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https://www.readbyqxmd.com/read/29916603/-oncological-disease-dimensions-of-the-phenomenon-and-role-ionizing-radiation
#1
Giuseppe Taino, Lorenzo Bordini, Marcello Imbriani
OBJECTIVES: The continuous scientific advances against neoplastic diseases affecting all areas of oncology biomedical research. Age is an extremely important factor in cancer development, since the incidence of cancer increases significantly with age. Because of aging of the Italian population, although the incidence is kept constant, the number of cancer diagnosis is inevitably going to increase over time only to increasing age. METHODS: Survival after the diagnosis of cancer is one of the main indicators that allow to evaluate the effectiveness of the health system against the cancer disease...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916453/high-risk-factors-for-suppurative-mastitis-in-lactating-women
#2
Zhonghua Yu, Shanping Sun, Yang Zhang
BACKGROUND Acute mastitis is a common disease occurring in postpartum lactating women. This study aimed to identify the high-risk factors for suppurative mastitis (SM) in women who were breastfeeding. MATERIAL AND METHODS A total of 262 non-SM patients and 63 SM patients admitted to the Department of Breast and Thyroid Surgery of Liaocheng People's Hospital were retrospectively enrolled in this study. The high-risk factors for SM during lactation were determined by assessing admission time after acute mastitis, galactostasis, primipara or pluripara, nipple injuries, antibiotic treatment course, and diabetes...
June 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29915578/non-desmoglein-antibodies-in-patients-with-pemphigus-vulgaris
#3
REVIEW
Kyle T Amber, Manuel Valdebran, Sergei A Grando
Pemphigus vulgaris (PV) is a potentially life-threatening mucocutaneous autoimmune blistering disease. Patients develop non-healing erosions and blisters due to cell-cell detachment of keratinocytes (acantholysis), with subsequent suprabasal intraepidermal splitting. Identified almost 30 years ago, desmoglein-3 (Dsg3), a Ca2+ -dependent cell adhesion molecule belonging to the cadherin family, has been considered the "primary" autoantigen in PV. Proteomic studies have identified numerous autoantibodies in patients with PV that have known roles in the physiology and cell adhesion of keratinocytes...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29915563/immunological-profile-and-predisposition-to-autoimmunity-in-girls-with-turner-syndrome
#4
Aneta Monika Gawlik, Elzbieta Berdej-Szczot, Dorota Blat, Renata Klekotka, Tomasz Gawlik, Ewa Blaszczyk, Magdalena Hankus, Ewa Malecka-Tendera
Objective: The risk of autoimmune diseases (AD) in patients with Turner Syndrome (TS) is twice higher than in the general female population and four times higher than in the male population. The causes of the increased incidence of AD in TS are still under discussion. We hypothesized the presence of a specific humoral, cellular, and regulatory T cell (Treg) immunity profile which predisposes to AD, disorders of immunity, and disorders of immune regulation. Methods: The study encompassed 37 girls with TS and with no signs of infection...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29915201/comparative-assessment-of-graves-disease-and-main-extrathyroidal-manifestation-graves-ophthalmopathy-by-non-targeted-metabolite-profiling-of-blood-and-orbital-tissue
#5
Dong Yoon Ji, Se Hee Park, Soo Jin Park, Kyoung Heon Kim, Cheol Ryong Ku, Dong Yeob Shin, Jin Sook Yoon, Do Yup Lee, Eun Jig Lee
Graves' disease (GD) is an autoimmune disorder that causes the overproduction of thyroid hormones and consequent cascade of systemic metabolism dysfunction. Moreover, Graves' ophthalmopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). The goal of the study was to identify metabolic signatures in association with diagnostic biomarkers of GD without GO and GO, respectively. Ninety metabolites were profiled and analyzed based on a non-targeted primary metabolite profiling from plasma samples of 21 GD patients without GO, 26 subjects with GO, and 32 healthy subjects...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914903/isolated-thyroid-metastasis-from-benign-phyllodes-tumour
#6
Mark R Kho, Agustina D Abelardo
We present a rare and interesting case of a 35-year-old woman who initially underwent an uneventful wide excision for a 13 cm left benign phyllodes tumour. She then noted a slowly growing left thyroid nodule 8 months postsurgery which on thyroidectomy 4 years later was shown to be a 6.9cm isolated thyroid metastasis from the phyllodes tumour. As this may be the first reported such case in the literature, implications on histological classification, predictive factors for disease progression, mechanisms of metastasis, and evaluation, management and surveillance of benign phyllodes tumours and thyroid nodule/s with a history of phyllodes tumour can thus be significantly impacted...
