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https://www.readbyqxmd.com/read/28528495/dairy-farm-demographics-and-management-factors-that-played-a-role-in-the-re-emergence-of-brucellosis-on-dairy-cattle-farms-in-fiji
#1
Andrew Tukana, B Gummow
Little is published on risk factors associated with bovine brucellosis in Pacific island communities. The 2009 re-emergence of bovine brucellosis in Fiji enabled us to do an interview-based questionnaire survey of 81 farms in the Wainivesi locality of the Tailevu province on the main island of Fiji to investigate what risk factors could have played a role in the re-emergence of the disease. The survey was conducted on 68 farms that had no positive cases of bovine brucellosis and on 13 farms in the same area where cattle had returned a positive result to the Brucella Rose Bengal test...
May 20, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28518039/central-nervous-system-brucellosis-granuloma-and-white-matter-disease-in-immunocompromised-patient
#2
Mohammed Alqwaifly, Fahad S Al-Ajlan, Hindi Al-Hindi, Abdulaziz Al Semari
Brucellosis is a multisystem zoonotic disease. We report an unusual case of neurobrucellosis with seizures in an immunocompromised patient in Saudi Arabia who underwent renal transplantation. Magnetic resonance imaging of the brain showed diffuse white matter lesions. Serum and cerebrospinal fluid were positive for Brucella sp. Granuloma was detected in a brain biopsy specimen.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28511340/review-of-brucellosis-in-nepal
#3
Krishna Prasad Acharya, Nirajan Niroula, Krishna Kaphle
No abstract text is available yet for this article.
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28508154/estimating-loss-of-brucella-abortus-antibodies-from-age-specific-serological-data-in-elk
#4
J A Benavides, D Caillaud, B M Scurlock, E J Maichak, W H Edwards, P C Cross
Serological data are one of the primary sources of information for disease monitoring in wildlife. However, the duration of the seropositive status of exposed individuals is almost always unknown for many free-ranging host species. Directly estimating rates of antibody loss typically requires difficult longitudinal sampling of individuals following seroconversion. Instead, we propose a Bayesian statistical approach linking age and serological data to a mechanistic epidemiological model to infer brucellosis infection, the probability of antibody loss, and recovery rates of elk (Cervus canadensis) in the Greater Yellowstone Ecosystem...
May 15, 2017: EcoHealth
https://www.readbyqxmd.com/read/28506316/characterization-of-novel-omp31-antigenic-epitopes-of-brucella-melitensis-by-monoclonal-antibodies
#5
Jinfeng Li, Feihuan Hu, Shouyi Chen, Peifang Luo, Zuoping He, Wenjing Wang, Jean-Pierre Allain, Chengyao Li
BACKGROUND: Brucellosis is a severe zoonotic disease worldwide. Detection and identification of Brucella species are essential to prevent or treat brucellosis in humans and animals. The outer membrane protein-31 (Omp31) is a major protein of Brucellae except for B. abortus, while the Omp31 antigenic epitopes have not been extensively characterized yet. RESULTS: A total of 22 monoclonal antibodies (mAbs) were produced against Omp31 of Brucella (B.) melitensis, of which 13 recognized five linear epitopes, 7 reacted with semi-conformational epitopes and 2 reacted with conformational epitopes, respectively...
