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https://www.readbyqxmd.com/read/29142204/sociospatial-structure-explains-marked-variation-in-brucellosis-seroprevalence-in-an-alpine-ibex-population
#1
Pascal Marchand, Pauline Freycon, Jean-Philippe Herbaux, Yvette Game, Carole Toïgo, Emmanuelle Gilot-Fromont, Sophie Rossi, Jean Hars
In a context of (re)emerging infectious diseases with wildlife reservoirs, understanding how animal ecology shapes epidemiology is a key issue, particularly in wild ungulates that share pathogens with domestic herbivores and have similar food requirements. For the first time in Europe, brucellosis (Brucella melitensis), a virulent zoonosis, persisted in an Alpine ibex (Capra ibex) population and was transmitted to cattle and humans. To better understand disease dynamics, we investigated the relationships between the spatial ecology of ibex and the epidemiology of brucellosis...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141333/-investigation-of-human-brucellosis-diagnosis-and-report-quality-in-medical-institutions-in-key-areas-of-shanxi-province
#2
L J Zeng, W W Yang, P Tie, X R Liu, X R Gao, Z Y Li, P Hou, Y Zhi, Y F Bai, M J Geng, Q L Chen, B Y Cui, Z J Li, L P Wang
Objective: To evaluate the accuracy of human brucellosis diagnosis and reporting in medical institutions in Shanxi province, and understand the performance of clinical doctors to diagnose human brucellosis according to diagnostic criteria. Methods: Field investigation was conducted in 6 medical institutions in the key areas of human brucellosis in Shanxi province. The diagnosis data of the reported brucellosis cases in 2015 were collected and reviewed retrospectively for the evaluation of the diagnosis accuracy with systematic sampling method...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29130123/informal-value-chain-actors-knowledge-and-perceptions-about-zoonotic-diseases-and-biosecurity-in-kenya-and-the-importance-for-food-safety-and-public-health
#3
Simon Nyokabi, Regina Birner, Bernard Bett, Linda Isuyi, Delia Grace, Denise Güttler, Johanna Lindahl
Zoonotic diseases, transmitted from animals to humans, are a public health challenge in developing countries. Livestock value chain actors have an important role to play as the first line of defence in safeguarding public health. However, although the livelihood and economic impacts of zoonoses are widely known, adoption of biosecurity measures aimed at preventing zoonoses is low, particularly among actors in informal livestock value chains in low and middle-income countries. The main objective of this study was to investigate knowledge of zoonoses and adoption of biosecurity measures by livestock and milk value chain actors in Bura, Tana River County, in Kenya, where cattle, camels, sheep and goats are the main livestock kept...
November 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29125076/-a-14-year-old-syrian-refugee-with-neurobrucellosis
#4
M S W Quaak, H H J Bavelaar, J Berkhout, G J Tuin, E M Bijker
BACKGROUND: Neurobrucellosis is a rare complication of brucellosis, a bacterial zoonotic disease endemic in regions such as the Middle East. It is important to be alert for this imported disease in the Netherlands as well, especially among migrants. CASE DESCRIPTION: A 14-year-old boy from Syria presented with headache, vomiting and weight loss. Brucella melitensis was identified in the cerebrospinal fluid. The patient's condition deteriorated despite antibiotic treatment, particularly neurologically, and imaging revealed a newly developed hydrocephalus...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29122689/spatiotemporal-analysis-of-brucellosis-incidence-in-iran-from-2011-2014-using-gis
#5
Reza Pakzad, Iraj Pakzad, Ali Janati, Mohammad Reza Shirzadi, Marzieh Mohammadpour, Abbas Behroozi, Mark J M Sullman, Saeid Safiri
BACKGROUND: To investigate the distribution and trends associated with brucellosis incidences in Iran from 2011-2014. METHODS: The reported incidences of brucellosis were collected and entered into GIS 10.1 for the period 2011-2014. The Cochran-Armitage test for linear trends, choropleth maps, hot-spot analysis, and high-low clustering analysis were used to investigate patterns of the disease over the study period and season, as well as identifying high-risk areas and any clustering of the disease...
