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https://www.readbyqxmd.com/read/28196298/human-to-human-transmission-of-brucella-a-systematic-review
#1
REVIEW
Felipe F Tuon, Regina B Gondolfo, Natacha Cerchiari
OBJECTIVE: The most common form of transmitting human brucellosis is through contaminated food or direct contact with infected animals. Human-to-human transmission (HHT) has been described as isolated case reports. The aim of this systematic review was to describe all cases of HHT of human brucellosis reported in the medical literature. METHODS: A literature search was conducted using PubMed, Scopus and Scielo databases using specific search terms published until March 2016...
February 14, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28183751/genome-sequences-of-human-and-livestock-isolates-of-brucella-melitensis-and-brucella-abortus-from-the-country-of-georgia
#2
Ketevan Sidamonidze, Jun Hang, Yu Yang, George Dzavashvili, Ekaterine Zhgenti, Nino Trapaidze, Paata Imnadze, Mikeljon P Nikolich
Brucellosis, which is among the most widespread global zoonotic diseases, is endemic in the nation of Georgia and causes substantial human morbidity and economic loss. Here, we report whole-genome sequences of three Brucella melitensis and seven Brucella abortus isolates from cattle, sheep, and humans that represent genetic groups discovered in Georgia.
February 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28176187/brucellosis-and-associated-risk-factors-in-dairy-cattle-of-eastern-ethiopia
#3
Yitagele Terefe, Sisay Girma, Negesse Mekonnen, Biruhtesfa Asrade
Knowing the status of Bovine brucellosis and associated risk factors is a crucial step in formulating evidence based control scheme. In this study, a total of 967 dairy cows from 307 dairy farms in eastern Ethiopia were serologically tested for Brucella antibodies. The screening was done first using RBPT and positive samples were subsequently subjected to CFT for confirmation. A pre-tested structured questionnaire was used to collect relevant data from 307 dairy cattle owners or attendants to assess their awareness and routine practice...
February 7, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28167945/tlr7-and-tlr3-sense-brucella-abortus-rna-to-induce-proinflammatory-cytokine-production-but-they-are-dispensable-for-host-control-of-infection
#4
Priscila C Campos, Marco Túlio R Gomes, Erika S Guimarães, Gabriela Guimarães, Sergio C Oliveira
Brucella abortus is a Gram-negative, facultative intracellular bacterium that causes brucellosis, a worldwide zoonotic disease leading to undulant fever in humans and abortion in cattle. The immune response against this bacterium relies on the recognition of microbial pathogen-associated molecular patterns, such as lipoproteins, lipopolysaccharides, and DNA; however, the immunostimulatory potential of B. abortus RNA remains to be elucidated. Here, we show that dendritic cells (DCs) produce significant amounts of IL-12, IL-6, and IP-10/CXCL10, when stimulated with purified B...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28166930/polymeric-antigen-blsomp31-in-aluminium-hydroxide-induces-serum-bactericidal-and-opsonic-antibodies-against-brucella-canis-in-dogs
#5
Maria Clausse, Alejandra G Díaz, Romina P Pardo, Vanesa Zylberman, Fernando A Goldbaum, Silvia M Estein
Polymeric antigen BLSOmp31 is an immunogenic vaccine candidate that confers protection against Brucella canis in mice. In this preliminary study, the immunogenicity and safety of BLSOmp31 adsorbed to aluminum hydroxide gel (BLSOmp31-AH) were evaluated in Beagle dogs. In addition, the potential to elicit serum antibodies with complement-dependent bactericidal activity and/or to enhance phagocytosis by neutrophils were analyzed. Dogs were immunized three times with BLSOmp31-AH by subcutaneous route, followed by an annual booster...