May 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28503282/skeletal-complications-of-brucellosis-a-study-of-464-cases-in-babol-iran
#6
Soheil Ebrahimpour, Masomeh Bayani, Zahra Moulana, Mohammad Reza Hasanjani Roushan
BACKGROUND: Skeletal complication of brucellosis is common in endemic region of brucellosis, but its frequency has not been clearly determined. The aim of this study was to determine the frequency of skeletal complication in brucellosis patients in Babol, north of Iran. METHODS: From 2005-2015, 1252 cases of brucellosis were diagnosed at the Department of Infectious Diseases, Ayatollah Rouhani Teaching Hospital, in Babol, North of Iran. The diagnosis of brucellosis was established using serum agglutination test (SAT≥1/160), and 2-mercaptoethanol (2ME≥ 1/80) with clinical and epidemiological findings compatible with brucellosis...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28502643/are-brucellosis-q-fever-and-melioidosis-potential-causes-of-febrile-illness-in-madagascar
#7
Ides Boone, Klaus Henning, Angela Hilbert, Heinrich Neubauer, Vera von Kalckreuth, Denise Myriam Dekker, Norbert Georg Schwarz, Gi Deok Pak, Andreas Krüger, Ralf Matthias Hagen, Hagen Frickmann, Jean Noël Heriniaina, Raphael Rakotozandrindrainy, Jean Philibert Rakotondrainiarivelo, Tsiry Razafindrabe, Benedikt Hogan, Jürgen May, Florian Marks, Sven Poppert, Sascha Al Dahouk
Brucellosis, Q fever and melioidosis are zoonoses, which can lead to pyrexia. These diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insufficient awareness by physicians and public health officers and limited diagnostic capabilities, especially in low-resource countries. Therefore, the presence of Brucella spp., Coxiella burnetii and Burkholderia pseudomallei was investigated in Malagasy patients exhibiting febrile illness. In addition, we analyzed zebu cattle and their ticks as potential reservoirs for Brucella and C...
May 11, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28494705/brucellosis-in-endangered-hector-s-dolphins-cephalorhynchus-hectori
#8
K Buckle, W D Roe, L Howe, S Michael, P J Duignan, E Burrows, H Ha, S Humphrey, W L McDonald
Brucella spp infections of marine mammals are often asymptomatic but have been associated with reproductive losses and deaths. Zoonotic infections originating from marine isolates have also been described. Hector's dolphins (Cephalorhynchus hectori) are an endangered species with a declining population, and the role of infectious disease in population dynamics is not fully understood. In this study, 27 Hector's dolphins found dead around the New Zealand coastline between November 2006 and October 2010 were evaluated for lesions previously associated with cetacean brucellosis...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28482164/brucella-melitensis-m5-90%C3%A2-bp26-as-a-potential-live-vaccine-that-allows-for-the-distinction-between-natural-infection-and-immunization
#9
Tiansen Li, Zhixia Tong, Meiling Huang, Liyan Tang, Hui Zhang, Chuangfu Chen
Brucella is Gram-negative intracellular bacterial pathogen that infects humans and animals and contributes to great economic losses in developing countries. Presently, live attenuated Brucella vaccines (B. melitensis strain M5-90) are the most effective means of brucellosis control and prevention in animals. However, these vaccines have several drawbacks, such as an inability to distinguish between a natural infection and immunization and an association with abortions in pregnant animals. Therefore, this study constructed a Brucella M5-90△bp26 mutant and evaluated its virulence...
May 8, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28480256/a-case-report-of-pediatric-brucellosis-in-an-algerian-immigrant
#10
Eimear Kitt, Kristina R Brannock, Lauren A VonHolz, Paul J Planet, Erin Graf, Vinodh Pillai
An 8-year old girl presented to our facility with a 10-day history of fever, fatigue, abdominal pain and refusal to walk. She recently travelled from her native Algeria where she first developed symptoms. On evaluation, she was ill-appearing, febrile and tachycardic with hepatosplenomegaly and lymphadenopathy noted on examination. A strong musty odor was also noted from the child. Laboratory evaluation revealed pancytopenia, hyponatremia, and an elevated AST, ALT, and LDH. Malaria testing was negative, as was a PPD...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28479744/high-throughput-virtual-screening-to-identify-novel-natural-product-inhibitors-for-methionyltrna-synthetase-of-brucella-melitensis
#11
Madhulata Kumari, Subhash Chandra, Neeraj Tiwari, Naidu Subbarao
The Brucella melitensis methionyl-tRNA-synthetase (MetRSBm) is a promising target for brucellosis drug development. The virtual screening of large libraries of a drug like molecules against a protein target is a common strategy used to identify novel inhibitors. A High throughput virtual screening was performed to identify hits to the potential antibrucellosis drug target, MetRSBm. The best inhibitor identified from the literature survey was 1312, 1415, and 1430. In the virtual screening 56,400 compounds of ChEMBL antimycobacterial library, 1596 approved drugs, 419 Natural product IV library, and 2396 methionine analogous were docked and rescoring, identified top 10 ranked compounds as anti-mycobacterial leads showing G-scores -10...