June 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29914897/concurrent-metastases-of-papillary-thyroid-carcinoma-to-the-scalp-and-meckel-s-cave
#7
Patrick S Phelan, Jamie L Mull, Mohamed Z Rajput, Amy C Musiek
We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement...
June 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29914537/combination-therapy-of-ipilimumab-and-nivolumab-induced-thyroid-storm-in-a-patient-with-hashimoto-s-disease-and-diabetes-mellitus-a-case-report
#8
Kazuko Yonezaki, Toshihiro Kobayashi, Hitomi Imachi, Takuo Yoshimoto, Fumi Kikuchi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Nao Yamaji, Jingya Lyu, Tao Dong, Koji Murao
BACKGROUND: Recently, immune checkpoint inhibitors have widely been used for the management of advanced melanoma. However, high-grade immune-related adverse events can occur, particularly with combination immunotherapy. We report a case of a patient with melanoma who developed thyroid storm following treatment with ipilimumab and nivolumab. CASE PRESENTATION: An 85-year-old Japanese man with a history of malignant melanoma presented to our department with severe thyrotoxicosis and poor blood glucose control...
June 19, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29913568/a-short-review-on-human-exposure-to-and-tissue-distribution-of-per-and-polyfluoroalkyl-substances-pfass
#9
REVIEW
Jun-Meng Jian, Da Chen, Fu-Juan Han, Ying Guo, Lixi Zeng, Xingwen Lu, Fei Wang
PFASs are widely distributed in natural and living environment and can enter human bodies via different routes. Many studies have reported that PFASs may be associated with human diseases, such as urine acid and thyroid diseases. In this study, we reviewed PFAS levels in human bodies reported in past seven years, including blood, urine, milk, and tissues (hair and nails). Most studies focused on human blood. Blood type, spatiality, human age, and gender were found to have a strong relationship with PFAS levels in blood samples...
September 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29912597/cystatin-c-as-a-predictor-of-mortality-in-elderly-patients-with-chronic-kidney-disease
#10
Sebastjan Bevc, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: The prevalence of chronic kidney disease (CKD) in the elderly is high. Serum cystatin C is an accurate marker of kidney function and it also has prognostic utility in CKD patients. The aim of our study was to determine the prediction of serum cystatin C and other markers of kidney function on long-term survival in elderly CKD patients. METHODS: Fifty eight adult Caucasian patients, older than 65 years, without known malignancy, thyroid disease and/or not on steroid therapy were enrolled in the study...
June 18, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29911396/epidemiology-of-swallowing-disorders-in-rheumatoid-arthritis-prevalence-risk-factors-and-quality-of-life-burden
#11
Nelson Roy, Kristine M Tanner, Ray M Merrill, Charisse Wright, Jenny L Pierce, Karla L Miller
OBJECTIVE: This investigation examined the prevalence, symptoms, risk factors, and quality-of-life burden of swallowing disorders in rheumatoid arthritis (RA), a chronic, progressive autoimmune inflammatory disease. METHODS: One hundred individuals with RA (84 women, 16 men; mean age = 61.1 years, SD = 13.1) were interviewed regarding the presence, nature, and impact of swallowing symptoms and disorders. Associations between swallowing disorders, medical factors, RA disease severity, and quality of life were examined...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29911021/-mycobacterium-avium-subspecies-paratuberculosis-a-possible-causative-agent-in-human-morbidity-and-risk-to-public-health-safety
#12
REVIEW
Mary Garvey
Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep. Infection with this microorganism results in substantial farming economic losses and animal morbidity. The link between infection with this pathogen and human disease has been theorised for many years with Crohn's disease being one of many suspected resultant conditions. Mycobacterium avium may be spread from animal to human hosts by water and foodborne transmission routes, where the foodborne route of exposure represents a significant risk for susceptible populations, namely children and the immune-compromised...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29909599/survival-of-aggressive-variants-of-papillary-thyroid-carcinoma-in-patients-under-55-years-old-a-seer-population-based-retrospective-analysis
#13
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29908479/incident-thyroid-disease-in-female-spouses-of-private-pesticide-applicators
#14
Srishti Shrestha, Christine G Parks, Whitney S Goldner, Freya Kamel, David M Umbach, Mary H Ward, Catherine C Lerro, Stella Koutros, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler
BACKGROUND: Little is known about modifiable risk factors for thyroid disease. Several pesticides have been implicated in thyroid disruption, but clinical implications are not clear. OBJECTIVE: We assessed associations between pesticide use and other farm exposures and incident hypothyroidism and hyperthyroidism in female spouses of farmers in the Agricultural Health Study (AHS). METHODS: We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals for risk of thyroid disease in 24,092 spouses who completed at least one follow-up questionnaire...