February 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28164606/increased-plasma-levels-of-heme-oxygenase-1-in-human-brucellosis
#6
Zhe Chen, Yu-Xue Zhang, Dong-Wei Fu, Qing-Feng Gao, Feng-Xia Ge, Wei-Hua Liu
BACKGROUND: Brucellosis is associated with inflammation and the oxidative stress response. Heme oxygenase-1 (HO-1) is a cytoprotective stress-responsive enzyme that has anti-inflammatory and anti-oxidant effects. Nevertheless, the role of HO-1 in human brucellosis has not yet been studied. The aim of this study was to examine the plasma levels of HO-1 in patients with brucellosis and to evaluate the ability of plasma HO-1 levels as an auxiliary diagnosis, a severity predictor, and a monitor for brucellosis treatments...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164569/comparison-of-a-novel-test-odak-brucella-coombs-gel-test-with-commonly-used-serological-tests-in-human-brucellosis
#7
Baris Ata Borsa, Mehmet Ersoy Aldag, Meric Yilmaz, Zeynep Gungordu Dalar, Veli Cengiz Ozalp
BACKGROUND: Since Brucellosis is difficult to diagnose based on clinical symptoms, the diagnosis mostly relies on the results of serological testing. ODAK Brucella Coombs Gel Test is a novel and rapid gel microcolumn agglutination test which is performed in microcolumns containing gel matrix and Coombs antibodies. In this study, we aimed to compare ODAK Brucella Coombs Gel Test with other commonly used serological tests. METHODS: 150 blood samples of patients, preliminarily diagnosed as Brucellosis, were included in this study...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162961/undifferentiated-tropical-febrile-illness-in-cordoba-colombia-not-everything-is-dengue
#8
Salim Mattar, Vaneza Tique, Jorge Miranda, Eney Montes, Denisses Garzon
In Colombia, undifferentiated tropical febrile illness (UTFI) are frequent and of considerable concern. They also share many clinical features. Between 2012 and 2013 in an endemic tropical area of Cordoba, Colombia, we conducted a prospective study to establish an etiological diagnosis of UTFI. Using diagnostic tests for dengue, leptospirosis, hantavirus, malaria, rickettsia, brucellosis, hepatitis A and B on 100 patients recruited for the study. We identified 69 patients with presumed UTFI: leptospirosis (n=27), dengue (n=26), hantavirus infection (n=4), malaria (n=4), rickettsial infection (n=2), hepatitis A (n=1), and brucellosis (n=1); no hepatitis B cases were detected...
February 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28162129/assessment-of-community-awareness-and-risk-perceptions-of-zoonotic-causes-of-abortion-in-cattle-at-three-selected-livestock-wildlife-interface-areas-of-zimbabwe
#9
M Ndengu, M DE Garine-Wichatitsky, D M Pfukenyi, M Tivapasi, B Mukamuri, G Matope
A study was conducted to assess the awareness of cattle abortions due to brucellosis, Rift Valley fever (RVF) and leptospirosis, and to compare frequencies of reported abortions in communities living at the periphery of the Great Limpopo Transfrontier Conservation Area in southeastern Zimbabwe. Three study sites were selected based on the type of livestock-wildlife interface: porous livestock-wildlife interface (unrestricted); non-porous livestock-wildlife interface (restricted by fencing); and livestock-wildlife non-interface (totally absent or control)...
February 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28160160/the-unexpected-discovery-of-brucella-abortus-buck-19-vaccine-in-goats-from-ecuador-underlines-the-importance-of-biosecurity-measures
#10
Jorge Ron-Román, Dirk Berkvens, Daniela Barzallo-Rivadeneira, Alexandra Angulo-Cruz, Pablo González-Andrade, Elizabeth Minda-Aluisa, Washington Benítez-Ortíz, Jef Brandt, Richar Rodríguez-Hidalgo, Claude Saegerman
Very few, mostly old, and only preliminary serological studies of brucellosis in goats exist in Ecuador. In order to assess the current epidemiological situation, we performed a cross-sectional serological study in the goat populations of Carchi (n = 160 animals), Pichincha (n = 224 animals), and Loja provinces (n = 2024 animals). Only two positive serological results (RB negative and SAT-EDTA ≥400 IU/ml) were obtained in lactating goats from the same farm in Quito (Pichincha province). Additionally, milk was sampled from 220 animals in Pichincha province...
