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Osteoradionecrosis

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https://www.readbyqxmd.com/read/29224060/differences-between-osteoradionecrosis-and-medication-related-osteonecrosis-of-the-jaw
#1
Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori
PURPOSE: The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases. METHODS: We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed...
December 9, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29174551/surgical-management-of-severe-osteoradionecrosis-of-the-mandibular-bone-by-using-double-free-flap-reconstruction
#2
Niklas Rommel, Marco Rainer Kesting, Nils Hagen Rohleder, Klaus-Dietrich Wolff, Jochen Weitz
PURPOSE: Osteoradionecrosis (ORN) of the jaws represents one of the most severe complications after primary or adjuvant radiation therapy (RT) of large head and neck tumors. In advanced ORN cases, surgical management is generally considered the therapy of choice. However, in several severe ORN patients with extensive bone and soft tissue defects, functional and aesthetic reconstruction represents a huge challenge for any surgeon, with an increased risk of post-operative wound healing disorders...
November 2, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29172327/head-and-neck-cancer-patients-%C3%A2-information-for-the-general-dental-practitioner
#3
Jennifer Noone, Craig Barclay
Salivary gland damage is the most common adverse effect associated with radiation therapy to the head and neck. A combination of hyposalivation and dietary changes, with a reduced emphasis on oral hygiene practices can contribute to a massive increase in a person’s caries risk status. This can be further complicated by limited mouth opening. To enable optimal dental care for head and neck cancer patients before, during and after radiation therapy, patients must be informed and educated about the potential risks of dental caries and the preventive strategies available...
March 2017: Dental Update
https://www.readbyqxmd.com/read/29157550/imaging-of-radiation-and-medication-related-osteonecrosis
#4
REVIEW
Sanjay M Mallya, Sotirios Tetradis
Osteonecrosis is the devitalization of bone and consequent lytic changes. In the jaws, osteonecrosis is a pathologic consequence of prior radiation therapy (osteoradionecrosis) or certain antiresorptive medications. Herein, we review the pathogenesis and clinical manifestations of these lesions, and describe the spectrum of radiologic findings in these conditions, and highlight the similarities and differences between the imaging appearances of these 2 entities.
January 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29149496/predictive-factors-for-osteoradionecrosis-of-the-jaws-a-retrospective-study
#5
Hans P Sathasivam, Gareth R Davies, Nicholas M Boyd
BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. METHODS: A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors...
November 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/29140591/preventive-effects-of-tonsil-derived-mesenchymal-stem-cells-on-osteoradionecrosis-in-a-rat-model
#6
Hae Sang Park, Jihae Lee, Jin-Woo Kim, Ha Young Kim, Soo Yeon Jung, Sung Min Lee, Chan Hum Park, Han Su Kim
BACKGROUND: The purpose of this study was to investigate the effects of tonsil-derived mesenchymal stem cells (MSCs) on osteoradionecrosis (ORN). METHOD: We generated a mandibular ORN rat model using a combination of 20-Gy single-dose irradiation and tooth extraction. Study groups were negative control (tooth extraction only), ORN group (irradiation, tooth extraction), Matrigel-1 group (Matrigel; BD Biosciences, San Jose, CA; irradiation, Matrigel application immediately after tooth extraction), tonsil-derived MSC-1 group (irradiation, tonsil-derived MSC application immediately after tooth extraction), Matrigel-4 group (irradiation, Matrigel application 4 weeks after tooth extraction), and tonsil-derived MSC-4 group (irradiation, tonsil-derived MSC application 4 weeks after tooth extraction)...
November 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/29140581/comparison-of-long-term-outcomes-between-pull-through-resection-and-mandibular-lip-split-surgery-for-t4a-tongue-floor-of-mouth-cancers
#7
Shih-Jung Cheng, Hui-Hsin Ko, Jang-Jaer Lee, Sang-Heng Kok
BACKGROUND: The purpose of this study was to determine whether the pull-through resection is better than the mandibular lip-split for advanced tongue/floor of mouth (FOM) cancers, which remains inconclusive. METHODS: A retrospective cohort study was performed on 91 patients with T4a tongue/FOM cancers from 2009 to 2014. Cases with mandibular resection were excluded. The pull-through resection was used when the mouth opening was ≥15 mm; otherwise the mandibular lip-split was used...
