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Osteoradionecrosis

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https://www.readbyqxmd.com/read/27913719/surgical-site-infections-in-major-head-and-neck-surgeries-involving-pedicled-flap-reconstruction
#1
Neerav Goyal, Bharat B Yarlagadda, Daniel G Deschler, Kevin S Emerick, Derrick T Lin, Debbie L Rich, James W Rocco, Marlene L Durand
OBJECTIVE: To evaluate surgical site infections (SSI) after pedicled reconstruction in head and neck surgery. METHODS: Records of patients with pedicled flap reconstructions between 2009 and 2014 at Massachusetts Eye and Ear were reviewed. Onset of SSI or fistula ≤30 days postoperatively was noted. A free flap cohort was reviewed for comparison. RESULTS: Two hundred and eight pedicled reconstructions were performed for cancer (83%), osteoradionecrosis (7%), and other reasons (10%)...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27861470/-mandibular-osteoradionecrosis-orn-as-a-side-effect-of-head-and-neck-cancer-treatment-factors-that-induce-it
#2
José Francisco Gallegos-Hernández, Alejandro Reyes-Vivanco, Héctor Arias-Ceballos, Gerardo Gabriel Minauro-Muñoz, Alma Lilia Ortiz-Maldonado, Daniel Israel García-Ruiz, Martín Hernández-Sanjuán
INTRODUCTION: Osteoradionecrosis of the mandible is a relatively common complication in patients with head and neck cancer undergoing radiotherapy or concomitant chemoradiotherapy, characterized by exposure of the mandibular bone either in the mouth or in the facial skin, with no improvement with conservative treatment for six months. The risk factors are radiotherapy in head and neck region, lack of dental prophylaxis before treatment and dental extraction. MATERIAL AND METHODS: Retrospective observational study analyzing incidence and etiologic factors of osteoradionecrosis in 250 patients undergoing radiotherapy or combined treatment of cervicofacial area between 2002 and 2010...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27823650/osteoradionecrosis-and-intensity-modulated-radiation-therapy-an-overview
#3
REVIEW
Francesca De Felice, Daniela Musio, Vincenzo Tombolini
Osteoradionecrosis (ORN) is an ongoing topic, especially about its definition, pathogenesis, staging system and management algorithm. But what about its real incidence in intensity modulated radiotherapy (IMRT) era? This paper discusses the mandible in radiation therapy planning as organ at risk and reviews the literature for evidence of radiation damage, discussing likely dose constraints and the use of IMRT to reduce radiation dose to this structure. PubMed search was performed.
November 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27812692/radiotherapy-characteristics-and-outcomes-for-head-and-neck-carcinoma-of-unknown-primary-vs-t1-base-of-tongue-carcinoma
#4
Ali Hosni, Peter R Dixon, Anupam Rishi, Michael Au, Wei Xu, Yuyao Song, Douglas B Chepeha, David P Goldstein, Shao Hui Huang, John Kim, Brian O'Sullivan, John Waldron, Scott V Bratman, John R de Almeida
Importance: Transoral robotic surgery- or transoral laser microsurgery-assisted lingual tonsillectomy may improve the identification rate of hidden base-of-tongue (BOT) carcinoma presenting as head or neck carcinoma of unknown primary (CUP) site. Objective: To evaluate the potential impact of lingual tonsillectomy in CUP site by comparing differences in radiotherapy volumes, dosimetry, and clinical outcomes for CUP site and T1-category BOT carcinoma. Design, Setting, and Participants: Retrospective study of 115 patients treated at a tertiary cancer center between January 1, 2005, and December 31, 2013, that included patients with BOT carcinoma (category T1N1-3M0) and CUP site (category T0N1-3M0) with known p16 status...