June 13, 2018: Environment International
https://www.readbyqxmd.com/read/29907208/well-differentiated-thyroid-cancer-and-robotic-transaxillary-surgery-at-a-north-american-institution
#15
Meghan Garstka, Khuzema Mohsin, Daniah Bu Ali, Hosam Shalaby, Kareem Ibraheem, Mahmoud Farag, Sang-Wook Kang, Emad Kandil
BACKGROUND: Recent studies from Asia have reported the safety and feasibility of robotic-assisted thyroid surgery. In the United States, several small series and case reports have been published, mostly regarding treatment of benign disease. The aim of our study is to report the safety and feasibility of robotic surgery for well-differentiated thyroid cancer patients at a North American institution. MATERIALS AND METHODS: We performed a retrospective cohort study using a prospectively collected single-center clinical database at Tulane University Medical Center...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906252/pembrolizumab-for-patients-with-refractory-or-relapsed-thymic-epithelial-tumor-an-open-label-phase-ii-trial
#16
Jinhyun Cho, Hae Su Kim, Bo Mi Ku, Yoon-La Choi, Razvan Cristescu, Joungho Han, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Purpose Limited treatment options exist for patients with thymic epithelial tumor (TET) whose disease progresses after platinum-based chemotherapy. We conducted a phase II study of pembrolizumab in patients with TET to evaluate its efficacy and safety. Methods Patients with histologically confirmed TET whose disease progressed after at least one line of platinum-based chemotherapy were eligible for the study. Patients were excluded if they had an active autoimmune disease requiring systemic treatment within the past year or documented history of clinically severe autoimmune disease...
June 15, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29906034/schmidt%C3%A2-s-syndrome-a-difficult-diagnosis-in-the-latin-american-context
#17
Claudia Barreda-Velit, Rodrigo Salcedo-Pereda, Jesús Ticona
Background: Schmidt’s syndrome, also known as poliglandular autoimmune syndrome type 2, is a rare disease that has a prevalence between 1.5-4.5 cases per 100 000 inhabitants. The diagnosis consists in the concomitant presentation of Addison disease, autoimmune thyroid disease and other autoimmune endocrinological conditions. The aim of this paper is to describe a case of Schmidt’s syndrome in the peruvian context and to analyze the difficulties in the diagnosis. Clinical case: We present the case of a 43-year-old woman that presents to the emergency room with headache, nausea, vomits and a “syncope episode”...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905641/surgical-treatment-of-diplopia-in-graves-orbitopathy-patients
#18
Anja Eckstein, Joachim Esser, Michael Oeverhaus, Peerooz Saeed, Hinke Marijke Jellema
PURPOSE: To review the authors' current understanding of motility dysfunction in patients with thyroid eye disease and to summarize appropriate evaluation and available management options. METHODS: Data were retrieved from a systematic search of the literature. RESULTS: Diplopia is one of the most disabling symptoms for Graves orbitopathy patients. It occurs in moderate-to-severe Graves orbitopathy stages and does not respond well to available anti-inflammatory treatment...
June 13, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905640/imaging-investigation-of-thyroid-eye-disease
#19
Loizos C Siakallis, Jimmy M Uddin, Katherine A Miszkiel
INTRODUCTION: Thyroid eye disease (TED), is a term referring to the extrathyroidal manifestation of Grave's disease, a disorder which is currently the most common cause of hyperthyroidism and is characterised by underlying autoimmunity.The pathogenic course of the disease can be broadly classified into two stages, an early inflammatory and a late fibrotic stage. These stages are reflected in clinical severity and activity classifications, such as Clinical Activity Score and Class 0: No signs or symptoms, 1: Only signs, no symptoms (e...
June 13, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905638/the-columbia-thyroid-eye-disease-compressive-optic-neuropathy-formula
#20
Alison B Callahan, Ashley A Campbell, Susel Oropesa, Aryeh Baraban, Michael Kazim
PURPOSE: Diagnosing thyroid eye disease-compressive optic neuropathy (TED-CON) is challenging, particularly in cases lacking a relative afferent pupillary defect. Large case series of TED-CON patients and accessible diagnostic tools are lacking in the current literature. This study aims to create a mathematical formula that accurately predicts the presence or absence of CON based on the most salient clinical measures of optic neuropathy. METHODS: A retrospective case series compares 108 patients (216 orbits) with either unilateral or bilateral TED-CON and 41 age-matched patients (82 orbits) with noncompressive TED...
June 13, 2018: Ophthalmic Plastic and Reconstructive Surgery
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