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https://www.readbyqxmd.com/read/28638960/comparative-diagnostic-evaluation-of-omp31-gene-based-taqman%C3%A2-real-time-pcr-assay-with-visual-lamp-assay-and-indirect-elisa-for-caprine-brucellosis
#1
Suman Saini, V K Gupta, K Gururaj, D D Singh, R V S Pawaiya, N K Gangwar, A K Mishra, Deepak Dwivedi, Dimple Andani, Ashok Kumar, T K Goswami
Brucellosis is one of the leading causes of abortion in domestic animals that imposes costs on both economy and society. The disease is highly zoonotic and poses risk to animal handlers due to its zoonotic nature. It causes stillbirth, loss of kids and abortion in last term of pregnancy. Reproductive damage includes infertility in does and orchitis and epididymitis in breeding bucks, which result in high financial losses to farmers and the agriculture industry as a whole. It requires highly sensitive and specific assays to diagnose the disease at field level...
June 21, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28637177/brucellosis-myriad-ways-of-presentation
#2
Ashok Kumar Pannu, Vikas Suri, Kumar H Mohan, Yalala Raghavendra Rao, Savita Kumari, Subhash Varma
No abstract text is available yet for this article.
June 20, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28629726/th2-related-immune-responses-by-the-brucella-abortus-cellular-antigens-malate-dehydrogenase-elongation-factor-and-arginase
#3
Young Bin Im, Soojin Shim, Woo Bin Park, Suk Kim, Han Sang Yoo
Brucellosis is an important zoonotic disease caused by Brucella species. The disease is difficult to control due to the intracellular survival of the bacterium and the lack of precise understanding of pathogenesis. Despite of continuous researches on the pathogenesis of Brucella spp. infection, there is still question on the pathogenesis, especially earlier immune response in the bacterial infection. Malate dehydrogenase (MDH), elongation factor (Tsf), and arginase (RocF), which showed serological reactivity, were purified after gene cloning, and their immune modulating activities were then analyzed in a murine model...
June 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28624927/seroprevalence-and-risk-factors-for-bovine-brucellosis-in-domestic-yaks-bos-grunniens-in-tibet-china
#4
Jiangyong Zeng, Ciren Duoji, Zhenjie Yuan, Silang Yuzhen, Weixing Fan, Lili Tian, Chang Cai, Ian Robertson
A cross-sectional study was conducted in three counties (Damxung, Maizhokunggar and Yadong) in Tibet in April and May 2015. A total of 1,523 yaks owned by 181 herders were randomly selected and blood sampled. Sera were tested using the rose bengal test (RBT) and a competitive immune-enzymatic assay (C-ELISA) and the test results interpreted in parallel. The individual yak prevalence was 2.8% (95% CI 2.0-3.7) with a herd prevalence of 18.2% (95% CI 12.9-24.6). At the individual level, two predictor variables, age and production system, were significantly associated with seropositivity by a binary logistic regression analysis...
June 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28623676/unrecognized-pediatric-and-adult-family-members-of-children-with-acute-brucellosis
#5
Dilek Yılmaz Çiftdoğan, Selda Aslan
BACKGROUND AND AIM: Brucellosis is an infectious, contagious and zoonotic disease that occurs worldwide. The family members of an index case of brucellosis may be especially susceptible, due to sharing the same source of infection and similar risk factors for brucellosis. In this study, we propose to screen pediatric and adult family members of brucellosis index cases for detecting additional unrecognized infected family members. MATERIALS AND METHODS: 114 family members of 41 pediatric patients with brucellosis were evaluated...