February 3, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28152976/origins-and-global-context-of-brucella-abortus-in-italy
#11
Giuliano Garofolo, Elisabetta Di Giannatale, Ilenia Platone, Katiuscia Zilli, Lorena Sacchini, Anna Abass, Massimo Ancora, Cesare Cammà, Guido Di Donato, Fabrizio De Massis, Paolo Calistri, Kevin P Drees, Jeffrey T Foster
BACKGROUND: Brucellosis is a common and chronic disease of cattle and other bovids that often causes reproductive disorders. Natural infection in cattle is caused by Brucella abortus and transmission typically occurs during abortions, calving, or nursing. Brucellosis is also a major zoonotic disease due to contamination of dairy products or contact with the tissues of infected animals. Brucellosis has been eradicated from most of the developed world in the last 40 years but persists in many regions-the disease remains prevalent in portions of Africa, the Middle East, Asia, and Central and South America, as well as in the Mediterranean basin...
February 2, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28149665/seronegative-brucellosis-of-the-spine-a-case-of-psoas-abscess-secondary-to-brucellar-spondylitis
#12
Gülnur Taşcı Bozbaş, Ayşe İyiyapıcı Ünübol, Gülcan Gürer
Brucellosis is an infectious disease that affects many organ systems. Osteoarticular involvement, especially spondylitis, is the most common complication of brucellosis, but psoas abscess is very rare. Serological tests at diagnosis of the disease are very valuable and most widely used. Herein, we report a case of psoas abscess secondary to brucellar spondylitis. In this case, interestingly, the serological test results were negative, and the diagnosis could be made by abscess culture. In patients, particularly those who live in areas endemic for brucellosis, as in our case, it should be kept in mind that a negative serological test result should not exclude the diagnosis of brucellosis...
December 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28149294/mlva-genotyping-characteristics-of-human-brucella-melitensis-isolated-from-ulanqab-of-inner-mongolia-china
#13
Zhi-Guo Liu, Dong-Dong Di, Miao Wang, Ri-Hong Liu, Hong-Yan Zhao, Dong-Ri Piao, Guo-Zhong Tian, Wei-Xing Fan, Hai Jiang, Bu-Yun Cui, Xian-Zhu Xia
Brucellosis is a serious public health problem in Ulanqab, which is a region located in the middle of the Inner Mongolia Autonomous Region adjacent to Shanxi and Hebei provinces. The disease is prevalent in both the latter provinces and Ulanqab with the highest prevalence of brucellosis occurring in Inner Mongolia. The MLVA-16 scheme is a genotyping tool for assessing genetic diversity and relationships among isolates. Moreover, this genotyping tool can also be applied to epidemiological trace-back investigations...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28146190/-brucellosis-a-zoonosis-of-importance-in-mexico
#14
Rosa Lilia Guzmán-Hernández, Araceli Contreras-Rodríguez, Eric Daniel Ávila-Calderón, M Rosario Morales-García
INTRODUCTION: Brucellosis is one of the most frequent zoonosis in most parts of the world. This zoonosis remains a great problem to public health in developing countries, although developed countries have successfully controlled it. Mexico still shows a high annual brucellosis incidence in humans; thus, the country is considered around the world as an endemic brucellosis country. AIM: To describe the connection/association between this zoonosis and the current epidemiological situation in the Mexican population...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28144188/clinical-manifestations-in-82-neurobrucellosis-patients-from-kosovo
#15
Shemsedin Dreshaj, Nexhmedin Shala, Gresa Dreshaj, Naser Ramadani, Albina Ponosheci
BACKGROUND: Central nervous system involvement is a serious complication of brucellosis with various incidence and various clinical presentations. PATIENTS AND METHODS: Hospitalized patients in University Clinical Centre, Clinic for Infectious diseases in Prishtina, with laboratory-confirmed brucellosis, were analyzed, a brucellosis-endemic region. Among the 648 confirmed cases with brucellosis during the period 1991- 2013, 82 patients (12.65%) were diagnosed with neurobrucellosis...