November 3, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27809693/clinical-outcome-and-health-related-quality-of-life-following-microsurgical-reconstruction-in-patients-with-oral-and-oropharyngeal-cancer
#5
Shems Al-Hayder, Jens Jørgen Elberg, Birgitte Charabi
CONCLUSION: Radial forearm free flap (RFFF) and fibula free flap (FFF) provide high safety and reliability with low incidence of free flap failure and an acceptable level of complications and health-related quality-of-life (HRQoL). OBJECTIVES: To determine the clinical outcomes and long-term HRQoL in patients with oral or oropharyngeal cancer following free flap reconstruction. METHODS: A retrospective review of medical records and self-administered HRQoL questionnaires, EORTC QLQ-C30, and -H&N35...
November 4, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27771829/a-retrospective-study-of-osteomyelitis-and-osteonecrosis-of-the-jaws-and-its-etiologic-implication-of-bisphosphonate-in-asians
#6
Sung Ok Hong, Chae-Yoon Lee, Junho Jung, Deog-Yoon Kim, Christian Walter, Yong-Dae Kwon
OBJECTIVE: The objective of this study were to find the annual case trend of inflammatory jawbone diseases and to investigate the impact of medication-related osteonecrosis of the jaws (MRONJ). MATERIAL AND METHODS: A retrospective study of 372 patients diagnosed with inflammatory jawbone condition except for alveolar osteitis from 2007 to 2015 was initiated. History taking and investigation of etiologic factors MRONJ, osteoradionecrosis (ORN), odontogenic infection, foreign body, and trauma were investigated...
October 22, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27747703/a-case-of-peri-implantitis-and-osteoradionecrosis-arising-around-dental-implants-placed-before-radiation-therapy
#7
Yuji Teramoto, Hiroshi Kurita, Takahiro Kamata, Hitoshi Aizawa, Nobuhiko Yoshimura, Humihiro Nishimaki, Kazunobu Takamizawa
A little is known about the effect of radiotherapy on the dental implants that have previously been osseointegrated and charged. Here, we reported a case of osteoradionecrosis which arose around dental implants placed before radiation therapy.
December 2016: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27734822/the-side-effects-of-head-and-neck-tumors-radiotherapy
#8
Marta Skiba-Tatarska, Marta Kusa-Podkańska, Anna Surtel, Joanna Wysokińska-Miszczuk
Radiotherapy of head and neck tumours causes numerous complications in the oral cavity. The most frequent side effects are: mucositis, osteoradionecrosis, hypogeusia or dysgeusia, xerostomia, dental caries, dentinal hypersensitivity. It is recomended to prevent, reduce or relieve these complications in the oral cavity.
July 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27713052/accuracy-of-virtually-3d-planned-resection-templates-in-mandibular-reconstruction
#9
Willem L J Weijs, Casper Coppen, Ruud Schreurs, Rinaldo D Vreeken, Arico C Verhulst, Matthias A W Merkx, Stefaan J Bergé, Thomas J J Maal
OBJECTIVE: Since reconstruction of composite defects in the head and neck region is a challenging and demanding problem for head and neck surgeons, surgical aids have been sought for decades. The purpose of this study was to evaluate the accuracy of prefabricated surgical resection templates used in mandibular segmental resections in comparison to the virtual surgical plan. MATERIALS AND METHODS: A prospective study was performed in 11 consecutive patients, with a primary T4 oral squamous cell carcinoma or osteoradionecrosis of the mandible...
