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Cochlear implants

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https://www.readbyqxmd.com/read/27933352/intracochlear-drug-delivery-in%C3%A2-combination-with-cochlear-implants-current-aspects
#1
S K Plontke, G Götze, T Rahne, A Liebau
Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (i. e., through intratympanic injection), intracochlear administration (particularly for gene and stem cell therapy), as well as various combinations with auditory neurosensory prostheses, either evaluated in preclinical or clinical studies, or off-label. To improve rehabilitation with cochlear implants (CI), one focus is the development of drug-releasing electrode carriers, e...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933290/validation-of-a-cochlear-implant-patient-specific-model-of-the-voltage-distribution-in-a-clinical-setting
#2
Waldo Nogueira, Daniel Schurzig, Andreas Büchner, Richard T Penninger, Waldemar Würfel
Cochlear Implants (CIs) are medical implantable devices that can restore the sense of hearing in people with profound hearing loss. Clinical trials assessing speech intelligibility in CI users have found large intersubject variability. One possibility to explain the variability is the individual differences in the interface created between electrodes of the CI and the auditory nerve. In order to understand the variability, models of the voltage distribution of the electrically stimulated cochlea may be useful...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27930861/functional-mri-in-seven-borderline-cochlear-implant-candidates-a-preliminary-research-study
#3
F Wagner, S Weder, M D Caversaccio, A Federspiel, R Wiest, P Senn
The indications for cochlear implants (CIs) are constantly expanding, as are the numbers of patients who are not ideal or classical CI candidates. For these patients, a careful decision-making process is needed to minimize the risk of poor outcomes. Preoperatively, it may be unclear whether they will benefit from an implantation. As conventionally performed hearing tests (i.e. subjective and electrophysiological examinations, stapedial reflex testing) have limitations, further objective and effective methods for assessment of the central auditory pathway (CAP) are required [1-3]...
December 8, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27927962/selective-neuronal-activation-by-cochlear-implant-stimulation-in-auditory-cortex-of-awake-primate
#4
Luke A Johnson, Charles C Della Santina, Xiaoqin Wang
: Despite the success of cochlear implants (CIs) in human populations, most users perform poorly in noisy environments and music and tonal language perception. How CI devices engage the brain at the single neuron level has remained largely unknown, in particular in the primate brain. By comparing neuronal responses with acoustic and CI stimulation in marmoset monkeys unilaterally implanted with a CI electrode array, we discovered that CI stimulation was surprisingly ineffective at activating many neurons in auditory cortex, particularly in the hemisphere ipsilateral to the CI...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27925583/modeling-electrode-place-discrimination-in-cochlear-implant-stimulation
#5
Xiao Gao, David Bruce Grayden, Mark D McDonnell
OBJECTIVE: By modeling the cochlear implant (CI) electrode-to-nerve interface and quantifying electrode discriminability in the model, we address the questions of how many individual channels can be distinguished by CI recipients and the extent to which performance might be improved by inserting electrodes deeper into the cochlea. METHOD: We adapt an artificial neural network to model electrode discrimination, as well as a commonly used psychophysical measure (four-interval forcedchoice) in CI stimulation and predict how well the locations of the stimulating electrodes can be inferred from simulated auditory nerve spiking patterns...
December 1, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27921115/-speech-audiometry-for-indication-of-conventional-and-implantable-hearing-aids
#6
U Hoppe, A Hast
The social function of the human hearing apparatus is comprehension of speech. Auditory rehabilitation aims to enhance speech perception in everyday life. Consequently, audiological evaluation contains speech perception measurement. Many speech audiometric methods have been developed in German-speaking countries, which are suitable for quantification of speech perception abilities in quiet and in noise to address specific diagnostic questions. For establishment of the indication for technical hearing systems such as hearing aids and cochlear implants, the Freiburg monosyllabic test has been employed successfully for many years...
December 5, 2016: HNO
https://www.readbyqxmd.com/read/27921114/-postoperative-imaging-of-the-internal-auditory-canal-visualization-of-active-auditory-implants-german-version
#7
I Todt, G Rademacher, P Mittmann, S Mutze, A Ernst
BACKGROUND: Assessment of the internal auditory canal (IAC) and the cochlea is of central importance in neurotology. The artefacts and visibility of the different types of active auditory implants in MRI vary, due to their specific ferromagnetic components. Knowledge of the size of MRI artefacts and the options for handling these is important for the auditory rehabilitation of specific diseases (e. g., vestibular schwannoma). METHODS: The current paper is a literature review RESULTS: MRI assessment of the IAC and cochlea after surgical placement of an active auditory implant is feasible only with a percutaneous bone-anchored hearing aid (BAHA, Ponto)...
