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Recycling endosome

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https://www.readbyqxmd.com/read/29676464/the-endosomal-recycling-of-fgsnc1-by-fgsnx41-fgsnx4-heterodimer-is-essential-for-polarized-growth-and-pathogenicity-in-fusarium-graminearum
#1
Wenhui Zheng, Yahong Lin, Wenqin Fang, Xu Zhao, Yi Lou, Guanghui Wang, Huawei Zheng, Qifu Liang, Yakubu Saddeeq Abubakar, Stefan Olsson, Jie Zhou, Zonghua Wang
Endosomal sorting machineries regulate the transport of their cargoes among intracellular compartments. However, the molecular nature of such intracellular trafficking processes in pathogenic fungal development and pathogenicity remains unclear. Here, we dissect the roles and molecular mechanisms of two sorting nexin proteins and their cargoes in endosomal recycling in Fusarium graminearum using high-resolution microscopy and high-throughput co-immunoprecipitation strategies. We show that the sorting nexins, FgSnx41 and FgSnx4, interact with each other and assemble into a functionally interdependent heterodimer through their respective BAR domains...
April 20, 2018: New Phytologist
https://www.readbyqxmd.com/read/29668757/actin-polymerization-in-the-endosomal-pathway-but-not-on-the-coxiella-containing-vacuole-is-essential-for-pathogen-growth
#2
Heather E Miller, Charles L Larson, Robert A Heinzen
Coxiella burnetii is an intracellular bacterium that replicates within an expansive phagolysosome-like vacuole. Fusion between the Coxiella-containing vacuole (CCV) and late endosomes/multivesicular bodies requires Rab7, the HOPS tethering complex, and SNARE proteins, with actin also speculated to play a role. Here, we investigated the importance of actin in CCV fusion. Filamentous actin patches formed around the CCV membrane that were preferred sites of vesicular fusion. Accordingly, the mediators of endolysosomal fusion Rab7, VAMP7, and syntaxin 8 were concentrated in CCV actin patches...
April 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29667289/endosomal-receptor-trafficking-retromer-and-beyond
#3
REVIEW
Jing Wang, Alina Fedoseienko, Bayou Chen, Ezra Burstein, Da Jia, Daniel D Billadeau
The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations in order to maintain cellular homeostasis. Although retromer was originally described in yeast as a regulator of endosome-to-Golgi receptor recycling, mammalian retromer has emerged as a central player in endosome-to-plasma membrane recycling of a variety of receptors. Over the past decade, information regarding the mechanism by which retromer facilitates receptor trafficking has emerged, as has the identification of numerous retromer-associated molecules including the WASH complex, sorting nexins and TBC1d5...
April 18, 2018: Traffic
https://www.readbyqxmd.com/read/29665429/autophagy-in-mammalian-neurodevelopment-and-implications-for-childhood-neurological-disorders
#4
REVIEW
Derek Marsh, Joanna M Dragich
Here we explore the neurodevelopmental aspects of macroautophagy (henceforth known as autophagy), the process by which cells remove and remodel their structure in a regulated and spatially restricted manner. Autophagy is a catabolic pathway in which cytosolic substances, such as protein complexes, lipids, and organelles, are engulfed by an autophagic vesicle. Degradation occurs once an autophagosome fuses with a lysosome, allowing the macromolecular cargo sequestered within the autophagic vesicle to be recycled...
April 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29655915/real-time-monitoring-of-ph-dependent-intracellular-trafficking-of-ovarian-cancer-g-protein-coupled-receptor-1-in-living-leukocytes
#5
Modong Tan, Satoshi Yamaguchi, Motonao Nakamura, Teruyuki Nagamune
G-protein coupled receptors (GPCRs) are involved in many diseases and important biological phenomena; elucidating the mechanisms underlying regulation of their signal transduction potentially provides both novel targets for drug discovery and insight into living systems. A proton-sensing GPCR, ovarian cancer G protein-coupled receptor 1 (OGR1), has been reported to be related to acidosis and diseases that cause tissue acidification, but the mechanism of proton-induced activation of OGR1-mediated signal transduction in acidic conditions remains unclear...