2017: Bioinformation
https://www.readbyqxmd.com/read/28473914/isolated-splenic-abscess-in-brucellosis
#12
Sreenivasa Rao Sudulagunta, Monica Kumbhat, Mahesh Babu Sodalagunta, Aravinda Settikere Nataraju, Shiva Kumar Bangalore Raja
Brucellosis is a zoonotic infectious disease, which can attack any organ of the body but mainly involves lymphoreticular system. Our case report describes isolated splenic abscess diagnosed in a 50-year-old individual who is a milk vendor by occupation and has the habit of consuming raw milk. He was admitted with pain abdomen, high-grade fever with chills, generalized malaise, night sweats and weight loss. Ultrasound and computerized tomography of the abdomen showed splenomegaly and hypodense, nonenhancing lesion measuring 3...
February 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28468058/-analysis-on-the-epidemiological-features-of-human-brucellosis-in-northern-and-southern-areas-of-china-2015-2016
#13
Y J Shi, S J Lai, Q L Chen, D Mu, Y Li, X X Li, W W Yin, H J Yu
Objective: To analyze the epidemiological characteristics of human brucellosis in northern and southern areas of China, and to develop national strategies for brucellosis prevention and control. Methods: Individual data on human brucellosis was collected from the National Notifiable Infectious Disease Reporting Information System to describe the situation of brucellosis in China during 2015-2016. Epidemiological features of the disease in northern and southern areas of China were analyzed. Results: A total of 104 125 cases were reported in mainland China during 2015-2016, with an average incidence rate as 3...
April 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28466240/incidence-and-knowledge-of-bovine-brucellosis-in-kahuro-district-murang-a-county-kenya
#14
Janeffer N Njuguna, Michael M Gicheru, Lucy M Kamau, Peter M Mbatha
Brucellosis in cattle is a zoonosis mainly caused by Brucella abortus. In Kenya, the disease is widespread, but its prevalence is largely unknown. The objective of this study was to investigate incidence rates of brucellosis and farmers' knowledge on the disease in Kahuro district, Murang'a County. In this study, 150 pooled milk samples were collected from 75 milk collection centers and tested. Subsequently, 230 milk samples were collected from farmers in 16 collection centers in Wangu and Mugoiri divisions whose pooled samples gave positive results...
May 3, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28460642/multi-locus-variable-number-tandem-repeat-analysis-of-chinese-brucella-strains-isolated-from-1953-to-2013
#15
Guo-Zhong Tian, Bu-Yun Cui, Dong-Ri Piao, Hong-Yan Zhao, Lan-Yu Li, Xi Liu, Pei Xiao, Zhong-Zhi Zhao, Li-Qing Xu, Hai Jiang, Zhen-Jun Li
BACKGROUND: Brucellosis was a common human and livestock disease caused by Brucella strains, the category B priority pathogens by the US Center for Disease Control (CDC). Identified as a priority disease in human and livestock populations, the increasing incidence in recent years in China needs urgent control measures for this disease but the molecular background important for monitoring the epidemiology of Brucella strains at the national level is still lacking. METHODS: A total of 600 Brucella isolates collected during 60 years (from 1953 to 2013) in China were genotyped by multiple locus variable-number tandem repeat analysis (MLVA) and the variation degree of MLVA11 loci was calculated by the Hunter Gaston Diversity Index (HGDI) values...