November 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27688724/radiation-induced-caries-as-the-late-effect-of-radiation-therapy-in-the-head-and-neck-region
#10
REVIEW
Katarzyna Dobroś, Justyna Hajto-Bryk, Małgorzata Wróblewska, Joanna Zarzecka
Overall improvement in the nationwide system of medical services has consequently boosted the number of successfully treated patients who suffer from head and neck cancer. It is essential to effectively prevent development of radiation-induced caries as the late effect of radiation therapy. Incidence and severity of radiationinduced changes within the teeth individually vary depending on the patient's age, actual radiation dose, size of radiation exposure field, patient's general condition and additional risk factors...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27680099/mandibular-intraosseous-pseudocarcinomatous-hyperplasia-a-case-report
#11
Andreas Fuchs, Stefan Hartmann, Karen Ernestus, Grit Mutzbauer, Christian Linz, Roman C Brands, Alexander C Kübler, Urs D A Müller-Richter
BACKGROUND: Mandibular pseudocarcinomatous hyperplasia is a rare and generally benign pathology. We report on one of these rare cases. CASE PRESENTATION: The case history of a 73-year-old white man stated that he had a carcinoma of the oropharynx, which was primarily treated with radiotherapy and chemotherapy 4 years prior. As a result of radiotherapy he developed an osteoradionecrosis of his mandible and a consecutive pathological fracture of his left mandibular angle...
September 29, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27675829/dose-volume-correlates-of-osteoradionecrosis-of-the-mandible-in-oropharynx-patients-receiving-intensity-modulated-radiation-therapy
#12
A S R Mohamed, S Y Lai, M Murri, K A Hutcheson, V C Sandulache, B Hobbs, G B Gunn, N Garg, M S Chambers, S J Frank, D I Rosenthal, A S Garden, C D Fuller
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27651287/pentoxifylline-and-tocopherol-in-the-management-of-cancer-patients-with-medication-related-osteonecrosis-of-the-jaw-an-observational-retrospective-study-of-initial-case-series
#13
Adepitan A Owosho, Cherry L Estilo, Joseph M Huryn, SaeHee K Yom
OBJECTIVE: Very few studies have evaluated the efficacy of pentoxifylline and tocopherol (PENT-E) in the management of medication-related osteonecrosis of the jaw (MRONJ), although some studies have shown the therapeutic and prophylactic benefit of PENT-E in the management of osteoradionecrosis. We report the outcomes of MRONJ managed with PENT-E in patients with metastatic bone disease or multiple myeloma. STUDY DESIGN: Seven patients diagnosed with established cases of refractory MRONJ caused by antiresorptive medications for the management of metastatic bone tumors or multiple myeloma were administered PENT-E for a mean period of 16...
October 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27641428/hyperbaric-oxygen-therapy-for-maxillary-bone-radiation-induced-injury-a-15-year-single-center-experience
#14
Haim Gavriel, Ephraim Eviatar, Rani Abu Eta
BACKGROUND: Although hyperbaric oxygen therapy (HBOT) is used to treat chronic radiation tissue injury, clinical evidence supporting its use in maxillary bone osteoradionecrosis (ORN) is lacking. Therefore, the purpose of this study was to report our results of collected patient outcomes from a single center's large experience using HBOT to treat maxillary bone ORN. METHODS: From 1999 to 2015, 21 patients received treatment for maxillary bone ORN at our center. The medical records were retrospectively reviewed for the following variables: age, sex, comorbidities, tumor stage and site, previous surgery, previous radiotherapy or chemoradiation therapy, HBOT data, response to treatment and further management...
September 19, 2016: Head & Neck
https://www.readbyqxmd.com/read/27614524/-intensity-modulated-radiotherapy-for-head-and-neck-cancer-dose-constraint-for-salivary-gland-and-mandible
#15
Y Pointreau, T Lizée, R-J Bensadoun, P Boisselier, S Racadot, J Thariat, P Graff
Intensity-modulated radiation therapy (IMRT) is the gold standard for head and neck irradiation. It allows better protection to the organs at risk such as salivary glands and mandible, and can reduce the frequency of xerostomia, trismus and osteoradionecrosis. At the time of treatment planning, the mean dose to a single parotid gland should be kept below 26Gy, the mean dose to a single submandibular gland below 39Gy, the mean dose to the mandible below 60 to 65Gy and the D2% to a single temporomandibular joint below 65Gy...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27611746/osteoradionecrosis-following-carbon-ion-radiotherapy-case-history-report-of-a-soft-palate-defect
#16
Meiko Oki, Ayako Kanazaki, Hisashi Taniguchi
Carbon ion radiotherapy, a form of charged particle radiotherapy that has been used to treat various inoperable and radio-resistant tumors, has been associated with less severe late effects than conventional radiotherapy. A 63-year-old woman with a soft palate defect received carbon ion radiotherapy (total dose: 64 Gray equivalents). Several late effects were observed, and osteoradionecrosis was observed not only on the tumor side but also on the other side and gradually expanded during maxillofacial prosthetic rehabilitation...