April 11, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29651536/septin-localization-and-function-during-autophagy
#6
REVIEW
Gaurav Barve, Priyadarshini Sanyal, Ravi Manjithaya
Autophagy is a vital conserved recycling process where eukaryotic cells remove unwanted proteins and organelles via lysosomal degradation and in turn, generate nutrients for the cells. The special feature of autophagy process is the formation of double-membrane vesicles called autophagosomes that engulf cellular cargo and deliver them to the vacuole or lysosomes for degradation. Inspite of more than 40 AuTophaGy (ATG) proteins and several organelles as known membrane source, autophagosome biogenesis is not entirely understood...
April 12, 2018: Current Genetics
https://www.readbyqxmd.com/read/29649283/design-and-preclinical-characterization-of-alxn1210-a-novel-anti-c5-antibody-with-extended-duration-of-action
#7
Douglas Sheridan, Zhao-Xue Yu, Yuchun Zhang, Rekha Patel, Fang Sun, Melissa A Lasaro, Keith Bouchard, Bruce Andrien, Andre Marozsan, Yi Wang, Paul Tamburini
Eculizumab, a monoclonal antibody (mAb) directed against complement protein C5, is considered to be the current standard of care for patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome. This study describes the generation and preclinical attributes of ALXN1210, a new long-acting anti-C5 mAb, obtained through select modifications to eculizumab to both largely abolish target-mediated drug disposition (TMDD) and increase recycling efficiency via the neonatal Fc receptor (FcRn)...
2018: PloS One
https://www.readbyqxmd.com/read/29643171/fungal-morphogenesis-from-the-polarized-growth-of-hyphae-to-complex-reproduction-and-infection-structures
#8
REVIEW
Meritxell Riquelme, Jesús Aguirre, Salomon Bartnicki-García, Gerhard H Braus, Michael Feldbrügge, Ursula Fleig, Wilhelm Hansberg, Alfredo Herrera-Estrella, Jörg Kämper, Ulrich Kück, Rosa R Mouriño-Pérez, Norio Takeshita, Reinhard Fischer
Filamentous fungi constitute a large group of eukaryotic microorganisms that grow by forming simple tube-like hyphae that are capable of differentiating into more-complex morphological structures and distinct cell types. Hyphae form filamentous networks by extending at their tips while branching in subapical regions. Rapid tip elongation requires massive membrane insertion and extension of the rigid chitin-containing cell wall. This process is sustained by a continuous flow of secretory vesicles that depends on the coordinated action of the microtubule and actin cytoskeletons and the corresponding motors and associated proteins...
June 2018: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/29627764/dynamic-role-of-the-transmembrane-glycoprotein-cd36-sr-b2-in-cellular-fatty-acid-uptake-and-utilization
#9
Jan F C Glatz, Joost J F P Luiken
The widely expressed transmembrane glycoprotein CD36, a scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and signaling. Here, we review CD36's role in facilitating cellular long-chain fatty-acid uptake across the plasma membrane, particularly in heart and skeletal muscles. CD36 acts in concert with other membrane proteins, such as peripheral plasma membrane fatty acid-binding protein (FABPpm), and is an intracellular docking site for cytoplasmic FABP (FABPc). The cellular fatty-acid uptake rate is governed primarily by the presence of CD36 at the cell surface, which is regulated by the subcellular vesicular recycling of CD36 from endosomes to the plasma membrane...
April 7, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29615992/epstein-barr-virus-acquires-its-final-envelope-on-intracellular-compartments-with-golgi-markers
#10
Asuka Nanbo, Takeshi Noda, Yusuke Ohba
Herpesvirus subfamilies typically acquire their final envelope in various cytoplasmic compartments such as the trans -Golgi network (TGN), and endosomes prior to their secretion into the extracellular space. However, the sites for the final envelopment of Epstein-Barr virus (EBV), a ubiquitous human gamma herpesvirus, are poorly understood. Here, we characterized the sites for the final envelopment of EBV in Burkitt's lymphoma cell lines induced into the lytic cycle by crosslinking cell surface IgG. Electron microscopy revealed the various stages of maturation and egress of progeny virions including mature EBV in irregular cytoplasmic vesicles...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29608571/endocytic-recycling-via-the-tgn-underlies-the-polarized-hyphal-mode-of-life
#11
Miguel Hernández-González, Ignacio Bravo-Plaza, Mario Pinar, Vivian de Los Ríos, Herbert N Arst, Miguel A Peñalva
Intracellular traffic in Aspergillus nidulans hyphae must cope with the challenges that the high rates of apical extension (1μm/min) and the long intracellular distances (>100 μm) impose. Understanding the ways in which the hyphal tip cell coordinates traffic to meet these challenges is of basic importance, but is also of considerable applied interest, as fungal invasiveness of animals and plants depends critically upon maintaining these high rates of growth. Rapid apical extension requires localization of cell-wall-modifying enzymes to hyphal tips...