November 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29113778/quantitative-polymerase-chain-reaction-based-quantification-of-brucella-dna-in-serum-of-pre-and-post-therapeutic-occupationally-exposed-infected-human-population
#6
S Thakur, J S Bedi, R Singh, J P S Gill, A K Arora, Neeraj Kashyap
BACKGROUND: Brucellosis is one of the neglected zoonotic diseases in humans. The serological methods based on antibody detections are unable to detect the effectiveness of treatment in humans as antibodies persist for long time in humans even after therapy. Therefore, we developed qPCR technique to overcome such discrepancy and device a rapid and efficient test for both diagnosis and follow up of the brucellosis affected individuals. METHODS: High risk suspected individuals with positive serology (RBPT, STAT and iELISA) and PCR were mainly analyzed for DNA quantification by qPCR assay...
November 4, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29110870/evidence-of-ongoing-brucellosis-in-livestock-animals-in-north-west-libya
#7
Huda H Al-Griw, Elfurgani Salem Kraim, Milad E Farhat, Lorraine L Perrett, Adrian M Whatmore
Animal brucellosis is thought to be present in small ruminants, cattle, and camels in Libya, particularly in the west coastal strip. Before the system collapsed due to political unrest in 2011, prevalence of the disease did not exceed 0.2% in cattle, 0.1% in camels, 8.3% in sheep, and 14.8% in goats. The aim of this study was to highlight outbreaks of disease that took place during the 18-month period from November 2014 to April 2016. A total of 1612 serum samples, collected opportunistically from 29 herds in 12 different localities in the northwest region of Libya, were investigated for brucellosis...
December 2017: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29103700/mlva-16-typing-of-brucella-suis-biovar-2-strains-circulating-in-europe
#8
A C Ferreira, M I Corrêa de Sá, R Dias, R Tenreiro
Swine brucellosis due to Brucella suis biovar 2 is an emerging disease in Europe, associated with increase of extensive swine farms and high density of infected wild boars. Since knowledge of predominant circulating strains is a prerequisite for any epidemiological study, accurate molecular typing procedures were applied to a collection of 176 B. suis isolates. By using suis-ladder multiplex PCR and PCR-RFLP analysis of omp2a, omp2b and omp31 genes, five haplotypes were identified among 160 biovar 2 isolates, with haplotypes 2d and 2e restricted to Portugal and Spain and haplotypes 2a, 2b and 2c widespread in Europe (except Portugal)...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29102107/the-characterization-of-brucella-strains-isolated-from-cattle-in-algeria-reveals-the-existence-of-a-b-abortus-lineage-distinct-from-european-and-sub-saharan-africa-strains
#9
Mammar Khames, Virginie Mick, M Jesús de Miguel, Guillaume Girault, Raquel Conde-Álvarez, Djamel Khelef, Mustapha Oumouna, Ignacio Moriyón, Pilar M Muñoz, Amaia Zúñiga-Ripa
Brucellosis is a zoonosis caused by bacteria of the genus Brucella that causes important economic losses and human suffering worldwide. Brucellosis control requires an understanding of the Brucella species circulating in livestock and humans and, although prevalent in African countries of the Mediterranean basin, data for this area are mostly restricted to isolates obtained from humans and small ruminants. Here, we report the characterization of twenty-four Brucella strains isolated from Algerian cattle. Bruce-ladder multiplex PCR and conventional biotyping showed that Algerian cattle are infected mostly by B...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29096717/variability-in-the-response-of-canine-and-human-dendritic-cells-stimulated-with-brucella-canis
#10
Myriam Pujol, Francisca Castillo, Carla Alvarez, Camila Rojas, Consuelo Borie, Arturo Ferreira, Rolando Vernal
Brucella canis is a small intracellular Gram-negative bacterium whose primary host is the dog, but it also can cause mild human brucellosis. One of the main causes of an inefficient immune response against other species of Brucella is their interaction with dendritic cells (DCs), which affects antigen presentation and impairs the development of an effective Th1 immune response. This study analysed the cytokine pattern production, by RT-qPCR and ELISA, in human and canine DCs against whole B. canis or its purified LPS...
