population. A total of 20.9 million single nucleotide polymorphisms (SNPs) and 3.1 million indels were observed in Qatar, including an average of 1...
2016: Human Genome Variation
https://www.readbyqxmd.com/read/27383215/type-2-diabetes-risk-allele-loci-in-the-qatari-population
#18
Sarah L O'Beirne, Jacqueline Salit, Juan L Rodriguez-Flores, Michelle R Staudt, Charbel Abi Khalil, Khalid A Fakhro, Amal Robay, Monica D Ramstetter, Iman K Al-Azwani, Joel A Malek, Mahmoud Zirie, Amin Jayyousi, Ramin Badii, Ajayeb Al-Nabet Al-Marri, Maria J Chiuchiolo, Alya Al-Shakaki, Omar Chidiac, Maey Gharbiah, Abdulbari Bener, Dora Stadler, Neil R Hackett, Jason G Mezey, Ronald G Crystal
BACKGROUND: The prevalence of type 2 diabetes (T2D) is increasing in the Middle East. However, the genetic risk factors for T2D in the Middle Eastern populations are not known, as the majority of studies of genetic risk for T2D are in Europeans and Asians. METHODS: All subjects were ≥3 generation Qataris. Cases with T2D (n = 1,124) and controls (n = 590) were randomly recruited and assigned to the 3 known Qatari genetic subpopulations [Bedouin (Q1), Persian/South Asian (Q2) and African (Q3)]...
2016: PloS One
https://www.readbyqxmd.com/read/27367659/dyeing-of-polyester-with-disperse-dyes-part-2-synthesis-and-dyeing-characteristics-of-some-azo-disperse-dyes-for-polyester-fabrics
#19
Alya M Al-Etaibi, Huda S Alnassar, Morsy Ahmed El-Apasery
The goal of this study was to utilize carrier for accelerating the rate of dyeing not only to enhance dyeing of polyester fabrics dyed with disperse dyes 3a,b, but also to save energy. Both the color strength expressed as dye uptake and the fastness properties of the dyed fabrics were evaluated.
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27349861/large-intragenic-krt1-deletion-underlying-atypical-autosomal-dominant-keratinopathic%C3%A2-ichthyosis
#20
Takuya Takeichi, Lu Liu, Alya Abdul-Wahab, James R McMillan, Kristina L Stone, Masashi Akiyama, Michael A Simpson, Maddy Parsons, Jemima E Mellerio, John A McGrath
No abstract text is available yet for this article.
October 2016: Journal of Investigative Dermatology
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