April 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29582527/rab11-mediates-selective-recycling-and-endocytic-trafficking-in-trypanosoma-brucei
#12
Khan Umaer, Peter J Bush, James D Bangs
Trypanosoma brucei possesses a streamlined secretory system that guarantees efficient delivery to the cell surface of the critical GPI-anchored virulence factors, variable surface glycoprotein (VSG) and transferrin receptor (TfR). Both are thought to be constitutively endocytosed and returned to the flagellar pocket via TbRab11+ recycling endosomes. We use conditional knockdown with established reporters to investigate the role of TbRab11 in specific endomembrane trafficking pathways in bloodstream trypanosomes...
March 26, 2018: Traffic
https://www.readbyqxmd.com/read/29573490/extracellular-matrix-internalization-links-nutrient-signalling-to-invasive-migration
#13
REVIEW
Elena Rainero
Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others have shown that integrin can be endocytosed together with their ECM ligands. In this short review, I will highlight how extracellular protein (including ECM) endocytosis impinges on the activation of the mechanistic target of rapamycin (mTOR) pathway, a master regulator of cell metabolism and growth...
March 24, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29567836/histone-deacetylase-mediated-regulation-of-endolysosomal-ph
#14
Hari Prasad, Rajini Rao
The pH of the endolysosomal system is tightly regulated by a balance of proton pump and leak mechanisms that are critical for storage, recycling, turnover, and signaling functions in the cell. Dysregulation of endolysosomal pH has been linked to aging, amyloidogenesis, synaptic dysfunction, and various neurodegenerative disorders, including Alzheimer's disease. Therefore, understanding the mechanisms that regulate luminal pH may be key to identifying new targets for managing these disorders. Metaanalysis of yeast microarray databases revealed that nutrient limiting conditions inhibited the histone deacetylase (HDAC) Rpd3 and thereby upregulated transcription of the endosomal Na+ /H+ exchanger Nhx1, resulting in vacuolar alkalinization...
March 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29567645/ptrn-1-camsap-promotes-cyk-1-formin-dependent-actin-polymerization-during-endocytic-recycling
#15
Ting Gong, Yanling Yan, Jing Zhang, Shuai Liu, Hang Liu, Jinghu Gao, Xin Zhou, Juan Chen, Anbing Shi
Cargo sorting and membrane carrier initiation in recycling endosomes require appropriately coordinated actin dynamics. However, the mechanism underlying the regulation of actin organization during recycling transport remains elusive. Here we report that the loss of PTRN-1/CAMSAP stalled actin exchange and diminished the cytosolic actin structures. Furthermore, we found that PTRN-1 is required for the recycling of clathrin-independent cargo hTAC-GFP The N-terminal calponin homology (CH) domain and central coiled-coils (CC) region of PTRN-1 can synergistically sustain the flow of hTAC-GFP We identified CYK-1/formin as a binding partner of PTRN-1...
March 22, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29563216/sac-1-ensures-epithelial-endocytic-recycling-by-restricting-arf-6-activity
#16
Dan Chen, Chao Yang, Sha Liu, Weijian Hang, Xianghong Wang, Juan Chen, Anbing Shi
Arf6/ARF-6 is a crucial regulator of the endosomal phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) pool in endocytic recycling. To further characterize ARF-6 regulation, we performed an ARF-6 interactor screen in Caenorhabditis elegans and identified SAC-1, the homologue of the phosphoinositide phosphatase Sac1p in yeast, as a novel ARF-6 partner. In the absence of ARF-6, basolateral endosomes show a loss of SAC-1 staining in epithelial cells. Steady-state cargo distribution assays revealed that loss of SAC-1 specifically affected apical secretory delivery and basolateral recycling...