June 14, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28622869/brucella-lipopolysaccharide-reinforced-salmonella-delivering-brucella-immunogens-protects-mice-against-virulent-challenge
#6
Jonathan Lalsiamthara, John Hwa Lee
Intracellular pathogen Salmonella exhibits natural infection broadly analogous to Brucella, this phenomenon makes Salmonella a pragmatic choice for an anti-Brucella vaccine delivery platform. In this study we developed and formulated a combination of four attenuated Salmonella Typhimurium live vector strains delivering heterologous Brucella antigens (rBs), namely lumazine synthase, proline racemase subunit A, lipoprotein outer membrane protein-19, and Cu-Zn superoxide dismutase. With an aim to develop a cross-protecting vaccine, Brucella pan-species conserved rBs were selected...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28616790/serological-survey-for-brucella-antibodies-in-donkeys-of-north-eastern-nigeria
#7
A O Tijjani, A U Junaidu, M D Salihu, A A Farouq, O O Faleke, S G Adamu, H I Musa, I U Hambali
A cross-sectional epidemiological study was conducted to determine seroprevalence and risk factors influencing the presence of Brucella antibodies in donkeys of Borno State, north-eastern Nigeria. The study aimed at providing baseline information that may be used in planning a control policy against equine brucellosis. Blood samples were collected from 601 donkeys, comprised of 374 males and 227 females from the six agricultural zones of the state between March 2013 and September 2014. The sera obtained were tested for Brucella antibodies using Rose Bengal plate test (RBPT) and competitive enzyme-linked immunosorbent assay (cELISA)...
June 14, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28616486/goat-farm-management-and-brucella-serological-test-among-goat-keepers-and-livestock-officers-2011-2012-nakhon-si-thammarat-province-southern-thailand
#8
Thanidtha Te-Chaniyom, Alan F Geater, Wandee Kongkaew, Usa Chethanond, Virasakdi Chongsuvivatwong
Brucellosis, a zoonotic disease particularly affecting goats, emerged in Thailand in 2003, resulting in both an occupational hazard for goat keepers and livestock officers, and production losses. Farm management practices have been identified as risk factors associated with Brucella sero-positivity in many studies. Our finding in this study should be considered in order to strengthen the system of biosecurity control in farm animals as one health approach. The objectives of the study were to describe the distribution of potential risk factors by types of goat farms and to document the prevalence of human Brucella sero-positivity among goat keepers and livestock officers in Nakhon Si Thammarat, Thailand...
December 2016: One Health
https://www.readbyqxmd.com/read/28609437/shifting-brucellosis-risk-in-livestock-coincides-with-spreading-seroprevalence-in-elk
#9
Angela Brennan, Paul C Cross, Katie Portacci, Brandon M Scurlock, William H Edwards
Tracking and preventing the spillover of disease from wildlife to livestock can be difficult when rare outbreaks occur across large landscapes. In these cases, broad scale ecological studies could help identify risk factors and patterns of risk to inform management and reduce incidence of disease. Between 2002 and 2014, 21 livestock herds in the Greater Yellowstone Area (GYA) were affected by brucellosis, a bacterial disease caused by Brucella abortus, while no affected herds were detected between 1990 and 2001...
2017: PloS One
https://www.readbyqxmd.com/read/28604602/highly-sensitive-bacteriophage-based-detection-of-brucella-abortus-in-mixed-culture-and-spiked-blood
#10
Kirill V Sergueev, Andrey A Filippov, Mikeljon P Nikolich
For decades, bacteriophages (phages) have been used for Brucella species identification in the diagnosis and epidemiology of brucellosis. Traditional Brucella phage typing is a multi-day procedure including the isolation of a pure culture, a step that can take up to three weeks. In this study, we focused on the use of brucellaphages for sensitive detection of the pathogen in clinical and other complex samples, and developed an indirect method of Brucella detection using real-time quantitative PCR monitoring of brucellaphage DNA amplification via replication on live Brucella cells...