May 2, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28459811/the-clinical-features-of-590-patients-with-brucellosis-in-xinjiang-china-with-the-emphasis-on-the-treatment-of-complications
#16
Bin Jia, Fengbo Zhang, Ying Lu, Wenbao Zhang, Jun Li, Yuexin Zhang, Jianbing Ding
BACKGROUND: This study aims to analyze the clinical characteristics and treatment outcomes of 590 patients with brucellosis in Xinjiang, China. METHODOLOGY AND PRINCIPAL FINDINGS: The clinical characteristics, laboratory findings, complications and prognosis of 590 patients infected with brucellosis were retrospectively analyzed. These patients had a mean age of 44.24 ± 15.83 years with 60.5% having a history of close contacting with cattle and sheep. Of them, 53...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28456876/seroprevalence-of-brucella-antibodies-in-camels-in-katsina-state-nigeria
#17
U S Salisu, C A Kudi, J O O Bale, M Babashani, B Y Kaltungo, S N A Saidu, A Asambe, A Y Baba
A cross-sectional study was carried out to determine the status of Brucella infection in one-humped (Dromedary) camels in the North and Central senatorial districts of Katsina State, Nigeria. Nine hundred and eighty serum samples from live and slaughtered camels were tested. Modified Rose Bengal plate test (RBPT) and serum agglutination test (SAT) with ethylenediaminetetraacetic acid, (EDTA) were used as screening and standard tests, respectively. The prevalence of Brucella antibodies were 110 (11.2%) and 103 (10...
April 29, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28443226/a-novel-pcr-assay-for-detecting-brucella-abortus-and-brucella-melitensis
#18
Saeed Alamian, Majid Esmaelizad, Taghi Zahraei, Afshar Etemadi, Mohsen Mohammadi, Davoud Afshar, Soheila Ghaderi
OBJECTIVES: Brucellosis is a major zoonotic disease that poses a significant public health threat worldwide. The classical bacteriological detection process used to identify Brucella spp. is difficult and time-consuming. This study aimed to develop a novel molecular assay for detecting brucellosis. METHODS: All complete sequences of chromosome 1 with 2.1-Mbp lengths were compared among all available Brucella sequences. A unique repeat sequence (URS) locus on chromosome 1 could differentiate Brucella abortus from Brucella melitensis...
February 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28432940/a-sandwich-immunoassay-for-brucellosis-diagnosis-based-on-immune-magnetic-beads-and-quantum-dots
#19
Li Li, Dehui Yin, Kun Xu, Yushen Liu, Dandan Song, Juan Wang, Chao Zhao, Xiuling Song, Juan Li
Brucellosis is a serious zoonosis with a rapid increase in incidence across epidemic regions. Currently, there are numerous methods for diagnosing brucellosis. However, these studies often have a few defects, such as low sensitivity, poor specificity, time consuming, laborious, and even potential biological risk. To overcome these shortcomings, we have developed a rapid, sensitive and accurate diagnosis procedure for brucellosis based on the immune magnetic beads (IMB) probe and quantum dots (QDs) - staphylococcal protein A (SPA) probe...
April 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28411163/development-of-a-multi-epitope-peptide-vaccine-inducing-robust-t-cell-responses-against-brucellosis-using-immunoinformatics-based-approaches
#20
Mahdiye Saadi, Ahmad Karkhah, Hamid Reza Nouri
Current investigations have demonstrated that a multi-epitope peptide vaccine targeting multiple antigens could be considered as an ideal approach for prevention and treatment of brucellosis. According to the latest findings, the most effective immunogenic antigens of brucella to induce immune responses are included Omp31, BP26, BLS, DnaK and L7-L12. Therefore, in the present study, an in silico approach was used to design a novel multi-epitope vaccine to elicit a desirable immune response against brucellosis...
April 11, 2017: Infection, Genetics and Evolution
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