March 21, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29560581/the-endo-lysosomal-system-of-brain-endothelial-cells-is-influenced-by-astrocytes-in-vitro
#17
Andrea E Toth, Piotr Siupka, Thomas J P Augustine, Susanne T Venø, Louiza B Thomsen, Torben Moos, Hannes T Lohi, Peder Madsen, Karin Lykke-Hartmann, Morten S Nielsen
Receptor- and adsorptive-mediated transport through brain endothelial cells (BEC) of the blood-brain barrier (BBB) involves a complex array of subcellular vesicular structures, the endo-lysosomal system. It consists of several types of vesicles, such as early, recycling, and late endosomes, retromer-positive structures, and lysosomes. Since this system is important for receptor-mediated transcytosis of drugs across brain capillaries, our aim was to characterise the endo-lysosomal system in BEC with emphasis on their interactions with astrocytes...
March 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29549340/transcytosis-of-trka-leads-to-diversification-of-dendritic-signaling-endosomes
#18
Kelly Barford, Austin Keeler, Lloyd McMahon, Kathryn McDaniel, Chan Choo Yap, Christopher D Deppmann, Bettina Winckler
The development of the peripheral nervous system relies on long-distance signaling from target organs back to the soma. In sympathetic neurons, this long-distance signaling is mediated by target derived Nerve Growth Factor (NGF) interacting with its axonal receptor, TrkA. This ligand receptor complex internalizes into what is commonly referred to as the signaling endosome which is transported retrogradely to the soma and dendrites to mediate survival signaling and synapse formation, respectively. The molecular identity of signaling endosomes in dendrites has not yet been determined...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29545368/commd-family-regulates-plasma-ldl-levels-and-attenuates-atherosclerosis-through-stabilizing-the-ccc-complex-in-endosomal-ldlr-trafficking
#19
Alina Fedoseienko, Melinde Wijers, Justina C Wolters, Daphne Dekker, Marieke Smit, Nicolette Huijkman, Niels Kloosterhuis, Helene Klug, Aloys Schepers, Ko Willems van Dijk, Johannes H Levels, Daniel D Billadeau, Marten H Hofker, Jan van Deursen, Marit Westerterp, Ezra Burstein, Jan Albert Kuivenhoven, Bart van de Sluis
<u>Rationale:</u> <u>CO</u> pper<u>M</u>etabolism<u>M</u>URR1 Domain-containing (COMMD) proteins are a part of the COMMD-CCDC22-CCDC93 (CCC) complexes facilitating endosomal trafficking of cell surface receptors. Hepatic COMMD1 inactivation decreases CCDC22 and CCDC93 protein levels, impairs the recycling of the low-density lipoprotein receptor (LDLR), and increases plasma LDL cholesterol levels in mice. However, whether any of the other COMMD members function similarly as COMMD1, and whether perturbation in the CCC complex promotes atherogenesis remain unclear...
March 15, 2018: Circulation Research
https://www.readbyqxmd.com/read/29545069/ascorbic-acid-increases-svct2-localization-at-the-plasma-membrane-by-accelerating-its-trafficking-from-early-secretory-compartments-and-through-the-endocytic-recycling-pathway
#20
A Covarrubias-Pinto, A I Acuña, G Boncompain, E Pápic, P V Burgos, F Perez, M A Castro
Ascorbic acid (Asc) is an antioxidant molecule essential for physiological functions. The concentration of extracellular Asc increases during synaptic transmission and renal reabsorption. These phenomena induce an increase of the Sodium-dependent-Vitamin-C-transporter 2 (SVCT2) at plasma membrane (PM) localization, as we previously demonstrated in neuronal and non-neuronal cells. Hence, the aim of this study was to evaluate intracellular SVCT2 trafficking kinetics in response to Asc. We observed two peaks of SVCT2 localization and function at the PM (at 5-10min, "acute response", and 30-60min, "post-acute response") when cells were incubated with Asc...
March 12, 2018: Free Radical Biology & Medicine
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