June 10, 2017: Viruses
https://www.readbyqxmd.com/read/28604247/brucella-central-carbon-metabolism-an-update
#11
T Barbier, A Zúñiga-Ripa, S Moussa, H Plovier, J F Sternon, L Lázaro-Antón, R Conde-Álvarez, X De Bolle, M Iriarte, I Moriyón, J J Letesson
The brucellae are facultative intracellular pathogens causing brucellosis, an important zoonosis. Here, we review the nutritional, genetic, proteomic and transcriptomic studies on Brucella carbon uptake and central metabolism, information that is needed for a better understanding of Brucella virulence. There is no uniform picture across species but the studies suggest primary and/or secondary transporters for unknown carbohydrates, lactate, glycerol phosphate, erythritol, xylose, ribose, glucose and glucose/galactose, and routes for their incorporation to central metabolism, including an erythritol pathway feeding the pentose phosphate cycle...
June 12, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28602839/epidemiology-of-brucellosis-in-iran-a-comprehensive-systematic-review-and-meta-analysis-study
#12
REVIEW
Reza Mirnejad, Faramarz Masjedian Jazi, Shayan Mostafaei, Mansour Sedighi
Brucellosis is still one of the most challenging issues for health and the economy in many developing countries such as Iran. Considering the high prevalence of brucellosis, the aim of the current study was to systematically review published data about the annual incidence rate of this infection from different parts of Iran and provide an overall relative frequency (RF) for Iran using meta-analysis. We searched several databases including PubMed, ISI Web of Science, Scopus, google scholar, IranMedex and Iranian Scientific Information Database (SID) by using the following keywords: "Brucella", "Brucellosis", "Malta fever", "Mediterranean fever", "undulant fever", "zoonosis" and "Iran" in Title/Abstract/Keywords fields...
June 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28602765/epidemiological-characteristics-of-human-brucellosis-in-hamadan-province-during-2009-2015-results-from-the-national-notifiable-diseases-surveillance-system
#13
Shahrzad Nematollahi, Erfan Ayubi, Manoochehr Karami, Salman Khazaei, Masoud Shojaeian, Reza Zamani, Kamyar Mansouri, Behzad Gholamaliee
BACKGROUND: Human brucellosis and recurrent brucellosis is an ever-increasing public health concern, especially in endemic areas like Iran. Nevertheless, little is known regarding the epidemiology and determinants of recurrent brucellosis. Therefore, the objective of this study was to investigate epidemiological patterns and potential determinants of recurrent brucellosis in Hamadan Province during the years 2009-2015. METHODS: Data on reported cases of new and recurrent brucellosis from 2009 to 2015 were obtained from the provincial Notifiable Diseases Surveillance System at Hamadan University of Medical Sciences...
June 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28584176/one-health-contributions-towards-more-effective-and-equitable-approaches-to-health-in-low-and-middle-income-countries
#14
REVIEW
S Cleaveland, J Sharp, B Abela-Ridder, K J Allan, J Buza, J A Crump, A Davis, V J Del Rio Vilas, W A de Glanville, R R Kazwala, T Kibona, F J Lankester, A Lugelo, B T Mmbaga, M P Rubach, E S Swai, L Waldman, D T Haydon, K Hampson, J E B Halliday
Emerging zoonoses with pandemic potential are a stated priority for the global health security agenda, but endemic zoonoses also have a major societal impact in low-resource settings. Although many endemic zoonoses can be treated, timely diagnosis and appropriate clinical management of human cases is often challenging. Preventive 'One Health' interventions, e.g. interventions in animal populations that generate human health benefits, may provide a useful approach to overcoming some of these challenges. Effective strategies, such as animal vaccination, already exist for the prevention, control and elimination of many endemic zoonoses, including rabies, and several livestock zoonoses (e...