September 2016: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/27601399/the-osteosarcoradionecrosis-as-an-unfavorable-result-following-head-and-neck-tumor-ablation-and-microsurgical-reconstruction
#17
REVIEW
Nidal Farhan Al Deek, Fu-Chan Wei
Osteoradionecrosis is preferably called osteosarcoradionecrosis to adequately cover the scope of the problem: multitissue necrosis. The changes following radiotherapy and leading to necrosis are further classified into 2 phases based on improved understanding of the underlying mechanisms. The reversible-damage phase could respond to the medical treatment, while the irreversible damage phase or osteosarcoradionecrosis may benefit from complete resection and free flap reconstruction. The role of ablation and reconstruction in paving the road for the development of osteosarcoradionecrosis is discussed, a case study provided, and a refined reconstructive approach proposed...
October 2016: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27600691/ameliorative-effect-of-black-grape-juice-on-systemic-alterations-and-mandibular-osteoradionecrosis-induced-by-whole-brain-irradiation-in-rats
#18
Robson B Freitas, Paquita González, Nara Maria B Martins, Edson R Andrade, María Jesús Cesteros Morante, Iban Conles Picos, Serafín Costilla García, Liliane F Bauermann, Juan Pablo Barrio
PURPOSE: Whole brain irradiation (WBI) causes a variety of secondary side-effects including anorexia and bone necrosis. We evaluated the radiomodifying effect of black grape juice (BGJ) on WBI alterations in rats measuring food and water intake, body weight, hemogram, and morphological and histological mandibular parameters. MATERIALS AND METHODS: Forty male rats (200-250 g) were exposed to eight sessions of cranial X-ray irradiation. The total dose absorbed was 32 Gy delivered over 2 weeks...
October 7, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27592129/american-brachytherapy-society-task-group-report-combined-external-beam-irradiation-and-interstitial-brachytherapy-for-base-of-tongue-tumors-and-other-head-and-neck-sites-in-the-era-of-new-technologies
#19
Zoltán Takácsi-Nagy, Rafael Martínez-Mongue, Jean-Jacques Mazeron, Cristopher James Anker, Louis B Harrison
Irradiation plays an important role in the treatment of cancers of the head and neck providing a high locoregional tumor control and preservation of organ functions. External beam irradiation (EBI) results in unnecessary radiation exposure of the surrounding normal tissues increasing the incidence of side effects (xerostomy, osteoradionecrosis, and so forth). Brachytherapy (BT) seems to be the best choice for dose escalation over a short treatment period and for minimizing radiation-related normal tissue damage due to the rapid dose falloff around the source...
August 31, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27545968/minimizing-osteoradionecrosis-after-mandibular-reconstruction-and-radiation-in-advanced-head-and-neck-cancer-patients
#20
Emre Gazyakan, Chih-Wei Wu, Jung-Ju Huang, Holger Engel, Ian Lee Valerio, Ming-Huei Cheng
BACKGROUND: Osteoradionecrosis may develop on the residual mandible or reconstructed fibula because of inadequate soft tissue coverage and compromised tissue perfusion post mandibular reconstruction, and radiation. This study was to investigate the incidence of osteoradionecrosis following class III mandibular defect reconstructions with an OPAC flap versus a fibula OSC flap. METHODS: A retrospective review of a consecutive series of mandibular reconstructions between 1999 and 2010 was performed...
September 2016: Journal of Surgical Oncology
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