December 2016: Materia Socio-medica
https://www.readbyqxmd.com/read/28143800/right-ventricular-outflow-tract-endocarditis-caused-by-brucellosis
#16
Feridoun Sabzi, Aghighe Heidari, Reza Faraji
Right-ventricular outflow tract (RVOT) endocarditis is a very rare presentation of right-sided infective endocarditis (RSIE) by brucellosis. RSIE occurs most commonly in immune-suppressed cases and illicit drug abuser. The patients with RSIE and an incompetent immune system usually have a prosthetic foreign body in blood circulation such as catheter, pacemakers, or central venous lines and may be accompanied with tricuspid or pulmonary valve dysfunction. The most common site for RSIE is the tricuspid valve...
January 29, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28131952/brucella-abortus-2308%C3%AE-nodv%C3%AE-nodw-double-mutant-is-highly-attenuated-and-confers-protection-against-wild-type-challenge-in-balb-c-mice
#17
Zhiqiang Li, Shuli Wang, Jinliang Zhang, Guangli Yang, Baodong Yuan, Jie Huang, Jincheng Han, Li Xi, Yanren Xiao, Chuangfu Chen, Hui Zhang
Brucellosis is an important zoonotic disease of worldwide distribution, which causes animal and human disease. However, the current Brucella abortus (B. abortus) vaccines (S19 and RB51) have several drawbacks, including residual virulence for animals and humans. Moreover, S19 cannot allow serological differentiation between infected and vaccinated animals. We constructed double deletion (ΔNodVΔNodW) mutant from virulent B. abortus 2308 (S2308) by deleting the genes encoding two-component regulatory system (TCS) in chromosome II in S2308...
January 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28131373/molecular-epidemiological-investigation-of-brucella-melitensis-circulating-in-mongolia-by-mlva16
#18
Sung-Il Kang, Moon Her, Janchivdorj Erdenebaataar, Batbaatar Vanaabaatar, Hyorim Cho, So-Ra Sung, Jin Ju Lee, Suk Chan Jung, Yong Ho Park, Ji-Yeon Kim
Mongolia has a high incidence of brucellosis in human and animals due to livestock husbandry. To investigate the genetic characteristics of Mongolian B. melitensis, an MLVA (multi-locus variable-number tandem-repeat analysis)-16 assay was performed with 94 B. melitensis isolates. They were identified as B. melitensis biovar (bv.) 1 (67), 3 (10) and Rev. 1 vaccine strains (17) using a classical biotyping and multiplex PCR. In genotyping, three human isolates were grouped at 2 genotypes with sheep isolates, and it implies that B...
February 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28129882/plantar-fasciitis-and-bone-marrow-edema-in-brucellosis
#19
Yilmaz Seçilmiş, Feyza Hüsrevoğlu, Derda Yucel, Mehmet Adnan Öztürk
No abstract text is available yet for this article.
January 24, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28129787/seroprevalence-and-risk-factors-associated-with-bovine-brucellosis-in-the-potohar-plateau-pakistan
#20
Shahzad Ali, Shamim Akhter, Heinrich Neubauer, Falk Melzer, Iahtasham Khan, Emmanuel Nji Abatih, Hosny El-Adawy, Muhammad Irfan, Ali Muhammad, Muhammad Waqas Akbar, Sajid Umar, Qurban Ali, Muhammad Naeem Iqbal, Abid Mahmood, Haroon Ahmed
BACKGROUND: The seroprevalence and risk factors of bovine brucellosis were studied at animal and herd level using a combination of culture, serological and molecular methods. The study was conducted in 253 randomly selected cattle herds of the Potohar plateau, Pakistan from which a total of 2709 serum (1462 cattle and 1247 buffaloes) and 2330 milk (1168 cattle and 1162 buffaloes) samples were collected. Data on risk factors associated with seroprevalence of brucellosis were collected through interviews using questionnaires...
January 28, 2017: BMC Research Notes
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