July 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28576116/endovascular-treatment-of-thoracic-aortic-pseudoaneurysm-due-to-brucellosis-a-rare-case-report
#15
Shuai Wang, Qi Wang, Han Liu, Siqiao Sun, Xiwei Sun, Yang Zhang, Zhongying Wang, Zhihua Cheng
BACKGROUND: Arterial damage is a known complication of brucellosis, but the occurrence of a thoracic aortic pseudoaneurysm secondary to brucellosis has not been previously reported. CASE PRESENTATION: A 65-year-old Chinese man presented with a pseudoaneurysm in the descending segment of the thoracic aorta that caused symptoms of chest pain and intermittent fever. He was diagnosed with a thoracic aortic pseudoaneurysm secondary to brucellosis based on a positive brucella serology test (standard-tube agglutination test) and imaging examination (computed tomography angiography)...
June 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28573738/mucosal-bacterial-dissemination-in-a-rhesus-macaque-model-of-experimental-brucellosis
#16
Kasi E Russell-Lodrigue, Stephanie Z Killeen, Thomas A Ficht, Chad J Roy
Animals were experimentally infected with Brucella melitensis via aerosol. B. melitensis was cultured from the saliva and vaginal vault of infected animals, corresponding to bacterial dissemination in other target tissues. This is the first report of bacterial dissemination to these mucosal surfaces in a non-human primate model of brucellosis.
June 2, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28571803/in-brucella-selective-pressure-may-turn-some-genes-on-instead-of-default-off-position
#17
Gamal Wareth, Falk Melzer, Heinrich Neubauer
Brucellosis is a major zoonosis with worldwide prevalence; more than half a million new human cases are expected every year. The genus Brucella (B) encompasses 12 accepted nomo-species and brucellae were described as Gram negative, aerobic, non-motile and non-haemolytic facultative intracellular bacteria. The Brucella genome contains flagella-specific genes and various hemolysins, but no flagella are formed and nor hemolysis is seen. Selective pressure can cause accumulation of mutations that turn those genes on instead of default off position and provoked the motile and hemolytic phenotypes...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28562515/secondary-hemophagocytic-lymphohistocytosis-in-a-child-with-brucellosis
#18
Esra Pekpak, Benhur Sirvan Cetin
Hemophagocytic lymphohistocytosis (HLH) is a potentially fatal hyperinflammatory syndrome that is characterized by proliferation of histiocytes and hemophagocytosis in different organs. The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high serum fasting triglyceride level or low fibrinogen level, and hemophagocytosis in the bone marrow, spleen, or lymph nodes. HLH can be classified as primary and secondary...
May 29, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28559723/endogenous-brucella-endophthalmitis-a-case-report
#19
Merih Oray, Zafer Cebeci, Nur Kir, Banu Turgut Ozturk, Lutfiye Oksuz, Ilknur Tugal-Tutkun
Brucellosis may be associated with a wide range of ophthalmic manifestations including endophthalmitis, which is a sight-threatening condition that needs to be rapidly recognized and treated to avoid permanent visual loss. A 26-year-old female with a 6-month history of vision loss in the left eye was treated with high dose systemic corticosteroids and azathioprine with an initial misdiagnosis elsewhere. A dense vitreous haze with opacities at the posterior hyaloid and a wide area of retinochoroiditis led to the diagnosis of endogenous endophthalmitis at presentation to us...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28535754/a-comprehensive-proteogenomic-study-of-the-human-brucella-vaccine-strain-104%C3%A2-m
#20
Xiaodong Zai, Qiaoling Yang, Kun Liu, Ruihua Li, Mengying Qian, Taoran Zhao, Yaohui Li, Ying Yin, Dayong Dong, Ling Fu, Shanhu Li, Junjie Xu, Wei Chen
BACKGROUND: Brucella spp. are Gram-negative, facultative intracellular pathogens that cause brucellosis in both humans and animals. The B. abortus vaccine strain 104 M is the only vaccine available in China for the prevention of brucellosis in humans. Although the B. abortus 104 M genome has been fully sequenced, the current genome annotations are not yet complete. In addition, the main mechanisms underpinning its residual toxicity and vaccine-induced immune protection have yet to be elucidated...
May 23, 2017: BMC Genomics
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