Qun Wang, Jinxin Wang, Dianping Yu, Qing Zhang, Hongmei Hu, Mengting Xu, Hongwei Zhang, Saisai Tian, Guangyong Zheng, Dong Lu, Jiajia Hu, Mengmeng Guo, Minchen Cai, Xiangxin Geng, Yanyan Zhang, Jianhua Xia, Xing Zhang, Ang Li, Sanhong Liu, Weidong Zhang
Programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) blockade has become a mainstay of cancer immunotherapy. Targeting the PD-1/PD-L1 axis with small molecules is an attractive approach to enhance antitumor immunity. Here, we identified a natural marine product, benzosceptrin C (BC), that enhances the cytotoxicity of T cells to cancer cells by reducing the abundance of PD-L1. Furthermore, BC exerts its antitumor effect in mice bearing MC38 tumors by activating tumor-infiltrating T cell immunity...
January 11, 2024: Cell reports medicine