December 5, 2016: HNO
https://www.readbyqxmd.com/read/27918368/what-can-long-term-attendance-at-programming-appointments-tell-us-about-pediatric-cochlear-implant-recipients
#8
Dawn Choo, Shani Joy Dettman
OBJECTIVE: This study sought to understand factors linked to long-term engagement with available post-implant "mapping" review services for individuals who received cochlear implants (CI)(s) as children. STUDY DESIGN: Demographics, communication outcomes, and appointment attendance records from an unselected group of 400 participants who received CI(s) between 1985 and 2009 were analyzed. RESULTS: After 5 years post-implant, 85.75% (n = 343) of participants attended the clinic for "mapping" appointments between March 2011 and March 2014, but 14...
December 1, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27918363/tip-fold-over-in-cochlear-implantation-case-series
#9
M Geraldine Zuniga, Alejandro Rivas, Andrea Hedley-Williams, Rene H Gifford, Robert Dwyer, Benoit M Dawant, Linsey W Sunderhaus, Kristen L Hovis, George B Wanna, Jack H Noble, Robert F Labadie
OBJECTIVE: To describe the incidence, clinical presentation, and performance of cochlear implant (CI) recipients with tip fold-over. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: CI recipients who underwent postoperative computed tomography (CT) scanning. INTERVENTION(S): Tip fold-over was identified tomographically using previously validated software that identifies the electrode array...
December 1, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27918225/clinical-surgical-and-electrical-factors-impacting-residual-hearing-in-cochlear-implant-surgery
#10
Adrien A Eshraghi, Jamal Ahmed, Eric Krysiak, Kadri Ila, Peter Ashman, Fred F Telischi, Simon Angeli, Sandra Prentiss, Diane Martinez, Sandra Valendia
CONCLUSIONS: This study recommends using soft surgical principal and round window insertion to protect residual hearing with favorable anatomical exposure. Further studies are needed to evaluate the impact of the electrical stimulation on the organ of corti and hearing. OBJECTIVE: The objective of this study is to analyze various factors that impact on preservation of residual hearing post-implantation. METHODS: A retrospective study was performed to analyze loss of residual hearing in a cohort of 225 patients implanted in a large academic center...
December 5, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27916008/facial-nerve-anomalies-in-paediatric-cochlear-implant-candidates-radiological-evaluation
#11
F B Palabiyik, K Hacikurt, Z Yazici
BACKGROUND: Pre-operative radiological identification of facial nerve anomalies can help prevent intra-operative facial nerve injury during cochlear implantation. This study aimed to evaluate the incidence and configuration of facial nerve anomalies and their concurrence with inner-ear anomalies in cochlear implant candidates. METHODS: Inner-ear and concomitant facial nerve anomalies were evaluated by magnetic resonance imaging and temporal high-resolution computed tomography in 48 children with congenital sensorineural hearing loss who were cochlear implant candidates...
December 5, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27916007/characteristics-and-clinical-use-of-ocular-and-cervical-vestibular-evoked-myogenic-potentials-for-evaluating-paediatric-candidates-for-cochlear-implants
#12
X-D Xu, J Hu, Q Zhang, Y Zhang, X-T Zhang, Y-F Chen, M Xu
OBJECTIVE: This study aimed to define the characteristics and use of ocular and cervical vestibular evoked myogenic potentials for evaluating paediatric cochlear implant candidates. METHODS: Ocular and cervical vestibular evoked myogenic potentials of 34 paediatric cochlear implant candidates were analysed. All patients also underwent a routine audiological examination, including computed tomography. RESULTS: In all, 27 patients with normal inner-ear structures had absent or impaired vestibular evoked myogenic potential responses...