November 2, 2017: Veterinary Research
https://www.readbyqxmd.com/read/29082458/high-level-of-b19-strain-detection-in-brazilian-cattle-semen
#11
M P S Lourencetti, M A Souza, M R Ganda, J P Santos, A Ferreira Júnior, S Miyashiro, A M C Lima
Semen contaminated with microorganisms can disseminate serious diseases including brucellosis. The objectives of this study were to detect Brucella-specific antibodies and Brucella abortus DNA in samples of blood and fresh semen from 100 animals older than 20 months. The samples were collected on farms and in semen collection and processing centers (CCPS). The serum samples were evaluated by Rose Bengal test (RBT). B. abortus DNA was detected by a polymerase chain reaction (PCR) using BAB and IS771 primers...
October 29, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29082252/multivalent-fusion-dna-vaccine-against-brucella-abortus
#12
Leonardo Gómez, Javiera Llanos, Emilia Escalona, Darwin Sáez, Francisco Álvarez, Raúl Molina, Manuel Flores, Angel Oñate
As an alternative brucellosis prevention method, we evaluated the immunogenicity induced by new multivalent DNA vaccines in BALB/c mice. We constructed the vaccines by fusion of BAB1_0273 and/or BAB1_0278 open reading frames (ORFs) from genomic island 3 (GI-3) and the Brucella abortus 2308 sodC gene with a link based on prolines and alanines (pV273-sod, pV278-sod, and pV273-278-sod, resp.). Results show that immunization with all tested multivalent DNA vaccines induced a specific humoral and cellular immune response...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29071584/childhood-brucellosis-in-eastern-india
#13
Devarati Dutta, Anindita Sen, Debkishore Gupta, Prabir Kuila, Debasmita Chatterjee, Sugat Sanyal, Satadal Das
OBJECTIVE: To investigate the presence of childhood brucellosis presenting as PUO (pyrexia of unknown origin) cases in Eastern zone of India. METHODS: Blood samples were collected from PUO patients aged ≤18 y. The main diagnostic tools were STAT, RBPT, ELISA- IgM, IgG and PCR. Although mainly PUO cases were selected for the study, other associated clinical manifestations were also noted. RESULTS: The findings revealed significantly higher percentage of infection in female children (14...
October 26, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29062710/brucellosis-a-cause-of-meningitis-not-to-neglect
#14
Abdelhay Lemnouer, Mohammed Frikh, Adil Maleb, Aziz Ahizoune, Ahmed Bourazza, Mostafa Elouennass
Brucellosis is the most frequent bacteria zoonosis in the world, with more than half a million new cases each year [1]. It is also the most significant zoonos in the edge of the Mediterranean Sea [2]. This zoonosis is capable of affecting humans and cause polymorphic clinical manifestations. In Morocco, the southern regions are the main affected areas [3]. We are reporting the observation of a 17-year-old male patient, who presented a febrile meningeal syndrome for 9 months without sensitivo-motor deficit. Tuberculosis is frequently evoked in such clinical presentations because Morocco is an endemic country, brucellosis is therefore often forgotten...