November 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/29126490/dental-management-of-patients-who-have-undergone-oral-cancer-therapy
#8
REVIEW
Alessandro Villa, Sunday O Akintoye
Oral cancer therapies are associated with orofacial complications that could result in dose-limiting cancer treatment and consequent suboptimal tumor control. Oral cancer treatment complications include oral mucositis, salivary gland hypofunction, odontogenic infections, pain, dermatitis, neurotoxicity, soft tissue fibrosis, trismus, osteoradionecrosis, and potential cancer recurrence. These complications significantly affect cancer survivorship, quality of life, and psychosocial status. Effective dental management of patients with oral cancer involves the coordination of care among several health care professionals before, during, and after cancer therapy...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29126489/dental-treatment-planning-for-the-patient-with-oral-cancer
#9
REVIEW
Lauren E Levi, Rajesh V Lalla
Oral cancer therapy is associated with a multitude of head and neck sequelae that includes, but is not limited to, hyposalivation, increased risk for dental caries, osteoradionecrosis of the jaw, radiation fibrosis syndrome, mucositis, chemotherapy-induced neuropathy, dysgeusia, dysphagia, mucosal lesions, trismus, and infections. Preparing a comprehensive treatment plan for patients undergoing cancer therapy is essential to help minimize their risks for developing these oral and dental complications. In addition, dentists must take into account a patient's ongoing oncologic therapy for those patients who present to the dentist while concurrently receiving cancer treatment...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29123273/in-vivo-imaging-of-the-microvasculature-of-the-soft-tissue-margins-of-osteonecrotic-jaw-lesions
#10
P Bastos, V Patel, F Festy, N Hosny, R J Cook
Introduction Given the increasing incidence of medication-related jaw osteonecrosis, and recognition of the mucosal blood supply's importance, we have developed a non-invasive Real Time Optical Vascular Imaging (RTOVI) instrument. Imaging the red blood cells within the sub-mucosal capillary networks demonstrates the microcirculatory anatomy. We report a small trial, demonstrating the technique's viability, examining mucosal microcirculatory changes adjacent to osteonecrotic lesions.Aims Imaging the microvasculature of soft tissue margins of patients' exposed necrotic bone lesions in situ was intended to provide unique observational as well as quantitative data, using an image analysis routine, based on ImageJ software...
November 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29123016/the-use-of-hyperbaric-oxygen-for-the-prevention-and-management-of-osteoradionecrosis-of-the-jaw-a-dana-farber-brigham-and-women-s-cancer-center-multidisciplinary-guideline
#11
Ahmed Sultan, Glenn J Hanna, Danielle N Margalit, Nicole Chau, Laura A Goguen, Francisco M Marty, Guilherme Rabinowits, Jonathan D Schoenfeld, Stephen T Sonis, Tom Thomas, Roy B Tishler, Nathaniel S Treister, Alessandro Villa, Sook-Bin Woo, Robert Haddad, Hani Mawardi
No abstract text is available yet for this article.
November 2017: Oncologist
https://www.readbyqxmd.com/read/29103566/osteoradionecrosis-a-review-of-pathophysiology-prevention-and-pharmacologic-management-using-pentoxifylline-%C3%AE-tocopherol-and-clodronate
#12
REVIEW
Jose Antonio Rivero, Omar Shamji, Antonia Kolokythas
A significant complication of radiotherapy to the head and neck for cancer treatment is osteoradionecrosis (ORN) of the jaws. The management of ORN can be complex and often requires a multimodality approach. Nonsurgical treatments with or without adjunct measures and surgical interventions have all been employed on the basis of staging of the disease process. New theories on the pathophysiology of ORN have led to the identification of novel treatment modalities, including pharmacologic management using pentoxifylline, tocopherol, and clodronate (together referred to as "Pentoclo")...
November 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29101582/most-cited-publications-in-oral-and-maxillofacial-surgery-a-bibliometric-analysis
#13
Nawaf Aslam-Pervez, Joshua E Lubek
BACKGROUND: Citation is one of the most important forms of acknowledgment and recognition received by our peers in academia. This study identifies and characterizes the current topmost highly cited publications in journals specifically dedicated to the specialty. The purpose of this study is to identify, using the citation count, works that have made key contributions in the field and to provide insight into the direction the specialty has taken in the last 30 years. METHODS: Four journals that were dedicated to the field of oral and maxillofacial surgery (OMFS) were selected...
November 4, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29090383/patients-with-advanced-periodontal-disease-before-intensity-modulated-radiation-therapy-are-prone-to-develop-bone-healing-problems-a-2-year-prospective-follow-up-study
#14
Jennifer M Schuurhuis, Monique A Stokman, Max J H Witjes, Harry Reintsema, Johannes A Langendijk, Arjan Vissink, Frederik K L Spijkervet
PURPOSE: Intensity-modulated radiation therapy (IMRT) has changed radiation treatment of head and neck cancer (HNC). However, it is still unclear if and how IMRT changes oral morbidity outcomes. In this prospective study, we assessed the outcome of reducing post-IMRT sequelae by means of pre-radiation dental screening and eliminating oral foci. METHODS: All consecutive dentate patients > 18 years, diagnosed with primary oral or oropharyngeal carcinoma, referred for pre-treatment dental screening between May 2011 and May 2013, were included and followed for 2 years...