December 5, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27914426/amplitude-modulation-detection-with-concurrent-frequency-modulation
#13
Naveen K Nagaraj
Human speech consists of concomitant temporal modulations in amplitude and frequency that are crucial for speech perception. In this study, amplitude modulation (AM) detection thresholds were measured for 550 and 5000 Hz carriers with and without concurrent frequency modulation (FM), at AM rates crucial for speech perception. Results indicate that adding 40 Hz FM interferes with AM detection, more so for 5000 Hz carrier and for frequency deviations exceeding the critical bandwidth of the carrier frequency...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914414/spatial-attention-in-bilateral-cochlear-implant-users
#14
Matthew J Goupell, Alan Kan, Ruth Y Litovsky
Cochlear-implant (CI) users have difficulty understanding speech in the presence of interfering sounds. This study was designed to determine if binaural unmasking of speech is limited by peripheral or central encoding. Speech was presented to bilateral CI listeners using their clinical processors; unprocessed or vocoded speech was presented to normal-hearing (NH) listeners. Performance was worst for all listener groups in conditions where both the target and interferer were presented monaurally or diotically (i...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27914377/evaluating-multipulse-integration-as-a-neural-health-correlate-in-human-cochlear-implant-users-relationship-to-spatial-selectivity
#15
Ning Zhou, Bryan E Pfingst
The decrease of psychophysical detection thresholds as a function of pulse rate for a fixed-duration electrical pulse train is referred to as multipulse integration (MPI). The MPI slopes correlate with anatomical and physiological indices of cochlear health in guinea pigs with cochlear implants. The aim of the current study was to assess whether the MPI slopes were related to the spatial spread of activation by electrical stimulation. The hypothesis was that MPI is dependent on the total number of excitable neurons at the stimulation site, with broader neural excitation producing a steeper threshold decrease as a function of stimulation rate...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27913315/speech-enhancement-based-on-neural-networks-improves-speech-intelligibility-in-noise-for-cochlear-implant-users
#16
Tobias Goehring, Federico Bolner, Jessica J M Monaghan, Bas van Dijk, Andrzej Zarowski, Stefan Bleeck
Speech understanding in noisy environments is still one of the major challenges for cochlear implant (CI) users in everyday life. We evaluated a speech enhancement algorithm based on neural networks (NNSE) for improving speech intelligibility in noise for CI users. The algorithm decomposes the noisy speech signal into time-frequency units, extracts a set of auditory-inspired features and feeds them to the neural network to produce an estimation of which frequency channels contain more perceptually important information (higher signal-to-noise ratio, SNR)...
November 29, 2016: Hearing Research
https://www.readbyqxmd.com/read/27909890/does-severity-of-cerebral-mri-lesions-in-congenital-cmv-infection-correlates-with-the-outcome-of-cochlear-implantation
#17
Stefan Lyutenski, Friedrich Götz, Alexandros Giourgas, Omid Majdani, Eva Bültmann, Heinrich Lanfermann, Thomas Lenarz, Anja M Giesemann
The objective is to investigate whether there is a correlation between the severity of typical brain lesions in congenital cytomegalovirus (cCMV) infection and cochlear implant (CI) outcome. The design of the study is a retrospective single-institutional chart review (2005-2015), performed in a tertiary academic referral center. 23 children with typical signs of cCMV infection on cerebral magnetic resonance imaging (MRI) and bilateral severe-to-profound sensorineural hearing loss were retrospectively evaluated...
December 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27909888/off-the-ear-with-no-loss-in-speech-understanding-comparing-the-rondo-and-the-opus-2-cochlear-implant-audio-processors
#18
Stefan Dazert, Jan Peter Thomas, Andreas Büchner, Joachim Müller, John Martin Hempel, Hubert Löwenheim, Robert Mlynski
The RONDO is a single-unit cochlear implant audio processor, which omits the need for a behind-the-ear (BTE) audio processor. The primary aim was to compare speech perception results in quiet and in noise with the RONDO and the OPUS 2, a BTE audio processor. Secondary aims were to determine subjects' self-assessed levels of sound quality and gather subjective feedback on RONDO use. All speech perception tests were performed with the RONDO and the OPUS 2 behind-the-ear audio processor at 3 test intervals. Subjects were required to use the RONDO between test intervals...
December 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27908067/lateralization-of-interaural-timing-differences-with-multi-electrode-stimulation-in-bilateral-cochlear-implant-users
#19
Alan Kan, Heath G Jones, Ruth Y Litovsky
Bilateral cochlear implant (BiCI) users have shown variability in interaural time difference (ITD) sensitivity at different places along the cochlea. This paper investigates perception of multi-electrode binaural stimulation to determine if auditory object formation (AOF) and lateralization are affected by variability in ITD sensitivity when a complex sound is encoded with multi-channel processing. AOF and ITD lateralization were compared between single- and multi-electrode configurations. Most (7/8) BiCI users perceived a single auditory object with multi-electrode stimulation, and the range of lateralization was comparable to single-electrode stimulation, suggesting that variability in single-electrode ITD sensitivity does not compromise AOF with multi-electrode stimulation...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27908046/band-importance-functions-of-listeners-with-cochlear-implants-using-clinical-maps
#20
Adam K Bosen, Monita Chatterjee
Band importance functions estimate the relative contribution of individual acoustic frequency bands to speech intelligibility. Previous studies of band importance in listeners with cochlear implants have used experimental maps and direct stimulation. Here, band importance was estimated for clinical maps with acoustic stimulation. Listeners with cochlear implants had band importance functions that relied more heavily on lower frequencies and showed less cross-listener consistency than in listeners with normal hearing...
November 2016: Journal of the Acoustical Society of America
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