2017: IDCases
https://www.readbyqxmd.com/read/29055858/deletion-of-the-transcriptional-regulator-gntr-down-regulated-the-expression-of-genes-related-to-virulence-and-conferred-protection-against-wild-type-brucella-challenge-in-balb-c-mice
#15
Zhi-Qiang Li, Jin-Liang Zhang, Li Xi, Guang-Li Yang, Shu-Li Wang, Xiao-Gen Zhang, Jun-Bo Zhang, Hui Zhang
Brucellosis, which is caused by Brucella spp., is a zoonotic infectious disease that can cause great hazard to public health and safety. The virulence of Brucella is essential for survive and multiply in host macrophages. GntR is a transcriptional regulator in Brucella that is required for virulence in macrophages and mice, and involved in resistance to stress responses. To determine the expression levels of target genes of GntR, we detected the expression levels of the GntR target genes in Brucella infected BALB/c mice...
October 19, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29041788/use-of-i-brucella-abortus-i-species-specific-polymerase-chain-reaction-assay-for-the-diagnosis-of-bovine-brucellosis
#16
Songelwayo L Chisi, Tracy Schmidt, George W Akol, Henriette Van Heerden
Serology is primarily used in the diagnosis of bovine brucellosis. Bacterial culture and isolation is the gold standard in diagnosing brucellosis but, like serology, it does not offer complete (100%) diagnostic sensitivity and specificity. Polymerase chain reaction (PCR) has been suggested to offer better specificity and sensitivity. In this study, we evaluated the performance of Brucella abortus species specific (BaSS) PCR directly from different samples in the diagnosis of bovine brucellosis in naturally infected cattle in KwaZulu-Natal province of South Africa with known infectious status from culture...
September 27, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29036953/-a-clinical-analysis-of-six-patients-with-brucella-endocarditis-and-literature-review
#17
L Luo, B T Zhou, H L Wang, H T Dou, T S Li
Objective: To analyze the epidemiology and clinical characteristics of patients with Brucella endocarditis in order to improve the understanding and treatment of Brucella endocarditis. Methods: The clinical data including demographic characteristics, clinical features, laboratory data, echocardiography, treatment and clinical outcome of 6 patients with Brucella endocarditis were collected and analyzed. Results: In our database consisting of 211 brucellosis patients with positive blood culture, 6 patients (2...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29036949/-paying-more-attentions-to-diagnosis-and-treatment-of-complex-brucellosis
#18
W H Zhang
No abstract text is available yet for this article.
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29032658/analysis-of-protein-expression-in-brucella-abortus-mutants-with-different-growth-rates-by-two-dimensional-gel-electrophoresis-and-lc-ms-ms-peptide-analysis
#19
Woo Bin Park, Young Bin Im, Shim Soojin, Han Sang Yoo
Brucella abortus is a bacterium that causes brucellosis and is the causative agent of worldwide zoonosis. Pathogenesis of the Brucella abortus infection is so complicates. Thus, several researches have made to solve mechanism in infection of Brucella abortus. While several proteins are revealed as the pathogenic factors by previous researches, underlying mechanism of the Brucella abortus infection is still left to be resolved. We identify the proteins showing the different expression level in Brucella abortus mutants with different biological characteristics that generated by random insertion of transposon...
October 13, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29031243/preparation-and-evaluation-of-rifampicin-and-co-trimoxazole-loaded-nanocarrier-against-brucella-melitensis-infection
#20
Narges Bodaghabadi, Samira Hajigholami, Ziba Vaise Malekshahi, Maliheh Entezari, Farhood Najafi, Hadi Shirzad, Majid Sadeghizadeh
Background: Brucellosis or Malta fever is a contagious infection common between human and domestic animals. Many antibiotics are used for brucellosis treatment, but they are not efficient and put heavy burden on society. Co-trimoxazole and rifampicin are two candidates for brucellosis treatment. In this study, we aimed to enhance the efficacy of these antibiotics using designed nanoparticles. Methods: Different concentrations of co-trimoxazole and rifampicin were used for loading onto a nanostructure of synthesized monomethoxy poly(ethylene glycol)-oleate (mPEG-OA)...
October 15, 2017: Iranian Biomedical Journal
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