October 31, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29089739/prophylactic-use-of-pentoxifylline-and-tocopherol-in-patients-undergoing-dental-extractions-following-radiotherapy-for-head-and-neck-cancer
#15
Karun Aggarwal, Manish Goutam, Madhavi Singh, Neetu Kharat, Vandana Singh, Suyash Vyas, Harkanwal Preet Singh
BACKGROUND: In head and neck cancer patients undergoing radiotherapy, osteoradionecrosis (ORN) of the jaw is one of the major but uncommon complications. Satisfactorily results have been observed while treating ORN patients with upcoming treatment modalities such as combination therapy of pentoxifylline and Vitamin E (PVe). It is believed that in patients undergoing dental extractions, these treatment modalities can be used prophylactically for lowering the risk of development of ORN...
July 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29071801/common-oral-complications-of-head-and-neck-cancer-radiation-therapy-mucositis-infections-saliva-change-fibrosis-sensory-dysfunctions-dental-caries-periodontal-disease-and-osteoradionecrosis
#16
REVIEW
Herve Y Sroussi, Joel B Epstein, Rene-Jean Bensadoun, Deborah P Saunders, Rajesh V Lalla, Cesar A Migliorati, Natalie Heaivilin, Zachary S Zumsteg
Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy include but are not limited to an increased susceptibility to dental caries and periodontal disease. They also include profound and often permanent functional and sensory changes involving the oral soft tissue. These changes range from oral mucositis experienced during and soon after treatment, mucosal opportunistic infections, neurosensory disorders, and tissue fibrosis...
October 25, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28990255/role-of-surgery-in-the-treatment-of-osteoradionecrosis-and-its-complications-after-radiotherapy-for-nasopharyngeal-carcinoma
#17
Wen Bo Huang, Stanley Thian Sze Wong, Jimmy Yu Wai Chan
BACKGROUND: The purpose of this study was to review the efficacy of surgery for patients with osteoradionecrosis (ORN) after radiotherapy for nasopharyngeal carcinoma (NPC). METHODS: Between 2000 and 2016, we identified 162 patients with skull base ORN, among which 58 patients required surgery. A retrospective medical chart review was performed and the indications and results of surgical interventions were recorded. RESULTS: All surgeries were performed for the treatment of secondary complications of ORN, including central nervous system (CNS) infection (48...
October 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28961429/synchronous-reconstruction-of-a-total-mandibulectomy-defect-with-a-single-fibula-osteocutaneous-free-flap
#18
Ramzey Tursun, J Marshall Green, Daniel Winokur, Andre Ledoux
Osteoradionecrosis (ORN) is a well-known and usually late complication of radiation therapy in the treatment of head and neck cancer. Although the therapy can be life extending, it also produces tissue toxicity in ipsilateral and contralateral tissues in an acute and chronic fashion. In the most severe cases of ORN, such as the one presented in this report, bilateral disease results in the need for total mandibulectomy and creates a tremendous reconstructive challenge. The advent of microvascular surgery and free tissue transfer has caused an evolution of the management protocol for severe ORN cases...
September 8, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28951870/heterogeneity-of-necrotic-changes-between-cortical-and-cancellous-bone-in-mandibular-osteoradionecrosis-a-histopathological-analysis-of-resection-margin-after-segmental-mandibulectomy
#19
Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Shungo Furudoi, Hiroto Terashi, Takahide Komori
BACKGROUND: This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. METHODS: Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneous free fibula flap reconstruction for advanced osteoradionecrosis were analyzed histopathologically for the presence of necrotic bone based on the presence of blood vessels within Haversian canals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28929077/late-temporal-lobe-extensive-osteoradionecrosis-post-radiation-for-nasopharyngeal-carcinoma-case-series
#20
Chian Ling Tang, Ramesh Kumar, Charng Jeng Toh, Shahizon Azura, Geok Chin Tan, Balwant Singh Gendeh
Osteoradionecrosis is one of the most serious complications of radiotherapy for nasopharyngeal carcinoma. We report three cases of osteoradionecrosis in temporal lobe who presented differently few years after completion of radiotherapy. Cranial magnetic resonance image showed lesions in temporal lobe either unilateral or bilateral with mass effect. One of the cases even showed disease progression few years after the initial diagnosis of osteoradionecrosis. Diagnosis of osteoradionecrosis for all three patients was confirmed by biopsy...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
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